ppa001969m, ppa001969m (mRNA) Prunus persica

Query:    1 MNGLVEPDYSD-SEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHY 1590
            MNG++ P+  D SEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKT+KH NIMKFYTSWVDTANRNINFVTEMFTSGTL+QYR KHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEE YNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKV+SGKKPDALYKVKDPEVR+FVEKCLA+ SLRLSARELL D FL+ID+C+ DLRP++  R+ DDM                                         E +GIELF          VDISIKGKRRED GIFLRLRIADKE  IRNIYFPFDIE DTA SVATEMVAELDITDQDVT+IADMIDGEIA LVP+W+PGPGI ETP +A    C                      AKNLQ+ Q C  GCA+MHGRFEE+TYQ D ++HH+ EG      QS+ LHY
Sbjct:    1 MNGVINPEADDYSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTMKHNNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRQKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVREFVEKCLASVSLRLSARELLQDPFLRIDDCESDLRPIECRREPDDM----------------------------------------MEPTGIELFEYHEDEHPANVDISIKGKRREDDGIFLRLRIADKEDHIRNIYFPFDIEMDTALSVATEMVAELDITDQDVTKIADMIDGEIASLVPEWKPGPGIEETPCFATLNLC----------------------AKNLQIFQ-CSNGCAAMHGRFEEITYQVDGADHHIPEG------QSEELHY 462          

Query: 1807 DLSDTHENEIQE-FRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQ----------RNLSPNFHANLNKSCEV-MVSPNAED---EVTGKSFCT-GSLLPQSLRRTVSLPVDAVDV 2202
            +L   +ENEIQ+  RWLKAKHQME+R LRD Q+   SK S   +++ +  N  L S +S+T QG NN +  KS AYD+             SP+   +  ++CE    S +AED    VT KSF T GSLLP  + RT+SLPVDAVD+
Sbjct:  459 ELHYDYENEIQQVLRWLKAKHQMEMRGLRDLQLGFASKPSSLDNRQLKPDNEGLFSTLSNTSQGHNNGLFLKSSAYDKHFTSNCATQVNKCSPDLVTHGARNCEANKGSRSAEDMVHVVTAKSFYTAGSLLPCPIHRTMSLPVDAVDI 606          

Query:   13 VEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQ-GFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSD 1578
            +EPDYS  EFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKL DFLQSPE+LERLYCEIHLLKTLKH NIMKFYTSWVD ANRNINFVTEMFTSGTL+QYRLKH+RVNIRAVKHWCRQILRGLLYLH+H PPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEE YNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKV+SGKKPDALYKVKDPEVRQFVEKCLAT +LRLSARELL D FLQ D+   DLRP++Y R + ++GPL R P                          +G H ++ E + I+LF          VDISI+G++R+D GIFLRLRI+DKEGR+RNIYFPFD+ETDTA SVA EMV+ELDITDQDVT+IADMID EIA LVP W+ G GI E+  Y +   FCH+                          LQC +QGCA++HGRFEE+TY+         EG  N  +QS+
Sbjct:    7 LEPDYS--EFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLNDFLQSPEELERLYCEIHLLKTLKHNNIMKFYTSWVDPANRNINFVTEMFTSGTLRQYRLKHRRVNIRAVKHWCRQILRGLLYLHNHKPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVRQFVEKCLATVTLRLSARELLKDPFLQSDDYGSDLRPIEYQRDLGEVGPLPRLP-------------------------HYGIHHIEFERNEIDLFTYQEDEHLENVDISIEGRKRDDHGIFLRLRISDKEGRVRNIYFPFDMETDTALSVAMEMVSELDITDQDVTKIADMIDDEIASLVPGWKMGLGIEESQNYGHDASFCHH-------------------------FLQCSRQGCAAVHGRFEEITYR--------VEGVINIDNQSE 469          

Query:   16 EPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQP 1323
            +PD  D+EFVE+DPTGRYGRY E+LGKGA K VYRAFDE EGIEVAWNQVK+ D L++ E+ ERLY E+HLLKTLKHKNI+KFY SWVDT N NINF+TE+FTSGTL+QYR KHK V++RA+K W RQIL GLLYLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILR++ +AH V GTPEFMAPE+YEE YNELVDIY+FGMC+LE+VTFEYPY EC + AQIYKKV SG KP +L KVKDP VR F++KC+A  S RLSA+E                              LLR P  +                     ++   H     SS + L            D  ++G+RR+   IFL+LRIAD +G IRNI+FPFDI  DTA SVA EMV ELD+TDQDV+ IA MID EI  ++ DW P
Sbjct:   10 DPDDPDTEFVEIDPTGRYGRYKEVLGKGAFKKVYRAFDELEGIEVAWNQVKVADLLRNSEEFERLYSEVHLLKTLKHKNIIKFYISWVDTRNENINFITEIFTSGTLRQYRKKHKHVDLRALKKWSRQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCLLELVTFEYPYVECANAAQIYKKVTSGIKPASLAKVKDPRVRAFIDKCIANVSDRLSAKE------------------------------LLRDPFLQSDEENGSVGRSLQPHPHHSGSHD---HFNTGTSSKVSL-------PESSRDFKVQGQRRDVNTIFLKLRIADSKGHIRNIHFPFDIGADTAISVAGEMVEELDLTDQDVSTIAAMIDSEIRSIISDWPP 406          

Query:    7 GLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAE---SSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQP 1323
            G+   +  D + +E+DPT RY R+ +ILGKGA KTVY+AFD+ +GIEVAWNQV++ + LQSP++LERLY E+HLLK+LKHKNI+KFY SW+D  N+ +N +TE+FTSG+L+QYR KHK+V+++AVK W RQIL GL YLH+H+PP+IHRDLKCDNIFINGNQGEVKIGDLGLA ++++++A   +GTPEFMAPE+Y+E YNEL DIYSFGMC+LEMVT EYPYSEC + AQIYKKV +G KP AL K+KD EV+ F+EKCL  AS RLSA++LLND F Q+D         ++  Q+ D+ P++                        D+  + G + +  E   + G   F              +KG+  ++  I L LRIAD+ GR+RNI+F F +++DTA SV++EMV +L++ DQ+VT IA++ID  + +L+P W+P
Sbjct:   12 GIGHSEPPDPDVLEIDPTSRYIRFKDILGKGAFKTVYKAFDQVDGIEVAWNQVRIDEVLQSPDELERLYSEVHLLKSLKHKNIIKFYNSWIDDGNKTVNIITELFTSGSLRQYRKKHKKVDMKAVKGWARQILMGLNYLHNHNPPIIHRDLKCDNIFINGNQGEVKIGDLGLATVMQQANARTVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTLEYPYSECRNSAQIYKKVSNGIKPAALSKIKDLEVKMFIEKCLVPASQRLSAKKLLNDPFFQVDGLTK-----NHPLQLPDILPIITS---------------------MDNSVDGGPYSLCMEVQRAKGGNFFL-------------LKGEGNDENSISLILRIADQNGRLRNIHFMFYLDSDTALSVSSEMVEQLELADQNVTFIAELIDLLLIMLIPTWKP 414          

Query:   31 DSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGG-IFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQ 1320
            +S + E DPTGRYGR +E+LGKGA KTVY+A DE  G+EVAWNQVKL + L+SP++L+RLY E+HLL  L H +I++FYTSW+D   +  NF+TE FTSGTL++YR K+KRV+IRA+K W RQILRGL+YLH HDPPVIHRDLKCDNIF+NG+ GEVKIGDLGLAAILR S +AH V GTPEFMAPE+YEE YNELVD+YSFGMC+LEM+T EYPYSEC++PAQIYKKV SGK P A Y+++D E ++F+ KCL TAS RL A+ELL D FL  DE     +P     ++    P L                                       + I +            +++I G    D   IFL+++ ADK+G  RNIYFPFDI TDT   VA EMV EL+ITD +   IADMIDGEI+ LVP W+
Sbjct:   16 ESGYAETDPTGRYGRLDEVLGKGAMKTVYKAIDEVLGMEVAWNQVKLNEVLRSPDELQRLYSEVHLLSALNHDSIIQFYTSWIDVERKTFNFITEFFTSGTLREYRKKYKRVDIRAIKCWARQILRGLVYLHGHDPPVIHRDLKCDNIFVNGHLGEVKIGDLGLAAILRGSQSAHSVIGTPEFMAPELYEENYNELVDVYSFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPGAFYRIQDLEAQRFIGKCLVTASKRLPAKELLLDPFLASDEAKRLPKP-----KLGSQKPFL---------------------------------------NDIRIEKLRLSDDRVRTNMTITGTLNPDDDTIFLKVQTADKDGSARNIYFPFDIVTDTPIDVAMEMVKELEITDWEPFEIADMIDGEISALVPQWK 403          

Query:   19 PDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQP 1323
            P   DS+F E DPTGRY RYNE LGKGA KTVY+AFDE +GIEVAW QV++ D LQSP+ LERLY E+HLLK+LKH NI+KFY SWVD  N+ IN +TE+FTSG+L+QYR KHK V+++A+K+W +QILRGL YLHSH+PP+IHRDLKCDNIF+NGN GEVKIGDLGLA ++++  A   +GTPEFMAPE+YEE YNELVDIYSFGMCILE+VT EYPY+EC +PAQIYKKV SG KP +L KV DP+V+QF+EKCL  ASLRLSA+ELL D F   +     L    +      M  +   P F                                 +   E F              ++G++ +D  I + L IAD  GR +NI+F F +++DTA S+A EMV +LD+ ++DV  IA++ID  I+ LVP W+P
Sbjct:  145 PLTDDSDFEEKDPTGRYVRYNEFLGKGAFKTVYKAFDEVDGIEVAWGQVEIEDLLQSPQQLERLYSEVHLLKSLKHDNIIKFYNSWVDDTNKTINLITELFTSGSLRQYRKKHKNVDLKAIKNWAKQILRGLHYLHSHNPPIIHRDLKCDNIFVNGNNGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCEYPYNECKNPAQIYKKVSSGIKPASLGKVSDPQVKQFIEKCLVPASLRLSAQELLKDAFFATENSKEPLSVSTHKSMSTHMKSISGTPHF--------------------------------RALQFERFNKNNL-------FKLRGEKIDDNSISMTLHIADPCGRAKNIHFAFYLDSDTALSIAGEMVEQLDLYNEDVAVIAELIDVMISELVPTWKP 540          

Query:   40 FVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGK-RREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQ 1320
            +VE DP+GRYGR+ EILGKGA KTVY+AFDE+ G+EVAWNQVKL D   SP+DL+RLY E+HLLK L H +IM+F+TSW+D      NF++EMFTSGTL++YR K+KRV+I AVK+W RQIL GL YLH HDPPVIHRDLKCDNIF+NG+ G+VKIGDLGLAAILR S  AH V GTPEFMAPE+YEE Y+ELVD+YSFGMC+LEM+T EYPY EC++PAQIYKKV SGK P+A Y+++D E R+FV +CL   + RL A+ELL D FL           VD+G Q   M P+L+                        SQ       V+   S                D++I G    +D  IFL++ I+DK+G  RNIYFPFDI +DT   VA EMV EL+ITD +   IA MI+ EI  LVP W+
Sbjct:   19 YVETDPSGRYGRFREILGKGAMKTVYKAFDEFLGMEVAWNQVKLNDVFNSPDDLQRLYSEVHLLKNLDHDSIMRFHTSWIDLDGGTFNFISEMFTSGTLREYRQKYKRVDIGAVKNWARQILHGLAYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQHAHSVIGTPEFMAPELYEEEYDELVDVYSFGMCVLEMLTSEYPYCECSNPAQIYKKVTSGKLPEAFYRIEDVEAREFVGRCLEHVAKRLPAKELLMDPFL----------AVDHGEQ---MLPMLK----------------------ISSQKPSPNGTVEKIPS------FQTNPRKRSTDMTITGTINPDDYTIFLKVAISDKDGLSRNIYFPFDIGSDTPIDVAAEMVRELEITDWEPFEIAKMIEEEIFALVPSWK 406          

Query:   22 DYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLR 873
            D  ++ +VE DPTGRY R+ EILGKGA KTVY+AFDE +GIE+AWNQVK+ D L+SPEDLE+LY E+HLLK+LKH+NI+KFY SWVD   + +N +TE+FTSG+L+QYR KHK V+++A+K+W RQ+LRGL+YLHSH+PP+IHRDLKCDNIF+NGN GEVKIGDLGLA ++++  A   +GTPEFMAPE+YEE YNELVDIYSFGMC+LEMVTFEYPY+EC +PAQIYKKV SG KP +L KV D ++++F+ KCLA AS RL A+ELL D F Q +     +R
Sbjct:   14 DEDEAAYVEKDPTGRYVRFKEILGKGAFKTVYKAFDEVDGIEIAWNQVKIDDVLRSPEDLEKLYSEVHLLKSLKHENIIKFYNSWVDDKKKTVNMITELFTSGSLRQYRKKHKNVDMKAIKNWARQVLRGLVYLHSHNPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYNECKNPAQIYKKVTSGIKPASLCKVTDLQIKEFIVKCLAPASERLPAKELLKDPFFQSENPKEPIR 297          

Query: 1087 DISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQP----------GPGIVETPRYANQGFCHNCASNHTSSGS 1407
            +  ++ K+  D  I L LR  D  G ++NI+FPF ++TDT  SV  EMV +L++ + +V  IAD ID  I  L+P W+P           P   E P   N G  H+C  +H    S
Sbjct:  317 EFRLRAKKINDNSISLTLRTVDSYGPVKNIHFPFSLDTDTVHSVVGEMVEQLELAEHEVAFIADFIDYVIMRLLPGWKPPRDDPLGGARSPN-AEPPVLGN-GNNHDCTISHGDGNS 431          

Query:   13 VEPDYSDSE---FVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQF---LQIDECDH 864
            V PD SD +   FVEVDPT RYGRYNE+LG GA K VYRAFD+ EGIEVAWNQVKL  F      ++RL+ E+ LLKTLK KNI+  Y  W +  +  +NF+TE+ TSG L++YR KH+ V+++A+K W +QIL+GL YLH H+P +IHRDL C N+FINGN G+VKIGD GLAA + KSH AH V GTPEFMAPE+YEE Y ELVDIYSFGMC LEMVT E PYSEC + A+IYKKV+SG +P A+ KV+DPEV+ F+EKCLA    R SA ELLND F   +  DE D+
Sbjct:    4 VSPDQSDRDSEPFVEVDPTRRYGRYNELLGCGAVKRVYRAFDQEEGIEVAWNQVKLRAFSDDKPMIDRLFSEVRLLKTLKDKNIIALYNVWRNEDHNTLNFITEVCTSGNLREYRKKHRHVSMKALKKWSKQILKGLDYLHRHEPCIIHRDLNCSNVFINGNVGKVKIGDFGLAATVGKSHVAHSVLGTPEFMAPELYEEDYTELVDIYSFGMCFLEMVTLEIPYSECDNIAKIYKKVISGARPRAMDKVRDPEVKAFIEKCLAKPRARPSASELLNDPFFHGIDDDEIDN 294          

Query:   22 DYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQF 840
            D+    FVEVDPTGRYGRY+++LG GA K VYRAFD+ EGIEVAWNQV+L +F +    ++RL+ E+ LL TLK+++I+  Y+ W D  +  +NF+TE+ TSG L+ YR +H+ V+I+A+K W RQ+L+GL YLH+HDP +IHRDL C NIFINGN G+VKIGDLGLAAI+ K+H AH V GTPE+MAPE+YEE Y E+VDIYSFGMC+LEMVT E PYSEC + A+IYKKV SG  P A+ KV DPEV+ F+EKC+A    R SA ELLND F
Sbjct:  540 DHDTEPFVEVDPTGRYGRYSDLLGHGAVKKVYRAFDQEEGIEVAWNQVQLRNFSEDKSMVDRLHSEVKLLSTLKNESIIVLYSVWKDNEHNTLNFITEVCTSGNLRDYRKRHRHVSIKALKKWSRQVLKGLEYLHTHDPCIIHRDLNCSNIFINGNIGQVKIGDLGLAAIVGKNHLAHSVLGTPEYMAPELYEEDYTEMVDIYSFGMCLLEMVTMEIPYSECDNIAKIYKKVTSGVGPLAMNKVSDPEVKFFIEKCIAQPRARPSASELLNDPF 813          

Query:   13 VEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQ-ADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEI-QEFRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSC 2082
            +EPDYS  EFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTL+QYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVD+YSFGMCILEMVTFEYPYSECTHPAQIYKKV+SG+KPDALYKVKDPEVRQFVEKCLAT SLRLSARELLND FLQ+D+C+ +++ +DYG + D MGPL+RQP +E H                ++QNE+ Y+PV+ E SGIELF          +DISIKGKRR+DGGIFLRLRIADK+GRIRNIYFPFDIETDTA +VATEMVAELDITDQDVT+IA+MID EIA LVP+W+ GPGI ETPR+AN   CHNCAS  TS+GS+M+F+SN+P         CC+ GCASMHGRFEE+T+Q ADESEHH+TE APN  S SDC+ YQ IW QHESRE++ +GSG+SHSD EYEK DQ ++ +DE D+++E+   S + NS   L GS SF  +PS   DL D++EN++ QE RWLKAK+Q+EL +LRDQQ+   S+SS + + + ++ NGV SS + ++ Q   N  L KS A+ ++   PN H ++NKSC
Sbjct:    8 LEPDYS--EFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDVYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGRKPDALYKVKDPEVRQFVEKCLATVSLRLSARELLNDPFLQMDDCESNIKSIDYGEEFDGMGPLIRQPYYEFHDDTYPYSNGYSNGYGYEAQNEFEYYPVEFEQSGIELFEHHDDEHSPNLDISIKGKRRDDGGIFLRLRIADKDGRIRNIYFPFDIETDTALTVATEMVAELDITDQDVTKIAEMIDEEIASLVPEWRRGPGIEETPRFANLTLCHNCASARTSNGSLMDFISNNP---------CCRNGCASMHGRFEEITFQAADESEHHLTEVAPNALSHSDCVDYQRIWAQHESREVTPMGSGRSHSDEEYEKFDQSISTKDENDVKMENGSQSGSRNSIPYLKGSGSFYRLPSVCSDLQDSNENKMQQELRWLKAKYQIELSKLRDQQLDFASRSSTSINTDCKIRNGVSSSTIMNSFQENRNEDLLKSFAH-EKLYRPNLHTDVNKSC 687          

Query: 2117 SLARVSAQGHCFLSLFAGQFLSQLMQLM 2200
            SL R+SA  HC  + F GQ   QLM L+
Sbjct:  718 SLPRISALVHCCHTRFTGQHPFQLMLLI 745          

