MDP0000209776, MDP0000209776 (mRNA) Malus spp. (apple)

Query:  280 ATSSLNSGASEKLPSIPAAAP-----EDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGA-RKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSK-SPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVS-ENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVNGNVGPWFNHS 5283
            ++S++ S + +  P I   +P     +D S+A+  SRDG G QESVTVDRR ++S VC+WTV NFP+IKARALWSKYFEVGG+DCRLLIYPKGDSQALPGYIS+YLQIMDPRG+SSSKWDCFASYRLAIVN ADDSK+IHRDSWHRFSSKKKSHGWCDFTPS+T+FDSK GYLFN DSVLITADILILNESVNFTRD    NNELQ           VAGPVSDVLSGKFTWKV NFSLFKEMIKTQKIMSP               SSVNGVEYLSMCLESKDT+K VV SDRSCWCLFRMSVLNQKP  NHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDF+G++SGFL+DDTAVFSTSFHVIKEFSSFSKNGGLI  R GSG  RK DGH+GKF WRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTD+RNTSSDWSCFVSHRLSVVNQRME+KSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETS M + TDQD+ESSN+GSQIDK GKRSSFTW+VENF+SFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVG D DKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEV ASEDDQDALTTDPDEL+               FRNLLSRAGFHLTYGDNP+QPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGS+DG KV K DESSPSLMNLLMGVKVLQQA        MVECCQP+EG S  D SD NSK SP GSGA  PL+ DRENGATES++ P  ERL                  + G  VP K +PG+PI PPETSAG S EN +LRSKTKWPEQSEELLGLIVNSLRALDGAV            SAQKIALVLDKAPKHLQ DLVALVPKLVEHSEHPLAA AL++RLQKPDAEPALR PVFGALSQL+CGSEVWER+L QSFE L DSNDEPL ATI+FIFKAASQCQHLPEAVRS+RV+LK+LG ++SPCVL+FL++TVNSWGDVAETILRDIDCDD+FGD CST+  GLFLFGE+GP SER H +DEQAF ++R FSDIY+LIEMLSIPCLAVEASQTFERAVARGA VA SVAMVLE RLAQRLN +++F+ ++FQ TDV  EG+ NEQLR QRDDF+SVLGLAETLALSRDP VKGFVK+LYT+LFKWYADE+YRGRMLKRLVD ATSTTDS+ E+DL+L+ILV L  EEQEI+RPVLSMMREVAELANVDRAALWHQLC SEDEIIRMREE+KAE + +VKEKA+I Q+LSESEAT+ RLKSEM+AE D FAREKKELSEQIQEVESQLEW RSERD+EI +L +E+KVLQDRLHDAE QLSQLKSRKRDELK++VKEKNALAERLK+AE ARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVAR EAYI  MESKLQAC            QQ IHTL ASL+EEMSRHAPLYGAGLEALSMKELETL+ IHEEGLRQIH +  QQ KGSP+ SPLVSPH LQH+HGLYP  PP MAVG+PPSLIPNGVGIHSNGHVNG VG WFNH+
Sbjct:   18 SSSTVPSSSEQSQPPIATPSPSPSMGDDPSLAA--SRDGHG-QESVTVDRRTDFSAVCKWTVHNFPKIKARALWSKYFEVGGFDCRLLIYPKGDSQALPGYISVYLQIMDPRGSSSSKWDCFASYRLAIVNHADDSKSIHRDSWHRFSSKKKSHGWCDFTPSTTLFDSKSGYLFNNDSVLITADILILNESVNFTRD----NNELQSASSMASMV--VAGPVSDVLSGKFTWKVHNFSLFKEMIKTQKIMSPVFPAGECNLRISVYQSSVNGVEYLSMCLESKDTEKAVV-SDRSCWCLFRMSVLNQKPGLNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFIGSDSGFLVDDTAVFSTSFHVIKEFSSFSKNGGLIGVRGGSGGTRKSDGHLGKFTWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDSRNTSSDWSCFVSHRLSVVNQRMEDKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSTMLDLTDQDSESSNSGSQIDKIGKRSSFTWRVENFMSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGSDPDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVLASEDDQDALTTDPDELIDSEDSEGISGDEEDIFRNLLSRAGFHLTYGDNPAQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSNDGKKVTKTDESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPSEGNSNDDSSDENSKLSPGGSGAVSPLESDRENGATESAEFPVYERLDSGVYESTNVSAVQSSD-MNGTVVPEKAVPGQPISPPETSAGGSIENASLRSKTKWPEQSEELLGLIVNSLRALDGAVPQGCPEPRRRPQSAQKIALVLDKAPKHLQPDLVALVPKLVEHSEHPLAACALLDRLQKPDAEPALRIPVFGALSQLECGSEVWERILFQSFELLSDSNDEPLAATINFIFKAASQCQHLPEAVRSIRVKLKHLGAEVSPCVLDFLNKTVNSWGDVAETILRDIDCDDDFGDNCSTIPCGLFLFGENGPTSERLHAIDEQAFCATRHFSDIYLLIEMLSIPCLAVEASQTFERAVARGAFVAQSVAMVLESRLAQRLNFNSRFVAESFQHTDVVVEGETNEQLRAQRDDFSSVLGLAETLALSRDPRVKGFVKVLYTILFKWYADESYRGRMLKRLVDRATSTTDSSREIDLELEILVILVCEEQEIVRPVLSMMREVAELANVDRAALWHQLCTSEDEIIRMREERKAEISNLVKEKAIISQRLSESEATSNRLKSEMRAEADRFAREKKELSEQIQEVESQLEWLRSERDEEITKLTSEKKVLQDRLHDAEAQLSQLKSRKRDELKRVVKEKNALAERLKSAEAARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARCEAYIDGMESKLQAC------------QQYIHTLEASLQEEMSRHAPLYGAGLEALSMKELETLARIHEEGLRQIHAI--QQHKGSPAGSPLVSPHTLQHSHGLYPPAPPPMAVGLPPSLIPNGVGIHSNGHVNGAVGSWFNHN 1683          

Query:  271 SQPATSSLNSGAS----EKLPSIPAAAPEDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSK-SPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVN--GNVGPWFNHS 5283
            S  A  SL+S  S        S  AAA EDL+V S     GGGAQE+V VDRRGEYS +CRWTV NFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPS+TVFD KLGYLFNTDSVLITADILILNESVNFTRD NN                 VAGPVSDV SGKFTWKV NFSLFKEMIKTQKIMSP               SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKP +NHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDF+G +SGFL+DDTAVFSTSFHVIKEFSSFSKNG +I GRS SGARK DGH+GKF WRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTD+RNTSSDWSCFVSHRLSVVNQRME+KSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTV+FSAEVLILKETS MQ+ T+ D+E S++GSQ+D NGKRSSF+WKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQ+VG D DKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLE+DAGFLVRDTVVFVCEILDCCPWFEFSDLEV ASEDDQDALTTDPDEL+               FRNLL RAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGS DG K  K DESSPSLMNLLMGVKVLQQA        MVECCQP+E     D  DA SK SP+GSGAA P + +RENGA ES+  P CERL                  + G G+  K LPG+PICPPETSA  SEN +LRSKTKWPEQSEELLGLIVNSLRALDGAV            SAQKI+LVLDKAPKHLQ+DLVALVPKLVE SEHPLAA+AL+ERLQKPDAEPALR PV+GALSQL+CGSEVWER+L QSFE L DSNDEPL ATIDFIFKAASQCQHLPEAVRSVRVRLKNLG+++SPCVL+FLS+T+NSWGDVAETILRDIDCDD++GD+CS L  G+FLFGEH       H +DEQA+ +SR FSDIYIL EMLSIPCL  EASQTFERAVARG I A SVA+VL+ RL+QRLN +  ++ +N Q +D A EGDA EQL +QRDD+TSVLGLAE LALSRDPCVK FVK+LY ++F+W+A+E+YRGRMLKRLVD ATS TD+  EVD DLDILVTL  EEQE IRPVLSMMREVAELANVDRAALWHQLCASEDEI+R+REE K E + M KEK++I QKL+ESEAT+ RLKSEM+AE+D F+REKKEL+EQIQEVESQLEW RSERDDEI +L+ E+K L DRLHDAETQLSQLKSRKRDELKK+VKEKNALAERLKNAE ARKRFDEELKR+ATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVAR EAYI  MESKLQAC            QQ IHTL ASL+EEMSRHAPLYGAGLEALS+KELETLS IHE+GLRQIH L  QQRKGSP+ SPLVSPHAL H+HGLYP+  P MAVG+PPS+IPNGVGIHSNGHVN  G VGPWFNHS
Sbjct:    5 SSEAVPSLSSAPSFTETATSSSWSAAAAEDLTVGSRDG--GGGAQETVAVDRRGEYSALCRWTVHNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSNTVFDPKLGYLFNTDSVLITADILILNESVNFTRD-NNEVQSSSSSSSNAMTSSVVAGPVSDVSSGKFTWKVHNFSLFKEMIKTQKIMSPVFPAGECNLRISVYQSSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPGSNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFIGADSGFLVDDTAVFSTSFHVIKEFSSFSKNGAVIAGRSASGARKSDGHIGKFTWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDSRNTSSDWSCFVSHRLSVVNQRMEDKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVIFSAEVLILKETSTMQDITENDSELSSSGSQVDGNGKRSSFSWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQAVGSDPDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLESDAGFLVRDTVVFVCEILDCCPWFEFSDLEVLASEDDQDALTTDPDELIDSEDSEGISGDEEDIFRNLLFRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSCDGKKASKADESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPSEVGPVADSVDACSKPSPNGSGAASPFECERENGAMESARVPVCERL-DSVVQESSNASAVQSSDLKGNGLQEKALPGQPICPPETSATASENASLRSKTKWPEQSEELLGLIVNSLRALDGAVPQGCPEPRRRPQSAQKISLVLDKAPKHLQADLVALVPKLVEQSEHPLAAYALLERLQKPDAEPALRIPVYGALSQLECGSEVWERILFQSFELLTDSNDEPLTATIDFIFKAASQCQHLPEAVRSVRVRLKNLGLEVSPCVLDFLSKTINSWGDVAETILRDIDCDDDYGDSCSALPCGIFLFGEHDTAPSGLHVIDEQAYHASRHFSDIYILFEMLSIPCLVAEASQTFERAVARGVISAQSVALVLQSRLSQRLNNNGSYVSENCQHSDDATEGDACEQLGVQRDDYTSVLGLAENLALSRDPCVKEFVKLLYMIMFRWFANESYRGRMLKRLVDCATSNTDNGREVDFDLDILVTLVCEEQEFIRPVLSMMREVAELANVDRAALWHQLCASEDEIMRVREESKTEISNMAKEKSMISQKLTESEATSNRLKSEMRAEMDRFSREKKELAEQIQEVESQLEWIRSERDDEIAKLSAEKKALHDRLHDAETQLSQLKSRKRDELKKVVKEKNALAERLKNAEAARKRFDEELKRFATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARCEAYIDGMESKLQAC------------QQYIHTLEASLQEEMSRHAPLYGAGLEALSLKELETLSRIHEDGLRQIHAL--QQRKGSPAGSPLVSPHALPHSHGLYPTASPPMAVGLPPSIIPNGVGIHSNGHVNGGGGVGPWFNHS 1679          

Query:  265 DHSQPATSSLNSGASEKLPSIPAAAPEDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNEL--QXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIG-------------------------------------VYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTE-GTSYGDLSDANSKSPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVNGNVGPWFNH 5280
            D SQPATSS +S +        AAA EDL++ S   RDGG A E+V VDRR EYS VC+WTV NFP++KARALWSKYFEVGGYDCRLLIYPKGDSQALPGYIS+YL+IMDPRGTSSSKWDCFASYRLA VN+ DDSKTIHRDSWHRFS+KK+SHGWCDFTP+ST+FD KLGYLFN DSVLITADILILNESVNFTR+    NNEL              VAGPVSDVLSGKFTWKV NFSLFKEMI+TQKIMSP               S+V+GVEYLSMCLESKDTDK  +LSDRSCWCLFRMSVLNQKP +NHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGT+SGF++DDTAVFSTSFHVIKEFSSFSKNG +I GRSG  ARK DGH+GKF WRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTD+RN+SSDWSCFVSHRLSVVNQ+ E+KSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTV+FSAEVLILKETSIMQ+FT+ D+ES+++ S +D  GKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIG                                     VYESFDTICIYLESDQ+VG D DKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFL+RDTVVFVCEILDCCPWF+FSDLEVFASEDDQDALTTDPDEL+               FRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGS DG K  K DESSPSLMN+LMGVKVLQQA        MVECCQP+E G     + + +  SPD SG A PL  D EN A ES+     ERL                  + G  +  K LPG+PICPPET A VSEN + RSKTKWP+QSEELLGLIVNSLRALDGAV            SAQKIALVLDKAPKHLQ+DLV LVPKLVE SEHPLAA+ALIERLQ+PDAEPALR PVFGALSQL+CGSEVWER+L QSFE L DSNDEPLVATIDFIFKAASQCQHLPEAVR+VRVRLK+LG+D+SPCVL+FLS+T+NSWGDVAETILRDIDCD+++G++C+ L  G+FLFGEHG  +   H +DEQAFR+SR FSDIYIL+EMLSIPCLAVEASQTFERAVARGAI A SVA+VLE   +QRLN +A+   +NFQ  D A E DA EQ  +QRDDFTSVLGLAETLALSRD CVK FVK+LY ++F+WYA+E+YRGRMLKRLVD ATSTTD+  EVD DLDILVTL  EEQE IRPVLSMMR VAELANVDRAALWHQLCASEDEII +REE K + + M  EKAV+ QKLSESEATN RLKSEMKAE+D F+REKKEL+E IQE+ESQLEWHRSERDDEI +L++E+KVL DRLHDAE QLSQLKSRKRDELKK+VKEKNALAERLKNAE ARKRFDEELKR+ATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVAR EAYI  MESKLQAC            QQ IHTL ASL+EEMSRHAPLYGAGLEALSMKELET+S IHEEGLRQIH L  QQRKGSP+ SPL+SPHAL H+HGLYP+     +VG+PPS+IPNGVGIHSNGHVNG VGPWFNH
Sbjct:   23 DQSQPATSSSSSSS--------AAAAEDLAIGS---RDGGSALETVVVDRRNEYSAVCKWTVNNFPKVKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISVYLKIMDPRGTSSSKWDCFASYRLAFVNVVDDSKTIHRDSWHRFSTKKQSHGWCDFTPASTIFDPKLGYLFNNDSVLITADILILNESVNFTRE----NNELLSSSLSSSTLSSSVVAGPVSDVLSGKFTWKVHNFSLFKEMIRTQKIMSPIFPAGECNLRISVYQSTVSGVEYLSMCLESKDTDKNAMLSDRSCWCLFRMSVLNQKPGSNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTDSGFVVDDTAVFSTSFHVIKEFSSFSKNGAVIGGRSGGSARKSDGHIGKFTWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDSRNSSSDWSCFVSHRLSVVNQKTEDKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVIFSAEVLILKETSIMQDFTEHDSESNSSSSLLDSTGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGMCFMAHILSPAFYPLAVVIANLNYYSLIKSLCFNPPGVYESFDTICIYLESDQAVGSDPDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLLRDTVVFVCEILDCCPWFDFSDLEVFASEDDQDALTTDPDELIDSEGSEGISGDEEDIFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSCDGKKATKADESSPSLMNMLMGVKVLQQAIIDLLLDIMVECCQPSEVGPVSDSVEECSKPSPDSSGTASPLHCDNENRAVESAQVLVHERLDSVVEESCSTSSVQSSD-LNGHCIQEKALPGQPICPPETCATVSENTSFRSKTKWPDQSEELLGLIVNSLRALDGAVPQGCPEPRRRPQSAQKIALVLDKAPKHLQADLVTLVPKLVEQSEHPLAAYALIERLQQPDAEPALRIPVFGALSQLECGSEVWERILFQSFELLTDSNDEPLVATIDFIFKAASQCQHLPEAVRTVRVRLKSLGLDVSPCVLDFLSKTINSWGDVAETILRDIDCDEDYGESCTALPCGIFLFGEHGAAATGLHMIDEQAFRASRHFSDIYILLEMLSIPCLAVEASQTFERAVARGAIGAQSVALVLESLFSQRLNNNART--ENFQHPDGATEEDACEQFGVQRDDFTSVLGLAETLALSRDLCVKEFVKLLYMIIFRWYANESYRGRMLKRLVDRATSTTDNGREVDFDLDILVTLVCEEQEYIRPVLSMMRGVAELANVDRAALWHQLCASEDEIIHIREENKTDISNMASEKAVLSQKLSESEATNNRLKSEMKAEVDQFSREKKELAEHIQEIESQLEWHRSERDDEILKLSSEKKVLHDRLHDAEAQLSQLKSRKRDELKKVVKEKNALAERLKNAEAARKRFDEELKRFATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARCEAYIDGMESKLQAC------------QQYIHTLEASLQEEMSRHAPLYGAGLEALSMKELETISRIHEEGLRQIHAL--QQRKGSPAGSPLLSPHALPHSHGLYPAG----SVGLPPSVIPNGVGIHSNGHVNGAVGPWFNH 1713          

Query:  265 DHSQPATSSLNSGASEKLPSIPAAAPEDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRD--SNNNNNELQXXXXXXXXXXXVA-GPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPX-TNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSK-SPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAG-VSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVNGNVG 5265
            D S  ATSS  + A+   P+      +D++V +T     G A E+VT+DRRGEYS +C+WTVQNFPR+KARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRL+I N  DDSKTIHRDSWHRFSSKKKSHGWCDFTP+STVFDSKLGYLFN D VLITADILILNESV+F RD  S+ +NNE+Q           V  GPVSDVLSGKFTWKV NFSLFKEMIKTQKIMS                SSVNG +YLSMCLESKDT+KT V SDRSCWCLFRMSVLNQK   +NH+HRDSYGRFAADNKSGDNTSLGWNDYMKM+DFVG ESGFL+DDTAVFSTSFHVIKEFSSFSKNGGL  GR G GARK DGHMGKF WRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPR          VFLEVTD+RNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQ+F DQDTES+N+ SQID  GKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVG D DKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLE DAGFLVRDTVVFVCEILDCCPWFEFSDLEV ASEDDQDALTTDPDEL+               FRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGS+D  K  K DESSPSLMNLLMGVKVLQQA        MVECCQP+EG+S  D SDA+ K S DGSGAA PL+ DRE+GATES+  P  ERL                  + G G+P + LPG+PI PP T+AG  S N +LRSKTKWPEQSEELLGLIVNSLRALDGAV            SAQKIALVLDKAPKHLQ DLV+LVPKLVEH+EHPL A+AL+ERLQKPDAEPALR PVFGALSQL+CGS+VWERVL QSF+ L DSNDEPL ATIDFIFKAASQCQHLPEAVRSVR RLK LG D+SP VL+FLS+TVNSWGDVAETILRDIDCDD+ GD+CSTL  GLFLFGE+   +ER   VDEQ F SS  FSDIYILIEMLSIPCLA+EASQTFERAV RGAI+A SVA+VLERRLAQRLN +A+F+ +NFQQ D   EG+A+EQLR+QRDDF+ VLGLAETLALSRD CVKGFVKMLY +LFKWYA+E  RGRMLKRLVD ATSTTD++ +VDLDLDIL  L  EEQEI++PVLSMMREVAELANVDRAALWHQLCASEDEIIRMR+E+KAE + M +EKA + QKLS+SEATN RLKSEM+AE+D FAREKKELSEQI EVESQLEW RSERDDEI +L  E+KVLQDRLHDAETQLSQLKSRKRDELK++VKEKNAL ERLK+AE ARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVAR EAYI  MESKLQAC            QQ IHTL ASL+EEM+RHAPLYGAGLEALSM+ELET+S IHEEGLRQIH L  QQRKGSP +SP VSPH L HNHG+YP+ PP MAVG+PP LI NGVGIHSNGH+NG VG
Sbjct:   21 DQSSLATSSSTTTAT---PTSTTTTIDDITVGTTRDGTNGAAAEAVTIDRRGEYSAICKWTVQNFPRVKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLSIFNPLDDSKTIHRDSWHRFSSKKKSHGWCDFTPASTVFDSKLGYLFNNDCVLITADILILNESVSFIRDNSSSTSNNEVQSGVSLSISSNSVVVGPVSDVLSGKFTWKVHNFSLFKEMIKTQKIMSQVFPAGECNLRISVYQSSVNGTDYLSMCLESKDTEKTSV-SDRSCWCLFRMSVLNQKAGGSNHVHRDSYGRFAADNKSGDNTSLGWNDYMKMADFVGAESGFLVDDTAVFSTSFHVIKEFSSFSKNGGLNGGRIGGGARKSDGHMGKFTWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPR----------VFLEVTDSRNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQDFIDQDTESTNSASQIDGVGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGSDPDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLETDAGFLVRDTVVFVCEILDCCPWFEFSDLEVLASEDDQDALTTDPDELIDSDDSEGISGDEEDIFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSNDAKKATKADESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPSEGSSNDDSSDAHPKPSLDGSGAASPLESDRESGATESARFPVHERLDSGLDDSTRASAVQSSD-INGTGIPGQALPGQPIHPPVTTAGGASGNASLRSKTKWPEQSEELLGLIVNSLRALDGAVPQGCPEPRRRPQSAQKIALVLDKAPKHLQPDLVSLVPKLVEHAEHPLVAYALLERLQKPDAEPALRIPVFGALSQLECGSDVWERVLFQSFDLLADSNDEPLAATIDFIFKAASQCQHLPEAVRSVRSRLKILGADVSPFVLDFLSKTVNSWGDVAETILRDIDCDDDLGDSCSTLPCGLFLFGENASAAERLQVVDEQTFHSSSHFSDIYILIEMLSIPCLALEASQTFERAVGRGAIMAQSVAIVLERRLAQRLNFNARFVAENFQQEDAILEGEASEQLRVQRDDFSVVLGLAETLALSRDLCVKGFVKMLYMILFKWYANEPCRGRMLKRLVDHATSTTDNSRDVDLDLDILAILVCEEQEIVKPVLSMMREVAELANVDRAALWHQLCASEDEIIRMRDERKAEISNMAREKANLSQKLSDSEATNNRLKSEMRAEMDRFAREKKELSEQIHEVESQLEWVRSERDDEIIKLTVEKKVLQDRLHDAETQLSQLKSRKRDELKRVVKEKNALTERLKSAEAARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARCEAYIDGMESKLQAC------------QQYIHTLEASLQEEMTRHAPLYGAGLEALSMQELETISRIHEEGLRQIHVL--QQRKGSP-ASPHVSPHTLPHNHGMYPAAPPPMAVGLPP-LISNGVGIHSNGHINGAVG 1677          

Query:  343 EDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRD---SNNNNNELQXXXXXXXXXXXVA-GPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPX-TNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSK-SPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVS-ENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELK----------------------KLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVNGNVGPWFNHS 5283
            +D++V +T     G A E+VT+DRRGEYS  C+WTVQ+FPR+KARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRL+IVN  DDSKTIHRDSWHRFSSKKKSHGWCDFTP+STVFDSKLGYLFN D VLITADILILNESV+F RD   S+ +NNE+Q           VA GPVSDVLSGK TWKV NFSLFKEMIKTQKIMSP               SSVNG +YLSMCLESKDT+KTVV SDRSCWCLFRMSVLNQK   +NH+HRDSYGRFAADNKSGDNTSLGWNDYMKM+DF+G ESGFL+DDTAVFSTSFHVIKEFSSFSKNGGLI GR GSGARK DGHMGKF WRIENF RLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPR          VFLEVTD RNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQ+FTDQDTES+N  SQIDK GKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVG D DKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLE DAGFLV                         ASEDDQDALTTDPDEL+               FRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLD+PAKVK+LLLPTKLSG +DG K  K DESSPSLMNLLMGVKVLQQA        MVECCQP EG+S  D SDA+SK S DGSGAA PL+ DR +GATES+  P  ERL                  + G  +P + LPG+PI PP T+AG + EN +LRSKTKWPEQSEELLGLIVNSLRALDGAV            SAQKIALVLDKAPKHLQ DLV+L+PKLVEH+EHPLAA+AL+ERL+KPDAEPAL  PVFGALSQL+CGS+VWERVL QSF+ L DSNDEPL ATIDFIFKAASQCQHLPEAVRSVR RLKNLG D+SP VL+FLSRTVNSWGDVAETILRDIDCDD  GD+CSTL  GLFLFGE+   +ER H VDEQ F     FSDIYILIEMLSIPCLAVEASQTFERAVARGAI+A SVAMVLERRLAQRLN +A+F+ +NFQ TD   E +A+EQLR+QRDDF+ VLGLAETLALSRD CVKGFVKMLYT+LFKWYA+ETYRGRMLKRLVD ATSTTD++ +VDLDLDIL  L  EEQEI++PVLSMMREVAELANVDRAALWHQLCASEDEIIR+R+E+KAEN+ M +EKA + QKLS+ EATN RLKSEMKAE+D F REKKELSEQIQEVESQLEW RSERDDEI +L  E+KVLQDRLHDAETQLSQLKSRKRDELK                      K+VKEKNALAERLK+AE ARKRFDEELKRYATENVTREEIRQSLEDEVRRLT+TVGQTEGEKREKEEQVAR EAYI  MESKLQAC            QQ IHTL AS+++EM+RHAPLYGAGLEALSM+ELET+S IHEEGLRQIH L  QQ KGSP+SSP VSPH L HNHGLYP+ PP MAVG+PP LIPNGVGIH+NG VNG VGPWFNH+
Sbjct:   10 DDITVGTTLDGTNGAAAETVTIDRRGEYSATCKWTVQSFPRVKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLSIVNPLDDSKTIHRDSWHRFSSKKKSHGWCDFTPASTVFDSKLGYLFNNDCVLITADILILNESVSFMRDNSSSSTSNNEVQSGVSLSISSNSVAVGPVSDVLSGKCTWKVHNFSLFKEMIKTQKIMSPVFPAGECNLRISVYQSSVNGTDYLSMCLESKDTEKTVV-SDRSCWCLFRMSVLNQKAGGSNHVHRDSYGRFAADNKSGDNTSLGWNDYMKMADFIGAESGFLVDDTAVFSTSFHVIKEFSSFSKNGGLIGGRIGSGARKSDGHMGKFTWRIENFMRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPR----------VFLEVTDLRNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQDFTDQDTESTNGTSQIDKVGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGSDPDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLETDAGFLV------------------------LASEDDQDALTTDPDELIDSEDSEGNSGDEEDIFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDEPAKVKKLLLPTKLSGGNDGKKAAKADESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPLEGSSNDDSSDAHSKPSLDGSGAASPLESDRGSGATESAQFPVHERLDSGLDDSKRASAVQSSD-INGTDMPGQALPGQPIYPPVTTAGGALENASLRSKTKWPEQSEELLGLIVNSLRALDGAVPQGCPEPRRRPQSAQKIALVLDKAPKHLQPDLVSLIPKLVEHAEHPLAAYALLERLKKPDAEPALWIPVFGALSQLECGSDVWERVLIQSFDLLADSNDEPLAATIDFIFKAASQCQHLPEAVRSVRTRLKNLGADVSPFVLDFLSRTVNSWGDVAETILRDIDCDDALGDSCSTLPCGLFLFGENASAAERLHVVDEQTFHFRCHFSDIYILIEMLSIPCLAVEASQTFERAVARGAIMAQSVAMVLERRLAQRLNFNARFVNENFQHTDAIIEEEASEQLRVQRDDFSVVLGLAETLALSRDLCVKGFVKMLYTILFKWYANETYRGRMLKRLVDRATSTTDNSCDVDLDLDILAILVCEEQEIVKPVLSMMREVAELANVDRAALWHQLCASEDEIIRIRDERKAENSNMAREKANLSQKLSDCEATNNRLKSEMKAEMDRFTREKKELSEQIQEVESQLEWLRSERDDEITKLTVEKKVLQDRLHDAETQLSQLKSRKRDELKMQLFYCATSDHVAFLWRNVLEIKVVKEKNALAERLKSAEAARKRFDEELKRYATENVTREEIRQSLEDEVRRLTKTVGQTEGEKREKEEQVARCEAYIDGMESKLQAC------------QQYIHTLEASVQDEMTRHAPLYGAGLEALSMQELETISRIHEEGLRQIHAL--QQCKGSPASSPHVSPHTLPHNHGLYPAAPPPMAVGLPP-LIPNGVGIHNNGLVNGTVGPWFNHT 1649          

