ppa002647m, ppa002647m (mRNA) Prunus persica

Query:   37 NGMLSKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSLWGSALSGVPASSGVEQDGSCCDNPETVNCNGGITSYPSFADFADEHSKVSVESAVLVDDASTKNDKVAESVDCSNTDGSCMCSFFYDIKFQSNY-ASNAEECSLVNGITDKLVFPLLEIEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKKKV 1938
            +G++ +     +EA YVE+DP+ RYVR+ EILGKGAFKTVYKAFDEVDGIE+AWNQVKID VLRSPEDLEKLYSEVHLLKSL HENIIKFYNSWVD+ K T+NMITELFTSGSLRQYRKK+KNVD KAI+NWARQ+LRGLV+LHSHNPPIIHRDLKCDNIF+NGNHGEVKIGDLGLA VMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPY+ECK+PAQI+KKVTSGIKPASL KV DLQIKEFI KCL  ASERL AKELLKDPF Q +NP EPIR PL                        D+                 VLEFQR  K+++FRL   K +D+S+SLTLR   + G V+NIHF F L TDT  SV  EMVEQL+L +H+VAFIA+FIDY+IM+LLPGWK                           L G  + +         +N +    +G   S P+ A+  D+ S  S     L  DAS KNDK                  F D     NY  SN    S                +  +             ++ D D  LK ELD I+ QYQ WF+ELSRMR +ALE T+KRW+ KKK+
Sbjct:    5 HGLVMQGAEDEDEAAYVEKDPTGRYVRFKEILGKGAFKTVYKAFDEVDGIEIAWNQVKIDDVLRSPEDLEKLYSEVHLLKSLKHENIIKFYNSWVDDKKKTVNMITELFTSGSLRQYRKKHKNVDMKAIKNWARQVLRGLVYLHSHNPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYNECKNPAQIYKKVTSGIKPASLCKVTDLQIKEFIVKCLAPASERLPAKELLKDPFFQSENPKEPIRVPLH----------------------PDF----------------PVLEFQRMYKSSEFRLRAKKINDNSISLTLRTVDSYGPVKNIHFPFSLDTDTVHSVVGEMVEQLELAEHEVAFIADFIDYVIMRLLPGWKPPR---------------------DDPLGGARSPNAEPPVLGNGNNHDCTISHGDGNSSPNLANAEDQDSLASAGLVTLTVDASKKNDKTVG---------------FGDYNIGGNYKGSNGGHAS---------------EQESRDPYHEDYKLQRNNSNIDQDPGLKQELDAIDLQYQHWFQELSRMRVEALEATKKRWMTKKKL 550          

Query:   43 MLSKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSP--QVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            +L    P  +++D+ E+DP+ RYVRYNE LGKGAFKTVYKAFDEVDGIEVAW QV+I+ +L+SP+ LE+LYSEVHLLKSL H+NIIKFYNSWVD+   TIN+ITELFTSGSLRQYRKK+KNVD KAI+NWA+QILRGL +LHSHNPPIIHRDLKCDNIF+NGN+GEVKIGDLGLA VMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMC+LE+VT EYPY+ECK+PAQI+KKV+SGIKPASLGKV+D Q+K+FIEKCLV AS RLSA+ELLKD F   +N  EP                        + + T     S+ST   S +G+P  + L+F+R NKNN F+L G K DD+S+S+TL IA  CG+ +NIHF FYL +DTA+S+  EMVEQL L + DVA IAE ID +I +L+P WK
Sbjct:  139 VLKNHTPLTDDSDFEEKDPTGRYVRYNEFLGKGAFKTVYKAFDEVDGIEVAWGQVEIEDLLQSPQQLERLYSEVHLLKSLKHDNIIKFYNSWVDDTNKTINLITELFTSGSLRQYRKKHKNVDLKAIKNWAKQILRGLHYLHSHNPPIIHRDLKCDNIFVNGNNGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCEYPYNECKNPAQIYKKVSSGIKPASLGKVSDPQVKQFIEKCLVPASLRLSAQELLKDAFFATENSKEP------------------------LSVST---HKSMSTHMKSISGTPHFRALQFERFNKNNLFKLRGEKIDDNSISMTLHIADPCGRAKNIHFAFYLDSDTALSIAGEMVEQLDLYNEDVAVIAELIDVMISELVPTWK 539          

Query:   58 KPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            +PP  + D +E DP++RY+R+ +ILGKGAFKTVYKAFD+VDGIEVAWNQV+ID VL+SP++LE+LYSEVHLLKSL H+NIIKFYNSW+D+   T+N+ITELFTSGSLRQYRKK+K VD KA++ WARQIL GL +LH+HNPPIIHRDLKCDNIFINGN GEVKIGDLGLATVMQQ  AR+VIGTPEFMAPELY+E YNEL DIYSFGMCMLEMVT EYPYSEC++ AQI+KKV++GIKPA+L K+ DL++K FIEKCLV AS+RLSAK+LL DPF QVD   +    PLQLP+  L +I        SMD   D    S+             +E QR    N F L G  ND++S+SL LRIA   G++RNIHF FYL +DTA+SV+SEMVEQL+L D +V FIAE ID L++ L+P WK
Sbjct:   17 EPP--DPDVLEIDPTSRYIRFKDILGKGAFKTVYKAFDQVDGIEVAWNQVRIDEVLQSPDELERLYSEVHLLKSLKHKNIIKFYNSWIDDGNKTVNIITELFTSGSLRQYRKKHKKVDMKAVKGWARQILMGLNYLHNHNPPIIHRDLKCDNIFINGNQGEVKIGDLGLATVMQQANARTVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTLEYPYSECRNSAQIYKKVSNGIKPAALSKIKDLEVKMFIEKCLVPASQRLSAKKLLNDPFFQVDGLTK--NHPLQLPD-ILPIIT-------SMDNSVDGGPYSL------------CMEVQRAKGGNFFLLKGEGNDENSISLILRIADQNGRLRNIHFMFYLDSDTALSVSSEMVEQLELADQNVTFIAELIDLLLIMLIPTWK 413          

Query:   49 SKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQP-TARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQ-LPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGW 1317
            S+  P + + ++VE DP+ RY RY E+LGKGAFK VY+AFDE++GIEVAWNQVK+  +LR+ E+ E+LYSEVHLLK+L H+NIIKFY SWVD     IN ITE+FTSG+LRQYRKK+K+VD +A++ W+RQIL GL++LHSH+PP+IHRDLKCDNIF+NGN GEVKIGDLGLA +++Q  +A SVIGTPEFMAPELYEEEYNELVDIY+FGMC+LE+VTFEYPY EC + AQI+KKVTSGIKPASL KV D +++ FI+KC+   S+RLSAKELL+DPFLQ D     +   LQ  P+ S                          +    N G+   +    ++++  F++ G + D +++ L LRIA + G +RNIHF F +  DTA+SV  EMVE+L LTD DV+ IA  ID  I  ++  W
Sbjct:    7 SEQDPDDPDTEFVEIDPTGRYGRYKEVLGKGAFKKVYRAFDELEGIEVAWNQVKVADLLRNSEEFERLYSEVHLLKTLKHKNIIKFYISWVDTRNENINFITEIFTSGTLRQYRKKHKHVDLRALKKWSRQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCLLELVTFEYPYVECANAAQIYKKVTSGIKPASLAKVKDPRVRAFIDKCIANVSDRLSAKELLRDPFLQSDEENGSVGRSLQPHPHHS-------------------------GSHDHFNTGTSSKVSLPESSRD--FKVQGQRRDVNTIFLKLRIADSKGHIRNIHFPFDIGADTAISVAGEMVEELDLTDQDVSTIAAMIDSEIRSIISDW 404          

Query:   76 ADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSM-DIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            +++VE DP+ RY RYNEILGKGA KTVY+AFDE +GIEVAWNQVK++  L+SPE+LE+LY E+HLLK+L H NI+KFY SWVD     IN +TE+FTSG+LRQYR K++ V+ +A+++W RQILRGL++LH+H PP+IHRDLKCDNIF+NGN GEVKIGDLGLA ++++  A   +GTPEFMAPE+YEEEYNELVDIYSFGMC+LEMVTFEYPYSEC  PAQI+KKV SG KP +L KV D ++++F+EKCL   + RLSA+ELLKDPFLQ D+    +R P++      +V  LP+     +  I+ +  ++ + T            +     +N    + G K DD  + L LRI+   G+VRNI+F F + TDTA+SV  EMV +L +TD DV  IA+ ID  I  L+PGWK
Sbjct:   12 SEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLNDFLQSPEELERLYCEIHLLKTLKHNNIMKFYTSWVDPANRNINFVTEMFTSGTLRQYRLKHRRVNIRAVKHWCRQILRGLLYLHNHKPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVRQFVEKCLATVTLRLSARELLKDPFLQSDDYGSDLR-PIEYQRDLGEVGPLPRLPHYGIHHIEFERNEIDLFT-----------YQEDEHLENVDISIEGRKRDDHGIFLRLRISDKEGRVRNIYFPFDMETDTALSVAMEMVSELDITDQDVTKIADMIDDEIASLVPGWK 415          

Query:   67 NEEAD----YVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            N EAD    +VE DP+ RY RYNEILGKGA KTVY+AFDE +GIEVAWNQVK+   L+SPEDLE+LY E+HLLK++ H NI+KFY SWVD     IN +TE+FTSG+LRQYR+K+K V+ +A+++W RQILRGL++LHSH+PP+IHRDLKCDNIF+NGN GEVKIGDLGLA ++++  A   +GTPEFMAPE+YEEEYNELVDIYSFGMC+LEMVTFEYPYSEC  PAQI+KKV SG KP +L KV D +++EF+EKCL   S RLSA+ELL+DPFL++D+    +R P++   +   ++      P  +++  +Y +                        N    + G + +DD + L LRIA     +RNI+F F +  DTA+SV +EMV +L +TD DV  IA+ ID  I  L+P WK
Sbjct:    6 NPEADDYSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTMKHNNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRQKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVREFVEKCLASVSLRLSARELLQDPFLRIDDCESDLR-PIECRREPDDMME-----PTGIEL-FEYHE-------------------DEHPANVDISIKGKRREDDGIFLRLRIADKEDHIRNIYFPFDIEMDTALSVATEMVAELDITDQDVTKIADMIDGEIASLVPEWK 401          

Query:   70 EEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQ-QPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKN-DDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            +E+ Y E DP+ RY R +E+LGKGA KTVYKA DEV G+EVAWNQVK++ VLRSP++L++LYSEVHLL +LNH++II+FY SW+D  + T N ITE FTSG+LR+YRKKYK VD +AI+ WARQILRGLV+LH H+PP+IHRDLKCDNIF+NG+ GEVKIGDLGLA +++   +A SVIGTPEFMAPELYEE YNELVD+YSFGMC+LEM+T EYPYSEC +PAQI+KKVTSG  P +  ++ DL+ + FI KCLV AS+RL AKELL DPFL  D       +  +LP   L         P   DI  +  +LS                  RTN      ++G  N DDD++ L ++ A   G  RNI+F F + TDT + V  EMV++L++TD +   IA+ ID  I  L+P WK
Sbjct:   15 DESGYAETDPTGRYGRLDEVLGKGAMKTVYKAIDEVLGMEVAWNQVKLNEVLRSPDELQRLYSEVHLLSALNHDSIIQFYTSWIDVERKTFNFITEFFTSGTLREYRKKYKRVDIRAIKCWARQILRGLVYLHGHDPPVIHRDLKCDNIFVNGHLGEVKIGDLGLAAILRGSQSAHSVIGTPEFMAPELYEENYNELVDVYSFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPGAFYRIQDLEAQRFIGKCLVTASKRLPAKELLLDPFLASD-------EAKRLPKPKLG-----SQKPFLNDIRIEKLRLSDDRV--------------RTNMT----ITGTLNPDDDTIFLKVQTADKDGSARNIYFPFDIVTDTPIDVAMEMVKELEITDWEPFEIADMIDGEISALVPQWK 403          

Query:   70 EEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQ-QPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTN---KNNQFRLSGMKNDDD-SVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            ++  YVE DPS RY R+ EILGKGA KTVYKAFDE  G+EVAWNQVK++ V  SP+DL++LYSEVHLLK+L+H++I++F+ SW+D    T N I+E+FTSG+LR+YR+KYK VD  A++NWARQIL GL +LH H+PP+IHRDLKCDNIF+NG+ G+VKIGDLGLA +++    A SVIGTPEFMAPELYEEEY+ELVD+YSFGMC+LEM+T EYPY EC +PAQI+KKVTSG  P +  ++ D++ +EF+ +CL   ++RL AKELL DPFL VD+  +       LP                         L IS+   S NG+ + +   +TN   ++    ++G  N DD ++ L + I+   G  RNI+F F + +DT + V +EMV +L++TD +   IA+ I+  I  L+P WK
Sbjct:   15 QQFGYVETDPSGRYGRFREILGKGAMKTVYKAFDEFLGMEVAWNQVKLNDVFNSPDDLQRLYSEVHLLKNLDHDSIMRFHTSWIDLDGGTFNFISEMFTSGTLREYRQKYKRVDIGAVKNWARQILHGLAYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQHAHSVIGTPEFMAPELYEEEYDELVDVYSFGMCVLEMLTSEYPYCECSNPAQIYKKVTSGKLPEAFYRIEDVEAREFVGRCLEHVAKRLPAKELLMDPFLAVDHGEQ------MLP------------------------MLKISSQKPSPNGTVEKIPSFQTNPRKRSTDMTITGTINPDDYTIFLKVAISDKDGLSRNIYFPFDIGSDTPIDVAAEMVRELEITDWEPFEIAKMIEEEIFALVPSWK 406          

Query:   55 VKPPNEEAD---YVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGL-ATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPF 882
            V P   + D   +VE DP+ RY RYNE+LG GA K VY+AFD+ +GIEVAWNQVK+         +++L+SEV LLK+L  +NII  YN W +   NT+N ITE+ TSG+LR+YRKK+++V  KA++ W++QIL+GL +LH H P IIHRDL C N+FINGN G+VKIGD GL ATV +   A SV+GTPEFMAPELYEE+Y ELVDIYSFGMC LEMVT E PYSEC + A+I+KKV SG +P ++ KV D ++K FIEKCL +   R SA ELL DPF
Sbjct:    4 VSPDQSDRDSEPFVEVDPTRRYGRYNELLGCGAVKRVYRAFDQEEGIEVAWNQVKLRAFSDDKPMIDRLFSEVRLLKTLKDKNIIALYNVWRNEDHNTLNFITEVCTSGNLREYRKKHRHVSMKALKKWSKQILKGLDYLHRHEPCIIHRDLNCSNVFINGNVGKVKIGDFGLAATVGKSHVAHSVLGTPEFMAPELYEEDYTELVDIYSFGMCFLEMVTLEIPYSECDNIAKIYKKVISGARPRAMDKVRDPEVKAFIEKCLAKPRARPSASELLNDPF 283          

Query:   82 YVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVM-QQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPF 882
            +VE DP+ RY RY+++LG GA K VY+AFD+ +GIEVAWNQV++         +++L+SEV LL +L +E+II  Y+ W DN  NT+N ITE+ TSG+LR YRK++++V  KA++ W+RQ+L+GL +LH+H+P IIHRDL C NIFINGN G+VKIGDLGLA ++ +   A SV+GTPE+MAPELYEE+Y E+VDIYSFGMC+LEMVT E PYSEC + A+I+KKVTSG+ P ++ KV+D ++K FIEKC+ Q   R SA ELL DPF
Sbjct:  546 FVEVDPTGRYGRYSDLLGHGAVKKVYRAFDQEEGIEVAWNQVQLRNFSEDKSMVDRLHSEVKLLSTLKNESIIVLYSVWKDNEHNTLNFITEVCTSGNLRDYRKRHRHVSIKALKKWSRQVLKGLEYLHTHDPCIIHRDLNCSNIFINGNIGQVKIGDLGLAAIVGKNHLAHSVLGTPEYMAPELYEEDYTEMVDIYSFGMCLLEMVTMEIPYSECDNIAKIYKKVTSGVGPLAMNKVSDPEVKFFIEKCIAQPRARPSASELLNDPF 813          

Query:   10 GVGLVPPSSNGMLSKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSL----WGSALSGVPASSGVEQD---GSCCDNPE----------TVNCNGGI-----TSYPSFADFADEHSKVSVESAVLVDDASTKNDKVAESVDCSNTDGSC--MCSFFYDIKFQSNYA--------SNAEECSLV--NGITDKLVFPLLEIEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKKKVPVH 1947
            G  L   S+NG  S ++PP+ + D+VE DP++RYVRY+E+LGKGAFKTVYK FDEVDGIEVAWNQV+I  VLRSP+DLEKL+SEVHLL+SL HENI++  NSWVD+ K TINMITELFTSG+LRQYRKK+KNVD KAI+NWARQIL+GLV+LH HNPPIIHRDLKCDNIF+NG++G VKIGDLGLA +MQQPTA SVIGTPEFMA ELYEEEYNEL+DIYSFGMCMLEMVTFEYPYSEC++PAQI+KKVTSGIKPASLG V+D Q+KEFI KCLV ASERLSAKELLKDPFLQ  N +EP+RDPL LPNQ  K  +  KSGPLSMDID DYKQ+S STC GSNN   +  V E+QR +KN  F+L G ++DD+SVSLTLRIA + G+V NIHF FYL +DTA+SV SEMV+QL+L DHDVAFIAEFID+LIMKL PGWK                   + +     W S L+ V +   VEQ+   G     PE            N +G +      S PSF    D+ S+ S  S +LV+D S+K+D+++E  D  NTDG+C  +  +  + + + +Y+        S   EC  +  N    +  FP L      +                +D ELK ELD IE+QYQ WF +LSR RE+ALE T+KRW  KKK+PVH
Sbjct:    7 GGTLALASNNGTYSALEPPDAKGDFVETDPTSRYVRYDEVLGKGAFKTVYKGFDEVDGIEVAWNQVRIADVLRSPKDLEKLHSEVHLLRSLKHENIMELCNSWVDDKKKTINMITELFTSGNLRQYRKKHKNVDMKAIKNWARQILQGLVYLHGHNPPIIHRDLKCDNIFVNGHNGVVKIGDLGLAIIMQQPTATSVIGTPEFMATELYEEEYNELIDIYSFGMCMLEMVTFEYPYSECRNPAQIYKKVTSGIKPASLGNVSDPQVKEFILKCLVPASERLSAKELLKDPFLQPQNLVEPVRDPLLLPNQYPKSSSATKSGPLSMDIDADYKQISSSTCTGSNNEGTRFPVPEYQREHKNKVFKLKGKESDDNSVSLTLRIADSSGRVWNIHFLFYLDSDTALSVASEMVDQLELADHDVAFIAEFIDHLIMKLSPGWKLSSNYSLNELTSFYTASAALENSVACPWDSVLTTVLSQPAVEQEALSGMTTTPPEGSLQADDFNYNDNRDGAVFHINYHSSPSFGYMEDQDSQTSGVSEILVEDVSSKDDRISELPD-YNTDGNCKYLNGYTSEPELRDSYSLRKLERNDSGVGECIPMNENAKVSETPFPKLSGAPNDMSMTSSSSSSLYLVGKSMDTELKLELDAIEAQYQNWFRDLSRRREEALESTKKRWTAKKKLPVH 687          

Query:   37 NGMLSKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSLWGSALSGVPASSGVEQDGSCCDNPETVNCNGGITSYPSFADFADEHSKVSVESAVLVDDASTKNDKVAESVDCS---NTDGS---------CMCSFFYDIKFQSNYASNAEECSLVNGITDKLVFPLLEIEA-PKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKKKVPV 1944
            +G++ +     +EA YVE+DP+ RYVR+ EILGKGAFKTVYKAFDEVDGIE+AWNQVKID VLRSPEDLEKLYSEVHLLKSL HENIIKFYNSWVD+ K T+NMITELFTSGSLRQYRKK+KNVD KAI+NWARQ+LRGLV+LHSHNPPIIHRDLKCDNIF+NGNHGEVKIGDLGLA VMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPY+ECK+PAQI+KKVTSGIKPASL KV DLQIKEFI KCL  ASERL AKELLKDPF Q +NP EPIR PLQLP++S K I L KSGP SMDID D+ QLS ST +  NNGSP   VLEFQR  K+++FRL   K +D+S+SLTLR   + G V+NIHF F L TDT  SV  EMVEQL+L +H+VAFIA+FIDY+IM+LLPGWK                           L G  + +         +N +    +G   S P+ A+  D+ S  S     L  DAS KNDK     D +   N  GS             +  D K Q N  S+ EE + +N      V    ++     V            AD D D  LK ELD I+ QYQ WF+ELSRMR +ALE T+KRW+ KKK+ V
Sbjct:    5 HGLVMQGAEDEDEAAYVEKDPTGRYVRFKEILGKGAFKTVYKAFDEVDGIEIAWNQVKIDDVLRSPEDLEKLYSEVHLLKSLKHENIIKFYNSWVDDKKKTVNMITELFTSGSLRQYRKKHKNVDMKAIKNWARQVLRGLVYLHSHNPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYNECKNPAQIYKKVTSGIKPASLCKVTDLQIKEFIVKCLAPASERLPAKELLKDPFFQSENPKEPIRVPLQLPSRSPKSIILSKSGPFSMDIDPDHPQLSSST-STENNGSPDFPVLEFQRMYKSSEFRLRAKKINDNSISLTLRTVDSYGPVKNIHFPFSLDTDTVHSVVGEMVEQLELAEHEVAFIADFIDYVIMRLLPGWKPPR---------------------DDPLGGARSPNAEPPVLGNGNNHDCTISHGDGNSSPNLANAEDQDSLASAGLVTLTVDASKKNDKTVGFGDYNIGGNYKGSNGGHASEQESRDPYHEDYKLQRN-NSSIEEFTPMNKFQKSTVLSFDDLSGLSNVRSLTCSCSSLSLADIDQDPGLKQELDAIDLQYQHWFQELSRMRVEALEATKKRWMTKKKLAV 632          

Query:    1 MDTGVGLVPPSSNGMLSKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVY------KAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSL----WGSALSGVPASSGVEQDGSCCDNPE-----TVNCNGGITSYPSFADF------------ADEHSKVSVESAVLVDDASTKNDKVAES-VDCSNTDGSCMCSFFYDIKFQSNYASNAEECSLVNGITDKLVFP----LLEIEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKKKV 1938
            M++G  L  P  + +    +P + E D+VE+DP+ RY+R NEILG+GAFKTVY      + FDEVDGIEVAWNQVKID ++ S +DL KLYSEV+LLKSL HENIIKFY+SW+D+ K T+NMITELFTSG+LRQYRKK+K V+ KAI+ WARQIL GLV+LHSH PPIIHRDLKCDNIF+NGN GEVKIGDLGLA VMQQPTA+SVIGTPEFMAPELYEE Y ELVDIYSFGMC+LEMVT EYPYSEC++PAQIFKKVTSGIKPASL KV+D Q+K+FIEKCLV ASERLSA ELLKDPFLQV+NP +PI  PLQ P+++L+  +  KSG LSMD+D+DYK  S+S  + SN  +P   + E QRT KNN+FRL G KND +SVSLTLRIA  CG+VRNIHF FY  TDTAVSV +EMVE L+L DHDV FIAE IDYLIMKLLP WK                     +L    WGS  + +P+   + QDG    +        V+ N  ++   + A F             D +S+ S  S +++++ S KND   +S  D S+   S   S   D+ F+       E C     + ++  FP     +   +  V             + D+D  LK +LD IE+ YQ W +EL+ M  +ALE TR+RW+ KKK+
Sbjct:   31 MNSGAVLALPPVSNVFRTREPHDFEDDFVEKDPTGRYIRNNEILGRGAFKTVYDSDAYYRGFDEVDGIEVAWNQVKIDGLMHSVDDLAKLYSEVNLLKSLKHENIIKFYDSWIDDKKKTVNMITELFTSGNLRQYRKKHKYVEMKAIKGWARQILHGLVYLHSHKPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAIVMQQPTAQSVIGTPEFMAPELYEEAYTELVDIYSFGMCILEMVTLEYPYSECQNPAQIFKKVTSGIKPASLNKVSDPQLKDFIEKCLVPASERLSADELLKDPFLQVENPKDPILYPLQPPSRTLRAYSF-KSGSLSMDMDSDYKPFSMSIYSESNQENPHCPIFEVQRTYKNNKFRLKGTKNDVNSVSLTLRIADTCGRVRNIHFLFYPDTDTAVSVATEMVEHLELADHDVDFIAELIDYLIMKLLPWWKPSPDHCSCGELSPYCTNIDGQTLMAWPWGSVSTSIPSELVIGQDGFSGSDTTPKEDFVVSENSSVSKIANNATFEGDCNSSSLVKLEDRYSQGSRASEMIIENTSMKNDNCHDSNDDLSSKCFSSSMSELRDVYFEDCKLQQTEYCVGEGVVINE--FPKNSGSVLGTSINVENLASSCSYVSSTEEDIDLGLKFKLDEIEAHYQHWIDELNEMMLEALESTRRRWMAKKKL 707          

Query:   55 VKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNP-MEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            ++P +  AD VE+DP+ RYVRY+++LGKGAFKTVY+AFDEVDGIEVAWNQV+ID VLRSPED EKLYSEV+LL+SL HENIIKF NSWVD+   TINMITELFTSG+LRQYR+K++N+D KAI+NWARQILRGLV+LH H+PPIIHRDLKCDNIF+NGNHGEVKIGDLGLA VMQ PTA+SVIGTPEFMAPELYEEEYNELVDIYSFGMC+LE+VT  YPYSEC++ AQI+KKVTSGIKPASL  V + QIKEFIEKCL+ ASERLSAKELLK PFLQ++ P +E I DPL +P+Q    ++LPKSGPL MD+D D KQLS STC GSNNGSP+  VLE+QR +KNN+F L GMKNDD+S SLTLRI+   G+VRNIHF FYL +DTA+SV SEMVEQL+L DHDVAFIAE ID LI+KLLPGWK
Sbjct:    1 MEPSDAGADLVEKDPTGRYVRYDDVLGKGAFKTVYRAFDEVDGIEVAWNQVRIDDVLRSPEDFEKLYSEVYLLRSLRHENIIKFSNSWVDDKNKTINMITELFTSGNLRQYRRKHRNIDIKAIKNWARQILRGLVYLHGHSPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQNPTAKSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCNYPYSECRNAAQIYKKVTSGIKPASLKTVGNTQIKEFIEKCLLPASERLSAKELLKHPFLQLEIPILEQICDPLPVPDQFPISLSLPKSGPLFMDMDIDEKQLSESTCTGSNNGSPKSPVLEYQRAHKNNEFGLKGMKNDDNSASLTLRISDLGGRVRNIHFIFYLDSDTAISVASEMVEQLELADHDVAFIAELIDSLIVKLLPGWK 425          

Query:   70 EEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEP---------IRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSP--QVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSLWGSALSGVPASSGVEQDGSCCDNPETVNCNGGITSYPS---FADFADEHSKVSVESAV----LVDDASTKND----KVAESVDCSNTDGSCMCSFFYDIKF-------QSNYASNAEECSLVNGITDKLVFPLLE-IEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKKK 1935
            +++D+ E+DP+ RYVRYNE LGKGAFKTVYKAFDEVDGIEVAW QV+I+ +L+SP+ LE+LYSEVHLLKSL H+NIIKFYNSWVD+   TIN+ITELFTSGSLRQYRKK+KNVD KAI+NWA+QILRGL +LHSHNPPIIHRDLKCDNIF+NGN+GEVKIGDLGLA VMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMC+LE+VT EYPY+ECK+PAQI+KKV+SGIKPASLGKV+D Q+K+FIEKCLV AS RLSA+ELLKD F   +N  EP         + D LQ  N    ++NLPK     MD+D +YK+LS+ST   S +G+P  + L+F+R NKNN F+L G K DD+S+S+TL IA  CG+ +NIHF FYL +DTA+S+  EMVEQL L + DVA IAE ID +I +L+P WK                     S+   A S    S  +   G+   +P       G +   +    +  A+   + +VESA+      DDA+  +D    K  E  D    + S  C F  D +        +  Y  N  E   +NG T       +E                   AD D   ELK E+DTI++QY + F+EL RMRE+A+E  + RWI K +
Sbjct:    9 DDSDFEEKDPTGRYVRYNEFLGKGAFKTVYKAFDEVDGIEVAWGQVEIEDLLQSPQQLERLYSEVHLLKSLKHDNIIKFYNSWVDDTNKTINLITELFTSGSLRQYRKKHKNVDLKAIKNWAKQILRGLHYLHSHNPPIIHRDLKCDNIFVNGNNGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCEYPYNECKNPAQIYKKVSSGIKPASLGKVSDPQVKQFIEKCLVPASLRLSAQELLKDAFFATENSKEPLSVSTHKSSVDDSLQSSNFMPNLMNLPKPELQPMDMDPNYKKLSVSTHMKSISGTPHFRALQFERFNKNNLFKLRGEKIDDNSISMTLHIADPCGRAKNIHFAFYLDSDTALSIAGEMVEQLDLYNEDVAVIAELIDVMISELVPTWK-----------------PAFESMLCGANSSCEDSLVLHNGGTSLRHPSDSGSAKGTSDAVTEHLISLSANGEEQSTVESALSGMSTKDDATVASDANDIKSLECPDDECYEASDRCCFNGDRQVLDHERHKEGRYNGNIGEPVAMNGFTKDWEISCIESCSGMSNSLSLSSICSLSLADKDPSDELKLEVDTIDTQYHQCFQELLRMREEAIEKAKNRWITKSR 643          

Query:   79 DYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSLWGSALSGVPASSGVEQDGSCCDNPETVNCNGGITSYPSFADFADEHSKVSVESAVLVDDASTKNDKVAESVDCSNTDGSCMCSFFYDIKFQSNYASNAEECSLVNGITDKLVFPLLEIEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEK 1929
            ++ E+DP+ RYVRY+EILGKGAFKTVYKAFDEVDGIEVAWNQV I+ VL+S + LE+LYSEVHLLKSL HENIIKFYNSWVD+   TINMITEL TSG+LRQYRKK+K VD KAI+NWARQILRGL +LH+ +P IIHRDLKCDNI +NGN+GEVKIGDLGLA VMQQP ARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVT EYPYSECK+PAQI+KKVTSGIKPASL KVNDLQ+KEFIEKCLV AS RLSA +LLKDPFL  +N  E +    QLPN   K ++LP+S    MDID   K LS+ +C  S N SPQ   LE +R  +NN+FRL   KNDD++VSLTLRIA  CG+ RNIHF FYL +DTAVS+  EMVEQL L+  DVA IAE ID LI+KL+P W                                  SS V    S  +N  T    G    +    +  D  +  SV S    D ++  N  +A     + + GS  CS       QSN   + + CS   G++      ++                   AD D  +ELK ELD+I+S Y + F+EL + RE+A+E  ++RWI K
Sbjct:   13 EFAEKDPTGRYVRYDEILGKGAFKTVYKAFDEVDGIEVAWNQVDIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYNSWVDDKNKTINMITELLTSGNLRQYRKKHKTVDMKAIKNWARQILRGLQYLHTRSPRIIHRDLKCDNILVNGNNGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVTSGIKPASLVKVNDLQVKEFIEKCLVPASVRLSAIDLLKDPFLATENSKEVVSSLSQLPNVICKQVHLPQSESHHMDIDC--KMLSLGSCPKSINESPQFLTLELRRFTENNEFRLRAEKNDDNTVSLTLRIADPCGRARNIHFTFYLNSDTAVSIAEEMVEQLDLSSEDVAVIAELIDSLIVKLVPCWN--------------------------------TSSSVRNGSSELENHATSE-TGKTPDFSPLTNITDHEALQSVNS----DISAEYNMAIASDASTNKSLGSSSCS------LQSN-VFHIDSCS---GMSRNASLSII--------------CSLFLADKD-GSELKLELDSIDSHYNQCFQELMKTREEAIENAKRRWISK 567          

