MDP0000281707, MDP0000281707 (mRNA) Malus spp. (apple)

Query:   40 EKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQ----KLFTLPEPTSNSS-----------------------VLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSEL 1194
            EKDPTGRY+RYDE+LG+GAFKTVYKAFDEV+G+EVAW QV+I+ V    +++ERLYSEVHLLKSLKH+NI++F+NSWVDDKN TINMITEL TSG+LRQYR KHK VDMKAIKNWARQILRGL YLH+ +P IIHRDLKCDN+ VNG NGE+KIGDLGLAIVMQQP A S+IGTPEFMAPELY+EEYNELVDIYSFGMCMLEMV CEYPYSECKN AQIYK VTSG+KPASL KV++ Q+K+FIEKCLVPAS+RLSA +LLKDP LAT+N  E    LSQL     K   LP+  S+                          LEL  F++NNEFRLRA KN DNTVSLTLRIAD CG  RNI F FYL+SDT +SIA EMVEQLDLS EDV+V+AEL D+ IVKLVP W  SS +
Sbjct:   16 EKDPTGRYVRYDEILGKGAFKTVYKAFDEVDGIEVAWNQVDIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYNSWVDDKNKTINMITELLTSGNLRQYRKKHKTVDMKAIKNWARQILRGLQYLHTRSPRIIHRDLKCDNILVNGNNGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVTSGIKPASLVKVNDLQVKEFIEKCLVPASVRLSAIDLLKDPFLATENSKEVVSSLSQLPNVICKQVHLPQSESHHMDIDCKMLSLGSCPKSINESPQFLTLELRRFTENNEFRLRAEKNDDNTVSLTLRIADPCGRARNIHFTFYLNSDTAVSIAEEMVEQLDLSSEDVAVIAELIDSLIVKLVPCWNTSSSV 431          

Query:    1 MDSCSGLEDAGVV--EKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLP---------------------------EPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPS 1185
            MD  S  ED G V  EKDPTGRY+R DE LG+GAFKTVYKAFDEV+G+EVAW QVNI+ V    +++ERLYSEVHLLKSLKH+NI++F++SWVDDKN TIN+ITELFTSGS+RQYR KHK VDMKAIKNWARQILRGL YLH+H+PPIIHRDLKCDN+FVNG  GE+KIGDLGLAIVMQQP A S+IGTPEFMAPELY+EEYNELVDIYSFGMCMLEMV CEYPYSECKN AQIYK V+SG+KPASL KV + Q+K FIEKCLVPAS RL A ELLKDP LAT+N  E      QL  L +                               +   S LEL  F++NNEFRLR  KN DNTVSLTLRIAD CG  RNI F FYLDSDT + IA EMVEQLDL  EDV+V+AEL DN I KLVP W  S
Sbjct:    1 MDFGSLSEDGGGVFAEKDPTGRYIRNDEFLGKGAFKTVYKAFDEVDGIEVAWNQVNIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYSSWVDDKNKTINIITELFTSGSMRQYRKKHKTVDMKAIKNWARQILRGLHYLHTHSPPIIHRDLKCDNIFVNGNTGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVSSGIKPASLGKVSDHQVKVFIEKCLVPASTRLPAIELLKDPFLATENSKELVSSSLQLPNLISRQVHLLQSESHLMDIDCKKLSVGSCTKSINESPQFSTLELSRFTENNEFRLRGAKNNDNTVSLTLRIADPCGRARNIHFTFYLDSDTAVLIAEEMVEQLDLLTEDVAVIAELIDNLIAKLVPSWNTS 428          

Query:   22 EDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLPEPTSNS---SVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSELSL 1200
            +D+   EKDPTGRY+RY+E LG+GAFKTVYKAFDEV+G+EVAW QV I+ +    +++ERLYSEVHLLKSLKH NI++F+NSWVDD N TIN+ITELFTSGSLRQYR KHK VD+KAIKNWA+QILRGL YLHSHNPPIIHRDLKCDN+FVNG NGE+KIGDLGLAIVMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMC+LE+V CEYPY+ECKN AQIYK V+SG+KPASL KV +PQ+KQFIEKCLVPAS+RLSA ELLKD   AT+N  E    +S  + + T  +  S +     L+   F+KNN F+LR  K  DN++S+TL IAD CG  +NI F FYLDSDT +SIA EMVEQLDL +EDV+V+AEL D  I +LVP WKP+ E  L
Sbjct:  148 DDSDFEEKDPTGRYVRYNEFLGKGAFKTVYKAFDEVDGIEVAWGQVEIEDLLQSPQQLERLYSEVHLLKSLKHDNIIKFYNSWVDDTNKTINLITELFTSGSLRQYRKKHKNVDLKAIKNWAKQILRGLHYLHSHNPPIIHRDLKCDNIFVNGNNGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCEYPYNECKNPAQIYKKVSSGIKPASLGKVSDPQVKQFIEKCLVPASLRLSAQELLKDAFFATENSKE-PLSVSTHKSMSTHMKSISGTPHFRALQFERFNKNNLFKLRGEKIDDNSISMTLHIADPCGRAKNIHFAFYLDSDTALSIAGEMVEQLDLYNEDVAVIAELIDVMISELVPTWKPAFESML 546          

Query:   13 SGLEDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDN------------------LNESSCDLSQLQ----KLFTLP--------EPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSELSLADKDRYDALK 1230
            S ++D GVVEKDPT RY RYDE+LG+GAFKTVYKAFDEV+G+EVAW Q++I+ V    + +E+LYSEVHLLKSLKH+NI++ ++SWVD+K+  INMITELFTSGSLRQYR KHK VDMKAIKNWARQILRGL +LHSHNPP+IHRDLKCDN+FVNG NG++KIGDLGLAIVMQQPTA S+IGTPEFMAPELY+EEYNELVD+YSFGMC+LEM+ CEYPYSECKN AQIYK VTSG+KPASL++V++P++KQFIEKCLVPASMRL A+ELLKDP LAT N                  LN  +C+   ++       T P        E +  SS  ++   ++NNEFRLR  KN D T+SLTLRIAD  G  RNI F FY+DSDT ISIA EMVE L+L  EDV+V+AEL  N I KLVP WKP  E S    + Y  L+
Sbjct:    3 SEIDDVGVVEKDPTLRYARYDEMLGKGAFKTVYKAFDEVDGIEVAWNQISIEDVMQSPQNLEKLYSEVHLLKSLKHENIIKMYSSWVDEKSSNINMITELFTSGSLRQYRKKHKNVDMKAIKNWARQILRGLCFLHSHNPPVIHRDLKCDNIFVNGNNGQVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDVYSFGMCILEMITCEYPYSECKNPAQIYKKVTSGIKPASLARVNDPEVKQFIEKCLVPASMRLPASELLKDPFLATGNTKEIYHDNLLLPNPPSKSLNPPTCEPHPMEIDSNVKHTSPASTVERDKETSQVSSNHDILRKTENNEFRLRGEKNADRTISLTLRIADANGGARNIHFPFYIDSDTTISIAEEMVEHLELKDEDVAVIAELIHNMIFKLVPDWKPLCENSSGTDNLYRPLE 442          

Query:    1 MDSCS-GLEDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNES-----------------------SCDLSQLQKLFTLPEPTSNS------SVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSELS 1197
            MD CS   +D+   EKDPTGRY+RYDEVLG+GAFKTVYKAFDE+ G+EVAW QV+++ V    +++ERLYSEVHLLKSLKH+NI++F+NSWVDD N TINMITELFTSGSLR+YR KHK VD+KAIKNWARQILRGL YLHSHNPPIIHRDLKCDN+FVNG NGE+KIGDLGLA VMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMC+LEMV CEYPYSECKN AQIYK VTSG+KPASL KV++P +K+FIEKC+VPASMRL A ELLKDP LAT+N  E                          D+    K  ++   T +       S  E    +  NEFRLR  KN DNT+SLTLRI D CG V+NI F FYLDSDT +SIA EMVEQLDLS+EDV+++AEL D  I+KLVP    S   S
Sbjct:    1 MDFCSRDDDDSEFEEKDPTGRYVRYDEVLGKGAFKTVYKAFDEINGIEVAWNQVSVEDVLQSPDQLERLYSEVHLLKSLKHENIMKFYNSWVDDNNKTINMITELFTSGSLRKYRKKHKNVDIKAIKNWARQILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILEMVTCEYPYSECKNPAQIYKKVTSGIKPASLCKVNDPLVKRFIEKCIVPASMRLPALELLKDPFLATENPKELVFASLHLPDLMLKQVSRGQSESYPMDIDSNHKKLSVGSCTKSMDESLHFSTSEFQRLTVKNEFRLRGEKNDDNTISLTLRIVDRCGGVKNIHFTFYLDSDTTLSIAEEMVEQLDLSNEDVAIIAELIDALILKLVPHLSQSGSTS 433          

Query:   22 EDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDN----------LNESSCDLSQLQKLFTLPEP-------------------------TSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSELSL 1200
            +D+   EKDPTGRY+RY+E LG+GAFKTVYKAFDEV+G+EVAW QV I+ +    +++ERLYSEVHLLKSLKH NI++F+NSWVDD N TIN+ITELFTSGSLRQYR KHK VD+KAIKNWA+QILRGL YLHSHNPPIIHRDLKCDN+FVNG NGE+KIGDLGLAIVMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMC+LE+V CEYPY+ECKN AQIYK V+SG+KPASL KV +PQ+KQFIEKCLVPAS+RLSA ELLKD   AT+N          +++S    + +  L  LP+P                         T +   L+   F+KNN F+LR  K  DN++S+TL IAD CG  +NI F FYLDSDT +SIA EMVEQLDL +EDV+V+AEL D  I +LVP WKP+ E  L
Sbjct:    9 DDSDFEEKDPTGRYVRYNEFLGKGAFKTVYKAFDEVDGIEVAWGQVEIEDLLQSPQQLERLYSEVHLLKSLKHDNIIKFYNSWVDDTNKTINLITELFTSGSLRQYRKKHKNVDLKAIKNWAKQILRGLHYLHSHNPPIIHRDLKCDNIFVNGNNGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCEYPYNECKNPAQIYKKVSSGIKPASLGKVSDPQVKQFIEKCLVPASLRLSAQELLKDAFFATENSKEPVYNHMHVDDSLQSSNFMPNLMNLPKPELQPMDMDPNYKKLSVSTHMKSISGTPHFRALQFERFNKNNLFKLRGEKIDDNSISMTLHIADPCGRAKNIHFAFYLDSDTALSIAGEMVEQLDLYNEDVAVIAELIDVMISELVPTWKPAFESML 440          

Query:   34 VVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQL----QKLFTLP-------------------------EPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSE 1191
            VVEKD T RY RYDE+LG+GAFKTVYKAFDEV+G+EVAW  ++++ V    +++E+LYSE+HLLKSLKH N+++ +NSWVDD   TINMITELFTSGSLRQYRNKHK VDMKAIKNWARQILRGL +LH H+PPI+HRDLKCDN+FVNG +G +KIGDLGLAIVMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMC+LEMV CEYPYSEC N AQIYK VTSG+KPA+L+KV++P++KQFIEKCLVPASMRLSA+ELLKDP LAT+N  E + D+ +L     KL   P                         E TS  S  +L   ++NN+F LR  KN ++T+SLTLRIA+ CG  RNI F FY++SDT ISIA EMVE L+L++EDVSV+AEL ++ I KLVP  KP SE
Sbjct:    6 VVEKDLTSRYARYDELLGKGAFKTVYKAFDEVDGIEVAWNMISVEDVVQTPQQLEKLYSEIHLLKSLKHDNVIKLYNSWVDDTTGTINMITELFTSGSLRQYRNKHKNVDMKAIKNWARQILRGLCFLHCHSPPIVHRDLKCDNIFVNGNSGLVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILEMVTCEYPYSECNNPAQIYKKVTSGIKPAALAKVNDPEVKQFIEKCLVPASMRLSASELLKDPFLATENTKEINHDILELPNPHTKLVNPPTCEPHPMEIDSKSRRTSPGSSMGRIEETSQVSFFDLVRMTENNKFMLRGEKNAESTISLTLRIANACGGARNIHFPFYINSDTAISIAEEMVEHLELTNEDVSVIAELINDMIAKLVPNLKPLSE 424          

Query:   34 VVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQ----KLFTLP-------------------------EPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSE 1191
            VVEKDPT RY RYDE+LG+GAFKTVYKAFDEV+G+EVAW ++ ++ V    +++ +LYSEVHLLKSLKH N+++ +NSWVDD   TINMITELFTSGSLRQYR KHK VDMKAIKNWARQILRGL +LHS +PPI+HRDLKCDN+FVNG +G +KIGDLGLAIVMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMC+LEMV CEYPYSECKN AQIYK VTSG+KPA+L+KV++P++KQFIEKCLVPASMRLSA+ELLKDP LAT+N  E + D  QL     KL  LP                         E TS  S  +L   + NN+  LR  KN ++T+SLTLRI D CG  RNI F FY+DSDT ISIA EMVE L+L++EDVSV+AEL ++ I KLVP  KP  E
Sbjct:    6 VVEKDPTSRYARYDELLGKGAFKTVYKAFDEVDGIEVAWNRIGVEDVVQTPQQLGKLYSEVHLLKSLKHDNVIKLYNSWVDDTAGTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARQILRGLCFLHSQSPPIVHRDLKCDNIFVNGNSGLVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILEMVTCEYPYSECKNPAQIYKKVTSGIKPAALAKVNDPEVKQFIEKCLVPASMRLSASELLKDPFLATENTKEINHDTLQLPNPHIKLVNLPKCEPHPMEIDSYSRRTSPGSSMGRIEETSQVSFFDLVRMTDNNKLMLRGEKNAESTISLTLRIPDACGGARNIHFPFYMDSDTAISIAEEMVEHLELTNEDVSVIAELINDMIAKLVPNSKPLCE 424          