Query:  265 DHSQPATSSLNSGASEKLPSIPAAAPEDLSVASTPSRDG-GGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSKSPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQ---MAVGMPPSLIPNGVGIHSNGHVNGNVGPWFNH 5280
            D S P+ SS  S + + L S   +  EDL V S  SRDG GGAQE V VDR GEYS +CRWTV++F R+KA+ALWSKYF+VGGYDCRLL+YP+GDSQALPGYISIYLQIMDPRGT+SS+WDCFASYRL+IVNL DDS TIH+DSWHRFSSKKKSHGWCDFT +S++ D K+G+LFN DS+LITADILILNESV+F+RD+NN    L            +AGP+ DVLSGKFTWKV NFSLFK+MIKTQKIMSP               S VN  EY+SMCLESK+T+KT+V SDRSCWCLFRMS LNQKP   HMHRDSYGRFAADNKSGDNTSLGWNDYMKMS+FV  E+GFLLDD AVFSTSFHVIKEFSSF+KNGGLI GR+G+GARK DGHMGKF WRIENFTRLKDLLKKRKITGLCIKS+RFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTD+R+ SSDWSCFVSHRLSVVNQR+EEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETS  +E+ + D  S+N+ S  D + K+SSFTWKVENFL+FKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQS G D+D NFWV+Y+M ++NQKNPAK+VWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEV AS+DDQDALTTDPDE++               FR+ LSRAGFHLT+G+NPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDP KVKRLLLPTK+S  +D  K+IK+DESSPSLMNLLMGVKVLQQA        MVECCQP+E  S+ + S  + K+ DG  AA   +  RE GA E S     ER                   + GI +  K L  +P+ PP TSAG S + +++SKTKWPEQSEELLGLIVNSL+ LD AV            SAQKIALVLD+APKHLQ DLV+LVPKLVEHSEHPLAA ALIERLQKP+AEPALR PV+ ALSQL+C SEVWE +LSQSFE L D N+E LVA I F FK ASQCQHLPEAV +VR RLK+LG D+S CVL++LS+TV+SW  +AE ILRDI+ DD  G   +TL  G FL GE+   SE    ++E  F ++R F D+YIL+EMLSI CLA EASQTFERAVARGAIVA +VAMVLE++  Q  NL+A     + +  D   EG+A+EQ      +F  +L LAETL  SRDP V+GFVKMLYT+LFKW+ D+ +R ++L+RLVD  TS T S+H++DL+L+IL  L  +EQE+ RPVL+M+++V E AN+DRAALWHQL A+++E++R++EEKK E  +M KEK+ I QKLSESEA NTRLKSEMKAE D F+REKK+L EQ ++VESQLEW RSER DEI +L++E+K L DRLH+AETQL+  K+RKRDELKK+ KEKNAL E+LK  E ARKRF+EELKRYATENVTREE+R+SLED++R+LTQTVGQT+ EKREKE+Q+AR EAYI  MESKLQAC            QQ IHTL +SL+EE+SRHAPLYGA LE+LSMKEL+T++ IHEEGLRQIH L  QQRKG   S      H L   H LYP+TPPQ   MA+G+PP LIPNG G+HSNGH+NG+V PWF+H
Sbjct:   19 DQSHPSVSS--SSSEKPLSSSSISPAEDLQVGS--SRDGSGGAQEIVAVDRPGEYSALCRWTVESFTRVKAKALWSKYFDVGGYDCRLLVYPRGDSQALPGYISIYLQIMDPRGTTSSRWDCFASYRLSIVNLVDDSLTIHKDSWHRFSSKKKSHGWCDFTLNSSILDPKMGFLFNNDSLLITADILILNESVSFSRDNNNEGQSLYKENS-------IAGPMPDVLSGKFTWKVNNFSLFKDMIKTQKIMSPVFPAGECNLRISVYQSVVNSQEYISMCLESKETEKTLV-SDRSCWCLFRMSALNQKPGCTHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSEFVNPEAGFLLDDMAVFSTSFHVIKEFSSFTKNGGLIGGRNGAGARKSDGHMGKFTWRIENFTRLKDLLKKRKITGLCIKSKRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDSRS-SSDWSCFVSHRLSVVNQRLEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSATKEYVEAD--STNSVSPTDNSVKKSSFTWKVENFLAFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSAGTDVDNNFWVKYKMGILNQKNPAKSVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVLASDDDQDALTTDPDEIIDSEESEGISGDEEDTFRDFLSRAGFHLTFGENPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPTKVKRLLLPTKIS-CNDRSKLIKSDESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPSEEGSHSEPSLLSPKT-DGCVAATSSESTRERGAAEPSQHLVDERFKSDTDATLSTSAVPSSE-MNGIDLLEKALAIEPMSPPTTSAGQSSDASVQSKTKWPEQSEELLGLIVNSLKTLDAAVPQGCPEPRRRPHSAQKIALVLDRAPKHLQPDLVSLVPKLVEHSEHPLAALALIERLQKPEAEPALREPVYNALSQLECDSEVWEDILSQSFELLSDLNEESLVAAIHFTFKTASQCQHLPEAVNAVRERLKSLGADVSLCVLDYLSKTVHSWPGIAEMILRDINTDDSVGANFATLPCGPFLIGENETASEMADLMEEHIFYANRQFFDVYILLEMLSISCLAEEASQTFERAVARGAIVAQAVAMVLEKQRVQSPNLNATSGDASLKHQDPVLEGEASEQPATGGTEFRIILNLAETLTHSRDPQVRGFVKMLYTILFKWFPDQPFRVQILRRLVDRFTSPTSSSHDLDLELEILAILIFQEQEVARPVLAMLKKVVEHANIDRAALWHQLRANKEELVRLKEEKKIEIQSMTKEKSSITQKLSESEAANTRLKSEMKAEADRFSREKKDLVEQFRDVESQLEWIRSERQDEIDKLSSEKKTLLDRLHEAETQLALQKTRKRDELKKVGKEKNALTEKLKVTEAARKRFEEELKRYATENVTREELRKSLEDQIRQLTQTVGQTKEEKREKEDQIARCEAYIDGMESKLQAC------------QQYIHTLESSLREEISRHAPLYGANLESLSMKELDTIARIHEEGLRQIHAL--QQRKGHTLS------HGLPQGHTLYPTTPPQLPPMAIGLPPQLIPNGSGVHSNGHINGSVRPWFSH 1671          

Query:  265 DHSQPATSSLNSGASEKLPSIPAAAPEDLSVASTPSRDG-GGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSKSPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQ---MAVGMPPSLIPNGVGIHSNGHVNGN 5259
            D S P+ SS  S + + L S   +  EDL V S  SRDG GGAQE V VDR GEYS +CRWTV++F R+KA+ALWSKYF+VGGYDCRLL+YP+GDSQALPGYISIYLQIMDPRGT+SS+WDCFASYRL+IVNL DDS TIH+DSWHRFSSKKKSHGWCDFT +S++ D K+G+LFN DS+LITADILILNESV+F+RD+NN    L            +AGP+ DVLSGKFTWKV NFSLFK+MIKTQKIMSP               S VN  EY+SMCLESK+T+KT+V SDRSCWCLFRMS LNQKP   HMHRDSYGRFAADNKSGDNTSLGWNDYMKMS+FV  E+GFLLDD AVFSTSFHVIKEFSSF+KNGGLI GR+G+GARK DGHMGKF WRIENFTRLKDLLKKRKITGLCIKS+RFQIGNRDCRLIVYPR          VFLEVTD+R+ SSDWSCFVSHRLSVVNQR+EEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETS  +E+ + D  S+N+ S  D + K+SSFTWKVENFL+FKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQS G D+D NFWV+Y+M ++NQKNPAK+VWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEV AS+DDQDALTTDPDE++               FR+ LSRAGFHLT+G+NPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDP KVKRLLLPTK+S  +D  K+IK+DESSPSLMNLLMGVKVLQQA        MVECCQP+E  S+ + S  + K+ DG  AA   +  RE GA E S     ER                   + GI +  K L  +P+ PP TSAG S + +++SKTKWPEQSEELLGLIVNSL+ LD AV            SAQKIALVLD+APKHLQ DLV+LVPKLVEHSEHPLAA ALIERLQKP+AEPALR PV+ ALSQL+C SEVWE +LSQSFE L D N+E LVA I F FK ASQCQHLPEAV +VR RLK+LG D+S CVL++LS+TV+SW  +AE ILRDI+ DD  G   +TL  G FL GE+   SE    ++E  F ++R F D+YIL+EMLSI CLA EASQTFERAVARGAIVA +VAMVLE++  Q  NL+A     + +  D   EG+A+EQ      +F  +L LAETL  SRDP V+GFVKMLYT+LFKW+ D+ +R ++L+RLVD  TS T S+H++DL+L+IL  L  +EQE+ RPVL+M+++V E AN+DRAALWHQL A+++E++R++EEKK E  +M KEK+ I QKLSESEA NTRLKSEMKAE D F+REKK+L EQ ++VESQLEW RSER DEI +L++E+K L DRLH+AETQL+  K+RKRDELKK+ KEKNAL E+LK  E ARKRF+EELKRYATENVTREE+R+SLED++R+LTQTVGQT+ EKREKE+Q+AR EAYI  MESKLQAC            QQ IHTL +SL+EE+SRHAPLYGA LE+LSMKEL+T++ IHEEGLRQIH L  QQRKG   S      H L   H LYP+TPPQ   MA+G+PP LIPNG G+HSNGH+NG+
Sbjct:   19 DQSHPSVSS--SSSEKPLSSSSISPAEDLQVGS--SRDGSGGAQEIVAVDRPGEYSALCRWTVESFTRVKAKALWSKYFDVGGYDCRLLVYPRGDSQALPGYISIYLQIMDPRGTTSSRWDCFASYRLSIVNLVDDSLTIHKDSWHRFSSKKKSHGWCDFTLNSSILDPKMGFLFNNDSLLITADILILNESVSFSRDNNNEGQSLYKENS-------IAGPMPDVLSGKFTWKVNNFSLFKDMIKTQKIMSPVFPAGECNLRISVYQSVVNSQEYISMCLESKETEKTLV-SDRSCWCLFRMSALNQKPGCTHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSEFVNPEAGFLLDDMAVFSTSFHVIKEFSSFTKNGGLIGGRNGAGARKSDGHMGKFTWRIENFTRLKDLLKKRKITGLCIKSKRFQIGNRDCRLIVYPR----------VFLEVTDSRS-SSDWSCFVSHRLSVVNQRLEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSATKEYVEAD--STNSVSPTDNSVKKSSFTWKVENFLAFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSAGTDVDNNFWVKYKMGILNQKNPAKSVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVLASDDDQDALTTDPDEIIDSEESEGISGDEEDTFRDFLSRAGFHLTFGENPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPTKVKRLLLPTKIS-CNDRSKLIKSDESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPSEEGSHSEPSLLSPKT-DGCVAATSSESTRERGAAEPSQHLVDERFKSDTDATLSTSAVPSSE-MNGIDLLEKALAIEPMSPPTTSAGQSSDASVQSKTKWPEQSEELLGLIVNSLKTLDAAVPQGCPEPRRRPHSAQKIALVLDRAPKHLQPDLVSLVPKLVEHSEHPLAALALIERLQKPEAEPALREPVYNALSQLECDSEVWEDILSQSFELLSDLNEESLVAAIHFTFKTASQCQHLPEAVNAVRERLKSLGADVSLCVLDYLSKTVHSWPGIAEMILRDINTDDSVGANFATLPCGPFLIGENETASEMADLMEEHIFYANRQFFDVYILLEMLSISCLAEEASQTFERAVARGAIVAQAVAMVLEKQRVQSPNLNATSGDASLKHQDPVLEGEASEQPATGGTEFRIILNLAETLTHSRDPQVRGFVKMLYTILFKWFPDQPFRVQILRRLVDRFTSPTSSSHDLDLELEILAILIFQEQEVARPVLAMLKKVVEHANIDRAALWHQLRANKEELVRLKEEKKIEIQSMTKEKSSITQKLSESEAANTRLKSEMKAEADRFSREKKDLVEQFRDVESQLEWIRSERQDEIDKLSSEKKTLLDRLHEAETQLALQKTRKRDELKKVGKEKNALTEKLKVTEAARKRFEEELKRYATENVTREELRKSLEDQIRQLTQTVGQTKEEKREKEDQIARCEAYIDGMESKLQAC------------QQYIHTLESSLREEISRHAPLYGANLESLSMKELDTIARIHEEGLRQIHAL--QQRKGHTLS------HGLPQGHTLYPTTPPQLPPMAIGLPPQLIPNGSGVHSNGHINGS 1654          

Query:  280 ATSSLNSGASEKLPSIPAAAPEDLSVA-----STPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTES--SNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDN------PSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKN-----DESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSKSPDGSGAACPLQPDRENG--ATESSD--CPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEH--GPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKF--IGDNFQQTDV------AAEGDANEQLR-IQRD-DFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYP-----STPPQMAVGMPPSLIPNGVGIHSNGHVNGNVGPWF 5274
            AT +  SG + +  S+ A   E   VA     +   R+GG  QESV V++RGE++ VC+WT+  F ++KARALWS+YFEVGGYDCRLL+YP+GDSQALPGY+SIYLQ+ DPRG+SSSKWDCFASYRL +VN  D++K+I RDSWHRFS KKKSHGWCDFTPSSTV D K G++ N ++VLITA+IL+L+ESV+F+R+     NEL              GP  +VLSGKFTWKV N SLFKEMIKTQKIMSP               SSV+GV+YLSMCLESKDT+K+ V  +RSCWCLFRMSVLNQ+   NHMHRDSYGRFAADNKSGDNTSLGWNDYMKM+DFV  E G+L++DTAVFS SFHVIKE S+FSKN G ++ R+   A+K DG+ GKF WRIENFTRLKDLLKKRKITGLCIKSRRFQ+GNRDCRLIVYPRGQSQPPCHLS+FLEVTD RNT +DWSCFVSHRLSVVNQR +E+SVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQD VVFSAEVLILKETS MQE ++ + E+  S  GS   +   R +FTW+VENFL+FKEIMETRKIFSKFFQAGGCELRIGVYESFDT+CIYLESDQS+G D D+NFWVRYRMAVVN K+  +TVWKESSICTKTWNNSVLQFMKVSDM+EADAGFLVRDTVVFVCEILDCCPWFEFSDL+V  S+D+QDAL+TDP+EL+               FR+LL+RAGFHL+YGDN      PSQ Q+TLREKLLMDAGA+A FL GLRVYLDDPAKVKRLLLPTK+S +S G    KN     + SSPSLMNLLMGVKVLQQA        MVECCQP+E     D+  A   +  G         D  NG  A ES D    + ++                      + +P        +   ++    S+     S  KWPEQS+ELLGLIVNSLRAL+GAV            SAQKIALVL+KAPKHLQ DL+ALVPKLV+ SEH L A++L+ERLQ+PDAEPALR P+ GALSQL+  S++WE+VL Q+ + L +  DEPL A + F+FKAA++ Q L  AV +VR R K LG  +SP VL+ +  TV+S  DVAE +LRDID D +  +T  T      +FG++  G  + +     E+   S    +D+  L+EML++P L +EA + FERA+ARGA    SV MVLERR +QRL L  +      N   + V         G   + L  ++ D DF +VL LAE LALSRD  V+ FV  +Y ++FK Y DE Y  RML+ LV+ ATS+T   HEV+L + IL  L  EE+   RPVLSMM +VAE AN +R  LW QL A ED+I+R+R E++AE A + +EKAV+ Q+L +++    RLK+EM+AEID   REKK+++E+I+EVE+QLEW RSER++EI +L  E+K LQDRL D E QL+QLKSRKRDELK+++KEKNALAERLK AE ARKRFDE++KRYATE+VTREEIRQSLEDEVRRLTQTVGQTEG  REKEEQV R EAYI  MESKL ACQ              I TL ASL+EEMSRHAPLYGAGLEALS+ ELETL+ IH+EGLR +  LQQQ  +G+  +  + +  ++ ++  L P     +TPP +AVGM PS++ NG+ +H NGH+NG VGPW+
Sbjct:    5 ATGASGSGGAIE-SSVVAVRGEKNGVARGGENADEPREGG--QESVIVEKRGEHAAVCKWTISQFAKVKARALWSRYFEVGGYDCRLLVYPRGDSQALPGYLSIYLQVTDPRGSSSSKWDCFASYRLCVVNQKDETKSIQRDSWHRFSGKKKSHGWCDFTPSSTVLDGKGGFVVN-EAVLITAEILVLHESVSFSRE-----NELPA----------TGGPAPEVLSGKFTWKVHNLSLFKEMIKTQKIMSPVFPAGDCSLRLSVYQSSVSGVDYLSMCLESKDTEKSSV-PERSCWCLFRMSVLNQRAGMNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMADFVAPEMGYLVEDTAVFSASFHVIKESSTFSKNIGPLSARAN--AKKSDGYQGKFMWRIENFTRLKDLLKKRKITGLCIKSRRFQVGNRDCRLIVYPRGQSQPPCHLSMFLEVTDPRNTCADWSCFVSHRLSVVNQRTDERSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDMVVFSAEVLILKETSTMQELSEYEGEAAASGGGSDTGRIVNRGTFTWRVENFLAFKEIMETRKIFSKFFQAGGCELRIGVYESFDTLCIYLESDQSIGSDPDRNFWVRYRMAVVNVKHGDRTVWKESSICTKTWNNSVLQFMKVSDMVEADAGFLVRDTVVFVCEILDCCPWFEFSDLDVLISDDEQDALSTDPEELLDSDDSEGVSGDEEDIFRSLLARAGFHLSYGDNPPLLLDPSQLQITLREKLLMDAGAVAAFLAGLRVYLDDPAKVKRLLLPTKVSTTSAGGGGGKNAAGRGEASSPSLMNLLMGVKVLQQAIVDLLLDIMVECCQPSEVKKCNDVPAAKPAAAGG--------VDWRNGGSAVESRDSGLSSIDQRLEVGGDGSSGAQAVQSSDSLAVDMPVGRAAALSVSSVQSEPAASQ----ESCPKWPEQSDELLGLIVNSLRALEGAVPQGVPEPRRRPQSAQKIALVLEKAPKHLQPDLIALVPKLVDLSEHSLVAYSLLERLQRPDAEPALRLPMLGALSQLEVSSDIWEQVLQQALDILPELVDEPLAAVMSFVFKAATESQQLLRAVAAVRRRFKKLGPAVSPRVLDVVRSTVSSNADVAEALLRDIDNDSDRSETDITTAGINIVFGDNRDGDGAAQLQAAAEKVAASCWRVADVDFLVEMLTMPTLRIEAQRVFERAIARGAFGEQSVVMVLERRRSQRLILGTRMGASAGNAAASHVQDPLMPGTPGGGIDYLHPVEEDVDFPAVLQLAEALALSRDLRVREFVSTMYAVMFKVYGDEGYHERMLRGLVERATSSTSGPHEVELGMAILTFLVREEEGTARPVLSMMCKVAEAANGERNVLWQQLRAREDDIVRLRNERQAELARVSREKAVLSQRLVDADIAQGRLKAEMRAEIDRVGREKKDMAERIREVENQLEWVRSEREEEIGKLLNEKKGLQDRLRDTEAQLAQLKSRKRDELKRVMKEKNALAERLKTAESARKRFDEDIKRYATESVTREEIRQSLEDEVRRLTQTVGQTEGGLREKEEQVMRCEAYIDGMESKLHACQNY------------IQTLEASLQEEMSRHAPLYGAGLEALSLSELETLARIHDEGLRAVRLLQQQ--RGAGGAEHMANMESMANHSPLPPPLGMYATPPPIAVGM-PSIMANGMSVHGNGHINGTVGPWY 1674          

Query:  319 PSIPAAAPEDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRG----------TSSSKWDCFASYRLAIVNLADD-SKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNT-DSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------------SSVNGVEYLSMCLESKD--------TDKTVVLS----------DRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSG-----ARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTE--SSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMK-VIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSK-SPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAG---VSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDA---KFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLI------PNGVGIHSNGHVNGNVGPWFN 5277
            PS PAAA    +   +PS     +  + +V+RRG+ S  CRWT+ +FPR +AR  +S+YFEVGG+DCRLL+YP+GDSQALPGY+S+YLQ++DP+           +SSSKW+CF SYRL++ + + D SK++ RDSWHRFSSKK+SHGWCDF PS+        YLF   DS++I ADI +L E+ +F                                 G+FTWKV NF  F+EM++TQKIMSP                     S+V+G ++LS+CLESK+        +  + + S          DR CWCLFR+S+LNQKP  +H+H+DSYGRF ADN      SLGW DY+KM DF+  + G+LLD   VFS S HVIKE +SF+++  +I G SG+G     ARK DGH GKF WRIENFTRLK+LLKKRKITGLCIKSR+FQ+GNRDCRLIVYPRGQSQPPC+LSVFLEVTD RN SS+WSCFVSHRLSV+NQ++EE+++ KESQNRYSK+AKDWGWREFVTLT LFDQD+GFLVQDTVVF+AEVLILKET+ +QE +D+D+E  SS +G QID   KR SFTWKVENFLSFK+IMETRKIFSK+FQAGGCELRIGVYESFDTICIYLESDQ  G D DKNFWV Y+MA++NQKN AKTV KESSICTKTWNNSVLQFMKVSD+L+ DAGFLVRDTV+FVCEI+DCCPWF+FSDLEV AS+DDQD L+TDPD+ +               FRNLLSRAGF LTYG+N +QPQVTLREK+L DA AIAGFLTGLRVYLD+PAKVKR+LLPTK+S  + G K V K D SS SL++LLMGV VL+QA        MVECCQP+E       S A+SK SPD +GA+ P + + E   TE +     ERL                   T   +P + L  +   PPE S       E+    S+TKWPEQSEELLGLIV+SLRALD AV            S QKIALVL+K+PK LQ DLVALVPKLV+ SEH LAA AL++ LQKPD EP+LR PVF ALS+L+   ++W++    + E L DSNDEPLV  I ++ KAASQCQH+ +A R+VR RLK+LG ++  CVL+FLS+TV+SW DVA+ +L+DID D E   +C +++       E    +E  H +  QA       SD++ILIEMLSIP L VE SQ  +RA+ RGA     VAMVLERR + RL+L +     + D+ Q   V  +G   E L +Q DDFTSVL L E L+LS +  V+ FV+MLY ++FK Y ++ YR R+LK LV+ AT+T+DS   VD+D+D+LV L  EE  I RPVL+M+REVAE+A  DRA LWHQ+CA+EDE +R+RE+   E     KEK V++Q+L ESEA N  L+SE+KAE DCF REKKELSEQ+ E+E+QLEW RSE+D++I +L  ++K L DRLH+AETQLSQ K+ KR+ELKK+ KEKNALAERLK  E +RKR D+E K++  E  TREEIR+SLE EVRRLTQTVGQTEGEK+EKE+Q+ R EAYI  MESKLQ C            QQ IHTL  S++EEM+RHAP+YG G+EALS+ ELETL+ IHE GLRQIH +  +QRKG   SS  +S  +L H  GLY S+PP MAVG+P SLI      PNG GIH NGH+NG++G WFN
Sbjct:    6 PSPPAAAAAAAADDPSPSASDSPSA-TFSVERRGDASASCRWTLPDFPRTRARTFYSRYFEVGGFDCRLLLYPRGDSQALPGYLSLYLQVLDPKTPTSSSSATTTSSSSKWECFLSYRLSVAHPSPDPSKSLARDSWHRFSSKKRSHGWCDFAPSAAA-----AYLFPPHDSLVIAADISVLAEAASFAE-----------------------------ADGRFTWKVLNFGTFREMVRTQKIMSPAFFPAANAGGSDCGLRISVYQSNVSGADHLSVCLESKEPLVQATSGSSASALPSSAGGSGMPDGDRGCWCLFRVSILNQKPGGSHIHKDSYGRFGADN-----ASLGWGDYIKMDDFLAADGGYLLDGAVVFSASVHVIKESNSFTRSLPMIAGMSGAGSGRAGARKSDGHFGKFVWRIENFTRLKELLKKRKITGLCIKSRKFQVGNRDCRLIVYPRGQSQPPCNLSVFLEVTDPRN-SSEWSCFVSHRLSVINQKLEERTIVKESQNRYSKSAKDWGWREFVTLTVLFDQDAGFLVQDTVVFAAEVLILKETATIQELSDEDSEACSSGSGCQIDSLPKRPSFTWKVENFLSFKDIMETRKIFSKYFQAGGCELRIGVYESFDTICIYLESDQPSGFDPDKNFWVHYKMAIINQKNSAKTVCKESSICTKTWNNSVLQFMKVSDLLDTDAGFLVRDTVIFVCEIIDCCPWFDFSDLEVLASDDDQDDLSTDPDDFIESEDSEDMSGDEEDMFRNLLSRAGFSLTYGENYTQPQVTLREKILTDASAIAGFLTGLRVYLDNPAKVKRMLLPTKVSTRAGGKKDVSKCDSSSTSLISLLMGVSVLKQAIIDLLLDIMVECCQPSEERPAYVSSSASSKTSPDSNGASSPPELNVEGELTECAFSNKYERLKPGNDDIHHRLSVQNTDKCTN-DIPARVLE-QSCSPPEVSGADLLEDEDSDQASRTKWPEQSEELLGLIVSSLRALDSAVPHGCPEPRRRPQSVQKIALVLEKSPKKLQPDLVALVPKLVDSSEHSLAACALLDHLQKPDTEPSLRLPVFNALSELEFDCDIWKQASFHALELLADSNDEPLVEAITYVLKAASQCQHIAQAARAVRWRLKDLGTEVPLCVLDFLSKTVHSWSDVADALLKDIDYDCEPDSSCLSMSCSTSSTDEFS--AEGMHSLQGQAVHGKDHLSDVFILIEMLSIPRLFVEVSQVLQRALLRGAFGLQLVAMVLERRHSHRLSLKSGTGTMVNDS-QNKQVLLDGQF-EHLPVQEDDFTSVLALGEVLSLSTETRVQDFVRMLYAIIFKIYTEDHYRYRILKGLVERATNTSDSCRAVDIDMDVLVFLVKEEFGIARPVLNMLREVAEVAQADRANLWHQICATEDENMRLREDMDMEQTKFTKEKDVLMQQLIESEAANAHLRSELKAEKDCFVREKKELSEQMLEMENQLEWVRSEKDEQIVKLTADKKNLHDRLHEAETQLSQFKAWKREELKKITKEKNALAERLKGVEASRKRVDDEFKQFVAEAQTREEIRKSLEGEVRRLTQTVGQTEGEKKEKEDQITRCEAYIDGMESKLQVC------------QQYIHTLETSIQEEMARHAPVYGVGVEALSLDELETLTNIHERGLRQIHAI--RQRKG---SSHRLSAPSLPHVPGLY-SSPPSMAVGLPSSLIPTSSVAPNGAGIHGNGHMNGSMGSWFN 1665          

Query:  319 PSIPAAAPEDLSVASTPSRDGGGAQESV-TVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRG----------TSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNT-DSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP----------------------SSVNGVEYLSMCLESKD------------------TDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSG-----ARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTE--SSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMK---VIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSK-SPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPG--KPICPPETSAG---VSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLI------PNGVGIHSNGHVNGNVGPWFNHS 5283
            P+  AAA         PS     +  +  TVDRRG+ S  CRWT+ +FPR +AR  +S+YFEVGG+DCRLL+YP+GDSQALPGY+S+YLQ++DP+           T+SSKWDCF SYRL++V+  D +K++ RDSWHRFSSKK+SHGWCDF PSS        +LF   D+++I ADI +L+E+ +F                                 G+FTWKV NF LF+EMI+TQKIMSP                      S+V+G E+LS+CLESK+                  T   V   DR CWCLFR+S+LNQ+   +H+H+DSYGRF AD+      SLGW +Y+KM +F+  +SG+L+D   VFS S HVIKE +SF+++  ++ G  G+G     ARK DGH GKF WRIE+FTRLK+LLKKRKI GLCIKSRRFQ+GNRDCRLIVYPRGQSQPPCHLSVFLEVTD RNT+++WSCFVSHRLSV+NQ++EEKS+TKESQNRYSK+AKDWGWREFVTLTSLFDQD+GFLVQDTVVFSAEVLILKET+ MQE TD+D+E  SS  G QI+   KR SFTWKVENFLSFKEIME+RKIFSKFFQAGGCELRIGVYESFDTICIYLESDQS G D DKNFWV Y+MA+VNQKN AKTV KESSICTKTWNNSVLQFMK SDM++ DAGFLVRDTV+F CEI+DCCPWF+FSDLEV+AS+DDQD L+TDPDELV               FR+LLSRAGF LTY DN +QPQVTLREK+L DA AIAGFLTGLRVYLD+PAKVKR+LLPTK+S  S G K      +  SS SL++LLMGV  L+QA        MVECCQP+E +S    S A++K SPD +GA+ P +   E   TE     AC  +                   T +      +        PPETSA      E   L S +KWPEQSEELLGLIVNSLRALD AV            + +KIALVLDKAPK L  DL++LVPKLV+ SEH LAA AL++ LQKPDAEP+LR PVFGALS+L+  S++W++    + E L DSNDE LVA I ++ KAASQCQHL  AVR++R RLK+LG ++  CVL+FLS+T+ +  DVAE IL+DID D E  + C +  S        G  +E  +   EQA       SD++ LIEMLS+P L VE +Q FERA+ RG+     VAMVLERR +   +  +  + ++ Q   V  +G   E L +Q +DFTSVL L E L+LS +  V+ FV+MLY ++FK YA++ YR R+LK LV+ AT+T+D+   VD+D+D+LV L  EE  I RPVL+MMREVAE+A  DRA LWHQ+CA+EDE IR+RE+ + E      EK  + Q+ +E EAT   LKSE+KAE D F REKK LS+Q++E+E+QLEW RSE+ D+I +L  E++ L DRL+DAE+QLS +K+RKR+ELKK+ KEKN LAERLKNAEG+RKRFD+ELKRYA E  TREEIR+SLE+EVRRLTQTVGQTEGEK+EKEEQ+ R EAYI  MESKLQ C            QQ I TL  SL+EEM+RHAPLYG G+E+LS++ELE L+ IHE+ LRQI  +  QQRKG   SS L+   AL H   L+ S+PP +AVG P S I      PNG GIH NGH+NG  G WFN S
Sbjct:    3 PTTSAAAAAAAVTTDDPSPSPSDSTSATFTVDRRGDASASCRWTLPDFPRTRARTFYSRYFEVGGFDCRLLLYPRGDSQALPGYLSLYLQVLDPKTPVSSSSSTTTTTSSKWDCFLSYRLSVVHPTDPAKSLGRDSWHRFSSKKRSHGWCDFAPSSAA-----AFLFQPHDALVIAADISVLSEAASFAD-----------------------------ADGRFTWKVLNFGLFREMIRTQKIMSPAFFPAAASAGGTDCGLRISVYQSNVSGAEHLSVCLESKEPVVQVASGSSTSALTSGGTGSGVPDGDRGCWCLFRISILNQRSGGSHIHKDSYGRFGADS-----ASLGWGEYIKMDEFLAADSGYLVDGAVVFSASVHVIKESNSFTRSLPMVPGICGAGGGRAGARKSDGHFGKFVWRIESFTRLKELLKKRKIAGLCIKSRRFQVGNRDCRLIVYPRGQSQPPCHLSVFLEVTDPRNTTTEWSCFVSHRLSVINQKVEEKSITKESQNRYSKSAKDWGWREFVTLTSLFDQDAGFLVQDTVVFSAEVLILKETATMQELTDEDSEICSSTYGCQIEALPKRPSFTWKVENFLSFKEIMESRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSSGYDPDKNFWVHYKMAIVNQKNSAKTVCKESSICTKTWNNSVLQFMKTSDMVDTDAGFLVRDTVIFTCEIIDCCPWFDFSDLEVWASDDDQDELSTDPDELVDSEDSEDMSGDEEDIFRSLLSRAGFSLTYEDNYTQPQVTLREKILTDATAIAGFLTGLRVYLDNPAKVKRMLLPTKVSTKSGGKKDASKCDSSSSSTSLISLLMGVSALKQAIIDLLLDIMVECCQPSEESS----SSASTKASPDSNGASSPPELSVEGELTEC----ACSDVYARVESNSDDIRDSPAMHNTDLAATEIAVNNLEHSCFPPETSAADLPADEGPELASWSKWPEQSEELLGLIVNSLRALDSAVPHGCREPRRRPQAVRKIALVLDKAPKQLHQDLISLVPKLVDGSEHSLAACALLDHLQKPDAEPSLRLPVFGALSELELESDIWKQASVHALELLSDSNDESLVAAITYVLKAASQCQHLSVAVRAIRWRLKDLGTEVPHCVLDFLSKTIQTQPDVAEAILKDIDSDCEPENNCLSSTSPCSTCSTDGLSAEGMYSWQEQAVHGRSHLSDVFALIEMLSMPGLFVEVAQVFERALLRGSFGLQLVAMVLERRHSYSSSSKSGSVVNDSQNKQVLLDGQL-EPLSVQENDFTSVLALGEVLSLSTETKVQDFVRMLYAIIFKIYAEDHYRYRILKGLVERATNTSDNCRAVDIDMDVLVFLVKEEYGIARPVLNMMREVAEVAQADRANLWHQICATEDENIRLREDMEMEQTNFTNEKIALNQQRTELEATIGGLKSELKAERDRFTREKKALSDQMREIENQLEWVRSEKGDQIVKLTAEKRNLHDRLNDAESQLSLVKARKREELKKVTKEKNTLAERLKNAEGSRKRFDDELKRYAAETQTREEIRKSLENEVRRLTQTVGQTEGEKKEKEEQITRCEAYIDGMESKLQVC------------QQYIRTLETSLQEEMARHAPLYGVGVESLSLEELEALANIHEQSLRQIKAI--QQRKG---SSHLLGGPALSHIPALF-SSPPSVAVGPPSSRIPTSPMAPNGAGIHGNGHLNGATGRWFNPS 1665          