Query:    1 MNGLVE---PDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEI-QEFRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSCEVM---------VSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            MNGL     PDYS  EFVEVDPTGRYGRYNEILG+GASK VYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTL+QYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHP QIYKKV+SGKKPDALYKVKDPEVR FVEKCLAT SLRLSARELLND FLQID C+ DLR +D+  ++D +GPL+R P  E H                ++QNEW YH V+ E SGIELF          VDISIKGKR +DGGIFLRLRIADKEGRIRNIYFPFDIE DTA SVATEMVAELDITDQDVT+IADMIDGEIA LVP+W+PGPGI ETP +ANQ  CHNCAS  TS+GS M+FLSN+P         CC  GCASMHGRF E+ ++ DESEHH+TEGAPN  +Q D LHY+EIWGQ ESR+L+ IGSG+S  D EYE  DQ +  +D +D ++E+      G S ++ +GS S S + S Y+DL+D++ENEI Q+ RWLKAKHQMELR+LRD+++ L  K S + + E + +N V S+ + ++ Q  +N  L KS A   + +S + H +     +             P A+D V  K+ CTG +LP SL RT SLPVDAVDV
Sbjct:    1 MNGLSHLEPPDYS--EFVEVDPTGRYGRYNEILGRGASKIVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPVQIYKKVISGKKPDALYKVKDPEVRHFVEKCLATVSLRLSARELLNDPFLQIDGCESDLRLLDHRIEVDGLGPLMRPPYLEHHDNNNSYSSGYLNGYDYEAQNEWEYHQVEVELSGIELF-EYHDEHPANVDISIKGKRGDDGGIFLRLRIADKEGRIRNIYFPFDIENDTALSVATEMVAELDITDQDVTKIADMIDGEIASLVPEWRPGPGIEETPCFANQTLCHNCASTCTSNGSFMDFLSNNP---------CCSHGCASMHGRFGEIIFEVDESEHHLTEGAPNILNQPDYLHYKEIWGQQESRQLTPIGSGKSQLDEEYENFDQSIPEKDTKDTKMEN--GIPGGKSFQHFTGSGSLSRLTSLYNDLADSNENEIQQDLRWLKAKHQMELRKLRDERLGLAVKPSTSRNGEEKTSNVVSSTSMLNSFQEGSNGDLLKSLA---KQISHSLHTHAGALSDTQRPWNHKVMNQPPRAKDMVNAKNLCTGPMLPHSLHRTTSLPVDAVDV 730          

Query:    1 MNGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELF-XXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEIQ-EFRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSCEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            MNG+   +  +SEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEY+GIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKH+NIMKFYTSWVDTANRNINFVTEMFTSGTL+QYRLKHKRVNIRAVKHWCRQIL GLLYLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKV+SGKKPDALY+VKDPEVRQFVEKCL T SLRLSARELLND FLQID+ ++DL+ V+ G ++D+ G L+RQP F+LHR                 + +WG HP + E SGIELF           VDISIKGKR++DGGIFLRLRIADKEGRIRNIYFPFDIE DTA SVATEMVAELD+TDQDVTRIADMIDGEIA LVP+W+PGPGI ETPRYAN+GFCHNC SNHTSSGS ++FLSN+P  KNLQ+L+CC+ GCASMHGRF E+T+Q+++                  L YQE+W QHESRELS + S QSHSD + E+LD+ +  +D+     E   + +A NS +NLSGSH FS I STY DL D +E EIQ E RWL+AK+QMELR+ +D Q    S SS++   EH   NG LS  ++ TL+G NN   S    ++    SPN      ++CE + SP             GSLLP SL RTVSLPVDAVD+
Sbjct:    1 MNGVTHLEPDESEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYQGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCRQILSGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYRVKDPEVRQFVEKCLVTVSLRLSARELLNDPFLQIDDYEYDLKTVENG-ELDEFGSLMRQPFFDLHRSYSNFSNEYSNGFGY--EGDWGPHPAEIEPSGIELFEYHDDDEPSEDVDISIKGKRKDDGGIFLRLRIADKEGRIRNIYFPFDIELDTAISVATEMVAELDMTDQDVTRIADMIDGEIASLVPEWRPGPGIDETPRYANEGFCHNCVSNHTSSGSFLDFLSNNPGNKNLQLLECCRHGCASMHGRFGEITFQSED------------------LQYQELWNQHESRELSPVESDQSHSDEQCEQLDKPIPAKDKAQDVWEKKFSPNAANSLRNLSGSHDFSTIRSTYCDLEDDYEKEIQKELRWLRAKYQMELRDHKDGQFGQCSHSSNS---EHRTENGFLSPSLTETLKGGNNGTRSHPHVHES---SPNSDTQRAQNCEAIESPG-----------EGSLLPHSLHRTVSLPVDAVDI 698          

Query:    1 MNGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEI-QEFRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSC-------------EVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            M+G+ + +   SEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKH+NIMKFYTSWVD ANRNINFVTEMFTSGTL+QYRLKHKRVNIRAVKHWCRQILRGL YLHSH+PPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHA HCVGTPEFMAPEVY EAYNELVDIYSFGMCILEM+TFEYPYSECTHPAQIYKKV+SGKKPDALYKVKDPEVRQF++KCLAT S RLSA ELLND FL++D  ++DLRPVDYGR +DD+ PL+RQP  ELHR               ++ +E GYHP+D E++GIELF          VDISIKGK  EDGGIFLRLRIADKEGRIRNIYFPFD+ETDTA SVATEMVAELD+TDQDVTRIADMIDGEIA LVP+W+PGPGI ETPR+ANQ +CHNCA +  +S S    L N    KN +V QCC    ASMHGRFEE+ YQADES HH  E APN SS    L+Y EIWG HESRELSS+ S QSHSD +YEK D+ +T  D +++ +ES  A +   + ++L  S SFS  PS      D +EN++ QE RW+KAK+Q+EL +LRDQQ+ L SKSS +  K+ ++ N         T +G +N +L  S + D    S + H  +N SC             + + S   E   T K+ C GSLLP SL RT+SLPVDAV +
Sbjct:    1 MDGVSDLELDCSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDIANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCRQILRGLHYLHSHEPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHADHCVGTPEFMAPEVYAEAYNELVDIYSFGMCILEMITFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVRQFIDKCLATVSYRLSAAELLNDPFLRVDNGEYDLRPVDYGRGLDDVCPLIRQPYLELHRSDSSFCTGYPYDYSFEASSESGYHPIDNETNGIELFEYCEGEHSEDVDISIKGKMSEDGGIFLRLRIADKEGRIRNIYFPFDVETDTALSVATEMVAELDMTDQDVTRIADMIDGEIASLVPEWRPGPGIEETPRFANQSYCHNCAPSTYNSASNGLMLRNR-DGKNSEVAQCCGHRYASMHGRFEEIMYQADESGHHTAEEAPNVSSHPGGLNYPEIWGHHESRELSSMSSRQSHSDEDYEKTDRPLTDTDTKEMIMESKTAPNTRRTLRSLMNSLSFSETPSP----PDINENDVQQEMRWIKAKYQLELNKLRDQQLNLSSKSSSSEDKQQKMEN--------ETPRGNHNQILDSS-SRDTNRSSTDSHVYINNSCYSTDVPKQRARNRKAVESSIVEKVATAKNACNGSLLPSSLHRTISLPVDAVHI 734          

Query:    1 MNGLVEPDYSD-SEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEIQE-FRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQ----------RNLSPNFHANLNKSCEV-MVSPNAED---EVTGKSFCT-GSLLPQSLRRTVSLPVDAVDV 2202
            MNG++ P+  D SEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKT+KH NIMKFYTSWVDTANRNINFVTEMFTSGTL+QYR KHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEE YNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKV+SGKKPDALYKVKDPEVR+FVEKCLA+ SLRLSARELL D FL+ID+C+ DLRP++  R+ DDM PLLRQP  E H                D+ N WGY P++ E +GIELF          VDISIKGKRRED GIFLRLRIADKE  IRNIYFPFDIE DTA SVATEMVAELDITDQDVT+IADMIDGEIA LVP+W+PGPGI ETP +A    CHNC SNHTS+GS+M+ L+N+P AKNLQ+ Q C  GCA+MHGRFEE+TYQ D ++HH+ EG      QS+ LH  EIW +HESRELSS+ SG+S SD EYEK++  + ++DE+                    GS + +V+ S   +  + +ENEIQ+  RWLKAKHQME+R LRD Q+   SK S   +++ +  N  L S +S+T QG NN +  KS AYD+             SP+   +  ++CE    S +AED    VT KSF T GSLLP  + RT+SLPVDAVD+
Sbjct:    1 MNGVINPEADDYSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTMKHNNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRQKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVREFVEKCLASVSLRLSARELLQDPFLRIDDCESDLRPIECRREPDDMVPLLRQPFLEYHHSNNSFSNGYSNAVDFDAHNGWGYQPLEMEPTGIELFEYHEDEHPANVDISIKGKRREDDGIFLRLRIADKEDHIRNIYFPFDIEMDTALSVATEMVAELDITDQDVTKIADMIDGEIASLVPEWKPGPGIEETPCFATLNLCHNCVSNHTSNGSLMDILANNPGAKNLQIFQ-CSNGCAAMHGRFEEITYQVDGADHHIPEG------QSEELHCTEIWDKHESRELSSVSSGESPSDEEYEKINHSI-IKDER--------------------GSGTGNVVASNVKNSINDYENEIQQVLRWLKAKHQMEMRGLRDLQLGFASKPSSLDNRQLKPDNEGLFSTLSNTSQGHNNGLFLKSSAYDKHFTSNCATQVNKCSPDLVTHGARNCEANKGSRSAEDMVHVVTAKSFYTAGSLLPCPIHRTMSLPVDAVDI 723          

Query:    1 MNGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELF-XXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGS-GQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDL-SDTHENEIQ-EFRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNV-------------MLSKSCAYDQRNLSPNFHANLNKSCEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            MNG+   +  DSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEY+GIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTL+QYRLKHKRVNIRAVKHWC QILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEE+YNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKV+SGKKPDALYKVKDPEVRQFV+KCLAT SLRLSA+ELL+D FLQID+ ++DLRPVD G ++ D GPL+RQPL++LHR                 + +  YHPVD E  GIELF           VDISIKGK+++DG IFLRLRI+DKEGR+RNIYFPFDIE DTA SVATEMVAELDITDQDVT IADMIDGEIA LVP+WQ GPGIVETPR+ANQGFC NC SNHTSSGS+M+FLS++    +LQ+ +CCK GCAS HGRFEE+T+Q++E ++HV E   N ++ +D L Y  +W QHESRELS + S  QSHSD + E+LD+ ++ E +     ES    +A  S +  SG+  FS I S Y  L  D +E EIQ E RWLKA++ MELR L+DQQ+ +  KSS  G+ EH++   ++   ++ T +G ++V             + S+ C +     SP+  A + ++CE M SP     VT KSF +GSL P SL RTVSLPVDAVD+
Sbjct:    1 MNGVTHLEEDDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYQGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCIQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEESYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVRQFVDKCLATVSLRLSAKELLDDPFLQIDDYEYDLRPVDSG-ELGDFGPLIRQPLYDLHRSYSNFSNEYSNGFGY--EGDCYYHPVDNEPCGIELFEHHDDEEPSEHVDISIKGKKKDDGSIFLRLRISDKEGRVRNIYFPFDIEMDTAISVATEMVAELDITDQDVTSIADMIDGEIASLVPEWQSGPGIVETPRFANQGFCRNCVSNHTSSGSLMDFLSHNQG--SLQLPECCKHGCASTHGRFEEITFQSEEYDNHVRENM-NIANIADGLQYLGLWNQHESRELSPVESDDQSHSDEQNEQLDKSISAEGQGHNICESKFPPNAIISPRYSSGTRDFSNIRSLYCGLDGDGYEKEIQKELRWLKARYLMELRGLKDQQLGITDKSSRGGNGEHKIDYAIMLPSLTETFKGADSVIRLQSVINNWSSDLSSRPCVHKS---SPDSDAKMAENCEAMGSPGEGMMVTAKSFYSGSLFPHSLHRTVSLPVDAVDI 742          

Query:  106 KTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEIQE-FRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQ----------RNLSPNFHANLNKSCEV-MVSPNAED---EVTGKSFCT-GSLLPQSLRRTVSLPVDAVDV 2202
            K  YRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKT+KH NIMKFYTSWVDTANRNINFVTEMFTSGTL+QYR KHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEE YNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKV+SGKKPDALYKVKDPEVR+FVEKCLA+ SLRLSARELL D FL+ID+C+ DLRP++  R+ DDM PLLRQP  E H                D+ N WGY P++ E +GIELF          VDISIKGKRRED GIFLRLRIADKE  IRNIYFPFDIE DTA SVATEMVAELDITDQDVT+IADMIDGEIA LVP+W+PGPGI ETP +A    CHNC SNHTS+GS+M+ L+N+P AKNLQ+ Q C  GCA+MHGRFEE+TYQ D ++HH+ EG      QS+ LH  EIW +HESRELSS+ SG+S SD EYEK++  + ++DE+      N AS+  NS  +L    S S IPS    LSD +ENEIQ+  RWLKAKHQME+R LRD Q+   SK S   +++ +  N  L S +S+T QG NN +  KS AYD+             SP+   +  ++CE    S +AED    VT KSF T GSLLP  + RT+SLPVDAVD+
Sbjct:   47 KKSYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTMKHNNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRQKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVREFVEKCLASVSLRLSARELLQDPFLRIDDCESDLRPIECRREPDDMVPLLRQPFLEYHHSNNSFSNGYSNAVDFDAHNGWGYQPLEMEPTGIELFEYHEDEHPANVDISIKGKRREDDGIFLRLRIADKEDHIRNIYFPFDIEMDTALSVATEMVAELDITDQDVTKIADMIDGEIASLVPEWKPGPGIEETPCFATLNLCHNCVSNHTSNGSLMDILANNPGAKNLQIFQ-CSNGCAAMHGRFEEITYQVDGADHHIPEG------QSEELHCTEIWYKHESRELSSVSSGESPSDEEYEKINHSI-IKDERG-SGTGNVASNVKNSISHLRNPSSSSAIPSMSCALSDDYENEIQQVLRWLKAKHQMEMRGLRDLQLGFASKPSSLDNRQLKPDNEGLFSTLSNTSQGHNNGLFLKSSAYDKHFTSNCATQVNKCSPDLVTHGARNCEANKGSRSAEDMVHVVTAKSFYTAGSLLPCPIHRTMSLPVDAVDI 752          

Query:    1 MNGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQA-DESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEIQ-EFRWLKAKHQMELRELRDQQIRLVSKSSDNGSK---EHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSCEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            MN + + +  DS+FVEVDPTGRYGRY+EILGKGASKTVYRAFDEY+GIEVAWNQ+KLYDFLQ+PEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTE+FTSGTL+QYRLKHKRVNIRAVKHWCRQIL+GL YLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEE YNELVDIYSFGMC+LEMVTFEYPYSEC+HPAQIYKKV SGKKPDALYKVKDPEVR+FVEKCLATASLRLSARELL+D FL+ID+ ++DL  VD G +  D+GPL+ Q  F + R               +   +W   P + E  GIELF          VDISIKGKR++DGGIFLRLRIADKE  IRNIYFPFDIE DTA SVATEMVAELDITDQDVT IA MIDGEIA LVP+W+PGPGI ET  Y+NQ FC NC SNHT+     + L  + SAKNL +LQCC  GCASMHGRFEE+T+Q+ D  + HV+E APN SS+SD L YQE W QHESRELS + S +SHSD +YE LD+   +ED+++   E++ A +AGNS K+LSG+H  S I S Y  + + +E EIQ E RWLKAK+QMEL EL+D+Q+ + +KS     K   E E  NG  + +     +  ++   S+     ++   PN      ++C V+ S   ED  T KSF T   LP +L RT+SLPVDAVDV
Sbjct:    1 MNCVTQLETDDSDFVEVDPTGRYGRYHEILGKGASKTVYRAFDEYQGIEVAWNQIKLYDFLQNPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTELFTSGTLRQYRLKHKRVNIRAVKHWCRQILQGLHYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEEYNELVDIYSFGMCVLEMVTFEYPYSECSHPAQIYKKVSSGKKPDALYKVKDPEVREFVEKCLATASLRLSARELLDDPFLRIDDDEYDLGSVDVG-EFGDLGPLVSQSFFSIDRSYSNISTEYSNGFGYEV--DWYSQPTEIE-HGIELFECHDDEPSKDVDISIKGKRKDDGGIFLRLRIADKEDHIRNIYFPFDIELDTALSVATEMVAELDITDQDVTSIAHMIDGEIASLVPEWRPGPGIDETINYSNQSFCDNCVSNHTTD---TDSLLRNQSAKNLHLLQCCMHGCASMHGRFEEITFQSEDYDDIHVSEDAPNISSKSDFLQYQESWNQHESRELSPVESTRSHSDEQYELLDKSFLIEDKREGIRENSFAPNAGNSLKDLSGNHYLSTIGSLYCGVENDYEKEIQHELRWLKAKYQMELWELKDKQLGVEAKSPHIEHKTPPETETVNGFDNGIHFHNYKDCDSSYNSR-----EQKSHPNLDTRRVQNCGVICS-KEEDMATAKSFYTRLFLPDTLHRTISLPVDAVDV 726          

Query:   13 VEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQ-GFCHNCASNHTSSGSMMEFLS-NHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEI-QEFRWLKAKHQMELRELRDQQI----RLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKS--CAYDQRNLSPNFHANLNKSC------------EVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVD 2199
            +EPDYS  EFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKL DFLQSPE+LERLYCEIHLLKTLKH NIMKFYTSWVD ANRNINFVTEMFTSGTL+QYRLKH+RVNIRAVKHWCRQILRGLLYLH+H PPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEE YNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKV+SGKKPDALYKVKDPEVRQFVEKCLAT +LRLSARELL D FLQ D+   DLRP++Y R + ++GPL R P + +H                + +N    HPV+ E + I+LF          VDISI+G++R+D GIFLRLRI+DKEGR+RNIYFPFD+ETDTA SVA EMV+ELDITDQDVT+IADMID EIA LVP W+ G GI E+  Y +   FCH+CASN    GS ++++S N+P  KNLQVLQC +QGCA++HGRFEE+TY+ + SE  VTEGAP  SSQSD + Y +IW Q E  ELSS GS +  SD E+E LD+ +  +DE+ + +++   S+A NS   L                 D +ENEI QE RWLKAK+QM+LRELRDQQ+    + +S + ++ S EH   N V  S +S+ L+G +N    KS  C    ++ +  F  +  + C             V  S + ED VT KSF TG+LLPQSL R  SLPVDAVD
Sbjct:    7 LEPDYS--EFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLNDFLQSPEELERLYCEIHLLKTLKHNNIMKFYTSWVDPANRNINFVTEMFTSGTLRQYRLKHRRVNIRAVKHWCRQILRGLLYLHNHKPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVRQFVEKCLATVTLRLSARELLKDPFLQSDDYGSDLRPIEYQRDLGEVGPLPRLPHYGIHHSYSSLRNEYSGYPDFEPENGLDCHPVEFERNEIDLFTYQEDEHLENVDISIEGRKRDDHGIFLRLRISDKEGRVRNIYFPFDMETDTALSVAMEMVSELDITDQDVTKIADMIDDEIASLVPGWKMGLGIEESQNYGHDASFCHHCASN----GSPLDYVSPNNPGTKNLQVLQCSRQGCAAVHGRFEEITYRVEGSEQCVTEGAPVVSSQSDGMQYADIWAQREGPELSSEGSREIQSDEEHESLDKSIYGKDERVINIDNQSESNAKNSFAPL-----------------DDYENEIRQELRWLKAKYQMQLRELRDQQLGAKPKWLSLTPNSDSMEHSRDNKVSPSSLSTPLEGEDNDPPLKSFPCG---KHFNSFFPVDTERGCANLAYRRPHNREPVSESCSPEDMVTAKSFFTGTLLPQSLHRATSLPVDAVD 730          