Query:   28 AGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATD-NLNESSCDLSQLQKLF----TLPEP-------------------------TSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWK 1179
            A +VEKDPTGRY+RYD+VLG+GAFKTVY+AFDEV+G+EVAW QV I  V    E+ E+LYSEV+LL+SL+H+NI++F NSWVDDKN TINMITELFTSG+LRQYR KH+ +D+KAIKNWARQILRGL YLH H+PPIIHRDLKCDN+FVNG +GE+KIGDLGLAIVMQ PTA S+IGTPEFMAPELY+EEYNELVDIYSFGMC+LE+V C YPYSEC+N AQIYK VTSG+KPASL  V N QIK+FIEKCL+PAS RLSA ELLK P L  +  + E  CD   +   F    +LP+                          +  S VLE     KNNEF L+  KN DN+ SLTLRI+D  G VRNI F FYLDSDT IS+A EMVEQL+L+  DV+ +AEL D+ IVKL+PGWK
Sbjct:    8 ADLVEKDPTGRYVRYDDVLGKGAFKTVYRAFDEVDGIEVAWNQVRIDDVLRSPEDFEKLYSEVYLLRSLRHENIIKFSNSWVDDKNKTINMITELFTSGNLRQYRRKHRNIDIKAIKNWARQILRGLVYLHGHSPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQNPTAKSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCNYPYSECRNAAQIYKKVTSGIKPASLKTVGNTQIKEFIEKCLLPASERLSAKELLKHPFLQLEIPILEQICDPLPVPDQFPISLSLPKSGPLFMDMDIDEKQLSESTCTGSNNGSPKSPVLEYQRAHKNNEFGLKGMKNDDNSASLTLRISDLGGRVRNIHFIFYLDSDTAISVASEMVEQLELADHDVAFIAELIDSLIVKLLPGWK 425          

Query:    1 MDSCSGLEDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLPEPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKP 1182
            M      ++A  VEKDPTGRY+R+ E+LG+GAFKTVYKAFDEV+G+E+AW QV I  V    E++E+LYSEVHLLKSLKH+NI++F+NSWVDDK  T+NMITELFTSGSLRQYR KHK VDMKAIKNWARQ+LRGL YLHSHNPPIIHRDLKCDN+FVNG +GE+KIGDLGLAIVMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMCMLEMV  EYPY+ECKN AQIYK VTSG+KPASL KV + QIK+FI KCL PAS RL A ELLKDP   ++N  E             +P    +  VLE     K++EFRLRA K  DN++SLTLR  D+ G V+NI F F LD+DTV S+  EMVEQL+L+  +V+ +A+  D  I++L+PGWKP
Sbjct:    9 MQGAEDEDEAAYVEKDPTGRYVRFKEILGKGAFKTVYKAFDEVDGIEIAWNQVKIDDVLRSPEDLEKLYSEVHLLKSLKHENIIKFYNSWVDDKKKTVNMITELFTSGSLRQYRKKHKNVDMKAIKNWARQVLRGLVYLHSHNPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYNECKNPAQIYKKVTSGIKPASLCKVTDLQIKEFIVKCLAPASERLPAKELLKDPFFQSENPKEP----------IRVP-LHPDFPVLEFQRMYKSSEFRLRAKKINDNSISLTLRTVDSYGPVKNIHFPFSLDTDTVHSVVGEMVEQLELAEHEVAFIADFIDYVIMRLLPGWKP 395          

Query:   22 EDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLPEPTSNS---SVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSELSL 1200
            +D+   EKDPTGRY+RY+E LG+GAFKTVYKAFDEV+G+EVAW QV I+ +    +++ERLYSEVHLLKSLKH NI++F+NSWVDD N TIN+ITELFTSGSLRQYR KHK VD+KAIKNWA+QILRGL YLHSHNPPIIHRDLKCDN+FVNG NGE+KIGDLGLAIVMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMC+LE+V CEYPY+ECKN AQIYK V+SG+KPASL KV +PQ+KQFIEKCLVPAS+RLSA ELLKD   AT+N  E    +S  + + T  +  S +     L+   F+KNN F+LR  K  DN++S+TL IAD CG  +NI F FYLDSDT +SIA EMVEQLDL +EDV+V+AEL D  I +LVP WKP+ E  L
Sbjct:  148 DDSDFEEKDPTGRYVRYNEFLGKGAFKTVYKAFDEVDGIEVAWGQVEIEDLLQSPQQLERLYSEVHLLKSLKHDNIIKFYNSWVDDTNKTINLITELFTSGSLRQYRKKHKNVDLKAIKNWAKQILRGLHYLHSHNPPIIHRDLKCDNIFVNGNNGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCEYPYNECKNPAQIYKKVSSGIKPASLGKVSDPQVKQFIEKCLVPASLRLSAQELLKDAFFATENSKE-PLSVSTHKSMSTHMKSISGTPHFRALQFERFNKNNLFKLRGEKIDDNSISMTLHIADPCGRAKNIHFAFYLDSDTALSIAGEMVEQLDLYNEDVAVIAELIDVMISELVPTWKPAFESML 546          

Query:    1 MDSCSGLEDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLPEPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKP 1182
            M      ++A  VEKDPTGRY+R+ E+LG+GAFKTVYKAFDEV+G+E+AW QV I  V    E++E+LYSEVHLLKSLKH+NI++F+NSWVDDK  T+NMITELFTSGSLRQYR KHK VDMKAIKNWARQ+LRGL YLHSHNPPIIHRDLKCDN+FVNG +GE+KIGDLGLAIVMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMCMLEMV  EYPY+ECKN AQIYK VTSG+KPASL KV + QIK+FI KCL PAS RL A ELLKDP   ++N  E             +P    +  VLE     K++EFRLRA K  DN++SLTLR  D+ G V+NI F F LD+DTV S+  EMVEQL+L+  +V+ +A+  D  I++L+PGWKP
Sbjct:    9 MQGAEDEDEAAYVEKDPTGRYVRFKEILGKGAFKTVYKAFDEVDGIEIAWNQVKIDDVLRSPEDLEKLYSEVHLLKSLKHENIIKFYNSWVDDKKKTVNMITELFTSGSLRQYRKKHKNVDMKAIKNWARQVLRGLVYLHSHNPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYNECKNPAQIYKKVTSGIKPASLCKVTDLQIKEFIVKCLAPASERLPAKELLKDPFFQSENPKEP----------IRVP-LHPDFPVLEFQRMYKSSEFRLRAKKINDNSISLTLRTVDSYGPVKNIHFPFSLDTDTVHSVVGEMVEQLELAEHEVAFIADFIDYVIMRLLPGWKP 395          

Query:   25 DAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNES-SCDLSQLQKLFTLPEPTSN----SSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKP 1182
            D  V+E DPT RY+R+ ++LG+GAFKTVYKAFD+V+G+EVAW QV I  V    +E+ERLYSEVHLLKSLKH+NI++F+NSW+DD N T+N+ITELFTSGSLRQYR KHKKVDMKA+K WARQIL GL+YLH+HNPPIIHRDLKCDN+F+NG  GE+KIGDLGLA VMQQ  A ++IGTPEFMAPELYDE YNEL DIYSFGMCMLEMV  EYPYSEC+N AQIYK V++G+KPA+LSK+ + ++K FIEKCLVPAS RLSA +LL DP    D L ++    L  +  + T  + + +    S  +E+      N F L+   N +N++SL LRIAD  G +RNI F FYLDSDT +S++ EMVEQL+L+ ++V+ +AEL D  ++ L+P WKP
Sbjct:   20 DPDVLEIDPTSRYIRFKDILGKGAFKTVYKAFDQVDGIEVAWNQVRIDEVLQSPDELERLYSEVHLLKSLKHKNIIKFYNSWIDDGNKTVNIITELFTSGSLRQYRKKHKKVDMKAVKGWARQILMGLNYLHNHNPPIIHRDLKCDNIFINGNQGEVKIGDLGLATVMQQANARTVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTLEYPYSECRNSAQIYKKVSNGIKPAALSKIKDLEVKMFIEKCLVPASQRLSAKKLLNDPFFQVDGLTKNHPLQLPDILPIITSMDNSVDGGPYSLCMEVQRAKGGNFFLLKGEGNDENSISLILRIADQNGRLRNIHFMFYLDSDTALSVSSEMVEQLELADQNVTFIAELIDLLLIMLIPTWKP 414          

Query:   25 DAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNI----KGVEEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQP-TAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLPEP----------TSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSEL 1194
            D   VE DPTGRY RY EVLG+GAFK VY+AFDE+EG+EVAW QV +    +  EE ERLYSEVHLLK+LKH+NI++F+ SWVD +N  IN ITE+FTSG+LRQYR KHK VD++A+K W+RQIL GL YLHSH+PP+IHRDLKCDN+FVNG  GE+KIGDLGLA +++Q  +AHS+IGTPEFMAPELY+EEYNELVDIY+FGMC+LE+V  EYPY EC N AQIYK VTSG+KPASL+KV +P+++ FI+KC+   S RLSA ELL+DP L +D  N S     Q       P P          T  SS + L   S+  +F+++  +   NT+ L LRIAD+ G +RNI F F + +DT IS+A EMVE+LDL+ +DVS +A + D+ I  ++  W PS E+
Sbjct:   15 DTEFVEIDPTGRYGRYKEVLGKGAFKKVYRAFDELEGIEVAWNQVKVADLLRNSEEFERLYSEVHLLKTLKHKNIIKFYISWVDTRNENINFITEIFTSGTLRQYRKKHKHVDLRALKKWSRQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCLLELVTFEYPYVECANAAQIYKKVTSGIKPASLAKVKDPRVRAFIDKCIANVSDRLSAKELLRDPFLQSDEENGSVGRSLQ-------PHPHHSGSHDHFNTGTSSKVSLPESSR--DFKVQGQRRDVNTIFLKLRIADSKGHIRNIHFPFDIGADTAISVAGEMVEELDLTDQDVSTIAAMIDSEIRSIISDWPPSREV 410          

Query:   37 VEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNI----KGVEEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLN------ESSCDLSQLQKLFTLPEPTSNSSVLELXXFS----------KNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSELSLADKDRYDA 1224
            VE DPTGRY RY+E+LG+GA KTVY+AFDE EG+EVAW QV +    +  EE+ERLY E+HLLK+LKH NI++F+ SWVD  N  IN +TE+FTSG+LRQYR KH++V+++A+K+W RQILRGL YLH+H PP+IHRDLKCDN+FVNG  GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+EEYNELVDIYSFGMC+LEMV  EYPYSEC + AQIYK V SG KP +L KV +P+++QF+EKCL   ++RLSA ELLKDP L +D+        E   DL ++  L  LP    +    E               +N +  +   K  D+ + L LRI+D  G VRNI F F +++DT +S+A EMV +LD++ +DV+ +A++ D+ I  LVPGWK    +  +    +DA
Sbjct:   15 VEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLNDFLQSPEELERLYCEIHLLKTLKHNNIMKFYTSWVDPANRNINFVTEMFTSGTLRQYRLKHRRVNIRAVKHWCRQILRGLLYLHNHKPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVRQFVEKCLATVTLRLSARELLKDPFLQSDDYGSDLRPIEYQRDLGEVGPLPRLPHYGIHHIEFERNEIDLFTYQEDEHLENVDISIEGRKRDDHGIFLRLRISDKEGRVRNIYFPFDMETDTALSVAMEMVSELDITDQDVTKIADMIDDEIASLVPGWKMGLGIEESQNYGHDA 430          

Query:   37 VEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNI----KGVEEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLPEPTSNSSVLELXXFSK-----NNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKP 1182
            VE DPTGRY RY+E+LG+GA KTVY+AFDE EG+EVAW QV +    +  E++ERLY E+HLLK++KH NI++F+ SWVD  N  IN +TE+FTSG+LRQYR KHK+V+++A+K+W RQILRGL YLHSH+PP+IHRDLKCDN+FVNG  GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+EEYNELVDIYSFGMC+LEMV  EYPYSEC + AQIYK V SG KP +L KV +P++++F+EKCL   S+RLSA ELL+DP L  D+       +   ++   + EPT     +EL  + +     N +  ++  +  D+ + L LRIAD    +RNI F F ++ DT +S+A EMV +LD++ +DV+ +A++ D  I  LVP WKP
Sbjct:   16 VEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTMKHNNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRQKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVREFVEKCLASVSLRLSARELLQDPFLRIDDCESDLRPIECRREPDDMMEPTG----IELFEYHEDEHPANVDISIKGKRREDDGIFLRLRIADKEDHIRNIYFPFDIEMDTALSVATEMVAELDITDQDVTKIADMIDGEIASLVPEWKP 402          

Query:   16 GLEDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQ-QPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLPEPTSNSSVLELXXFSKN---NEFRLRAGKNP-DNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWK 1179
            G +++G  E DPTGRY R DEVLG+GA KTVYKA DEV G+EVAW QV +  V    +E++RLYSEVHLL +L H +I+QF+ SW+D +  T N ITE FTSG+LR+YR K+K+VD++AIK WARQILRGL YLH H+PP+IHRDLKCDN+FVNG  GE+KIGDLGLA +++   +AHS+IGTPEFMAPELY+E YNELVD+YSFGMC+LEM+  EYPYSEC N AQIYK VTSG  P +  ++ + + ++FI KCLV AS RL A ELL DP LA+D            QK      P  N   +E    S +       +    NP D+T+ L ++ AD  G  RNI F F + +DT I +A EMV++L+++  +   +A++ D  I  LVP WK
Sbjct:   13 GKDESGYAETDPTGRYGRLDEVLGKGAMKTVYKAIDEVLGMEVAWNQVKLNEVLRSPDELQRLYSEVHLLSALNHDSIIQFYTSWIDVERKTFNFITEFFTSGTLREYRKKYKRVDIRAIKCWARQILRGLVYLHGHDPPVIHRDLKCDNIFVNGHLGEVKIGDLGLAAILRGSQSAHSVIGTPEFMAPELYEENYNELVDVYSFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPGAFYRIQDLEAQRFIGKCLVTASKRLPAKELLLDPFLASDEAKRLPKPKLGSQK------PFLNDIRIEKLRLSDDRVRTNMTITGTLNPDDDTIFLKVQTADKDGSARNIYFPFDIVTDTPIDVAMEMVKELEITDWEPFEIADMIDGEISALVPQWK 403          

Query:   31 GVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQ-QPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLPEPTSNSSVLELXXFSKN-----NEFRLRAGKNPDN-TVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWK 1179
            G VE DP+GRY R+ E+LG+GA KTVYKAFDE  G+EVAW QV +  V    ++++RLYSEVHLLK+L H +I++FH SW+D    T N I+E+FTSG+LR+YR K+K+VD+ A+KNWARQIL GL YLH H+PP+IHRDLKCDN+FVNG  G++KIGDLGLA +++    AHS+IGTPEFMAPELY+EEY+ELVD+YSFGMC+LEM+  EYPY EC N AQIYK VTSG  P +  ++++ + ++F+ +CL   + RL A ELL DP LA D+  E    + ++       +P+ N +V ++  F  N      +  +    NPD+ T+ L + I+D  GL RNI F F + SDT I +A EMV +L+++  +   +A++ +  I  LVP WK
Sbjct:   18 GYVETDPSGRYGRFREILGKGAMKTVYKAFDEFLGMEVAWNQVKLNDVFNSPDDLQRLYSEVHLLKNLDHDSIMRFHTSWIDLDGGTFNFISEMFTSGTLREYRQKYKRVDIGAVKNWARQILHGLAYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQHAHSVIGTPEFMAPELYEEEYDELVDVYSFGMCVLEMLTSEYPYCECSNPAQIYKKVTSGKLPEAFYRIEDVEAREFVGRCLEHVAKRLPAKELLMDPFLAVDH-GEQMLPMLKISS----QKPSPNGTVEKIPSFQTNPRKRSTDMTITGTINPDDYTIFLKVAISDKDGLSRNIYFPFDIGSDTPIDVAAEMVRELEITDWEPFEIAKMIEEEIFALVPSWK 406          