Query:  280 ATSSLNSGASEKLPSIPAAAP-----EDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGA-RKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSK-SPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVS-ENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVNGNVGPWFNHS 5283
            ++S++ S + +  P I   +P     +D S+A+  SRDG G QESVTVDRR ++S VC+WTV NFP+IKARALWSKYFEVGG+DCRLLIYPKGDSQALPGYIS+YLQIMDPRG+SSSKWDCFASYRLAIVN ADDSK+IHRDSWHRFSSKKKSHGWCDFTPS+T+FDSK GYLFN DSVLITADILILNESVNFTRD    NNELQ           VAGPVSDVLSGKFTWKV NFSLFKEMIKTQKIMSP               SSVNGVEYLSMCLESKDT+K VV SDRSCWCLFRMSVLNQKP  NHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDF+G++SGFL+DDTAVFSTSFHVIKEFSSFSKNGGLI  R GSG  RK DGH+GKF WRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTD+RNTSSDWSCFVSHRLSVVNQRME+KSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETS M + TDQD+ESSN+GSQIDK GKRSSFTW+VENF+SFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVG D DKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEV ASEDDQDALTTDPDEL+               FRNLLSRAGFHLTYGDNP+QPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGS+DG KV K DESSPSLMNLLMGVKVLQQA        MVECCQP+EG S  D SD NSK SP GSGA  PL+ DRENGATES++ P  ERL                  + G  VP K +PG+PI PPETSAG S EN +LRSKTKWPEQSEELLGLIVNSLRALDGAV            SAQKIALVLDKAPKHLQ DLVALVPKLVEHSEHPLAA AL++RLQKPDAEPALR PVFGALSQL+CGSEVWER+L QSFE L DSNDEPL ATI+FIFKAASQCQHLPEAVRS+RV+LK+LG ++SPCVL+FL++TVNSWGDVAETILRDIDCDD+FGD CST+  GLFLFGE+GP SER H +DEQAF ++R FSDIY+LIEMLSIPCLAVEASQTFERAVARGA VA SVAMVLE RLAQRLN +++F+ ++FQ TDV  EG+ NEQLR QRDDF+SVLGLAETLALSRDP VKGFVK+LYT+LFKWYADE+YRGRMLKRLVD ATSTTDS+ E+DL+L+ILV L  EEQEI+RPVLSMMREVAELANVDRAALWHQLC SEDEIIRMREE+KAE + +VKEKA+I Q+LSESEAT+ RLKSEM+AE D FAREKKELSEQIQEVESQLEW RSERD+EI +L +E+KVLQDRLHDAE QLSQLKSRKRDELK++VKEKNALAERLK+AE ARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVAR EAYI  MESKLQAC            QQ IHTL ASL+EEMSRHAPLYGAGLEALSMKELETL+ IHEEGLRQIH +  QQ KGSP+ SPLVSPH LQH+HGLYP  PP MAVG+PPSLIPNGVGIHSNGHVNG VG WFNH+
Sbjct:   18 SSSTVPSSSEQSQPPIATPSPSPSMGDDPSLAA--SRDGHG-QESVTVDRRTDFSAVCKWTVHNFPKIKARALWSKYFEVGGFDCRLLIYPKGDSQALPGYISVYLQIMDPRGSSSSKWDCFASYRLAIVNHADDSKSIHRDSWHRFSSKKKSHGWCDFTPSTTLFDSKSGYLFNNDSVLITADILILNESVNFTRD----NNELQSASSMASMV--VAGPVSDVLSGKFTWKVHNFSLFKEMIKTQKIMSPVFPAGECNLRISVYQSSVNGVEYLSMCLESKDTEKAVV-SDRSCWCLFRMSVLNQKPGLNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFIGSDSGFLVDDTAVFSTSFHVIKEFSSFSKNGGLIGVRGGSGGTRKSDGHLGKFTWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDSRNTSSDWSCFVSHRLSVVNQRMEDKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSTMLDLTDQDSESSNSGSQIDKIGKRSSFTWRVENFMSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGSDPDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVLASEDDQDALTTDPDELIDSEDSEGISGDEEDIFRNLLSRAGFHLTYGDNPAQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSNDGKKVTKTDESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPSEGNSNDDSSDENSKLSPGGSGAVSPLESDRENGATESAEFPVYERLDSGVYESTNVSAVQSSD-MNGTVVPEKAVPGQPISPPETSAGGSIENASLRSKTKWPEQSEELLGLIVNSLRALDGAVPQGCPEPRRRPQSAQKIALVLDKAPKHLQPDLVALVPKLVEHSEHPLAACALLDRLQKPDAEPALRIPVFGALSQLECGSEVWERILFQSFELLSDSNDEPLAATINFIFKAASQCQHLPEAVRSIRVKLKHLGAEVSPCVLDFLNKTVNSWGDVAETILRDIDCDDDFGDNCSTIPCGLFLFGENGPTSERLHAIDEQAFCATRHFSDIYLLIEMLSIPCLAVEASQTFERAVARGAFVAQSVAMVLESRLAQRLNFNSRFVAESFQHTDVVVEGETNEQLRAQRDDFSSVLGLAETLALSRDPRVKGFVKVLYTILFKWYADESYRGRMLKRLVDRATSTTDSSREIDLELEILVILVCEEQEIVRPVLSMMREVAELANVDRAALWHQLCTSEDEIIRMREERKAEISNLVKEKAIISQRLSESEATSNRLKSEMRAEADRFAREKKELSEQIQEVESQLEWLRSERDEEITKLTSEKKVLQDRLHDAEAQLSQLKSRKRDELKRVVKEKNALAERLKSAEAARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARCEAYIDGMESKLQAC------------QQYIHTLEASLQEEMSRHAPLYGAGLEALSMKELETLARIHEEGLRQIHAI--QQHKGSPAGSPLVSPHTLQHSHGLYPPAPPPMAVGLPPSLIPNGVGIHSNGHVNGAVGSWFNHN 1683          

Query:  433 VCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSS-DGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDAN-SKSPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVNGNVGPWFNHS 5283
            + +WTV +F +I+ R+ +S YF +GG+D R ++YP+GD  ALPG+ S+YLQ+MDPR   S+K+DCF SY L  +N  DDS ++ R+SW RFS KKKSHGW DF  SS V D+K G+L N D++ I ADI +LN+S+  ++D+N   ++L            ++G  SDVL G+ TW+++NF +FK++ KTQK++SP               S +NGVEYLSM LE ++        DR+CWCLFR+SVLNQKP  N  +++SYGRF  D   GD  SLGW DYMKMS  V +E+GF +D T VFSTSFHVIKEFS+FSKNGG++ GR  S ARK DG+ GKF W+IENFT+LKDLLK+++I  LCIKSR+FQI NRDC L++YPRGQSQPPC+LS+FLEVTD+ NTS DWSCFV +R+SV+NQ+ EE+S+TKESQ+RYSK+AK++GW EFVTL SLFDQDSG LVQDT+ FS ++LILKETS++++     TESSNA  +ID++ K  SFTWKVENFLSFKEIM+ RKIFSKFF+ GGCELRIGVYESFDT+  YLE D S   D DKNFWV YRM VVNQK+  K++WKESS+CTKTW++S LQFMKV+D+LE  AG+LVR+TV+FVCEILD CPWFEFSDLEV A   +QD  T++ D+LV                ++LLS AGFHL  G+NPSQP V  +E   + A  +AGFL  L   L+D  K K  L P K S S+ +  +V   DESSPS    +  VKVLQ A        MV+ CQ ++  S  D  D     S +   A    +   ENG    SDC                        + G G             P+               +WP QSEELL LIVNSL+A D                 QK+  +L KAPK LQ DLV L+PKL++ SEHPL A AL+++LQK DAEPAL+ PV  A+S++  GSEV E VL  +   L    DEPL A IDF+FKAAS+CQ +  AVR VR RL++LG ++S CVLE LS+ VNS  ++AET+LRDID   E    C                      V+EQ  +    FSDIY+L+EMLS+PCL+VE SQ FERAV RG I+  S+AMVLERR AQ LN D+          D+A E +    L  Q  DFT VL LA TLALSRD  V GFV+ LY +LFK +A E    ++LK LVD A +  +   EV++DLDIL  L  EEQ I + VL+MMREV EL+NVDRA L  QL A E E I  +E ++AE + M++EKA++L +LS+SEAT   LKSE++   + FA+EK E + Q++EV++++E  RSERD +I +L+ E+K+ QDRLHDAE Q S LK +K DELK+ ++EKN LAERLK AE    +FDEELKRYA+E V REE+++ L++EV+   Q V QTE EK +KEE +A YEAYI  ME+KL  CQT             I +L  +L++EM +HAPLYG GLE +S++EL+TLS IHEEGLR IH+LQQQ  KG P  +PL+S                     +PP L+ +GV  H NGHVNG   P  N+S
Sbjct:    1 MAKWTVPDFSKIRGRSHYSPYFTIGGFDFRFMVYPRGDLVALPGHCSLYLQVMDPR---SAKFDCFVSYTLKFLNHIDDSMSVCRESWLRFSPKKKSHGWSDFAQSSIVLDTKFGFLVN-DTMTILADIRVLNDSLTVSQDNNETKSQLAT----------ISGSGSDVLDGRITWRLKNFVVFKDIFKTQKLVSPAFQVGECSVRICIYRSWINGVEYLSMSLEGRE-----FTPDRNCWCLFRVSVLNQKPGLNQFYKESYGRFGPDTNGGDGCSLGWIDYMKMSQLVESENGFFIDGTLVFSTSFHVIKEFSNFSKNGGVLAGRGTSVARKSDGYTGKFTWKIENFTKLKDLLKRKRIKNLCIKSRKFQIANRDCHLLLYPRGQSQPPCYLSMFLEVTDSLNTSYDWSCFVHYRVSVINQKGEERSITKESQSRYSKSAKEFGWPEFVTLASLFDQDSGLLVQDTIAFSVDLLILKETSLLEDC----TESSNACFEIDQDKKLGSFTWKVENFLSFKEIMQNRKIFSKFFEVGGCELRIGVYESFDTVSTYLECDPSAVSDPDKNFWVSYRMGVVNQKDHNKSLWKESSLCTKTWSSSTLQFMKVADLLEVGAGYLVRETVIFVCEILDYCPWFEFSDLEVLAPLCNQDT-TSESDKLVNSDECEVLSGDKTDKLKDLLSSAGFHLINGNNPSQPLVIPKETAPLIAAKLAGFLINLCCDLNDSVKAKHWLPPVKFSASNEEKQEVTVGDESSPSAF-FMRKVKVLQHATIDLLLDIMVKFCQSSDSRSSEDFYDIGLGPSLNSHKAVSKSESYVENG---GSDC--------------------VHFLIYGRG-------------PKVDEKTCTCSIRFMGIEWPGQSEELLELIVNSLKAKDVTFSQVFSELRQRTQFTQKVLFILTKAPKSLQPDLVTLIPKLIDLSEHPLVACALLDQLQKSDAEPALQLPVLAAISKMQFGSEVAECVLVHASSLLGGLKDEPLAAAIDFLFKAASRCQKILLAVRVVRARLQSLGAEVSACVLEVLSKAVNSCSEIAETMLRDIDSVPEPDGKCL---------------------VEEQLLQ----FSDIYLLVEMLSMPCLSVEVSQAFERAVVRGIIMDQSMAMVLERRHAQSLNFDSVSSAQKNLHKDMALE-EKTGSLPAQEVDFTLVLCLARTLALSRDSRVYGFVRTLYAILFKMFAKEDDHRKILKGLVDRAITPAEHCCEVNIDLDILALLVHEEQGISKQVLNMMREVVELSNVDRATLRRQLRAKEKENIHTQEIRQAELSNMLREKAILLDRLSDSEATIDHLKSEVRLGKEHFAQEKMEFTGQMREVKNRIEQLRSERDSKIAKLSMEKKLYQDRLHDAEAQQSLLKFQKHDELKRAIREKNVLAERLKVAEAMINKFDEELKRYASEAVNREEVQKLLQNEVQWFKQKVEQTELEKMQKEEHIASYEAYITSMEAKLNECQTY------------ISSLEVALRDEMLQHAPLYGVGLEDMSVEELDTLSSIHEEGLRAIHSLQQQ--KGIPRGNPLMS---------------LSTTAALPPPLVSDGVH-HRNGHVNGTDRPPLNYS 1517          

Query:  496 FEVGGYDCRLLIYPKGDSQAL-PGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDS---WHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMI-----------KTQKIMSPSSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNT-SLGWNDYMKMSDFVGTESGFLLDDTAVFSTSF-----------HVIKEFSSF-------------SKNGGLITGRSGSGARKLDG-HMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRG--QSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNR---YSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFD------TICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTW---NNSVLQF---MKVSDMLEADAGFLVRDTVVFVCEIL 2283
            FEVGGY   L IYP G+ ++   G+IS+YL+I + +      W+   +++L + N   +     +D+      F++ K   G+  F     + D + GYL + DS +  A++ ++  S             L                + D + G FTW ++NFS   + +           K + ++ P   N  +  S+ L  + T++   L  R  +  F + + +Q    + +   S+ +  A     D   + G+ + + +SD       FLL+D+ + + S            H I+ F                + +   I   + S +R L       + +R+E+ + L +   ++  +G       F++G    RL +YP G  +S    H+S++LE++DA+     W   V+ +L V N   E+    +++  +   ++      G+ +F++L  L D  +G+L+ D+ +F AEV ++K +                 S I K+    +FTW +ENF +  E      ++S+ F     + ++ +Y   +      ++C++LE          +  ++ + + + +Q N             K W   +N    F   + +SD+ +    FL+ D+++   +IL
Sbjct:   60 FEVGGYKWSLCIYPNGNKKSDGEGHISLYLEISEAQNLPLG-WEVTVNFKLFVFNHIHEKYLTVQDADGKVRHFNAMKTRCGFAQFLSLDVLKDPRNGYLMD-DSCIFGAEVFVIKYS--------GKGESLSM--------------IKDPVDGTFTWTIENFSALNQEVLDSEIFTVKELKWRLVLYPKGNNKAKNKSLSLFLELTNRET-LHQRKLYTAFELLIKDQ--CNDEIVMPSHVKSNAKVWFRDTIENWGFPNMVSLSDLNDKSKYFLLNDSLISTPSAVFFPSKSTLPTHFIQSFGDQRFPAMADEKPPEKTLHPTSICNSTTSISRTLRSIKPAHYLFRVESVSVLLNTDIEKYESG------SFKVGGYRWRLCLYPNGNKKSGGEDHISLYLEISDAQKLPVGWEVTVNFKLFVFNHIHEKYLTVQDADGKVRDFNVMKSRCGFAQFLSLDVLKDPCNGYLMDDSCIFGAEVFVIKYSG-----------KGECLSMI-KDPDDGTFTWVIENFSTLNE----EVLYSETFTIKEIKWKLSLYPKGNGKVKNKSLCLFLELADCETLHHQRKLYMEFELLIKDQCNDENVEPSHVKSNAKVWFCDSNKEWGFADMVSLSDLNDKSKDFLLNDSLIVEAKIL 664          

Query: 1033 GVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGD----NTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQ-PPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQ----RMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLIL 1821
            G +++S+ LE  D  K  V  + +    F++ V N      H+H        AD K  D     +  G+  ++ +       +G+L+DD+ +F     VIK            +G+    +   D   G F W IENF+ L + +         + S  F I     +L +YP+G  +     L +FLE+ D          ++   L + +Q     +E   V   ++  +  + K+WG+ + V+L+ L D+   FL+ D+++  A++L++
Sbjct:  423 GEDHISLYLEISDAQKLPVGWEVTV--NFKLFVFN------HIHEKYLTVQDADGKVRDFNVMKSRCGFAQFLSLDVLKDPCNGYLMDDSCIFGAEVFVIK-----------YSGKGECLSMIKDPDDGTFTWVIENFSTLNEEV---------LYSETFTIKEIKWKLSLYPKGNGKVKNKSLCLFLELADCETLHHQRKLYMEFELLIKDQCNDENVEPSHVKSNAKVWFCDSNKEWGFADMVSLSDLNDKSKDFLLNDSLIVEAKILLM 666          

Query: 1486 KSRRFQIGNRDCRLIVYPRG--QSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQN---RYSKAAKD-WGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFS 1980
            +S  F++G     L +YP G  +S    H+S++LE+++A+N    W   V+ +L V N  + EK +T +  +   R+  A K   G+ +F++L  L D  +G+L+ D+ +F AEV ++K       ++ +    S     +D      +FTW +ENF +  + +   +IF+
Sbjct:   56 ESGSFEVGGYKWSLCIYPNGNKKSDGEGHISLYLEISEAQNLPLGWEVTVNFKLFVFNH-IHEKYLTVQDADGKVRHFNAMKTRCGFAQFLSLDVLKDPRNGYLMDDSCIFGAEVFVIK-------YSGKGESLSMIKDPVD-----GTFTWTIENFSALNQEVLDSEIFT 213          

Query:  331 AAAPEDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDS 858
            A  P+ + VA     D   A ++ TV+     S    WT++NF R+  + L+S  F VGGY  R+LI+PKG++     ++S+YL + D   T    W  +A + LA++N   +  TI +D+ H+F++++   G+  F P   ++D   GYL N D+ ++ AD+ +      +T DS
Sbjct:   24 ADGPQPMEVAQP---DTASAVDAQTVE--DPPSARFTWTIENFSRLNTKKLYSDVFYVGGYKWRVLIFPKGNN---VDHLSMYLDVAD-SATLPYGWSRYAQFSLAVINQIHNKFTIRKDTQHQFNARESDWGFTSFMPLGELYDPARGYLVN-DTCIVEADVAVRRVIDYWTHDS 189          

Query: 1393 DGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLI 1818
            D    +F W IENF+RL    KK       + S  F +G    R++++P+G +    HLS++L+V D+      WS +    L+V+NQ   + ++ K++Q++++    DWG+  F+ L  L+D   G+LV DT +  A+V +
Sbjct:   48 DPPSARFTWTIENFSRLNT--KK-------LYSDVFYVGGYKWRVLIFPKGNNVD--HLSMYLDVADSATLPYGWSRYAQFSLAVINQIHNKFTIRKDTQHQFNARESDWGFTSFMPLGELYDPARGYLVNDTCIVEADVAV 178          

Query: 1393 DGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLI 1818
            D    +F WRIENF+RL    KK         S  F +G    R++++P+G +    HLS++L+V D+ +    WS +    L+VVNQ   + +V K++Q++++    DWG+  F+ L+ L+D   GFLV DT +  AEV +
Sbjct:   49 DPPTSRFTWRIENFSRLNT--KKHY-------SENFIVGGYKWRVLIFPKGNNVE--HLSMYLDVADSSSLPYGWSRYAQFSLAVVNQIHNKYTVRKDTQHQFNARESDWGFTSFMPLSELYDPGRGFLVSDTCIVEAEVAV 179          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDS 858
            W ++NF R+  +  +S+ F VGGY  R+LI+PKG++     ++S+YL + D        W  +A + LA+VN   +  T+ +D+ H+F++++   G+  F P S ++D   G+L  +D+ ++ A++ +      +T DS
Sbjct:   57 WRIENFSRLNTKKHYSENFIVGGYKWRVLIFPKGNNVE---HLSMYLDVADSSSLPYG-WSRYAQFSLAVVNQIHNKYTVRKDTQHQFNARESDWGFTSFMPLSELYDPGRGFLV-SDTCIVEAEVAVRRVVDYWTYDS 190          

Query: 1843 EFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVY---ESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKES--SICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEI 2280
            E   Q+  +S   +Q  ++   S FTW++ENF      + T+K +S+ F  GG + R+ ++    + + + +YL+   S       + + ++ +AVVNQ +   TV K++      +  +     FM +S++ +   GFLV DT +   E+
Sbjct:   31 EVVAQEETTSTVENQPVEDPPTSRFTWRIENF----SRLNTKKHYSENFIVGGYKWRVLIFPKGNNVEHLSMYLDVADSSSLPYGWSRYAQFSLAVVNQIHNKYTVRKDTQHQFNARESDWGFTSFMPLSELYDPGRGFLVSDTCIVEAEV 177          

Query: 1393 DGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILK 1824
            D    +F W IENF+RL    KK         S  F +G    R++++P+G +    HLS++L+V D+      WS +    LSVVNQ   + S+ K++Q++++    DWG+  F+ L+ L+D   G+LV DT +  AEV + K
Sbjct:   50 DPQTSRFTWTIENFSRLNT--KKHY-------SEIFVVGGFKWRVLIFPKGNNVD--HLSMYLDVADSATLPYGWSRYAQFSLSVVNQIHNKYSIRKDTQHQFNARESDWGFTSFMPLSDLYDPGRGYLVNDTCIIEAEVAVRK 182          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDS 858
            WT++NF R+  +  +S+ F VGG+  R+LI+PKG++     ++S+YL + D   T    W  +A + L++VN   +  +I +D+ H+F++++   G+  F P S ++D   GYL N D+ +I A++ +      +T DS
Sbjct:   58 WTIENFSRLNTKKHYSEIFVVGGFKWRVLIFPKGNNV---DHLSMYLDVADS-ATLPYGWSRYAQFSLSVVNQIHNKYSIRKDTQHQFNARESDWGFTSFMPLSDLYDPGRGYLVN-DTCIIEAEVAVRKILDYWTYDS 191          

Query: 1843 EFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVY---ESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESS--ICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEI 2280
            E   Q   SS   +Q  ++ + S FTW +ENF      + T+K +S+ F  GG + R+ ++    + D + +YL+   S       + + ++ ++VVNQ +   ++ K++      +  +     FM +SD+ +   G+LV DT +   E+
Sbjct:   32 EVVAQADASSAVENQPVEDPQTSRFTWTIENFSR----LNTKKHYSEIFVVGGFKWRVLIFPKGNNVDHLSMYLDVADSATLPYGWSRYAQFSLSVVNQIHNKYSIRKDTQHQFNARESDWGFTSFMPLSDLYDPGRGYLVNDTCIIEAEV 178          

Query: 1294 VFST--SFHVIKEFSSFSKNGGLITGRSGSGARKLDG-HMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRG--QSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNR---YSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFD------TICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQ------FMKVSDMLEADAGFLVRDTVVFVCEIL 2283
            +FST  SFH+   F    +  G+   +  + +R L       + +R+E+ + L D   ++  +G       F++G    RL +YP G  +S    H+S++L ++D +N    W   VS +L V N   EE    +++  +   ++      G+ +F+ L  L D  +G+L+ D+ +F AEV ++K +                 S I K     +FTW +ENF   K+      I+S+ F     + ++ VY   +      ++ ++LE          +  +  + + V  Q N          +  +TW    ++       + +SD+ +    F++ DT++   +I+
Sbjct:   57 LFSTKSSFHI---FFGDQRFAGMADEKLQAISRTLRSIQPAHYLFRVESMSVLLDTSIEKYESG------SFEVGGYKWRLCLYPNGNKKSDGDGHISLYLVISDTQNLPLGWEVTVSFKLFVFNHIHEEYLTVQDTDGKVRHFNVMKTQCGFAQFLPLDVLTDPCNGYLMDDSCIFGAEVFVIKYSG-----------KGECLSMI-KEPDDGTFTWMIENFSRLKQ----EAIYSEIFTVKDFKWKLVVYPKGNYKAKNKSLSLFLELANRGTLHHQRKLYTEFELLVKEQCNGGHVKPSHVKLNGQTWFCDSIKDWGFSNMISLSDLKDKSNHFILNDTLIVEAKIM 381          

Query: 1153 NHMHRDSYGRFAADNKSGD----NTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCH-LSVFLEVTDARNTSSDWSCFVSHRLSVVNQ----RMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLIL 1821
            NH+H +       D K        T  G+  ++ +       +G+L+DD+ +F     VIK    +S  G  +     S  ++ D   G F W IENF+RLK            I S  F + +   +L+VYP+G  +     LS+FLE+ +          +    L V  Q     ++   V    Q  +  + KDWG+   ++L+ L D+ + F++ DT++  A+++++
Sbjct:  172 NHIHEEYLTVQDTDGKVRHFNVMKTQCGFAQFLPLDVLTDPCNGYLMDDSCIFGAEVFVIK----YSGKGECL-----SMIKEPDD--GTFTWMIENFSRLKQE---------AIYSEIFTVKDFKWKLVVYPKGNYKAKNKSLSLFLELANRGTLHHQRKLYTEFELLVKEQCNGGHVKPSHVKLNGQTWFCDSIKDWGFSNMISLSDLKDKSNHFILNDTLIVEAKIMLM 383          

Query:  496 FEVGGYDCRLLIYPKGDSQA-LPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDS---WHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEM-----------IKTQKIMSPSSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQ------KPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAV 1296
            FEVGGY  RL +YP G+ ++   G+IS+YL I D +      W+   S++L + N   +     +D+      F+  K   G+  F P   + D   GYL + DS +  A++ ++  S                              + +   G FTW ++NFS  K+             K + ++ P      +  S+ L  +  ++  +   R  +  F + V  Q      KP  +H+  +    F    K       G+++ + +SD     + F+L+DT +
Sbjct:  119 FEVGGYKWRLCLYPNGNKKSDGDGHISLYLVISDTQNLPLG-WEVTVSFKLFVFNHIHEEYLTVQDTDGKVRHFNVMKTQCGFAQFLPLDVLTDPCNGYLMD-DSCIFGAEVFVIKYS----------------------GKGECLSMIKEPDDGTFTWMIENFSRLKQEAIYSEIFTVKDFKWKLVVYPKGNYKAKNKSLSLFLELANRGTLHHQRKLYTEFELLVKEQCNGGHVKP--SHVKLNGQTWFCDSIK-----DWGFSNMISLSDLKDKSNHFILNDTLI 375          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKT------IHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVN 843
            W ++NF R+K  A++S+ F V  +  +L++YPKG+ +A    +S++L++ + RGT   +   +  + L +    +          ++  +W  F    K  G+ +    S + D    ++ N D++++ A I+++  S N
Sbjct:  253 WMIENFSRLKQEAIYSEIFTVKDFKWKLVVYPKGNYKAKNKSLSLFLELAN-RGTLHHQRKLYTEFELLVKEQCNGGHVKPSHVKLNGQTW--FCDSIKDWGFSNMISLSDLKDKSNHFILN-DTLIVEAKIMLMMHSKN 388          

Query: 1405 GKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPC-HLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKE 1827
            GK+ W+IE F+++     KR++     +S  F++G     +++YP+G     C HLS+FL V +       WS F    ++VVN+   +KS   ++ +R+ K   DWGW++F+ L+ + D   GF+  DT++  A+V +++E
Sbjct:   68 GKYTWKIEKFSQIN----KREL-----RSNAFEVGGYKWYILIYPQGCDV--CNHLSLFLCVANHDKLLPGWSHFAQFTIAVVNKD-PKKSKYSDTLHRFWKKEHDWGWKKFMELSKVLD---GFIDADTLIIKAQVQVIRE 194          

Query:  376 DGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNE 834
            D  GA+ S   +  G+Y+    W ++ F +I  R L S  FEVGGY   +LIYP+G    +  ++S++L + +        W  FA + +A+VN  D  K+ + D+ HRF  K+   GW  F   S V D       + D+++I A + ++ E
Sbjct:   57 DDTGAKPS---ELYGKYT----WKIEKFSQINKRELRSNAFEVGGYKWYILIYPQGCD--VCNHLSLFLCVAN-HDKLLPGWSHFAQFTIAVVN-KDPKKSKYSDTLHRFWKKEHDWGWKKFMELSKVLDG----FIDADTLIIKAQVQVIRE 194          

Query: 1486 KSRRFQIGNRDCRLIVYPRG--QSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQN---RYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFD------TICIYLESDQSVGCDLDKNFWVRYRMAVVNQKN 2136
            +S +F+ G    RL +YP G  +S    ++S++L + D +     W   V+ +L V N + ++    +++     R++      G+ +F++L  L D  +G+L++D+ +F AEV ++K       ++ +    S     +D      +FTW +ENF + KE    + ++S  F     + ++ +Y          ++ ++LE       D     +  + + + +Q N
Sbjct:   47 ESGKFEAGGYKWRLCLYPNGNIKSNGKGYISLYLAIADTKMLPLGWEVNVNFKLFVFNHKHDQYLTVQDAGGKLTRFNVMKTQCGFPQFLSLDVLNDPCNGYLMEDSCIFGAEVFVIK-------YSGKGECLSMIKEPVD-----GTFTWVIENFSTLKE----KVMYSDVFTVEDFKWKLILYPKGSSKTKNKSLSLFLELADCETLDNQSKLYAEFELLISDQGN 258          

Query:  496 FEVGGYDCRLLIYPKGDSQAL-PGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDS---WHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMI-----------KTQKIMSPSSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFA 1188
            FE GGY  RL +YP G+ ++   GYIS+YL I D +      W+   +++L + N   D     +D+     RF+  K   G+  F     + D   GYL   DS +  A++ ++  S                              + + + G FTW ++NFS  KE +           K + I+ P   +  +  S+ L  +  D   + +    +  F + + +Q       H  +Y  F+
Sbjct:   51 FEAGGYKWRLCLYPNGNIKSNGKGYISLYLAIADTKMLPLG-WEVNVNFKLFVFNHKHDQYLTVQDAGGKLTRFNVMKTQCGFPQFLSLDVLNDPCNGYLME-DSCIFGAEVFVIKYS----------------------GKGECLSMIKEPVDGTFTWVIENFSTLKEKVMYSDVFTVEDFKWKLILYPKGSSKTKNKSLSLFLELADCETLDNQSKLYAEFELLISDQGNLGYVKHHGTYYSFS 272          

Query: 1408 KFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILK 1824
            KF W I  FTRL        +         F +G    R++++P+G +    HLS++L+V DA N    WS +    L+VVNQ     S+ KE+Q++++    DWG+  F+ L+ L++   G+LV DTV+  AEV + K
Sbjct:   55 KFTWTIPMFTRLNTRKHYSDV---------FVVGGYKWRILIFPKGNNVD--HLSMYLDVADAANLPYGWSRYSQFSLAVVNQVNNRYSIRKETQHQFNARESDWGFTSFMPLSELYEPTRGYLVNDTVLIEAEVAVRK 182          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILI 825
            WT+  F R+  R  +S  F VGGY  R+LI+PKG++     ++S+YL + D        W  ++ + LA+VN  ++  +I +++ H+F++++   G+  F P S +++   GYL N D+VLI A++ +
Sbjct:   58 WTIPMFTRLNTRKHYSDVFVVGGYKWRILIFPKGNNV---DHLSMYLDVADAANLPYG-WSRYSQFSLAVVNQVNNRYSIRKETQHQFNARESDWGFTSFMPLSELYEPTRGYLVN-DTVLIEAEVAV 180          

Query: 1408 KFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILK 1824
            KF W I NF+R         +         F +G    R++++P+G +    HLS++L+V+DA +    WS +    L+VVNQ     +V KE+Q++++    DWG+  F+ L+ L+D   G+LV DTV+  AEV + K
Sbjct:   56 KFTWTIPNFSRQNTRKHYSDV---------FVVGGYKWRILIFPKGNNVD--HLSMYLDVSDAASLPYGWSRYAQFSLAVVNQIHTRYTVRKETQHQFNARESDWGFTSFMPLSELYDPSRGYLVNDTVLVEAEVAVRK 183          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILI 825
            WT+ NF R   R  +S  F VGGY  R+LI+PKG++     ++S+YL + D        W  +A + LA+VN      T+ +++ H+F++++   G+  F P S ++D   GYL N D+VL+ A++ +
Sbjct:   59 WTIPNFSRQNTRKHYSDVFVVGGYKWRILIFPKGNNV---DHLSMYLDVSDAASLPYG-WSRYAQFSLAVVNQIHTRYTVRKETQHQFNARESDWGFTSFMPLSELYDPSRGYLVN-DTVLVEAEVAV 181          