Query:   82 YVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSLWGSALSGVPASSGVEQDGSCCDNPETVNCNGGITSYPSF---ADFADEHSKVSVESAVLVDDASTKNDKVAESVDCSNTDGS---CMCSFFYDIKFQSNYASNAEECSLVNGITDKLVFPLLEIEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKK 1932
            + E+DP+ RY+R +E LGKGAFKTVYKAFDEVDGIEVAWNQV I+ VL+S + LE+LYSEVHLLKSL HENIIKFY+SWVD+   TIN+ITELFTSGS+RQYRKK+K VD KAI+NWARQILRGL +LH+H+PPIIHRDLKCDNIF+NGN GEVKIGDLGLA VMQQP ARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVT EYPYSECK+PAQI+KKV+SGIKPASLGKV+D Q+K FIEKCLV AS RL A ELLKDPFL  +N  E +   LQLPN   + ++L +S    MDID   K+LS+ +C  S N SPQ   LE  R  +NN+FRL G KN+D++VSLTLRIA  CG+ RNIHF FYL +DTAV +  EMVEQL L   DVA IAE ID LI KL+P W                                  S  V    S  +N  T          P F    +  D  +K SV S    D ++  N  +A     + + GS   C+ S  YD++F       ++         D  +     +     M           AD D  +ELK ELD+I+S Y +  +EL +MRE+A+E  +KR I KK
Sbjct:   14 FAEKDPTGRYIRNDEFLGKGAFKTVYKAFDEVDGIEVAWNQVNIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYSSWVDDKNKTINIITELFTSGSMRQYRKKHKTVDMKAIKNWARQILRGLHYLHTHSPPIIHRDLKCDNIFVNGNTGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVSSGIKPASLGKVSDHQVKVFIEKCLVPASTRLPAIELLKDPFLATENSKELVSSSLQLPNLISRQVHLLQSESHLMDIDC--KKLSVGSCTKSINESPQFSTLELSRFTENNEFRLRGAKNNDNTVSLTLRIADPCGRARNIHFTFYLDSDTAVLIAEEMVEQLDLLTEDVAVIAELIDNLIAKLVPSWN--------------------------------TSPSVRNGSSELENHSTSEA----VKKPDFLPLTNMTDLETKQSVNS----DISAEYNMAIASDSGTNKSLGSSDCCLQSNMYDLEFGMLEDGISKHNKSTRNSNDSYIGSFSGMSRNASM---SSICSLSLADKD-GSELKQELDSIDSHYNQCLQELMKMREEAIENAKKRGITKK 592          

Query:   70 EEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVL---EFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSL---WGSALSGVPASSGVEQ------DGSCCDNPETVNCNGGITSYPSFADFADEHSKVSVESAVLVDDASTKNDKVAESVDCSNTDGSCMCSFFYDIKFQSNYASNAEECSLVNGITDKLVFPLLEIEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKKKVPV 1944
            ++   VE+DP+ RY RY+E+LGKGAFKTVYKAFDEVDGIEVAWNQ+ I+ V++SP++LEKLYSEVHLLKSL HENIIK Y+SWVD   + INMITELFTSGSLRQYRKK+KNVD KAI+NWARQILRGL FLHSHNPP+IHRDLKCDNIF+NGN+G+VKIGDLGLA VMQQPTARSVIGTPEFMAPELYEEEYNELVD+YSFGMC+LEM+T EYPYSECK+PAQI+KKVTSGIKPASL +VND ++K+FIEKCLV AS RL A ELLKDPFL   N  E   D L LPN   K +N P   P  M+ID++ K  S ++    +  + QV    +  R  +NN+FRL G KN D ++SLTLRIA A G  RNIHF FY+ +DT +S+  EMVE L+L D DVA IAE I  +I KL+P WK                      L   W    +     S  E       DG   D  E+V+           +D + E+  V     +  D    + +       C  ++G              N   +   C   +G +++    ++   +P               D D   EL+ E++ IE QYQ+ F EL +MRE+A+E  +KRW  KK + V
Sbjct:    6 DDVGVVEKDPTLRYARYDEMLGKGAFKTVYKAFDEVDGIEVAWNQISIEDVMQSPQNLEKLYSEVHLLKSLKHENIIKMYSSWVDEKSSNINMITELFTSGSLRQYRKKHKNVDMKAIKNWARQILRGLCFLHSHNPPVIHRDLKCDNIFVNGNNGQVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDVYSFGMCILEMITCEYPYSECKNPAQIYKKVTSGIKPASLARVNDPEVKQFIEKCLVPASMRLPASELLKDPFLATGNTKEIYHDNLLLPNPPSKSLNPPTCEPHPMEIDSNVKHTSPASTVERDKETSQVSSNHDILRKTENNEFRLRGEKNADRTISLTLRIADANGGARNIHFPFYIDSDTTISIAEEMVEHLELKDEDVAVIAELIHNMIFKLVPDWKPLCENSSGTDNLYRPLEPQNEQLNCHWTLGSNNFDMKSMYEDLGHSQLDGEDQDKQESVS-----------SDISAEYGTV-----IATDAKGVEQNCFILHECCKGSNG-------------LNTNPDVRICGQEDGNSNQSENSVVSCCSPSENLDRLSKCSLTALDQDHLDELQLEIEAIEIQYQQSFRELMKMREEAIENVKKRWTSKKNISV 613          

Query:   67 NEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSP--QVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLP 1311
            ++++++ E+DP+ RYVRY+E+LGKGAFKTVYKAFDE++GIEVAWNQV ++ VL+SP+ LE+LYSEVHLLKSL HENI+KFYNSWVD++  TINMITELFTSGSLR+YRKK+KNVD KAI+NWARQILRGL +LHSHNPPIIHRDLKCDN+F+NGN+GEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMC+LEMVT EYPYSECK+PAQI+KKVTSGIKPASL KVND  +K FIEKC+V AS RL A ELLKDPFL  +NP E +   L LP+  LK ++  +S    MDID+++K+LS+ +C  S + S      EFQR    N+FRL G KNDD+++SLTLRI   CG V+NIHF FYL +DT +S+  EMVEQL L++ DVA IAE ID LI+KL+P
Sbjct:    8 DDDSEFEEKDPTGRYVRYDEVLGKGAFKTVYKAFDEINGIEVAWNQVSVEDVLQSPDQLERLYSEVHLLKSLKHENIMKFYNSWVDDNNKTINMITELFTSGSLRKYRKKHKNVDIKAIKNWARQILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILEMVTCEYPYSECKNPAQIYKKVTSGIKPASLCKVNDPLVKRFIEKCIVPASMRLPALELLKDPFLATENPKELVFASLHLPDLMLKQVSRGQSESYPMDIDSNHKKLSVGSCTKSMDESLHFSTSEFQRLTVKNEFRLRGEKNDDNTISLTLRIVDRCGGVKNIHFTFYLDSDTTLSIAEEMVEQLDLSNEDVAIIAELIDALILKLVP 424          

Query:  157 YKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYAC-GKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLP 1311
            Y+ FDEVDGIEVAWNQVKID ++ S +DL KLYSEV+LLKSL HENIIKFY+SW+D+ + T+NMITELFTSG+LR YRKK+K V+ KAI+ WARQIL GLV+LHSH PPIIHRDLKCDNIF+NGN GEVKIGDLGLA VMQQPTA+SVIGTPEFMAPELYEE Y ELVDIYSFGMC+LEMVT EYPYSECK+PAQIFKKVTSGIKPASL KV+D Q+KEFIEKCLV ASERLSA+ELLKDPFLQV+NP +PI  PLQ P+++L+  +  KSG LSMD+D+D K  S+S C+ SN  +P   V E QRTN  ++FRL G KNDD+SVSLTLRIA  C G+VRNIHF FYL TDTAVSV +EMVE L+L DHDV FIAE IDYLIMKLLP
Sbjct:    1 YRGFDEVDGIEVAWNQVKIDGLMHSVDDLAKLYSEVNLLKSLKHENIIKFYDSWIDDKQKTVNMITELFTSGNLRLYRKKHKYVEMKAIKGWARQILHGLVYLHSHRPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAVVMQQPTAQSVIGTPEFMAPELYEEAYTELVDIYSFGMCILEMVTLEYPYSECKNPAQIFKKVTSGIKPASLNKVSDPQLKEFIEKCLVPASERLSAEELLKDPFLQVENPKDPILYPLQPPSRTLRAYSF-KSGSLSMDMDSDCKPFSMSICSESNQENPHCPVFEVQRTNNKHEFRLKGTKNDDNSVSLTLRIADTCAGRVRNIHFLFYLDTDTAVSVATEMVEHLELADHDVDFIAELIDYLIMKLLP 387          

Query:   40 GMLSKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSP--QVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPG 1314
            G L KV    ++A+ VE DP+ RY+RYNE+LG+GA KTVYKAFDEV+GIEVAW+QV+ID V++SP++LE+LYSEVHLLKSL HEN++KFYN WVD+ K TIN+ITELFTSGSLRQYR+K+  VD KAI+NWARQ+LRGL +LH+H PPIIHRDLKCDNIF+NGNHGEVKIGDLGLATVM  P A+SVIGTPEFMAPELY+E Y+ELVDIYSFGMCMLEM T EYPYSEC + AQIFKKV+ G+KPA+L K+ ++Q K+FI+KCLV ASERLSAKELL+DPFL  DN    +    + P+   K +++     L MD+DT+ + +  STC  ++ G P   VLEF RTNKN + +L+G K DD+SVSL LRIA  CG  RNIHF FYL +DTA+SV +EMVEQL+L D DV FIA+FID LI+ L+PG
Sbjct:    5 GDLDKV----DDAECVEVDPTRRYIRYNEVLGRGAMKTVYKAFDEVEGIEVAWSQVEIDEVMQSPDNLERLYSEVHLLKSLKHENVMKFYNYWVDDQKKTINVITELFTSGSLRQYRQKHPRVDLKAIKNWARQVLRGLDYLHTHQPPIIHRDLKCDNIFVNGNHGEVKIGDLGLATVMLTPRAKSVIGTPEFMAPELYDENYDELVDIYSFGMCMLEMFTLEYPYSECTNAAQIFKKVSKGVKPAALAKITNIQAKQFIDKCLVPASERLSAKELLQDPFLCSDN--SSVLVGTKFPSSLPKSVDVSLEA-LHMDVDTN-ESMCTSTCKRNDLGGPHRSVLEFTRTNKNTELKLTGEKLDDNSVSLVLRIADLCGHARNIHFLFYLDSDTAMSVAAEMVEQLELADCDVTFIADFIDLLIVNLVPG 423          

Query:   58 KPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSG-------------------PLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            +PP+ E   +E DP+ RY+RY E++GKGAFKTVYKAFDEVDGIEVAWNQV+ID VL+SP  LE+LYSEV LLKSL H NII+FYNSW+D+   T+N+ITELFTSGSLR YRKK++ V+ KA++NWARQIL GL +LH   PPIIHRDLKCDNIFINGNHGEVKIGDLGLATVM+Q  A+SVIGTPEFMAPELY+E YNEL DIYSFGMCMLEMVTF+YPY ECK+ AQI+KKV+SGIKPASL +V D ++K+FIEKCL+ ASERLSAKELL DPFLQ++     + +PL LP+     I +PK G                    LS+D+D D   L I T   S+N   + +E +R  + N F L G +ND+ SVSL LRI    G+VRNIHF FY   DTA  V+SEMVEQL+LTD +V FIAE ID L++ ++P WK
Sbjct:   12 EPPDPEV--LEVDPTFRYIRYKEVIGKGAFKTVYKAFDEVDGIEVAWNQVRIDDVLQSPNCLERLYSEVRLLKSLKHNNIIRFYNSWIDDKNKTVNIITELFTSGSLRHYRKKHRKVNMKAVKNWARQILMGLRYLHGQEPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFDYPYCECKNSAQIYKKVSSGIKPASLSRVKDPEVKQFIEKCLLPASERLSAKELLLDPFLQLNG--LTMNNPLPLPD-----IVMPKEGAFGDRCLMSEGPPTTRPSKTLSIDLDED-SNLPIVTF--SDNSGSRCIEVRRAKRGNFFVLKGEENDEQSVSLILRIVDENGRVRNIHFLFYQEGDTASKVSSEMVEQLELTDQNVTFIAELIDILLVNMIPTWK 439          

Query:   31 SSNGMLSKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSP--QVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLL 1308
            S +G L ++    EEAD+ E+DPS RY+RY+++LG+GAFKTVYKAFDEVDGIEVAWN V I+ V++ P  LE+LYSEVHLLK+L HENIIK + SWVD    TINMITELFTSGSLR YRKK++ VD KAI+NWARQIL+GL +LHS NPP+IHRDLKCDNIF+NGN GEVKIGDLGLATV+QQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVT EYPY+EC++ AQI+KKVTS IKP SLGKV+D Q+++FIEKCL+ AS R +A EL KDPFL  D   +     L   + S K +  P+   L MD+D + +  S+S    SN   P  Q +E QR  +N +FRL G ++DD + S+ LRIA   GK R +HF FYL +DTA ++  EMVE+L LT  +V  IA+ ID  IM+LL
Sbjct:    3 SGSGFLGQISSM-EEADFAEKDPSGRYIRYDDVLGRGAFKTVYKAFDEVDGIEVAWNLVSIEDVMQMPGQLERLYSEVHLLKALKHENIIKLFYSWVDEKNKTINMITELFTSGSLRVYRKKHRKVDPKAIKNWARQILKGLNYLHSQNPPVIHRDLKCDNIFVNGNTGEVKIGDLGLATVLQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYNECRNQAQIYKKVTSNIKPQSLGKVDDPQVRQFIEKCLLPASSRPTALELSKDPFLARDGGKDSAL--LASSSTSSKYVRPPQLEHLPMDVDHN-ENKSVS----SNEDYPWSQTIELQRIAENKEFRLRGERSDDVTASMVLRIADPSGKCRIVHFAFYLESDTATAIAEEMVEELHLTSQEVVVIADMIDDFIMQLL 422          

Query:   55 VKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSG------------------PLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            V+PP+ E   +E DP+ RY+RY E++GKGA KTV+K FDEVDGIEVAWNQV+ID +L+SP+ LE+LYSEV LLKSL H+NII+FYNSW+D+   T+N+ITELFTSGSLRQYRKK++ V+ KA++ WARQIL GL +LHS +PPIIHRD+KCDNIFINGNHGEVKIGDLGLATVM+Q  A+SVIGTPEFMAPELY+E YNEL DIYSFGMCMLEMVTFEYPY EC++ AQI+KKV+SGIKPASL KV D ++ +FIEKCL+ ASERLSA+ELL D FL V+  +  + +PL LP+     I +PK G                   +SM++D D    ++     SNN     +E +R  + N F L G +ND++SVSL LRI    G+VRNIHF F+   DTA +V+SEMVEQL+LTD +V FIAE ID L++ L+P WK
Sbjct:   11 VEPPDPEV--LEIDPTCRYIRYKEVIGKGASKTVFKGFDEVDGIEVAWNQVRIDDLLQSPDCLERLYSEVRLLKSLKHKNIIRFYNSWIDDKNKTVNIITELFTSGSLRQYRKKHRKVNMKAVKCWARQILTGLKYLHSQDPPIIHRDIKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFEYPYCECRNSAQIYKKVSSGIKPASLSKVKDPEVMKFIEKCLLPASERLSAEELLLDSFLNVNGLV--MNNPLPLPD-----IVMPKEGSFGERCLMSEGPPNARNRTMSMNLDEDN---NLPIVISSNNSGTNCIEVRRAKRGNFFVLKGEENDENSVSLILRIVDENGRVRNIHFLFFQEGDTASNVSSEMVEQLELTDKNVKFIAELIDVLLVNLIPNWK 438          