Query:   37 VEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGVEE----VERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLA-IVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDN 837
            VE DPTGRY RY ++LG GA K VY+AFD+ EG+EVAW QV ++   E    V+RL+SEV LL +LK+++I+  ++ W D+++ T+N ITE+ TSG+LR YR +H+ V +KA+K W+RQ+L+GL+YLH+H+P IIHRDL C N+F+NG  G++KIGDLGLA IV +   AHS++GTPE+MAPELY+E+Y E+VDIYSFGMC+LEMV  E PYSEC N+A+IYK VTSGV P +++KV +P++K FIEKC+     R SA+ELL DP  +  N
Sbjct:  547 VEVDPTGRYGRYSDLLGHGAVKKVYRAFDQEEGIEVAWNQVQLRNFSEDKSMVDRLHSEVKLLSTLKNESIIVLYSVWKDNEHNTLNFITEVCTSGNLRDYRKRHRHVSIKALKKWSRQVLKGLEYLHTHDPCIIHRDLNCSNIFINGNIGQVKIGDLGLAAIVGKNHLAHSVLGTPEYMAPELYEEDYTEMVDIYSFGMCLLEMVTMEIPYSECDNIAKIYKKVTSGVGPLAMNKVSDPEVKFFIEKCIAQPRARPSASELLNDPFFSELN 818          

Query:   37 VEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGVEE----VERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGL-AIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDP 819
            VE DPT RY RY+E+LG GA K VY+AFD+ EG+EVAW QV ++   +    ++RL+SEV LLK+LK +NI+  +N W ++ + T+N ITE+ TSG+LR+YR KH+ V MKA+K W++QIL+GLDYLH H P IIHRDL C N+F+NG  G++KIGD GL A V +   AHS++GTPEFMAPELY+E+Y ELVDIYSFGMC LEMV  E PYSEC N+A+IYK V SG +P ++ KV +P++K FIEKCL     R SA+ELL DP
Sbjct:   17 VEVDPTRRYGRYNELLGCGAVKRVYRAFDQEEGIEVAWNQVKLRAFSDDKPMIDRLFSEVRLLKTLKDKNIIALYNVWRNEDHNTLNFITEVCTSGNLREYRKKHRHVSMKALKKWSKQILKGLDYLHRHEPCIIHRDLNCSNVFINGNVGKVKIGDFGLAATVGKSHVAHSVLGTPEFMAPELYEEDYTELVDIYSFGMCFLEMVTLEIPYSECDNIAKIYKKVISGARPRAMDKVRDPEVKAFIEKCLAKPRARPSASELLNDP 282          

Query:   13 SGLEDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGVEEV----ERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLS-----------QLQKLFTLPEPTSNSSV-----------LELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLV 1167
            S +E+A   EKDP+GRY+RYD+VLGRGAFKTVYKAFDEV+G+EVAW  V+I+ V ++    ERLYSEVHLLK+LKH+NI++   SWVD+KN TINMITELFTSGSLR YR KH+KVD KAIKNWARQIL+GL+YLHS NPP+IHRDLKCDN+FVNG  GE+KIGDLGLA V+QQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMCMLEMV CEYPY+EC+N AQIYK VTS +KP SL KVD+PQ++QFIEKCL+PAS R +A EL KDP LA D   +S+   S           QL+ L    +   N SV           +EL   ++N EFRLR  ++ D T S+ LRIAD  G  R + F FYL+SDT  +IA EMVE+L L+ ++V V+A++ D+ I++L+
Sbjct:   12 SSMEEADFAEKDPSGRYIRYDDVLGRGAFKTVYKAFDEVDGIEVAWNLVSIEDVMQMPGQLERLYSEVHLLKALKHENIIKLFYSWVDEKNKTINMITELFTSGSLRVYRKKHRKVDPKAIKNWARQILKGLNYLHSQNPPVIHRDLKCDNIFVNGNTGEVKIGDLGLATVLQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYNECRNQAQIYKKVTSNIKPQSLGKVDDPQVRQFIEKCLLPASSRPTALELSKDPFLARDGGKDSALLASSSTSSKYVRPPQLEHLPMDVDHNENKSVSSNEDYPWSQTIELQRIAENKEFRLRGERSDDVTASMVLRIADPSGKCRIVHFAFYLESDTATAIAEEMVEELHLTSQEVVVIADMIDDFIMQLL 422          

Query:   19 LEDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDN-----------------------------LNESSCDLSQLQKLFTLPEPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPG 1173
            ++DA  VE DPT RY+RY+EVLGRGA KTVYKAFDEVEG+EVAW QV I  V    + +ERLYSEVHLLKSLKH+N+++F+N WVDD+  TIN+ITELFTSGSLRQYR KH +VD+KAIKNWARQ+LRGLDYLH+H PPIIHRDLKCDN+FVNG +GE+KIGDLGLA VM  P A S+IGTPEFMAPELYDE Y+ELVDIYSFGMCMLEM   EYPYSEC N AQI+K V+ GVKPA+L+K+ N Q KQFI+KCLVPAS RLSA ELL+DP L +DN                              NES C  +   K   L  P  + SVLE    +KN E +L   K  DN+VSL LRIAD CG  RNI F FYLDSDT +S+A EMVEQL+L+  DV+ +A+  D  IV LVPG
Sbjct:   10 VDDAECVEVDPTRRYIRYNEVLGRGAMKTVYKAFDEVEGIEVAWSQVEIDEVMQSPDNLERLYSEVHLLKSLKHENVMKFYNYWVDDQKKTINVITELFTSGSLRQYRQKHPRVDLKAIKNWARQVLRGLDYLHTHQPPIIHRDLKCDNIFVNGNHGEVKIGDLGLATVMLTPRAKSVIGTPEFMAPELYDENYDELVDIYSFGMCMLEMFTLEYPYSECTNAAQIFKKVSKGVKPAALAKITNIQAKQFIDKCLVPASERLSAKELLQDPFLCSDNSSVLVGTKFPSSLPKSVDVSLEALHMDVDTNESMC--TSTCKRNDLGGP--HRSVLEFTRTNKNTELKLTGEKLDDNSVSLVLRIADLCGHARNIHFLFYLDSDTAMSVAAEMVEQLELADCDVTFIADFIDLLIVNLVPG 423          

Query:   19 LEDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLPEPT-----------SNSSV-----------------LELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGW---KPSSELSLADKDRYDALKRELDAIGKQYFSKLREEE 1284
            +E+A  V+KDPTGRY+RY++VLGRGAFKTVYKAFDEVEG+EVAW  ++I+ V     +++RLYSEVHLL SLKH NI++   SWVDD N +INMITELFTSGSL  YR KH+KVD KAI NWARQIL+GL YLHS  PP+IHRDLKCDN+FVNG  G++KIGDLGLA VMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMCMLEMV CEYPY EC+N AQIYK VTSG+KP SLSKVD+PQ+KQFIEKCL+PA  R +A ELLKD +LA D   +S+   S          P             N+SV                 +E+   +++ EF+L   +  D   S+ LRIA + G  R + FDF L +DT  ++  EMVE+LDLS  +V+V+AE+ D  I+KL         +S     D++  +++K E+ A    Y+ ++   E
Sbjct:    1 MEEADFVQKDPTGRYIRYNDVLGRGAFKTVYKAFDEVEGIEVAWNLMSIEDVLQMPGQLDRLYSEVHLLNSLKHDNIIKLFYSWVDDHNKSINMITELFTSGSLTLYRKKHRKVDPKAIMNWARQILKGLHYLHSQTPPVIHRDLKCDNIFVNGNTGKVKIGDLGLAAVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYRECRNQAQIYKKVTSGIKPQSLSKVDDPQVKQFIEKCLLPAPSRPTALELLKDQLLAVDGAKDSTLTASSNTTFKPAMPPQCEYRPMDVEYKKNTSVSICSSAKSSQECALLQTMEVQRVAESTEFKLSGERRDDVAASMALRIAGSSGQARKVDFDFNLKTDTARAVTGEMVEELDLSSHEVTVIAEMIDELIMKLKANRSLPNANSVYQSKDEEAGESMKSEISA---DYYHRVSSNE 454          

Query:    4 DSCSGLE---DAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGVEE----VERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESS------------------CDLSQ--------------LQKLFTLPEPT----SNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWK 1179
            D  S L+   D  V+E DPT RY+RY EV+G+GAFKTVYKAFDEV+G+EVAW QV I  V +    +ERLYSEV LLKSLKH NI++F+NSW+DDKN T+N+ITELFTSGSLR YR KH+KV+MKA+KNWARQIL GL YLH   PPIIHRDLKCDN+F+NG +GE+KIGDLGLA VM+Q  A S+IGTPEFMAPELYDE YNEL DIYSFGMCMLEMV  +YPY ECKN AQIYK V+SG+KPASLS+V +P++KQFIEKCL+PAS RLSA ELL DP L  + L  ++                  C +S+              L +   LP  T    S S  +E+    + N F L+  +N + +VSL LRI D  G VRNI F FY + DT   ++ EMVEQL+L+ ++V+ +AEL D  +V ++P WK
Sbjct:    5 DDASALQEPPDPEVLEVDPTFRYIRYKEVIGKGAFKTVYKAFDEVDGIEVAWNQVRIDDVLQSPNCLERLYSEVRLLKSLKHNNIIRFYNSWIDDKNKTVNIITELFTSGSLRHYRKKHRKVNMKAVKNWARQILMGLRYLHGQEPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFDYPYCECKNSAQIYKKVSSGIKPASLSRVKDPEVKQFIEKCLLPASERLSAKELLLDPFLQLNGLTMNNPLPLPDIVMPKEGAFGDRCLMSEGPPTTRPSKTLSIDLDEDSNLPIVTFSDNSGSRCIEVRRAKRGNFFVLKGEENDEQSVSLILRIVDENGRVRNIHFLFYQEGDTASKVSSEMVEQLELTDQNVTFIAELIDILLVNMIPTWK 439          

Query:   25 DAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGVEE----VERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNL----------------------------------NESSCDLSQLQKL-FTLPEPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWK 1179
            D  V+E DPT RY+RY EV+G+GA KTV+K FDEV+G+EVAW QV I  + +    +ERLYSEV LLKSLKH+NI++F+NSW+DDKN T+N+ITELFTSGSLRQYR KH+KV+MKA+K WARQIL GL YLHS +PPIIHRD+KCDN+F+NG +GE+KIGDLGLA VM+Q  A S+IGTPEFMAPELYDE YNEL DIYSFGMCMLEMV  EYPY EC+N AQIYK V+SG+KPASLSKV +P++ +FIEKCL+PAS RLSA ELL D  L  + L                                     S +L +   L   +    S ++ +E+    + N F L+  +N +N+VSL LRI D  G VRNI F F+ + DT  +++ EMVEQL+L+ ++V  +AEL D  +V L+P WK
Sbjct:   15 DPEVLEIDPTCRYIRYKEVIGKGASKTVFKGFDEVDGIEVAWNQVRIDDLLQSPDCLERLYSEVRLLKSLKHKNIIRFYNSWIDDKNKTVNIITELFTSGSLRQYRKKHRKVNMKAVKCWARQILTGLKYLHSQDPPIIHRDIKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFEYPYCECRNSAQIYKKVSSGIKPASLSKVKDPEVMKFIEKCLLPASERLSAEELLLDSFLNVNGLVMNNPLPLPDIVMPKEGSFGERCLMSEGPPNARNRTMSMNLDEDNNLPIVISSNNSGTNCIEVRRAKRGNFFVLKGEENDENSVSLILRIVDENGRVRNIHFLFFQEGDTASNVSSEMVEQLELTDKNVKFIAELIDVLLVNLIPNWK 438          

Query:   37 VEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIK----GVEEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQP-TAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLPEPTSN-SSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLS-HEDVSVVAELXDNSIVKLVPGWKPS 1185
            VE DPTGRY RY EVLG+GAFK VY+AFD++EG+EVAW QV +       E+++RLYSEVHLLK+LKH++I++F+ SW+D ++MTIN+ITE+FTSG+LRQYR KHK VD++A+K W+RQIL GL YLHSH+PP+IHRDLKCDN+F+NG  GE+KIGDLGLA ++ +  +AHS+IGTPEFMAPELY+E+YN LVDIY+FGMC+LE+V  EYPYSEC N AQIY+ VTSG+KPA+L  V +PQ++ FIEKC+   S RLSA ELL DP L         C     + + +  E   N + +++    S+     +   +   NT+ L LRI D+ G +RNI F F +++DT  S+A EMVE+LDL+  +D+S +A++ D  I   +P W PS
Sbjct:   13 VEIDPTGRYGRYKEVLGKGAFKEVYRAFDQLEGIEVAWNQVKLDDKFCSSEDLDRLYSEVHLLKTLKHKSIIKFYTSWIDHQHMTINLITEVFTSGNLRQYRKKHKCVDLRALKKWSRQILEGLVYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILHRARSAHSVIGTPEFMAPELYEEDYNVLVDIYAFGMCLLELVTFEYPYSECTNAAQIYRKVTSGIKPAALLNVTDPQVRAFIEKCIAKVSQRLSAKELLDDPFL--------KCYKENTENVSSHKENGYNGNGIVDKLSDSEVGLLTVEGQRKDLNTIFLKLRITDSKGQIRNIHFPFNIETDTSFSVAIEMVEELDLTDDQDISTIAKMIDTEIHSHIPDWTPS 394          