Query: 1843 EFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVY---ESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESS--ICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEI 2280
            E T  +T +S   +Q  ++     FTW + NF        TRK +S  F  GG + RI ++    + D + +YL+   +       + + ++ +AVVNQ +   TV KE+      +  +     FM +S++ +   G+LV DTV+   E+
Sbjct:   33 EVTQPETAASTVENQPAEDPPTLKFTWTIPNFSR----QNTRKHYSDVFVVGGYKWRILIFPKGNNVDHLSMYLDVSDAASLPYGWSRYAQFSLAVVNQIHTRYTVRKETQHQFNARESDWGFTSFMPLSELYDPSRGYLVNDTVLVEAEV 179          

Query: 4192 LASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEK-----NALAERLKNAEGARKRFDEELKRYATENVTREEI-RQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTC 4905
            L    +E +R VL     V +L    +  +  +    +++  ++RE++ AE      +K +  +K  E E    + +   K +      E++   + +Q+   + E  R ++  E +RLA +R+  Q+R    E QL   K R R E +++ +EK       L    +  E  R+  +E  KR   E + +E + R   E E +RL       E ++R+ +EQ A   A +  +   +Q    C
Sbjct:  547 LKLRREERLRKVLQARERVEQLEEEKKKKIEQKFAQIDEKSEKVREDRMAEEKA---KKKITAKKQEEVECRRRQEEEARKLKAKQMEEEERRHQDLLQKKREEEELERQKKIAEAKRLAEQRQAEQERERQREQQLLAEKERLRAERERIEREKALQLQRELERAAQEKEQQRREAEERKKREQQERLEQERLERLHKEQEAKRL------QEEQQRKAKEQAAAASAPVMNVTVDMQNSPAC 781          

Query: 4159 EVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEK---KAENATMVKEKAVILQKLSE-SEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAE----------RLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKE----------EQVARYEAYIYEMESKLQACQTCLINA 4917
            E+D DL   V    +E   ++   + + +  +LA  D   L   L A + +I+ +  EK   + +NA + K+ A + ++L E + A+N  L+ + K E      EK EL   ++E E     +R    +   ++ +ER  LQD+  D       LK ++ D  ++L + K+ALA+          +LKN E        EL       +  E+ ++SLE+E   L QT  Q E EK  KE          +Q+    + +  ++SKL A +  L  A
Sbjct:  857 EID-DLKKQVKDLEKELAALKDANAKLDKEKQLAEEDADKLEKDLAALKLKILDLEGEKADLEEDNALLQKKVAGLEEELQEETSASNDILEQKRKLEA-----EKGELKASLEEEER----NRKALQEAKTKVESERNELQDKYEDEAAAHDSLKKKEEDLSRELRETKDALADAENISETLRSKLKNTERGADDVRNELDDVTATKLQLEKTKKSLEEE---LAQTRAQLEEEKSGKEAASSKAKQLGQQLEDARSEVDSLKSKLSAAEKSLKTA 1120          

Query: 4105 RMLK-RLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDD---EIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKK---LVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQV 4845
            +MLK  + DL +S  D    V  +L+       ++ E ++  L  + +  + A   +  L   + A + +  R  + +  +N    +++  +L++L E E   T L+ E K      A  KK+L   ++++ESQ++     R++   ++R+L  + K  Q  L DA     ++ +  R+  KK   L  E   L E L  AE ARK+ D E +  A E  +    R SL+DE RRL   + Q E E  E+   +
Sbjct: 1513 KMLKAEMEDLVSSKDDVGKNVH-ELEKSKRTLEQQVEEMKTQLEELEDELQAAEDAKLRLEVNMQAMKSQFERDLQARDEQNE---EKRRQLLKQLHEHE---TELEDERKQRA-LAAAAKKKLEVDVKDLESQVDSANKAREEAIKQLRKLQAQMKDYQRDLDDARAAREEIFATARENEKKAKNLEAELIQLQEDLAAAERARKQADLEKEEMAEELASANSGRTSLQDEKRRLEARIAQLEEELDEEHSNI 1758          

Query: 4216 IRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENA---------TMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKR------------------------DELKKLVKEKNALAERL--------------KNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKL 4887
            ++P+L + R+  E+             A ++E+ R +E ++   A         T + E+  +LQ+  ++E        EM+  +   A +K+EL E + E+E+++E    E ++  ++L  E+K +Q ++ D E QL + ++ ++                        D+  KL KE+  L ER+              KN    + + +  +          E+ RQ LE   R+L       EGE  +  EQ+A  +A I E++++L
Sbjct:  847 VKPLLQVTRQEEEMQ------------AKDEELQRTKERQQKAEAELKELEQKHTQLCEEKNLLQEKLQAETELYAEAEEMRVRL---AAKKQELEEILHEMEARIE----EEEERSQQLQAEKKKMQQQMLDLEEQLEEEEAARQKLQLEKVTADGKIKKMEDDILIMEDQNNKLTKERKLLEERVSDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKIKRKL-------EGESSDLHEQIAELQAQIAELKAQL 1091          

Query: 3859 LERRLAQRLNLDAKFIGDNFQQTDVAAEGDAN------EQLRIQRDDFTSV-LGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSE-MKAEIDCFAREKKELSEQIQEVESQL-EWHR--SERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGE-KREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQ 4938
            L+++LAQ+L  D K   +  ++   + E  A+      E L++Q D+ +   L L   L  +         K  Y    + +ADE    R       +A   ++   +++  L+   +LA ++  +   V  ++ ++ E A      L  ++   E   + +  + K E  TM+ E+A    +   +E    + + E ++ + D  ARE K+L++ + E +SQL + HR   E++ EI+RL  ER+ L     +AET               L K++ A  +RL  AE A+ R D E KR A +    E +R+  + E+ +L   + + E + K E      +Y+A I E+E  L A     I+    + +Q
Sbjct:  228 LKQQLAQQLE-DTKHRLEEEERKRASLENHAHTLEVELESLKVQLDEESEARLELERQLTKANGDAASW--KSKYEAELQAHADEVEELRR-----KMAQKISEYEEQLEALLNKCSSLAKQKSRLQSEVEVLIMDL-EKATTHAQQLEKRVAQLEK--LNLDLKNKLEEVTMLMEQAQKEARAKAAELQKLQHEYEKLRDQRDALARENKKLTDDLAECKSQLNDAHRRIHEQEIEIKRLENEREELSAAYKEAET---------------LRKQEEAKNQRL-TAELAQVRHDYE-KRLAQKEEEIEALRKQYQIEIEQLNMRLAEAEAKLKTEIARLKKKYQAQITELELSLDAANKANIDLQKTIKKQ 571          

Query: 4192 LASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARK-RFDEELKRYATENVTREEIRQSLEDE--VRRLTQTVGQTEGEKREKEEQVARYE 4857
            L  EEQE+ +     +RE              QL   E++++R   ++K      ++E+  +LQ+  E        + +++ E D   RE+++L ++ +E        R  R +  R+L  E ++LQ+R  + E    Q + RK  E ++L++E+    ERL+  E  RK R +E+L R   + + +E  R+  E+E  +R+  Q + Q    K  +EEQ+ R E
Sbjct:  705 LRQEEQELRQERERKLREE------------EQLLRREEQLLRQERDRK------LREEEQLLQESEEERLRRQEREQQLRRERDRKFREEEQLLQEREE-------ERLRRQERERKLREEEQLLQER--EEERLRRQERERKLREEEQLLQERE--EERLRRQERERKLREEEQLLRQEEQELRQERARKLREEEQLLRQEEQELRQERDRKLREEEQLLRQE 900          

Query: 4327 EEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQ----IQEVESQL----EWHRSERD-DEIRRLATERKVLQDRLHDAETQLSQLK--------SRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIR---QSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQT 4902
            EE++AE   + + K    ++  E E    R + E+K E+    ++++E  EQ    +QE E QL     W    R+  ++RR   E +  + RL   E +  QL+         R+  +L++ ++E     +RL+  E   +R ++E +R        EEIR   Q LE E RR      +   + RE+ E + R   +  ++ES+  A Q+
Sbjct:  180 EERRAEEEQLRRRKGRDAEEFIEEEQLRRREQQELKRELREEEQQRRERREQHERALQEEEEQLLRQRRWREEPREQQQLRRELEEIREREQRLEQEERREQQLRREQRLEQEERREQQLRRELEEIREREQRLEQEERREQRLEQEERREQQLKRELEEIREREQRLEQEERREQLLAEEVREQARERGESLTR--RWQRQLESEAGARQS 389          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVN 843
            WT++ F  I  R L    FEVGGY   +LIYP+G    +  ++S++L +          W  FA + +A+ N  D  K+ H D+ HRF  K+   GW  F     +   K G++ ++  + I A + ++ E V+
Sbjct:   73 WTIEKFSDINKRELRGDVFEVGGYKWYILIYPQGCD--VCNHLSLFLCVAHHEKLLPG-WSHFAQFTIAVSN-KDPKKSKHSDTLHRFWKKEHDWGWKKFIELPKL---KEGFIDDSGCLTIKAQVQVIRERVD 199          

Query: 1405 GKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPC-HLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSL---FDQDSGFLVQDTVVFSAEVLILKE 1827
            GK  W IE F+ +     KR++ G       F++G     +++YP+G     C HLS+FL V         WS F    ++V N+   +KS   ++ +R+ K   DWGW++F+ L  L   F  DSG L        A+V +++E
Sbjct:   69 GKNTWTIEKFSDIN----KRELRGDV-----FEVGGYKWYILIYPQGCDV--CNHLSLFLCVAHHEKLLPGWSHFAQFTIAVSNKD-PKKSKHSDTLHRFWKKEHDWGWKKFIELPKLKEGFIDDSGCL-----TIKAQVQVIRE 196          

Query: 4090 ETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATE-RKVLQDRLHDAETQLSQLKSRKRDELKKLVKE-KNALAERLKNAEGARKRFDEELKRYATENVTRE--EIRQSLEDEV-RRLTQTVGQTEGEKREKE------EQVARYEAYIYEMESK 4884
            E YR +  K+L   A  T    HE +   DI       ++E    V   ++E+ E     +  +  ++   ++EI  ++EE K E    +KE   + +++ E +     +K E+K         K+E+ E+I+EV+ ++   + E  +EI+ +  E ++ +++ + + + ++ ++K   ++E+K+ +KE K  + E  +  +   K   EE+K    E +  E  EI++ L++++    T+    TE +K E E      ++V  Y+  + E E +
Sbjct:  457 EEYRKK--KKLESQANDTAMKMHEKEQIDDIQERKEEIKEEFKEEVKEEIKEIKEEIKEVKEEIKEEI---KEEIKEVKEEIKEEIKEEIKE---VKEEIKEVKEEIKEVKEEIK-------EVKEEIKEEIKEVKEEI---KEEIKEEIKEVKEEIKEEVKEEIKEVKEEIKEVKEEIKEEVKEEIKEVKEEIKEVKEEIKEEIKEVKEEIKEEVKEEIKEEIKEIKEELKNDISSETTKEEKNTEHKKEETEKKKFIPKRVIMYQQELKEKEER 714          

Query: 4306 DEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATE-NVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVAR--YEAYIYEMESKLQACQTCLIN-ASPYLMQQDIHTLYASLKEEMSRHAP----LYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVNGNV 5262
            D+I   +EE K E    VKE+      + E +     +K E+K EI      K+E+ E  +E++ +++    E  +EI+ +  E K +++ + + + ++ +     ++E+K+ +KE     E  +  E  ++   EE+K    E    +EEI++ +++E++ + + + + + E +E+ ++V     E    E++ +++  +  L N  S    +++ +T +   + E  +  P    +Y    + L  KE   L  + ++   +   LQ  + K   +SS  +    L+H   L      ++   + P    N    ++N + N N+
Sbjct:  483 DDIQERKEEIKEEFKEEVKEE------IKEIKEEIKEVKEEIKEEI------KEEIKEVKEEIKEEIKEEIKEVKEEIKEVKEEIKEVKEEIKEVKEEIKEEIKEVKEEIKEEIKE-----EIKEVKEEIKEEVKEEIKEVKEEIKEVKEEIKEEVKEEIKEVKEEIKEVKEEIKEEIKEVKEEIKEEVKEEIKEEIKEIKEELKNDISSETTKEEKNTEHKKEETEKKKFIPKRVIMY---QQELKEKEERNLKLLEQQRKEREMRLQLIRSKTQGTSSTFIPSAKLKHLESLKEEKKKEVKTNIQPK--DNNNNNNNNNNNNNNI 787          

Query: 4183 LVTLASEEQEIIR-----------PVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRK----RDELKKLVKEKNALAERLKNAEGARKR-------FDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCL----------------INASPYLMQQDIHTLYASLKEEMSR-----HAPLYGAGLEALSMKELET-LSGIHEEGLRQIHTLQQQQRKGS 5109
            L+ + SE+  II+           PV  + R++ E   +  A        ++ ++  + +E  AE A     +A + ++L   E   T +++ M+A      +E ++L  +I+ ++ QLE   +  + ++ RL  E  +L+D L+ A +Q+   ++ +    R EL K+ KE    +E ++  E  RK        F++++ +    +   EE  Q   DEV R       +    R   E+    +  + E+ SKLQ+ +  +                  A    + + I ++ A L+   +R      A    A  +   +KELE+ +SG+ +E +     ++QQ+ K +
Sbjct:  670 LIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKL-LATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLE---NGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNN 1018          

Query:  280 ATSSLNSGASEKLPSIPAAAP-----EDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGA-RKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSK-SPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVS-ENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVNGNVGPWFNHS 5283
            ++S++ S + +  P I   +P     +D S+A+  SRDG G QESVTVDRR ++S VC+WTV NFP+IKARALWSKYFEVGG+DCRLLIYPKGDSQALPGYIS+YLQIMDPRG+SSSKWDCFASYRLAIVN ADDSK+IHRDSWHRFSSKKKSHGWCDFTPS+T+FDSK GYLFN DSVLITADILILNESVNFTRD    NNELQ           VAGPVSDVLSGKFTWKV NFSLFKEMIKTQKIMSP               SSVNGVEYLSMCLESKDT+K VV SDRSCWCLFRMSVLNQKP  NHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDF+G++SGFL+DDTAVFSTSFHVIKEFSSFSKNGGLI  R GSG  RK DGH+GKF WRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTD+RNTSSDWSCFVSHRLSVVNQRME+KSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETS M + TDQD+ESSN+GSQIDK GKRSSFTW+VENF+SFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVG D DKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEV ASEDDQDALTTDPDEL+               FRNLLSRAGFHLTYGDNP+QPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGS+DG KV K DESSPSLMNLLMGVKVLQQA        MVECCQP+EG S  D SD NSK SP GSGA  PL+ DRENGATES++ P  ERL                  + G  VP K +PG+PI PPETSAG S EN +LRSKTKWPEQSEELLGLIVNSLRALDGAV            SAQKIALVLDKAPKHLQ DLVALVPKLVEHSEHPLAA AL++RLQKPDAEPALR PVFGALSQL+CGSEVWER+L QSFE L DSNDEPL ATI+FIFKAASQCQHLPEAVRS+RV+LK+LG ++SPCVL+FL++TVNSWGDVAETILRDIDCDD+FGD CST+  GLFLFGE+GP SER H +DEQAF ++R FSDIY+LIEMLSIPCLAVEASQTFERAVARGA VA SVAMVLE RLAQRLN +++F+ ++FQ TDV  EG+ NEQLR QRDDF+SVLGLAETLALSRDP VKGFVK+LYT+LFKWYADE+YRGRMLKRLVD ATSTTDS+ E+DL+L+ILV L  EEQEI+RPVLSMMREVAELANVDRAALWHQLC SEDEIIRMREE+KAE + +VKEKA+I Q+LSESEAT+ RLKSEM+AE D FAREKKELSEQIQEVESQLEW RSERD+EI +L +E+KVLQDRLHDAE QLSQLKSRKRDELK++VKEKNALAERLK+AE ARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVAR EAYI  MESKLQAC            QQ IHTL ASL+EEMSRHAPLYGAGLEALSMKELETL+ IHEEGLRQIH +  QQ KGSP+ SPLVSPH LQH+HGLYP  PP MAVG+PPSLIPNGVGIHSNGHVNG VG WFNH+
Sbjct:   18 SSSTVPSSSEQSQPPIATPSPSPSMGDDPSLAA--SRDGHG-QESVTVDRRTDFSAVCKWTVHNFPKIKARALWSKYFEVGGFDCRLLIYPKGDSQALPGYISVYLQIMDPRGSSSSKWDCFASYRLAIVNHADDSKSIHRDSWHRFSSKKKSHGWCDFTPSTTLFDSKSGYLFNNDSVLITADILILNESVNFTRD----NNELQSASSMASMV--VAGPVSDVLSGKFTWKVHNFSLFKEMIKTQKIMSPVFPAGECNLRISVYQSSVNGVEYLSMCLESKDTEKAVV-SDRSCWCLFRMSVLNQKPGLNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFIGSDSGFLVDDTAVFSTSFHVIKEFSSFSKNGGLIGVRGGSGGTRKSDGHLGKFTWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDSRNTSSDWSCFVSHRLSVVNQRMEDKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSTMLDLTDQDSESSNSGSQIDKIGKRSSFTWRVENFMSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGSDPDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVLASEDDQDALTTDPDELIDSEDSEGISGDEEDIFRNLLSRAGFHLTYGDNPAQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSNDGKKVTKTDESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPSEGNSNDDSSDENSKLSPGGSGAVSPLESDRENGATESAEFPVYERLDSGVYESTNVSAVQSSD-MNGTVVPEKAVPGQPISPPETSAGGSIENASLRSKTKWPEQSEELLGLIVNSLRALDGAVPQGCPEPRRRPQSAQKIALVLDKAPKHLQPDLVALVPKLVEHSEHPLAACALLDRLQKPDAEPALRIPVFGALSQLECGSEVWERILFQSFELLSDSNDEPLAATINFIFKAASQCQHLPEAVRSIRVKLKHLGAEVSPCVLDFLNKTVNSWGDVAETILRDIDCDDDFGDNCSTIPCGLFLFGENGPTSERLHAIDEQAFCATRHFSDIYLLIEMLSIPCLAVEASQTFERAVARGAFVAQSVAMVLESRLAQRLNFNSRFVAESFQHTDVVVEGETNEQLRAQRDDFSSVLGLAETLALSRDPRVKGFVKVLYTILFKWYADESYRGRMLKRLVDRATSTTDSSREIDLELEILVILVCEEQEIVRPVLSMMREVAELANVDRAALWHQLCTSEDEIIRMREERKAEISNLVKEKAIISQRLSESEATSNRLKSEMRAEADRFAREKKELSEQIQEVESQLEWLRSERDEEITKLTSEKKVLQDRLHDAEAQLSQLKSRKRDELKRVVKEKNALAERLKSAEAARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARCEAYIDGMESKLQAC------------QQYIHTLEASLQEEMSRHAPLYGAGLEALSMKELETLARIHEEGLRQIHAI--QQHKGSPAGSPLVSPHTLQHSHGLYPPAPPPMAVGLPPSLIPNGVGIHSNGHVNGAVGSWFNHN 1683          

Query:  271 SQPATSSLNSGAS----EKLPSIPAAAPEDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSK-SPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVN--GNVGPWFNHS 5283
            S  A  SL+S  S        S  AAA EDL+V S     GGGAQE+V VDRRGEYS +CRWTV NFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPS+TVFD KLGYLFNTDSVLITADILILNESVNFTRD NN                 VAGPVSDV SGKFTWKV NFSLFKEMIKTQKIMSP               SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKP +NHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDF+G +SGFL+DDTAVFSTSFHVIKEFSSFSKNG +I GRS SGARK DGH+GKF WRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTD+RNTSSDWSCFVSHRLSVVNQRME+KSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTV+FSAEVLILKETS MQ+ T+ D+E S++GSQ+D NGKRSSF+WKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQ+VG D DKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLE+DAGFLVRDTVVFVCEILDCCPWFEFSDLEV ASEDDQDALTTDPDEL+               FRNLL RAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGS DG K  K DESSPSLMNLLMGVKVLQQA        MVECCQP+E     D  DA SK SP+GSGAA P + +RENGA ES+  P CERL                  + G G+  K LPG+PICPPETSA  SEN +LRSKTKWPEQSEELLGLIVNSLRALDGAV            SAQKI+LVLDKAPKHLQ+DLVALVPKLVE SEHPLAA+AL+ERLQKPDAEPALR PV+GALSQL+CGSEVWER+L QSFE L DSNDEPL ATIDFIFKAASQCQHLPEAVRSVRVRLKNLG+++SPCVL+FLS+T+NSWGDVAETILRDIDCDD++GD+CS L  G+FLFGEH       H +DEQA+ +SR FSDIYIL EMLSIPCL  EASQTFERAVARG I A SVA+VL+ RL+QRLN +  ++ +N Q +D A EGDA EQL +QRDD+TSVLGLAE LALSRDPCVK FVK+LY ++F+W+A+E+YRGRMLKRLVD ATS TD+  EVD DLDILVTL  EEQE IRPVLSMMREVAELANVDRAALWHQLCASEDEI+R+REE K E + M KEK++I QKL+ESEAT+ RLKSEM+AE+D F+REKKEL+EQIQEVESQLEW RSERDDEI +L+ E+K L DRLHDAETQLSQLKSRKRDELKK+VKEKNALAERLKNAE ARKRFDEELKR+ATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVAR EAYI  MESKLQAC            QQ IHTL ASL+EEMSRHAPLYGAGLEALS+KELETLS IHE+GLRQIH L  QQRKGSP+ SPLVSPHAL H+HGLYP+  P MAVG+PPS+IPNGVGIHSNGHVN  G VGPWFNHS
Sbjct:    5 SSEAVPSLSSAPSFTETATSSSWSAAAAEDLTVGSRDG--GGGAQETVAVDRRGEYSALCRWTVHNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSNTVFDPKLGYLFNTDSVLITADILILNESVNFTRD-NNEVQSSSSSSSNAMTSSVVAGPVSDVSSGKFTWKVHNFSLFKEMIKTQKIMSPVFPAGECNLRISVYQSSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPGSNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFIGADSGFLVDDTAVFSTSFHVIKEFSSFSKNGAVIAGRSASGARKSDGHIGKFTWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDSRNTSSDWSCFVSHRLSVVNQRMEDKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVIFSAEVLILKETSTMQDITENDSELSSSGSQVDGNGKRSSFSWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQAVGSDPDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLESDAGFLVRDTVVFVCEILDCCPWFEFSDLEVLASEDDQDALTTDPDELIDSEDSEGISGDEEDIFRNLLFRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSCDGKKASKADESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPSEVGPVADSVDACSKPSPNGSGAASPFECERENGAMESARVPVCERL-DSVVQESSNASAVQSSDLKGNGLQEKALPGQPICPPETSATASENASLRSKTKWPEQSEELLGLIVNSLRALDGAVPQGCPEPRRRPQSAQKISLVLDKAPKHLQADLVALVPKLVEQSEHPLAAYALLERLQKPDAEPALRIPVYGALSQLECGSEVWERILFQSFELLTDSNDEPLTATIDFIFKAASQCQHLPEAVRSVRVRLKNLGLEVSPCVLDFLSKTINSWGDVAETILRDIDCDDDYGDSCSALPCGIFLFGEHDTAPSGLHVIDEQAYHASRHFSDIYILFEMLSIPCLVAEASQTFERAVARGVISAQSVALVLQSRLSQRLNNNGSYVSENCQHSDDATEGDACEQLGVQRDDYTSVLGLAENLALSRDPCVKEFVKLLYMIMFRWFANESYRGRMLKRLVDCATSNTDNGREVDFDLDILVTLVCEEQEFIRPVLSMMREVAELANVDRAALWHQLCASEDEIMRVREESKTEISNMAKEKSMISQKLTESEATSNRLKSEMRAEMDRFSREKKELAEQIQEVESQLEWIRSERDDEIAKLSAEKKALHDRLHDAETQLSQLKSRKRDELKKVVKEKNALAERLKNAEAARKRFDEELKRFATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARCEAYIDGMESKLQAC------------QQYIHTLEASLQEEMSRHAPLYGAGLEALSLKELETLSRIHEDGLRQIHAL--QQRKGSPAGSPLVSPHALPHSHGLYPTASPPMAVGLPPSIIPNGVGIHSNGHVNGGGGVGPWFNHS 1679          

Query:  265 DHSQPATSSLNSGASEKLPSIPAAAPEDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNEL--QXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIG-------------------------------------VYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTE-GTSYGDLSDANSKSPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVNGNVGPWFNH 5280
            D SQPATSS +S +        AAA EDL++ S   RDGG A E+V VDRR EYS VC+WTV NFP++KARALWSKYFEVGGYDCRLLIYPKGDSQALPGYIS+YL+IMDPRGTSSSKWDCFASYRLA VN+ DDSKTIHRDSWHRFS+KK+SHGWCDFTP+ST+FD KLGYLFN DSVLITADILILNESVNFTR+    NNEL              VAGPVSDVLSGKFTWKV NFSLFKEMI+TQKIMSP               S+V+GVEYLSMCLESKDTDK  +LSDRSCWCLFRMSVLNQKP +NHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGT+SGF++DDTAVFSTSFHVIKEFSSFSKNG +I GRSG  ARK DGH+GKF WRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTD+RN+SSDWSCFVSHRLSVVNQ+ E+KSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTV+FSAEVLILKETSIMQ+FT+ D+ES+++ S +D  GKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIG                                     VYESFDTICIYLESDQ+VG D DKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFL+RDTVVFVCEILDCCPWF+FSDLEVFASEDDQDALTTDPDEL+               FRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGS DG K  K DESSPSLMN+LMGVKVLQQA        MVECCQP+E G     + + +  SPD SG A PL  D EN A ES+     ERL                  + G  +  K LPG+PICPPET A VSEN + RSKTKWP+QSEELLGLIVNSLRALDGAV            SAQKIALVLDKAPKHLQ+DLV LVPKLVE SEHPLAA+ALIERLQ+PDAEPALR PVFGALSQL+CGSEVWER+L QSFE L DSNDEPLVATIDFIFKAASQCQHLPEAVR+VRVRLK+LG+D+SPCVL+FLS+T+NSWGDVAETILRDIDCD+++G++C+ L  G+FLFGEHG  +   H +DEQAFR+SR FSDIYIL+EMLSIPCLAVEASQTFERAVARGAI A SVA+VLE   +QRLN +A+   +NFQ  D A E DA EQ  +QRDDFTSVLGLAETLALSRD CVK FVK+LY ++F+WYA+E+YRGRMLKRLVD ATSTTD+  EVD DLDILVTL  EEQE IRPVLSMMR VAELANVDRAALWHQLCASEDEII +REE K + + M  EKAV+ QKLSESEATN RLKSEMKAE+D F+REKKEL+E IQE+ESQLEWHRSERDDEI +L++E+KVL DRLHDAE QLSQLKSRKRDELKK+VKEKNALAERLKNAE ARKRFDEELKR+ATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVAR EAYI  MESKLQAC            QQ IHTL ASL+EEMSRHAPLYGAGLEALSMKELET+S IHEEGLRQIH L  QQRKGSP+ SPL+SPHAL H+HGLYP+     +VG+PPS+IPNGVGIHSNGHVNG VGPWFNH
Sbjct:   23 DQSQPATSSSSSSS--------AAAAEDLAIGS---RDGGSALETVVVDRRNEYSAVCKWTVNNFPKVKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISVYLKIMDPRGTSSSKWDCFASYRLAFVNVVDDSKTIHRDSWHRFSTKKQSHGWCDFTPASTIFDPKLGYLFNNDSVLITADILILNESVNFTRE----NNELLSSSLSSSTLSSSVVAGPVSDVLSGKFTWKVHNFSLFKEMIRTQKIMSPIFPAGECNLRISVYQSTVSGVEYLSMCLESKDTDKNAMLSDRSCWCLFRMSVLNQKPGSNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTDSGFVVDDTAVFSTSFHVIKEFSSFSKNGAVIGGRSGGSARKSDGHIGKFTWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDSRNSSSDWSCFVSHRLSVVNQKTEDKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVIFSAEVLILKETSIMQDFTEHDSESNSSSSLLDSTGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGMCFMAHILSPAFYPLAVVIANLNYYSLIKSLCFNPPGVYESFDTICIYLESDQAVGSDPDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLLRDTVVFVCEILDCCPWFDFSDLEVFASEDDQDALTTDPDELIDSEGSEGISGDEEDIFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSCDGKKATKADESSPSLMNMLMGVKVLQQAIIDLLLDIMVECCQPSEVGPVSDSVEECSKPSPDSSGTASPLHCDNENRAVESAQVLVHERLDSVVEESCSTSSVQSSD-LNGHCIQEKALPGQPICPPETCATVSENTSFRSKTKWPDQSEELLGLIVNSLRALDGAVPQGCPEPRRRPQSAQKIALVLDKAPKHLQADLVTLVPKLVEQSEHPLAAYALIERLQQPDAEPALRIPVFGALSQLECGSEVWERILFQSFELLTDSNDEPLVATIDFIFKAASQCQHLPEAVRTVRVRLKSLGLDVSPCVLDFLSKTINSWGDVAETILRDIDCDEDYGESCTALPCGIFLFGEHGAAATGLHMIDEQAFRASRHFSDIYILLEMLSIPCLAVEASQTFERAVARGAIGAQSVALVLESLFSQRLNNNART--ENFQHPDGATEEDACEQFGVQRDDFTSVLGLAETLALSRDLCVKEFVKLLYMIIFRWYANESYRGRMLKRLVDRATSTTDNGREVDFDLDILVTLVCEEQEYIRPVLSMMRGVAELANVDRAALWHQLCASEDEIIHIREENKTDISNMASEKAVLSQKLSESEATNNRLKSEMKAEVDQFSREKKELAEHIQEIESQLEWHRSERDDEILKLSSEKKVLHDRLHDAEAQLSQLKSRKRDELKKVVKEKNALAERLKNAEAARKRFDEELKRFATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARCEAYIDGMESKLQAC------------QQYIHTLEASLQEEMSRHAPLYGAGLEALSMKELETISRIHEEGLRQIHAL--QQRKGSPAGSPLLSPHALPHSHGLYPAG----SVGLPPSVIPNGVGIHSNGHVNGAVGPWFNH 1713          