Query:   76 YNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQA-DESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEIQ-EFRWLKAKHQMELRELRDQQIRLVSKSSDNGSK---EHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSCEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            Y+EILGKGASKTVYRAFDEY+GIEVAWNQ+KLYDFLQ+PEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTE+FTSGTL+QYRLKHKRVNIRAVKHWCRQIL+GL YLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEE YNELVDIYSFGMC+LEMVTFEYPYSEC+HPAQIYKKV SGKKPDALYKVKDPEVR+FVEKCLATASLRLSARELL+D FL+ID+ ++DL  VD G +  D+GPL+ Q  F + R               +   +W   P + E  GIELF          VDISIKGKR++DGGIFLRLRIADKE  IRNIYFPFDIE DTA SVATEMVAELDITDQDVT IA MIDGEIA LVP+W+PGPGI ET  Y+NQ FC NC SNHT+     + L  + SAKNL +LQCC  GCASMHGRFEE+T+Q+ D  + HV+E APN SS+SD L YQE W QHESRELS + S +SHSD +YE LD+   +ED+++   E++ A +AGNS K+LSG+H  S I S Y  + + +E EIQ E RWLKAK+QMEL EL+D+Q+ + +KS     K   E E  NG  + +     +  ++   S+     ++   PN      ++C V+ S   ED  T KSF T   LP +L RT+SLPVDAVDV
Sbjct:   12 YHEILGKGASKTVYRAFDEYQGIEVAWNQIKLYDFLQNPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTELFTSGTLRQYRLKHKRVNIRAVKHWCRQILQGLHYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEEYNELVDIYSFGMCVLEMVTFEYPYSECSHPAQIYKKVSSGKKPDALYKVKDPEVREFVEKCLATASLRLSARELLDDPFLRIDDDEYDLGSVDVG-EFGDLGPLVSQSFFSIDRSYSNISTEYSNGFGYEV--DWYSQPTEIE-HGIELFECHDDEPSKDVDISIKGKRKDDGGIFLRLRIADKEDHIRNIYFPFDIELDTALSVATEMVAELDITDQDVTSIAHMIDGEIASLVPEWRPGPGIDETINYSNQSFCDNCVSNHTTD---TDSLLRNQSAKNLHLLQCCMHGCASMHGRFEEITFQSEDYDDIHVSEDAPNISSKSDFLQYQESWNQHESRELSPVESTRSHSDEQYELLDKSFLIEDKREGIRENSFAPNAGNSLKDLSGNHYLSTIGSLYCGVENDYEKEIQHELRWLKAKYQMELWELKDKQLGVEAKSPHIEHKTPPETETVNGFDNGIHFHNYKDCDSSYNSR-----EQKSHPNLDTRRVQNCGVICS-KEEDMATAKSFYTRLFLPDTLHRTISLPVDAVDV 712          

Query:    1 MNGL--VEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQP-----------------------LFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESS-GIELF------XXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYA----NQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIW---GQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHD-LSDTHENEI-QEFRWLKAKHQMELRELRDQQIRLVSKSSDNGSK-EHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSCEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVD 2199
            MN L  +EPDYS  EFVEVDPTGRYGRYNE+LGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTE+FTSGTL+QYRL+HKRVNIRA+KHWCRQILRGL YLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTF+YPYSECTHPAQIYKKV+SGKKPDALYKVKDPEV+ F+EKCLAT SLR+SARELL+D FL+ID+ + DLR VD     D +GPL RQP                        +  +                + QN W Y+P + E + GIELF                VDI+IKGKRR+DGG+FLRLRIADKEGR+RNIYFPFDIETDTA SVATEMVAELD+ D  VT+IA+MIDGEI+ LVP W+PGP   E    A        C+NC SN TS GS+M+FL  +P A    V+QCC+ GC   HGRFEE+T +  E                  +  +E+W    Q ESRELSSI SG +HS+ E E   + V  ED +++      +  AGN   ++SGS SFS +PS Y D  S+  EN++ QE RWLKAK Q+ELR+++D+Q++  ++  ++G + E    +G L S                                        VS    +E T K      L+P+ L+RT SLPVDA+D
Sbjct:    1 MNNLSYLEPDYS--EFVEVDPTGRYGRYNEVLGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTELFTSGTLRQYRLRHKRVNIRAMKHWCRQILRGLHYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFDYPYSECTHPAQIYKKVMSGKKPDALYKVKDPEVKCFIEKCLATVSLRVSARELLDDPFLRIDDGEFDLRSVD---MEDSVGPLYRQPHHLPDYYNYPSNSSSLNRQYSNGNYPSNSSSLNRQYSNGYNSHHEYQNGWAYNPAETEETHGIELFESRNNDDQEEEKKSGNVDITIKGKRRDDGGLFLRLRIADKEGRVRNIYFPFDIETDTALSVATEMVAELDMDDHGVTKIANMIDGEISSLVPSWRPGPEFEECLAAAAAANAASICNNCVSNRTSMGSVMDFLRTNPGA---NVIQCCRNGCGETHGRFEEITIRETE------------------VRLRELWKLQQQQESRELSSIDSGHNHSEEEEE---EEVLYEDPENMF-----SCEAGNEINHISGSGSFSFMPSKYCDEPSEKTENQVQQELRWLKAKCQIELRDIQDEQLK--TRWPESGEEVEISPKDGFLGS----------------------------------------VSGLGREEDTVKEMFGERLVPKCLKRTTSLPVDAID 699          

Query:   37 EFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXD----SQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTE-GAPNESSQSDCLHYQEIWGQHES----------RELSSIGSGQSHSDG----EYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEIQEFRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSCEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVD 2199
            E+ EVDPTGRYGRYN++LGKGASKTVYRAFDEY+G+EVAWNQVKL+DFLQSPEDLERLYCEIHLLKTLKH+NIMKFYTSWVD + RNINF+TEMFTSGTL+QYR KH RVNI AVKHWCRQIL GLLYLHSHDPP+IHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHA HCVGTPEFMAPEVYEE YNELVDIYSFGMC+LEMVTFEYPYSECTHP QIYKKV+SG KP+ALYKVKDP VRQFVEKCLATAS RLSARELL D FLQ+D+        DY      +   LRQP  E H                D    +++ W     D ++ GI+LF          VDI+IKG++ EDG IFLRLRIAD +G +RNIYFPFDIE DTA SVATEMVAELDITD +VTRIA+MIDGE++ LVPDW+PGPGI E+    +  +CHNC SN +S GS+  ++S+  +A+  Q        CA +HGRFEE+T+QA+  +  + + G  ++       H ++    H +          R+     S Q  S      EY+   Q    + + ++++    A    +  + +  S  F  +       S    N++Q F   K           +   R+ +     G+++ E    +                   + AY  R+  P   A   + CEV    + +   T +S+ TG+ LP +L RT S+ ++AVD
Sbjct:   16 EYAEVDPTGRYGRYNDVLGKGASKTVYRAFDEYQGMEVAWNQVKLHDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDVSRRNINFITEMFTSGTLRQYRQKHMRVNIWAVKHWCRQILSGLLYLHSHDPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAVHCVGTPEFMAPEVYEEEYNELVDIYSFGMCVLEMVTFEYPYSECTHPVQIYKKVISGTKPEALYKVKDPMVRQFVEKCLATASRRLSARELLKDPFLQVDDLVFCPGDGDY-----SLMNYLRQPYLE-HAYSNVSMMSNGLSESIDEDTPTEDRWDCEDDDIKADGIDLFNGHEDEPLGNVDITIKGRKSEDGSIFLRLRIADNDGHVRNIYFPFDIEADTALSVATEMVAELDITDHEVTRIAEMIDGEVSALVPDWRPGPGIEES---QDTTYCHNCGSNVSSCGSLYAYMSS--AARGCQ--------CAELHGRFEEITFQANGEQTDLQDSGGSSDDGGGQTQHVKDQEAVHSNGFVQMGRRGPRDQFCFSSFQEQSCSPRHYEYDTSLQAKGFDMKHEVKMAKYKARKMAHLRRAIHPSLDFDNLNGERRMKSSL--NKLQSFHIGK-----------NHNFRIPTCERSPGARDAEEDPDIF------------------NLAYHSRHPDPG--AQRARHCEVDAQSSPDLMFTARSYYTGAQLPTNLPRTKSVTLNAVD 703          

Query:   37 EFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXD----SQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTE-GAPNESSQSDCLHYQEIWGQHES 1617
            E+ EVDPTGRYGRYN++LGKGASKTVYRAFDEY+G+EVAWNQVKL+DFLQSPEDLERLYCEIHLLKTLKH+NIMKFYTSWVD + RNINF+TEMFTSGTL+QYR KH RVNI AVKHWCRQIL GLLYLHSHDPP+IHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHA HCVGTPEFMAPEVYEE YNELVDIYSFGMC+LEMVTFEYPYSECTHP QIYKKV+SG KP+ALYKVKDP VRQFVEKCLATAS RLSARELL D FLQ+D+        DY      +   LRQP  E H                D    +++ W     D ++ GI+LF          VDI+IKG++ EDG IFLRLRIAD +G +RNIYFPFDIE DTA SVATEMVAELDITD +VTRIA+MIDGE++ LVPDW+PGPGI E+    +  +CHNC SN +S GS+  ++S+  +A+  Q        CA +HGRFEE+T+QA+  +  + + G  ++       H ++    H +
Sbjct:   16 EYAEVDPTGRYGRYNDVLGKGASKTVYRAFDEYQGMEVAWNQVKLHDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDVSRRNINFITEMFTSGTLRQYRQKHMRVNIWAVKHWCRQILSGLLYLHSHDPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAVHCVGTPEFMAPEVYEEEYNELVDIYSFGMCVLEMVTFEYPYSECTHPVQIYKKVISGTKPEALYKVKDPMVRQFVEKCLATASRRLSARELLKDPFLQVDDLVFCPGDGDY-----SLMNYLRQPYLE-HAYSNVSMMSNGLSESIDEDTPTEDRWDCEDDDIKADGIDLFNGHEDEPLGNVDITIKGRKSEDGSIFLRLRIADNDGHVRNIYFPFDIEADTALSVATEMVAELDITDHEVTRIAEMIDGEVSALVPDWRPGPGIEES---QDTTYCHNCGSNVSSCGSLYAYMSS--AARGCQ--------CAELHGRFEEITFQANGEQTDLQDSGGSSDDGGGQTQHVKDQEAVHSN 528          

Query:    1 MNGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGR-QIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVD-AESSGIELF-------XXXXXXXXXXVDISIKGKRREDG-GIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQ 1518
            MN L   +   SE+VEVDPTGRYGRYNE+LGKG+SKTVYR FDEY+GIEVAWNQVKLYDFLQSP++LERLYCEIHLLKTLKHK+IMKFY SWVDT NRNINFVTEMFTSGTL+QYRLKHKRVNIRAVK+WCRQILRGL YLH+HDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAA L+ SHAAHCVGTPEFMAPEVY+E YN+LVDIYSFGMC+LEMVTF+YPYSEC+HPAQIYK+V+SGKKPD L KVKDPEVR F+EKCLAT SLRLSA ELL+D FL IDE   D+R V+  +  ID+ G  LR      H                 +QN+W Y+  +  ES  I+L                  VDISIKGKRR++G G+FLRL+  +KEG +RNIYFPFDIETDTA SVA EMV EL++ D+DVT+IA+MIDGEIA LVP+W                FC +  SN +S GS+M+F            +QC + GC   HGRFEE+T++
Sbjct:    2 MNNLSHLESDYSEYVEVDPTGRYGRYNEVLGKGSSKTVYRGFDEYQGIEVAWNQVKLYDFLQSPQELERLYCEIHLLKTLKHKSIMKFYASWVDTDNRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKNWCRQILRGLNYLHTHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAACLQHSHAAHCVGTPEFMAPEVYKEEYNQLVDIYSFGMCVLEMVTFDYPYSECSHPAQIYKRVISGKKPDGLDKVKDPEVRGFIEKCLATVSLRLSACELLDDHFLCIDE--SDMRRVESEKGLIDEAGTPLRHSYHIPHYSNGYYSLY--------NQNQWDYNGDETVESHEIDLLEFQNDDDEEEEDKRFGSVDISIKGKRRDNGDGLFLRLKTVNKEGCVRNIYFPFDIETDTAISVAREMVEELEMDDRDVTKIANMIDGEIASLVPNWSI--------------FC-SSESNRSSVGSVMDF----------NEMQCGRDGCEEKHGRFEEITFE 482          

Query:   34 SEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECD-HDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDW----QPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEV 1509
            S FVE+DP+GRYGRY+EILGKGASKTVYRAFDEYEGIEVAWNQVKL +F ++PE+LE+ + EIHLLKTL H+NIMKFYTSWVDT N +INFVTE+FTSGTL+QYRL+H+RVNIRAVK WC+QIL+GLLYLHS  PP+IHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHA  CVGTPEFMAPEVY+E YNELVD+Y+FGMC+LEMVTF+YPYSECTHPAQIYKKV SGKKP+A Y VKDPEVR+FVEKCLA  + RL+A ELL D FLQ D  D   +RP+DY    D+ G  LR PL +                      +  YH    ESS I             VDISIKGKR  D GIFLRLRI+D EGRIRNIYFPF+   DTA+SVA EMV+ELDIT+QDV +IA+MID EIA LVPDW    +    +         GFC  CASN     ++     +H +       +   + C+S+HGRF ++
Sbjct:   12 SVFVEIDPSGRYGRYDEILGKGASKTVYRAFDEYEGIEVAWNQVKLRNFTRNPEELEKFFREIHLLKTLNHQNIMKFYTSWVDTNNLSINFVTELFTSGTLRQYRLRHRRVNIRAVKQWCKQILKGLLYLHSRSPPIIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAVRCVGTPEFMAPEVYDEEYNELVDVYAFGMCVLEMVTFDYPYSECTHPAQIYKKVTSGKKPEAFYLVKDPEVREFVEKCLANVTCRLTALELLQDPFLQDDNMDGFVMRPIDYYNGYDETGVFLRHPLID----------------------DPLYHD-QFESSQICEIDLFANDDEDHVDISIKGKRNGDDGIFLRLRISDAEGRIRNIYFPFETAIDTAWSVAVEMVSELDITNQDVAKIAEMIDAEIAALVPDWKNDTESSQNVNNNKNNNTAGFCGECASNGYIQETVSSGEKSHHNHHEFDSSE--DKSCSSVHGRFADM 483          

Query:   28 SDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFE-LHRXXXXXXXXXXXXXXXDSQNEWGYHPVDA--------------------ESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKE--GRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGI--------------VETPRYANQGFCHNC---ASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQA--DESEHHVTEGAPNESSQSDCLHYQEIWGQ 1608
            +++ + EVDPTGRYGR+NEILGKG+SK VYR FDE+ G+EVAWNQV+L D ++   +LER Y E+HLL  L+H+ I++ +  WVD   R +NFVTE+F SGTL+QYR +H+RV+  AV+ WC QIL GL YLH+H PP+IHRDLKCDNIF+NGNQGEVKIGDLGLAA  R    A CVGTPEFMAPEVY+E+Y+EL D+YSFGMC+LEMVT +YPYSEC++P QIYK+V+SG KP ALY+V DP VRQF+E+CLA A+ R +ARELL+D FL   E D      D G      G      ++  LH+                  N  G + VDA                    +    +            VDI+IKG+R +DGG++L LRIADK   GR R I F FD E DTA +VA EMVAELDITD +VTRIA +IDG++A LVP W+PGP                 + P  A    C NC   AS+ +S GS+++F+S+  +A+       C++ CA +HGRFEE+T+QA  DE E H+ +G+ +++  S+  H Q   G+
Sbjct:   20 AEAGYAEVDPTGRYGRFNEILGKGSSKIVYRGFDEWRGVEVAWNQVRLRDVVRGGGELERFYGEVHLLAALRHRGIVRLHAYWVDAPRRALNFVTELFVSGTLRQYRERHRRVSAAAVRRWCAQILDGLAYLHAHSPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAAFRRGGGHARCVGTPEFMAPEVYDESYDELADVYSFGMCVLEMVTLDYPYSECSNPIQIYKRVISGIKPAALYRVSDPVVRQFIERCLAPAARRPAARELLDDPFLLPLE-DDGFFSGDGGDGHGGFGVGYYNLMYNYLHQPACIDDHHACSNGGLSPSNSVGDNDVDAAVQRGDDDGDNWLRDIHMLFDEDDDDAAAADANERVGGVDITIKGRRTDDGGVYLGLRIADKNGTGRGRIICFRFDTEADTAMTVAAEMVAELDITDHEVTRIAQLIDGKVAALVPGWRPGPATDDDDDDDLVGGGDDPDAPGGAAAACCKNCRPAASSSSSCGSLVDFMSSAAAAER----HGCRR-CAELHGRFEEITFQADDDEEEQHL-QGSSSDTGGSN--HEQHAMGK 579          

Query:   28 SDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAH-CVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPL---FELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDW 1317
            ++ EF EVDPT RYGRY E+LGKGA KTVY+AFD+ EG+EVAWNQ+K+ D L++ +DLERL  E+ LLKTLKHKNI+KFY SW+D  N NINF+TE+FTSGTL+QYR+KHK+V++RA+K W RQIL GL+YLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLA IL  + +AH  +GTPEFMAPE+Y+E YNELVDIY+FGMC+LE+VTFEYPY EC++ AQIYKKV  G+KP +L K++DPEVR F+EKC+A AS RLSA+ELL D FL+ D+ +    P+    +  D        +   ++                     + + +  +D +++   +             I+++ + ++   IFL+LRIAD  G  +NI+FPFDIE DT+ SVATEMV +LD+TDQDVT IA+MID EI   +PDW
Sbjct:   14 TEPEFAEVDPTARYGRYTEVLGKGAFKTVYKAFDQLEGLEVAWNQIKVGDILRNNDDLERLRSEVRLLKTLKHKNIIKFYNSWLDKKNNNINFITEVFTSGTLRQYRIKHKKVDVRALKKWSRQILSGLVYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLATILDNARSAHSIIGTPEFMAPELYDEEYNELVDIYAFGMCLLELVTFEYPYCECSNAAQIYKKVSDGEKPSSLAKIEDPEVRFFIEKCIAKASQRLSAQELLMDPFLR-DDGEKIFYPLQSNTKASDGAGSSNSSMGYKYDRDASSMAIREHTGSFAEEHPSDRYIHSTMDPQAAAGRI-------------ITVESQMKDLNTIFLKLRIADSTGHAQNIHFPFDIEADTSISVATEMVVQLDLTDQDVTAIAEMIDAEIRAHIPDW 433          