Query:   40 EKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQP-TAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATD--------NLNESSCD---LSQLQKLFTLPEPTSNSSVLE-LXXFSKN--NEFRLRAGKNPD----------------NTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGW 1176
            E DPT RY RY EVLG+GAFKTVYKAFD++EG+EVAW Q+ +  +    +++ERL SEV LLK+LKH+NI++F+NSW+D KN  IN ITE+FTSG+LRQYR KHKKVD++A+K W+RQIL GL YLHSH+PP+IHRDLKCDN+FVNG  GE+KIGDLGLA ++    +AHSIIGTPEFMAPELYDEEYNELVDIY+FGMC+LE+V  EYPY EC N AQIYK V+ G KP+SL+K+++P+++ FIEKC+  AS RLSA ELL DP L  D          N  + D    S     +      S+ ++ E    F++   ++  + +  +P                 NT+ L LRIAD+ G  +NI F F +++DT IS+A EMV QLDL+ +DV+ +AE+ D  I   +P W
Sbjct:   20 EVDPTARYGRYTEVLGKGAFKTVYKAFDQLEGLEVAWNQIKVGDILRNNDDLERLRSEVRLLKTLKHKNIIKFYNSWLDKKNNNINFITEVFTSGTLRQYRIKHKKVDVRALKKWSRQILSGLVYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLATILDNARSAHSIIGTPEFMAPELYDEEYNELVDIYAFGMCLLELVTFEYPYCECSNAAQIYKKVSDGEKPSSLAKIEDPEVRFFIEKCIAKASQRLSAQELLMDPFLRDDGEKIFYPLQSNTKASDGAGSSNSSMGYKYDRDASSMAIREHTGSFAEEHPSDRYIHSTMDPQAAAGRIITVESQMKDLNTIFLKLRIADSTGHAQNIHFPFDIEADTSISVATEMVVQLDLTDQDVTAIAEMIDAEIRAHIPDW 433          

Query:   13 SGLEDAGV-VEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLN------------ESSCDLSQLQKLFTLP---EPTSNSSVLELXXFSKNNE----FRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSELS 1197
            S +ED  V VE DP+GRY RYDE+LG+GA KTVY+AFDE EG+EVAW QV ++      EE+E+ + E+HLLK+L HQNI++F+ SWVD  N++IN +TELFTSG+LRQYR +H++V+++A+K W +QIL+GL YLHS +PPIIHRDLKCDN+F+NG  GE+KIGDLGLA ++++  A   +GTPEFMAPE+YDEEYNELVD+Y+FGMC+LEMV  +YPYSEC + AQIYK VTSG KP +   V +P++++F+EKCL   + RL+A ELL+DP L  DN++                 +     L   P   +   +S + E+  F+ ++E      ++  +N D+ + L LRI+D  G +RNI F F    DT  S+A EMV +LD++++DV+ +AE+ D  I  LVP WK  +E S
Sbjct:    6 SFVEDCSVFVEIDPSGRYGRYDEILGKGASKTVYRAFDEYEGIEVAWNQVKLRNFTRNPEELEKFFREIHLLKTLNHQNIMKFYTSWVDTNNLSINFVTELFTSGTLRQYRLRHRRVNIRAVKQWCKQILKGLLYLHSRSPPIIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAVRCVGTPEFMAPEVYDEEYNELVDVYAFGMCVLEMVTFDYPYSECTHPAQIYKKVTSGKKPEAFYLVKDPEVREFVEKCLANVTCRLTALELLQDPFLQDDNMDGFVMRPIDYYNGYDETGVFLRHPLIDDPLYHDQFESSQICEIDLFANDDEDHVDISIKGKRNGDDGIFLRLRISDAEGRIRNIYFPFETAIDTAWSVAVEMVSELDITNQDVAKIAEMIDAEIAALVPDWKNDTESS 424          

Query:   40 EKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNI----KGVEEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNL----NESSCDLSQLQKLFTLPEPTSNSSVLE----------------------------LXXFS-------KNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSELSLADKDRY 1218
            E DPTGRY RY++VLG+GA KTVY+AFDE +G+EVAW QV +    +  E++ERLY E+HLLK+LKH+NI++F+ SWVD     IN ITE+FTSG+LRQYR KH +V++ A+K+W RQIL GL YLHSH+PPIIHRDLKCDN+FVNG  GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+EEYNELVDIYSFGMC+LEMV  EYPYSEC +  QIYK V SG KP +L KV +P ++QF+EKCL  AS RLSA ELLKDP L  D+L     +    L    +   L    SN S++                             +  F+        N +  ++  K+ D ++ L LRIAD  G VRNI F F +++DT +S+A EMV +LD++  +V+ +AE+ D  +  LVP W+P   +  +    Y
Sbjct:   19 EVDPTGRYGRYNDVLGKGASKTVYRAFDEYQGMEVAWNQVKLHDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDVSRRNINFITEMFTSGTLRQYRQKHMRVNIWAVKHWCRQILSGLLYLHSHDPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAVHCVGTPEFMAPEVYEEEYNELVDIYSFGMCVLEMVTFEYPYSECTHPVQIYKKVISGTKPEALYKVKDPMVRQFVEKCLATASRRLSARELLKDPFLQVDDLVFCPGDGDYSLMNYLRQPYLEHAYSNVSMMSNGLSESIDEDTPTEDRWDCEDDDIKADGIDLFNGHEDEPLGNVDITIKGRKSEDGSIFLRLRIADNDGHVRNIYFPFDIEADTALSVATEMVAELDITDHEVTRIAEMIDGEVSALVPDWRPGPGIEESQDTTY 454          

Query:   40 EKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNI----KGVEEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNL----NESSCDLSQLQKLFTLPEPTSNSSVLE----------------------------LXXFS-------KNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSELSLADKDRY 1218
            E DPTGRY RY++VLG+GA KTVY+AFDE +G+EVAW QV +    +  E++ERLY E+HLLK+LKH+NI++F+ SWVD     IN ITE+FTSG+LRQYR KH +V++ A+K+W RQIL GL YLHSH+PPIIHRDLKCDN+FVNG  GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+EEYNELVDIYSFGMC+LEMV  EYPYSEC +  QIYK V SG KP +L KV +P ++QF+EKCL  AS RLSA ELLKDP L  D+L     +    L    +   L    SN S++                             +  F+        N +  ++  K+ D ++ L LRIAD  G VRNI F F +++DT +S+A EMV +LD++  +V+ +AE+ D  +  LVP W+P   +  +    Y
Sbjct:   19 EVDPTGRYGRYNDVLGKGASKTVYRAFDEYQGMEVAWNQVKLHDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDVSRRNINFITEMFTSGTLRQYRQKHMRVNIWAVKHWCRQILSGLLYLHSHDPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAVHCVGTPEFMAPEVYEEEYNELVDIYSFGMCVLEMVTFEYPYSECTHPVQIYKKVISGTKPEALYKVKDPMVRQFVEKCLATASRRLSARELLKDPFLQVDDLVFCPGDGDYSLMNYLRQPYLEHAYSNVSMMSNGLSESIDEDTPTEDRWDCEDDDIKADGIDLFNGHEDEPLGNVDITIKGRKSEDGSIFLRLRIADNDGHVRNIYFPFDIEADTALSVATEMVAELDITDHEVTRIAEMIDGEVSALVPDWRPGPGIEESQDTTY 454          

Query:   40 EKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQ----KLFTLPEPTSNSS-----------------------VLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSEL 1194
            EKDPTGRY+RYDE+LG+GAFKTVYKAFDEV+G+EVAW QV+I+ V    +++ERLYSEVHLLKSLKH+NI++F+NSWVDDKN TINMITEL TSG+LRQYR KHK VDMKAIKNWARQILRGL YLH+ +P IIHRDLKCDN+ VNG NGE+KIGDLGLAIVMQQP A S+IGTPEFMAPELY+EEYNELVDIYSFGMCMLEMV CEYPYSECKN AQIYK VTSG+KPASL KV++ Q+K+FIEKCLVPAS+RLSA +LLKDP LAT+N  E    LSQL     K   LP+  S+                          LEL  F++NNEFRLRA KN DNTVSLTLRIAD CG  RNI F FYL+SDT +SIA EMVEQLDLS EDV+V+AEL D+ IVKLVP W  SS +
Sbjct:   16 EKDPTGRYVRYDEILGKGAFKTVYKAFDEVDGIEVAWNQVDIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYNSWVDDKNKTINMITELLTSGNLRQYRKKHKTVDMKAIKNWARQILRGLQYLHTRSPRIIHRDLKCDNILVNGNNGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVTSGIKPASLVKVNDLQVKEFIEKCLVPASVRLSAIDLLKDPFLATENSKEVVSSLSQLPNVICKQVHLPQSESHHMDIDCKMLSLGSCPKSINESPQFLTLELRRFTENNEFRLRAEKNDDNTVSLTLRIADPCGRARNIHFTFYLNSDTAVSIAEEMVEQLDLSSEDVAVIAELIDSLIVKLVPCWNTSSSV 431          

Query:    1 MDSCSGLEDAGVV--EKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLP---------------------------EPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPS 1185
            MD  S  ED G V  EKDPTGRY+R DE LG+GAFKTVYKAFDEV+G+EVAW QVNI+ V    +++ERLYSEVHLLKSLKH+NI++F++SWVDDKN TIN+ITELFTSGS+RQYR KHK VDMKAIKNWARQILRGL YLH+H+PPIIHRDLKCDN+FVNG  GE+KIGDLGLAIVMQQP A S+IGTPEFMAPELY+EEYNELVDIYSFGMCMLEMV CEYPYSECKN AQIYK V+SG+KPASL KV + Q+K FIEKCLVPAS RL A ELLKDP LAT+N  E      QL  L +                               +   S LEL  F++NNEFRLR  KN DNTVSLTLRIAD CG  RNI F FYLDSDT + IA EMVEQLDL  EDV+V+AEL DN I KLVP W  S
Sbjct:    1 MDFGSLSEDGGGVFAEKDPTGRYIRNDEFLGKGAFKTVYKAFDEVDGIEVAWNQVNIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYSSWVDDKNKTINIITELFTSGSMRQYRKKHKTVDMKAIKNWARQILRGLHYLHTHSPPIIHRDLKCDNIFVNGNTGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVSSGIKPASLGKVSDHQVKVFIEKCLVPASTRLPAIELLKDPFLATENSKELVSSSLQLPNLISRQVHLLQSESHLMDIDCKKLSVGSCTKSINESPQFSTLELSRFTENNEFRLRGAKNNDNTVSLTLRIADPCGRARNIHFTFYLDSDTAVLIAEEMVEQLDLLTEDVAVIAELIDNLIAKLVPSWNTS 428          

Query:   13 SGLEDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDN------------------LNESSCDLSQLQ----KLFTLP--------EPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSELSLADKDRYDALK 1230
            S ++D GVVEKDPT RY RYDE+LG+GAFKTVYKAFDEV+G+EVAW Q++I+ V    + +E+LYSEVHLLKSLKH+NI++ ++SWVD+K+  INMITELFTSGSLRQYR KHK VDMKAIKNWARQILRGL +LHSHNPP+IHRDLKCDN+FVNG NG++KIGDLGLAIVMQQPTA S+IGTPEFMAPELY+EEYNELVD+YSFGMC+LEM+ CEYPYSECKN AQIYK VTSG+KPASL++V++P++KQFIEKCLVPASMRL A+ELLKDP LAT N                  LN  +C+   ++       T P        E +  SS  ++   ++NNEFRLR  KN D T+SLTLRIAD  G  RNI F FY+DSDT ISIA EMVE L+L  EDV+V+AEL  N I KLVP WKP  E S    + Y  L+
Sbjct:    3 SEIDDVGVVEKDPTLRYARYDEMLGKGAFKTVYKAFDEVDGIEVAWNQISIEDVMQSPQNLEKLYSEVHLLKSLKHENIIKMYSSWVDEKSSNINMITELFTSGSLRQYRKKHKNVDMKAIKNWARQILRGLCFLHSHNPPVIHRDLKCDNIFVNGNNGQVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDVYSFGMCILEMITCEYPYSECKNPAQIYKKVTSGIKPASLARVNDPEVKQFIEKCLVPASMRLPASELLKDPFLATGNTKEIYHDNLLLPNPPSKSLNPPTCEPHPMEIDSNVKHTSPASTVERDKETSQVSSNHDILRKTENNEFRLRGEKNADRTISLTLRIADANGGARNIHFPFYIDSDTTISIAEEMVEHLELKDEDVAVIAELIHNMIFKLVPDWKPLCENSSGTDNLYRPLE 442          

Query:    1 MDSCS-GLEDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNES-----------------------SCDLSQLQKLFTLPEPTSNS------SVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSELS 1197
            MD CS   +D+   EKDPTGRY+RYDEVLG+GAFKTVYKAFDE+ G+EVAW QV+++ V    +++ERLYSEVHLLKSLKH+NI++F+NSWVDD N TINMITELFTSGSLR+YR KHK VD+KAIKNWARQILRGL YLHSHNPPIIHRDLKCDN+FVNG NGE+KIGDLGLA VMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMC+LEMV CEYPYSECKN AQIYK VTSG+KPASL KV++P +K+FIEKC+VPASMRL A ELLKDP LAT+N  E                          D+    K  ++   T +       S  E    +  NEFRLR  KN DNT+SLTLRI D CG V+NI F FYLDSDT +SIA EMVEQLDLS+EDV+++AEL D  I+KLVP    S   S
Sbjct:    1 MDFCSRDDDDSEFEEKDPTGRYVRYDEVLGKGAFKTVYKAFDEINGIEVAWNQVSVEDVLQSPDQLERLYSEVHLLKSLKHENIMKFYNSWVDDNNKTINMITELFTSGSLRKYRKKHKNVDIKAIKNWARQILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILEMVTCEYPYSECKNPAQIYKKVTSGIKPASLCKVNDPLVKRFIEKCIVPASMRLPALELLKDPFLATENPKELVFASLHLPDLMLKQVSRGQSESYPMDIDSNHKKLSVGSCTKSMDESLHFSTSEFQRLTVKNEFRLRGEKNDDNTISLTLRIVDRCGGVKNIHFTFYLDSDTTLSIAEEMVEQLDLSNEDVAIIAELIDALILKLVPHLSQSGSTS 433          