Query:  265 DHSQPATSSLNSGASEKLPSIPAAAPEDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRD--SNNNNNELQXXXXXXXXXXXVA-GPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPX-TNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSK-SPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAG-VSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVNGNVG 5265
            D S  ATSS  + A+   P+      +D++V +T     G A E+VT+DRRGEYS +C+WTVQNFPR+KARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRL+I N  DDSKTIHRDSWHRFSSKKKSHGWCDFTP+STVFDSKLGYLFN D VLITADILILNESV+F RD  S+ +NNE+Q           V  GPVSDVLSGKFTWKV NFSLFKEMIKTQKIMS                SSVNG +YLSMCLESKDT+KT V SDRSCWCLFRMSVLNQK   +NH+HRDSYGRFAADNKSGDNTSLGWNDYMKM+DFVG ESGFL+DDTAVFSTSFHVIKEFSSFSKNGGL  GR G GARK DGHMGKF WRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPR          VFLEVTD+RNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQ+F DQDTES+N+ SQID  GKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVG D DKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLE DAGFLVRDTVVFVCEILDCCPWFEFSDLEV ASEDDQDALTTDPDEL+               FRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGS+D  K  K DESSPSLMNLLMGVKVLQQA        MVECCQP+EG+S  D SDA+ K S DGSGAA PL+ DRE+GATES+  P  ERL                  + G G+P + LPG+PI PP T+AG  S N +LRSKTKWPEQSEELLGLIVNSLRALDGAV            SAQKIALVLDKAPKHLQ DLV+LVPKLVEH+EHPL A+AL+ERLQKPDAEPALR PVFGALSQL+CGS+VWERVL QSF+ L DSNDEPL ATIDFIFKAASQCQHLPEAVRSVR RLK LG D+SP VL+FLS+TVNSWGDVAETILRDIDCDD+ GD+CSTL  GLFLFGE+   +ER   VDEQ F SS  FSDIYILIEMLSIPCLA+EASQTFERAV RGAI+A SVA+VLERRLAQRLN +A+F+ +NFQQ D   EG+A+EQLR+QRDDF+ VLGLAETLALSRD CVKGFVKMLY +LFKWYA+E  RGRMLKRLVD ATSTTD++ +VDLDLDIL  L  EEQEI++PVLSMMREVAELANVDRAALWHQLCASEDEIIRMR+E+KAE + M +EKA + QKLS+SEATN RLKSEM+AE+D FAREKKELSEQI EVESQLEW RSERDDEI +L  E+KVLQDRLHDAETQLSQLKSRKRDELK++VKEKNAL ERLK+AE ARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVAR EAYI  MESKLQAC            QQ IHTL ASL+EEM+RHAPLYGAGLEALSM+ELET+S IHEEGLRQIH L  QQRKGSP +SP VSPH L HNHG+YP+ PP MAVG+PP LI NGVGIHSNGH+NG VG
Sbjct:   21 DQSSLATSSSTTTAT---PTSTTTTIDDITVGTTRDGTNGAAAEAVTIDRRGEYSAICKWTVQNFPRVKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLSIFNPLDDSKTIHRDSWHRFSSKKKSHGWCDFTPASTVFDSKLGYLFNNDCVLITADILILNESVSFIRDNSSSTSNNEVQSGVSLSISSNSVVVGPVSDVLSGKFTWKVHNFSLFKEMIKTQKIMSQVFPAGECNLRISVYQSSVNGTDYLSMCLESKDTEKTSV-SDRSCWCLFRMSVLNQKAGGSNHVHRDSYGRFAADNKSGDNTSLGWNDYMKMADFVGAESGFLVDDTAVFSTSFHVIKEFSSFSKNGGLNGGRIGGGARKSDGHMGKFTWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPR----------VFLEVTDSRNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQDFIDQDTESTNSASQIDGVGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGSDPDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLETDAGFLVRDTVVFVCEILDCCPWFEFSDLEVLASEDDQDALTTDPDELIDSDDSEGISGDEEDIFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSNDAKKATKADESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPSEGSSNDDSSDAHPKPSLDGSGAASPLESDRESGATESARFPVHERLDSGLDDSTRASAVQSSD-INGTGIPGQALPGQPIHPPVTTAGGASGNASLRSKTKWPEQSEELLGLIVNSLRALDGAVPQGCPEPRRRPQSAQKIALVLDKAPKHLQPDLVSLVPKLVEHAEHPLVAYALLERLQKPDAEPALRIPVFGALSQLECGSDVWERVLFQSFDLLADSNDEPLAATIDFIFKAASQCQHLPEAVRSVRSRLKILGADVSPFVLDFLSKTVNSWGDVAETILRDIDCDDDLGDSCSTLPCGLFLFGENASAAERLQVVDEQTFHSSSHFSDIYILIEMLSIPCLALEASQTFERAVGRGAIMAQSVAIVLERRLAQRLNFNARFVAENFQQEDAILEGEASEQLRVQRDDFSVVLGLAETLALSRDLCVKGFVKMLYMILFKWYANEPCRGRMLKRLVDHATSTTDNSRDVDLDLDILAILVCEEQEIVKPVLSMMREVAELANVDRAALWHQLCASEDEIIRMRDERKAEISNMAREKANLSQKLSDSEATNNRLKSEMRAEMDRFAREKKELSEQIHEVESQLEWVRSERDDEIIKLTVEKKVLQDRLHDAETQLSQLKSRKRDELKRVVKEKNALTERLKSAEAARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARCEAYIDGMESKLQAC------------QQYIHTLEASLQEEMTRHAPLYGAGLEALSMQELETISRIHEEGLRQIHVL--QQRKGSP-ASPHVSPHTLPHNHGMYPAAPPPMAVGLPP-LISNGVGIHSNGHINGAVG 1677          

Query:  343 EDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRD---SNNNNNELQXXXXXXXXXXXVA-GPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPX-TNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSK-SPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVS-ENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELK----------------------KLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVNGNVGPWFNHS 5283
            +D++V +T     G A E+VT+DRRGEYS  C+WTVQ+FPR+KARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRL+IVN  DDSKTIHRDSWHRFSSKKKSHGWCDFTP+STVFDSKLGYLFN D VLITADILILNESV+F RD   S+ +NNE+Q           VA GPVSDVLSGK TWKV NFSLFKEMIKTQKIMSP               SSVNG +YLSMCLESKDT+KTVV SDRSCWCLFRMSVLNQK   +NH+HRDSYGRFAADNKSGDNTSLGWNDYMKM+DF+G ESGFL+DDTAVFSTSFHVIKEFSSFSKNGGLI GR GSGARK DGHMGKF WRIENF RLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPR          VFLEVTD RNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQ+FTDQDTES+N  SQIDK GKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVG D DKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLE DAGFLV                         ASEDDQDALTTDPDEL+               FRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLD+PAKVK+LLLPTKLSG +DG K  K DESSPSLMNLLMGVKVLQQA        MVECCQP EG+S  D SDA+SK S DGSGAA PL+ DR +GATES+  P  ERL                  + G  +P + LPG+PI PP T+AG + EN +LRSKTKWPEQSEELLGLIVNSLRALDGAV            SAQKIALVLDKAPKHLQ DLV+L+PKLVEH+EHPLAA+AL+ERL+KPDAEPAL  PVFGALSQL+CGS+VWERVL QSF+ L DSNDEPL ATIDFIFKAASQCQHLPEAVRSVR RLKNLG D+SP VL+FLSRTVNSWGDVAETILRDIDCDD  GD+CSTL  GLFLFGE+   +ER H VDEQ F     FSDIYILIEMLSIPCLAVEASQTFERAVARGAI+A SVAMVLERRLAQRLN +A+F+ +NFQ TD   E +A+EQLR+QRDDF+ VLGLAETLALSRD CVKGFVKMLYT+LFKWYA+ETYRGRMLKRLVD ATSTTD++ +VDLDLDIL  L  EEQEI++PVLSMMREVAELANVDRAALWHQLCASEDEIIR+R+E+KAEN+ M +EKA + QKLS+ EATN RLKSEMKAE+D F REKKELSEQIQEVESQLEW RSERDDEI +L  E+KVLQDRLHDAETQLSQLKSRKRDELK                      K+VKEKNALAERLK+AE ARKRFDEELKRYATENVTREEIRQSLEDEVRRLT+TVGQTEGEKREKEEQVAR EAYI  MESKLQAC            QQ IHTL AS+++EM+RHAPLYGAGLEALSM+ELET+S IHEEGLRQIH L  QQ KGSP+SSP VSPH L HNHGLYP+ PP MAVG+PP LIPNGVGIH+NG VNG VGPWFNH+
Sbjct:   10 DDITVGTTLDGTNGAAAETVTIDRRGEYSATCKWTVQSFPRVKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLSIVNPLDDSKTIHRDSWHRFSSKKKSHGWCDFTPASTVFDSKLGYLFNNDCVLITADILILNESVSFMRDNSSSSTSNNEVQSGVSLSISSNSVAVGPVSDVLSGKCTWKVHNFSLFKEMIKTQKIMSPVFPAGECNLRISVYQSSVNGTDYLSMCLESKDTEKTVV-SDRSCWCLFRMSVLNQKAGGSNHVHRDSYGRFAADNKSGDNTSLGWNDYMKMADFIGAESGFLVDDTAVFSTSFHVIKEFSSFSKNGGLIGGRIGSGARKSDGHMGKFTWRIENFMRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPR----------VFLEVTDLRNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQDFTDQDTESTNGTSQIDKVGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGSDPDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLETDAGFLV------------------------LASEDDQDALTTDPDELIDSEDSEGNSGDEEDIFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDEPAKVKKLLLPTKLSGGNDGKKAAKADESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPLEGSSNDDSSDAHSKPSLDGSGAASPLESDRGSGATESAQFPVHERLDSGLDDSKRASAVQSSD-INGTDMPGQALPGQPIYPPVTTAGGALENASLRSKTKWPEQSEELLGLIVNSLRALDGAVPQGCPEPRRRPQSAQKIALVLDKAPKHLQPDLVSLIPKLVEHAEHPLAAYALLERLKKPDAEPALWIPVFGALSQLECGSDVWERVLIQSFDLLADSNDEPLAATIDFIFKAASQCQHLPEAVRSVRTRLKNLGADVSPFVLDFLSRTVNSWGDVAETILRDIDCDDALGDSCSTLPCGLFLFGENASAAERLHVVDEQTFHFRCHFSDIYILIEMLSIPCLAVEASQTFERAVARGAIMAQSVAMVLERRLAQRLNFNARFVNENFQHTDAIIEEEASEQLRVQRDDFSVVLGLAETLALSRDLCVKGFVKMLYTILFKWYANETYRGRMLKRLVDRATSTTDNSCDVDLDLDILAILVCEEQEIVKPVLSMMREVAELANVDRAALWHQLCASEDEIIRIRDERKAENSNMAREKANLSQKLSDCEATNNRLKSEMKAEMDRFTREKKELSEQIQEVESQLEWLRSERDDEITKLTVEKKVLQDRLHDAETQLSQLKSRKRDELKMQLFYCATSDHVAFLWRNVLEIKVVKEKNALAERLKSAEAARKRFDEELKRYATENVTREEIRQSLEDEVRRLTKTVGQTEGEKREKEEQVARCEAYIDGMESKLQAC------------QQYIHTLEASVQDEMTRHAPLYGAGLEALSMQELETISRIHEEGLRQIHAL--QQCKGSPASSPHVSPHTLPHNHGLYPAAPPPMAVGLPP-LIPNGVGIHNNGLVNGTVGPWFNHT 1649          

Query:  271 SQPATSSLNSGASEKLPSIPAAAPEDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSK-SPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSE-HPLAAFALIERLQKPDAEPALRTP--VFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVNGN-VGPWFNHS 5283
            ++ ATSS +S          AAA EDL+V S     GGGAQE+V VDRRGEYS VCRWTV NFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPS+TVFD KLGYLFNTDSVLITADILILNESVNFTRD NN                 VA PVSDV SGKFTWKV NFSLFKEMIKTQKIMSP               SSVNGVEYLSMCLESKDTDK+VVLSDRSCWCLFRMSVLNQKP +NHMHRDSYGRFAADNKSGDNTSLGWNDYMKM DF+  +SGFL+DDTAVFSTSFHVIKEFSSFSKNG +I GRSGSGARK DGH+GKF WRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTD+RNTSSDWSCFVSHRLSVVNQRME+KSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTV+FSAEVLILKETSIMQ+ T+ D+E S++GS +D   KRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQ+VG D DKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEV ASEDDQDALTTDPDEL+               FRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGS DG K  K DESSPSLMNLLMGVKVLQQA        MVECCQP+E     D  DA SK SP+GSGAA PL+ +RENGA ES+  P CERL                  + G G+  K LPG+PICPPETSA  SEN +LRSKTKWPEQSEELLGLIVNSLRALDGA                     +      + + +   + +L   SE      F   E L   + EP   T   +F A SQ     E    V  +    L++   E     +DF+ K  +    + E +      L+++  D             +  GD    +   I    E G    T  SGL +  E             QA+ +SR FSDIYIL EMLSIPCL  EASQTFERAVARGAI A SV +VL+ RL+QRLN +  +  +NFQ +D A EGDA EQL +QRDD+TSVLGLAE LALS+DPCVK FVK+LY ++F+W+A+E++RGRMLKRLVD ATS TD+  EVD DLDILVTL  EEQE IRPVLSMMREVAELANVDRAALWHQLCASEDEI+R+REE K E + M KEK +I QKLSESEATN RLKSEM+ E+D F+REKKEL+EQIQEVESQLEW RSERDDEI +L+ E+K L DRLHDAETQLSQLKSRKRDELKK+VKEKNALAERLKNAE ARKRFDEELKR+ATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVAR EAYI  MESKLQAC            QQ IHTL ASL+EEMSRHAPLYGAGLEALS+KELETLS IHE+GLRQIH L  QQRKGSP+ SPLVSPHAL H HGLYP+  P MAVG+PPS+IPNGVGIHSNGHVNG  VGPWFNHS
Sbjct:   19 TEAATSSTSS----------AAAAEDLAVGSRDG--GGGAQETVAVDRRGEYSAVCRWTVHNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSNTVFDPKLGYLFNTDSVLITADILILNESVNFTRD-NNEVQSSSSSSSSAMTSSVVASPVSDVSSGKFTWKVHNFSLFKEMIKTQKIMSPVFPAGECNLRISVYQSSVNGVEYLSMCLESKDTDKSVVLSDRSCWCLFRMSVLNQKPGSNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMLDFIDADSGFLVDDTAVFSTSFHVIKEFSSFSKNGAVIAGRSGSGARKSDGHVGKFTWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDSRNTSSDWSCFVSHRLSVVNQRMEDKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVIFSAEVLILKETSIMQDITENDSELSSSGSPVD---KRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQAVGSDPDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVLASEDDQDALTTDPDELIDSEDSEGISGDEEDIFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSCDGKKATKADESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPSEVGPVADSVDACSKPSPNGSGAASPLECERENGAMESARVPVCERL-DSVVQESSNASAVQSSDLKGNGIQEKALPGQPICPPETSATASENASLRSKTKWPEQSEELLGLIVNSLRALDGAT----------------YLFCISTITNMMLNIVYGALSQLECGSEVWERILFQSFELLTDSNDEPLTATINFIFKAASQCQHLPEAVRSVRVR----LKNLGLEVSPCVLDFLSKTINSWGDVAETI------LRDIDCD-------------DDCGDSCSALPCGIFLFGEHG----TAPSGLHVIDE-------------QAYHASRHFSDIYILFEMLSIPCLVAEASQTFERAVARGAISAQSVTLVLQSRLSQRLNNNGSYASENFQHSDGATEGDACEQLGVQRDDYTSVLGLAENLALSKDPCVKEFVKLLYMIMFRWFANESHRGRMLKRLVDRATSNTDNGREVDFDLDILVTLVCEEQEFIRPVLSMMREVAELANVDRAALWHQLCASEDEIVRVREESKNEISNMAKEKVMISQKLSESEATNNRLKSEMRTEMDRFSREKKELAEQIQEVESQLEWIRSERDDEIAKLSAEKKALHDRLHDAETQLSQLKSRKRDELKKVVKEKNALAERLKNAEAARKRFDEELKRFATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARCEAYIDGMESKLQAC------------QQYIHTLEASLQEEMSRHAPLYGAGLEALSLKELETLSRIHEDGLRQIHAL--QQRKGSPAGSPLVSPHALPHTHGLYPTAAPPMAVGLPPSIIPNGVGIHSNGHVNGGAVGPWFNHS 1622          

Query:  265 DHSQPATSSLNSGASEKLPSIPAAAPEDLSVASTPSRDG-GGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSKSPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQ---MAVGMPPSLIPNGVGIHSNGHVNGNVGPWFNH 5280
            D S P+ SS  S + + L S   +  EDL V S  SRDG GGAQE V VDR GEYS +CRWTV++F R+KA+ALWSKYF+VGGYDCRLL+YP+GDSQALPGYISIYLQIMDPRGT+SS+WDCFASYRL+IVNL DDS TIH+DSWHRFSSKKKSHGWCDFT +S++ D K+G+LFN DS+LITADILILNESV+F+RD+NN    L            +AGP+ DVLSGKFTWKV NFSLFK+MIKTQKIMSP               S VN  EY+SMCLESK+T+KT+V SDRSCWCLFRMS LNQKP   HMHRDSYGRFAADNKSGDNTSLGWNDYMKMS+FV  E+GFLLDD AVFSTSFHVIKEFSSF+KNGGLI GR+G+GARK DGHMGKF WRIENFTRLKDLLKKRKITGLCIKS+RFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTD+R+ SSDWSCFVSHRLSVVNQR+EEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETS  +E+ + D  S+N+ S  D + K+SSFTWKVENFL+FKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQS G D+D NFWV+Y+M ++NQKNPAK+VWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEV AS+DDQDALTTDPDE++               FR+ LSRAGFHLT+G+NPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDP KVKRLLLPTK+S  +D  K+IK+DESSPSLMNLLMGVKVLQQA        MVECCQP+E  S+ + S  + K+ DG  AA   +  RE GA E S     ER                   + GI +  K L  +P+ PP TSAG S + +++SKTKWPEQSEELLGLIVNSL+ LD AV            SAQKIALVLD+APKHLQ DLV+LVPKLVEHSEHPLAA ALIERLQKP+AEPALR PV+ ALSQL+C SEVWE +LSQSFE L D N+E LVA I F FK ASQCQHLPEAV +VR RLK+LG D+S CVL++LS+TV+SW  +AE ILRDI+ DD  G   +TL  G FL GE+   SE    ++E  F ++R F D+YIL+EMLSI CLA EASQTFERAVARGAIVA +VAMVLE++  Q  NL+A     + +  D   EG+A+EQ      +F  +L LAETL  SRDP V+GFVKMLYT+LFKW+ D+ +R ++L+RLVD  TS T S+H++DL+L+IL  L  +EQE+ RPVL+M+++V E AN+DRAALWHQL A+++E++R++EEKK E  +M KEK+ I QKLSESEA NTRLKSEMKAE D F+REKK+L EQ ++VESQLEW RSER DEI +L++E+K L DRLH+AETQL+  K+RKRDELKK+ KEKNAL E+LK  E ARKRF+EELKRYATENVTREE+R+SLED++R+LTQTVGQT+ EKREKE+Q+AR EAYI  MESKLQAC            QQ IHTL +SL+EE+SRHAPLYGA LE+LSMKEL+T++ IHEEGLRQIH L  QQRKG   S      H L   H LYP+TPPQ   MA+G+PP LIPNG G+HSNGH+NG+V PWF+H
Sbjct:   19 DQSHPSVSS--SSSEKPLSSSSISPAEDLQVGS--SRDGSGGAQEIVAVDRPGEYSALCRWTVESFTRVKAKALWSKYFDVGGYDCRLLVYPRGDSQALPGYISIYLQIMDPRGTTSSRWDCFASYRLSIVNLVDDSLTIHKDSWHRFSSKKKSHGWCDFTLNSSILDPKMGFLFNNDSLLITADILILNESVSFSRDNNNEGQSLYKENS-------IAGPMPDVLSGKFTWKVNNFSLFKDMIKTQKIMSPVFPAGECNLRISVYQSVVNSQEYISMCLESKETEKTLV-SDRSCWCLFRMSALNQKPGCTHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSEFVNPEAGFLLDDMAVFSTSFHVIKEFSSFTKNGGLIGGRNGAGARKSDGHMGKFTWRIENFTRLKDLLKKRKITGLCIKSKRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDSRS-SSDWSCFVSHRLSVVNQRLEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSATKEYVEAD--STNSVSPTDNSVKKSSFTWKVENFLAFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSAGTDVDNNFWVKYKMGILNQKNPAKSVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVLASDDDQDALTTDPDEIIDSEESEGISGDEEDTFRDFLSRAGFHLTFGENPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPTKVKRLLLPTKIS-CNDRSKLIKSDESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPSEEGSHSEPSLLSPKT-DGCVAATSSESTRERGAAEPSQHLVDERFKSDTDATLSTSAVPSSE-MNGIDLLEKALAIEPMSPPTTSAGQSSDASVQSKTKWPEQSEELLGLIVNSLKTLDAAVPQGCPEPRRRPHSAQKIALVLDRAPKHLQPDLVSLVPKLVEHSEHPLAALALIERLQKPEAEPALREPVYNALSQLECDSEVWEDILSQSFELLSDLNEESLVAAIHFTFKTASQCQHLPEAVNAVRERLKSLGADVSLCVLDYLSKTVHSWPGIAEMILRDINTDDSVGANFATLPCGPFLIGENETASEMADLMEEHIFYANRQFFDVYILLEMLSISCLAEEASQTFERAVARGAIVAQAVAMVLEKQRVQSPNLNATSGDASLKHQDPVLEGEASEQPATGGTEFRIILNLAETLTHSRDPQVRGFVKMLYTILFKWFPDQPFRVQILRRLVDRFTSPTSSSHDLDLELEILAILIFQEQEVARPVLAMLKKVVEHANIDRAALWHQLRANKEELVRLKEEKKIEIQSMTKEKSSITQKLSESEAANTRLKSEMKAEADRFSREKKDLVEQFRDVESQLEWIRSERQDEIDKLSSEKKTLLDRLHEAETQLALQKTRKRDELKKVGKEKNALTEKLKVTEAARKRFEEELKRYATENVTREELRKSLEDQIRQLTQTVGQTKEEKREKEDQIARCEAYIDGMESKLQAC------------QQYIHTLESSLREEISRHAPLYGANLESLSMKELDTIARIHEEGLRQIHAL--QQRKGHTLS------HGLPQGHTLYPTTPPQLPPMAIGLPPQLIPNGSGVHSNGHINGSVRPWFSH 1671          

Query:  265 DHSQPATSSLNSGASEKLPSIPAAAPEDLSVASTPSRDG-GGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSKSPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQ---MAVGMPPSLIPNGVGIHSNGHVNGN 5259
            D S P+ SS  S + + L S   +  EDL V S  SRDG GGAQE V VDR GEYS +CRWTV++F R+KA+ALWSKYF+VGGYDCRLL+YP+GDSQALPGYISIYLQIMDPRGT+SS+WDCFASYRL+IVNL DDS TIH+DSWHRFSSKKKSHGWCDFT +S++ D K+G+LFN DS+LITADILILNESV+F+RD+NN    L            +AGP+ DVLSGKFTWKV NFSLFK+MIKTQKIMSP               S VN  EY+SMCLESK+T+KT+V SDRSCWCLFRMS LNQKP   HMHRDSYGRFAADNKSGDNTSLGWNDYMKMS+FV  E+GFLLDD AVFSTSFHVIKEFSSF+KNGGLI GR+G+GARK DGHMGKF WRIENFTRLKDLLKKRKITGLCIKS+RFQIGNRDCRLIVYPR          VFLEVTD+R+ SSDWSCFVSHRLSVVNQR+EEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETS  +E+ + D  S+N+ S  D + K+SSFTWKVENFL+FKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQS G D+D NFWV+Y+M ++NQKNPAK+VWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEV AS+DDQDALTTDPDE++               FR+ LSRAGFHLT+G+NPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDP KVKRLLLPTK+S  +D  K+IK+DESSPSLMNLLMGVKVLQQA        MVECCQP+E  S+ + S  + K+ DG  AA   +  RE GA E S     ER                   + GI +  K L  +P+ PP TSAG S + +++SKTKWPEQSEELLGLIVNSL+ LD AV            SAQKIALVLD+APKHLQ DLV+LVPKLVEHSEHPLAA ALIERLQKP+AEPALR PV+ ALSQL+C SEVWE +LSQSFE L D N+E LVA I F FK ASQCQHLPEAV +VR RLK+LG D+S CVL++LS+TV+SW  +AE ILRDI+ DD  G   +TL  G FL GE+   SE    ++E  F ++R F D+YIL+EMLSI CLA EASQTFERAVARGAIVA +VAMVLE++  Q  NL+A     + +  D   EG+A+EQ      +F  +L LAETL  SRDP V+GFVKMLYT+LFKW+ D+ +R ++L+RLVD  TS T S+H++DL+L+IL  L  +EQE+ RPVL+M+++V E AN+DRAALWHQL A+++E++R++EEKK E  +M KEK+ I QKLSESEA NTRLKSEMKAE D F+REKK+L EQ ++VESQLEW RSER DEI +L++E+K L DRLH+AETQL+  K+RKRDELKK+ KEKNAL E+LK  E ARKRF+EELKRYATENVTREE+R+SLED++R+LTQTVGQT+ EKREKE+Q+AR EAYI  MESKLQAC            QQ IHTL +SL+EE+SRHAPLYGA LE+LSMKEL+T++ IHEEGLRQIH L  QQRKG   S      H L   H LYP+TPPQ   MA+G+PP LIPNG G+HSNGH+NG+
Sbjct:   19 DQSHPSVSS--SSSEKPLSSSSISPAEDLQVGS--SRDGSGGAQEIVAVDRPGEYSALCRWTVESFTRVKAKALWSKYFDVGGYDCRLLVYPRGDSQALPGYISIYLQIMDPRGTTSSRWDCFASYRLSIVNLVDDSLTIHKDSWHRFSSKKKSHGWCDFTLNSSILDPKMGFLFNNDSLLITADILILNESVSFSRDNNNEGQSLYKENS-------IAGPMPDVLSGKFTWKVNNFSLFKDMIKTQKIMSPVFPAGECNLRISVYQSVVNSQEYISMCLESKETEKTLV-SDRSCWCLFRMSALNQKPGCTHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSEFVNPEAGFLLDDMAVFSTSFHVIKEFSSFTKNGGLIGGRNGAGARKSDGHMGKFTWRIENFTRLKDLLKKRKITGLCIKSKRFQIGNRDCRLIVYPR----------VFLEVTDSRS-SSDWSCFVSHRLSVVNQRLEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSATKEYVEAD--STNSVSPTDNSVKKSSFTWKVENFLAFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSAGTDVDNNFWVKYKMGILNQKNPAKSVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVLASDDDQDALTTDPDEIIDSEESEGISGDEEDTFRDFLSRAGFHLTFGENPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPTKVKRLLLPTKIS-CNDRSKLIKSDESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPSEEGSHSEPSLLSPKT-DGCVAATSSESTRERGAAEPSQHLVDERFKSDTDATLSTSAVPSSE-MNGIDLLEKALAIEPMSPPTTSAGQSSDASVQSKTKWPEQSEELLGLIVNSLKTLDAAVPQGCPEPRRRPHSAQKIALVLDRAPKHLQPDLVSLVPKLVEHSEHPLAALALIERLQKPEAEPALREPVYNALSQLECDSEVWEDILSQSFELLSDLNEESLVAAIHFTFKTASQCQHLPEAVNAVRERLKSLGADVSLCVLDYLSKTVHSWPGIAEMILRDINTDDSVGANFATLPCGPFLIGENETASEMADLMEEHIFYANRQFFDVYILLEMLSISCLAEEASQTFERAVARGAIVAQAVAMVLEKQRVQSPNLNATSGDASLKHQDPVLEGEASEQPATGGTEFRIILNLAETLTHSRDPQVRGFVKMLYTILFKWFPDQPFRVQILRRLVDRFTSPTSSSHDLDLELEILAILIFQEQEVARPVLAMLKKVVEHANIDRAALWHQLRANKEELVRLKEEKKIEIQSMTKEKSSITQKLSESEAANTRLKSEMKAEADRFSREKKDLVEQFRDVESQLEWIRSERQDEIDKLSSEKKTLLDRLHEAETQLALQKTRKRDELKKVGKEKNALTEKLKVTEAARKRFEEELKRYATENVTREELRKSLEDQIRQLTQTVGQTKEEKREKEDQIARCEAYIDGMESKLQAC------------QQYIHTLESSLREEISRHAPLYGANLESLSMKELDTIARIHEEGLRQIHAL--QQRKGHTLS------HGLPQGHTLYPTTPPQLPPMAIGLPPQLIPNGSGVHSNGHINGS 1654          