Query:   70 EEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSP----QVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKL 1305
            EEAD+V++DP+ RY+RYN++LG+GAFKTVYKAFDEV+GIEVAWN + I+ VL+ P  L++LYSEVHLL SL H+NIIK + SWVD+H  +INMITELFTSGSL  YRKK++ VD KAI NWARQIL+GL +LHS  PP+IHRDLKCDNIF+NGN G+VKIGDLGLA VMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVT EYPY EC++ AQI+KKVTSGIKP SL KV+D Q+K+FIEKCL+ A  R +A ELLKD  L VD   +         N + K    P+     MD++   K  S+S C+ + +       Q +E QR  ++ +F+LSG + DD + S+ LRIA + G+ R + F F L TDTA +VT EMVE+L L+ H+V  IAE ID LIMKL
Sbjct:    2 EEADFVQKDPTGRYIRYNDVLGRGAFKTVYKAFDEVEGIEVAWNLMSIEDVLQMPGQLDRLYSEVHLLNSLKHDNIIKLFYSWVDDHNKSINMITELFTSGSLTLYRKKHRKVDPKAIMNWARQILKGLHYLHSQTPPVIHRDLKCDNIFVNGNTGKVKIGDLGLAAVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYRECRNQAQIYKKVTSGIKPQSLSKVDDPQVKQFIEKCLLPAPSRPTALELLKDQLLAVDGAKDSTLTASS--NTTFKPAMPPQCEYRPMDVEYK-KNTSVSICSSAKSSQECALLQTMEVQRVAESTEFKLSGERRDDVAASMALRIAGSSGQARKVDFDFNLKTDTARAVTGEMVEELDLSSHEVTVIAEMIDELIMKL 414          

Query:   79 DYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNP-----------MEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNK----NNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            +Y E DP+ RY RYN++LGKGA KTVY+AFDE  G+EVAWNQVK+   L+SPEDLE+LY E+HLLK+L H NI+KFY SWVD  +  IN ITE+FTSG+LRQYR+K+  V+  A+++W RQIL GL++LHSH+PPIIHRDLKCDNIF+NGN GEVKIGDLGLA ++++  A   +GTPEFMAPE+YEEEYNELVDIYSFGMC+LEMVTFEYPYSEC  P QI+KKV SG KP +L KV D  +++F+EKCL  AS RLSA+ELLKDPFLQVD+            M  +R P      +   +++  +G LS  ID D        C   +  +  +  F         N    + G K++D S+ L LRIA   G VRNI+F F +  DTA+SV +EMV +L +TDH+V  IAE ID  +  L+P W+
Sbjct:   16 EYAEVDPTGRYGRYNDVLGKGASKTVYRAFDEYQGMEVAWNQVKLHDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDVSRRNINFITEMFTSGTLRQYRQKHMRVNIWAVKHWCRQILSGLLYLHSHDPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAVHCVGTPEFMAPEVYEEEYNELVDIYSFGMCVLEMVTFEYPYSECTHPVQIYKKVISGTKPEALYKVKDPMVRQFVEKCLATASRRLSARELLKDPFLQVDDLVFCPGDGDYSLMNYLRQPYL--EHAYSNVSMMSNG-LSESIDEDTPTEDRWDCEDDDIKADGIDLFNGHEDEPLGNVDITIKGRKSEDGSIFLRLRIADNDGHVRNIYFPFDIEADTALSVATEMVAELDITDHEVTRIAEMIDGEVSALVPDWR 441          

Query:   79 DYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNP-----------MEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNK----NNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            +Y E DP+ RY RYN++LGKGA KTVY+AFDE  G+EVAWNQVK+   L+SPEDLE+LY E+HLLK+L H NI+KFY SWVD  +  IN ITE+FTSG+LRQYR+K+  V+  A+++W RQIL GL++LHSH+PPIIHRDLKCDNIF+NGN GEVKIGDLGLA ++++  A   +GTPEFMAPE+YEEEYNELVDIYSFGMC+LEMVTFEYPYSEC  P QI+KKV SG KP +L KV D  +++F+EKCL  AS RLSA+ELLKDPFLQVD+            M  +R P      +   +++  +G LS  ID D        C   +  +  +  F         N    + G K++D S+ L LRIA   G VRNI+F F +  DTA+SV +EMV +L +TDH+V  IAE ID  +  L+P W+
Sbjct:   16 EYAEVDPTGRYGRYNDVLGKGASKTVYRAFDEYQGMEVAWNQVKLHDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDVSRRNINFITEMFTSGTLRQYRQKHMRVNIWAVKHWCRQILSGLLYLHSHDPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAVHCVGTPEFMAPEVYEEEYNELVDIYSFGMCVLEMVTFEYPYSECTHPVQIYKKVISGTKPEALYKVKDPMVRQFVEKCLATASRRLSARELLKDPFLQVDDLVFCPGDGDYSLMNYLRQPYL--EHAYSNVSMMSNG-LSESIDEDTPTEDRWDCEDDDIKADGIDLFNGHEDEPLGNVDITIKGRKSEDGSIFLRLRIADNDGHVRNIYFPFDIEADTALSVATEMVAELDITDHEVTRIAEMIDGEVSALVPDWR 441          

Query:   73 EADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQP-TARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQ------FRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGW 1317
            E ++ E DP+ RY RY E+LGKGAFKTVYKAFD+++G+EVAWNQ+K+  +LR+ +DLE+L SEV LLK+L H+NIIKFYNSW+D   N IN ITE+FTSG+LRQYR K+K VD +A++ W+RQIL GLV+LHSH+PP+IHRDLKCDNIF+NGN GEVKIGDLGLAT++    +A S+IGTPEFMAPELY+EEYNELVDIY+FGMC+LE+VTFEYPY EC + AQI+KKV+ G KP+SL K+ D +++ FIEKC+ +AS+RLSA+ELL DPFL+ D   E I  PLQ   ++        S  +    D D   ++I    GS         +  +  + Q        +     D +++ L LRIA + G  +NIHF F +  DT++SV +EMV QL LTD DV  IAE ID  I   +P W
Sbjct:   15 EPEFAEVDPTARYGRYTEVLGKGAFKTVYKAFDQLEGLEVAWNQIKVGDILRNNDDLERLRSEVRLLKTLKHKNIIKFYNSWLDKKNNNINFITEVFTSGTLRQYRIKHKKVDVRALKKWSRQILSGLVYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLATILDNARSAHSIIGTPEFMAPELYDEEYNELVDIYAFGMCLLELVTFEYPYCECSNAAQIYKKVSDGEKPSSLAKIEDPEVRFFIEKCIAKASQRLSAQELLMDPFLRDDG--EKIFYPLQSNTKASDGAGSSNSS-MGYKYDRDASSMAIREHTGSFAEEHPSDRYIHSTMDPQAAAGRIITVESQMKDLNTIFLKLRIADSTGHAQNIHFPFDIEADTSISVATEMVVQLDLTDQDVTAIAEMIDAEIRAHIPDW 433          

Query:   67 NEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQP-TARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNG--SPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLT-DHDVAFIAEFIDYLIMKLLPGW 1317
            N E ++VE DP+ RY RY E+LGKGAFK VY+AFD+++GIEVAWNQVK+D    S EDL++LYSEVHLLK+L H++IIKFY SW+D+   TIN+ITE+FTSG+LRQYRKK+K VD +A++ W+RQIL GLV+LHSH+PP+IHRDLKCDNIFINGN GEVKIGDLGLA ++ +  +A SVIGTPEFMAPELYEE+YN LVDIY+FGMC+LE+VTFEYPYSEC + AQI++KVTSGIKPA+L  V D Q++ FIEKC+ + S+RLSAKELL DPFL+                                     YK+ + +  +   NG     +++    ++     + G + D +++ L LRI  + G++RNIHF F + TDT+ SV  EMVE+L LT D D++ IA+ ID  I   +P W
Sbjct:    7 NSEEEFVEIDPTGRYGRYKEVLGKGAFKEVYRAFDQLEGIEVAWNQVKLDDKFCSSEDLDRLYSEVHLLKTLKHKSIIKFYTSWIDHQHMTINLITEVFTSGNLRQYRKKHKCVDLRALKKWSRQILEGLVYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILHRARSAHSVIGTPEFMAPELYEEDYNVLVDIYAFGMCLLELVTFEYPYSECTNAAQIYRKVTSGIKPAALLNVTDPQVRAFIEKCIAKVSQRLSAKELLDDPFLKC------------------------------------YKENTENVSSHKENGYNGNGIVDKLSDSEVGLLTVEGQRKDLNTIFLKLRITDSKGQIRNIHFPFNIETDTSFSVAIEMVEELDLTDDQDISTIAKMIDTEIHSHIPDW 391          

Query:   46 LSKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDN--------PMEPIRDPL-QLPNQSLKVINLP-KSGPLSMDIDT-DYKQLSISTCAGSNNGSPQVLEFQ------------------------------RTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            LS ++P  + +++VE DP+ RY RYNE+LGKGA KTVY+AFDE +GIEVAWNQVK+   L+SPEDLE+LY E+HLLK+L H+NI+KFY SWVD     IN +TELFTSG+LRQYR ++K V+ +A+++W RQILRGL +LHSH+PP+IHRDLKCDNIF+NGN GEVKIGDLGLA ++++  A   +GTPEFMAPE+YEE YNELVDIYSFGMC+LEMVTF+YPYSEC  PAQI+KKV SG KP +L KV D ++K FIEKCL   S R+SA+ELL DPFL++D+         ME    PL + P+      N P  S  L+      +Y   S S     +NG     E+Q                              + + N    + G + DD  + L LRIA   G+VRNI+F F + TDTA+SV +EMV +L + DH V  IA  ID  I  L+P W+
Sbjct:    4 LSYLEP--DYSEFVEVDPTGRYGRYNEVLGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTELFTSGTLRQYRLRHKRVNIRAMKHWCRQILRGLHYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFDYPYSECTHPAQIYKKVMSGKKPDALYKVKDPEVKCFIEKCLATVSLRVSARELLDDPFLRIDDGEFDLRSVDMEDSVGPLYRQPHHLPDYYNYPSNSSSLNRQYSNGNYPSNSSSLNRQYSNGYNSHHEYQNGWAYNPAETEETHGIELFESRNNDDQEEEKKSGNVDITIKGKRRDDGGLFLRLRIADKEGRVRNIYFPFDIETDTALSVATEMVAELDMDDHGVTKIANMIDGEISSLVPSWR 467          

Query:   58 KPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSG-------------------PLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            +PP+ E   +E DP+ RY+RY E++GKGAFKTVYKAFDEVDGIEVAWNQV+ID VL+SP  LE+LYSEV LLKSL H NII+FYNSW+D+   T+N+ITELFTSGSLR YRKK++ V+ KA++NWARQIL GL +LH   PPIIHRDLKCDNIFINGNHGEVKIGDLGLATVM+Q  A+SVIGTPEFMAPELY+E YNEL DIYSFGMCMLEMVTF+YPY ECK+ AQI+KKV+SGIKPASL +V D ++K+FIEKCL+ ASERLSAKELL DPFLQ++     + +PL LP+     I +PK G                    LS+D+D D   L I T   S+N   + +E +R  + N F L G +ND+ SVSL LRI    G+VRNIHF FY   DTA  V+SEMVEQL+LTD +V FIAE ID L++ ++P WK
Sbjct:   12 EPPDPEV--LEVDPTFRYIRYKEVIGKGAFKTVYKAFDEVDGIEVAWNQVRIDDVLQSPNCLERLYSEVRLLKSLKHNNIIRFYNSWIDDKNKTVNIITELFTSGSLRHYRKKHRKVNMKAVKNWARQILMGLRYLHGQEPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFDYPYCECKNSAQIYKKVSSGIKPASLSRVKDPEVKQFIEKCLLPASERLSAKELLLDPFLQLNG--LTMNNPLPLPD-----IVMPKEGAFGDRCLMSEGPPTTRPSKTLSIDLDED-SNLPIVTF--SDNSGSRCIEVRRAKRGNFFVLKGEENDEQSVSLILRIVDENGRVRNIHFLFYQEGDTASKVSSEMVEQLELTDQNVTFIAELIDILLVNMIPTWK 439          

Query:   58 KPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSG-------------------PLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            +PP+ E   +E DP+ RY+RY E++GKGAFKTVYKAFDEVDGIEVAWNQV+ID VL+SP  LE+LYSEV LLKSL H NII+FYNSW+D+   T+N+ITELFTSGSLR YRKK++ V+ KA++NWARQIL GL +LH   PPIIHRDLKCDNIFINGNHGEVKIGDLGLATVM+Q  A+SVIGTPEFMAPELY+E YNEL DIYSFGMCMLEMVTF+YPY ECK+ AQI+KKV+SGIKPASL +V D ++K+FIEKCL+ ASERLSAKELL DPFLQ++     + +PL LP+     I +PK G                    LS+D+D D   L I T   S+N   + +E +R  + N F L G +ND+ SVSL LRI    G+VRNIHF FY   DTA  V+SEMVEQL+LTD +V FIAE ID L++ ++P WK
Sbjct:   12 EPPDPEV--LEVDPTFRYIRYKEVIGKGAFKTVYKAFDEVDGIEVAWNQVRIDDVLQSPNCLERLYSEVRLLKSLKHNNIIRFYNSWIDDKNKTVNIITELFTSGSLRHYRKKHRKVNMKAVKNWARQILMGLRYLHGQEPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFDYPYCECKNSAQIYKKVSSGIKPASLSRVKDPEVKQFIEKCLLPASERLSAKELLLDPFLQLNG--LTMNNPLPLPD-----IVMPKEGAFGDRCLMSEGPPTTRPSKTLSIDLDED-SNLPIVTF--SDNSGSRCIEVRRAKRGNFFVLKGEENDEQSVSLILRIVDENGRVRNIHFLFYQEGDTASKVSSEMVEQLELTDQNVTFIAELIDILLVNMIPTWK 439          

Query:   31 SSNGMLSKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSP--QVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLL 1308
            S +G L ++    EEAD+ E+DPS RY+RY+++LG+GAFKTVYKAFDEVDGIEVAWN V I+ V++ P  LE+LYSEVHLLK+L HENIIK + SWVD    TINMITELFTSGSLR YRKK++ VD KAI+NWARQIL+GL +LHS NPP+IHRDLKCDNIF+NGN GEVKIGDLGLATV+QQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVT EYPY+EC++ AQI+KKVTS IKP SLGKV+D Q+++FIEKCL+ AS R +A EL KDPFL  D   +     L   + S K +  P+   L MD+D + +  S+S    SN   P  Q +E QR  +N +FRL G ++DD + S+ LRIA   GK R +HF FYL +DTA ++  EMVE+L LT  +V  IA+ ID  IM+LL
Sbjct:    3 SGSGFLGQISSM-EEADFAEKDPSGRYIRYDDVLGRGAFKTVYKAFDEVDGIEVAWNLVSIEDVMQMPGQLERLYSEVHLLKALKHENIIKLFYSWVDEKNKTINMITELFTSGSLRVYRKKHRKVDPKAIKNWARQILKGLNYLHSQNPPVIHRDLKCDNIFVNGNTGEVKIGDLGLATVLQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYNECRNQAQIYKKVTSNIKPQSLGKVDDPQVRQFIEKCLLPASSRPTALELSKDPFLARDGGKDSAL--LASSSTSSKYVRPPQLEHLPMDVDHN-ENKSVS----SNEDYPWSQTIELQRIAENKEFRLRGERSDDVTASMVLRIADPSGKCRIVHFAFYLESDTATAIAEEMVEELHLTSQEVVVIADMIDDFIMQLL 422          