Query:   22 EDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNE--------SSCDLSQ-----LQKLFTLPEP-------------------------TSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSELSL 1200
            +D+   EKDPTGRY+RY+E LG+GAFKTVYKAFDEV+G+EVAW QV I+ +    +++ERLYSEVHLLKSLKH NI++F+NSWVDD N TIN+ITELFTSGSLRQYR KHK VD+KAIKNWA+QILRGL YLHSHNPPIIHRDLKCDN+FVNG NGE+KIGDLGLAIVMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMC+LE+V CEYPY+ECKN AQIYK V+SG+KPASL KV +PQ+KQFIEKCLVPAS+RLSA ELLKD   AT+N  E        SS D S      +  L  LP+P                         T +   L+   F+KNN F+LR  K  DN++S+TL IAD CG  +NI F FYLDSDT +SIA EMVEQLDL +EDV+V+AEL D  I +LVP WKP+ E  L
Sbjct:    9 DDSDFEEKDPTGRYVRYNEFLGKGAFKTVYKAFDEVDGIEVAWGQVEIEDLLQSPQQLERLYSEVHLLKSLKHDNIIKFYNSWVDDTNKTINLITELFTSGSLRQYRKKHKNVDLKAIKNWAKQILRGLHYLHSHNPPIIHRDLKCDNIFVNGNNGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCEYPYNECKNPAQIYKKVSSGIKPASLGKVSDPQVKQFIEKCLVPASLRLSAQELLKDAFFATENSKEPLSVSTHKSSVDDSLQSSNFMPNLMNLPKPELQPMDMDPNYKKLSVSTHMKSISGTPHFRALQFERFNKNNLFKLRGEKIDDNSISMTLHIADPCGRAKNIHFAFYLDSDTALSIAGEMVEQLDLYNEDVAVIAELIDVMISELVPTWKPAFESML 443          

Query:   34 VVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQL----QKLFTLP-------------------------EPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSE 1191
            VVEKD T RY RYDE+LG+GAFKTVYKAFDEV+G+EVAW  ++++ V    +++E+LYSE+HLLKSLKH N+++ +NSWVDD   TINMITELFTSGSLRQYRNKHK VDMKAIKNWARQILRGL +LH H+PPI+HRDLKCDN+FVNG +G +KIGDLGLAIVMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMC+LEMV CEYPYSEC N AQIYK VTSG+KPA+L+KV++P++KQFIEKCLVPASMRLSA+ELLKDP LAT+N  E + D+ +L     KL   P                         E TS  S  +L   ++NN+F LR  KN ++T+SLTLRIA+ CG  RNI F FY++SDT ISIA EMVE L+L++EDVSV+AEL ++ I KLVP  KP SE
Sbjct:    6 VVEKDLTSRYARYDELLGKGAFKTVYKAFDEVDGIEVAWNMISVEDVVQTPQQLEKLYSEIHLLKSLKHDNVIKLYNSWVDDTTGTINMITELFTSGSLRQYRNKHKNVDMKAIKNWARQILRGLCFLHCHSPPIVHRDLKCDNIFVNGNSGLVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILEMVTCEYPYSECNNPAQIYKKVTSGIKPAALAKVNDPEVKQFIEKCLVPASMRLSASELLKDPFLATENTKEINHDILELPNPHTKLVNPPTCEPHPMEIDSKSRRTSPGSSMGRIEETSQVSFFDLVRMTENNKFMLRGEKNAESTISLTLRIANACGGARNIHFPFYINSDTAISIAEEMVEHLELTNEDVSVIAELINDMIAKLVPNLKPLSE 424          

Query:   34 VVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQ----KLFTLP-------------------------EPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSE 1191
            VVEKDPT RY RYDE+LG+GAFKTVYKAFDEV+G+EVAW ++ ++ V    +++ +LYSEVHLLKSLKH N+++ +NSWVDD   TINMITELFTSGSLRQYR KHK VDMKAIKNWARQILRGL +LHS +PPI+HRDLKCDN+FVNG +G +KIGDLGLAIVMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMC+LEMV CEYPYSECKN AQIYK VTSG+KPA+L+KV++P++KQFIEKCLVPASMRLSA+ELLKDP LAT+N  E + D  QL     KL  LP                         E TS  S  +L   + NN+  LR  KN ++T+SLTLRI D CG  RNI F FY+DSDT ISIA EMVE L+L++EDVSV+AEL ++ I KLVP  KP  E
Sbjct:    6 VVEKDPTSRYARYDELLGKGAFKTVYKAFDEVDGIEVAWNRIGVEDVVQTPQQLGKLYSEVHLLKSLKHDNVIKLYNSWVDDTAGTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARQILRGLCFLHSQSPPIVHRDLKCDNIFVNGNSGLVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILEMVTCEYPYSECKNPAQIYKKVTSGIKPAALAKVNDPEVKQFIEKCLVPASMRLSASELLKDPFLATENTKEINHDTLQLPNPHIKLVNLPKCEPHPMEIDSYSRRTSPGSSMGRIEETSQVSFFDLVRMTDNNKLMLRGEKNAESTISLTLRIPDACGGARNIHFPFYMDSDTAISIAEEMVEHLELTNEDVSVIAELINDMIAKLVPNSKPLCE 424          

Query:   28 AGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATD-NLNESSCDLSQLQKLF----TLPEP-------------------------TSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWK 1179
            A +VEKDPTGRY+RYD+VLG+GAFKTVY+AFDEV+G+EVAW QV I  V    E+ E+LYSEV+LL+SL+H+NI++F NSWVDDKN TINMITELFTSG+LRQYR KH+ +D+KAIKNWARQILRGL YLH H+PPIIHRDLKCDN+FVNG +GE+KIGDLGLAIVMQ PTA S+IGTPEFMAPELY+EEYNELVDIYSFGMC+LE+V C YPYSEC+N AQIYK VTSG+KPASL  V N QIK+FIEKCL+PAS RLSA ELLK P L  +  + E  CD   +   F    +LP+                          +  S VLE     KNNEF L+  KN DN+ SLTLRI+D  G VRNI F FYLDSDT IS+A EMVEQL+L+  DV+ +AEL D+ IVKL+PGWK
Sbjct:    8 ADLVEKDPTGRYVRYDDVLGKGAFKTVYRAFDEVDGIEVAWNQVRIDDVLRSPEDFEKLYSEVYLLRSLRHENIIKFSNSWVDDKNKTINMITELFTSGNLRQYRRKHRNIDIKAIKNWARQILRGLVYLHGHSPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQNPTAKSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCNYPYSECRNAAQIYKKVTSGIKPASLKTVGNTQIKEFIEKCLLPASERLSAKELLKHPFLQLEIPILEQICDPLPVPDQFPISLSLPKSGPLFMDMDIDEKQLSESTCTGSNNGSPKSPVLEYQRAHKNNEFGLKGMKNDDNSASLTLRISDLGGRVRNIHFIFYLDSDTAISVASEMVEQLELADHDVAFIAELIDSLIVKLLPGWK 425          

Query:    1 MDSCSGLEDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNES-----------------------SCDLSQLQKLFTLPEPTSNSS-----VLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKP 1182
            M      ++A  VEKDPTGRY+R+ E+LG+GAFKTVYKAFDEV+G+E+AW QV I  V    E++E+LYSEVHLLKSLKH+NI++F+NSWVDDK  T+NMITELFTSGSLRQYR KHK VDMKAIKNWARQ+LRGL YLHSHNPPIIHRDLKCDN+FVNG +GE+KIGDLGLAIVMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMCMLEMV  EYPY+ECKN AQIYK VTSG+KPASL KV + QIK+FI KCL PAS RL A ELLKDP   ++N  E                        S D+       +    T N+      VLE     K++EFRLRA K  DN++SLTLR  D+ G V+NI F F LD+DTV S+  EMVEQL+L+  +V+ +A+  D  I++L+PGWKP
Sbjct:    9 MQGAEDEDEAAYVEKDPTGRYVRFKEILGKGAFKTVYKAFDEVDGIEIAWNQVKIDDVLRSPEDLEKLYSEVHLLKSLKHENIIKFYNSWVDDKKKTVNMITELFTSGSLRQYRKKHKNVDMKAIKNWARQVLRGLVYLHSHNPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYNECKNPAQIYKKVTSGIKPASLCKVTDLQIKEFIVKCLAPASERLPAKELLKDPFFQSENPKEPIRVPLQLPSRSPKSIILSKSGPFSMDIDPDHPQLSSSTSTENNGSPDFPVLEFQRMYKSSEFRLRAKKINDNSISLTLRTVDSYGPVKNIHFPFSLDTDTVHSVVGEMVEQLELAEHEVAFIADFIDYVIMRLLPGWKP 434          

Query:   37 VEKDPTGRYLRYDEVLGRGAFKTVY------KAFDEVEGVEVAWCQVNIKG----VEEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNES----------------------SCDLSQLQKLFTLP------EPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSE 1191
            VEKDPTGRY+R +E+LGRGAFKTVY      + FDEV+G+EVAW QV I G    V+++ +LYSEV+LLKSLKH+NI++F++SW+DDK  T+NMITELFTSG+LRQYR KHK V+MKAIK WARQIL GL YLHSH PPIIHRDLKCDN+FVNG  GE+KIGDLGLAIVMQQPTA S+IGTPEFMAPELY+E Y ELVDIYSFGMC+LEMV  EYPYSEC+N AQI+K VTSG+KPASL+KV +PQ+K FIEKCLVPAS RLSA ELLKDP L  +N  +                       S D+    K F++       +   +  + E+    KNN+FRL+  KN  N+VSLTLRIADTCG VRNI F FY D+DT +S+A EMVE L+L+  DV  +AEL D  I+KL+P WKPS +
Sbjct:   59 VEKDPTGRYIRNNEILGRGAFKTVYDSDAYYRGFDEVDGIEVAWNQVKIDGLMHSVDDLAKLYSEVNLLKSLKHENIIKFYDSWIDDKKKTVNMITELFTSGNLRQYRKKHKYVEMKAIKGWARQILHGLVYLHSHKPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAIVMQQPTAQSVIGTPEFMAPELYEEAYTELVDIYSFGMCILEMVTLEYPYSECQNPAQIFKKVTSGIKPASLNKVSDPQLKDFIEKCLVPASERLSADELLKDPFLQVENPKDPILYPLQPPSRTLRAYSFKSGSLSMDMDSDYKPFSMSIYSESNQENPHCPIFEVQRTYKNNKFRLKGTKNDVNSVSLTLRIADTCGRVRNIHFLFYPDTDTAVSVATEMVEHLELADHDVDFIAELIDYLIMKLLPWWKPSPD 481          

Query:   13 SGLEDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGVEEV----ERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLS-----------QLQKLFTLPEPTSNSSV-----------LELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLV 1167
            S +E+A   EKDP+GRY+RYD+VLGRGAFKTVYKAFDEV+G+EVAW  V+I+ V ++    ERLYSEVHLLK+LKH+NI++   SWVD+KN TINMITELFTSGSLR YR KH+KVD KAIKNWARQIL+GL+YLHS NPP+IHRDLKCDN+FVNG  GE+KIGDLGLA V+QQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMCMLEMV CEYPY+EC+N AQIYK VTS +KP SL KVD+PQ++QFIEKCL+PAS R +A EL KDP LA D   +S+   S           QL+ L    +   N SV           +EL   ++N EFRLR  ++ D T S+ LRIAD  G  R + F FYL+SDT  +IA EMVE+L L+ ++V V+A++ D+ I++L+
Sbjct:   12 SSMEEADFAEKDPSGRYIRYDDVLGRGAFKTVYKAFDEVDGIEVAWNLVSIEDVMQMPGQLERLYSEVHLLKALKHENIIKLFYSWVDEKNKTINMITELFTSGSLRVYRKKHRKVDPKAIKNWARQILKGLNYLHSQNPPVIHRDLKCDNIFVNGNTGEVKIGDLGLATVLQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYNECRNQAQIYKKVTSNIKPQSLGKVDDPQVRQFIEKCLLPASSRPTALELSKDPFLARDGGKDSALLASSSTSSKYVRPPQLEHLPMDVDHNENKSVSSNEDYPWSQTIELQRIAENKEFRLRGERSDDVTASMVLRIADPSGKCRIVHFAFYLESDTATAIAEEMVEELHLTSQEVVVIADMIDDFIMQLL 422          

Query:   19 LEDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLPEPT-----------SNSSV-----------------LELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGW---KPSSELSLADKDRYDALKRELDAIGKQYFSKLREEE 1284
            +E+A  V+KDPTGRY+RY++VLGRGAFKTVYKAFDEVEG+EVAW  ++I+ V     +++RLYSEVHLL SLKH NI++   SWVDD N +INMITELFTSGSL  YR KH+KVD KAI NWARQIL+GL YLHS  PP+IHRDLKCDN+FVNG  G++KIGDLGLA VMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMCMLEMV CEYPY EC+N AQIYK VTSG+KP SLSKVD+PQ+KQFIEKCL+PA  R +A ELLKD +LA D   +S+   S          P             N+SV                 +E+   +++ EF+L   +  D   S+ LRIA + G  R + FDF L +DT  ++  EMVE+LDLS  +V+V+AE+ D  I+KL         +S     D++  +++K E+ A    Y+ ++   E
Sbjct:    1 MEEADFVQKDPTGRYIRYNDVLGRGAFKTVYKAFDEVEGIEVAWNLMSIEDVLQMPGQLDRLYSEVHLLNSLKHDNIIKLFYSWVDDHNKSINMITELFTSGSLTLYRKKHRKVDPKAIMNWARQILKGLHYLHSQTPPVIHRDLKCDNIFVNGNTGKVKIGDLGLAAVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYRECRNQAQIYKKVTSGIKPQSLSKVDDPQVKQFIEKCLLPAPSRPTALELLKDQLLAVDGAKDSTLTASSNTTFKPAMPPQCEYRPMDVEYKKNTSVSICSSAKSSQECALLQTMEVQRVAESTEFKLSGERRDDVAASMALRIAGSSGQARKVDFDFNLKTDTARAVTGEMVEELDLSSHEVTVIAEMIDELIMKLKANRSLPNANSVYQSKDEEAGESMKSEISA---DYYHRVSSNE 454          

Query:    4 DSCSGLE---DAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGVEE----VERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESS------------------CDLSQ--------------LQKLFTLPEPT----SNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWK 1179
            D  S L+   D  V+E DPT RY+RY EV+G+GAFKTVYKAFDEV+G+EVAW QV I  V +    +ERLYSEV LLKSLKH NI++F+NSW+DDKN T+N+ITELFTSGSLR YR KH+KV+MKA+KNWARQIL GL YLH   PPIIHRDLKCDN+F+NG +GE+KIGDLGLA VM+Q  A S+IGTPEFMAPELYDE YNEL DIYSFGMCMLEMV  +YPY ECKN AQIYK V+SG+KPASLS+V +P++KQFIEKCL+PAS RLSA ELL DP L  + L  ++                  C +S+              L +   LP  T    S S  +E+    + N F L+  +N + +VSL LRI D  G VRNI F FY + DT   ++ EMVEQL+L+ ++V+ +AEL D  +V ++P WK
Sbjct:    5 DDASALQEPPDPEVLEVDPTFRYIRYKEVIGKGAFKTVYKAFDEVDGIEVAWNQVRIDDVLQSPNCLERLYSEVRLLKSLKHNNIIRFYNSWIDDKNKTVNIITELFTSGSLRHYRKKHRKVNMKAVKNWARQILMGLRYLHGQEPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFDYPYCECKNSAQIYKKVSSGIKPASLSRVKDPEVKQFIEKCLLPASERLSAKELLLDPFLQLNGLTMNNPLPLPDIVMPKEGAFGDRCLMSEGPPTTRPSKTLSIDLDEDSNLPIVTFSDNSGSRCIEVRRAKRGNFFVLKGEENDEQSVSLILRIVDENGRVRNIHFLFYQEGDTASKVSSEMVEQLELTDQNVTFIAELIDILLVNMIPTWK 439          