Query:   40 FVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGK-RREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQ 1362
            +VE DP+GRYGR+ E+LGKGA KTVY+AFD+  G+EVAWNQVKL +  +SPE L+RLY E+HLLK L H++I+++ TSW+D   R  NF+TE+FTSGTL++YR K+++V+IRA+K W RQIL GL YLH HDPPVIHRDLKCDNIF+NG+ G+VKIGDLGLAAILR S  AH V GTPEFMAPE+YEE YNELVDIYSFGMC+LEM+T EYPYSECT+PAQIYKKV SGK PD+ + ++  E ++FV KCL T S RL A+ELL D FL   +               D+ PL R P                         +     + A  + +E             D+SI GK   ED  IFL+++I D +G +RNI FPF+I +DT   VA EMV EL+ITD D   IA MI+ EI+LLVP+W+     +    + ++
Sbjct:   15 YVETDPSGRYGRFREVLGKGAMKTVYKAFDQVLGMEVAWNQVKLNEVFRSPEPLQRLYSEVHLLKNLNHESIIRYCTSWIDVNRRTFNFITELFTSGTLREYRRKYQKVDIRAIKSWARQILNGLAYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQNAHSVIGTPEFMAPELYEEDYNELVDIYSFGMCVLEMLTGEYPYSECTNPAQIYKKVTSGKLPDSFHLIQHTEAQRFVGKCLETVSRRLPAKELLADPFLAATD-------------ERDLAPLFRLP------------------------QQLAIQNLAANGTVVE-HLPSTTDPTRTTDMSITGKMNSEDHTIFLQVQILDGDGHMRNIQFPFNILSDTPLEVALEMVKELEITDWDPLEIAAMIENEISLLVPNWRANDSSIRHESFGHE 419          

Query:    4 NGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDIS---------IKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQ 1320
            + +VEP   D E +E+DPT RY RY E++GKGASKTV++ FDE +GIEVAWNQV++ D LQSP+ LERLY E+ LLK+LKHKNI++FY SW+D  N+ +N +TE+FTSG+L+QYR KH++VN++AVK W RQIL GL YLHS DPP+IHRD+KCDNIFINGN GEVKIGDLGLA ++ +++A   +GTPEFMAPE+Y+E YNEL DIYSFGMC+LEMVTFEYPY EC + AQIYKKV SG KP +L KVKDPEV +F+EKCL  AS RLSA ELL D FL ++           G  +++  PL   P   + +               +++N      +D E + + +           +++          +KG+  ++  + L LRI D+ GR+RNI+F F  E DTA +V++EMV +L++TD++V  IA++ID  +  L+P+W+
Sbjct:    8 SAIVEPP--DPEVLEIDPTCRYIRYKEVIGKGASKTVFKGFDEVDGIEVAWNQVRIDDLLQSPDCLERLYSEVRLLKSLKHKNIIRFYNSWIDDKNKTVNIITELFTSGSLRQYRKKHRKVNMKAVKCWARQILTGLKYLHSQDPPIIHRDIKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFEYPYCECRNSAQIYKKVSSGIKPASLSKVKDPEVMKFIEKCLLPASERLSAEELLLDSFLNVN-----------GLVMNNPLPL---PDIVMPKEGSFGERCLMSEGPPNARNRTMSMNLD-EDNNLPIVISSNNSGTNCIEVRRAKRGNFFVLKGEENDENSVSLILRIVDENGRVRNIHFLFFQEGDTASNVSSEMVEQLELTDKNVKFIAELIDVLLVNLIPNWK 438          

Query:   31 DSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQ 1320
            D+E VEVDPT RY RYNE+LG+GA KTVY+AFDE EGIEVAW+QV++ + +QSP++LERLY E+HLLK+LKH+N+MKFY  WVD   + IN +TE+FTSG+L+QYR KH RV+++A+K+W RQ+LRGL YLH+H PP+IHRDLKCDNIF+NGN GEVKIGDLGLA ++    A   +GTPEFMAPE+Y+E Y+ELVDIYSFGMC+LEM T EYPYSECT+ AQI+KKV  G KP AL K+ + + +QF++KCL  AS RLSA+ELL D FL  D        V  G +     P  +     L                   +N+ G         G               ++ + G++ +D  + L LRIAD  G  RNI+F F +++DTA SVA EMV +L++ D DVT IAD ID  I  LVP  Q
Sbjct:   12 DAECVEVDPTRRYIRYNEVLGRGAMKTVYKAFDEVEGIEVAWSQVEIDEVMQSPDNLERLYSEVHLLKSLKHENVMKFYNYWVDDQKKTINVITELFTSGSLRQYRQKHPRVDLKAIKNWARQVLRGLDYLHTHQPPIIHRDLKCDNIFVNGNHGEVKIGDLGLATVMLTPRAKSVIGTPEFMAPELYDENYDELVDIYSFGMCMLEMFTLEYPYSECTNAAQIFKKVSKGVKPAALAKITNIQAKQFIDKCLVPASERLSAKELLQDPFLCSDNSS-----VLVGTKFPSSLP--KSVDVSLEALHMDVDTNESMCTSTCKRNDLG---------GPHRSVLEFTRTNKNTELKLTGEKLDDNSVSLVLRIADLCGHARNIHFLFYLDSDTAMSVAAEMVEQLELADCDVTFIADFIDLLIVNLVPGQQ 425          

Query:    1 MNGL--VEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQP-----------------------LFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESS-GIELF------XXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYA----NQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIW---GQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHD-LSDTHENEI-QEFRWLKAKHQMELRELRDQQIRLVSKSSDNGSK-EHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSCEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVD 2199
            MN L  +EPDYS  EFVEVDPTGRYGRYNE+LGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTE+FTSGTL+QYRL+HKRVNIRA+KHWCRQILRGL YLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTF+YPYSECTHPAQIYKKV+SGKKPDALYKVKDPEV+ F+EKCLAT SLR+SARELL+D FL+ID+ + DLR VD     D +GPL RQP                        +  +                + QN W Y+P + E + GIELF                VDI+IKGKRR+DGG+FLRLRIADKEGR+RNIYFPFDIETDTA SVATEMVAELD+ D  VT+IA+MIDGEI+ LVP W+PGP   E    A        C+NC SN TS GS+M+FL  +P A    V+QCC+ GC   HGRFEE+T +  E                  +  +E+W    Q ESRELSSI SG +HS+ E E   + V  ED +++      +  AGN   ++SGS SFS +PS Y D  S+  EN++ QE RWLKAK Q+ELR+++D+Q++  ++  ++G + E    +G L S                                        VS    +E T K      L+P+ L+RT SLPVDA+D
Sbjct:    1 MNNLSYLEPDYS--EFVEVDPTGRYGRYNEVLGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTELFTSGTLRQYRLRHKRVNIRAMKHWCRQILRGLHYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFDYPYSECTHPAQIYKKVMSGKKPDALYKVKDPEVKCFIEKCLATVSLRVSARELLDDPFLRIDDGEFDLRSVD---MEDSVGPLYRQPHHLPDYYNYPSNSSSLNRQYSNGNYPSNSSSLNRQYSNGYNSHHEYQNGWAYNPAETEETHGIELFESRNNDDQEEEKKSGNVDITIKGKRRDDGGLFLRLRIADKEGRVRNIYFPFDIETDTALSVATEMVAELDMDDHGVTKIANMIDGEISSLVPSWRPGPEFEECLAAAAAANAASICNNCVSNRTSMGSVMDFLRTNPGA---NVIQCCRNGCGETHGRFEEITIRETE------------------VRLRELWKLQQQQESRELSSIDSGHNHSEEEEE---EEVLYEDPENMF-----SCEAGNEINHISGSGSFSFMPSKYCDEPSEKTENQVQQELRWLKAKCQIELRDIQDEQLK--TRWPESGEEVEISPKDGFLGS----------------------------------------VSGLGREEDTVKEMFGERLVPKCLKRTTSLPVDAID 699          

Query:  112 VYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQP-----------------------LFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESS-GIELF------XXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYA----NQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIW---GQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHD-LSDTHENEI-QEFRWLKAKHQMELRELRDQQIRLVSKSSDNGSK-EHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSCEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVD 2199
            +YRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTE+FTSGTL+QYRL+HKRVNIRA+KHWCRQILRGL YLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTF+YPYSECTHPAQIYKKV+SGKKPDALYKVKDPEV+ F+EKCLAT SLR+SARELL+D FL+ID+ + DLR VD     D +GPL RQP                        +  +                + QN W Y+P + E + GIELF                VDI+IKGKRR+DGG+FLRLRIADKEGR+RNIYFPFDIETDTA SVATEMVAELD+ D  VT+IA+MIDGEI+ LVP W+PGP   E    A        C+NC SN TS GS+M+FL  +P A    V+QCC+ GC   HGRFEE+T +  E                  +  +E+W    Q ESRELSSI SG +HS+ E E   + V  ED +++      +  AGN   ++SGS SFS +PS Y D  S+  EN++ QE RWLKAK Q+ELR+++D+Q++  ++  ++G + E    +G L S                                        VS    +E T K      L+P+ L+RT SLPVDA+D
Sbjct:   15 LYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTELFTSGTLRQYRLRHKRVNIRAMKHWCRQILRGLHYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFDYPYSECTHPAQIYKKVMSGKKPDALYKVKDPEVKCFIEKCLATVSLRVSARELLDDPFLRIDDGEFDLRSVD---MEDSVGPLYRQPHHLPDYYNYPSNSSSLNRQYSNGNYPSNSSSLNRQYSNGYNSHHEYQNGWAYNPAETEETHGIELFESRNNDDQEEEKKSGNVDITIKGKRRDDGGLFLRLRIADKEGRVRNIYFPFDIETDTALSVATEMVAELDMDDHGVTKIANMIDGEISSLVPSWRPGPEFEECLAAAAAANAASICNNCVSNRTSMGSVMDFLRTNPGA---NVIQCCRNGCGETHGRFEEITIRETE------------------VRLRELWKLQQQQESRELSSIDSGHNHSEEEEE---EEVLYEDPENMF-----SCEAGNEINHISGSGSFSFMPSKYCDEPSEKTENQVQQELRWLKAKCQIELRDIQDEQLK--TRWPESGEEVEISPKDGFLGS----------------------------------------VSGLGREEDTVKEMFGERLVPKCLKRTTSLPVDAID 676          

Query:    1 MNGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGR-QIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVD-AESSGIELF-------XXXXXXXXXXVDISIKGKRREDG-GIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQ 1518
            MN L   +   SE+VEVDPTGRYGRYNE+LGKG+SKTVYR FDEY+GIEVAWNQVKLYDFLQSP++LERLYCEIHLLKTLKHK+IMKFY SWVDT NRNINFVTEMFTSGTL+QYRLKHKRVNIRAVK+WCRQILRGL YLH+HDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAA L+ SHAAHCVGTPEFMAPEVY+E YN+LVDIYSFGMC+LEMVTF+YPYSEC+HPAQIYK+V+SGKKPD L KVKDPEVR F+EKCLAT SLRLSA ELL+D FL IDE   D+R V+  +  ID+ G  LR      H                 +QN+W Y+  +  ES  I+L                  VDISIKGKRR++G G+FLRL+  +KEG +RNIYFPFDIETDTA SVA EMV EL++ D+DVT+IA+MIDGEIA LVP+W                FC +  SN +S GS+M+F            +QC + GC   HGRFEE+T++
Sbjct:    2 MNNLSHLESDYSEYVEVDPTGRYGRYNEVLGKGSSKTVYRGFDEYQGIEVAWNQVKLYDFLQSPQELERLYCEIHLLKTLKHKSIMKFYASWVDTDNRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKNWCRQILRGLNYLHTHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAACLQHSHAAHCVGTPEFMAPEVYKEEYNQLVDIYSFGMCVLEMVTFDYPYSECSHPAQIYKRVISGKKPDGLDKVKDPEVRGFIEKCLATVSLRLSACELLDDHFLCIDE--SDMRRVESEKGLIDEAGTPLRHSYHIPHYSNGYYSLY--------NQNQWDYNGDETVESHEIDLLEFQNDDDEEEEDKRFGSVDISIKGKRRDNGDGLFLRLKTVNKEGCVRNIYFPFDIETDTAISVAREMVEELEMDDRDVTKIANMIDGEIASLVPNWSI--------------FC-SSESNRSSVGSVMDF----------NEMQCGRDGCEEKHGRFEEITFE 482          

Query:   34 SEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECD-HDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDW----QPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEV 1509
            S FVE+DP+GRYGRY+EILGKGASKTVYRAFDEYEGIEVAWNQVKL +F ++PE+LE+ + EIHLLKTL H+NIMKFYTSWVDT N +INFVTE+FTSGTL+QYRL+H+RVNIRAVK WC+QIL+GLLYLHS  PP+IHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHA  CVGTPEFMAPEVY+E YNELVD+Y+FGMC+LEMVTF+YPYSECTHPAQIYKKV SGKKP+A Y VKDPEVR+FVEKCLA  + RL+A ELL D FLQ D  D   +RP+DY    D+ G  LR PL +                      +  YH    ESS I             VDISIKGKR  D GIFLRLRI+D EGRIRNIYFPF+   DTA+SVA EMV+ELDIT+QDV +IA+MID EIA LVPDW    +    +         GFC  CASN     ++     +H +       +   + C+S+HGRF ++
Sbjct:   12 SVFVEIDPSGRYGRYDEILGKGASKTVYRAFDEYEGIEVAWNQVKLRNFTRNPEELEKFFREIHLLKTLNHQNIMKFYTSWVDTNNLSINFVTELFTSGTLRQYRLRHRRVNIRAVKQWCKQILKGLLYLHSRSPPIIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAVRCVGTPEFMAPEVYDEEYNELVDVYAFGMCVLEMVTFDYPYSECTHPAQIYKKVTSGKKPEAFYLVKDPEVREFVEKCLANVTCRLTALELLQDPFLQDDNMDGFVMRPIDYYNGYDETGVFLRHPLID----------------------DPLYHD-QFESSQICEIDLFANDDEDHVDISIKGKRNGDDGIFLRLRISDAEGRIRNIYFPFETAIDTAWSVAVEMVSELDITNQDVAKIAEMIDAEIAALVPDWKNDTESSQNVNNNKNNNTAGFCGECASNGYIQETVSSGEKSHHNHHEFDSSE--DKSCSSVHGRFADM 483          

Query:  379 VKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQP-----------------------LFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESS-GIELF------XXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYA----NQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIW---GQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHD-LSDTHENEI-QEFRWLKAKHQMELRELRDQQIRLVSKSSDNGSK-EHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSCEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVD 2199
            +KHWCRQILRGL YLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTF+YPYSECTHPAQIYKKV+SGKKPDALYKVKDPEV+ F+EKCLAT SLR+SARELL+D FL+ID+ + DLR VD     D +GPL RQP                        +  +                + QN W Y+P + E + GIELF                VDI+IKGKRR+DGG+FLRLRIADKEGR+RNIYFPFDIETDTA SVATEMVAELD+ D  VT+IA+MIDGEI+ LVP W+PGP   E    A        C+NC SN TS GS+M+FL  +P A    V+QCC+ GC   HGRFEE+T +  E                  +  +E+W    Q ESRELSSI SG +HS+ E E   + V  ED +++      +  AGN   ++SGS SFS +PS Y D  S+  EN++ QE RWLKAK Q+ELR+++D+Q++  ++  ++G + E    +G L S                                        VS    +E T K      L+P+ L+RT SLPVDA+D
Sbjct:    1 MKHWCRQILRGLHYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFDYPYSECTHPAQIYKKVMSGKKPDALYKVKDPEVKCFIEKCLATVSLRVSARELLDDPFLRIDDGEFDLRSVD---MEDSVGPLYRQPHHLPDYYNYPSNSSSLNRQYSNGNYPSNSSSLNRQYSNGYNSHHEYQNGWAYNPAETEETHGIELFESRNNDDQEEEKKSGNVDITIKGKRRDDGGLFLRLRIADKEGRVRNIYFPFDIETDTALSVATEMVAELDMDDHGVTKIANMIDGEISSLVPSWRPGPEFEECLAAAAAANAASICNNCVSNRTSMGSVMDFLRTNPGA---NVIQCCRNGCGETHGRFEEITIRETE------------------VRLRELWKLQQQQESRELSSIDSGHNHSEEEEE---EEVLYEDPENMF-----SCEAGNEINHISGSGSFSFMPSKYCDEPSEKTENQVQQELRWLKAKCQIELRDIQDEQLK--TRWPESGEEVEISPKDGFLGS----------------------------------------VSGLGREEDTVKEMFGERLVPKCLKRTTSLPVDAID 573          

Query:   34 SEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCV--------------------------------GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECD-HDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKE---------------------------GRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDW----QPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEV 1509
            S FVE+DP+GRYGRY+EILGKGASKTVYRAFDEYEGIEVAWNQVKL +F ++PE+LE+ + EIHLLKTL H+NIMKFYTSWVDT N +INFVTE+FTSGTL+QYRL+H+RVNIRAVK WC+QIL+GLLYLHS  PP+IHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHA  CV                                GTPEFMAPEVY+E YNELVD+Y+FGMC+LEMVTF+YPYSECTHPAQIYKKV SGKKP+A Y VKDPEVR+FVEKCLA  + RL+A ELL D FLQ D  D   +RP+DY    D+ G  LR PL +                      +  YH    ESS I             VDISIKGKR  D GIFLRLRI+D E                           GRIRNIYFPF+   DTA+SVA EMV+ELDIT+QDV +IA+MID EIA LVPDW    +    +         GFC  CASN     ++     +H +       +   + C+S+HGRF ++
Sbjct:   12 SVFVEIDPSGRYGRYDEILGKGASKTVYRAFDEYEGIEVAWNQVKLRNFTRNPEELEKFFREIHLLKTLNHQNIMKFYTSWVDTNNLSINFVTELFTSGTLRQYRLRHRRVNIRAVKQWCKQILKGLLYLHSRSPPIIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAVRCVGTSKPSHHWNFIALIMFFTTLDLPLLCLCVVKGTPEFMAPEVYDEEYNELVDVYAFGMCVLEMVTFDYPYSECTHPAQIYKKVTSGKKPEAFYLVKDPEVREFVEKCLANVTCRLTALELLQDPFLQDDNMDGFVMRPIDYYNGYDETGVFLRHPLID----------------------DPLYHD-QFESSQICEIDLFANDDEDHVDISIKGKRNGDDGIFLRLRISDAEGIVSIFFDSFKIIGLKNVTRFRVLGNVGRIRNIYFPFETAIDTAWSVAVEMVSELDITNQDVAKIAEMIDAEIAALVPDWKNDTESSQNVNNNKNNNTAGFCGECASNGYIQETVSSGEKSHHNHHEFDSSE--DKSCSSVHGRFADM 542          