Query:   55 VKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSG------------------PLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            V+PP+ E   +E DP+ RY+RY E++GKGA KTV+K FDEVDGIEVAWNQV+ID +L+SP+ LE+LYSEV LLKSL H+NII+FYNSW+D+   T+N+ITELFTSGSLRQYRKK++ V+ KA++ WARQIL GL +LHS +PPIIHRD+KCDNIFINGNHGEVKIGDLGLATVM+Q  A+SVIGTPEFMAPELY+E YNEL DIYSFGMCMLEMVTFEYPY EC++ AQI+KKV+SGIKPASL KV D ++ +FIEKCL+ ASERLSA+ELL D FL V+  +  + +PL LP+     I +PK G                   +SM++D D    ++     SNN     +E +R  + N F L G +ND++SVSL LRI    G+VRNIHF F+   DTA +V+SEMVEQL+LTD +V FIAE ID L++ L+P WK
Sbjct:   11 VEPPDPEV--LEIDPTCRYIRYKEVIGKGASKTVFKGFDEVDGIEVAWNQVRIDDLLQSPDCLERLYSEVRLLKSLKHKNIIRFYNSWIDDKNKTVNIITELFTSGSLRQYRKKHRKVNMKAVKCWARQILTGLKYLHSQDPPIIHRDIKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFEYPYCECRNSAQIYKKVSSGIKPASLSKVKDPEVMKFIEKCLLPASERLSAEELLLDSFLNVNGLV--MNNPLPLPD-----IVMPKEGSFGERCLMSEGPPNARNRTMSMNLDEDN---NLPIVISSNNSGTNCIEVRRAKRGNFFVLKGEENDENSVSLILRIVDENGRVRNIHFLFFQEGDTASNVSSEMVEQLELTDKNVKFIAELIDVLLVNLIPNWK 438          

Query:   70 EEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSP----QVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKL 1305
            EEAD+V++DP+ RY+RYN++LG+GAFKTVYKAFDEV+GIEVAWN + I+ VL+ P  L++LYSEVHLL SL H+NIIK + SWVD+H  +INMITELFTSGSL  YRKK++ VD KAI NWARQIL+GL +LHS  PP+IHRDLKCDNIF+NGN G+VKIGDLGLA VMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVT EYPY EC++ AQI+KKVTSGIKP SL KV+D Q+K+FIEKCL+ A  R +A ELLKD  L VD   +         N + K    P+     MD++   K  S+S C+ + +       Q +E QR  ++ +F+LSG + DD + S+ LRIA + G+ R + F F L TDTA +VT EMVE+L L+ H+V  IAE ID LIMKL
Sbjct:    2 EEADFVQKDPTGRYIRYNDVLGRGAFKTVYKAFDEVEGIEVAWNLMSIEDVLQMPGQLDRLYSEVHLLNSLKHDNIIKLFYSWVDDHNKSINMITELFTSGSLTLYRKKHRKVDPKAIMNWARQILKGLHYLHSQTPPVIHRDLKCDNIFVNGNTGKVKIGDLGLAAVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYRECRNQAQIYKKVTSGIKPQSLSKVDDPQVKQFIEKCLLPAPSRPTALELLKDQLLAVDGAKDSTLTASS--NTTFKPAMPPQCEYRPMDVEYK-KNTSVSICSSAKSSQECALLQTMEVQRVAESTEFKLSGERRDDVAASMALRIAGSSGQARKVDFDFNLKTDTARAVTGEMVEELDLSSHEVTVIAEMIDELIMKL 414          

Query:  157 YKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSG------------------PLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            +K FDEVDGIEVAWNQV+ID +L+SP+ LE+LYSEV LLKSL H+NII+FYNSW+D+   T+N+ITELFTSGSLRQYRKK++ V+ KA++ WARQIL GL +LHS +PPIIHRD+KCDNIFINGNHGEVKIGDLGLATVM+Q  A+SVIGTPEFMAPELY+E YNEL DIYSFGMCMLEMVTFEYPY EC++ AQI+KKV+SGIKPASL KV D ++ +FIEKCL+ ASERLSA+ELL D FL V+  +  + +PL LP+     I +PK G                   +SM++D D    ++     SNN     +E +R  + N F L G +ND++SVSL LRI    G+VRNIHF F+   DTA +V+SEMVEQL+LTD +V FIAE ID L++ L+P WK
Sbjct:   25 FKGFDEVDGIEVAWNQVRIDDLLQSPDCLERLYSEVRLLKSLKHKNIIRFYNSWIDDKNKTVNIITELFTSGSLRQYRKKHRKVNMKAVKCWARQILTGLKYLHSQDPPIIHRDIKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFEYPYCECRNSAQIYKKVSSGIKPASLSKVKDPEVMKFIEKCLLPASERLSAEELLLDSFLNVNGLV--MNNPLPLPD-----IVMPKEGSFGERCLMSEGPPNARNRTMSMNLDEDN---NLPIVISSNNSGTNCIEVRRAKRGNFFVLKGEENDENSVSLILRIVDENGRVRNIHFLFFQEGDTASNVSSEMVEQLELTDKNVKFIAELIDVLLVNLIPNWK 420          

Query:   67 NEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQP-TARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNG--SPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLT-DHDVAFIAEFIDYLIMKLLPGW 1317
            N E ++VE DP+ RY RY E+LGKGAFK VY+AFD+++GIEVAWNQVK+D    S EDL++LYSEVHLLK+L H++IIKFY SW+D+   TIN+ITE+FTSG+LRQYRKK+K VD +A++ W+RQIL GLV+LHSH+PP+IHRDLKCDNIFINGN GEVKIGDLGLA ++ +  +A SVIGTPEFMAPELYEE+YN LVDIY+FGMC+LE+VTFEYPYSEC + AQI++KVTSGIKPA+L  V D Q++ FIEKC+ + S+RLSAKELL DPFL+                                     YK+ + +  +   NG     +++    ++     + G + D +++ L LRI  + G++RNIHF F + TDT+ SV  EMVE+L LT D D++ IA+ ID  I   +P W
Sbjct:    7 NSEEEFVEIDPTGRYGRYKEVLGKGAFKEVYRAFDQLEGIEVAWNQVKLDDKFCSSEDLDRLYSEVHLLKTLKHKSIIKFYTSWIDHQHMTINLITEVFTSGNLRQYRKKHKCVDLRALKKWSRQILEGLVYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILHRARSAHSVIGTPEFMAPELYEEDYNVLVDIYAFGMCLLELVTFEYPYSECTNAAQIYRKVTSGIKPAALLNVTDPQVRAFIEKCIAKVSQRLSAKELLDDPFLKC------------------------------------YKENTENVSSHKENGYNGNGIVDKLSDSEVGLLTVEGQRKDLNTIFLKLRITDSKGQIRNIHFPFNIETDTSFSVAIEMVEELDLTDDQDISTIAKMIDTEIHSHIPDW 391          

Query:   46 LSKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDN--------PMEPIRDPL-QLPNQSLKVINLP-KSGPLSMDIDT-DYKQLSISTCAGSNNGSPQVLEFQ------------------------------RTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            LS ++P  + +++VE DP+ RY RYNE+LGKGA KTVY+AFDE +GIEVAWNQVK+   L+SPEDLE+LY E+HLLK+L H+NI+KFY SWVD     IN +TELFTSG+LRQYR ++K V+ +A+++W RQILRGL +LHSH+PP+IHRDLKCDNIF+NGN GEVKIGDLGLA ++++  A   +GTPEFMAPE+YEE YNELVDIYSFGMC+LEMVTF+YPYSEC  PAQI+KKV SG KP +L KV D ++K FIEKCL   S R+SA+ELL DPFL++D+         ME    PL + P+      N P  S  L+      +Y   S S     +NG     E+Q                              + + N    + G + DD  + L LRIA   G+VRNI+F F + TDTA+SV +EMV +L + DH V  IA  ID  I  L+P W+
Sbjct:    4 LSYLEP--DYSEFVEVDPTGRYGRYNEVLGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTELFTSGTLRQYRLRHKRVNIRAMKHWCRQILRGLHYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFDYPYSECTHPAQIYKKVMSGKKPDALYKVKDPEVKCFIEKCLATVSLRVSARELLDDPFLRIDDGEFDLRSVDMEDSVGPLYRQPHHLPDYYNYPSNSSSLNRQYSNGNYPSNSSSLNRQYSNGYNSHHEYQNGWAYNPAETEETHGIELFESRNNDDQEEEKKSGNVDITIKGKRRDDGGLFLRLRIADKEGRVRNIYFPFDIETDTALSVATEMVAELDMDDHGVTKIANMIDGEISSLVPSWR 467          

Query:   82 YVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQ----FRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            +VE DPS RY RY+EILGKGA KTVY+AFDE +GIEVAWNQVK+    R+PE+LEK + E+HLLK+LNH+NI+KFY SWVD +  +IN +TELFTSG+LRQYR +++ V+ +A++ W +QIL+GL++LHS +PPIIHRDLKCDNIFINGN GEVKIGDLGLA ++++  A   +GTPEFMAPE+Y+EEYNELVD+Y+FGMC+LEMVTF+YPYSEC  PAQI+KKVTSG KP +   V D +++EF+EKCL   + RL+A ELL+DPFLQ DN    +  P+   N       +    PL +D    + Q            S Q+ E      +++      + G +N DD + L LRI+ A G++RNI+F F  A DTA SV  EMV +L +T+ DVA IAE ID  I  L+P WK
Sbjct:   14 FVEIDPSGRYGRYDEILGKGASKTVYRAFDEYEGIEVAWNQVKLRNFTRNPEELEKFFREIHLLKTLNHQNIMKFYTSWVDTNNLSINFVTELFTSGTLRQYRLRHRRVNIRAVKQWCKQILKGLLYLHSRSPPIIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAVRCVGTPEFMAPEVYDEEYNELVDVYAFGMCVLEMVTFDYPYSECTHPAQIYKKVTSGKKPEAFYLVKDPEVREFVEKCLANVTCRLTALELLQDPFLQDDNMDGFVMRPIDYYN-GYDETGVFLRHPL-IDDPLYHDQFE----------SSQICEIDLFANDDEDHVDISIKGKRNGDDGIFLRLRISDAEGRIRNIYFPFETAIDTAWSVAVEMVSELDITNQDVAKIAEMIDAEIAALVPDWK 418          

Query:   67 NEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFL---------------QVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDD-DSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGW 1317
            ++ ++YVE DP+ RY RYNE+LGKG+ KTVY+ FDE  GIEVAWNQVK+   L+SP++LE+LY E+HLLK+L H++I+KFY SWVD     IN +TE+FTSG+LRQYR K+K V+ +A++NW RQILRGL +LH+H+PP+IHRDLKCDNIFINGN GEVKIGDLGLA  +Q   A   +GTPEFMAPE+Y+EEYN+LVDIYSFGMC+LEMVTF+YPYSEC  PAQI+K+V SG KP  L KV D +++ FIEKCL   S RLSA ELL D FL                +D    P+R    +P+ S    +L        + D   +   I      N+   +  E  +   +    + G + D+ D + L L+     G VRNI+F F + TDTA+SV  EMVE+L++ D DV  IA  ID  I  L+P W
Sbjct:   10 SDYSEYVEVDPTGRYGRYNEVLGKGSSKTVYRGFDEYQGIEVAWNQVKLYDFLQSPQELERLYCEIHLLKTLKHKSIMKFYASWVDTDNRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKNWCRQILRGLNYLHTHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAACLQHSHAAHCVGTPEFMAPEVYKEEYNQLVDIYSFGMCVLEMVTFDYPYSECSHPAQIYKRVISGKKPDGLDKVKDPEVRGFIEKCLATVSLRLSACELLDDHFLCIDESDMRRVESEKGLIDEAGTPLRHSYHIPHYSNGYYSLYNQNQWDYNGDETVESHEIDLLEFQNDDDEE--EEDKRFGSVDISIKGKRRDNGDGLFLRLKTVNKEGCVRNIYFPFDIETDTAISVAREMVEELEMDDRDVTKIANMIDGEIASLVPNW 440          

Query:   55 VKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNP-MEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSS-------LWGSALSGVPASSGVEQD---------------GSCCDNPETVNCNGGITSYPSFADFADEHSKVSVESAVLVDDASTKNDKVAESVDCSNTDGSCMCSFFY--DIKFQSNYA--------SNAEECSLVNGITD--KLVFPLLEIEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKKKVPVH 1947
            ++P +  AD VE+DP+ RYVRY+++LGKGAFKTVY+AFDEVDGIEVAWNQV+ID VLRSPED EKLYSEV+LL+SL HENIIKF NSWVD+   TINMITELFTSG+LRQYR+K++N+D KAI+NWARQILRGLV+LH H+PPIIHRDLKCDNIF+NGNHGEVKIGDLGLA VMQ PTA+SVIGTPEFMAPELYEEEYNELVDIYSFGMC+LE+VT  YPYSEC++ AQI+KKVTSGIKPASL  V + QIKEFIEKCL+ ASERLSAKELLK PFLQ++ P +E I DPL +P+Q    ++LPKSGPL MD+D D KQLS STC GSNNGSP+  VLE+QR +KNN+F L GMKNDD+S SLTLRI+   G+VRNIHF FYL +DTA+SV SEMVEQL+L DHDVAFIAE ID LI+KLLPGWK                     +        W S LS VP  +  EQD                +  D+P          S PS A+  D+ S+ S+ S +LV  AS+ N + +E     N DGS   +  Y  + K    Y         S   E   +N  T+  +  FP  +  A  VM           AD D   +LK  LD IE+QY  WF EL+RM+E+ALE TRKRW EKKK+  H
Sbjct:    1 MEPSDAGADLVEKDPTGRYVRYDDVLGKGAFKTVYRAFDEVDGIEVAWNQVRIDDVLRSPEDFEKLYSEVYLLRSLRHENIIKFSNSWVDDKNKTINMITELFTSGNLRQYRRKHRNIDIKAIKNWARQILRGLVYLHGHSPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQNPTAKSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCNYPYSECRNAAQIYKKVTSGIKPASLKTVGNTQIKEFIEKCLLPASERLSAKELLKHPFLQLEIPILEQICDPLPVPDQFPISLSLPKSGPLFMDMDIDEKQLSESTCTGSNNGSPKSPVLEYQRAHKNNEFGLKGMKNDDNSASLTLRISDLGGRVRNIHFIFYLDSDTAISVASEMVEQLELADHDVAFIAELIDSLIVKLLPGWKPSSYGSSNVAIGPCTESPVFENGEKSIAYPWNSMLSSVPVGTLAEQDDLSGLTRSHCLQADDSNISDSPNNEISQFVYNSSPSLANMGDQESQSSIVSEILVQGASSINSRTSEYY---NNDGSFKGTNGYVTESKLGDAYLNCKLDRQDSYVGEFVSMNESTENSEWSFPK-QSGASNVMSLTSSCSSQSLADKDGYDDLKLGLDAIEAQYHNWFVELTRMKEEALEATRKRWTEKKKLAAH 664          