Query:    4 DSCSGLE---DAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGVEE----VERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESS------------------CDLSQ--------------LQKLFTLPEPT----SNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWK 1179
            D  S L+   D  V+E DPT RY+RY EV+G+GAFKTVYKAFDEV+G+EVAW QV I  V +    +ERLYSEV LLKSLKH NI++F+NSW+DDKN T+N+ITELFTSGSLR YR KH+KV+MKA+KNWARQIL GL YLH   PPIIHRDLKCDN+F+NG +GE+KIGDLGLA VM+Q  A S+IGTPEFMAPELYDE YNEL DIYSFGMCMLEMV  +YPY ECKN AQIYK V+SG+KPASLS+V +P++KQFIEKCL+PAS RLSA ELL DP L  + L  ++                  C +S+              L +   LP  T    S S  +E+    + N F L+  +N + +VSL LRI D  G VRNI F FY + DT   ++ EMVEQL+L+ ++V+ +AEL D  +V ++P WK
Sbjct:    5 DDASALQEPPDPEVLEVDPTFRYIRYKEVIGKGAFKTVYKAFDEVDGIEVAWNQVRIDDVLQSPNCLERLYSEVRLLKSLKHNNIIRFYNSWIDDKNKTVNIITELFTSGSLRHYRKKHRKVNMKAVKNWARQILMGLRYLHGQEPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFDYPYCECKNSAQIYKKVSSGIKPASLSRVKDPEVKQFIEKCLLPASERLSAKELLLDPFLQLNGLTMNNPLPLPDIVMPKEGAFGDRCLMSEGPPTTRPSKTLSIDLDEDSNLPIVTFSDNSGSRCIEVRRAKRGNFFVLKGEENDEQSVSLILRIVDENGRVRNIHFLFYQEGDTASKVSSEMVEQLELTDQNVTFIAELIDILLVNMIPTWK 439          

Query:   25 DAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGVEE----VERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNL----------------------------------NESSCDLSQLQKL-FTLPEPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWK 1179
            D  V+E DPT RY+RY EV+G+GA KTV+K FDEV+G+EVAW QV I  + +    +ERLYSEV LLKSLKH+NI++F+NSW+DDKN T+N+ITELFTSGSLRQYR KH+KV+MKA+K WARQIL GL YLHS +PPIIHRD+KCDN+F+NG +GE+KIGDLGLA VM+Q  A S+IGTPEFMAPELYDE YNEL DIYSFGMCMLEMV  EYPY EC+N AQIYK V+SG+KPASLSKV +P++ +FIEKCL+PAS RLSA ELL D  L  + L                                     S +L +   L   +    S ++ +E+    + N F L+  +N +N+VSL LRI D  G VRNI F F+ + DT  +++ EMVEQL+L+ ++V  +AEL D  +V L+P WK
Sbjct:   15 DPEVLEIDPTCRYIRYKEVIGKGASKTVFKGFDEVDGIEVAWNQVRIDDLLQSPDCLERLYSEVRLLKSLKHKNIIRFYNSWIDDKNKTVNIITELFTSGSLRQYRKKHRKVNMKAVKCWARQILTGLKYLHSQDPPIIHRDIKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFEYPYCECRNSAQIYKKVSSGIKPASLSKVKDPEVMKFIEKCLLPASERLSAEELLLDSFLNVNGLVMNNPLPLPDIVMPKEGSFGERCLMSEGPPNARNRTMSMNLDEDNNLPIVISSNNSGTNCIEVRRAKRGNFFVLKGEENDENSVSLILRIVDENGRVRNIHFLFFQEGDTASNVSSEMVEQLELTDKNVKFIAELIDVLLVNLIPNWK 438          

Query:   37 VEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIK----GVEEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQP-TAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLPEPTSN-SSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLS-HEDVSVVAELXDNSIVKLVPGWKPS 1185
            VE DPTGRY RY EVLG+GAFK VY+AFD++EG+EVAW QV +       E+++RLYSEVHLLK+LKH++I++F+ SW+D ++MTIN+ITE+FTSG+LRQYR KHK VD++A+K W+RQIL GL YLHSH+PP+IHRDLKCDN+F+NG  GE+KIGDLGLA ++ +  +AHS+IGTPEFMAPELY+E+YN LVDIY+FGMC+LE+V  EYPYSEC N AQIY+ VTSG+KPA+L  V +PQ++ FIEKC+   S RLSA ELL DP L         C     + + +  E   N + +++    S+     +   +   NT+ L LRI D+ G +RNI F F +++DT  S+A EMVE+LDL+  +D+S +A++ D  I   +P W PS
Sbjct:   13 VEIDPTGRYGRYKEVLGKGAFKEVYRAFDQLEGIEVAWNQVKLDDKFCSSEDLDRLYSEVHLLKTLKHKSIIKFYTSWIDHQHMTINLITEVFTSGNLRQYRKKHKCVDLRALKKWSRQILEGLVYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILHRARSAHSVIGTPEFMAPELYEEDYNVLVDIYAFGMCLLELVTFEYPYSECTNAAQIYRKVTSGIKPAALLNVTDPQVRAFIEKCIAKVSQRLSAKELLDDPFL--------KCYKENTENVSSHKENGYNGNGIVDKLSDSEVGLLTVEGQRKDLNTIFLKLRITDSKGQIRNIHFPFNIETDTSFSVAIEMVEELDLTDDQDISTIAKMIDTEIHSHIPDWTPS 394          

Query:  109 YKAFDEVEGVEVAWCQVNIKGVEE----VERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNL----------------------------------NESSCDLSQLQKL-FTLPEPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWK 1179
            +K FDEV+G+EVAW QV I  + +    +ERLYSEV LLKSLKH+NI++F+NSW+DDKN T+N+ITELFTSGSLRQYR KH+KV+MKA+K WARQIL GL YLHS +PPIIHRD+KCDN+F+NG +GE+KIGDLGLA VM+Q  A S+IGTPEFMAPELYDE YNEL DIYSFGMCMLEMV  EYPY EC+N AQIYK V+SG+KPASLSKV +P++ +FIEKCL+PAS RLSA ELL D  L  + L                                     S +L +   L   +    S ++ +E+    + N F L+  +N +N+VSL LRI D  G VRNI F F+ + DT  +++ EMVEQL+L+ ++V  +AEL D  +V L+P WK
Sbjct:   25 FKGFDEVDGIEVAWNQVRIDDLLQSPDCLERLYSEVRLLKSLKHKNIIRFYNSWIDDKNKTVNIITELFTSGSLRQYRKKHRKVNMKAVKCWARQILTGLKYLHSQDPPIIHRDIKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFEYPYCECRNSAQIYKKVSSGIKPASLSKVKDPEVMKFIEKCLLPASERLSAEELLLDSFLNVNGLVMNNPLPLPDIVMPKEGSFGERCLMSEGPPNARNRTMSMNLDEDNNLPIVISSNNSGTNCIEVRRAKRGNFFVLKGEENDENSVSLILRIVDENGRVRNIHFLFFQEGDTASNVSSEMVEQLELTDKNVKFIAELIDVLLVNLIPNWK 420          

Query:   13 SGLEDAGV-VEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLN------------ESSCDLSQLQKLFTLP---EPTSNSSVLELXXFSKNNE----FRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSELS 1197
            S +ED  V VE DP+GRY RYDE+LG+GA KTVY+AFDE EG+EVAW QV ++      EE+E+ + E+HLLK+L HQNI++F+ SWVD  N++IN +TELFTSG+LRQYR +H++V+++A+K W +QIL+GL YLHS +PPIIHRDLKCDN+F+NG  GE+KIGDLGLA ++++  A   +GTPEFMAPE+YDEEYNELVD+Y+FGMC+LEMV  +YPYSEC + AQIYK VTSG KP +   V +P++++F+EKCL   + RL+A ELL+DP L  DN++                 +     L   P   +   +S + E+  F+ ++E      ++  +N D+ + L LRI+D  G +RNI F F    DT  S+A EMV +LD++++DV+ +AE+ D  I  LVP WK  +E S
Sbjct:    6 SFVEDCSVFVEIDPSGRYGRYDEILGKGASKTVYRAFDEYEGIEVAWNQVKLRNFTRNPEELEKFFREIHLLKTLNHQNIMKFYTSWVDTNNLSINFVTELFTSGTLRQYRLRHRRVNIRAVKQWCKQILKGLLYLHSRSPPIIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAVRCVGTPEFMAPEVYDEEYNELVDVYAFGMCVLEMVTFDYPYSECTHPAQIYKKVTSGKKPEAFYLVKDPEVREFVEKCLANVTCRLTALELLQDPFLQDDNMDGFVMRPIDYYNGYDETGVFLRHPLIDDPLYHDQFESSQICEIDLFANDDEDHVDISIKGKRNGDDGIFLRLRISDAEGRIRNIYFPFETAIDTAWSVAVEMVSELDITNQDVAKIAEMIDAEIAALVPDWKNDTESS 424          

Query:   37 VEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNI----KGVEEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDN--LNESSCDL------------------------SQLQKLFTLPEPTSNSSVLE---LXXFSKNNEFRLRAGKNPDNT-------------------------VSLT--------------LRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSE 1191
            VE DPTGRY RY+EVLG+GA KTVY+AFDE EG+EVAW QV +    +  E++ERLY E+HLLK+LKH+NI++F+ SWVD  N  IN +TELFTSG+LRQYR +HK+V+++A+K+W RQILRGL YLHSH+PP+IHRDLKCDN+FVNG  GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+E YNELVDIYSFGMC+LEMV  +YPYSEC + AQIYK V SG KP +L KV +P++K FIEKCL   S+R+SA ELL DP L  D+   +  S D+                        S L + ++     SNSS L       ++ ++E++     NP  T                         V +T              LRIAD  G VRNI F F +++DT +S+A EMV +LD+    V+ +A + D  I  LVP W+P  E
Sbjct:   15 VEVDPTGRYGRYNEVLGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTELFTSGTLRQYRLRHKRVNIRAMKHWCRQILRGLHYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFDYPYSECTHPAQIYKKVMSGKKPDALYKVKDPEVKCFIEKCLATVSLRVSARELLDDPFLRIDDGEFDLRSVDMEDSVGPLYRQPHHLPDYYNYPSNSSSLNRQYSNGNYPSNSSSLNRQYSNGYNSHHEYQNGWAYNPAETEETHGIELFESRNNDDQEEEKKSGNVDITIKGKRRDDGGLFLRLRIADKEGRVRNIYFPFDIETDTALSVATEMVAELDMDDHGVTKIANMIDGEISSLVPSWRPGPE 471          

Query:    1 MDSCSGLED--AGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNI----KGVEEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLN----ESSCDL-----SQLQKLFTLP-------------------EPTSNSSVLELXXFSKNNEFRLR-----------AGKNPDNTVSLTLRI--ADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGW 1176
            M++ S LE   +  VE DPTGRY RY+EVLG+G+ KTVY+ FDE +G+EVAW QV +    +  +E+ERLY E+HLLK+LKH++I++F+ SWVD  N  IN +TE+FTSG+LRQYR KHK+V+++A+KNW RQILRGL+YLH+H+PP+IHRDLKCDN+F+NG  GE+KIGDLGLA  +Q   A   +GTPEFMAPE+Y EEYN+LVDIYSFGMC+LEMV  +YPYSEC + AQIYK V SG KP  L KV +P+++ FIEKCL   S+RLSA ELL D  L  D  +    ES   L     + L+  + +P                   + T  S  ++L  F  +++                GK  DN   L LR+   +  G VRNI F F +++DT IS+A EMVE+L++   DV+ +A + D  I  LVP W
Sbjct:    2 MNNLSHLESDYSEYVEVDPTGRYGRYNEVLGKGSSKTVYRGFDEYQGIEVAWNQVKLYDFLQSPQELERLYCEIHLLKTLKHKSIMKFYASWVDTDNRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKNWCRQILRGLNYLHTHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAACLQHSHAAHCVGTPEFMAPEVYKEEYNQLVDIYSFGMCVLEMVTFDYPYSECSHPAQIYKRVISGKKPDGLDKVKDPEVRGFIEKCLATVSLRLSACELLDDHFLCIDESDMRRVESEKGLIDEAGTPLRHSYHIPHYSNGYYSLYNQNQWDYNGDETVESHEIDLLEFQNDDDEEEEDKRFGSVDISIKGKRRDNGDGLFLRLKTVNKEGCVRNIYFPFDIETDTAISVAREMVEELEMDDRDVTKIANMIDGEIASLVPNW 440          

Query:   40 EKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQ----KLFTLPEPTSNSS-----------------------VLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSEL 1194
            EKDPTGRY+RYDE+LG+GAFKTVYKAFDEV+G+EVAW QV+I+ V    +++ERLYSEVHLLKSLKH+NI++F+NSWVDDKN TINMITEL TSG+LRQYR KHK VDMKAIKNWARQILRGL YLH+ +P IIHRDLKCDN+ VNG NGE+KIGDLGLAIVMQQP A S+IGTPEFMAPELY+EEYNELVDIYSFGMCMLEMV CEYPYSECKN AQIYK VTSG+KPASL KV++ Q+K+FIEKCLVPAS+RLSA +LLKDP LAT+N  E    LSQL     K   LP+  S+                          LEL  F++NNEFRLRA KN DNTVSLTLRIAD CG  RNI F FYL+SDT +SIA EMVEQLDLS EDV+V+AEL D+ IVKLVP W  SS +
Sbjct:   16 EKDPTGRYVRYDEILGKGAFKTVYKAFDEVDGIEVAWNQVDIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYNSWVDDKNKTINMITELLTSGNLRQYRKKHKTVDMKAIKNWARQILRGLQYLHTRSPRIIHRDLKCDNILVNGNNGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVTSGIKPASLGKVNDLQVKEFIEKCLVPASVRLSAIDLLKDPFLATENSKEVVSSLSQLPNVICKQVHLPQSESHHMDIDCKMLSLGSCPKSINESPRFLTLELRRFTENNEFRLRAEKNDDNTVSLTLRIADPCGRARNIHFTFYLNSDTAVSIAEEMVEQLDLSSEDVAVIAELIDSLIVKLVPCWNTSSSV 431          