Query:  256 MKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGR-QIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVD-AESSGIELF-------XXXXXXXXXXVDISIKGKRREDG-GIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQ 1518
            MKFY SWVDT NRNINFVTEMFTSGTL+QYRLKHKRVNIRAVK+WCRQILRGL YLH+HDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAA L+ SHAAHCVGTPEFMAPEVY+E YN+LVDIYSFGMC+LEMVTF+YPYSEC+HPAQIYK+V+SGKKPD L KVKDPEVR F+EKCLAT SLRLSA ELL+D FL IDE   D+R V+  +  ID+ G  LR      H                 +QN+W Y+  +  ES  I+L                  VDISIKGKRR++G G+FLRL+  +KEG +RNIYFPFDIETDTA SVA EMV EL++ D+DVT+IA+MIDGEIA LVP+W                FC +  SN +S GS+M+F            +QC + GC   HGRFEE+T++
Sbjct:    1 MKFYASWVDTDNRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKNWCRQILRGLNYLHTHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAACLQHSHAAHCVGTPEFMAPEVYKEEYNQLVDIYSFGMCVLEMVTFDYPYSECSHPAQIYKRVISGKKPDGLDKVKDPEVRGFIEKCLATVSLRLSACELLDDHFLCIDE--SDMRRVESEKGLIDEAGTPLRHSYHIPHYSNGYYSLY--------NQNQWDYNGDETVESHEIDLLEFQNDDDEEEEDKRFGSVDISIKGKRRDNGDGLFLRLKTVNKEGCVRNIYFPFDIETDTAISVAREMVEELEMDDRDVTKIANMIDGEIASLVPNWSI--------------FC-SSESNRSSVGSVMDF----------NEMQCGRDGCEEKHGRFEEITFE 396          

Query:   40 FVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGK-RREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQ 1362
            +VE DP+GRYGR+ E+LGKGA KTVY+AFD+  G+EVAWNQVKL +  +SPE L+RLY E+HLLK L H++I+++ TSW+D   R  NF+TE+FTSGTL++YR K+++V+IRA+K W RQIL GL YLH HDPPVIHRDLKCDNIF+NG+ G+VKIGDLGLAAILR S  AH V GTPEFMAPE+YEE YNELVDIYSFGMC+LEM+T EYPYSECT+PAQIYKKV SGK PD+ + ++  E ++FV KCL T S RL A+ELL D FL   +               D+ PL R P                         +     + A  + +E             D+SI GK   ED  IFL+++I D +G +RNI FPF+I +DT   VA EMV EL+ITD D   IA MI+ EI+LLVP+W+     +    + ++
Sbjct:   15 YVETDPSGRYGRFREVLGKGAMKTVYKAFDQVLGMEVAWNQVKLNEVFRSPEPLQRLYSEVHLLKNLNHESIIRYCTSWIDVNRRTFNFITELFTSGTLREYRRKYQKVDIRAIKSWARQILNGLAYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQNAHSVIGTPEFMAPELYEEDYNELVDIYSFGMCVLEMLTGEYPYSECTNPAQIYKKVTSGKLPDSFHLIQHTEAQRFVGKCLETVSRRLPAKELLADPFLAATD-------------ERDLAPLFRLP------------------------QQLAIQNLAANGTVVE-HLPSTTDPTRTTDMSITGKMNSEDHTIFLQVQILDGDGHMRNIQFPFNILSDTPLEVALEMVKELEITDWDPLEIAAMIENEISLLVPNWRANDSSIRHESFGHE 419          

Query:   40 FVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGK-RREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQ 1362
            +VE DP+GRYGR+ E+LGKGA KTVY+AFD+  G+EVAWNQVKL +  +SPE L+RLY E+HLLK L H++I+++ TSW+D   R  NF+TE+FTSGTL++YR K+++V+IRA+K W RQIL GL YLH HDPPVIHRDLKCDNIF+NG+ G+VKIGDLGLAAILR S  AH V GTPEFMAPE+YEE YNELVDIYSFGMC+LEM+T EYPYSECT+PAQIYKKV SGK PD+ + ++  E ++FV KCL T S RL A+ELL D FL   +               D+ PL R P                         +     + A  + +E             D+SI GK   ED  IFL+++I D +G +RNI FPF+I +DT   VA EMV EL+ITD D   IA MI+ EI+LLVP+W+     +    + ++
Sbjct:   15 YVETDPSGRYGRFREVLGKGAMKTVYKAFDQVLGMEVAWNQVKLNEVFRSPEPLQRLYSEVHLLKNLNHESIIRYCTSWIDVNRRTFNFITELFTSGTLREYRRKYQKVDIRAIKSWARQILNGLAYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQNAHSVIGTPEFMAPELYEEDYNELVDIYSFGMCVLEMLTGEYPYSECTNPAQIYKKVTSGKLPDSFHLIQHTEAQRFVGKCLETVSRRLPAKELLADPFLAATD-------------ERDLAPLFRLP------------------------QQLAIQNLAANGTVVE-HLPSTTDPTRTTDMSITGKMNSEDHTIFLQVQILDGDGHMRNIQFPFNILSDTPLEVALEMVKELEITDWDPLEIAAMIENEISLLVPNWRANDSSIRHESFGHE 419          

Query:    4 NGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDIS---------IKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQ 1320
            + +VEP   D E +E+DPT RY RY E++GKGASKTV++ FDE +GIEVAWNQV++ D LQSP+ LERLY E+ LLK+LKHKNI++FY SW+D  N+ +N +TE+FTSG+L+QYR KH++VN++AVK W RQIL GL YLHS DPP+IHRD+KCDNIFINGN GEVKIGDLGLA ++ +++A   +GTPEFMAPE+Y+E YNEL DIYSFGMC+LEMVTFEYPY EC + AQIYKKV SG KP +L KVKDPEV +F+EKCL  AS RLSA ELL D FL ++           G  +++  PL   P   + +               +++N      +D E + + +           +++          +KG+  ++  + L LRI D+ GR+RNI+F F  E DTA +V++EMV +L++TD++V  IA++ID  +  L+P+W+
Sbjct:    8 SAIVEPP--DPEVLEIDPTCRYIRYKEVIGKGASKTVFKGFDEVDGIEVAWNQVRIDDLLQSPDCLERLYSEVRLLKSLKHKNIIRFYNSWIDDKNKTVNIITELFTSGSLRQYRKKHRKVNMKAVKCWARQILTGLKYLHSQDPPIIHRDIKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFEYPYCECRNSAQIYKKVSSGIKPASLSKVKDPEVMKFIEKCLLPASERLSAEELLLDSFLNVN-----------GLVMNNPLPL---PDIVMPKEGSFGERCLMSEGPPNARNRTMSMNLD-EDNNLPIVISSNNSGTNCIEVRRAKRGNFFVLKGEENDENSVSLILRIVDENGRVRNIHFLFFQEGDTASNVSSEMVEQLELTDKNVKFIAELIDVLLVNLIPNWK 438          

Query:   34 SEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEI-QEFRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSCE------------VMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            S FVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTA RNINFVTEMFTSGTL+QYRLKH+RVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKV+SGKKPDALYKVKDPEVRQFVEKCLAT SLRLSA+ELLND FLQID C  DLRP + G ++  +GP++R P  ELH                ++QNEW YHPV+ E +GIELF          VDISIKGK  +DGGIFLR+RIADKEGRIRNIYFPFDIETDTA +VATEMVAELDI DQDVT+IADMIDGEIA LVP+W+ GPGI ETP +ANQ  CHNCAS  TS+GS MEFLSN+P         CC  GCASMHGRF E+T+Q DESE H+TEGAPN  +Q D  H+QEIWGQ ESR+L+ IGSG+SHSD EY   DQ V  ++ +++++E N     G S ++ +GS SFS + S Y+DL+D +ENEI Q+ RWLKAK+QMELR+LRD+Q+ +  K S + + E   +N V SS +S++ Q  +N  +SKS     + +S N H N +KSC             +  SP  ED VT  +FCTG LLP SL RT SLPVDAVDV
Sbjct:    5 SGFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTAKRNINFVTEMFTSGTLRQYRLKHRRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVRQFVEKCLATVSLRLSAKELLNDPFLQIDGCGSDLRPSEPGIEVHGLGPMMRLPYLELHDNTNSYSNGYLNGYGYEAQNEWEYHPVEVEPNGIELF-EHHDEHPANVDISIKGKWGDDGGIFLRIRIADKEGRIRNIYFPFDIETDTASNVATEMVAELDINDQDVTKIADMIDGEIAALVPEWKSGPGIEETPCFANQTVCHNCASTCTSNGSFMEFLSNNP---------CCSHGCASMHGRFGEITFQVDESEDHITEGAPNIVNQPDYSHHQEIWGQQESRQLTPIGSGRSHSDEEYYNFDQPVPEKNAKEIKME-NGIPDGGKSFRHHTGSGSFSRLTSLYNDLADNNENEIQQDLRWLKAKYQMELRKLRDEQLGIAVKPSTSRNGEGITSNQVSSSSMSNSFQEDSNGDVSKSLT---KQVSHNLHGNASKSCALSDTRRHRNHKLMTRSPRPEDMVTVNNFCTGPLLPHSLHRTTSLPVDAVDV 726          

Query:    1 MNGLVE---PDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEI-QEFRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSCEVM---------VSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            MNGL     PDYS  EFVEVDPTGRYGRYNEILG+GASK VYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTL+QYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHP QIYKKV+SGKKPDALYKVKDPEVR FVEKCLAT SLRLSARELLND FLQID C+ DLR +D+  ++D +GPL+R P  E H                ++QNEW YH V+ E SGIELF          VDISIKGKR +DGGIFLRLRIADKEGRIRNIYFPFDIE DTA SVATEMVAELDITDQDVT+IADMIDGEIA LVP+W+PGPGI ETP +ANQ  CHNCAS  TS+GS M+FLSN+P         CC  GCASMHGRF E+ ++ DESEHH+TEGAPN  +Q D LHY+EIWGQ ESR+L+ IGSG+S  D EYE  DQ +  +D +D ++E+      G S ++ +GS S S + S Y+DL+D++ENEI Q+ RWLKAKHQMELR+LRD+++ L  K S + + E + +N V S+ + ++ Q  +N  L KS A   + +S + H +     +             P A+D V  K+ CTG +LP SL RT SLPVDAVDV
Sbjct:    1 MNGLSHLEPPDYS--EFVEVDPTGRYGRYNEILGRGASKIVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPVQIYKKVISGKKPDALYKVKDPEVRHFVEKCLATVSLRLSARELLNDPFLQIDGCESDLRLLDHRIEVDGLGPLMRPPYLEHHDNNNSYSSGYLNGYDYEAQNEWEYHQVEVELSGIELF-EYHDEHPANVDISIKGKRGDDGGIFLRLRIADKEGRIRNIYFPFDIENDTALSVATEMVAELDITDQDVTKIADMIDGEIASLVPEWRPGPGIEETPCFANQTLCHNCASTCTSNGSFMDFLSNNP---------CCSHGCASMHGRFGEIIFEVDESEHHLTEGAPNILNQPDYLHYKEIWGQQESRQLTPIGSGKSQLDEEYENFDQSIPEKDTKDTKMEN--GIPGGKSFQHFTGSGSLSRLTSLYNDLADSNENEIQQDLRWLKAKHQMELRKLRDERLGLAVKPSTSRNGEEKTSNVVSSTSMLNSFQEGSNGDLLKSLA---KQISHSLHTHAGALSDTQRPWNHKVMNQPPRAKDMVNAKNLCTGPMLPHSLHRTTSLPVDAVDV 730          

Query:    1 MNGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGR-QIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLS-NHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHV-TEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNST-KNLSGSHSFSVIPSTYHDLSDTHENEI-QEFRWLKAKHQMELRELRDQQIRLVSKSS----DNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNK-----------SCE-VMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            MNG    +    EFVEVDPTGRYGRYNEILGKGASKTVY+AFDEYEGIEVAWNQVKLYD LQ+ EDLERLYCEIHLLKTL H+NIMKFYTSWVDT+NRNINFVTEMFTSGTL+QYRLKH+RVNIRAVKHWCRQIL GLLYLHSHDPPVIHRDLKCDNIF+NGNQGE+KIGDLGLAAIL+KSHAA CVGTPEFMAPEVYEE YNELVDIYSFGMC+LEMVTFEYPYSEC H AQIYKKV SGKKPDALYKVKDPE+++FVEKCLAT S RLSARELLND FLQID+   DL+P+DY +  ++ +GPL+RQPL  +HR               D +NE  YH ++ E+S I+LF          V I+IKG+R ED  IFLRLRIADKEGRIRNIYF FDIETDTA SVATEM+ ELDIT+QDV ++A MID EI+ LVP+W+ G GI E+P+     FC NCAS+    G ++++ S + P A+NLQVLQC    CA++HGRFEE+TYQ +  E    T+ AP   SQS  + Y +I  Q ++   S+ GS + H D      +Q +  E+E+ + ++S   S+A  ST +N S         + Y    D +ENEI QE RWLKAK+QM+LREL+DQQ+ + SKSS    ++ + EH+  N     L+    +  NN    K  +   +N +  F  + +K           +CE + ++ + E  VT KSF TG+LLP SL R  SLPVDAVDV
Sbjct:    1 MNGPTSLEPDSYEFVEVDPTGRYGRYNEILGKGASKTVYKAFDEYEGIEVAWNQVKLYDSLQTSEDLERLYCEIHLLKTLNHENIMKFYTSWVDTSNRNINFVTEMFTSGTLRQYRLKHRRVNIRAVKHWCRQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEIKIGDLGLAAILKKSHAARCVGTPEFMAPEVYEEEYNELVDIYSFGMCVLEMVTFEYPYSECNHAAQIYKKVTSGKKPDALYKVKDPELQKFVEKCLATVSTRLSARELLNDPFLQIDDSGCDLKPIDYYQGDLNGVGPLVRQPLHGIHRSNSSLTDGYTNYMGYDLENEIEYHQLELETSPIDLFTCQEDENLENVAIAIKGRRIEDDSIFLRLRIADKEGRIRNIYFSFDIETDTAISVATEMIDELDITEQDVLKVAKMIDDEISTLVPEWKRGRGIEESPQSTYASFCQNCASH----GHLLDYFSPDSPGARNLQVLQCSIHECAAVHGRFEEITYQVEGPEQCASTDCAPVSPSQSTNITYTDITAQRDAP--STRGSKEIHCDQGLSITNQSIFEEEERIINMDSLCESNARKSTCENPS---------AVYCAHWDDYENEIRQELRWLKAKYQMQLRELKDQQLGVKSKSSSLSPNSDNMEHQKDNVPSLPLILRKAKRGNNEAALKFLS-SAKNFASCFPTDADKRWVDSGKRKVQNCEAINMACSPEPMVTAKSFYTGALLPHSLHRATSLPVDAVDV 739          

Query:    1 MNGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGR-QIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMME-FLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHV-TEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNST-KNLSGSHSFSVIPSTYHDLSDTHENEI-QEFRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSCEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            MNGL   +    EFVEVDPTGRY RYNEILGKGASKTVY+AFDEYEGIEVAWNQV+L D LQ PEDLERLYCEIHLLKTL H+NIMKFYTSWVDTANRNINFVTEMFTSGTL+QYRLKH+RVNIRAVKHWCRQIL+GLLYLHSH PPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAIL+KS+AAHCVGTPEFMAPEVY E YNELVDIYSFGMC+LEMVTF+YPYSEC H  QIYKKVVSGKKPD+LYKVKDP+VRQFVEKCLAT S RLSARELLND FL ID+C  DLRP+DY +  ++  GPL+ QPL+ +H                D +NE  YH ++ E+S I+LF          VDI+IKG+ RED  IFLRLR+ADKEG IRNIYFPFDIETDTAFSVATEM  EL ITDQDV +IADMIDGEI+ LVP+W+ G GI E+P+  +  FC NCAS+    G++ + F SN    +NL+VL C K GCA++HGRFEE+TYQ    E    T+ AP   SQS  ++  +IW Q ++   +S GS + H    +   +  +  E E+ + +++   S+A  ST +N S         ST H   D HENEI QE RWLKAK+QM+LREL+DQQ+ + SK                SSL  ++    +     K CA D  N        +NK+     SP  E  +T K+F  G+LLP SL R  SLPVDAVDV
Sbjct:    1 MNGLTSLETDYLEFVEVDPTGRYRRYNEILGKGASKTVYKAFDEYEGIEVAWNQVRLCDSLQRPEDLERLYCEIHLLKTLNHENIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRLKHRRVNIRAVKHWCRQILKGLLYLHSHYPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILKKSYAAHCVGTPEFMAPEVYGEEYNELVDIYSFGMCVLEMVTFDYPYSECNHAGQIYKKVVSGKKPDSLYKVKDPDVRQFVEKCLATVSTRLSARELLNDPFLLIDDCGFDLRPIDYYQGDLNGAGPLVTQPLYGIHCSNSSLTNGYTDYLGYDLENEIEYHQLELETSPIDLFICQEDEHLGNVDIAIKGRWREDDDIFLRLRVADKEGHIRNIYFPFDIETDTAFSVATEMFDELGITDQDVLKIADMIDGEISTLVPEWKRGMGIEESPQCTDASFCQNCASH----GNLQDYFSSNSSGTRNLEVLPCSKHGCAAVHGRFEEITYQVKGPEQSTSTDCAPVSPSQSTSINCTDIWAQRDAP--NSQGSREIHCGQGHSTTNHTIFEEQERIVNMDTLRESNARESTCENPSAF-------STTH--WDDHENEIRQELRWLKAKYQMQLRELKDQQLGVKSKP---------------SSLSPNSDNMEHQKDADKRCA-DSANKEVQNCEEINKA----FSP--EQIITAKNFYAGALLPHSLHRATSLPVDAVDV 702          

Query:   16 EPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDE----CDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDW 1317
            +PD SD+EFVE+DPTGRYGRY E+LG+GA K VYRAFDE+EGIEVAWNQVK+ D L++  DLERLY E+HLL TLKHKNI+KFY SW+DT N NINF+TE+FTSGTL+QYR KHK V +RA+K W RQIL GLLYLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAIL+++ +AH V GTPEFMAPE+YEE YNELVDIY+FGMC+LE+VT EYPY ECT+ AQIYKKV SG KP +L KVKDP V+ F+EKC A  S RL A+ELL D FLQ DE      H  RP  +                                    S ++   + +  +SS   +            D +++G+R++   IFL+LRIAD  G IRNI+FPFD+E DTA +VA+EMV ELD+TDQDV+ IA MID EI   +P W
Sbjct:   10 DPDDSDAEFVEIDPTGRYGRYKEVLGRGAFKKVYRAFDEFEGIEVAWNQVKVADLLRNSVDLERLYSEVHLLNTLKHKNIIKFYNSWIDTKNENINFITEIFTSGTLRQYRQKHKHVGLRALKKWSRQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILQQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCLLELVTVEYPYVECTNAAQIYKKVTSGIKPASLAKVKDPAVKAFIEKCTAKVSDRLPAKELLMDPFLQSDEENESVGHSFRPKAHS--------------------------------SGGSSDQIDVNEIAKDSSAEPI-----------RDFTVQGQRKDINTIFLKLRIADSTGHIRNIHFPFDVEVDTAIAVASEMVEELDLTDQDVSTIAAMIDSEIRSHIPGW 405          