Query:  280 ATSSLNSGASEKLPSIPAAAPEDLSVA-----STPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTES--SNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDN------PSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKN-----DESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSKSPDGSGAACPLQPDRENG--ATESSD--CPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEH--GPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKF--IGDNFQQTDV------AAEGDANEQLR-IQRD-DFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYP-----STPPQMAVGMPPSLIPNGVGIHSNGHVNGNVGPWF 5274
            AT +  SG + +  S+ A   E   VA     +   R+GG  QESV V++RGE++ VC+WT+  F ++KARALWS+YFEVGGYDCRLL+YP+GDSQALPGY+SIYLQ+ DPRG+SSSKWDCFASYRL +VN  D++K+I RDSWHRFS KKKSHGWCDFTPSSTV D K G++ N ++VLITA+IL+L+ESV+F+R+     NEL              GP  +VLSGKFTWKV N SLFKEMIKTQKIMSP               SSV+GV+YLSMCLESKDT+K+ V  +RSCWCLFRMSVLNQ+   NHMHRDSYGRFAADNKSGDNTSLGWNDYMKM+DFV  E G+L++DTAVFS SFHVIKE S+FSKN G ++ R+   A+K DG+ GKF WRIENFTRLKDLLKKRKITGLCIKSRRFQ+GNRDCRLIVYPRGQSQPPCHLS+FLEVTD RNT +DWSCFVSHRLSVVNQR +E+SVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQD VVFSAEVLILKETS MQE ++ + E+  S  GS   +   R +FTW+VENFL+FKEIMETRKIFSKFFQAGGCELRIGVYESFDT+CIYLESDQS+G D D+NFWVRYRMAVVN K+  +TVWKESSICTKTWNNSVLQFMKVSDM+EADAGFLVRDTVVFVCEILDCCPWFEFSDL+V  S+D+QDAL+TDP+EL+               FR+LL+RAGFHL+YGDN      PSQ Q+TLREKLLMDAGA+A FL GLRVYLDDPAKVKRLLLPTK+S +S G    KN     + SSPSLMNLLMGVKVLQQA        MVECCQP+E     D+  A   +  G         D  NG  A ES D    + ++                      + +P        +   ++    S+     S  KWPEQS+ELLGLIVNSLRAL+GAV            SAQKIALVL+KAPKHLQ DL+ALVPKLV+ SEH L A++L+ERLQ+PDAEPALR P+ GALSQL+  S++WE+VL Q+ + L +  DEPL A + F+FKAA++ Q L  AV +VR R K LG  +SP VL+ +  TV+S  DVAE +LRDID D +  +T  T      +FG++  G  + +     E+   S    +D+  L+EML++P L +EA + FERA+ARGA    SV MVLERR +QRL L  +      N   + V         G   + L  ++ D DF +VL LAE LALSRD  V+ FV  +Y ++FK Y DE Y  RML+ LV+ ATS+T   HEV+L + IL  L  EE+   RPVLSMM +VAE AN +R  LW QL A ED+I+R+R E++AE A + +EKAV+ Q+L +++    RLK+EM+AEID   REKK+++E+I+EVE+QLEW RSER++EI +L  E+K LQDRL D E QL+QLKSRKRDELK+++KEKNALAERLK AE ARKRFDE++KRYATE+VTREEIRQSLEDEVRRLTQTVGQTEG  REKEEQV R EAYI  MESKL ACQ              I TL ASL+EEMSRHAPLYGAGLEALS+ ELETL+ IH+EGLR +  LQQQ  +G+  +  + +  ++ ++  L P     +TPP +AVGM PS++ NG+ +H NGH+NG VGPW+
Sbjct:    5 ATGASGSGGAIE-SSVVAVRGEKNGVARGGENADEPREGG--QESVIVEKRGEHAAVCKWTISQFAKVKARALWSRYFEVGGYDCRLLVYPRGDSQALPGYLSIYLQVTDPRGSSSSKWDCFASYRLCVVNQKDETKSIQRDSWHRFSGKKKSHGWCDFTPSSTVLDGKGGFVVN-EAVLITAEILVLHESVSFSRE-----NELPA----------TGGPAPEVLSGKFTWKVHNLSLFKEMIKTQKIMSPVFPAGDCSLRLSVYQSSVSGVDYLSMCLESKDTEKSSV-PERSCWCLFRMSVLNQRAGMNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMADFVAPEMGYLVEDTAVFSASFHVIKESSTFSKNIGPLSARAN--AKKSDGYQGKFMWRIENFTRLKDLLKKRKITGLCIKSRRFQVGNRDCRLIVYPRGQSQPPCHLSMFLEVTDPRNTCADWSCFVSHRLSVVNQRTDERSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDMVVFSAEVLILKETSTMQELSEYEGEAAASGGGSDTGRIVNRGTFTWRVENFLAFKEIMETRKIFSKFFQAGGCELRIGVYESFDTLCIYLESDQSIGSDPDRNFWVRYRMAVVNVKHGDRTVWKESSICTKTWNNSVLQFMKVSDMVEADAGFLVRDTVVFVCEILDCCPWFEFSDLDVLISDDEQDALSTDPEELLDSDDSEGVSGDEEDIFRSLLARAGFHLSYGDNPPLLLDPSQLQITLREKLLMDAGAVAAFLAGLRVYLDDPAKVKRLLLPTKVSTTSAGGGGGKNAAGRGEASSPSLMNLLMGVKVLQQAIVDLLLDIMVECCQPSEVKKCNDVPAAKPAAAGG--------VDWRNGGSAVESRDSGLSSIDQRLEVGGDGSSGAQAVQSSDSLAVDMPVGRAAALSVSSVQSEPAASQ----ESCPKWPEQSDELLGLIVNSLRALEGAVPQGVPEPRRRPQSAQKIALVLEKAPKHLQPDLIALVPKLVDLSEHSLVAYSLLERLQRPDAEPALRLPMLGALSQLEVSSDIWEQVLQQALDILPELVDEPLAAVMSFVFKAATESQQLLRAVAAVRRRFKKLGPAVSPRVLDVVRSTVSSNADVAEALLRDIDNDSDRSETDITTAGINIVFGDNRDGDGAAQLQAAAEKVAASCWRVADVDFLVEMLTMPTLRIEAQRVFERAIARGAFGEQSVVMVLERRRSQRLILGTRMGASAGNAAASHVQDPLMPGTPGGGIDYLHPVEEDVDFPAVLQLAEALALSRDLRVREFVSTMYAVMFKVYGDEGYHERMLRGLVERATSSTSGPHEVELGMAILTFLVREEEGTARPVLSMMCKVAEAANGERNVLWQQLRAREDDIVRLRNERQAELARVSREKAVLSQRLVDADIAQGRLKAEMRAEIDRVGREKKDMAERIREVENQLEWVRSEREEEIGKLLNEKKGLQDRLRDTEAQLAQLKSRKRDELKRVMKEKNALAERLKTAESARKRFDEDIKRYATESVTREEIRQSLEDEVRRLTQTVGQTEGGLREKEEQVMRCEAYIDGMESKLHACQNY------------IQTLEASLQEEMSRHAPLYGAGLEALSLSELETLARIHDEGLRAVRLLQQQ--RGAGGAEHMANMESMANHSPLPPPLGMYATPPPIAVGM-PSIMANGMSVHGNGHINGTVGPWY 1674          

Query:  319 PSIPAAAPEDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRG----------TSSSKWDCFASYRLAIVNLADD-SKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNT-DSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------------SSVNGVEYLSMCLESKD--------TDKTVVLS----------DRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSG-----ARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTE--SSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMK-VIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSK-SPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAG---VSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDA---KFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLI------PNGVGIHSNGHVNGNVGPWFN 5277
            PS PAAA    +   +PS     +  + +V+RRG+ S  CRWT+ +FPR +AR  +S+YFEVGG+DCRLL+YP+GDSQALPGY+S+YLQ++DP+           +SSSKW+CF SYRL++ + + D SK++ RDSWHRFSSKK+SHGWCDF PS+        YLF   DS++I ADI +L E+ +F                                 G+FTWKV NF  F+EM++TQKIMSP                     S+V+G ++LS+CLESK+        +  + + S          DR CWCLFR+S+LNQKP  +H+H+DSYGRF ADN      SLGW DY+KM DF+  + G+LLD   VFS S HVIKE +SF+++  +I G SG+G     ARK DGH GKF WRIENFTRLK+LLKKRKITGLCIKSR+FQ+GNRDCRLIVYPRGQSQPPC+LSVFLEVTD RN SS+WSCFVSHRLSV+NQ++EE+++ KESQNRYSK+AKDWGWREFVTLT LFDQD+GFLVQDTVVF+AEVLILKET+ +QE +D+D+E  SS +G QID   KR SFTWKVENFLSFK+IMETRKIFSK+FQAGGCELRIGVYESFDTICIYLESDQ  G D DKNFWV Y+MA++NQKN AKTV KESSICTKTWNNSVLQFMKVSD+L+ DAGFLVRDTV+FVCEI+DCCPWF+FSDLEV AS+DDQD L+TDPD+ +               FRNLLSRAGF LTYG+N +QPQVTLREK+L DA AIAGFLTGLRVYLD+PAKVKR+LLPTK+S  + G K V K D SS SL++LLMGV VL+QA        MVECCQP+E       S A+SK SPD +GA+ P + + E   TE +     ERL                   T   +P + L  +   PPE S       E+    S+TKWPEQSEELLGLIV+SLRALD AV            S QKIALVL+K+PK LQ DLVALVPKLV+ SEH LAA AL++ LQKPD EP+LR PVF ALS+L+   ++W++    + E L DSNDEPLV  I ++ KAASQCQH+ +A R+VR RLK+LG ++  CVL+FLS+TV+SW DVA+ +L+DID D E   +C +++       E    +E  H +  QA       SD++ILIEMLSIP L VE SQ  +RA+ RGA     VAMVLERR + RL+L +     + D+ Q   V  +G   E L +Q DDFTSVL L E L+LS +  V+ FV+MLY ++FK Y ++ YR R+LK LV+ AT+T+DS   VD+D+D+LV L  EE  I RPVL+M+REVAE+A  DRA LWHQ+CA+EDE +R+RE+   E     KEK V++Q+L ESEA N  L+SE+KAE DCF REKKELSEQ+ E+E+QLEW RSE+D++I +L  ++K L DRLH+AETQLSQ K+ KR+ELKK+ KEKNALAERLK  E +RKR D+E K++  E  TREEIR+SLE EVRRLTQTVGQTEGEK+EKE+Q+ R EAYI  MESKLQ C            QQ IHTL  S++EEM+RHAP+YG G+EALS+ ELETL+ IHE GLRQIH +  +QRKG   SS  +S  +L H  GLY S+PP MAVG+P SLI      PNG GIH NGH+NG++G WFN
Sbjct:    6 PSPPAAAAAAAADDPSPSASDSPSA-TFSVERRGDASASCRWTLPDFPRTRARTFYSRYFEVGGFDCRLLLYPRGDSQALPGYLSLYLQVLDPKTPTSSSSATTTSSSSKWECFLSYRLSVAHPSPDPSKSLARDSWHRFSSKKRSHGWCDFAPSAAA-----AYLFPPHDSLVIAADISVLAEAASFAE-----------------------------ADGRFTWKVLNFGTFREMVRTQKIMSPAFFPAANAGGSDCGLRISVYQSNVSGADHLSVCLESKEPLVQATSGSSASALPSSAGGSGMPDGDRGCWCLFRVSILNQKPGGSHIHKDSYGRFGADN-----ASLGWGDYIKMDDFLAADGGYLLDGAVVFSASVHVIKESNSFTRSLPMIAGMSGAGSGRAGARKSDGHFGKFVWRIENFTRLKELLKKRKITGLCIKSRKFQVGNRDCRLIVYPRGQSQPPCNLSVFLEVTDPRN-SSEWSCFVSHRLSVINQKLEERTIVKESQNRYSKSAKDWGWREFVTLTVLFDQDAGFLVQDTVVFAAEVLILKETATIQELSDEDSEACSSGSGCQIDSLPKRPSFTWKVENFLSFKDIMETRKIFSKYFQAGGCELRIGVYESFDTICIYLESDQPSGFDPDKNFWVHYKMAIINQKNSAKTVCKESSICTKTWNNSVLQFMKVSDLLDTDAGFLVRDTVIFVCEIIDCCPWFDFSDLEVLASDDDQDDLSTDPDDFIESEDSEDMSGDEEDMFRNLLSRAGFSLTYGENYTQPQVTLREKILTDASAIAGFLTGLRVYLDNPAKVKRMLLPTKVSTRAGGKKDVSKCDSSSTSLISLLMGVSVLKQAIIDLLLDIMVECCQPSEERPAYVSSSASSKTSPDSNGASSPPELNVEGELTECAFSNKYERLKPGNDDIHHRLSVQNTDKCTN-DIPARVLE-QSCSPPEVSGADLLEDEDSDQASRTKWPEQSEELLGLIVSSLRALDSAVPHGCPEPRRRPQSVQKIALVLEKSPKKLQPDLVALVPKLVDSSEHSLAACALLDHLQKPDTEPSLRLPVFNALSELEFDCDIWKQASFHALELLADSNDEPLVEAITYVLKAASQCQHIAQAARAVRWRLKDLGTEVPLCVLDFLSKTVHSWSDVADALLKDIDYDCEPDSSCLSMSCSTSSTDEFS--AEGMHSLQGQAVHGKDHLSDVFILIEMLSIPRLFVEVSQVLQRALLRGAFGLQLVAMVLERRHSHRLSLKSGTGTMVNDS-QNKQVLLDGQF-EHLPVQEDDFTSVLALGEVLSLSTETRVQDFVRMLYAIIFKIYTEDHYRYRILKGLVERATNTSDSCRAVDIDMDVLVFLVKEEFGIARPVLNMLREVAEVAQADRANLWHQICATEDENMRLREDMDMEQTKFTKEKDVLMQQLIESEAANAHLRSELKAEKDCFVREKKELSEQMLEMENQLEWVRSEKDEQIVKLTADKKNLHDRLHEAETQLSQFKAWKREELKKITKEKNALAERLKGVEASRKRVDDEFKQFVAEAQTREEIRKSLEGEVRRLTQTVGQTEGEKKEKEDQITRCEAYIDGMESKLQVC------------QQYIHTLETSIQEEMARHAPVYGVGVEALSLDELETLTNIHERGLRQIHAI--RQRKG---SSHRLSAPSLPHVPGLY-SSPPSMAVGLPSSLIPTSSVAPNGAGIHGNGHMNGSMGSWFN 1665          

Query:  265 DHSQPATSSLNSGASEKLPSIPAAAPEDLSVASTPSRDG-GGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSKSPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQ---MAVGMPPSLIPNGVGIHSNGHVNGNVGPWFNH 5280
            D S P+ SS  S + + L S   +  EDL V S  SRDG GGAQE V VDR GEYS +CRWTV++F R+KA+ALWSKYF+VGGYDCRLL+YP+GDSQALPGYISIYLQIMDPRGT+SS+WDCFASYRL+IVNL DDS TIH+DSWHRFSSKKKSHGWCDFT +S++ D K+G+LFN DS+LITADILILNESV+F+RD+NN    L            +AGP+ DVLSGKFTWKV NFSLFK+MIKTQKIMSP               S VN  EY+SMCLESK+T+KT+V SDRSCWCLFRMS LNQKP   HMHRDSYGRFAADNKSGDNTSLGWNDYMKMS+FV  E+GFLLDD AVFSTSFHVIKEFSSF+KNGGLI GR+G+GARK DGHMGKF WRIENFTRLKDLLKKRKITGLCIKS+RFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTD+R+ SSDWSCFVSHRLSVVNQR+EEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETS  +E+ + D  S+N+ S  D + K+SSFTWKVENFL+FKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQS G D+D NFWV+Y+M ++NQKNPAK+VWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEV AS+DDQDALTTDPDE++               FR+ LSRAGFHLT+G+NPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDP KVKRLLLPTK+S  +D  K+IK+DESSPSLMNLLMGVKVLQQA        MVECCQP+E  S+ + S  + K+ DG  AA   +  RE GA E S     ER                   + GI +  K L  +P+ PP TSAG S + +++SKTKWPEQSEELLGLIVNSL+ LD AV            SAQKIALVLD+APKHLQ DLV+LVPKLVEHSEHPLAA ALIERLQKP+AEPALR PV+ ALSQL+C SEVWE +LSQSFE L D N+E LVA I F FK ASQCQHLPEAV +VR RLK+LG D+S CVL++LS+TV+SW  +AE ILRDI+ DD  G   +TL  G FL GE+   SE    ++E  F ++R F D+YIL+EMLSI CLA EASQTFERAVARGAIVA +VAMVLE++  Q  NL+A     + +  D   EG+A+EQ      +F  +L LAETL  SRDP V+GFVKMLYT+LFKW+ D+ +R ++L+RLVD  TS T S+H++DL+L+IL  L  +EQE+ RPVL+M+++V E AN+DRAALWHQL A+++E++R++EEKK E  +M KEK+ I QKLSESEA NTRLKSEMKAE D F+REKK+L EQ ++VESQLEW RSER DEI +L++E+K L DRLH+AETQL+  K+RKRDELKK+ KEKNAL E+LK  E ARKRF+EELKRYATENVTREE+R+SLED++R+LTQTVGQT+ EKREKE+Q+AR EAYI  MESKLQAC            QQ IHTL +SL+EE+SRHAPLYGA LE+LSMKEL+T++ IHEEGLRQIH L  QQRKG   S      H L   H LYP+TPPQ   MA+G+PP LIPNG G+HSNGH+NG+V PWF+H
Sbjct:   19 DQSHPSVSS--SSSEKPLSSSSISPAEDLQVGS--SRDGSGGAQEIVAVDRPGEYSALCRWTVESFTRVKAKALWSKYFDVGGYDCRLLVYPRGDSQALPGYISIYLQIMDPRGTTSSRWDCFASYRLSIVNLVDDSLTIHKDSWHRFSSKKKSHGWCDFTLNSSILDPKMGFLFNNDSLLITADILILNESVSFSRDNNNEGQSLYKENS-------IAGPMPDVLSGKFTWKVNNFSLFKDMIKTQKIMSPVFPAGECNLRISVYQSVVNSQEYISMCLESKETEKTLV-SDRSCWCLFRMSALNQKPGCTHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSEFVNPEAGFLLDDMAVFSTSFHVIKEFSSFTKNGGLIGGRNGAGARKSDGHMGKFTWRIENFTRLKDLLKKRKITGLCIKSKRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDSRS-SSDWSCFVSHRLSVVNQRLEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSATKEYVEAD--STNSVSPTDNSVKKSSFTWKVENFLAFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSAGTDVDNNFWVKYKMGILNQKNPAKSVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVLASDDDQDALTTDPDEIIDSEESEGISGDEEDTFRDFLSRAGFHLTFGENPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPTKVKRLLLPTKIS-CNDRSKLIKSDESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPSEEGSHSEPSLLSPKT-DGCVAATSSESTRERGAAEPSQHLVDERFKSDTDATLSTSAVPSSE-MNGIDLLEKALAIEPMSPPTTSAGQSSDASVQSKTKWPEQSEELLGLIVNSLKTLDAAVPQGCPEPRRRPHSAQKIALVLDRAPKHLQPDLVSLVPKLVEHSEHPLAALALIERLQKPEAEPALREPVYNALSQLECDSEVWEDILSQSFELLSDLNEESLVAAIHFTFKTASQCQHLPEAVNAVRERLKSLGADVSLCVLDYLSKTVHSWPGIAEMILRDINTDDSVGANFATLPCGPFLIGENETASEMADLMEEHIFYANRQFFDVYILLEMLSISCLAEEASQTFERAVARGAIVAQAVAMVLEKQRVQSPNLNATSGDASLKHQDPVLEGEASEQPATGGTEFRIILNLAETLTHSRDPQVRGFVKMLYTILFKWFPDQPFRVQILRRLVDRFTSPTSSSHDLDLELEILAILIFQEQEVARPVLAMLKKVVEHANIDRAALWHQLRANKEELVRLKEEKKIEIQSMTKEKSSITQKLSESEAANTRLKSEMKAEADRFSREKKDLVEQFRDVESQLEWIRSERQDEIDKLSSEKKTLLDRLHEAETQLALQKTRKRDELKKVGKEKNALTEKLKVTEAARKRFEEELKRYATENVTREELRKSLEDQIRQLTQTVGQTKEEKREKEDQIARCEAYIDGMESKLQAC------------QQYIHTLESSLREEISRHAPLYGANLESLSMKELDTIARIHEEGLRQIHAL--QQRKGHTLS------HGLPQGHTLYPTTPPQLPPMAIGLPPQLIPNGSGVHSNGHINGSVRPWFSH 1671          

Query:  286 SSLNSGASEKLPSIPAAAPEDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELV 2376
            SS +S A +  PSI +  P      S+   + GGAQE V VDR GEY+ +CRWTV++F R+KA+ALWSKYF+VGGYDCRLL+YP+GDSQALPG ISIYLQI+DPRGTSSS WDCFASY+L+I+N  DDS TI ++SWHRFS+KK+SHGWCDFT +S+V D K+G+LFN DS+LITADI+ILNESV+F+ D+NN +               V G ++DVLSG FTW V+NFS+FKEMIKTQKI SP               S VN  EY SMCL+S DT+K+V LSD+S WCLF MS LNQK    +M+++SYGRFAADNKSGDNT LGWNDYMKMSDFV  ++G+LLDD AVFSTSF VIKEFSSF+KNG   TG         +G+MGKF+WRIENFT L DLL+KRKITGL IKS+RFQIGNRDCRLIVYPRGQSQPP HLS+FLEVTD+R++SSDWSCFVSHRLSVVNQR EEKSVTKESQNR+SKA KDWGWREFVTLTSLFDQDSGFLVQD+VVFS EVL+LKETS+ +++T+   ES+++ SQIDK  K SSFTWKVENFL+FK IME RKIFSKFFQAGGCELRIGVYESFDTICIYLES QS G D+D N WV+Y+M ++NQKNPAK+VWKESS+CTKTWNNSVL FMKVSDMLEADAGFLVRDT+VFVCEILDCCPWFEFSDLEV AS+D QDALTT+PDE++
Sbjct:    3 SSSSSAADQSHPSISSEKP-----LSSSRDESGGAQEIVAVDRPGEYTALCRWTVESFTRVKAKALWSKYFDVGGYDCRLLVYPRGDSQALPGSISIYLQIIDPRGTSSSLWDCFASYQLSIINHVDDSLTIRKNSWHRFSNKKRSHGWCDFTLNSSVLDPKMGFLFNNDSLLITADIMILNESVSFSIDNNNES---------------VVGSMTDVLSGTFTWTVENFSMFKEMIKTQKITSPVFVAGECFLRIGVYQSVVNAQEYFSMCLDSTDTEKSV-LSDKSSWCLFSMSALNQKHGCTNMNKESYGRFAADNKSGDNTGLGWNDYMKMSDFVNPDAGYLLDDKAVFSTSFDVIKEFSSFTKNG---TG---------NGYMGKFSWRIENFTSLVDLLEKRKITGLYIKSKRFQIGNRDCRLIVYPRGQSQPPSHLSIFLEVTDSRSSSSDWSCFVSHRLSVVNQRSEEKSVTKESQNRFSKAEKDWGWREFVTLTSLFDQDSGFLVQDSVVFSVEVLMLKETSLTKDYTE--AESASSVSQIDKTVK-SSFTWKVENFLAFKGIMEKRKIFSKFFQAGGCELRIGVYESFDTICIYLESGQSAGNDVDNNLWVKYKMGILNQKNPAKSVWKESSLCTKTWNNSVLLFMKVSDMLEADAGFLVRDTLVFVCEILDCCPWFEFSDLEVLASDDVQDALTTNPDEVI 678          

Query: 1408 KFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILK 1824
            KF W I  FTRL        +         F +G    R++++P+G +    HLS++L+V DA N    WS +    L+VVNQ     S+ KE+Q++++    DWG+  F+ L+ L++   G+LV DTV+  AEV + K
Sbjct:   54 KFTWTIPMFTRLNTRKHYSDV---------FVVGGYKWRILIFPKGNNVD--HLSMYLDVADAANLPYGWSRYSQFSLAVVNQVNNRYSIRKETQHQFNARESDWGFTSFMPLSELYEPTRGYLVNDTVLIEAEVAVRK 181          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILI 825
            WT+  F R+  R  +S  F VGGY  R+LI+PKG++     ++S+YL + D        W  ++ + LA+VN  ++  +I +++ H+F++++   G+  F P S +++   GYL N D+VLI A++ +
Sbjct:   57 WTIPMFTRLNTRKHYSDVFVVGGYKWRILIFPKGNNV---DHLSMYLDVADAANLPYG-WSRYSQFSLAVVNQVNNRYSIRKETQHQFNARESDWGFTSFMPLSELYEPTRGYLVN-DTVLIEAEVAV 179          

Query: 1408 KFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILK 1824
            KF W I  FTRL        +         F +G    R++++P+G +    HLS++L+V DA N    WS +    L+VVNQ     S+ KE+Q++++    DWG+  F+ L+ L++   G+LV DTV+  AEV + K
Sbjct:   55 KFTWTIPMFTRLNTRKHYSDV---------FVVGGYKWRILIFPKGNNVD--HLSMYLDVADAANLPYGWSRYSQFSLAVVNQVNNRYSIRKETQHQFNARESDWGFTSFMPLSELYEPTRGYLVNDTVLIEAEVAVRK 182          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILI 825
            WT+  F R+  R  +S  F VGGY  R+LI+PKG++     ++S+YL + D        W  ++ + LA+VN  ++  +I +++ H+F++++   G+  F P S +++   GYL N D+VLI A++ +
Sbjct:   58 WTIPMFTRLNTRKHYSDVFVVGGYKWRILIFPKGNNV---DHLSMYLDVADAANLPYG-WSRYSQFSLAVVNQVNNRYSIRKETQHQFNARESDWGFTSFMPLSELYEPTRGYLVN-DTVLIEAEVAV 180          

Query: 1408 KFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILK 1824
            KF W I NF+R         +         F +G    R++++P+G +    HLS++L+V+DA +    WS +    L+VVNQ     +V KE+Q++++    DWG+  F+ L+ L+D   G+LV DTV+  AEV + K
Sbjct:   56 KFTWTIPNFSRQNTRKHYSDV---------FVVGGYKWRILIFPKGNNVD--HLSMYLDVSDAASLPYGWSRYAQFSLAVVNQIHTRYTVRKETQHQFNARESDWGFTSFMPLSELYDPSRGYLVNDTVLVEAEVAVRK 183          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILI 825
            WT+ NF R   R  +S  F VGGY  R+LI+PKG++     ++S+YL + D        W  +A + LA+VN      T+ +++ H+F++++   G+  F P S ++D   GYL N D+VL+ A++ +
Sbjct:   59 WTIPNFSRQNTRKHYSDVFVVGGYKWRILIFPKGNNV---DHLSMYLDVSDAASLPYG-WSRYAQFSLAVVNQIHTRYTVRKETQHQFNARESDWGFTSFMPLSELYDPSRGYLVN-DTVLVEAEVAV 181          

Query: 1843 EFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVY---ESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESS--ICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEI 2280
            E T  +T +S   +Q  ++     FTW + NF        TRK +S  F  GG + RI ++    + D + +YL+   +       + + ++ +AVVNQ +   TV KE+      +  +     FM +S++ +   G+LV DTV+   E+
Sbjct:   33 EVTQPETAASTVENQPAEDPPTLKFTWTIPNFSR----QNTRKHYSDVFVVGGYKWRILIFPKGNNVDHLSMYLDVSDAASLPYGWSRYAQFSLAVVNQIHTRYTVRKETQHQFNARESDWGFTSFMPLSELYDPSRGYLVNDTVLVEAEV 179          

Query: 1408 KFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILK 1824
            KF W I NF+R         +         F +G    R++++P+G +    HLS++L+V+DA +    WS +    L+VVNQ     +V KE+Q++++    DWG+  F+ L+ L+D   G+LV DTV+  AEV + K
Sbjct:   55 KFTWTIPNFSRQNTRKHYSDV---------FVVGGYKWRILIFPKGNNVD--HLSMYLDVSDAASLPYGWSRYAQFSLAVVNQIHTRYTVRKETQHQFNARESDWGFTSFMPLSELYDPSRGYLVNDTVLVEAEVAVRK 182          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILI 825
            WT+ NF R   R  +S  F VGGY  R+LI+PKG++     ++S+YL + D        W  +A + LA+VN      T+ +++ H+F++++   G+  F P S ++D   GYL N D+VL+ A++ +
Sbjct:   58 WTIPNFSRQNTRKHYSDVFVVGGYKWRILIFPKGNNV---DHLSMYLDVSDAASLPYG-WSRYAQFSLAVVNQIHTRYTVRKETQHQFNARESDWGFTSFMPLSELYDPSRGYLVN-DTVLVEAEVAV 180          

Query: 1843 EFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVY---ESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESS--ICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEI 2280
            E T  +T +S   +Q  ++     FTW + NF        TRK +S  F  GG + RI ++    + D + +YL+   +       + + ++ +AVVNQ +   TV KE+      +  +     FM +S++ +   G+LV DTV+   E+
Sbjct:   32 EVTQPETAASTVENQPAEDPPTLKFTWTIPNFSR----QNTRKHYSDVFVVGGYKWRILIFPKGNNVDHLSMYLDVSDAASLPYGWSRYAQFSLAVVNQIHTRYTVRKETQHQFNARESDWGFTSFMPLSELYDPSRGYLVNDTVLVEAEV 178          

Query: 1408 KFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILK 1824
            KF W I NF+R         +         F +G    R++++P+G +    HLS++L+V+DA +    WS +    L+VVNQ     +V KE+Q++++    DWG+  F+ L+ L+D   G+LV DTV+  AEV + K
Sbjct:   56 KFTWTIPNFSRQNTRKHYSDV---------FVVGGYKWRILIFPKGNNVD--HLSMYLDVSDAASLPYGWSRYAQFSLAVVNQIHTRYTVRKETQHQFNARESDWGFTSFMPLSELYDPSRGYLVNDTVLVEAEVAVRK 183          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILI 825
            WT+ NF R   R  +S  F VGGY  R+LI+PKG++     ++S+YL + D        W  +A + LA+VN      T+ +++ H+F++++   G+  F P S ++D   GYL N D+VL+ A++ +
Sbjct:   59 WTIPNFSRQNTRKHYSDVFVVGGYKWRILIFPKGNNV---DHLSMYLDVSDAASLPYG-WSRYAQFSLAVVNQIHTRYTVRKETQHQFNARESDWGFTSFMPLSELYDPSRGYLVN-DTVLVEAEVAV 181          

Query: 1843 EFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVY---ESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESS--ICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEI 2280
            E T  +T +S   +Q  ++     FTW + NF        TRK +S  F  GG + RI ++    + D + +YL+   +       + + ++ +AVVNQ +   TV KE+      +  +     FM +S++ +   G+LV DTV+   E+
Sbjct:   33 EVTQPETAASTVENQPAEDPPTLKFTWTIPNFSR----QNTRKHYSDVFVVGGYKWRILIFPKGNNVDHLSMYLDVSDAASLPYGWSRYAQFSLAVVNQIHTRYTVRKETQHQFNARESDWGFTSFMPLSELYDPSRGYLVNDTVLVEAEV 179          

Query: 1408 KFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILK 1824
            KF W I+NF+  +  +         + S +F IG    RL+VYP G ++   HLS+FLEV D R+    WS    + L++VNQ  ++ S   E+   +++    WG    + LT L  +D GFLV D +   AEV +L+
Sbjct:    8 KFTWVIQNFSSSQSRV---------VPSNQFVIGGCKWRLLVYPEGFNKSGDHLSLFLEVADPRSLPPGWSRHARYLLTIVNQHSDKISKRNEATKWFNQKIPGWGLSAMIPLTKLHAKDGGFLVNDELKIVAEVNVLE 137          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILIL 828
            W +QNF   ++R + S  F +GG   RLL+YP+G +++   ++S++L++ DPR      W   A Y L IVN   D  +   ++   F+ K    G     P + +     G+L N D + I A++ +L
Sbjct:   11 WVIQNFSSSQSRVVPSNQFVIGGCKWRLLVYPEGFNKS-GDHLSLFLEVADPRSLPPG-WSRHARYLLTIVNQHSDKISKRNEATKWFNQKIPGWGLSAMIPLTKLHAKDGGFLVN-DELKIVAEVNVL 136          

Query: 1423 IENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPC--HLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEK-SVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFD------TICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNP-AKTVWKESSICTKT-WNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEIL 2283
            I +F+ +KD        G   +S  F+      RL++Y +G  +     H+S++  + +       W   V  +L V N+++++  SVT  +  RY+ A K+WG+ + ++L + ++ + G+LVQDT  F AE+ I+  T   ++ T       N             FTWK+  F      +E +  +S  F  G    R+G             + I+L +       +  N W    + + NQ++   K ++  +    ++ +   V   + +S++ +A  G++V D ++F  E++
Sbjct:   67 ITSFSVIKD-------RGEPYESSIFEAAGYKWRLVLYVKGNPKGGINNHISLYARIEETETLPRGWEVNVDLKLFVHNRKLKKYLSVTDGTVKRYNDAKKEWGFTQLISLPTFYNANEGYLVQDTASFGAEIFIVNPTEKQEKVTFISNPPDNV------------FTWKILRF----STLEDKFYYSDDFLVGDRYWRLGFNPKGSGGGRPHALPIFLYAQGHKANAVVTNTWGAVNLRLKNQRSSNHKQLYSAAWYPIRSDYGVGVNNIILMSELKDASKGYMVNDAIIFEAEMV 341          

Query: 1408 KFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPC--------HLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQ-EFTDQDTESSNAGSQIDKNGKRSSFTWKVENF-LSFKEIMETRKIFSK 1983
            KF W I+NF+ L+           C  S    I + + RL  YP G +            HLS++LEV D  +    W  +   R +VVNQ  E  SV +E +  + K A +WGW E ++LT L D +SGF+V   ++  AEV   +  S  Q      D+E +  G        +   T  V+ F +   ++ + ++IF K
Sbjct:   11 KFVWVIKNFSSLQ--------LQDCYVSDPVLIHDVNWRLFAYPEGSNGDHLLFKKNNGDHLSLYLEV-DFESLPCGWRQYTQFRFTVVNQISEHSSVKREGRKWFDKKAPEWGWEEMISLTKLNDINSGFVVNGELMIVAEVETFEAVSTSQVAAVRDDSEWTLLGYYSSSEEDKDDVTVVVKGFHVLDSQVNQVKEIFEK 203          