Query:   79 DYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSLWGSALSGVPASSGVEQDGSCCDN---PETVNCNGGITSYPSFADFADEHSKVSVESAVLVDDASTKNDKVAESVDCSNTDGSCMCSFFYDIKFQSNYASNAEECSLVNGITDKLVFPLLEIEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEK 1929
            ++ E+DP+ RYVRY+EILGKGAFKTVYKAFDEVDGIEVAWNQV I+ VL+S + LE+LYSEVHLLKSL HENIIKFYNSWVD+   TINMITEL TSG+LRQYRKK+K VD KAI+NWARQILRGL +LH+ +P IIHRDLKCDNI +NGN+GEVKIGDLGLA VMQQP ARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVT EYPYSECK+PAQI+KKVTSGIKPASLGKVNDLQ+KEFIEKCLV AS RLSA +LLKDPFL  +N  E +    QLPN   K ++LP+S    MDID   K LS+ +C  S N SP+   LE +R  +NN+FRL   KNDD++VSLTLRIA  CG+ RNIHF FYL +DTAVS+  EMVEQL L+  DVA IAE ID LI+KL+P W                                  SS V    S  +N    ETV        +    +  D  +  SV S    D ++  N  +A     + + GS  CS       QSN   + + CS+++      +   L +                 AD D  +ELK ELD+I+S Y + F+EL + RE+A+E  ++RWI K
Sbjct:   13 EFAEKDPTGRYVRYDEILGKGAFKTVYKAFDEVDGIEVAWNQVDIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYNSWVDDKNKTINMITELLTSGNLRQYRKKHKTVDMKAIKNWARQILRGLQYLHTRSPRIIHRDLKCDNILVNGNNGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVTSGIKPASLGKVNDLQVKEFIEKCLVPASVRLSAIDLLKDPFLATENSKEVVSSLSQLPNVICKQVHLPQSESHHMDIDC--KMLSLGSCPKSINESPRFLTLELRRFTENNEFRLRAEKNDDNTVSLTLRIADPCGRARNIHFTFYLNSDTAVSIAEEMVEQLDLSSEDVAVIAELIDSLIVKLVPCWN--------------------------------TSSSVRNGSSELENHATSETVK----TPDFSPLTNITDHEALQSVNS----DISAEYNMAIASDASTNKSLGSSSCS------LQSN-VFHIDSCSVMSRNASLSIICSLFL-----------------ADKD-GSELKLELDSIDSHYNQCFQELMKTREEAIENAKRRWISK 567          

Query:   82 YVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSLWGSALSGVPASSGVEQDGSCCDNPETVNCNGGITSYPSF---ADFADEHSKVSVESAVLVDDASTKNDKVAESVDCSNTDGS---CMCSFFYDIKFQSNYASNAEECSLVNGITDKLVFPLLEIEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKK 1932
            + E+DP+ RY+R +E LGKGAFKTVYKAFDEVDGIEVAWNQV I+ VL+S + LE+LYSEVHLLKSL HENIIKFY+SWVD+   TIN+ITELFTSGS+RQYRKK+K VD KAI+NWARQILRGL +LH+H+PPIIHRDLKCDNIF+NGN GEVKIGDLGLA VMQQP ARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVT EYPYSECK+PAQI+KKV+SGIKPASLGKV+D Q+K FIEKCLV AS RL A ELLKDPFL  +N  E +   LQLPN   + ++L +S    MDID   K+LS+ +C  S N SPQ   LE  R  +NN+FRL G KN+D++VSLTLRIA  CG+ RNIHF FYL +DTAV +  EMVEQL L   DVA IAE ID LI KL+P W                                  S  V    S  +N  T          P F    +  D  +K SV S    D ++  N  +A     + + GS   C+ S  YD++F       ++         D  +     +     M           AD D  +ELK ELD+I+S Y +  +EL +MRE+A+E  +KR I KK
Sbjct:   14 FAEKDPTGRYIRNDEFLGKGAFKTVYKAFDEVDGIEVAWNQVNIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYSSWVDDKNKTINIITELFTSGSMRQYRKKHKTVDMKAIKNWARQILRGLHYLHTHSPPIIHRDLKCDNIFVNGNTGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVSSGIKPASLGKVSDHQVKVFIEKCLVPASTRLPAIELLKDPFLATENSKELVSSSLQLPNLISRQVHLLQSESHLMDIDC--KKLSVGSCTKSINESPQFSTLELSRFTENNEFRLRGAKNNDNTVSLTLRIADPCGRARNIHFTFYLDSDTAVLIAEEMVEQLDLLTEDVAVIAELIDNLIAKLVPSWN--------------------------------TSPSVRNGSSELENHSTSEA----VKKPDFLPLTNMTDLETKQSVNS----DISAEYNMAIASDSGTNKSLGSSDCCLQSNMYDLEFGMLEDGISKHNKSTRNSNDSYIGSFSGMSRNASM---SSICSLSLADKD-GSELKQELDSIDSHYNQCLQELMKMREEAIENAKKRGITKK 592          

Query:   49 SKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVD----NPMEPIRDPLQLPNQSLKVINLPKSGPL-------SMDIDTDYKQLSISTCAGS--NNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACG-KVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            S  +PP  + D +E DP+ RY+RY E+LGKGAFKTVYKAFDEV+GIEVAWNQV+ID VL+SP+DLE+LYSE+HLLK+L + NI++FYNSW+D+ K T+N+ITELFTSGSLRQY KK++ ++ KA++ WARQIL GL +LH+H+PPIIHRDLKCDNIFINGN GEVKIGDLGLATVM+Q  A+SVIGTPEFMAPELY+E YNEL DIYSFGMCMLEMVTFEYPYSEC++ AQI+KKV+SGIKPASL KV D  +K+FIEKCL+ ASERL AKELL DPFL V+    N      D L     ++    L   GP        SMD+  D +  +I++   S   +     LE +R  + N F L G  ND++SVSL LR+A   G +VRNIHF FYL  DTA+SV+SEMVEQL+L   +V FIAE ID L++KL+P WK
Sbjct:    9 SHSEPP--DPDVLEIDPTCRYIRYKEVLGKGAFKTVYKAFDEVNGIEVAWNQVRIDEVLQSPDDLERLYSEMHLLKTLKNSNIVRFYNSWIDDKKKTVNIITELFTSGSLRQYCKKHRKIEMKAVKGWARQILNGLNYLHNHDPPIIHRDLKCDNIFINGNQGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFEYPYSECRNSAQIYKKVSSGIKPASLSKVKDPDLKQFIEKCLLPASERLPAKELLMDPFLDVNGFARNSSMSRSDILMSKMTAIGDRCLMSEGPATARNKPPSMDLSHDPEMPTITSFNNSVDEDTHSLCLEVRRAKRGNVFLLRGEGNDENSVSLILRMADQNGARVRNIHFLFYLDGDTALSVSSEMVEQLELEVENVKFIAELIDLLLLKLIPNWK 444          

Query:   82 YVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSL--KVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIA-YACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            +VE+DP+ RYVRY+EILG G  KTVY+AFDEVDG+EVAW Q  ++ V  S + LE+  SE  LLKSL ++NIIKFY+ W+D+ K T+NMITE+F SGSL QY KK+K+VDTKAI+NWARQILRGL +LH+H PPII  +LKCD+IF+NGN+GEVKIGDLGLA V QQPT  S +GTP +MAPEL E+EYNELVD+YSFGMCMLEMVT EYPY E K+P Q++KKV SG+KPASL KVND Q+K+FIEKCLV AS RL A ELLKDPFL  +N  + +   ++LPN  +  +VINLP S   SMDID   K+L + +C  S +   Q   LE  +  + N+FRL G K D +++SL L I   +C   R + F F+L +DTAVSV  EMVEQL L+  D A+ AE ID L+MKL+P WK
Sbjct:    8 FVEKDPTGRYVRYDEILGGGTVKTVYRAFDEVDGVEVAWKQANVEDV--SQKQLERWTSEARLLKSLKNKNIIKFYDFWIDDEKKTLNMITEIFVSGSLSQYCKKHKDVDTKAIKNWARQILRGLHYLHNHEPPIILGNLKCDSIFVNGNNGEVKIGDLGLAIVTQQPTGSSDLGTPAYMAPELCEDEYNELVDVYSFGMCMLEMVTCEYPYCEIKNPGQVYKKVISGVKPASLNKVNDPQVKQFIEKCLVPASLRLPAIELLKDPFLATENSKDTVSGSMKLPNNLMPKQVINLPHSESRSMDIDD--KKLLVGSCKESIDEKLQFSTLEICKFTEKNEFRLRGEKIDSNTISLNLNITETSCSLERKVEFPFHLDSDTAVSVAEEMVEQLGLSPEDAAYNAELIDILVMKLVPSWK 421          

Query:   49 SKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQP-TARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGW 1317
            S+  P + +A++VE DP+ RY RY E+LG+GAFK VY+AFDE +GIEVAWNQVK+  +LR+  DLE+LYSEVHLL +L H+NIIKFYNSW+D     IN ITE+FTSG+LRQYR+K+K+V  +A++ W+RQIL GL++LHSH+PP+IHRDLKCDNIF+NGN GEVKIGDLGLA ++QQ  +A SVIGTPEFMAPELYEEEYNELVDIY+FGMC+LE+VT EYPY EC + AQI+KKVTSGIKPASL KV D  +K FIEKC  + S+RL AKELL DPFLQ D   E +    +           PK+       D    Q+ ++  A  ++  P             F + G + D +++ L LRIA + G +RNIHF F +  DTA++V SEMVE+L LTD DV+ IA  ID  I   +PGW
Sbjct:    7 SETDPDDSDAEFVEIDPTGRYGRYKEVLGRGAFKKVYRAFDEFEGIEVAWNQVKVADLLRNSVDLERLYSEVHLLNTLKHKNIIKFYNSWIDTKNENINFITEIFTSGTLRQYRQKHKHVGLRALKKWSRQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILQQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCLLELVTVEYPYVECTNAAQIYKKVTSGIKPASLAKVKDPAVKAFIEKCTAKVSDRLPAKELLMDPFLQSDEENESVGHSFR-----------PKAHSSGGSSD----QIDVNEIAKDSSAEP----------IRDFTVQGQRKDINTIFLKLRIADSTGHIRNIHFPFDVEVDTAIAVASEMVEELDLTDQDVSTIAAMIDSEIRSHIPGW 405          

Query:   49 SKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQP-TARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGW 1317
            S+  P + +A++VE DPS RY RY E+LG+GAFK VY+AFDE++GIEVAWNQVK+  +LR+  DLE+L+SEVHLLK+L H+NIIKFYNSWVD     IN ITE+FTSG+LR+YR+K+K+VD +A++ W++QIL GL++LHSH+PP+IHRDLKCDNIF+NGN GEVKIGDLGLA ++QQ  +A SVIGTPEFMAPELYEEEYNELVDIY+FGMC+LE+VT EYPY EC + AQI+KKVTSGIKPASL KV D  +K FIEKC+ + S+RL AKELL DPFL+ D   E +     L  ++        SG +S  +D +       + A S               +  F + G + D +++ L LRIA + G  RNIHF F +  DTA++V SEMVE+L +TD DV+ IA  ID  I   +P W
Sbjct:    7 SEPDPDDSDAEFVEIDPSGRYGRYKEVLGRGAFKKVYRAFDELEGIEVAWNQVKVADLLRNSVDLERLFSEVHLLKTLKHKNIIKFYNSWVDTKNENINFITEIFTSGTLRKYRQKHKHVDLRALKKWSKQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILQQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCLLELVTVEYPYVECSNAAQIYKKVTSGIKPASLAKVKDPAVKAFIEKCIAKVSDRLPAKELLMDPFLRSDE--ENVSGGCSLRPKA------HSSGGISDQLDVNESAKDKDSAAES---------------SRDFSVQGQRKDINTIFLKLRIADSTGHFRNIHFPFDVKVDTAIAVASEMVEELDVTDQDVSTIAAMIDSEIRSHIPDW 407          

Query:   79 DYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDN---PMEPI--------------RDPLQLPNQSLKVINLPKSGPLSMDIDT--DYKQLSISTCAGSNNGSPQVL---EFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            ++VE DP+ RY RYNEILGKGA KTVYKAFDE +GIEVAWNQVK+   L++ EDLE+LY E+HLLK+LNHENI+KFY SWVD     IN +TE+FTSG+LRQYR K++ V+ +A+++W RQIL GL++LHSH+PP+IHRDLKCDNIF+NGN GE+KIGDLGLA ++++  A   +GTPEFMAPE+YEEEYNELVDIYSFGMC+LEMVTFEYPYSEC   AQI+KKVTSG KP +L KV D ++++F+EKCL   S RLSA+ELL DPFLQ+D+    ++PI              R PL   ++S   +    +  +  D++   +Y QL + T       SP  L   +     +N    + G + +DDS+ L LRIA   G++RNI+F F + TDTA+SV +EM+++L +T+ DV  +A+ ID  I  L+P WK
Sbjct:   13 EFVEVDPTGRYGRYNEILGKGASKTVYKAFDEYEGIEVAWNQVKLYDSLQTSEDLERLYCEIHLLKTLNHENIMKFYTSWVDTSNRNINFVTEMFTSGTLRQYRLKHRRVNIRAVKHWCRQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEIKIGDLGLAAILKKSHAARCVGTPEFMAPEVYEEEYNELVDIYSFGMCVLEMVTFEYPYSECNHAAQIYKKVTSGKKPDALYKVKDPELQKFVEKCLATVSTRLSARELLNDPFLQIDDSGCDLKPIDYYQGDLNGVGPLVRQPLHGIHRSNSSLTDGYTNYMGYDLENEIEYHQLELET-------SPIDLFTCQEDENLENVAIAIKGRRIEDDSIFLRLRIADKEGRIRNIYFSFDIETDTAISVATEMIDELDITEQDVLKVAKMIDDEISTLVPEWK 441          

Query:   82 YVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAP-ELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIA-YACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            ++E+DP+ R+VR +EILG G  KT Y+AFDEVDG+EVAW QV ++ V  SP+ LE+L +E  LLKSL  +NIIK Y+ W+D+ K T+NMITE+F SGSL QY KK+K V+ KA++NWARQILRGL +LH+H PPIIH DL+CDNIF+NGN+GEVKIGDLGLA VMQ+PT    +GTP +MAP +L EEEYNELVD+YSFGMCMLEMVT EYP  ECK+P QI+KKV SG+KPASL KVND Q+K+FIEKCLV AS RLSA ELLKDPFL  +N  + +   ++LPN       +PK            K+L + +C  S N   Q    E  + N+ N+FRL G K D++++SLTL I   +C + R + F FYL +DTAVSV  EMVEQL+L+  D A  A+ ID L+MKL+P  K
Sbjct:    6 FLEKDPTGRFVRSDEILGGGVVKTAYRAFDEVDGVEVAWKQVNVEHV--SPKQLERLTTEARLLKSLKDKNIIKIYDFWIDDEKKTLNMITEIFVSGSLSQYCKKHKGVNAKAVKNWARQILRGLHYLHTHEPPIIHGDLRCDNIFVNGNNGEVKIGDLGLAIVMQRPTGLCDLGTPAYMAPDQLCEEEYNELVDVYSFGMCMLEMVTREYPCCECKNPGQIYKKVISGVKPASLDKVNDPQVKQFIEKCLVPASLRLSAIELLKDPFLATENSKDTVSSSMKLPNNL-----MPKQ-----------KKLLVGSCKESINEQLQFSTPEICKVNEKNEFRLRGEKIDNNTISLTLNITETSCCQSREVEFSFYLDSDTAVSVAEEMVEQLELSPEDAACSAKLIDALVMKLVPSLK 404          

Query:   46 LSKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNG-------------------SPQVLEFQRTNKNN-QFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            LS ++PP + +++VE DP+ RY RYNEILG+GA K VY+AFDE +GIEVAWNQVK+   L+SPEDLE+LY E+HLLK+L H+NI+KFY SWVD     IN +TE+FTSG+LRQYR K+K V+ +A+++W RQILRGL++LHSH+PP+IHRDLKCDNIF+NGN GEVKIGDLGLA ++++  A   +GTPEFMAPE+YEE YNELVDIYSFGMC+LEMVTFEYPYSEC  P QI+KKV SG KP +L KV D +++ F+EKCL   S RLSA+ELL DPFLQ+D         L+L +  ++V  L   GPL      ++   + S  +G  NG                     ++ E+   +  N    + G + DD  + L LRIA   G++RNI+F F +  DTA+SV +EMV +L +TD DV  IA+ ID  I  L+P W+
Sbjct:    4 LSHLEPP-DYSEFVEVDPTGRYGRYNEILGRGASKIVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPVQIYKKVISGKKPDALYKVKDPEVRHFVEKCLATVSLRLSARELLNDPFLQIDG----CESDLRLLDHRIEVDGL---GPLMRPPYLEHHDNNNSYSSGYLNGYDYEAQNEWEYHQVEVELSGIELFEYHDEHPANVDISIKGKRGDDGGIFLRLRIADKEGRIRNIYFPFDIENDTALSVATEMVAELDITDQDVTKIADMIDGEIASLVPEWR 440          