Query:   16 EPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWG---YHPVDAESSGI-------ELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDW 1317
            +PD SD+EFVE+DP+GRYGRY E+LG+GA K VYRAFDE EGIEVAWNQVK+ D L++  DLERL+ E+HLLKTLKHKNI+KFY SWVDT N NINF+TE+FTSGTL++YR KHK V++RA+K W +QIL GLLYLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAIL+++ +AH V GTPEFMAPE+YEE YNELVDIY+FGMC+LE+VT EYPY EC++ AQIYKKV SG KP +L KVKDP V+ F+EKC+A  S RL A+ELL                         M P LR                       D +N  G     P    S GI       E             D S++G+R++   IFL+LRIAD  G  RNI+FPFD++ DTA +VA+EMV ELD+TDQDV+ IA MID EI   +PDW
Sbjct:   10 DPDDSDAEFVEIDPSGRYGRYKEVLGRGAFKKVYRAFDELEGIEVAWNQVKVADLLRNSVDLERLFSEVHLLKTLKHKNIIKFYNSWVDTKNENINFITEIFTSGTLRKYRQKHKHVDLRALKKWSKQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILQQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCLLELVTVEYPYVECSNAAQIYKKVTSGIKPASLAKVKDPAVKAFIEKCIAKVSDRLPAKELL-------------------------MDPFLRS----------------------DEENVSGGCSLRPKAHSSGGISDQLDVNESAKDKDSAAESSRDFSVQGQRKDINTIFLKLRIADSTGHFRNIHFPFDVKVDTAIAVASEMVEELDVTDQDVSTIAAMIDSEIRSHIPDW 407          

Query:   31 DSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGK-RREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQ 1320
            D  + E DPTGRYGR+ E+LGKGA KTVY+A DE+ GIEVAWN+VKL   L SP+DL+RLY E+HLL TL H +I+KFYTSW+D   +  NF+TEMFTSGTL++YR K+ RVNIRA+K W RQIL G++YLH HDPPVIHRDLKCDNIF+NG+ G+VKIGDLGLAAILR S +AH V GTPEFMAPE+YEE YNELVD+YSFGMC+LEM+T EYPYSECT+PAQIYKKV SGK P   +++ D E ++F+ KCL TA+ RLSA+ELL D FL  DE +                 L   P F   +                          D E   ++L            D++I GK   ED  IFL+++IA+++G +RNI+FPFDI  DT   VA EMV EL+I D +   IADMIDG I+ LVP+W+
Sbjct:   18 DHGYAETDPTGRYGRFEEVLGKGAMKTVYKAIDEFLGIEVAWNRVKLNQVLCSPDDLQRLYSEVHLLSTLNHDSIIKFYTSWIDVRRKTFNFITEMFTSGTLREYRKKYTRVNIRAIKKWARQILEGIVYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQSAHSVIGTPEFMAPELYEENYNELVDVYSFGMCVLEMLTSEYPYSECTNPAQIYKKVTSGKLPAVFHRIPDLEAQRFIGKCLVTAAKRLSAKELLLDPFLASDEAE-----------------LPHVPRFRKQKPFLN----------------------DREMEKLQL-----NDHPPRTDMTITGKLNPEDDTIFLKVQIANEDGTLRNIFFPFDILHDTPIDVAMEMVKELEIDDWEPFEIADMIDGAISALVPNWK 405          

Query:   28 SDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCV--GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQ 1320
            +D  + E DPTGRYGR  E+LG+GA KTVY+A DE+ GIEVAWNQ KL   L SPEDL+RLY E+HLL+ L H +I+KFY SW+D   +  NF+TEMFTSGTL+QYR K+ RVNIRA+K W RQIL G+ YLH HDPPVIHRDLKCDNIF+NG+ G+VKIGDLGLAAILR S +AH V   TPEFMAPE+YEE YNELVD+YSFGMC+LEM+T EYPYSECT+PAQIYKKV SGK P   Y+++D E ++F+ KCL TAS RL A+ELL D FL  DE +                 L R P     +                          D E   ++L            D+ I GK   D  IFL+++IA+++G  RNI+FPFDI  DT   VA EMV EL+I D +   IADMIDG I+ LVP+W+
Sbjct:   16 ADHGYAETDPTGRYGRLEEVLGRGAMKTVYKAIDEFLGIEVAWNQAKLSRVLCSPEDLQRLYSEVHLLRILNHDSIIKFYASWIDVRGKTFNFITEMFTSGTLRQYRQKYTRVNIRAIKKWARQILEGIEYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQSAHSVIGSTPEFMAPELYEENYNELVDVYSFGMCVLEMLTAEYPYSECTNPAQIYKKVTSGKLPAVFYRIQDLEAQRFIGKCLETASKRLPAKELLLDPFLASDEAE-----------------LSRVPRIRNQKSFLN----------------------DREMEKLQL-----NDHPPRTDMIITGKLNRDDTIFLKVQIANEDGTPRNIFFPFDILHDTPIDVAMEMVKELEIGDWEPFEIADMIDGAISDLVPNWK 404          

Query:   13 VEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQ-PL-FELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQP 1323
            +EP  + ++ VE DPTGRY RY+++LGKGA KTVYRAFDE +GIEVAWNQV++ D L+SPED E+LY E++LL++L+H+NI+KF  SWVD  N+ IN +TE+FTSG L+QYR KH+ ++I+A+K+W RQILRGL+YLH H PP+IHRDLKCDNIF+NGN GEVKIGDLGLA +++   A   +GTPEFMAPE+YEE YNELVDIYSFGMCILE+VT  YPYSEC + AQIYKKV SG KP +L  V + ++++F+EKCL  AS RLSA+ELL   FLQ++        +    QI D  P+  Q P+   L +                     G +    +S  +E             +  +KG + +D    L LRI+D  GR+RNI+F F +++DTA SVA+EMV +L++ D DV  IA++ID  I  L+P W+P
Sbjct:    1 MEPSDAGADLVEKDPTGRYVRYDDVLGKGAFKTVYRAFDEVDGIEVAWNQVRIDDVLRSPEDFEKLYSEVYLLRSLRHENIIKFSNSWVDDKNKTINMITELFTSGNLRQYRRKHRNIDIKAIKNWARQILRGLVYLHGHSPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQNPTAKSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCNYPYSECRNAAQIYKKVTSGIKPASLKTVGNTQIKEFIEKCLLPASERLSAKELLKHPFLQLE--------IPILEQICDPLPVPDQFPISLSLPKSGPLFMDMDIDEKQLSESTCTGSNNGSPKSPVLE-----YQRAHKNNEFGLKGMKNDDNSASLTLRISDLGGRVRNIHFIFYLDSDTAISVASEMVEQLELADHDVAFIAELIDSLIVKLLPGWKP 426          

Query:   40 FVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGI 1335
            F E DPTGRY R +E LGKGA KTVY+AFDE +GIEVAWNQV + D LQS + LERLY E+HLLK+LKH+NI+KFY+SWVD  N+ IN +TE+FTSG+++QYR KHK V+++A+K+W RQILRGL YLH+H PP+IHRDLKCDNIF+NGN GEVKIGDLGLA ++++  A   +GTPEFMAPE+YEE YNELVDIYSFGMC+LEMVT EYPYSEC +PAQIYKKV SG KP +L KV D +V+ F+EKCL  AS RL A ELL D FL     ++    V    Q+ ++       L                     S NE        + S +EL            +  ++G +  D  + L LRIAD  GR RNI+F F +++DTA  +A EMV +LD+  +DV  IA++ID  IA LVP W   P +
Sbjct:   14 FAEKDPTGRYIRNDEFLGKGAFKTVYKAFDEVDGIEVAWNQVNIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYSSWVDDKNKTINIITELFTSGSMRQYRKKHKTVDMKAIKNWARQILRGLHYLHTHSPPIIHRDLKCDNIFVNGNTGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVSSGIKPASLGKVSDHQVKVFIEKCLVPASTRLPAIELLKDPFL---ATENSKELVSSSLQLPNLISRQVHLLQSESHLMDIDCKKLSVGSCTKSINE------SPQFSTLELSRFTENN-----EFRLRGAKNNDNTVSLTLRIADPCGRARNIHFTFYLDSDTAVLIAEEMVEQLDLLTEDVAVIAELIDNLIAKLVPSWNTSPSV 431          

Query:    1 MNGLV--EPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWG--QHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEIQ-EFRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKS-----------CEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            MNGL+  EPDY   EFVEVDPTGRYGRYNEILGKGASK VYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKH+NIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVK+WCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMC+LEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVR+FVEKCLATASLRLSARELLND+FLQIDEC++DLR +DYGR +DDMGPL RQPL ELHR              XD+ NEW    VD ES+GIELF          VDISIKGKR EDGGIFLRLRI DKEG +RNIYFPFD E DTA SVATEMVAELDITDQD TRIA+MIDGEI++LVPDWQ GPG+ ETPR+ANQ FCHNC SNHTSSGSMME+LSNHPSAK+L  LQCCK GC SMHGRFEE+TYQADESEHHVT+G PNES QSDC+ YQEIWG  QHESRELS +GSGQ HSD EYEK+D LVTVEDEQD ++E+N AS   NS +NLSG HS  + P  YHDL D++EN IQ + RW KAKHQMELRELRD+Q+ ++S S  N SKE ++ NG LSSLVS+T+QG+NN++LSKSCAYD ++L+P+FHANL KS           CE M SPNA + +TGKS  T SLLP SLRRTVSLPVDAVD+
Sbjct:    1 MNGLLHLEPDYC--EFVEVDPTGRYGRYNEILGKGASKIVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKNWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCVLEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVREFVEKCLATASLRLSARELLNDRFLQIDECEYDLRSLDYGRHLDDMGPLARQPLLELHRSNSSFSNGYSNDYDXDAPNEW---TVDIESTGIELFEHHEDDHSDDVDISIKGKRGEDGGIFLRLRITDKEGXVRNIYFPFDTENDTALSVATEMVAELDITDQDETRIANMIDGEISMLVPDWQSGPGLEETPRFANQSFCHNCVSNHTSSGSMMEYLSNHPSAKDLLALQCCKHGCPSMHGRFEEITYQADESEHHVTKGEPNESGQSDCVQYQEIWGQQQHESRELSLVGSGQIHSDEEYEKMDXLVTVEDEQDSKVENNTASXERNSIRNLSGLHSICMSPPMYHDLPDSYENGIQKDLRWFKAKHQMELRELRDEQLGIISTSLPNASKEXKIDNGFLSSLVSNTIQGINNIVLSKSCAYDHQHLTPDFHANLEKSCPNSEPQRARNCEAMESPNAANVITGKSLYTDSLLPHSLRRTVSLPVDAVDL 745          

Query:    1 MNGLV--EPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWG--QHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEIQ-EFRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKS-----------CEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            MNGL+  EPDY   EFVEVDPTGRYGRYNEILGKGASK VYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKH+NIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVK+WCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMC+LEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVR+FVEKCLATASLRLSARELLND+FLQIDEC++DLR +DYGR +DDMGPL RQPL ELHR              XD+ NEW    VD ES+GIELF          VDISIKGKR EDGGIFLRLRI DKEG +RNIYFPFD E DTA SVATEMVAELDITDQD TRIA+MIDGEI++LVPDWQ GPG+ ETPR+ANQ FCHNC SNHTSSGSMME+LSNHPSAK+L  LQCCK GC SMHGRFEE+TYQADESEHHVT+G PNES QSDC+ YQEIWG  QHESRELS +GSGQ HSD EYEK+D LVTVEDEQD ++E+N AS   NS +NLSG HS  + P  YHDL D++EN IQ + RW KAKHQMELRELRD+Q+ ++S S  N SKE ++ NG LSSLVS+T+QG+NN++LSKSCAYD ++L+P+FHANL KS           CE M SPNA + +TGKS  T SLLP SLRRTVSLPVDAVD+
Sbjct:  337 MNGLLHLEPDYC--EFVEVDPTGRYGRYNEILGKGASKIVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKNWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCVLEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVREFVEKCLATASLRLSARELLNDRFLQIDECEYDLRSLDYGRHLDDMGPLARQPLLELHRSNSSFSNGYSNDYDXDAPNEW---TVDIESTGIELFEHHEDDHSDDVDISIKGKRGEDGGIFLRLRITDKEGXVRNIYFPFDTENDTALSVATEMVAELDITDQDETRIANMIDGEISMLVPDWQSGPGLEETPRFANQSFCHNCVSNHTSSGSMMEYLSNHPSAKDLLALQCCKHGCPSMHGRFEEITYQADESEHHVTKGEPNESGQSDCVQYQEIWGQQQHESRELSLVGSGQIHSDEEYEKMDCLVTVEDEQDSKVENNTASXERNSIRNLSGLHSICMSPPMYHDLPDSYENGIQKDLRWFKAKHQMELRELRDEQLGIISTSLPNASKEXKIDNGFLSSLVSNTIQGINNIVLSKSCAYDHQHLTPDFHANLEKSCPNSEPQRARNCEAMESPNAANVITGKSLYTDSLLPHSLRRTVSLPVDAVDL 1081          

Query:    1 MNGL--VEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQ--HESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEIQEFRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSCEVMVSPNA----------EDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            MNGL  +EPD+S  EFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEG+EVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKH NIMKFYTSWVD ANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKS AAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSEC+HP QIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATAS RLSARELLND+FLQ DEC++DLR +DY RQ+D+MGP +RQPL ELH                D+ NEWGY PVD ES+GIELF               +    ED G+           R+RNIYF FD E DTA SV+TEMVAEL +TDQDVTRIADMIDG I+LLVPDWQ GPG+VETP  ANQ FCHN  SNHTSSGSMME+LSNHPSAK+LQ +QCCK GC SMHGRFEE+TYQ DESEHHV  GAPNESSQSDC  YQEIWGQ  HESRELSS+GSGQSHSD EYEK+D LVTVEDEQD +LE+  AS A NS +NLS  HS S++                                        SKSS N SK H++ NG LSS+VS+TLQG+NN++LSKSCAYD R+++P+F ANL KSC  + S  A          E+ +T  S  TGSLLP SLRR VSLPVDAVD+
Sbjct:    1 MNGLSHLEPDFS--EFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGMEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHGNIMKFYTSWVDPANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSQAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECSHPVQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASXRLSARELLNDRFLQXDECEYDLRSLDYSRQLDNMGPFVRQPLLELHXSNSSFSNGYSNGYNFDAPNEWGYQPVDVESTGIELFEHR------------EDDHSEDVGM----------SRVRNIYFTFDTENDTALSVSTEMVAELVMTDQDVTRIADMIDGVISLLVPDWQSGPGLVETPPCANQSFCHNYVSNHTSSGSMMEYLSNHPSAKDLQAIQCCKHGCPSMHGRFEEITYQVDESEHHVKGGAPNESSQSDCPQYQEIWGQQPHESRELSSVGSGQSHSDEEYEKMDHLVTVEDEQDPQLENTTASGARNSIRNLSXLHSISIL----------------------------------------SKSSLNASKVHKIDNGFLSSVVSNTLQGINNIVLSKSCAYDHRHITPDFLANLEKSCPNLESQRARNCXAMESPKENVITANSLYTGSLLPHSLRRAVSLPVDAVDL 684          

Query:    1 MNGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVS-------GKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLS-NHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQS---HSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEI-QEFRWLKAKHQMELRELRDQQIRLVSKSS----DNGSKEHELANGVLSSLVS------STLQGLNNVMLSKSCAY-----DQRNLSPNFHANLNKSCEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            MNG    +   SEFVEVDPTGRYGRYNE+LGKGASKTVYRAFDEYEGIEVAWNQVKLYDFL++PEDLERLY EIHLLKTLKH NIMKFYTSWVDT NRNINFVTEMFTSGTL+QYRLKHKRVNIRAVKHWCRQIL+GLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAA+LRKSHA  CVGTPEFMAPEVYEE YNELVDIYSFGMCILEMVTFEYPYSEC +PAQIYKKV++       GKKP+AL+KVKDPEVR+FVEKCL T S RLSARELL D FLQ+D+  ++LRP +  R + ++GPLLRQP   LH+               +++N+  Y+P+D   S I+LF          VD++IKG+RRED  IFLRLRIADKEGRIRNIYFPFD E DTA SVA EMV+ELDITDQDVT+IA+MIDGEI  LVP+W  G GI E P   N  FC NCA    S GS++++ S + P  K+LQVLQC K G A++HGRFEE+TYQ + +E  +T GAP  S+ SD LHY +IW Q E  ELSS GSG S     +  +E LD     ++E+ + +++   S A NS      + S         D  D +ENE+ QE RWLKA +QM+LRE+RDQQ+    K+S    ++   E+   NG   SL S      +    L +    K   Y     ++++L+     N +++ +   SP  E  +T KSF  G+LLP SL R  SLPVDA+DV
Sbjct:    1 MNGGTASEEEFSEFVEVDPTGRYGRYNEVLGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLRNPEDLERLYREIHLLKTLKHNNIMKFYTSWVDTTNRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCRQILKGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAVLRKSHADRCVGTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECNNPAQIYKKVITVGTLNSQGKKPEALFKVKDPEVRRFVEKCLVTVSXRLSARELLRDPFLQVDDYGYNLRPTEDQRDMYEIGPLLRQPHSSLHQSNSSLSNGHGNYLGYETENDLDYNPIDYGLSEIDLFACQEDEHFGDVDLTIKGRRREDDDIFLRLRIADKEGRIRNIYFPFDTENDTALSVAREMVSELDITDQDVTKIAEMIDGEITTLVPEWIKGRGIEEIPHCNNASFCQNCA----SYGSILDYASPDIPGVKHLQVLQCSKHGSAAVHGRFEEITYQVEGAERSLT-GAPRTSNHSDGLHYADIWAQREGPELSSQGSGDSSDIQCNENHETLDVTNFGKEERIIMMDNQSDSKARNSISEKLSATS---------DRLDDYENELRQELRWLKATYQMQLREIRDQQLGARPKASSLIPNSNHSENRETNGASMSLASPQRTKENKKPSLKSFSSGKHFTYFPVDAEKKHLASPGVQN-HEAFDGAYSP--EQIITAKSFYIGALLPHSLHRATSLPVDAIDV 744          

Query:    1 MNGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVS-------GKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNH-PSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHS---DGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEI-QEFRWLKAKHQMELRELRDQQI----RLVSKSSDNGSKEHELANGVLSSLVS------STLQGLNNVMLSKSCAY-----DQRNLSPNFHANLNKSCEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            MN +   +   SEFVEVDPTGRYGRYNE+LGKGASKTVYRAFDEYEGIEVAWNQVKLYDF ++PEDLERLYCEIHLLKTLKH NIMKFY+SWVDTANRNINFVTE+F       YRLKHKRVNIRAVKHWC+QIL+GLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAA+LRKSHA  CVGTPEFMAPEVYEE YNELVDIYS GMCILEMVTFEYPYSECTHPAQIYKKV++       GKKP+AL+KVKDPEV +FVEKCL T S RLSARELL D FLQ+DE  +DLRP++Y   +  +GPLLRQP   LH+               +++N+  Y+PVD   S I+L           VD++IKG+RRED GIFLRLRIAD EGRIRNIYFPFD E DTA SVA EMV+ELDIT QDVT+IA+MIDGEIA LVP+W  G G+ E P   N  FC NCA    S GS++++ S+  P   +LQVLQC K   A++HGRFEE+TYQ + SE  +TEGAP  S+ SD LHY +IW Q E  ELSS GSG S     D  +E LD     ++E+ + +++  +S   N         S S   S  +D  D +ENE+ QE RWLKA +QM+LRE+RDQQ+    +  S S ++   EH   NG   SL S      +    L     +K   Y     ++++L+ N  A  +++ +   SP  E  VT KSF   +LLP SL R  SLPVDA+DV
Sbjct:    1 MNSVTASEEDFSEFVEVDPTGRYGRYNEVLGKGASKTVYRAFDEYEGIEVAWNQVKLYDFQRNPEDLERLYCEIHLLKTLKHSNIMKFYSSWVDTANRNINFVTEIFF-----WYRLKHKRVNIRAVKHWCKQILKGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAVLRKSHADRCVGTPEFMAPEVYEEEYNELVDIYSLGMCILEMVTFEYPYSECTHPAQIYKKVITVGTQNSQGKKPEALFKVKDPEVXRFVEKCLVTVSRRLSARELLRDPFLQVDEYGYDLRPIEYQGDMYVIGPLLRQPHSALHQSNSSFSNGYGNYLGYETENDLDYNPVDYRLSEIDLLACQEDEHLGDVDLTIKGRRREDDGIFLRLRIADNEGRIRNIYFPFDTENDTAXSVAREMVSELDITYQDVTKIAEMIDGEIASLVPEWIXGRGMEEIPHCXNASFCQNCA----SYGSILDYASSDIPGVNHLQVLQCSKHASAAVHGRFEEITYQVEGSEQSLTEGAPRTSNHSDGLHYADIWAQREGPELSSQGSGDSRDIQCDENHETLDATNFGKEERIIAMDNQSSSKXRN---------SISEKLSATNDPLDDYENELRQELRWLKATYQMQLREIRDQQLGXKPKASSLSPNSDHSEHRETNGASMSLASPQRTKENKKPSLKPFCSAKHFTYFPVDAEKKHLA-NPGAQNHEAFDGAYSP--EQIVTAKSFYASALLPHSLHRATSLPVDAIDV 740          