Query:  265 DHSQPATSSLNSGASEKLPSIPAAAPEDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRD--SNNNNNELQXXXXXXXXXXXVA-GPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPX-TNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSK-SPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAG-VSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVNGNVG 5265
            D S  ATSS  + A+   P+      +D++V +T     G A E+VT+DRRGEYS +C+WTVQNFPR+KARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRL+I N  DDSKTIHRDSWHRFSSKKKSHGWCDFTP+STVFDSKLGYLFN D VLITADILILNESV+F RD  S+ +NNE+Q           V  GPVSDVLSGKFTWKV NFSLFKEMIKTQKIMS                SSVNG +YLSMCLESKDT+KT V SDRSCWCLFRMSVLNQK   +NH+HRDSYGRFAADNKSGDNTSLGWNDYMKM+DFVG ESGFL+DDTAVFSTSFHVIKEFSSFSKNGGL  GR G GARK DGHMGKF WRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTD+RNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQ+F DQDTES+N+ SQID  GKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVG D DKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLE DAGFLVRDTVVFVCEILDCCPWFEFSDLEV ASEDDQDALTTDPDEL+               FRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGS+D  K  K DESSPSLMNLLMGVKVLQQA        MVECCQP+EG+S  D SDA+ K S DGSGAA PL+ DRE+GATES+  P  ERL                  + G G+P + LPG+PI PP T+AG  S N +LRSKTKWPEQSEELLGLIVNSLRALDGAV            SAQKIALVLDKAPKHLQ DLV+LVPKLVEH+EHPL A+AL+ERLQKPDAEPALR PVFGALSQL+CGS+VWERVL QSF+ L DSNDEPL ATIDFIFKAASQCQHLPEAVRSVR RLK LG D+SP VL+FLS+TVNSWGDVAETILRDIDCDD+ GD+CSTL  GLFLFGE+   +ER   VDEQ F SS  FSDIYILIEMLSIPCLA+EASQTFERAV RGAI+A SVA+VLERRLAQRLN +A+F+ +NFQQ D   EG+A+EQLR+QRDDF+ VLGLAETLALSRD CVKGFVKMLY +LFKWYA+E  RGRMLKRLVD ATSTTD++ +VDLDLDIL  L  EEQEI++PVLSMMREVAELANVDRAALWHQLCASEDEIIRMR+E+KAE + M +EKA + QKLS+SEATN RLKSEM+AE+D FAREKKELSEQI EVESQLEW RSERDDEI +L  E+KVLQDRLHDAETQLSQLKSRKRDELK++VKEKNAL ERLK+AE ARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVAR EAYI  MESKLQAC            QQ IHTL ASL+EEM+RHAPLYGAGLEALSM+ELET+S IHEEGLRQIH L  QQRKGSP +SP VSPH L HNHG+YP+ PP MAVG+PP LI NGVGIHSNGH+NG VG
Sbjct:   32 DQSSLATSSSTTTAT---PTSTTTTIDDITVGTTRDGTNGAAAEAVTIDRRGEYSAICKWTVQNFPRVKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLSIFNPLDDSKTIHRDSWHRFSSKKKSHGWCDFTPASTVFDSKLGYLFNNDCVLITADILILNESVSFIRDNSSSTSNNEVQSGVSLSISSNSVVVGPVSDVLSGKFTWKVHNFSLFKEMIKTQKIMSQVFPAGECNLRISVYQSSVNGTDYLSMCLESKDTEKTSV-SDRSCWCLFRMSVLNQKAGGSNHVHRDSYGRFAADNKSGDNTSLGWNDYMKMADFVGAESGFLVDDTAVFSTSFHVIKEFSSFSKNGGLNGGRIGGGARKSDGHMGKFTWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDSRNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQDFIDQDTESTNSASQIDGVGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGSDPDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLETDAGFLVRDTVVFVCEILDCCPWFEFSDLEVLASEDDQDALTTDPDELIDSDDSEGISGDEEDIFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSNDAKKATKADESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPSEGSSNDDSSDAHPKPSLDGSGAASPLESDRESGATESARFPVHERLDSGLDDSTRASAVQSSD-INGTGIPGQALPGQPIHPPVTTAGGASGNASLRSKTKWPEQSEELLGLIVNSLRALDGAVPQGCPEPRRRPQSAQKIALVLDKAPKHLQPDLVSLVPKLVEHAEHPLVAYALLERLQKPDAEPALRIPVFGALSQLECGSDVWERVLFQSFDLLADSNDEPLAATIDFIFKAASQCQHLPEAVRSVRSRLKILGADVSPFVLDFLSKTVNSWGDVAETILRDIDCDDDLGDSCSTLPCGLFLFGENASAAERLQVVDEQTFHSSSHFSDIYILIEMLSIPCLALEASQTFERAVGRGAIMAQSVAIVLERRLAQRLNFNARFVAENFQQEDAILEGEASEQLRVQRDDFSVVLGLAETLALSRDLCVKGFVKMLYMILFKWYANEPCRGRMLKRLVDHATSTTDNSRDVDLDLDILAILVCEEQEIVKPVLSMMREVAELANVDRAALWHQLCASEDEIIRMRDERKAEISNMAREKANLSQKLSDSEATNNRLKSEMRAEMDRFAREKKELSEQIHEVESQLEWVRSERDDEIIKLTVEKKVLQDRLHDAETQLSQLKSRKRDELKRVVKEKNALTERLKSAEAARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARCEAYIDGMESKLQAC------------QQYIHTLEASLQEEMTRHAPLYGAGLEALSMQELETISRIHEEGLRQIHVL--QQRKGSP-ASPHVSPHTLPHNHGMYPAAPPPMAVGLPP-LISNGVGIHSNGHINGAVG 1698          

Query:  265 DHSQPATSSLNSGASEKLPSIPAAAPEDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRD--SNNNNNELQXXXXXXXXXXXVA-GPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPX-TNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSK-SPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAG-VSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVNGNVG 5265
            D S  ATSS  + A+   P+      +D++V +T     G A E+VT+DRRGEYS +C+WTVQNFPR+KARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRL+I N  DDSKTIHRDSWHRFSSKKKSHGWCDFTP+STVFDSKLGYLFN D VLITADILILNESV+F RD  S+ +NNE+Q           V  GPVSDVLSGKFTWKV NFSLFKEMIKTQKIMS                SSVNG +YLSMCLESKDT+KT V SDRSCWCLFRMSVLNQK   +NH+HRDSYGRFAADNKSGDNTSLGWNDYMKM+DFVG ESGFL+DDTAVFSTSFHVIKEFSSFSKNGGL  GR G GARK DGHMGKF WRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPR          VFLEVTD+RNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQ+F DQDTES+N+ SQID  GKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVG D DKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLE DAGFLVRDTVVFVCEILDCCPWFEFSDLEV ASEDDQDALTTDPDEL+               FRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGS+D  K  K DESSPSLMNLLMGVKVLQQA        MVECCQP+EG+S  D SDA+ K S DGSGAA PL+ DRE+GATES+  P  ERL                  + G G+P + LPG+PI PP T+AG  S N +LRSKTKWPEQSEELLGLIVNSLRALDGAV            SAQKIALVLDKAPKHLQ DLV+LVPKLVEH+EHPL A+AL+ERLQKPDAEPALR PVFGALSQL+CGS+VWERVL QSF+ L DSNDEPL ATIDFIFKAASQCQHLPEAVRSVR RLK LG D+SP VL+FLS+TVNSWGDVAETILRDIDCDD+ GD+CSTL  GLFLFGE+   +ER   VDEQ F SS  FSDIYILIEMLSIPCLA+EASQTFERAV RGAI+A SVA+VLERRLAQRLN +A+F+ +NFQQ D   EG+A+EQLR+QRDDF+ VLGLAETLALSRD CVKGFVKMLY +LFKWYA+E  RGRMLKRLVD ATSTTD++ +VDLDLDIL  L  EEQEI++PVLSMMREVAELANVDRAALWHQLCASEDEIIRMR+E+KAE + M +EKA + QKLS+SEATN RLKSEM+AE+D FAREKKELSEQI EVESQLEW RSERDDEI +L  E+KVLQDRLHDAETQLSQLKSRKRDELK++VKEKNAL ERLK+AE ARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVAR EAYI  MESKLQAC            QQ IHTL ASL+EEM+RHAPLYGAGLEALSM+ELET+S IHEEGLRQIH L  QQRKGSP +SP VSPH L HNHG+YP+ PP MAVG+PP LI NGVGIHSNGH+NG VG
Sbjct:   21 DQSSLATSSSTTTAT---PTSTTTTIDDITVGTTRDGTNGAAAEAVTIDRRGEYSAICKWTVQNFPRVKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLSIFNPLDDSKTIHRDSWHRFSSKKKSHGWCDFTPASTVFDSKLGYLFNNDCVLITADILILNESVSFIRDNSSSTSNNEVQSGVSLSISSNSVVVGPVSDVLSGKFTWKVHNFSLFKEMIKTQKIMSQVFPAGECNLRISVYQSSVNGTDYLSMCLESKDTEKTSV-SDRSCWCLFRMSVLNQKAGGSNHVHRDSYGRFAADNKSGDNTSLGWNDYMKMADFVGAESGFLVDDTAVFSTSFHVIKEFSSFSKNGGLNGGRIGGGARKSDGHMGKFTWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPR----------VFLEVTDSRNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQDFIDQDTESTNSASQIDGVGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGSDPDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLETDAGFLVRDTVVFVCEILDCCPWFEFSDLEVLASEDDQDALTTDPDELIDSDDSEGISGDEEDIFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSNDAKKATKADESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPSEGSSNDDSSDAHPKPSLDGSGAASPLESDRESGATESARFPVHERLDSGLDDSTRASAVQSSD-INGTGIPGQALPGQPIHPPVTTAGGASGNASLRSKTKWPEQSEELLGLIVNSLRALDGAVPQGCPEPRRRPQSAQKIALVLDKAPKHLQPDLVSLVPKLVEHAEHPLVAYALLERLQKPDAEPALRIPVFGALSQLECGSDVWERVLFQSFDLLADSNDEPLAATIDFIFKAASQCQHLPEAVRSVRSRLKILGADVSPFVLDFLSKTVNSWGDVAETILRDIDCDDDLGDSCSTLPCGLFLFGENASAAERLQVVDEQTFHSSSHFSDIYILIEMLSIPCLALEASQTFERAVGRGAIMAQSVAIVLERRLAQRLNFNARFVAENFQQEDAILEGEASEQLRVQRDDFSVVLGLAETLALSRDLCVKGFVKMLYMILFKWYANEPCRGRMLKRLVDHATSTTDNSRDVDLDLDILAILVCEEQEIVKPVLSMMREVAELANVDRAALWHQLCASEDEIIRMRDERKAEISNMAREKANLSQKLSDSEATNNRLKSEMRAEMDRFAREKKELSEQIHEVESQLEWVRSERDDEIIKLTVEKKVLQDRLHDAETQLSQLKSRKRDELKRVVKEKNALTERLKSAEAARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARCEAYIDGMESKLQAC------------QQYIHTLEASLQEEMTRHAPLYGAGLEALSMQELETISRIHEEGLRQIHVL--QQRKGSP-ASPHVSPHTLPHNHGMYPAAPPPMAVGLPP-LISNGVGIHSNGHINGAVG 1677          

Query:  265 DHSQPATSSLNSGASEKLPSIPAAAPEDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRD--SNNNNNELQXXXXXXXXXXXVA-GPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPX-TNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSK-SPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAG-VSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVNGNVG 5265
            D S  ATSS  + A+   P+      +D++V +T     G A E+VT+DRRGEYS +C+WTVQNFPR+KARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRL+I N  DDSKTIHRDSWHRFSSKKKSHGWCDFTP+STVFDSKLGYLFN D VLITADILILNESV+F RD  S+ +NNE+Q           V  GPVSDVLSGKFTWKV NFSLFKEMIKTQKIMS                SSVNG +YLSMCLESKDT+KT V SDRSCWCLFRMSVLNQK   +NH+HRDSYGRFAADNKSGDNTSLGWNDYMKM+DFVG ESGFL+DDTAVFSTSFHVIKEFSSFSKNGGL  GR G GARK DGHMGKF WRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPR          VFLEVTD+RNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQ+F DQDTES+N+ SQID  GKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVG D DKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLE DAGFLVRDTVVFVCEILDCCPWFEFSDLEV ASEDDQDALTTDPDEL+               FRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGS+D  K  K DESSPSLMNLLMGVKVLQQA        MVECCQP+EG+S  D SDA+ K S DGSGAA PL+ DRE+GATES+  P  ERL                  + G G+P + LPG+PI PP T+AG  S N +LRSKTKWPEQSEELLGLIVNSLRALDGAV            SAQKIALVLDKAPKHLQ DLV+LVPKLVEH+EHPL A+AL+ERLQKPDAEPALR PVFGALSQL+CGS+VWERVL QSF+ L DSNDEPL ATIDFIFKAASQCQHLPEAVRSVR RLK LG D+SP VL+FLS+TVNSWGDVAETILRDIDCDD+ GD+CSTL  GLFLFGE+   +ER   VDEQ F SS  FSDIYILIEMLSIPCLA+EASQTFERAV RGAI+A SVA+VLERRLAQRLN +A+F+ +NFQQ D   EG+A+EQLR+QRDDF+ VLGLAETLALSRD CVKGFVKMLY +LFKWYA+E  RGRMLKRLVD ATSTTD++ +VDLDLDIL  L  EEQEI++PVLSMMREVAELANVDRAALWHQLCASEDEIIRMR+E+KAE + M +EKA + QKLS+SEATN RLKSEM+AE+D FAREKKELSEQI EVESQLEW RSERDDEI +L  E+KVLQDRLHDAETQLSQLKSRKRDELK++VKEKNAL ERLK+AE ARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVAR EAYI  MESKLQAC            QQ IHTL ASL+EEM+RHAPLYGAGLEALSM+ELET+S IHEEGLRQIH L  QQRKGSP +SP VSPH L HNHG+YP+ PP MAVG+PP LI NGVGIHSNGH+NG VG
Sbjct:   21 DQSSLATSSSTTTAT---PTSTTTTIDDITVGTTRDGTNGAAAEAVTIDRRGEYSAICKWTVQNFPRVKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLSIFNPLDDSKTIHRDSWHRFSSKKKSHGWCDFTPASTVFDSKLGYLFNNDCVLITADILILNESVSFIRDNSSSTSNNEVQSGVSLSISSNSVVVGPVSDVLSGKFTWKVHNFSLFKEMIKTQKIMSQVFPAGECNLRISVYQSSVNGTDYLSMCLESKDTEKTSV-SDRSCWCLFRMSVLNQKAGGSNHVHRDSYGRFAADNKSGDNTSLGWNDYMKMADFVGAESGFLVDDTAVFSTSFHVIKEFSSFSKNGGLNGGRIGGGARKSDGHMGKFTWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPR----------VFLEVTDSRNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQDFIDQDTESTNSASQIDGVGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGSDPDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLETDAGFLVRDTVVFVCEILDCCPWFEFSDLEVLASEDDQDALTTDPDELIDSDDSEGISGDEEDIFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSNDAKKATKADESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPSEGSSNDDSSDAHPKPSLDGSGAASPLESDRESGATESARFPVHERLDSGLDDSTRASAVQSSD-INGTGIPGQALPGQPIHPPVTTAGGASGNASLRSKTKWPEQSEELLGLIVNSLRALDGAVPQGCPEPRRRPQSAQKIALVLDKAPKHLQPDLVSLVPKLVEHAEHPLVAYALLERLQKPDAEPALRIPVFGALSQLECGSDVWERVLFQSFDLLADSNDEPLAATIDFIFKAASQCQHLPEAVRSVRSRLKILGADVSPFVLDFLSKTVNSWGDVAETILRDIDCDDDLGDSCSTLPCGLFLFGENASAAERLQVVDEQTFHSSSHFSDIYILIEMLSIPCLALEASQTFERAVGRGAIMAQSVAIVLERRLAQRLNFNARFVAENFQQEDAILEGEASEQLRVQRDDFSVVLGLAETLALSRDLCVKGFVKMLYMILFKWYANEPCRGRMLKRLVDHATSTTDNSRDVDLDLDILAILVCEEQEIVKPVLSMMREVAELANVDRAALWHQLCASEDEIIRMRDERKAEISNMAREKANLSQKLSDSEATNNRLKSEMRAEMDRFAREKKELSEQIHEVESQLEWVRSERDDEIIKLTVEKKVLQDRLHDAETQLSQLKSRKRDELKRVVKEKNALTERLKSAEAARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARCEAYIDGMESKLQAC------------QQYIHTLEASLQEEMTRHAPLYGAGLEALSMQELETISRIHEEGLRQIHVL--QQRKGSP-ASPHVSPHTLPHNHGMYPAAPPPMAVGLPP-LISNGVGIHSNGHINGAVG 1677          

Query:  343 EDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRD---SNNNNNELQXXXXXXXXXXXVA-GPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPX-TNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSK-SPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVS-ENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELK----------------------KLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVNGNVGPWFNHS 5283
            +D++V +T     G A E+VT+DRRGEYS  C+WTVQ+FPR+KARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRL+IVN  DDSKTIHRDSWHRFSSKKKSHGWCDFTP+STVFDSKLGYLFN D VLITADILILNESV+F RD   S+ +NNE+Q           VA GPVSDVLSGK TWKV NFSLFKEMIKTQKIMSP               SSVNG +YLSMCLESKDT+KTVV SDRSCWCLFRMSVLNQK   +NH+HRDSYGRFAADNKSGDNTSLGWNDYMKM+DF+G ESGFL+DDTAVFSTSFHVIKEFSSFSKNGGLI GR GSGARK DGHMGKF WRIENF RLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPR          VFLEVTD RNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQ+FTDQDTES+N  SQIDK GKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVG D DKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLE DAGFLV                         ASEDDQDALTTDPDEL+               FRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLD+PAKVK+LLLPTKLSG +DG K  K DESSPSLMNLLMGVKVLQQA        MVECCQP EG+S  D SDA+SK S DGSGAA PL+ DR +GATES+  P  ERL                  + G  +P + LPG+PI PP T+AG + EN +LRSKTKWPEQSEELLGLIVNSLRALDGAV            SAQKIALVLDKAPKHLQ DLV+L+PKLVEH+EHPLAA+AL+ERL+KPDAEPAL  PVFGALSQL+CGS+VWERVL QSF+ L DSNDEPL ATIDFIFKAASQCQHLPEAVRSVR RLKNLG D+SP VL+FLSRTVNSWGDVAETILRDIDCDD  GD+CSTL  GLFLFGE+   +ER H VDEQ F     FSDIYILIEMLSIPCLAVEASQTFERAVARGAI+A SVAMVLERRLAQRLN +A+F+ +NFQ TD   E +A+EQLR+QRDDF+ VLGLAETLALSRD CVKGFVKMLYT+LFKWYA+ETYRGRMLKRLVD ATSTTD++ +VDLDLDIL  L  EEQEI++PVLSMMREVAELANVDRAALWHQLCASEDEIIR+R+E+KAEN+ M +EKA + QKLS+ EATN RLKSEMKAE+D F REKKELSEQIQEVESQLEW RSERDDEI +L  E+KVLQDRLHDAETQLSQLKSRKRDELK                      K+VKEKNALAERLK+AE ARKRFDEELKRYATENVTREEIRQSLEDEVRRLT+TVGQTEGEKREKEEQVAR EAYI  MESKLQAC            QQ IHTL AS+++EM+RHAPLYGAGLEALSM+ELET+S IHEEGLRQIH L  QQ KGSP+SSP VSPH L HNHGLYP+ PP MAVG+PP LIPNGVGIH+NG VNG VGPWFNH+
Sbjct:   10 DDITVGTTLDGTNGAAAETVTIDRRGEYSATCKWTVQSFPRVKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLSIVNPLDDSKTIHRDSWHRFSSKKKSHGWCDFTPASTVFDSKLGYLFNNDCVLITADILILNESVSFMRDNSSSSTSNNEVQSGVSLSISSNSVAVGPVSDVLSGKCTWKVHNFSLFKEMIKTQKIMSPVFPAGECNLRISVYQSSVNGTDYLSMCLESKDTEKTVV-SDRSCWCLFRMSVLNQKAGGSNHVHRDSYGRFAADNKSGDNTSLGWNDYMKMADFIGAESGFLVDDTAVFSTSFHVIKEFSSFSKNGGLIGGRIGSGARKSDGHMGKFTWRIENFMRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPR----------VFLEVTDLRNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQDFTDQDTESTNGTSQIDKVGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGSDPDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLETDAGFLV------------------------LASEDDQDALTTDPDELIDSEDSEGNSGDEEDIFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDEPAKVKKLLLPTKLSGGNDGKKAAKADESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPLEGSSNDDSSDAHSKPSLDGSGAASPLESDRGSGATESAQFPVHERLDSGLDDSKRASAVQSSD-INGTDMPGQALPGQPIYPPVTTAGGALENASLRSKTKWPEQSEELLGLIVNSLRALDGAVPQGCPEPRRRPQSAQKIALVLDKAPKHLQPDLVSLIPKLVEHAEHPLAAYALLERLKKPDAEPALWIPVFGALSQLECGSDVWERVLIQSFDLLADSNDEPLAATIDFIFKAASQCQHLPEAVRSVRTRLKNLGADVSPFVLDFLSRTVNSWGDVAETILRDIDCDDALGDSCSTLPCGLFLFGENASAAERLHVVDEQTFHFRCHFSDIYILIEMLSIPCLAVEASQTFERAVARGAIMAQSVAMVLERRLAQRLNFNARFVNENFQHTDAIIEEEASEQLRVQRDDFSVVLGLAETLALSRDLCVKGFVKMLYTILFKWYANETYRGRMLKRLVDRATSTTDNSCDVDLDLDILAILVCEEQEIVKPVLSMMREVAELANVDRAALWHQLCASEDEIIRIRDERKAENSNMAREKANLSQKLSDCEATNNRLKSEMKAEMDRFTREKKELSEQIQEVESQLEWLRSERDDEITKLTVEKKVLQDRLHDAETQLSQLKSRKRDELKMQLFYCATSDHVAFLWRNVLEIKVVKEKNALAERLKSAEAARKRFDEELKRYATENVTREEIRQSLEDEVRRLTKTVGQTEGEKREKEEQVARCEAYIDGMESKLQAC------------QQYIHTLEASVQDEMTRHAPLYGAGLEALSMQELETISRIHEEGLRQIHAL--QQCKGSPASSPHVSPHTLPHNHGLYPAAPPPMAVGLPP-LIPNGVGIHNNGLVNGTVGPWFNHT 1649          

Query:  265 DHSQPATSSLNSGASEKLPSIPAAAPEDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRD--SNNNNNELQXXXXXXXXXXXVA-GPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPX-TNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSKSPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPP---ETSAGVSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVNGNVGPWFNHS 5283
            D S  ATSS  + A+   P+      +D++V +T     G A E+VT+DRRGEYS +C+WTVQNFPR+KARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRL+I N  DDSKTIHRDSWHRFSSKKKSHGWCDFTP+STVFDSKLGYLFN D VLITADILILNESV+F RD  S+ +NNE+Q           V  GPVSDVLSGKFTWKV NFSLFKEMIKTQKIMS                SSVNG +YLSMCLESKDT+KT V SDRSCWCLFRMSVLNQK   +NH+HRDSYGRFAADNKSGDNTSLGWNDYMKM+DFVG ESGFL+DDTAVFSTSFHVIKEFSSFSKNGGL  GR G GARK DGHMGKF WRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPR          VFLEVTD+RNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQ+F DQDTES+N+ SQID  GKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVG D DKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLE DAGFLVRDTVVFVCEILDCCPWFEFSDLEV ASEDDQDALTTDPDEL+               FRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGS+D  K  K DESSPSLMNLLMGVKVLQQA        MVECCQP+EG          S + D S A                                                P+ +L G     P   +  +G +E+   R  TKWPEQSEELLGLIVNSLRALDGAV            SAQKIALVLDKAPKHLQ DLV+LVPKLVEH+EHPL A+AL+ERLQKPDAEPALR PVFGALSQL+CGS+VWERVL QSF+ L DSNDEPL ATIDFIFKAASQCQHLPEAVRSVR RLK LG D+SP VL+FLS+TVNSWGDVAETILRDIDCDD+ GD+CSTL  GLFLFGE+   +ER   VDEQ F SS  FSDIYILIEMLSIPCLA+EASQTFERAV RGAI+A SVA+VLERRLAQRLN +A+F+ +NFQQ D   EG+A+EQLR+QRDDF+ VLGLAETLALSRD CVKGFVKMLY +LFKWYA+E  RGRMLKRLVD ATSTTD++ +VDLDLDIL  L  EEQEI++PVLSMMREVAELANVDRAALWHQLCASEDEIIRMR+E+KAE + M +EKA + QKLS+SEATN RLKSEM+AE+D FAREKKELSEQI EVESQLEW RSERDDEI +L  E+KVLQDRLHDAETQLSQLKSRKRDELK++VKEKNAL ERLK+AE ARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVAR EAYI  MESKLQAC            QQ IHTL ASL+EEM+RHAPLYGAGLEALSM+ELET+S IHEEGLRQIH L  QQRKGSP +SP VSPH L HNHG+YP+ PP MAVG+PP LI NGVGIHSNGH+NG VGPWFNH+
Sbjct:   21 DQSSLATSSSTTTAT---PTSTTTTIDDITVGTTRDGTNGAAAEAVTIDRRGEYSAICKWTVQNFPRVKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLSIFNPLDDSKTIHRDSWHRFSSKKKSHGWCDFTPASTVFDSKLGYLFNNDCVLITADILILNESVSFIRDNSSSTSNNEVQSGVSLSISSNSVVVGPVSDVLSGKFTWKVHNFSLFKEMIKTQKIMSQVFPAGECNLRISVYQSSVNGTDYLSMCLESKDTEKTSV-SDRSCWCLFRMSVLNQKAGGSNHVHRDSYGRFAADNKSGDNTSLGWNDYMKMADFVGAESGFLVDDTAVFSTSFHVIKEFSSFSKNGGLNGGRIGGGARKSDGHMGKFTWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPR----------VFLEVTDSRNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQDFIDQDTESTNSASQIDGVGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGSDPDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLETDAGFLVRDTVVFVCEILDCCPWFEFSDLEVLASEDDQDALTTDPDELIDSDDSEGISGDEEDIFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSNDAKKATKADESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPSEG----------SSNDDSSDAH-----------------------------------------------PKPSLDGSGAASPLESDRESGATESA--RFPTKWPEQSEELLGLIVNSLRALDGAVPQGCPEPRRRPQSAQKIALVLDKAPKHLQPDLVSLVPKLVEHAEHPLVAYALLERLQKPDAEPALRIPVFGALSQLECGSDVWERVLFQSFDLLADSNDEPLAATIDFIFKAASQCQHLPEAVRSVRSRLKILGADVSPFVLDFLSKTVNSWGDVAETILRDIDCDDDLGDSCSTLPCGLFLFGENASAAERLQVVDEQTFHSSSHFSDIYILIEMLSIPCLALEASQTFERAVGRGAIMAQSVAIVLERRLAQRLNFNARFVAENFQQEDAILEGEASEQLRVQRDDFSVVLGLAETLALSRDLCVKGFVKMLYMILFKWYANEPCRGRMLKRLVDHATSTTDNSRDVDLDLDILAILVCEEQEIVKPVLSMMREVAELANVDRAALWHQLCASEDEIIRMRDERKAEISNMAREKANLSQKLSDSEATNNRLKSEMRAEMDRFAREKKELSEQIHEVESQLEWVRSERDDEIIKLTVEKKVLQDRLHDAETQLSQLKSRKRDELKRVVKEKNALTERLKSAEAARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARCEAYIDGMESKLQAC------------QQYIHTLEASLQEEMTRHAPLYGAGLEALSMQELETISRIHEEGLRQIHVL--QQRKGSP-ASPHVSPHTLPHNHGMYPAAPPPMAVGLPP-LISNGVGIHSNGHINGAVGPWFNHT 1626          

Query:  355 VASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVL-ITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKI---------------MSPSSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSK--------------NGGLITGRSGSG-ARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLE 2319
            ++S  S     A  +V VD   ++ +VC+W + +F +IK+R+L+S+YF+V GYD R L+YPKGDS ++PG+IS+YLQ+ DP    SS  DC+A Y++ IVN+ D++K++ ++S +RFS  +KS GWC+F  S+TV D+  G+L   D VL I+ +I +L+E + F+ D +                      +S  L+GK TW ++N+ L K+M+KTQKI               +S + VNG E LS+ L+ KD +K  V+ DRSCWCLFR+SVL+QKP  +H+ R+ YGRF      G +TSLGW ++MK+SDF   + G+++DD  + S SF+ I+E SSFS               N G + G+S  G  ++ D + GK  W+IENF+RLKD+LKK+K+ GLC+KSRRF+IGN + R++VYPRGQSQ P HLS FLEV D  N+S DWS F+ ++L+V+N +M EKSV K+S  R S A K+ GW EF+TLTSLFDQDSGF+  +T VF+AEV ILKET +  E +D                   S TWK+ENFLSFKEIM +R+I S+FF+ GGC+L+IG+Y+S   IC YL SD      L  NFWV YR+ +VNQ +PAK++ KESS+CTK + N+ LQ MKVSDML+ DAGF+V +T+  VCEILDCCPWFEF + E
Sbjct:   17 ISSPLSETPPAADYTVNVDCSEDFHSVCKWVIPDFRKIKSRSLYSRYFQVSGYDFRFLMYPKGDSLSVPGHISLYLQVNDP---CSSNCDCYACYKIVIVNVVDETKSLSKESVYRFSKNRKSIGWCEFAVSNTVLDANSGFL--KDGVLTISGEIRVLDEKMEFSSDCSEG--------------------MSYALNGKVTWSIRNYGLLKQMVKTQKIISSAFRVWEAYLGVNLSKNMVNGAENLSLFLDIKDIEKNPVI-DRSCWCLFRISVLSQKPGVSHVSREYYGRFGG----GGDTSLGWTEFMKISDFF--DEGYVVDDNVLVSVSFNAIQE-SSFSFRIEGVSSGKCKGMINCGYLGGKSKYGLVKRCDDYTGKIIWKIENFSRLKDILKKKKMKGLCVKSRRFRIGNMEVRILVYPRGQSQKPIHLSTFLEVLDPGNSSGDWSSFIVYQLAVMNGKMIEKSVVKQSAERCSNATKNHGWSEFMTLTSLFDQDSGFIGHETAVFTAEVHILKETFMTTESSD----------------NACSVTWKMENFLSFKEIMLSRRILSRFFEIGGCKLQIGIYQSSANICAYLGSD-----PLIDNFWVNYRITIVNQNDPAKSLCKESSLCTKAYFNADLQLMKVSDMLDTDAGFVVHETITLVCEILDCCPWFEFFEPE 648          

Query: 3457 SQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPI--------SERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSR-KRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQ 4764
            S CQ     V  VR RL+ LG +ISP +L+ L  T+NS  ++AE +LR+ID      + C  L+       +  P         +   H  DE        FSDI+ILI+MLSIP L +EAS  FER VA G I    VA+VLE+  AQR           F     A E   N +     + FT VL LAETL+LS +  V  FVKM Y  LF+ ++ E+Y  RML+ LVDLATS  +++  ++++LD+L+ L   E    RPVL M+ + A+  N D +A+ H+L   E++II + +EK+AE + M  EKA +L++L+E+EA     K  +K        EK+ L+E+++  E+ LE      D ++++ A++  + ++       ++ QLK + ++ E+ K  KE+     R    +   K  D +      EN  REE+ Q
Sbjct:  657 SDCQ-----VNVVRARLELLGAEISPDLLDLLGSTMNSQHEIAEAMLREIDSVFALDEKCKLLDVTPCPLSKEVPYLDSGTRLAANSSHREDESGSHVHHHFSDIFILIDMLSIPSLTIEASGVFERGVAHGYIDNQVVALVLEKH-AQR-----------FSANSTARE--KNAESLFSEEFFTPVLALAETLSLSINSQVHNFVKMFYVTLFEVFSGESYHTRMLRGLVDLATSPVENS--LEMNLDMLIFLVHREHGFARPVLKMVGDAAKHDNADHSAISHRLRCLEEKIIHIGKEKRAELSNMSSEKATLLERLTETEAALLHYKKLLK--------EKEVLAERLRHAEANLE----VSDRKLKKYASKVVIQEEEQQTQLDEIWQLKQKVEQIEIVKQDKEEEVAHYRACTYDLEAKLNDCQKHIQFLENAHREEMEQ 1068          