Query:    1 MDTGVGLVPPSSNGMLSKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVY---------KAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK-------XXXXXXXXXXXXXXXXXXXMSSLWGSALSGVPASSGVEQDGSCCDNP-----ETVNCNGGITSYPSFADFADEHSKVSVESAVLVDDASTKNDKVAESVDCSNTD 1620
            M++GV LV P+SNG L  VK P+EEAD++E+DPSNRYVRYNEILGKGAFKTVY         KAFDEVDGIEVAWNQVKID VLRSPEDLEKLYSEVHLLKS+ H+NIIKFYNSWVD+ KNTINMITELFTSGSLR+YRKK+KNVD KAIRNWARQIL GLVFLHSHNPPIIHRDLKCDNIFINGN GEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVD+YSFGMCMLEMVTFEYPY ECKSPAQIFKKVTSG+KPA+LGK           KCLV ASERLSAKELLKD FLQVDNP EPIRDP QLPNQSLK  NLPKSGPLSMDIDTDYKQLSISTCA SNNGSPQVLEFQR +KNN+FRLSG+KNDDDSVSLTLRIA ACGK RNIHF FY+A+DTAVSV SEMVEQL+LT+HDVAFIAEFIDYLIMKLLPGWK                          +SSLWGS LSG PA S VEQDGS CD P     +T+N NGGITSYPSFADFA EHSKVSV S V+VDD STKND+  ESV+C+ ++
Sbjct:    1 MNSGVRLVSPASNGKLPVVKLPDEEADFIEKDPSNRYVRYNEILGKGAFKTVYGSETFSLHYKAFDEVDGIEVAWNQVKIDAVLRSPEDLEKLYSEVHLLKSVKHDNIIKFYNSWVDDQKNTINMITELFTSGSLRRYRKKHKNVDMKAIRNWARQILGGLVFLHSHNPPIIHRDLKCDNIFINGNLGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDVYSFGMCMLEMVTFEYPYCECKSPAQIFKKVTSGVKPAALGK-----------KCLVPASERLSAKELLKDAFLQVDNPKEPIRDPFQLPNQSLKATNLPKSGPLSMDIDTDYKQLSISTCAESNNGSPQVLEFQRAHKNNEFRLSGIKNDDDSVSLTLRIADACGKARNIHFLFYIASDTAVSVASEMVEQLELTNHDVAFIAEFIDYLIMKLLPGWKPSIDYSSSGPTSLCGGSPVYRNGKPSLSSLWGSVLSGAPAGSMVEQDGSSCDKPDKILNDTINFNGGITSYPSFADFAVEHSKVSVHSEVMVDDGSTKNDQAVESVNCNTSE 550          

Query:  121 NEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELL----KDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK-------XXXXXXXXXXXXXXXXXXXMSSLWGSALSGVPASSGVEQDGSCCDNPETVNCNGGITSYPSFADFADEHSKVSVESAVLVDDASTKNDKVAESVDCSNTDGSCMCSFFYDIKFQSNYASNAEECSLVNGITDKLVFPLLEIEAPKVMXXXXXXXXXXXADN---DLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKKKVPV 1944
            NE  G+    + YKAFDEVDGIEVAW++VK+D VLRSPEDLEKLY                                            RKK+KNVDTKAIRNWARQILRGL FLHSH+PPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEM+TFEYPYSECKSPAQIF KVTS         V++   +     C +   E LS+  +L    +D FLQVDNP EPIRDPLQLPNQSLK  NLPKSGPLSMDIDTDYKQLSISTC GSNNGSPQVLEFQRT+KNN+FRLSG+KNDDDSVSLTLRIA ACGKVRNIHF FY+A+DTA SV  EMVEQL+L DHDVAFIAEFIDYLI KLLPGWK                          +SSLWGS L G P    VEQDGS CDNP+T+N NGGITSY SFAD                           ESV+C+ ++     S+F D K QSNYASN      VNGI  KL FPL   +  K M            D+   +LDA+ K EL+ IESQYQRWF+ELSRMREKALE+TRKRWIEKKKV V
Sbjct:   57 NEFRGRIGIASNYKAFDEVDGIEVAWSRVKVDAVLRSPEDLEKLY--------------------------------------------RKKHKNVDTKAIRNWARQILRGLAFLHSHSPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMITFEYPYSECKSPAQIFTKVTS---------VSEESSEYHHSFCWLFKVESLSSTGILFLHPRDAFLQVDNPKEPIRDPLQLPNQSLKATNLPKSGPLSMDIDTDYKQLSISTCTGSNNGSPQVLEFQRTHKNNEFRLSGIKNDDDSVSLTLRIADACGKVRNIHFLFYIASDTAASVAREMVEQLELADHDVAFIAEFIDYLIRKLLPGWKPSSDYSSSGPASLCGGSLVRKNGKPSLSSLWGSVLFGAPDGLMVEQDGSSCDNPDTINFNGGITSYQSFAD---------------------------ESVNCNTSELEPRYSYFDDRKLQSNYASNEGGGFPVNGIIKKLQFPLHGHDLSKDMSLTSSCYSPSLVDSKDMNLDADSKLELEMIESQYQRWFQELSRMREKALEMTRKRWIEKKKVAV 598          

Query:  157 YKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNN--GSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSLWGSALSGVPASSGVE--QDGSCCDNPETVNCNGGITSYPSFADFADEHSKVSVESAVLVDD------ASTKNDKVAESVDCSNTDGSCMCSFFYDIKFQSNYASNAEECSLVNGITDKLVF------PLLEIEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKKKVPVH 1947
            YKAFDE +GIEVAW QV I+ VL+SPE LE+LYSEVHLLKSL H+NI+KF+NSWVD+   TIN+ITELFTSGSLRQYRKK+KNVD KAI+NWARQILRGL +LHSHNPPIIHRDLKCDNIF+NGN GE+KIGDLGLA VMQQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMCMLEMVT EYPYSECK+PAQI+KKVTSG+KPASL KV++ QIKEFIEKCLV AS RLSA ELLKDPFL  DN    +++P  +P+Q  K++NLP+     MD+DT+Y++ S   C  S N   +P VLE Q   +NN+FRL   KN D +VSLTLRIA  CG+VRNIHF FYL +DTA+S+  EMVEQL L   DV+ IAE ID LIMKL+PGWK                               P+S G     + SC D+    N    + S+ + A+  D  S +  +++V   +      +   N KV ES   S +D  C        K    YAS+ +   +V G+  +  +        +  EA   M           A+ D   ELK ELD I+  Y+R   EL R RE+ +   +KRWIEKKK+ V+
Sbjct:  579 YKAFDEEEGIEVAWCQVNIEEVLQSPEQLERLYSEVHLLKSLKHQNIVKFHNSWVDDKNKTINIITELFTSGSLRQYRKKHKNVDMKAIKNWARQILRGLHYLHSHNPPIIHRDLKCDNIFVNGNTGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVTSGVKPASLSKVDNPQIKEFIEKCLVPASMRLSAVELLKDPFLATDN----LKEPNCIPSQLEKLVNLPQPEACPMDVDTNYQKSSSGFCRRSTNEISNPSVLELQSFTENNEFRLKAEKNSDRTVSLTLRIADTCGRVRNIHFEFYLDSDTAISIAGEMVEQLDLPHEDVSVIAELIDNLIMKLVPGWK-------------------------------PSSEGSSCGTNSSCVDHAALQN----VLSHVAHAEDRDNQSSMISDTSVTSAEHGVPTASGASNVKVMESAKYS-SDECC--------KASDGYASSPD--CMVKGVVKEKSYEADSGDSFVMNEACTDMSSICSLSELSLANKDGYGELKGELDAIDMHYRRCLVELLRSREEEIRSAKKRWIEKKKIAVN 1141          

Query:   70 EEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            E+A  VE+DP+ RY+RY+E+LG+GAFKTVYKAFDEV+G+EVAW QV I  V    E++E+LYSEVHLLKSL H+NI++F+NSWVD+   TINMITELFTSGSLRQYR K+K VD KAI+NWARQILRGL +LHSHNPPIIHRDLKCDN+F+NG +GE+KIGDLGLA VMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMCMLEMVT EYPYSECK+ AQI+K+VTSG+KPASL KV++ QIK+FIEKCLV AS RLSA ELLKDP L  DN  E   D  QL     K+  LP+                      ++N S  VLE    +KNN+FRL   KN D++VSLTLRIA  CG VRNI F FYL +DT +S+  EMVEQL L+  DV+ +AE  D  I+KL+PGWK
Sbjct:    8 EDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNLAQIYKRVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQ----KLFTLPEP---------------------TSNSS--VLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWK 393          

Query:   70 EEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            E+A  VE+DP+ RY+RY+E+LG+GAFKTVYKAFDEV+G+EVAW QV I  V    E++E+LYSEVHLLKSL H+NI++F+NSWVD+   TINMITELFTSGSLRQYR K+K VD KAI+NWARQILRGL +LHSHNPPIIHRDLKCDN+F+NG +GE+KIGDLGLA VMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMCMLEMV  EYPYSECK+ AQI+K VTSG+KPASL KV++ QIK+FIEKCLV AS RLSA ELLKDP L  DN  E   D  QL     K+  LP+                      ++N S  VLE    +KNN+FRL   KN D++VSLTLRIA  CG VRNI F FYL +DT +S+  EMVEQL L+  DV+ +AE  D  I+KL+PGWK
Sbjct:   42 EDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAXVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQ----KLFTLPEP---------------------TSNSS--VLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWK 427          

Query:   70 EEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            E+A  VE+DP+ RY+RY+E+LG+GAFKTVYKAFDEV+G+EVAW QV I  V    E++E+LYSEVHLLKSL H+NI++F+NSWVD+   TINMITELFTSGSLRQYR K+K VD KAI+NWARQILRGL +LHSHNPPIIHRDLKCDN+F+NG +GE+KIGDLGLA VMQQPTA S+IGTPEFMAPELY+EEYNELVDIYSFGMCMLEMV  EYPYSECK+ AQI+K VTSG+KPASL KV++ QIK+FIEKCLV AS RLSA ELLKDP L  DN  E   D  QL     K+  LP+                      ++N S  VLE    +KNN+FRL   KN D++VSLTLRIA  CG VRNI F FYL +DT +S+  EMVEQL L+  DV+ +AE  D  I+KL+PGWK
Sbjct:    8 EDAGVVEKDPTGRYLRYDEVLGRGAFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAXVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQLQ----KLFTLPEP---------------------TSNSS--VLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWK 393          

Query:   49 SKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQP-TARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGW 1317
            S+    + + ++VE DP+ RY RY E+LGKGAFK VY+AFDE++G+EVAWNQVK+  +LR+ EDL +LYSEVHLLK+L H+NIIKFYNSWVD     IN+ITE+FTSG+LRQYR+K+K+VD +A++ W+RQIL GL +LH+H+PP+IHRDLKCDNIF+NGN GEVKIGDLGLA +++Q  +A SVIGTPEF APELYEEEYNELVDIY+FGMC+LE+VTFEYPY EC + AQIFKKVTSG+KPASL KV D  +K FIEKC+V+ SERL AKELL DPFLQ D+  E I       ++SL+  +   +   S   D + K    S                    +  F + G +  DD++ L LRIA + G  RNIHF F +  DTA++V SEMV++L LTD DV+ +AE ID  I   +P W
Sbjct:    7 SEXDTDDADTEFVEVDPTGRYGRYKEVLGKGAFKKVYRAFDELEGLEVAWNQVKVADLLRNSEDLVRLYSEVHLLKTLKHKNIIKFYNSWVDAKHENINIITEIFTSGTLRQYRRKHKHVDLRALKKWSRQILEGLWYLHNHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQARSAHSVIGTPEFXAPELYEEEYNELVDIYAFGMCLLELVTFEYPYVECSNAAQIFKKVTSGVKPASLXKVTDPGVKAFIEKCIVKVSERLPAKELLMDPFLQSDDNRESI-------SRSLRPTHYSDAEGSSDQTDIETKDTDPS-----------------HETSRDFSVQGQRK-DDTIFLKLRIADSTGHFRNIHFPFDIGEDTAIAVASEMVQELDLTDQDVSTLAEIIDSEIHSHIPDW 405          

Query:   70 EEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKV-------TSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDN------PMEPIRDP------LQLPNQSLKVINLPKSG------PLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGW 1317
            E +++VE DP+ RY RYNE+LGKGA KTVY+AFDE +GIEVAWNQVK+   LR+PEDLE+LY E+HLLK+L H NI+KFY SWVD     IN +TE+FTSG+LRQYR K+K V+ +A+++W RQIL+GL++LHSH+PP+IHRDLKCDNIFINGN GEVKIGDLGLA V+++  A   +GTPEFMAPE+YEEEYNELVDIYSFGMC+LEMVTFEYPYSEC +PAQI+KKV       + G KP +L KV D +++ F+EKCLV  S RLSA+ELL+DPFLQVD+      P E  RD       L+ P+ SL   N   S           + D DY  +      G +       +      +    + G + +DD + L LRIA   G++RNI+F F    DTA+SV  EMV +L +TD DV  IAE ID  I  L+P W
Sbjct:   10 EFSEFVEVDPTGRYGRYNEVLGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLRNPEDLERLYREIHLLKTLKHNNIMKFYTSWVDTTNRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCRQILKGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAVLRKSHADRCVGTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECNNPAQIYKKVITVGTLNSQGKKPEALFKVKDPEVRRFVEKCLVTVSXRLSARELLRDPFLQVDDYGYNLRPTEDQRDMYEIGPLLRQPHSSLHQSNSSLSNGHGNYLGYETENDLDYNPIDY----GLSEIDLFACQEDEHFGDVDLTIKGRRREDDDIFLRLRIADKEGRIRNIYFPFDTENDTALSVAREMVSELDITDQDVTKIAEMIDGEITTLVPEW 446          

Query:   73 EADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQP-TARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQ-FRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGW 1317
            + ++VE DP+ RY R          +  Y+AFDE++GIEVAWNQVK+  +LR+ EDLE+LYSEVHLLK+L H+NIIKFYNSWVD     IN+ITE+FTSG+LRQYR+K+K+VD +A++ W+RQIL GL +LH+H+PP+IHRDLKCDNIF+NGN GEVKIGDLGLA +++Q  +A SVIGTPEFMAPELYEEEYNELVDIY+FGMC+LE+VTFEYPY EC + AQIFKKVTSG+KPASL KV D  +K FIEKC+V+ SERL AKELL DPFLQ D+  E I   L+  + S KV  L  +  L +   +    L       S+    +  +   +++ N+ F + G +  DD++ L LRIA + G  RNIHF F +  DTA++V SEMV++L LTD DV+ IAE ID  I   +P W
Sbjct:  398 DIEFVEVDPTGRYGR----------ELRYRAFDELEGIEVAWNQVKVADLLRNSEDLERLYSEVHLLKTLKHKNIIKFYNSWVDAKHENINLITEIFTSGTLRQYRRKHKHVDLRALKKWSRQILEGLWYLHNHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLELVTFEYPYVECSNAAQIFKKVTSGVKPASLAKVTDPGVKAFIEKCIVKVSERLPAKELLMDPFLQSDDDRESITRSLRPTHYSGKVSFLSSAQRLFVSFSSHCDMLDAE--GSSDQIDIETKDMDPSHETNRDFSVQGQRK-DDTIFLKLRIADSTGHFRNIHFPFDIGEDTAIAVASEMVQELDLTDQDVSTIAELIDSEIHSHIPDW 801          