Query:    1 MNGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNH-PSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHS---DGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEI-QEFRWLKAKHQMELRELRDQQI----RLVSKSSDNGSKEHELANGVLSSLVS------STLQGLNNVMLSKSCAY-----DQRNLSPNFHANLNKSCEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            MN +   +   SEFVEVDPTGRYGRY                   EGIEVAWNQVKLYDF ++PEDLERLY EIHLLKTLKH NIMKFY+SWVDTANRNINFVTEMFTSGTL+QYRLKHKRVNIRAVKHWC+QIL+GLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAA+LRKSHA  CVGTPEFMAPEVYEE YNELVDIYS GMCILEMVTFEYPYSECTHPAQIYKKV++GKKP+AL+KVKDPEV +FVEKCL T S RLSARELL D FLQ+DE  +DLRP++Y   +  +GPLLRQP   LH+               +++N+  Y+PVD   S I+L           VD++IKG+RRED GIFLRLRIAD EGRIRNIYFPFD E DTA SVA EMV+ELDIT QDVT+IA+MIDGEIA LVP+W  G G+ E P   N  FC NCA    S GS++++ S+  P   +LQVLQC K   A++HGRFEE+TYQ + SE  +TEGAP  S+ SD LHY +IW Q E  ELSS GSG S     D  +E LD     ++E+ + +++  +S   N         S S   S  +D  D +ENE+ QE RWLKA +QM+LRE+RDQQ+    +  S S ++   EH   NG   SL S      +    L     +K   Y     ++++L+ N  A  +++ +   SP  E  VT KSF   +LLP SL R  SLPVDA+DV
Sbjct:    1 MNSVTASEEDFSEFVEVDPTGRYGRY-------------------EGIEVAWNQVKLYDFQRNPEDLERLYXEIHLLKTLKHSNIMKFYSSWVDTANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCKQILKGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAVLRKSHADRCVGTPEFMAPEVYEEEYNELVDIYSLGMCILEMVTFEYPYSECTHPAQIYKKVITGKKPEALFKVKDPEVXRFVEKCLVTVSRRLSARELLRDPFLQVDEYGYDLRPIEYQGDMYVIGPLLRQPHSALHQSNSSFSNGYGNYLGYETENDLDYNPVDYRLSEIDLLACQEDEHLGDVDLTIKGRRREDDGIFLRLRIADNEGRIRNIYFPFDTENDTAXSVAREMVSELDITYQDVTKIAEMIDGEIASLVPEWIXGRGMEEIPHCXNASFCQNCA----SYGSILDYASSDIPGVNHLQVLQCSKHASAAVHGRFEEITYQVEGSEQSLTEGAPRTSNHSDGLHYADIWAQREGPELSSQGSGDSRDIQCDENHETLDATNFGKEERIIAMDNQSSSKXRN---------SISEKLSATNDPLDDYENELRQELRWLKATYQMQLREIRDQQLGXKPKASSLSPNSDHSEHRETNGASMSLASPQRTKENKKPSLKPFCSAKHFTYFPVDAEKKHLA-NPGAQNHEAFDGAYSP--EQIVTAKSFYASALLPHSLHRATSLPVDAIDV 719          

Query:   16 EPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDE----CDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPG 1326
            + D +D+EFVEVDPTGRYGRY E+LGKGA K VYRAFDE EG+EVAWNQVK+ D L++ EDL RLY E+HLLKTLKHKNI+KFY SWVD  + NIN +TE+FTSGTL+QYR KHK V++RA+K W RQIL GL YLH+HDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILR++ +AH V GTPEF APE+YEE YNELVDIY+FGMC+LE+VTFEYPY EC++ AQI+KKV SG KP +L KV DP V+ F+EKC+   S RL A+ELL D FLQ D+        LRP  Y                                    S  E      D E+   +             D S++G+R++D  IFL+LRIAD  G  RNI+FPFDI  DTA +VA+EMV ELD+TDQDV+ +A++ID EI   +PDW  G
Sbjct:   10 DTDDADTEFVEVDPTGRYGRYKEVLGKGAFKKVYRAFDELEGLEVAWNQVKVADLLRNSEDLVRLYSEVHLLKTLKHKNIIKFYNSWVDAKHENINIITEIFTSGTLRQYRRKHKHVDLRALKKWSRQILEGLWYLHNHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQARSAHSVIGTPEFXAPELYEEEYNELVDIYAFGMCLLELVTFEYPYVECSNAAQIFKKVTSGVKPASLXKVTDPGVKAFIEKCIVKVSERLPAKELLMDPFLQSDDNRESISRSLRPTHY------------------------------------SDAEGSSDQTDIETKDTD------PSHETSRDFSVQGQRKDD-TIFLKLRIADSTGHFRNIHFPFDIGEDTAIAVASEMVQELDLTDQDVSTLAEIIDSEIHSHIPDWPHG 408          

Query:   16 EPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDE----CDHDLRPVDYGRQIDDMGPLLRQPL-FELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVE-TPRYANQGFCHNCASNHTSSGSMME-FLSNHPSAKNLQV-----LQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHS-DGEYEKLDQLVTVEDEQ-----DLELES-NPASHAGNSTKNLSGSHSF-----SVIPSTYHDLSDTHENEIQEFRWLKAKHQMELREL 1887
            + D +D EFVEVDPTGRYGR          +  YRAFDE EGIEVAWNQVK+ D L++ EDLERLY E+HLLKTLKHKNI+KFY SWVD  + NIN +TE+FTSGTL+QYR KHK V++RA+K W RQIL GL YLH+HDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILR++ +AH V GTPEFMAPE+YEE YNELVDIY+FGMC+LE+VTFEYPY EC++ AQI+KKV SG KP +L KV DP V+ F+EKC+   S RL A+ELL D FLQ D+        LRP  Y  ++  +    R  + F  H                    E     +D E+  ++             D S++G+R++D  IFL+LRIAD  G  RNI+FPFDI  DTA +VA+EMV ELD+TDQDV+ IA++ID EI   +PDW  G    +     A+  + H    N  +S  + E  LS++ + + L        +  K+G  +  G++  V    +     VT G   E+  S         G     E    G+G S+S +G  E+ ++      E+     D   ES +  SHA  +   ++G H F      +I     +L    + E+ E   LK KH++ + +L
Sbjct:  393 DTDDADIEFVEVDPTGRYGR----------ELRYRAFDELEGIEVAWNQVKVADLLRNSEDLERLYSEVHLLKTLKHKNIIKFYNSWVDAKHENINLITEIFTSGTLRQYRRKHKHVDLRALKKWSRQILEGLWYLHNHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLELVTFEYPYVECSNAAQIFKKVTSGVKPASLAKVTDPGVKAFIEKCIVKVSERLPAKELLMDPFLQSDDDRESITRSLRPTHYSGKVSFLSSAQRLFVSFSSHCDML--------------DAEGSSDQIDIETKDMD------PSHETNRDFSVQGQRKDD-TIFLKLRIADSTGHFRNIHFPFDIGEDTAIAVASEMVQELDLTDQDVSTIAELIDSEIHSHIPDWPIGENSGDHIDGEASTPYSHASEYNEDASPLIHEDLLSSNLALERLPSGRKYWCESPKEGGGNSPGKY--VITNLNSPADPVTAGGAEENENSP--------GSSPREEDDENGAGPSNSPNGGVEEDEKSPGGHREENNPNGDGASESPSGDSHAATNPHLINGVHPFESEEVKIIAEKLENLLVEQKKELDE---LKRKHELAIADL 997          

Query:   40 FVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGK-RREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQP 1323
            +VE+DPT RYGR+ E+LGKGA KTVY+A DE  G+EVAWNQVKL   L+SPEDL+RLY E+HLL TL H +I++FYTSW+D  +R  NF+TEMFTSGTL++YR K+ +V+IRA+K+W RQILRGL+YLH HDPPVIHRDLKCDNIF NG+ G+VKIGDLGLAAILR S +AH V GTPEFMAPE+Y+E YNELVD+YSFGMC+LEM+T EYPYSEC + AQIYKKV +GK P A Y+++D E ++FV KCL  AS RLSA+ELL D FL                   D G     PL +L R                          D E   ++L            D++I GK   ED  IFL+++IADK+G +RNIYFPFD+  DT F VATEMV EL+ITD +   IA+MI+GEI+ LVPDW+P
Sbjct:    9 YVEMDPTARYGRFEEVLGKGAMKTVYKAIDELLGMEVAWNQVKLNQVLRSPEDLQRLYSEVHLLSTLNHDSIIRFYTSWIDIEHRTFNFITEMFTSGTLREYRKKYNQVDIRAIKNWARQILRGLVYLHGHDPPVIHRDLKCDNIFXNGHLGQVKIGDLGLAAILRGSQSAHSVIGTPEFMAPELYDEDYNELVDVYSFGMCVLEMLTSEYPYSECVNAAQIYKKVTAGKLPGAFYRIEDLEAQRFVGKCLVNASKRLSAKELLLDPFL-------------------DCGKDESLPLGKLGRPKPFLN--------------------DKEMEKLQL-----SDHPTRTDMTITGKLNSEDDTIFLKVQIADKDGSLRNIYFPFDVLNDTPFDVATEMVKELEITDWEPFEIANMIEGEISALVPDWKP 394          

Query:   40 FVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRP-VDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRR-EDGGIFLRLRIADKEGR-IRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVP---------DWQP--------------GPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPS 1437
            +VE DP+GRYGR+ E+LGKGA KTVY+AFDE  G+EVAWNQVKL D   SP++L+RLY E+HLLK L H +I+++Y SW+D   R  NF+TEMFTSGTL++YR K+++VNI AVK+W RQILRGL YLH  DPPVIHRDLKCDNIF+NG+ G+VKIGDLGLAAILR +  AH V GTPEFMAPE+Y+E YNELVDIY+FGMC+LEM+T EYPYSEC++PAQIYKKV SGK P+A Y ++D E ++FV KCL   S RL A ELL D FL  D+ +    P + + + I D  P+                                   V+AE    EL            ++ I GK   ED  I L++RI+D +G+ +RNIYFPFDI  DTA  VATEMV EL+I D +   IA MI+ EI+ L+          D+ P                GI   P YA      +C+S+  S  ++     NH S
Sbjct:   23 YVETDPSGRYGRFREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLNDVFXSPDELQRLYSEVHLLKNLNHDSIIQYYASWIDVNRRTFNFITEMFTSGTLREYRQKYQQVNIGAVKNWSRQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGTQHAHSVIGTPEFMAPELYDEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYNIEDLEAQRFVGKCLENVSKRLPAHELLLDPFLASDDGELASSPRIPFLKLIPDNDPV-----------------------------------VEAEDEEDELHFAAEVDLERSTNMIITGKMNLEDDTITLKVRISDLDGKNVRNIYFPFDILNDTAIEVATEMVKELEINDWEPPEIAGMIENEISSLIAGSKKWGSPRDYHPHQHSFNYEEEDDNNNGGITHHPFYA----FSSCSSSQNSLHALSFHCKNHDS 476          

Query:    1 MNGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELF-XXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEIQ-EFRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSCEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            MNG+   +  +SEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEY+GIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKH+NIMKFYTSWVDTANRNINFVTEMFTSGTL+QYRLKHKRVNIRAVKHWCRQIL GLLYLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKV+SGKKPDALY+VKDPEVRQFVEKCLAT SLRLSARELL+D FLQID+ ++DLR VD G ++D+ GPL+RQP F+LHR                 + +WG HP + E SGIELF           VDISIKGKR++DGGIFLRLRIADKEGRIRNIYFPFDIE DTA SVATEMVAELD+TDQDVTRIADMIDGEIA LVP+W+PGPGI ETPR+ANQG CHNC SNHTSSGS ++FLSN+P  KNLQ+L CC+ GCASMHGRF E+T+Q+++                  L YQE+W QHESRELS + S QSHSD +YE+LD+ +  +D+     E   + +A NS +NLSGSH FS I STY DL D +E EIQ E RWL+AK+QMELR+ +D+Q    S S ++   EH   NG LS  ++ TL+G NN   S    ++    SPN      ++C  + SP  E  VT KSF TGSLLP SL RTVSLPVDAVD+
Sbjct:    1 MNGVTHLEPDESEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYQGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCRQILSGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYRVKDPEVRQFVEKCLATVSLRLSARELLDDPFLQIDDYEYDLRTVDNG-ELDEFGPLMRQPFFDLHRSYSNFSNEYTNGFGY--EGDWGPHPAEIEPSGIELFEYRDDDEPSEDVDISIKGKRKDDGGIFLRLRIADKEGRIRNIYFPFDIEMDTAISVATEMVAELDMTDQDVTRIADMIDGEIASLVPEWRPGPGIDETPRFANQGLCHNCVSNHTSSGSFLDFLSNNPDNKNLQLLDCCRHGCASMHGRFGEITFQSED------------------LQYQELWNQHESRELSPVESDQSHSDEQYEQLDKPILAKDKAQDVWEDKFSPNAANSLRNLSGSHDFSTIRSTYCDLEDDYEKEIQKELRWLRAKYQMELRDHKDRQFGQCSHSCNS---EHRTENGFLSPSLTETLKGGNNGTHSHPHVHES---SPNSDTQRAQNCVAIKSP-GEGMVTAKSFYTGSLLPHSLHRTVSLPVDAVDI 708          

Query:   13 VEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQ-ADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEI-QEFRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSC 2082
            +EPDYS  EFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTL+QYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVD+YSFGMCILEMVTFEYPYSECTHPAQIYKKV+SG+KPDALYKVKDPEVRQFVEKCLAT SLRLSARELLND FLQ+D+C+ +++ +DYG + D MGPL+RQP +E H                ++QNE+ Y+PV+ E SGIELF          +DISIKGKRR+DGGIFLRLRIADK+GRIRNIYFPFDIETDTA +VATEMVAELDITDQDVT+IA+MID EIA LVP+W+ GPGI ETPR+AN   CHNCAS  TS+GS+M+F+SN+P         CC+ GCASMHGRFEE+T+Q ADESEHH+TE APN  S SDC+ YQ IW QHESRE++ +GSG+SHSD EYEK DQ ++ +DE D+++E+   S + NS   L GS SF  +PS   DL D++EN++ QE RWLKAK+Q+EL +LRDQQ+   S+SS + + + ++ NGV SS + ++ Q   N  L KS A+ ++   PN H ++NKSC
Sbjct:    8 LEPDYS--EFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDVYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGRKPDALYKVKDPEVRQFVEKCLATVSLRLSARELLNDPFLQMDDCESNIKSIDYGEEFDGMGPLIRQPYYEFHDDTYPYSNGYSNGYGYEAQNEFEYYPVEFEQSGIELFEHHDDEHSPNLDISIKGKRRDDGGIFLRLRIADKDGRIRNIYFPFDIETDTALTVATEMVAELDITDQDVTKIAEMIDEEIASLVPEWRRGPGIEETPRFANLTLCHNCASARTSNGSLMDFISNNP---------CCRNGCASMHGRFEEITFQAADESEHHLTEVAPNALSHSDCVDYQRIWAQHESREVTPMGSGRSHSDEEYEKFDQSISTKDENDVKMENGSQSGSRNSIPYLKGSGSFYRLPSVCSDLQDSNENKMQQELRWLKAKYQIELSKLRDQQLDFASRSSTSINTDCKIRNGVSSSTIMNSFQENRNEDLLKSFAH-EKLYRPNLHTDVNKSC 687          

Query: 2117 SLARVSAQGHCFLSLFAGQFLSQLMQLM 2200
            SL R+SA  HC  + F GQ   QLM L+
Sbjct:  718 SLPRISALVHCCHTRFTGQHPFQLMLLI 745          

Query:    1 MNGLVE---PDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEI-QEFRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSCEVM---------VSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            MNGL     PDYS  EFVEVDPTGRYGRYNEILG+GASK VYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTL+QYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHP QIYKKV+SGKKPDALYKVKDPEVR FVEKCLAT SLRLSARELLND FLQID C+ DLR +D+  ++D +GPL+R P  E H                ++QNEW YH V+ E SGIELF          VDISIKGKR +DGGIFLRLRIADKEGRIRNIYFPFDIE DTA SVATEMVAELDITDQDVT+IADMIDGEIA LVP+W+PGPGI ETP +ANQ  CHNCAS  TS+GS M+FLSN+P         CC  GCASMHGRF E+ ++ DESEHH+TEGAPN  +Q D LHY+EIWGQ ESR+L+ IGSG+S  D EYE  DQ +  +D +D ++E+      G S ++ +GS S S + S Y+DL+D++ENEI Q+ RWLKAKHQMELR+LRD+++ L  K S + + E + +N V S+ + ++ Q  +N  L KS A   + +S + H +     +             P A+D V  K+ CTG +LP SL RT SLPVDAVDV
Sbjct:    1 MNGLSHLEPPDYS--EFVEVDPTGRYGRYNEILGRGASKIVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPVQIYKKVISGKKPDALYKVKDPEVRHFVEKCLATVSLRLSARELLNDPFLQIDGCESDLRLLDHRIEVDGLGPLMRPPYLEHHDNNNSYSSGYLNGYDYEAQNEWEYHQVEVELSGIELF-EYHDEHPANVDISIKGKRGDDGGIFLRLRIADKEGRIRNIYFPFDIENDTALSVATEMVAELDITDQDVTKIADMIDGEIASLVPEWRPGPGIEETPCFANQTLCHNCASTCTSNGSFMDFLSNNP---------CCSHGCASMHGRFGEIIFEVDESEHHLTEGAPNILNQPDYLHYKEIWGQQESRQLTPIGSGKSQLDEEYENFDQSIPEKDTKDTKMEN--GIPGGKSFQHFTGSGSLSRLTSLYNDLADSNENEIQQDLRWLKAKHQMELRKLRDERLGLAVKPSTSRNGEEKTSNVVSSTSMLNSFQEGSNGDLLKSLA---KQISHSLHTHAGALSDTQRPWNHKVMNQPPRAKDMVNAKNLCTGPMLPHSLHRTTSLPVDAVDV 730          