Query: 4471 LSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSN 5241
            +S +++ +E ++     E+  E+  +++E+  L +RL + E  L   K        KL+KEK  LAERL++AE   +  D +LK+YA++ V +EE +Q+  DE+ +L Q V Q E  K++KEE+VA Y A  Y++E+KL  C            Q+ I  L  + +EEM +HAPLYG GLE+LSM+ LE L  IHE+G++ IH LQ Q R  S S  P             YP     +A G    +IPNGV +H N
Sbjct:  918 ISHRLRCLEEKIIHIGKEKRAELSNMSSEKATLLERLTETEAALLHYK--------KLLKEKEVLAERLRHAEANLEVSDRKLKKYASKVVIQEEEQQTQLDEIWQLKQKVEQIEIVKQDKEEEVAHYRACTYDLEAKLNDC------------QKHIQFLENAHREEMEQHAPLYGVGLESLSMESLENLLRIHEDGIKNIHALQHQLRNRSDSLQPTAQ----------YP-----IADGHSTFVIPNGVHMHKN 1139          

Query:  418 GEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHR 687
            G  S  C+WTVQ+FPR+KARALWSKY EVGGY CRLLIYPKGDSQALPG ISI+LQIMDPRGTSSSKWDCFASYRL+IVN  DDSKT+++
Sbjct:   32 GVCSATCKWTVQSFPRVKARALWSKYLEVGGYGCRLLIYPKGDSQALPGCISIHLQIMDPRGTSSSKWDCFASYRLSIVNPLDDSKTVNQ 121          

Query: 1417 WRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQ--PPCHLSVFLEVTDARNTSSD-WSCFVSHRLSVVNQRMEEKSVTK 1683
            W +++F R+K            + S+  ++G   CRL++YP+G SQ  P C +S+ L++ D R TSS  W CF S+RLS+VN   + K+V +
Sbjct:   40 WTVQSFPRVK---------ARALWSKYLEVGGYGCRLLIYPKGDSQALPGC-ISIHLQIMDPRGTSSSKWDCFASYRLSIVNPLDDSKTVNQ 121          

Query: 1408 KFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILK 1824
            KF W IENFTRL    KK         S  F +G+   R++++P+G +    HLS++L+V D+      WS +    L+VVNQ   + S+ K++Q++++    DWG+  F+ L+ L+D   G+LV DTVV  AEV + K
Sbjct:   53 KFTWTIENFTRLNT--KKHY-------SDVFIVGSYKWRVLIFPKGNNVD--HLSMYLDVADSTTLPYGWSRYAQFSLAVVNQIHNKYSIRKDTQHQFNARESDWGFTSFMPLSELYDPSRGYLVNDTVVIEAEVAVRK 180          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILI 825
            WT++NF R+  +  +S  F VG Y  R+LI+PKG++     ++S+YL + D   T    W  +A + LA+VN   +  +I +D+ H+F++++   G+  F P S ++D   GYL N D+V+I A++ +
Sbjct:   56 WTIENFTRLNTKKHYSDVFIVGSYKWRVLIFPKGNNV---DHLSMYLDVADST-TLPYGWSRYAQFSLAVVNQIHNKYSIRKDTQHQFNARESDWGFTSFMPLSELYDPSRGYLVN-DTVVIEAEVAV 178          

Query: 1408 KFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILK 1824
            KF W IENFTRL     K+  + +      F +G+   R++++P+G +    HLS++L+V D+      WS +    L+VVNQ   + S+ K++Q++++    DWG+  F+ L+ L+D   G+LV DTVV  AEV + K
Sbjct:   53 KFTWTIENFTRLNT---KKHYSDI------FIVGSYKWRVLIFPKGNNVD--HLSMYLDVADSTALPYGWSRYAQFSLAVVNQIHNKYSIRKDTQHQFNARESDWGFTSFMPLSELYDPSRGYLVNDTVVIEAEVAVCK 180          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILI 825
            WT++NF R+  +  +S  F VG Y  R+LI+PKG++     ++S+YL + D        W  +A + LA+VN   +  +I +D+ H+F++++   G+  F P S ++D   GYL N D+V+I A++ +
Sbjct:   56 WTIENFTRLNTKKHYSDIFIVGSYKWRVLIFPKGNNV---DHLSMYLDVADSTALPYG-WSRYAQFSLAVVNQIHNKYSIRKDTQHQFNARESDWGFTSFMPLSELYDPSRGYLVN-DTVVIEAEVAV 178          

Query: 1855 QDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVY---ESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESS--ICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVF-----VCEILD 2286
            Q  ++S   +Q  ++     FTW +ENF      + T+K +S  F  G  + R+ ++    + D + +YL+   S       + + ++ +AVVNQ +   ++ K++      +  +     FM +S++ +   G+LV DTVV      VC++LD
Sbjct:   34 QVEQTSTVENQPVEDPPSMKFTWTIENFTR----LNTKKHYSDIFIVGSYKWRVLIFPKGNNVDHLSMYLDVADSTALPYGWSRYAQFSLAVVNQIHNKYSIRKDTQHQFNARESDWGFTSFMPLSELYDPSRGYLVNDTVVIEAEVAVCKVLD 183          

Query: 1411 FNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRG--QSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVT----KESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVY------ESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQ---KNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEI 2280
            + ++IENF+    LL   KI     +S  F++G+   RL +YP G  ++    H+S++L  +++      W   V+ RL V NQ +++K +T    K    R+     + G+ + + LT   D+  G+L+ D  +F AE+ ++K T   +  T  +   S+            +FTWK++NF      ++     S+ F  GG +  + VY      E   ++ IYL+ +        +  +  Y + V +Q   K+  K  +   S   K W +  L FM + D+     GFLV DT+    +I
Sbjct:   32 YTFKIENFS----LLANAKIDNF--ESGDFEVGSYKWRLRLYPNGNKKNNGDGHISLYLAFSNSNALPFGWEVNVNFRLFVYNQ-IQDKYLTIQYAKGRVRRFHGMKTELGFDQLIPLTIFNDESKGYLIDDRCIFGAEIFVIKPTGKGECLTLVNQPVSD------------TFTWKIQNF----SALDQESYKSQVFSFGGYKWALLVYPKGNSTEKGKSLSIYLKMEDFETLPCGRTTYAEYMLRVKDQLFGKHIEKKAYSHFSYSIKDWGH--LNFMSLDDVNALPKGFLVNDTLAVEVQI 311          

Query: 1117 FRMSVLNQ---KPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQS-QPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFT 1851
            FR+ V NQ   K  T    +    RF      G  T LG++  + ++ F     G+L+DD  +F     VIK            TG+              F W+I+NF+ L              KS+ F  G     L+VYP+G S +    LS++L++ D        + +  + L V +Q +  K + K++ + +S + KDWG   F++L  +     GFLV DT+    ++ ++   ++++EF+
Sbjct:  102 FRLFVYNQIQDKYLTIQYAKGRVRRF-----HGMKTELGFDQLIPLTIFNDESKGYLIDDRCIFGAEIFVIKP-----------TGKGECLTLVNQPVSDTFTWKIQNFSALDQE---------SYKSQVFSFGGYKWALLVYPKGNSTEKGKSLSIYLKMEDFETLPCGRTTYAEYMLRVKDQ-LFGKHIEKKAYSHFSYSIKDWGHLNFMSLDDVNALPKGFLVNDTLAVEVQIHVI---TVVKEFS 321          

Query:  337 APEDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRI---KARALWSKYFEVGGYDCRLLIYPKGDSQAL-PGYISIYLQIMDPRGTSSSKWDCFASYRLAIVN-LADDSKTIH--RDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFS-LFKEMIKTQ----------KIMSPSSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVI---KEFS 1332
            APE +     P RD        T D    + T   + ++NF  +   K     S  FEVG Y  RL +YP G+ +    G+IS+YL   +        W+   ++RL + N + D   TI   +    RF   K   G+    P +   D   GYL + D  +  A+I ++  +                          V  PVSD     FTWK+QNFS L +E  K+Q           ++ P   +  +  S+ +  K  D   +   R+ +  + + V +Q     H+ + +Y  F+   K       G  ++M + D      GFL++DT       HVI   KEFS
Sbjct:    2 APEPVMEVKIPPRDDLAEITRSTRDLPPAHYT---FKIENFSLLANAKIDNFESGDFEVGSYKWRLRLYPNGNKKNNGDGHISLYLAFSNSNALPFG-WEVNVNFRLFVYNQIQDKYLTIQYAKGRVRRFHGMKTELGFDQLIPLTIFNDESKGYLID-DRCIFGAEIFVIKPT------------------GKGECLTLVNQPVSDT----FTWKIQNFSALDQESYKSQVFSFGGYKWALLVYPKGNSTEKGKSLSIYLKMEDFETLPCGRTTYAEYMLRVKDQL-FGKHIEKKAYSHFSYSIK-----DWGHLNFMSLDDVNALPKGFLVNDTLAVEVQIHVITVVKEFS 321          

Query:  265 DHSQPATSSLNSGASEKLPSIPAAAPEDLSVASTPSRDGGGAQESVTVDRRGEYSTVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNNELQXXXXXXXXXXXVAGPVSDVLSGKFTWKVQNFSLFKEMIKTQKIMSP---------------SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPXTNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELVXXXXXXXXXXXXXXXFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAXXXXXXXXMVECCQPTEGTSYGDLSDANSKSPDGSGAACPLQPDRENGATESSDCPACERLXXXXXXXXXXXXXXXXXXVTGIGVPRKTLPGKPICPPETSAGVSENVTLRSKTKWPEQSEELLGLIVNSLRALDGAVXXXXXXXXXXXXSAQKIALVLDKAPKHLQSDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSFEFLRDSNDEPLVATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDISPCVLEFLSRTVNSWGDVAETILRDIDCDDEFGDTCSTLNSGLFLFGEHGPISERFHPVDEQAFRSSRLFSDIYILIEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDAKFIGDNFQQTDVAAEGDANEQLRIQRDDFTSVLGLAETLALSRDPCVKGFVKMLYTLLFKWYADETYRGRMLKRLVDLATSTTDSNHEVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREEKKAENATMVKEKAVILQKLSESEATNTRLKSEMKAEIDCFAREKKELSEQIQEVESQLEWHRSERDDEIRRLATERKVLQDRLHDAETQLSQLKSRKRDELKKLVKEKNALAERLKNAEGARKRFDEELKRYATENVTREEIRQSLEDEVRRLTQTVGQTEGEKREKEEQVARYEAYIYEMESKLQACQTCLINASPYLMQQDIHTLYASLKEEMSRHAPLYGAGLEALSMKELETLSGIHEEGLRQIHTLQQQQRKGSPSSSPLVSPHALQHNHGLYPSTPPQMAVGMPPSLIPNGVGIHSNGHVNGNVGPWFNHS 5283
            D SQPATSS NSGAS+KLPSIPAAAPEDL+V S   RDGGGAQESVTVDRRGEYS VCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNN               VAGPVSDVLSGKFTWKV NFSLFKEMIKTQKIMSP               SSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKP +NHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVG ESGFL+DDTAVFSTSFHVIKEFSSFSKNGGLI GRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTD+RNTSSDWSCFVSHRLSVVNQR+EEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQ+ TDQDTESSN+GSQ+DKN KRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVG DLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDEL+               FRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQA        MVECCQPTE +S GDLSD N KSPDGSGAA PLQ DRENGA ES  CP  ERL                  + G G+P K  PG PI PPETSAG SENV+LRSKTKWPEQSEELLGLIVNSLRALDGAV            SAQKI+LVLDKAPKHLQ DLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQS EFL DSNDEPL ATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVD+SPCVLEFLSRTVNSWGDVAETILRDIDCDD+ GD+CSTL+SGLFLFGEHGP SERFH VDEQAFR+SR FSDIYIL+EMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDA+F+ DNFQQ D   EG+ANEQLR+QRDDFTSVLGLAETLALSRD CVKGFVKMLYTLLFKWYADE+YRGRMLKRLVD ATSTTDS+ EVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREE+KAENA MV+EKAVI QKLSESEAT  RLKSEMKA+ID FAREKKELSEQIQEVESQLEWHRSERDDEIR+L T+RKVLQDRLHDAE+Q+SQLKSRKRDELKK+VKEKNALAERLK+AE ARKRFDEELKRYATEN+TREEIRQSLEDEVR+LTQTVGQTEGEKREKEEQVAR EAYI  MESKLQAC            QQ IHTL ASL+EEMSRHAPLYGAGLEALSMKELETLS IHEEGLRQIHTL QQQRK SP+ SPLVSPHALQHNHGLYP+TPPQMAVG+PPSLIPNGVGIHSNGHVNG VGPWFNHS
Sbjct:   28 DQSQPATSSPNSGASDKLPSIPAAAPEDLAVGS---RDGGGAQESVTVDRRGEYSAVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNELQSSAGSMMMSGSVVAGPVSDVLSGKFTWKVHNFSLFKEMIKTQKIMSPVFPAGECNLRISVYQSSVNGVEYLSMCLESKDTDKTVVLSDRSCWCLFRMSVLNQKPGSNHMHRDSYGRFAADNKSGDNTSLGWNDYMKMSDFVGLESGFLVDDTAVFSTSFHVIKEFSSFSKNGGLIAGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDSRNTSSDWSCFVSHRLSVVNQRLEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQDLTDQDTESSNSGSQMDKNAKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDTICIYLESDQSVGSDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEILDCCPWFEFSDLEVFASEDDQDALTTDPDELIDSEDSEGIGGDEEDIFRNLLSRAGFHLTYGDNPSQPQVTLREKLLMDAGAIAGFLTGLRVYLDDPAKVKRLLLPTKLSGSSDGMKVIKNDESSPSLMNLLMGVKVLQQAIIDLLLDIMVECCQPTEASSNGDLSDTNLKSPDGSGAASPLQSDRENGAAESVHCPVYERLDTSVDETSSSASAVQSSDMNGTGIPGKPHPGHPISPPETSAGGSENVSLRSKTKWPEQSEELLGLIVNSLRALDGAVPQGCPEPRRRPQSAQKISLVLDKAPKHLQPDLVALVPKLVEHSEHPLAAFALIERLQKPDAEPALRTPVFGALSQLDCGSEVWERVLSQSLEFLSDSNDEPLAATIDFIFKAASQCQHLPEAVRSVRVRLKNLGVDVSPCVLEFLSRTVNSWGDVAETILRDIDCDDDMGDSCSTLHSGLFLFGEHGPSSERFHSVDEQAFRASRHFSDIYILVEMLSIPCLAVEASQTFERAVARGAIVAHSVAMVLERRLAQRLNLDARFVADNFQQPDAVVEGEANEQLRVQRDDFTSVLGLAETLALSRDLCVKGFVKMLYTLLFKWYADESYRGRMLKRLVDRATSTTDSSREVDLDLDILVTLASEEQEIIRPVLSMMREVAELANVDRAALWHQLCASEDEIIRMREERKAENANMVREKAVISQKLSESEATINRLKSEMKADIDRFAREKKELSEQIQEVESQLEWHRSERDDEIRKLTTDRKVLQDRLHDAESQISQLKSRKRDELKKVVKEKNALAERLKSAEAARKRFDEELKRYATENITREEIRQSLEDEVRQLTQTVGQTEGEKREKEEQVARCEAYIDGMESKLQAC------------QQYIHTLEASLQEEMSRHAPLYGAGLEALSMKELETLSRIHEEGLRQIHTL-QQQRKSSPAGSPLVSPHALQHNHGLYPATPPQMAVGLPPSLIPNGVGIHSNGHVNGAVGPWFNHS 1699          

Query: 1411 FNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILK-ETSIMQEFTDQDTESSNA---GSQIDKNGKRSSF-----------TWKVENFLSFKEIMETRKIF 1977
            F W IENF++LK+           + S  F IG+   R++++P+G +     LSV+LEV DA +    W+ +    L+VVNQ    KS+TK+S++ ++ +  DWG+  F+ L+ L D ++GFL  D  +  A+V + K +  I++   DQ T SS A     Q D+  + SS            T   +  ++F++   +R++F
Sbjct:   14 FTWTIENFSKLKNQK---------LYSEVFLIGDWKWRILIFPKGNNVK--QLSVYLEVVDASDLPFLWTRYAEFSLTVVNQLNSNKSITKDSKHGFNSSESDWGFTSFMALSELCDSNNGFLRNDKCIIEADVSVRKVDIKILE---DQGTGSSAAIEPSEQEDQGQEPSSVDSVQVPHSSVTTPSSQQVVAFQDAPSSRQVF 203          

Query:  418 GEY-STVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNN 873
            GE+ S    WT++NF ++K + L+S+ F +G +  R+LI+PKG++      +S+YL+++D        W  +A + L +VN  + +K+I +DS H F+S +   G+  F   S + DS  G+L N D  +I AD+ +    +    D    ++
Sbjct:    7 GEFVSETFTWTIENFSKLKNQKLYSEVFLIGDWKWRILIFPKGNNVK---QLSVYLEVVDASDLPFL-WTRYAEFSLTVVNQLNSNKSITKDSKHGFNSSESDWGFTSFMALSELCDSNNGFLRN-DKCIIEADVSVRKVDIKILEDQGTGSS 154          

Query: 1411 FNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILK-ETSIMQEFTDQDTESSNA---GSQIDKNGKRSSF-----------TWKVENFLSFKEIMETRKIF 1977
            F W IENF++LK+           + S  F IG+   R++++P+G +     LSV+LEV DA +    W+ +    L+VVNQ    KS+TK+S++ ++ +  DWG+  F+ L+ L D ++GFL  D  +  A+V + K +  I++   DQ T SS A     Q D+  + SS            T   +  ++F++   +R++F
Sbjct:   14 FTWTIENFSKLKNQK---------LYSEVFLIGDWKWRILIFPKGNNVK--QLSVYLEVVDASDLPFLWTRYAEFSLTVVNQLNSNKSITKDSKHGFNSSESDWGFTSFMALSELCDSNNGFLRNDKCIIEADVSVRKVDIKILE---DQGTGSSAAIEPSEQEDQGQEPSSVDSVQVPHSSVTTPSSQQVVAFQDAPSSRQVF 203          

Query:  418 GEY-STVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDSNNNNN 873
            GE+ S    WT++NF ++K + L+S+ F +G +  R+LI+PKG++      +S+YL+++D        W  +A + L +VN  + +K+I +DS H F+S +   G+  F   S + DS  G+L N D  +I AD+ +    +    D    ++
Sbjct:    7 GEFVSETFTWTIENFSKLKNQKLYSEVFLIGDWKWRILIFPKGNNVK---QLSVYLEVVDASDLPFL-WTRYAEFSLTVVNQLNSNKSITKDSKHGFNSSESDWGFTSFMALSELCDSNNGFLRN-DKCIIEADVSVRKVDIKILEDQGTGSS 154          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILI 825
            WT++NF R+  +  +S  F VGGY  R+LI+PKG++     Y+S+YL + D  GT    W  +A + LA+VN      +I +D+ H+F++++   G+  F P   ++D   GYL N D+V++ A++ +
Sbjct:   50 WTIENFARLNTKKHYSDMFIVGGYKWRILIFPKGNNV---DYLSMYLDVADS-GTLPYGWSRYAHFSLAVVNQIQTKYSIRKDTQHQFNARESDWGFTSFMPLGDLYDPSRGYLVN-DTVVVEAEVAV 172          

Query: 1408 KFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILK 1824
            KF W IENF RL    KK         S  F +G    R++++P+G +    +LS++L+V D+      WS +    L+VVNQ   + S+ K++Q++++    DWG+  F+ L  L+D   G+LV DTVV  AEV + K
Sbjct:   47 KFTWTIENFARLNT--KKHY-------SDMFIVGGYKWRILIFPKGNNVD--YLSMYLDVADSGTLPYGWSRYAHFSLAVVNQIQTKYSIRKDTQHQFNARESDWGFTSFMPLGDLYDPSRGYLVNDTVVVEAEVAVRK 174          

Query: 1393 DGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLI 1818
            D    +F WRI+NF+R+    KK       + S  F +G    R++++P+G +    HLS++L+V D+ +    WS +    L +VNQ   + SV K++Q++++    DWG+  F+ L+ L+D   G+LV DT++  AEVL+
Sbjct:   51 DPPSSRFTWRIDNFSRMNT--KK-------LYSDIFVVGGYKWRVLIFPKGNNVD--HLSMYLDVADSASLPYGWSRYAQFCLGLVNQIHNKYSVRKDTQHQFNARESDWGFTSFMPLSDLYDPSRGYLVNDTLIIEAEVLV 181          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDS 858
            W + NF R+  + L+S  F VGGY  R+LI+PKG++     ++S+YL + D        W  +A + L +VN   +  ++ +D+ H+F++++   G+  F P S ++D   GYL N D+++I A++L+      +T DS
Sbjct:   59 WRIDNFSRMNTKKLYSDIFVVGGYKWRVLIFPKGNNV---DHLSMYLDVADSASLPYG-WSRYAQFCLGLVNQIHNKYSVRKDTQHQFNARESDWGFTSFMPLSDLYDPSRGYLVN-DTLIIEAEVLVRRVVDYWTYDS 192          

Query: 1843 EFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVY---ESFDTICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESS--ICTKTWNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEIL 2283
            E   Q   ++N  +Q  ++   S FTW+++NF      M T+K++S  F  GG + R+ ++    + D + +YL+   S       + + ++ + +VNQ +   +V K++      +  +     FM +SD+ +   G+LV DT++   E+L
Sbjct:   33 EVVAQPETANNVENQPVEDPPSSRFTWRIDNFSR----MNTKKLYSDIFVVGGYKWRVLIFPKGNNVDHLSMYLDVADSASLPYGWSRYAQFCLGLVNQIHNKYSVRKDTQHQFNARESDWGFTSFMPLSDLYDPSRGYLVNDTLIIEAEVL 180          

Query: 1405 GKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNG----KRSSFTWKVENFLSFKEIMETRKIFSKFF 1989
            G F WRI+NF+ L        +         F +G    R++++P+G +    +LSV+L+  +A    S  + +   RL++VNQ   +KS+TK++++ +    KDWG+  F+ L+ L D D G+LV D  V   EV +     I++   DQ+T     G  ID  G    +++   +  E   S+  ++E  K  S+ F
Sbjct:   12 GTFTWRIDNFSTLNKQTHYSDV---------FVVGGYKWRILIFPKGNNVD--YLSVYLDFAEASTLPSGSTRYAKFRLTLVNQVDSKKSITKDTEHEFVANEKDWGFTSFILLSELCDHDKGYLVNDFCVVEVEVSVRNGIKILE---DQET-----GELIDFRGLGRVEKTFVPFLEEVCSSYPSLLECHKKRSRTF 191          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILN 831
            W + NF  +  +  +S  F VGGY  R+LI+PKG++     Y+S+YL   +   T  S    +A +RL +VN  D  K+I +D+ H F + +K  G+  F   S + D   GYL N D  ++  ++ + N
Sbjct:   16 WRIDNFSTLNKQTHYSDVFVVGGYKWRILIFPKGNNV---DYLSVYLDFAEA-STLPSGSTRYAKFRLTLVNQVDSKKSITKDTEHEFVANEKDWGFTSFILLSELCDHDKGYLVN-DFCVVEVEVSVRN 140          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILNESVNFTRDS 858
            WT+++F R+  + L+S  F VGGY  R+LI+PKG++     ++S+YL + D  GT    W  +A + L+IVN      +I +++ H+F++++   G+  F P   ++D   GY+ N D+ ++ AD+ +      ++ DS
Sbjct:   41 WTIESFSRLNTKKLYSDIFLVGGYKWRILIFPKGNN---VDHLSMYLDVAD-SGTLPYGWSRYAQFSLSIVNQIHSKYSIRKETQHQFNARESDWGFTSFMPLGELYDPGRGYIVN-DTCIVEADVAVRRVIDYWSHDS 174          

Query: 1408 KFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLI 1818
            +F W IE+F+RL    KK       + S  F +G    R++++P+G +    HLS++L+V D+      WS +    LS+VNQ   + S+ KE+Q++++    DWG+  F+ L  L+D   G++V DT +  A+V +
Sbjct:   38 RFTWTIESFSRLNT--KK-------LYSDIFLVGGYKWRILIFPKGNNVD--HLSMYLDVADSGTLPYGWSRYAQFSLSIVNQIHSKYSIRKETQHQFNARESDWGFTSFMPLGELYDPGRGYIVNDTCIVEADVAV 163          

Query: 1411 FNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCH--LSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLI 1818
            F W IE F+ LK   +K    G       F +G+   +++VYP+G S  P    LS++L V +A    S WS +    L+VVNQ   +KS+T E+++ +S++  DWG+  F+ L+ L D   GFLV D  V  AEV +
Sbjct:   14 FTWTIEKFSTLKS--QKHYSEG-------FSVGDFQWQMVVYPKGSSGIPGKHDLSIYLNVANASALPSGWSRYAQFTLTVVNQVDRDKSITVETKHVFSESKSDWGFTSFMPLSELCDCTRGFLVNDICVLEAEVAV 142          

Query:  427 STVCRWTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGY--ISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILI 825
            S    WT++ F  +K++  +S+ F VG +  ++++YPKG S  +PG   +SIYL + +     S  W  +A + L +VN  D  K+I  ++ H FS  K   G+  F P S + D   G+L N D  ++ A++ +
Sbjct:   11 SVTFTWTIEKFSTLKSQKHYSEGFSVGDFQWQMVVYPKGSS-GIPGKHDLSIYLNVANASALPSG-WSRYAQFTLTVVNQVDRDKSITVETKHVFSESKSDWGFTSFMPLSELCDCTRGFLVN-DICVLEAEVAV 142          

Query: 1405 GKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPCHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNG----KRSSFTWKVENFLSFKEIMETRKIFSKFF 1989
            G F WRI NF+ L +L     +  +C             R+I+YP+G +    +LS++L+V DA    S W+ +    L+VVNQ   +KS+T++ ++ ++    +WG + F+ L+ L D + G+LV D  V   +V +     I++   DQ+T     G  ID  G    +++   +  E   S+  ++E  K  S+ F
Sbjct:   14 GTFTWRINNFSTLNNLAHYSDVFVIC---------GYKWRIIIYPKGNNVD--YLSLYLDVADASTLRSGWTRYAKFSLTVVNQLDSKKSITRDLEHEFAANDSNWGIKSFILLSELRDHNKGYLVNDLCVVEVKVSVRNGIKILE---DQET-----GELIDFRGLGRVEKTFVPFLEEVCSSYPSLLECHKKRSRPF 193          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILILN 831
            W + NF  +   A +S  F + GY  R++IYPKG++     Y+S+YL + D   T  S W  +A + L +VN  D  K+I RD  H F++   + G   F   S + D   GYL N D  ++   + + N
Sbjct:   18 WRINNFSTLNNLAHYSDVFVICGYKWRIIIYPKGNNV---DYLSLYLDVADA-STLRSGWTRYAKFSLTVVNQLDSKKSITRDLEHEFAANDSNWGIKSFILLSELRDHNKGYLVN-DLCVVEVKVSVRN 142          

Query: 1411 FNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPPC--HLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNR---YSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLILKETSIMQEFTDQDTESSNAGSQIDKNGKRSSFTWKVENFLSFKEIMETRKIFSKFFQAGGCELRIGVYESFDT------ICIYLESDQSVGCDLDKNFWVRYRMAVVNQKNPAKTVWKESSICTKT------WNNSVLQFMKVSDMLEADAGFLVRDTVVFVCEI 2280
            +  +IE+F+ LK     R       +S  F  G    +L+VYP G  +     H+SV+LE+  A +  + W  FV  RL +++Q      V +++  +      A  + G+   + L +  D  +G+L+ DT VF AEV + KE              +     + +      + WK+E F   K       + SK F AGG   +I +Y   D+      + + L                ++ + +V+Q N AK  ++++S C +       W+N    F+ +    E D G+LV +T V   E+
Sbjct:   13 YTLKIESFSLLKKHSADR------FESGEFDAGGYKWKLVVYPNGYKKKNVEDHISVYLEMAGAESLETGWEVFVDFRLFLLDQNKGIYLVLQDANLKKMCLHVAMLEVGFDRVIPLKAFADASNGYLIDDTCVFGAEVFVCKE------------RRAGKAECLPRINNAVIYVWKIEEFSKLK----PEPLESKPFNAGGQTWKIQLYPKGDSHGNHTHVSLSLTLANPEKLSTASKILAQFTLRIVDQLN-AKHFFRQASNCFRASSPSWGWSN----FIMLGFFKERDKGYLVMNTCVVEAEV 292          

Query: 1219 LGWNDYMKMSDFVGTESGFLLDDTAVFSTSFHVIKEFSSFSKNGGLITGRSGSGARKLDGHMGKFNWRIENFTRLKDLLKKRKITGLCIKSRRFQIGNRDCRLIVYPRGQSQPP-CHLSVFLEVTDARNTSSDWSCFVSHRLSVVNQRMEEKSVTKESQNRYSKAAKDWGWREFVTLTSLFDQDSGFLVQDTVVFSAEVLI 1818
            +G++  + +  F    +G+L+DDT VF     V KE  +         G++    R  +  +  + W+IE F++LK            ++S+ F  G +  ++ +YP+G S     H+S+ L + +    S+         L +V+Q +  K   +++ N +  ++  WGW  F+ L    ++D G+LV +T V  AEV +
Sbjct:  115 VGFDRVIPLKAFADASNGYLIDDTCVFGAEVFVCKERRA---------GKAECLPRINNAVI--YVWKIEEFSKLKPEP---------LESKPFNAGGQTWKIQLYPKGDSHGNHTHVSLSLTLANPEKLSTASKILAQFTLRIVDQ-LNAKHFFRQASNCFRASSPSWGWSNFIMLGFFKERDKGYLVMNTCVVEAEVTV 294          

Query:  442 WTVQNFPRIKARALWSKYFEVGGYDCRLLIYPKGDSQALPGYISIYLQIMDPRGTSSSKWDCFASYRLAIVNLADDSKTIHRDSWHRFSSKKKSHGWCDFTPSSTVFDSKLGYLFNTDSVLITADILI 825
            W ++ F ++K   L SK F  GG   ++ +YPKGDS     ++S+ L + +P   S++     A + L IV+   ++K   R + + F +   S GW +F       +   GYL   ++ ++ A++ +
Sbjct:  170 WKIEEFSKLKPEPLESKPFNAGGQTWKIQLYPKGDSHGNHTHVSLSLTLANPEKLSTAS-KILAQFTLRIVDQL-NAKHFFRQASNCFRASSPSWGWSNFIMLGFFKERDKGYLV-MNTCVVEAEVTV 294