Query:    1 MDSCSGLEDAGVV--EKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLP---------------------------EPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPS 1185
            MD  S  ED G V  EKDPTGRY+R DE LG+GAFKTVYKAFDEV+G+EVAW QVNI+ V    +++ERLYSEVHLLKSLKH+NI++F++SWVDDKN TIN+ITELFTSGS+RQYR KHK VDMKAIKNWARQILRGL YLH+H+PPIIHRDLKCDN+FVNG  GE+KIGDLGLAIVMQQP A S+IGTPEFMAPELY+EEYNELVDIYSFGMCMLEMV CEYPYSECKN AQIYK V+SG+KPASL KV + Q+K FIEKCLVPAS RL A ELLKDP LAT+N  E      QL  L +                               +   S LEL  F++NNEFRLR  KN DNTVSLTLRIAD CG  RNI F FYLDSDT + IA EMVEQLDL  EDV+V+AEL DN I KLVP W  S
Sbjct:    1 MDFGSLSEDGGGVFAEKDPTGRYIRNDEFLGKGAFKTVYKAFDEVDGIEVAWNQVNIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYSSWVDDKNKTINIITELFTSGSMRQYRKKHKTVDMKAIKNWARQILRGLHYLHTHSPPIIHRDLKCDNIFVNGNTGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVSSGIKPASLGKVSDHQVKVFIEKCLVPASTRLPAIELLKDPFLATENSKELVSSSLQLPNLISRQVHLLQSESHLMDIDCKKLSVGSCTKSINESPQFSTLELSRFTENNEFRLRGAKNNDNTVSLTLRIADPCGRARNIHFTFYLDSDTAVLIAEEMVEQLDLLTEDVAVIAELIDNLIAKLVPSWNTS 428          

Query:   28 AGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATD-NLNESSCDLSQLQKLF----TLPEP-------------------------TSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSS 1188
            A +VEKDPTGRY+RYD+VLG+GAFKTVY+AFDEV+G+EVAW QV I  V    E+ E+LYSEV+LL+SL+H+NI++F NSWVDDKN TINMITELFTSG+LRQYR KH+ +D+KAIKNWARQILRGL YLH H+PPIIHRDLKCDN+FVNG +GE+KIGDLGLAIVMQ PTA S+IGTPEFMAPELY+EEYNELVDIYSFGMC+LE+V C YPYSEC+N AQIYK VTSG+KPASL  V N QIK+FIEKCL+PAS RLSA ELLK P L  +  + E  CD   +   F    +LP+                          +  S VLE     KNNEF L+  KN DN+ SLTLRI+D  G VRNI F FYLDSDT IS+A EMVEQL+L+  DV+ +AEL D+ IVKL+PGWKPSS
Sbjct:    8 ADLVEKDPTGRYVRYDDVLGKGAFKTVYRAFDEVDGIEVAWNQVRIDDVLRSPEDFEKLYSEVYLLRSLRHENIIKFSNSWVDDKNKTINMITELFTSGNLRQYRRKHRNIDIKAIKNWARQILRGLVYLHGHSPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQNPTAKSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCNYPYSECRNAAQIYKKVTSGIKPASLKTVGNTQIKEFIEKCLLPASERLSAKELLKHPFLQLEIPILEQICDPLPVPDQFPISLSLPKSGPLFMDMDIDEKQLSESTCTGSNNGSPKSPVLEYQRAHKNNEFGLKGMKNDDNSASLTLRISDLGGRVRNIHFIFYLDSDTAISVASEMVEQLELADHDVAFIAELIDSLIVKLLPGWKPSS 428          

Query:   25 DAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPIL----------------------------------ATDNLNESSCDLSQLQKLFTLP------EPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGL-VRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKP 1182
            D  V+E DPT RY+RY EVLG+GAFKTVYKAFDEV G+EVAW QV I  V    +++ERLYSE+HLLK+LK+ NIV+F+NSW+DDK  T+N+ITELFTSGSLRQY  KH+K++MKA+K WARQIL GL+YLH+H+PPIIHRDLKCDN+F+NG  GE+KIGDLGLA VM+Q  A S+IGTPEFMAPELYDE YNEL DIYSFGMCMLEMV  EYPYSEC+N AQIYK V+SG+KPASLSKV +P +KQFIEKCL+PAS RL A ELL DP L                                  AT      S DLS   ++ T+       +  ++S  LE+    + N F LR   N +N+VSL LR+AD  G  VRNI F FYLD DT +S++ EMVEQL+L  E+V  +AEL D  ++KL+P WKP
Sbjct:   15 DPDVLEIDPTCRYIRYKEVLGKGAFKTVYKAFDEVNGIEVAWNQVRIDEVLQSPDDLERLYSEMHLLKTLKNSNIVRFYNSWIDDKKKTVNIITELFTSGSLRQYCKKHRKIEMKAVKGWARQILNGLNYLHNHDPPIIHRDLKCDNIFINGNQGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFEYPYSECRNSAQIYKKVSSGIKPASLSKVKDPDLKQFIEKCLLPASERLPAKELLMDPFLDVNGFARNSSMSRSDILMSKMTAIGDRCLMSEGPATARNKPPSMDLSHDPEMPTITSFNNSVDEDTHSLCLEVRRAKRGNVFLLRGEGNDENSVSLILRMADQNGARVRNIHFLFYLDGDTALSVSSEMVEQLELEVENVKFIAELIDLLLLKLIPNWKP 445          

Query:   19 LEDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV--EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQL------QKLFTLPEPTSNS-----------------------SVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADT-CGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPS 1185
            L++ G VEKDPTGRY+RYDE+LG G  KTVY+AFDEV+GVEVAW Q N++ V  +++ER  SE  LLKSLK++NI++F++ W+DD+  T+NMITE+F SGSL QY  KHK VD KAIKNWARQILRGL YLH+H PPII  +LKCD++FVNG NGE+KIGDLGLAIV QQPT  S +GTP +MAPEL ++EYNELVD+YSFGMCMLEMV CEYPY E KN  Q+YK V SGVKPASL+KV++PQ+KQFIEKCLVPAS+RL A ELLKDP LAT+N  ++     +L      +++  LP   S S                       S LE+  F++ NEFRLR  K   NT+SL L I +T C L R + F F+LDSDT +S+A EMVEQL LS ED +  AEL D  ++KLVP WK S
Sbjct:    3 LDNDGFVEKDPTGRYVRYDEILGGGTVKTVYRAFDEVDGVEVAWKQANVEDVSQKQLERWTSEARLLKSLKNKNIIKFYDFWIDDEKKTLNMITEIFVSGSLSQYCKKHKDVDTKAIKNWARQILRGLHYLHNHEPPIILGNLKCDSIFVNGNNGEVKIGDLGLAIVTQQPTGSSDLGTPAYMAPELCEDEYNELVDVYSFGMCMLEMVTCEYPYCEIKNPGQVYKKVISGVKPASLNKVNDPQVKQFIEKCLVPASLRLPAIELLKDPFLATENSKDTVSGSMKLPNNLMPKQVINLPHSESRSMDIDDKKLLVGSCKESIDEKLQFSTLEICKFTEKNEFRLRGEKIDSNTISLNLNITETSCSLERKVEFPFHLDSDTAVSVAEEMVEQLGLSPEDAAYNAELIDILVMKLVPSWKTS 423          

Query:   37 VEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV--EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAP-ELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNE---SSCDL--SQLQKLFTLPEPTSNSSVLELXXFS--------KNNEFRLRAGKNPDNTVSLTLRIADT-CGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPS--SELSLADKDRYDALKRELDAIGKQYFSKLREEEMQSAKKSWIAENK 1323
            +EKDPTGR++R DE+LG G  KT Y+AFDEV+GVEVAW QVN++ V  +++ERL +E  LLKSLK +NI++ ++ W+DD+  T+NMITE+F SGSL QY  KHK V+ KA+KNWARQILRGL YLH+H PPIIH DL+CDN+FVNG NGE+KIGDLGLAIVMQ+PT    +GTP +MAP +L +EEYNELVD+YSFGMCMLEMV  EYP  ECKN  QIYK V SGVKPASL KV++PQ+KQFIEKCLVPAS+RLSA ELLKDP LAT+N  +   SS  L  + + K   L   +   S+ E   FS        + NEFRLR  K  +NT+SLTL I +T C   R + F FYLDSDT +S+A EMVEQL+LS ED +  A+L D  ++KLVP  K S  S  S  D+   D L+   +    Q F+     E      S    NK
Sbjct:    7 LEKDPTGRFVRSDEILGGGVVKTAYRAFDEVDGVEVAWKQVNVEHVSPKQLERLTTEARLLKSLKDKNIIKIYDFWIDDEKKTLNMITEIFVSGSLSQYCKKHKGVNAKAVKNWARQILRGLHYLHTHEPPIIHGDLRCDNIFVNGNNGEVKIGDLGLAIVMQRPTGLCDLGTPAYMAPDQLCEEEYNELVDVYSFGMCMLEMVTREYPCCECKNPGQIYKKVISGVKPASLDKVNDPQVKQFIEKCLVPASLRLSAIELLKDPFLATENSKDTVSSSMKLPNNLMPKQKKLLVGSCKESINEQLQFSTPEICKVNEKNEFRLRGEKIDNNTISLTLNITETSCCQSREVEFSFYLDSDTAVSVAEEMVEQLELSPEDAACSAKLIDALVMKLVPSLKTSCGSIASAPDQRHPDCLQSVREQEALQSFNSEISAEQDMTISSCARTNK 454          

Query:   25 DAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNI----KGVEEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQP-TAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLPEPTSNSSVLELXXFSKN---NEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGW 1176
            DA  VE DPTGRY RY EVLGRGAFK VY+AFDE EG+EVAW QV +    +   ++ERLYSEVHLL +LKH+NI++F+NSW+D KN  IN ITE+FTSG+LRQYR KHK V ++A+K W+RQIL GL YLHSH+PP+IHRDLKCDN+FVNG  GE+KIGDLGLA ++QQ  +AHS+IGTPEFMAPELY+EEYNELVDIY+FGMC+LE+V  EYPY EC N AQIYK VTSG+KPASL+KV +P +K FIEKC    S RL A ELL DP L +D  NE S   S   K  +    +    V E+   S      +F ++  +   NT+ L LRIAD+ G +RNI F F ++ DT I++A EMVE+LDL+ +DVS +A + D+ I   +PGW
Sbjct:   15 DAEFVEIDPTGRYGRYKEVLGRGAFKKVYRAFDEFEGIEVAWNQVKVADLLRNSVDLERLYSEVHLLNTLKHKNIIKFYNSWIDTKNENINFITEIFTSGTLRQYRQKHKHVGLRALKKWSRQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILQQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCLLELVTVEYPYVECTNAAQIYKKVTSGIKPASLAKVKDPAVKAFIEKCTAKVSDRLPAKELLMDPFLQSDEENE-SVGHSFRPKAHSSGGSSDQIDVNEIAKDSSAEPIRDFTVQGQRKDINTIFLKLRIADSTGHIRNIHFPFDVEVDTAIAVASEMVEELDLTDQDVSTIAAMIDSEIRSHIPGW 405          

Query:   25 DAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNI----KGVEEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQP-TAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNES-SCDLSQLQKLFTLPEPTSNSSV---LELXXFSK--------NNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPS--SELSLADKDRYDALKRELDAIGKQYFSKLRE-----EEMQSAKKSW 1308
            DA  VE DP+GRY RY EVLGRGAFK VY+AFDE+EG+EVAW QV +    +   ++ERL+SEVHLLK+LKH+NI++F+NSWVD KN  IN ITE+FTSG+LR+YR KHK VD++A+K W++QIL GL YLHSH+PP+IHRDLKCDN+FVNG  GE+KIGDLGLA ++QQ  +AHS+IGTPEFMAPELY+EEYNELVDIY+FGMC+LE+V  EYPY EC N AQIYK VTSG+KPASL+KV +P +K FIEKC+   S RL A ELL DP L +D  N S  C L         P+  S+  +   L++   +K        + +F ++  +   NT+ L LRIAD+ G  RNI F F +  DT I++A EMVE+LD++ +DVS +A + D+ I   +P W  +  S  +LA +D     + + D+      S L       E++ S  K W
Sbjct:   15 DAEFVEIDPSGRYGRYKEVLGRGAFKKVYRAFDELEGIEVAWNQVKVADLLRNSVDLERLFSEVHLLKTLKHKNIIKFYNSWVDTKNENINFITEIFTSGTLRKYRQKHKHVDLRALKKWSKQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILQQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCLLELVTVEYPYVECSNAAQIYKKVTSGIKPASLAKVKDPAVKAFIEKCIAKVSDRLPAKELLMDPFLRSDEENVSGGCSLR--------PKAHSSGGISDQLDVNESAKDKDSAAESSRDFSVQGQRKDINTIFLKLRIADSTGHFRNIHFPFDVKVDTAIAVASEMVEELDVTDQDVSTIAAMIDSEIRSHIPDWDSNNVSPENLAAEDSEPPSETKDDSSPLSNESSLSPGSLVLEKLSSGHKYW 458          

Query:   37 VEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQV----NIKGVEEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQL---------------QKLFTLPEPTSNSSV--------------------LELXXFS------------KNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSELSLADKDRYDALKRELDAIGK--QYFS 1266
            VE DPTGRY RY+E+LG+GA KTVYKAFDE EG+EVAW QV    +++  E++ERLY E+HLLK+L H+NI++F+ SWVD  N  IN +TE+FTSG+LRQYR KH++V+++A+K+W RQIL GL YLHSH+PP+IHRDLKCDN+FVNG  GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+EEYNELVDIYSFGMC+LEMV  EYPYSEC + AQIYK VTSG KP +L KV +P++++F+EKCL   S RLSA ELL DP L  D   +S CDL  +               Q L  +    SNSS+                    LEL                +N    ++  +  D+++ L LRIAD  G +RNI F F +++DT IS+A EM+++LD++ +DV  VA++ D+ I  LVP WK    +  + +  Y +  +   + G    YFS
Sbjct:   15 VEVDPTGRYGRYNEILGKGASKTVYKAFDEYEGIEVAWNQVKLYDSLQTSEDLERLYCEIHLLKTLNHENIMKFYTSWVDTSNRNINFVTEMFTSGTLRQYRLKHRRVNIRAVKHWCRQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEIKIGDLGLAAILKKSHAARCVGTPEFMAPEVYEEEYNELVDIYSFGMCVLEMVTFEYPYSECNHAAQIYKKVTSGKKPDALYKVKDPELQKFVEKCLATVSTRLSARELLNDPFLQID---DSGCDLKPIDYYQGDLNGVGPLVRQPLHGIHR--SNSSLTDGYTNYMGYDLENEIEYHQLELETSPIDLFTCQEDENLENVAIAIKGRRIEDDSIFLRLRIADKEGRIRNIYFSFDIETDTAISVATEMIDELDITEQDVLKVAKMIDDEISTLVPEWKRGRGIEESPQSTYASFCQNCASHGHLLDYFS 472          