Query:    1 MNGLVEPDYSD-SEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEIQE-FRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQ----------RNLSPNFHANLNKSCEV-MVSPNAED---EVTGKSFCT-GSLLPQSLRRTVSLPVDAVDV 2202
            MNG++ P+  D SEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKT+KH NIMKFYTSWVDTANRNINFVTEMFTSGTL+QYR KHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEE YNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKV+SGKKPDALYKVKDPEVR+FVEKCLA+ SLRLSARELL D FL+ID+C+ DLRP++  R+ DDM PLLRQP  E H                D+ N WGY P++ E +GIELF          VDISIKGKRRED GIFLRLRIADKE  IRNIYFPFDIE DTA SVATEMVAELDITDQDVT+IADMIDGEIA LVP+W+PGPGI ETP +A    CHNC SNHTS+GS+M+ L+N+P AKNLQ+ Q C  GCA+MHGRFEE+TYQ D ++HH+ EG      QS+ LH  EIW +HESRELSS+ SG+S SD EYEK++  + ++DE+     +  AS+  NS  +L    S S IPS    LSD +ENEIQ+  RWLKAKHQME+R LRD Q+   SK S   +++ +  N  L S +S+T QG NN +  KS AYD+             SP+   +  ++CE    S +AED    VT KSF T GSLLP  + RT+SLPVDAVD+
Sbjct:    1 MNGVINPEADDYSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTMKHNNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRQKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVREFVEKCLASVSLRLSARELLQDPFLRIDDCESDLRPIECRREPDDMVPLLRQPFLEYHHSNNSFSNGYSNAVDFDAHNGWGYQPLEMEPTGIELFEYHEDEHPANVDISIKGKRREDDGIFLRLRIADKEDHIRNIYFPFDIEMDTALSVATEMVAELDITDQDVTKIADMIDGEIASLVPEWKPGPGIEETPCFATLNLCHNCVSNHTSNGSLMDILANNPGAKNLQIFQ-CSNGCAAMHGRFEEITYQVDGADHHIPEG------QSEELHCTEIWDKHESRELSSVSSGESPSDEEYEKINHSI-IKDERGSGTGNVVASNVKNSISHLRNPSSSSAIPSMSCALSDDYENEIQQVLRWLKAKHQMEMRGLRDLQLGFASKPSSLDNRQLKPDNEGLFSTLSNTSQGHNNGLFLKSSAYDKHFTSNCATQVNKCSPDLVTHGARNCEANKGSRSAEDMVHVVTAKSFYTAGSLLPCPIHRTMSLPVDAVDI 743          

Query:    1 MNGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELF-XXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEIQ-EFRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSCEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            MNG+   +  +SEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEY+GIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKH+NIMKFYTSWVDTANRNINFVTEMFTSGTL+QYRLKHKRVNIRAVKHWCRQIL GLLYLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKV+SGKKPDALY+VKDPEVRQFVEKCL T SLRLSARELLND FLQID+ ++DL+ V+ G ++D+ G L+RQP F+LHR                 + +WG HP + E SGIELF           VDISIKGKR++DGGIFLRLRIADKEGRIRNIYFPFDIE DTA SVATEMVAELD+TDQDVTRIADMIDGEIA LVP+W+PGPGI ETPRYAN+GFCHNC SNHTSSGS ++FLSN+P  KNLQ+L+CC+ GCASMHGRF E+T+Q+++                  L YQE+W QHESRELS + S QSHSD + E+LD+ +  +D+     E   + +A NS +NLSGSH FS I STY DL D +E EIQ E RWL+AK+QMELR+ +D Q    S SS++   EH   NG LS  ++ TL+G NN   S    ++    SPN      ++CE + SP             GSLLP SL RTVSLPVDAVD+
Sbjct:    1 MNGVTHLEPDESEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYQGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCRQILSGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYRVKDPEVRQFVEKCLVTVSLRLSARELLNDPFLQIDDYEYDLKTVENG-ELDEFGSLMRQPFFDLHRSYSNFSNEYSNGFGY--EGDWGPHPAEIEPSGIELFEYHDDDEPSEDVDISIKGKRKDDGGIFLRLRIADKEGRIRNIYFPFDIELDTAISVATEMVAELDMTDQDVTRIADMIDGEIASLVPEWRPGPGIDETPRYANEGFCHNCVSNHTSSGSFLDFLSNNPGNKNLQLLECCRHGCASMHGRFGEITFQSED------------------LQYQELWNQHESRELSPVESDQSHSDEQCEQLDKPIPAKDKAQDVWEKKFSPNAANSLRNLSGSHDFSTIRSTYCDLEDDYEKEIQKELRWLRAKYQMELRDHKDGQFGQCSHSSNS---EHRTENGFLSPSLTETLKGGNNGTRSHPHVHES---SPNSDTQRAQNCEAIESPG-----------EGSLLPHSLHRTVSLPVDAVDI 698          

Query:    1 MNGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEI-QEFRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSC-------------EVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            M+G+ + +   SEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKH+NIMKFYTSWVD ANRNINFVTEMFTSGTL+QYRLKHKRVNIRAVKHWCRQILRGL YLHSH+PPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHA HCVGTPEFMAPEVY EAYNELVDIYSFGMCILEM+TFEYPYSECTHPAQIYKKV+SGKKPDALYKVKDPEVRQF++KCLAT S RLSA ELLND FL++D  ++DLRPVDYGR +DD+ PL+RQP  ELHR               ++ +E GYHP+D E++GIELF          VDISIKGK  EDGGIFLRLRIADKEGRIRNIYFPFD+ETDTA SVATEMVAELD+TDQDVTRIADMIDGEIA LVP+W+PGPGI ETPR+ANQ +CHNCA +  +S S    L N    KN +V QCC    ASMHGRFEE+ YQADES HH  E APN SS    L+Y EIWG HESRELSS+ S QSHSD +YEK D+ +T  D +++ +ES  A +   + ++L  S SFS  PS      D +EN++ QE RW+KAK+Q+EL +LRDQQ+ L SKSS +  K+ ++ N         T +G +N +L  S + D    S + H  +N SC             + + S   E   T K+ C GSLLP SL RT+SLPVDAV +
Sbjct:    1 MDGVSDLELDCSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDIANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCRQILRGLHYLHSHEPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHADHCVGTPEFMAPEVYAEAYNELVDIYSFGMCILEMITFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVRQFIDKCLATVSYRLSAAELLNDPFLRVDNGEYDLRPVDYGRGLDDVCPLIRQPYLELHRSDSSFCTGYPYDYSFEASSESGYHPIDNETNGIELFEYCEGEHSEDVDISIKGKMSEDGGIFLRLRIADKEGRIRNIYFPFDVETDTALSVATEMVAELDMTDQDVTRIADMIDGEIASLVPEWRPGPGIEETPRFANQSYCHNCAPSTYNSASNGLMLRNR-DGKNSEVAQCCGHRYASMHGRFEEIMYQADESGHHTAEEAPNVSSHPGGLNYPEIWGHHESRELSSMSSRQSHSDEDYEKTDRPLTDTDTKEMIMESKTAPNTRRTLRSLMNSLSFSETPSP----PDINENDVQQEMRWIKAKYQLELNKLRDQQLNLSSKSSSSEDKQQKMEN--------ETPRGNHNQILDSS-SRDTNRSSTDSHVYINNSCYSTDVPKQRARNRKAVESSIVEKVATAKNACNGSLLPSSLHRTISLPVDAVHI 734          

Query:    1 MNGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELF-XXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGS-GQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDL-SDTHENEIQ-EFRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNV-------------MLSKSCAYDQRNLSPNFHANLNKSCEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            MNG+   +  DSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEY+GIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTL+QYRLKHKRVNIRAVKHWC QILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEE+YNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKV+SGKKPDALYKVKDPEVRQFV+KCLAT SLRLSA+ELL+D FLQID+ ++DLRPVD G ++ D GPL+RQPL++LHR                 + +  YHPVD E  GIELF           VDISIKGK+++DG IFLRLRI+DKEGR+RNIYFPFDIE DTA SVATEMVAELDITDQDVT IADMIDGEIA LVP+WQ GPGIVETPR+ANQGFC NC SNHTSSGS+M+FLS++    +LQ+ +CCK GCAS HGRFEE+T+Q++E ++HV E   N ++ +D L Y  +W QHESRELS + S  QSHSD + E+LD+ ++ E +     ES    +A  S +  SG+  FS I S Y  L  D +E EIQ E RWLKA++ MELR L+DQQ+ +  KSS  G+ EH++   ++   ++ T +G ++V             + S+ C +     SP+  A + ++CE M SP     VT KSF +GSL P SL RTVSLPVDAVD+
Sbjct:    1 MNGVTHLEEDDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYQGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCIQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEESYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVRQFVDKCLATVSLRLSAKELLDDPFLQIDDYEYDLRPVDSG-ELGDFGPLIRQPLYDLHRSYSNFSNEYSNGFGY--EGDCYYHPVDNEPCGIELFEHHDDEEPSEHVDISIKGKKKDDGSIFLRLRISDKEGRVRNIYFPFDIEMDTAISVATEMVAELDITDQDVTSIADMIDGEIASLVPEWQSGPGIVETPRFANQGFCRNCVSNHTSSGSLMDFLSHNQG--SLQLPECCKHGCASTHGRFEEITFQSEEYDNHVRENM-NIANIADGLQYLGLWNQHESRELSPVESDDQSHSDEQNEQLDKSISAEGQGHNICESKFPPNAIISPRYSSGTRDFSNIRSLYCGLDGDGYEKEIQKELRWLKARYLMELRGLKDQQLGITDKSSRGGNGEHKIDYAIMLPSLTETFKGADSVIRLQSVINNWSSDLSSRPCVHKS---SPDSDAKMAENCEAMGSPGEGMMVTAKSFYSGSLFPHSLHRTVSLPVDAVDI 742          

Query:  106 KTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEIQE-FRWLKAKHQMELRELRDQQIRLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQ----------RNLSPNFHANLNKSCEV-MVSPNAED---EVTGKSFCT-GSLLPQSLRRTVSLPVDAVDV 2202
            K  YRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKT+KH NIMKFYTSWVDTANRNINFVTEMFTSGTL+QYR KHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEE YNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKV+SGKKPDALYKVKDPEVR+FVEKCLA+ SLRLSARELL D FL+ID+C+ DLRP++  R+ DDM PLLRQP  E H                D+ N WGY P++ E +GIELF          VDISIKGKRRED GIFLRLRIADKE  IRNIYFPFDIE DTA SVATEMVAELDITDQDVT+IADMIDGEIA LVP+W+PGPGI ETP +A    CHNC SNHTS+GS+M+ L+N+P AKNLQ+ Q C  GCA+MHGRFEE+TYQ D ++HH+ EG      QS+ LH  EIW +HESRELSS+ SG+S SD EYEK++  + ++DE+      N AS+  NS  +L    S S IPS    LSD +ENEIQ+  RWLKAKHQME+R LRD Q+   SK S   +++ +  N  L S +S+T QG NN +  KS AYD+             SP+   +  ++CE    S +AED    VT KSF T GSLLP  + RT+SLPVDAVD+
Sbjct:   47 KKSYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTMKHNNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRQKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVREFVEKCLASVSLRLSARELLQDPFLRIDDCESDLRPIECRREPDDMVPLLRQPFLEYHHSNNSFSNGYSNAVDFDAHNGWGYQPLEMEPTGIELFEYHEDEHPANVDISIKGKRREDDGIFLRLRIADKEDHIRNIYFPFDIEMDTALSVATEMVAELDITDQDVTKIADMIDGEIASLVPEWKPGPGIEETPCFATLNLCHNCVSNHTSNGSLMDILANNPGAKNLQIFQ-CSNGCAAMHGRFEEITYQVDGADHHIPEG------QSEELHCTEIWYKHESRELSSVSSGESPSDEEYEKINHSI-IKDERG-SGTGNVASNVKNSISHLRNPSSSSAIPSMSCALSDDYENEIQQVLRWLKAKHQMEMRGLRDLQLGFASKPSSLDNRQLKPDNEGLFSTLSNTSQGHNNGLFLKSSAYDKHFTSNCATQVNKCSPDLVTHGARNCEANKGSRSAEDMVHVVTAKSFYTAGSLLPCPIHRTMSLPVDAVDI 752          

Query:    1 MNGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQGFCHNCASNHTSSGSMMEFLSNHPSAKNLQVLQCCKQGCASMHGRFEEVTYQA-DESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEIQ-EFRWLKAKHQMELRELRDQQIRLVSKSSDNGSK---EHELANGVLSSLVSSTLQGLNNVMLSKSCAYDQRNLSPNFHANLNKSCEVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVDV 2202
            MN + + +  DS+FVEVDPTGRYGRY+EILGKGASKTVYRAFDEY+GIEVAWNQ+KLYDFLQ+PEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTE+FTSGTL+QYRLKHKRVNIRAVKHWCRQIL+GL YLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEE YNELVDIYSFGMC+LEMVTFEYPYSEC+HPAQIYKKV SGKKPDALYKVKDPEVR+FVEKCLATASLRLSARELL+D FL+ID+ ++DL  VD G +  D+GPL+ Q  F + R               +   +W   P + E  GIELF          VDISIKGKR++DGGIFLRLRIADKE  IRNIYFPFDIE DTA SVATEMVAELDITDQDVT IA MIDGEIA LVP+W+PGPGI ET  Y+NQ FC NC SNHT+     + L  + SAKNL +LQCC  GCASMHGRFEE+T+Q+ D  + HV+E APN SS+SD L YQE W QHESRELS + S +SHSD +YE LD+   +ED+++   E++ A +AGNS K+LSG+H  S I S Y  + + +E EIQ E RWLKAK+QMEL EL+D+Q+ + +KS     K   E E  NG  + +     +  ++   S+     ++   PN      ++C V+ S   ED  T KSF T   LP +L RT+SLPVDAVDV
Sbjct:    1 MNCVTQLETDDSDFVEVDPTGRYGRYHEILGKGASKTVYRAFDEYQGIEVAWNQIKLYDFLQNPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTELFTSGTLRQYRLKHKRVNIRAVKHWCRQILQGLHYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEEYNELVDIYSFGMCVLEMVTFEYPYSECSHPAQIYKKVSSGKKPDALYKVKDPEVREFVEKCLATASLRLSARELLDDPFLRIDDDEYDLGSVDVG-EFGDLGPLVSQSFFSIDRSYSNISTEYSNGFGYEV--DWYSQPTEIE-HGIELFECHDDEPSKDVDISIKGKRKDDGGIFLRLRIADKEDHIRNIYFPFDIELDTALSVATEMVAELDITDQDVTSIAHMIDGEIASLVPEWRPGPGIDETINYSNQSFCDNCVSNHTTD---TDSLLRNQSAKNLHLLQCCMHGCASMHGRFEEITFQSEDYDDIHVSEDAPNISSKSDFLQYQESWNQHESRELSPVESTRSHSDEQYELLDKSFLIEDKREGIRENSFAPNAGNSLKDLSGNHYLSTIGSLYCGVENDYEKEIQHELRWLKAKYQMELWELKDKQLGVEAKSPHIEHKTPPETETVNGFDNGIHFHNYKDCDSSYNSR-----EQKSHPNLDTRRVQNCGVICS-KEEDMATAKSFYTRLFLPDTLHRTISLPVDAVDV 726          

Query:    1 MNGLVEPDYSDSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASLRLSARELLNDQFLQIDECDHDLRPVDYGRQIDDMGPLLRQPLFELHRXXXXXXXXXXXXXXXDSQNEWGYHPVDAESSGIELFXXXXXXXXXXVDISIKGKRREDGGIFLRLRIADKEGRIRNIYFPFDIETDTAFSVATEMVAELDITDQDVTRIADMIDGEIALLVPDWQPGPGIVETPRYANQ-GFCHNCASNHTSSGSMMEFLS-NHPSAKNLQVLQCCKQGCASMHGRFEEVTYQADESEHHVTEGAPNESSQSDCLHYQEIWGQHESRELSSIGSGQSHSDGEYEKLDQLVTVEDEQDLELESNPASHAGNSTKNLSGSHSFSVIPSTYHDLSDTHENEI-QEFRWLKAKHQMELRELRDQQI----RLVSKSSDNGSKEHELANGVLSSLVSSTLQGLNNVMLSKS--CAYDQRNLSPNFHANLNKSC------------EVMVSPNAEDEVTGKSFCTGSLLPQSLRRTVSLPVDAVD 2199
            M G +EPDYS  EFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKL DFLQSPE+LERLYCEIHLLKTLKH NIMKFYTSWVD ANRNINFVTEMFTSGTL+QYRLKH+RVNIRAVKHWCRQILRGLLYLH+H PPVIHRDLKCDNIF+NGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEE YNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKV+SGKKPDALYKVKDPEVRQFVEKCLAT +LRLSARELL D FLQ D+   DLRP++Y R + ++GPL R P + +H                + +N    HPV+ E + I+LF          VDISI+G++R+D GIFLRLRI+DKEGR+RNIYFPFD+ETDTA SVA EMV+ELDITDQDVT+IADMID EIA LVP W+ G GI E+  Y +   FCH+CASN    GS ++++S N+P  KNLQVLQC +QGCA++HGRFEE+TY+ + SE  VTEGAP  SSQSD + Y +IW Q E  ELSS GS +  SD E+E LD+ +  +DE+ + +++   S+A NS   L                 D +ENEI QE RWLKAK+QM+LRELRDQQ+    + +S + ++ S EH   N V  S +S+ L+G +N    KS  C    ++ +  F  +  + C             V  S + ED VT KSF TG+LLPQSL R  SLPVDAVD
Sbjct:    1 MFGELEPDYS--EFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLNDFLQSPEELERLYCEIHLLKTLKHNNIMKFYTSWVDPANRNINFVTEMFTSGTLRQYRLKHRRVNIRAVKHWCRQILRGLLYLHNHKPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVRQFVEKCLATVTLRLSARELLKDPFLQSDDYGSDLRPIEYQRDLGEVGPLPRLPHYGIHHSYSSLRNEYSGYPDFEPENGLDCHPVEFERNEIDLFTYQEDEHLENVDISIEGRKRDDHGIFLRLRISDKEGRVRNIYFPFDMETDTALSVAMEMVSELDITDQDVTKIADMIDDEIASLVPGWKMGLGIEESQNYGHDASFCHHCASN----GSPLDYVSPNNPGTKNLQVLQCSRQGCAAVHGRFEEITYRVEGSEQCVTEGAPVVSSQSDGMQYADIWAQREGPELSSEGSREIQSDEEHESLDKSIYGKDERVINIDNQSESNAKNSFAPL-----------------DDYENEIRQELRWLKAKYQMQLRELRDQQLGAKPKWLSLTPNSDSMEHSRDNKVSPSSLSTPLEGEDNDPPLKSFPCG---KHFNSFFPVDTERGCANLAYRRPHNREPVSESCSPEDMVTAKSFFTGTLLPQSLHRATSLPVDAVD 728