Query:   37 VEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNI----KGVEEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATD------NLNESSCDLSQLQKLFTLP----EPTSNS--------------------------SVLELXXF----SKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKP 1182
            VE DPTGRY RY+E+LGRGA K VY+AFDE EG+EVAW QV +    +  E++ERLY E+HLLK+LKH+NI++F+ SWVD  N  IN +TE+FTSG+LRQYR KHK+V+++A+K+W RQILRGL YLHSH+PP+IHRDLKCDN+FVNG  GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+E YNELVDIYSFGMC+LEMV  EYPYSEC +  QIYK V SG KP +L KV +P+++ F+EKCL   S+RLSA ELL DP L  D       L +   ++  L  L   P       +NS                          S +EL  +      N +  ++  +  D  + L LRIAD  G +RNI F F +++DT +S+A EMV +LD++ +DV+ +A++ D  I  LVP W+P
Sbjct:   16 VEVDPTGRYGRYNEILGRGASKIVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPVQIYKKVISGKKPDALYKVKDPEVRHFVEKCLATVSLRLSARELLNDPFLQIDGCESDLRLLDHRIEVDGLGPLMRPPYLEHHDNNNSYSSGYLNGYDYEAQNEWEYHQVEVELSGIELFEYHDEHPANVDISIKGKRGDDGGIFLRLRIADKEGRIRNIYFPFDIENDTALSVATEMVAELDITDQDVTKIADMIDGEIASLVPEWRP 441          

Query:  100 KTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQL----QKLFTLPEP-------------------------TSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSELS 1197
            K  YKAFDEVEG+EVAWCQV+I+ V    E++ERLYSEVHLLKSLKHQNIV+F NSWVDDKN TINMITELFTSGSLRQYR KHK VDMKAIKNWAR ILRGL YLHSHNPPIIHRDLKCDN+FVNG NGE+KIGDLGLAIVMQQPTAHS+IGTPEFMAPELYDEEYNELVDIYSFGMCMLEMV CEYPYSECKN AQIY+ VTSG+KPASLSKV+NPQ+KQFIEKCLVPAS+RL+A ELLKDP LATDNL E SCDLSQL     KL  LP+P                         TSNSSVLE   F++NNEFRLRA +N D TVSLTLRIADTCG VRNI F+FYLDSDT +SIA EMVEQLDLSHEDVSV+AEL D  I+KLVPGWKPSSE S
Sbjct:   80 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSQLPNPVPKLVNLPQPEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPSSESS 478          

Query: 1186 SELSLADKDRYDALKRELDAIGKQYFS------KLREEEMQSAKKSWIAENKIAV 1332
            SELSL DKDRYD LK EL AI  QY        ++REEE+Q+AKK WI + KIAV
Sbjct:  592 SELSLVDKDRYDELKGELVAIDVQYHQCLLELLRMREEEIQNAKKRWIEKKKIAV 646          

Query:   22 EDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQ----KLFTLPEP---------------------TSNSS--VLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSELS 1197
            E+A  VE+DP+ RY+RY+E+LG+GAFKTVYKAFDEV+G+EVAW QV I  V    E++E+LYSEVHLLKSL H+NI++F+NSWVD+   TINMITELFTSGSLRQYR K+K VD KAI+NWARQILRGL +LHSHNPPIIHRDLKCDN+F+NG +GE+KIGDLGLA VMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMCMLEMV  EYPYSECK+ AQI+K VTSG+KPASL KV++ QIK+FIEKCLV AS RLSA ELLKDP L  DN  E   D  QL     K+  LP+                      ++N S  VLE    +KNN+FRL   KN D++VSLTLRIA  CG VRNI F FYL +DT +S+  EMVEQL L+  DV+ +AE  D  I+KL+PGWKPS + S
Sbjct:   24 EEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKPSPDYS 446          

Query:   25 DAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNI----KGVEEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQP-TAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLPEPTSNS---SVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSELS 1197
            DA  VE DPTGRY RY E+LG+GAFK VY+AFDE+EG+EVAW QV +    +  E++ERLYSEVHLLK+LKH+NI++F+NSWVD K+  IN ITE+FTSG+LRQYR KHK VD++A+K W+RQIL GL YLH+H+PP+IHRDLKCDN+FVNG  GE+KIGDLGLA +++Q  +AHS+IGTPEFMAPELY+EEYNELVDIY+FGMC+LE+V  EYPY EC N AQI+K VTSG+KPASL+KV +P +K FIEKC+   S RLSA ELL  P L +D   E     S L+      E +S+       ++    + N+     G+  D+T+ L LRIAD+ G  RNI F F + +DT I++A EMV++LDL+ +DV+ +AE+ D  I   +P W  SSE+S
Sbjct:   15 DAEFVEVDPTGRYGRYKEILGKGAFKKVYRAFDELEGIEVAWNQVKVADLLRNSEDLERLYSEVHLLKTLKHKNIIKFYNSWVDAKHENINFITEIFTSGTLRQYRRKHKHVDLRALKKWSRQILEGLWYLHNHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCLLELVTFEYPYVECTNAAQIFKKVTSGIKPASLAKVTDPGVKAFIEKCITKVSDRLSAKELLMHPFLQSDQDRE----CSSLRPETHYSEGSSDQIDIGTKDMDPSPETNKDFTVQGQRKDDTIFLKLRIADSTGHFRNIHFPFDIGADTAIAVASEMVQELDLTDQDVTTIAEIIDAEIQSHIPDW-TSSEIS 408          

Query:   37 VEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNI----KGVEEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLN------ESSCDLSQLQKLFTLPEPT---SNSS-------------------------VLELXXFSKNN-------EFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWK 1179
            VE DPTGRY RY+EVLG+GA KTVY+AFDE EG+EVAW QV +    +  E++ERLY E+HLLK+LKH NI++F++SWVD  N  IN +TE+F SG+LRQYR KHK+V+++A+K+W RQIL+GL YLHSH+PP+IHRDLKCDN+F+NG  GE+KIGDLGLA V+++  A   +GTPEFMAPE+Y+EEYNELVDIYSFGMC+LEMV  EYPYSEC + AQIYK V SG KP +L KV +P++++F+EKCLV  S RLSA ELLKDP L  D+        E   D+S++  L   P      SNSS                         + E+  F+          +  ++  +  D+ + L LRIAD  G +RNI F F  ++DT +S+A EMV +LD++ +DV+ +AE+ D  I  LVPGWK
Sbjct:   15 VEVDPTGRYGRYNEVLGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLRNPEDLERLYREIHLLKTLKHNNIMKFYSSWVDTANRHINFVTEMFISGTLRQYRLKHKRVNIRAVKHWCRQILKGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAVLRKSHADRCVGTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPEALYKVKDPEVRRFVEKCLVAVSRRLSARELLKDPFLRVDDYGYDLRSIEYPRDMSEIGPLLRQPYSELHHSNSSLSNGYGHCLGYETENDLDYHSVDYRLSEIDLFACQEDEHLGDLDLTIKGRRREDDGIFLRLRIADKEGRIRNIYFPFDTETDTALSVAREMVAELDITDQDVTKIAEMIDGEIATLVPGWK 440          

Query:   25 DAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNI----KGVEEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATD---------NLNESSCDLSQL--QKLFTLPEPTSN-------------------------SSVLEL-----XXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKP 1182
            D+  VE DPTGRY RY+E+LG+GA KTVY+AFDE EG+EVAW QV +    +  E++ERLY E+HLLK+LKH+NI++F+ SWVD  N  IN +TE+FTSG+L+QYR KHK+V+++A+K+W RQILRGL YLHSH+PP+IHRDLKCDN+F+NG  GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+E YNELVDIYSFGMC+LEMV  EYPYSEC + AQIYK V SG KP +L KV +P+++QF+EKCL  AS+RLSA ELL D  L  D         +      D+  L  Q LF L    S+                         SS +EL        S++ +  ++  +  D  + L LRIAD  G +RNI F F +++DT  S+A EMV +LD++ +DV+ +A++ D  I  LVP W+P
Sbjct:   11 DSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRSNSSFSNGYSNGFGYDSQNEWGYHPVDAESSGIELFEHHDDEHSEDVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQP 441          

Query:   70 YDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQ-QPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLPEPTSNSSVLEL------XXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGL-VRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWK 1179
            + E+LG+GA KTVYKAFDEV G+EVAW QV +K V    +E++RLYSEVHLLK+L H +I+Q++ SW+D    T N ITE+FTSG+LR+YR K+++V++ A+KNWARQILRGL YLH  +PP+IHRDLKCDN+FVNG  G++KIGDLGLA V++    AHS+IGTPEFMAPELY+EEYNELVDIY+FGMC+LEM+  EYPYSEC N AQIYK VTSG  P +  K+++ + ++F+ KCL  AS RL A ELL DP LA+D+    S      Q L     P  +S+V+E+          +  E  L  G   D+T+ L ++I+D  G   RNI F F + +DT I++A EMV++L++S  + S +AE+ +  I  L+PG K
Sbjct:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLM----PNDDSAVVEVEEEEEEEEEEEEEELPLDLG---DDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHK 375          

Query:   37 VEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGVEE----VERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLA-IVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDP 819
            VE DP+GRY RY+E+LG GA K VY+AFD+ +G+EVAW QV ++        +ERLY+EV LL+SL  +NI+  +N W D +N T+N +TE+ T+G+LR YR KHK V + A+K W++QIL+GL+YLH+H P +IHRDL C N+F+NG  G++KIGDLGLA IV +  +AHS++GTPEFMAPELY+E+Y E+VDIYSFGMC+LEMV  E PYSEC N+ +IYK VTSGV+P SL+KV++P++K F+EKCL     R SA ELL DP
Sbjct:   16 VEIDPSGRYGRYNELLGCGAVKKVYRAFDQEDGIEVAWNQVKLRNFTNDPAMIERLYAEVGLLRSLADKNIITLYNVWRDAENNTLNFMTEVCTNGNLRDYRKKHKHVSLIALKKWSKQILKGLEYLHTHEPCVIHRDLNCSNVFINGNIGQVKIGDLGLAAIVGKNHSAHSVLGTPEFMAPELYEEDYTEMVDIYSFGMCVLEMVTLEIPYSECDNVVKIYKKVTSGVRPQSLNKVEDPEVKAFVEKCLAQPRARPSATELLNDP 281          

Query:   37 VEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGVEE----VERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLA-IVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLN 843
            VE DPTGR+ RYD++LG GA K VY+AFD+ EG EVAW QV ++   E    + RLYSEV LL +LK++ I+  ++ W D+ + T+N ITE+ TSG+LRQYR KH+ V ++A+K W+RQ+L GL+YLH+H P IIHRDL C N+F+NG   ++KIGDLG A IV +   AHSIIGTPE+MAPELY+E+Y E+VDIYSFGMC+LEMV  E PYSEC ++A+IYK VT+G+KP  L+KV +P++K FIEK +     R SA++LLKDP L+    N
Sbjct:   17 VEVDPTGRFGRYDDLLGHGAVKKVYRAFDQEEGTEVAWNQVRLRTFSEDPTLINRLYSEVKLLSTLKNKYIIVCYSVWRDEAHNTLNFITEVCTSGNLRQYRKKHRHVSIRALKKWSRQVLEGLEYLHTHEPCIIHRDLNCSNIFINGNTAQVKIGDLGFAAIVGKNHEAHSIIGTPEYMAPELYEEDYTEMVDIYSFGMCLLEMVTMEIPYSECDSVAKIYKKVTAGIKPEGLNKVTDPEVKAFIEKSIAQPRARPSASDLLKDPFLSEPKSN 290          

Query:  298 LFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQ-QPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLPEPTSNSSVLELXXFSKN---NEFRLRAGKNP-DNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKPSSELSLADKDRYDALKR 1233
            +FTSG+LR+YR K+K VD++AIKNWARQILRGL YLH ++PP+IHRDLKCDN+FVNG  G++KIGDLGLA +++   +AHS+IGTPEFMAPELYDE YNELVD+YSFGMC+LEM+  EYPYSEC N AQIYK VTSG  P +  ++ + + ++FI KCLV AS RL A ELL DP L      +    L +L +    P+P  N   +E    S +    +  +    NP D+T+ L ++IAD  G  RNI F F + +DT   +A EMV++L+++  +   +A + +  I  LVP WK  +  ++  +D  D  +R
Sbjct:    1 MFTSGTLREYRKKYKHVDIRAIKNWARQILRGLVYLHGNHPPVIHRDLKCDNIFVNGHLGQVKIGDLGLATILRGSQSAHSVIGTPEFMAPELYDENYNELVDVYSFGMCVLEMLTSEYPYSECVNPAQIYKKVTSGKLPGAFYRIQDLEAQRFIGKCLVNASKRLPAKELLLDPFLECG--KDEPLPLGKLGR----PKPFLNDKEMEKLQLSDDQTRTDMTITGKLNPEDDTIFLKVQIADKDGSFRNIYFPFDILNDTPFDVATEMVKELEITDWEPFEIANMIEWEISALVPNWKTEAYHTINYQDDDDGPQR 311          

Query:  403 LHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQ-QPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQKLFTLPEPTSNSSVLELXXFSKNNEFRLRAGKNP--------DNTVSLTLRIADTCGL-VRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWK 1179
            LH  +PP+IHRDLKCDN+FVNG  G++KIGDLGLA V++    AH +IGTPEFMAPELY+EEYNELVDIY+FGMC+LEM+  EYPYSEC N AQIYK VTSG  P +  K+++ + ++F+ KCL  AS  L A ELL DP LA+D+    S      Q L     P  +S+V+E     +  E      +          D+T+ L +RI+D  G   RNI F F + +DT I++A EMV++L++S  + S +AE+ +  I  L+PG K
Sbjct:    1 LHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHCVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKMLPAHELLLDPFLASDDRELLSTPRIPFQNLM----PNDDSAVVEEEEEEEEEEEEEEEEEEEEELPLDLGDDTIFLQVRISDQDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHK 265