Query:   37 NGMLSKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRD-----------PL-QLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLS--GMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            NG+L  ++P  +  ++VE DP+ RY RYNEILGKGA K VY+AFDE +GIEVAWNQVK+   L+SPEDLE+LY E+HLLK+L H NI+KFY SWVD     IN +TE+FTSG+L+QYR K+K V+ +A++NW RQILRGL++LHSH+PP+IHRDLKCDNIFINGN GEVKIGDLGLA ++++  A   +GTPEFMAPE+YEE YNELVDIYSFGMC+LEMVTFEYPYSEC  PAQI+KKV SG KP +L KV D +++EF+EKCL  AS RLSA+ELL D FLQ+D     +R            PL + P   L   N   S   S D D D             +   ++ E    + ++   +S  G + +D  + L LRI    G VRNI+F F    DTA+SV +EMV +L +TD D   IA  ID  I  L+P W+
Sbjct:  338 NGLLH-LEP--DYCEFVEVDPTGRYGRYNEILGKGASKIVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKNWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCVLEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVREFVEKCLATASLRLSARELLNDRFLQIDECEYDLRSLDYGRHLDDMGPLARQPLLELHRSNSSFSNGYSNDYDXDAPN---EWTVDIESTGIELFEHHEDDHSDDVDISIKGKRGEDGGIFLRLRITDKEGXVRNIYFPFDTENDTALSVATEMVAELDITDQDETRIANMIDGEISMLVPDWQ 773          

Query:   10 GVGLVPPSSNGMLSKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSL----WGSALSGVPASSGVEQD---GSCCDNPE----------TVNCNGGI-----TSYPSFADFADEHSKVSVESAVLVDDASTKNDKVAESVDCSNTDGSC--MCSFFYDIKFQSNYA--------SNAEECSLV--NGITDKLVFPLLEIEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKKKVPVH 1947
            G  L   S+NG  S ++PP+ + D+VE DP++RYVRY+E+LGKGAFKTVYK FDEVDGIEVAWNQV+I  VLRSP+DLEKL+SEVHLL+SL HENI++  NSWVD+ K TINMITELFTSG+LRQYRKK+KNVD KAI+NWARQIL+GLV+LH HNPPIIHRDLKCDNIF+NG++G VKIGDLGLA +MQQPTA SVIGTPEFMA ELYEEEYNEL+DIYSFGMCMLEMVTFEYPYSEC++PAQI+KKVTSGIKPASLG V+D Q+KEFI KCLV ASERLSAKELLKDPFLQ  N +EP+RDPL LPNQ  K  +  KSGPLSMDID DYKQ+S STC GSNN   +  V E+QR +KN  F+L G ++DD+SVSLTLRIA + G+V NIHF FYL +DTA+SV SEMV+QL+L DHDVAFIAEFID+LIMKL PGWK                   + +     W S L+ V +   VEQ+   G     PE            N +G +      S PSF    D+ S+ S  S +LV+D S+K+D+++E  D  NTDG+C  +  +  + + + +Y+        S   EC  +  N    +  FP L      +                +D ELK ELD IE+QYQ WF +LSR RE+ALE T+KRW  KKK+PVH
Sbjct:    7 GGTLALASNNGTYSALEPPDAKGDFVETDPTSRYVRYDEVLGKGAFKTVYKGFDEVDGIEVAWNQVRIADVLRSPKDLEKLHSEVHLLRSLKHENIMELCNSWVDDKKKTINMITELFTSGNLRQYRKKHKNVDMKAIKNWARQILQGLVYLHGHNPPIIHRDLKCDNIFVNGHNGVVKIGDLGLAIIMQQPTATSVIGTPEFMATELYEEEYNELIDIYSFGMCMLEMVTFEYPYSECRNPAQIYKKVTSGIKPASLGNVSDPQVKEFILKCLVPASERLSAKELLKDPFLQPQNLVEPVRDPLLLPNQYPKSSSATKSGPLSMDIDADYKQISSSTCTGSNNEGTRFPVPEYQREHKNKVFKLKGKESDDNSVSLTLRIADSSGRVWNIHFLFYLDSDTALSVASEMVDQLELADHDVAFIAEFIDHLIMKLSPGWKLSSNYSLNELTSFYTASAALENSVACPWDSVLTTVLSQPAVEQEALSGMTTTPPEGSLQADDFNYNDNRDGAVFHINYHSSPSFGYMEDQDSQTSGVSEILVEDVSSKDDRISELPD-YNTDGNCKYLNGYTSEPELRDSYSLRKLERNDSGVGECIPMNENAKVSETPFPKLSGAPNDMSMTSSSSSSLYLVGKSMDTELKLELDAIEAQYQNWFRDLSRRREEALESTKKRWTAKKKLPVH 687          

Query:   70 EEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSLWGSALSGVPASSGVEQDGSCCDNPETVNCNGGITSYPSFADFADEHSKVSVESAVLVDDASTKNDKVAESVDCS---NTDGS---------CMCSFFYDIKFQSNYASNAEECSLVNGITDKLVFPLLEIEA-PKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKKKVPV 1944
            +EA YVE+DP+ RYVR+ EILGKGAFKTVYKAFDEVDGIE+AWNQVKID VLRSPEDLEKLYSEVHLLKSL HENIIKFYNSWVD+ K T+NMITELFTSGSLRQYRKK+KNVD KAI+NWARQ+LRGLV+LHSHNPPIIHRDLKCDNIF+NGNHGEVKIGDLGLA VMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPY+ECK+PAQI+KKVTSGIKPASL KV DLQIKEFI KCL  ASERL AKELLKDPF Q +NP EPIR PLQLP++S K I L KSGP SMDID D+ QLS ST +  NNGSP   VLEFQR  K+++FRL   K +D+S+SLTLR   + G V+NIHF F L TDT  SV  EMVEQL+L +H+VAFIA+FIDY+IM+LLPGWK                           L G  + +         +N +    +G   S P+ A+  D+ S  S     L  DAS KNDK     D +   N  GS             +  D K Q N  S+ EE + +N      V    ++     V            AD D D  LK ELD I+ QYQ WF+ELSRMR +ALE T+KRW+ KKK+ V
Sbjct:    8 DEAAYVEKDPTGRYVRFKEILGKGAFKTVYKAFDEVDGIEIAWNQVKIDDVLRSPEDLEKLYSEVHLLKSLKHENIIKFYNSWVDDKKKTVNMITELFTSGSLRQYRKKHKNVDMKAIKNWARQVLRGLVYLHSHNPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYNECKNPAQIYKKVTSGIKPASLCKVTDLQIKEFIVKCLAPASERLPAKELLKDPFFQSENPKEPIRVPLQLPSRSPKSIILSKSGPFSMDIDPDHPQLSSST-STENNGSPDFPVLEFQRMYKSSEFRLRAKKINDNSISLTLRTVDSYGPVKNIHFPFSLDTDTVHSVVGEMVEQLELAEHEVAFIADFIDYVIMRLLPGWKPPR---------------------DDPLGGARSPNAEPPVLGNGNNHDCTISHGDGNSSPNLANAEDQDSLASAGLVTLTVDASKKNDKTVGFGDYNIGGNYKGSNGGHASEQESRDPYHEDYKLQRN-NSSIEEFTPMNKFQKSTVLSFDDLSGLSNVRSLTCSCSSLSLADIDQDPGLKQELDAIDLQYQHWFQELSRMRVEALEATKKRWMTKKKLAV 624          

Query:    1 MDTGVGLVPPSSNGMLSKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVY------KAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSLWGSALSGVPASSGVEQDG------------------SCCDNPETVNCNGGITSYPSFADFADEHSKVSVESAVLVDDASTKNDKV--------AESVDCSNTDGSCMCSFFYDIKFQSNYASNAEECS----LVNGI---TDKLVFPLLEIEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKKKVPV 1944
            M++G  L  P  + +    +P + E D+VE+DP+ RY+RYNEILG+GAFKTVY      + FDEVDGIEVAWNQVKID ++ S +DL KLYSEV+LLKSL HENIIKFY+SW+D+ + T+NMITELFTSG+LR YRKK+K V+ KAI+ WARQIL GLV+LHSH PPIIHRDLKCDNIF+NGN GEVKIGDLGLA VMQQPTA+SVIGTPEFMAPELYEE Y ELVDIYSFGMC+LEMVT EYPYSECK+PAQIFKKVTSGIKPASL KV+D Q+KEFIEKCLV ASERLSA+ELLKDPFLQV+NP +PI  PLQ P+++L+  +  KSG LSMD+D+D K  S+S C+ SN  +P   V E QRTN  ++FRL G KNDD+SVSLTLRIA  CG+VRNIHF FYL TDTAVSV +EMVE L+L DHDV FIAE IDYLIMKLLP WK                       WGS L+ +P+   ++QDG                  S   N       G   S  S     D +S+ S  S ++V++ S KND          +ES+  S ++     ++F D K Q      AE CS    ++N     +  ++   + +E P               ++ +D EL+ +LD IE+ YQ W +EL +M  +AL+ TR+ W+ KKK+ V
Sbjct:   45 MNSGAVLALPPVSNVFRTREPHDFEDDFVEKDPTGRYIRYNEILGRGAFKTVYDSDAYYRGFDEVDGIEVAWNQVKIDGLMHSVDDLAKLYSEVNLLKSLKHENIIKFYDSWIDDKQKTVNMITELFTSGNLRLYRKKHKYVEMKAIKGWARQILHGLVYLHSHRPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAVVMQQPTAQSVIGTPEFMAPELYEEAYTELVDIYSFGMCILEMVTLEYPYSECKNPAQIFKKVTSGIKPASLNKVSDPQLKEFIEKCLVPASERLSAEELLKDPFLQVENPKDPILYPLQPPSRTLRAYSF-KSGSLSMDMDSDCKPFSMSICSESNQENPHCPVFEVQRTNNKHEFRLKGTKNDDNSVSLTLRIADTCGRVRNIHFLFYLDTDTAVSVATEMVEHLELADHDVDFIAELIDYLIMKLLPWWKPSPDHFSCGELSPYSTNIDGQWPWGSVLTSIPSELAIDQDGFSGSDTTPKEDFVASEKSSVSKNDSNATFEGDCNS-SSLVKLEDRYSQGSRASEMIVENTSMKNDNCHDSNADVSSESLSNSMSELEIGGAYFEDCKLQP-----AEYCSGEGVVINEFPKNSGSVLGTSINVENP----TNSCSYVSSTEEDIIDLELQFKLDEIEAHYQHWIDELKKMMLEALDSTRRSWVAKKKLAV 722          

Query:    1 MDTGVGLVPPSSNGMLSKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVY------KAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSL----WGSALSGVPASSGVEQDGSCCDNPE-----TVNCNGGITSYPSFADF------------ADEHSKVSVESAVLVDDASTKNDKVAES-VDCSNTDGSCMCSFFYDIKFQSNYASNAEECSLVNGITDKLVFP----LLEIEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKKKV 1938
            M++G  L  P  + +    +P + E D+VE+DP+ RY+R NEILG+GAFKTVY      + FDEVDGIEVAWNQVKID ++ S +DL KLYSEV+LLKSL HENIIKFY+SW+D+ K T+NMITELFTSG+LRQYRKK+K V+ KAI+ WARQIL GLV+LHSH PPIIHRDLKCDNIF+NGN GEVKIGDLGLA VMQQPTA+SVIGTPEFMAPELYEE Y ELVDIYSFGMC+LEMVT EYPYSEC++PAQIFKKVTSGIKPASL KV+D Q+K+FIEKCLV ASERLSA ELLKDPFLQV+NP +PI  PLQ P+++L+  +  KSG LSMD+D+DYK  S+S  + SN  +P   + E QRT KNN+FRL G KND +SVSLTLRIA  CG+VRNIHF FY  TDTAVSV +EMVE L+L DHDV FIAE IDYLIMKLLP WK                     +L    WGS  + +P+   + QDG    +        V+ N  ++   + A F             D +S+ S  S +++++ S KND   +S  D S+   S   S   D+ F+       E C     + ++  FP     +   +  V             + D+D  LK +LD IE+ YQ W +EL+ M  +ALE TR+RW+ KKK+
Sbjct:   31 MNSGAVLALPPVSNVFRTREPHDFEDDFVEKDPTGRYIRNNEILGRGAFKTVYDSDAYYRGFDEVDGIEVAWNQVKIDGLMHSVDDLAKLYSEVNLLKSLKHENIIKFYDSWIDDKKKTVNMITELFTSGNLRQYRKKHKYVEMKAIKGWARQILHGLVYLHSHKPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAIVMQQPTAQSVIGTPEFMAPELYEEAYTELVDIYSFGMCILEMVTLEYPYSECQNPAQIFKKVTSGIKPASLNKVSDPQLKDFIEKCLVPASERLSADELLKDPFLQVENPKDPILYPLQPPSRTLRAYSF-KSGSLSMDMDSDYKPFSMSIYSESNQENPHCPIFEVQRTYKNNKFRLKGTKNDVNSVSLTLRIADTCGRVRNIHFLFYPDTDTAVSVATEMVEHLELADHDVDFIAELIDYLIMKLLPWWKPSPDHCSCGELSPYCTNIDGQTLMAWPWGSVSTSIPSELVIGQDGFSGSDTTPKEDFVVSENSSVSKIANNATFEGDCNSSSLVKLEDRYSQGSRASEMIIENTSMKNDNCHDSNDDLSSKCFSSSMSELRDVYFEDCKLQQTEYCVGEGVVINE--FPKNSGSVLGTSINVENLASSCSYVSSTEEDIDLGLKFKLDEIEAHYQHWIDELNEMMLEALESTRRRWMAKKKL 707          

Query:   37 NGMLSKVKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSLWGSALSGVPASSGVEQDGSCCDNPETVNCNGGITSYPSFADFADEHSKVSVESAVLVDDASTKNDKVAESVDCSNTDGSCMCSFFYDIKFQSNY-ASNAEECSLVNGITDKLVFPLLEIEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKKKV 1938
            +G++ +     +EA YVE+DP+ RYVR+ EILGKGAFKTVYKAFDEVDGIE+AWNQVKID VLRSPEDLEKLYSEVHLLKSL HENIIKFYNSWVD+ K T+NMITELFTSGSLRQYRKK+KNVD KAI+NWARQ+LRGLV+LHSHNPPIIHRDLKCDNIF+NGNHGEVKIGDLGLA VMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPY+ECK+PAQI+KKVTSGIKPASL KV DLQIKEFI KCL  ASERL AKELLKDPF Q +NP EPIR PL                        D+                 VLEFQR  K+++FRL   K +D+S+SLTLR   + G V+NIHF F L TDT  SV  EMVEQL+L +H+VAFIA+FIDY+IM+LLPGWK                           L G  + +         +N +    +G   S P+ A+  D+ S  S     L  DAS KNDK                  F D     NY  SN    S                +  +             ++ D D  LK ELD I+ QYQ WF+ELSRMR +ALE T+KRW+ KKK+
Sbjct:    5 HGLVMQGAEDEDEAAYVEKDPTGRYVRFKEILGKGAFKTVYKAFDEVDGIEIAWNQVKIDDVLRSPEDLEKLYSEVHLLKSLKHENIIKFYNSWVDDKKKTVNMITELFTSGSLRQYRKKHKNVDMKAIKNWARQVLRGLVYLHSHNPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYNECKNPAQIYKKVTSGIKPASLCKVTDLQIKEFIVKCLAPASERLPAKELLKDPFFQSENPKEPIRVPLH----------------------PDF----------------PVLEFQRMYKSSEFRLRAKKINDNSISLTLRTVDSYGPVKNIHFPFSLDTDTVHSVVGEMVEQLELAEHEVAFIADFIDYVIMRLLPGWKPPR---------------------DDPLGGARSPNAEPPVLGNGNNHDCTISHGDGNSSPNLANAEDQDSLASAGLVTLTVDASKKNDKTVG---------------FGDYNIGGNYKGSNGGHAS---------------EQESRDPYHEDYKLQRNNSNIDQDPGLKQELDAIDLQYQHWFQELSRMRVEALEATKKRWMTKKKL 550          

Query:   55 VKPPNEEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNP-MEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWK 1320
            ++P +  AD VE+DP+ RYVRY+++LGKGAFKTVY+AFDEVDGIEVAWNQV+ID VLRSPED EKLYSEV+LL+SL HENIIKF NSWVD+   TINMITELFTSG+LRQYR+K++N+D KAI+NWARQILRGLV+LH H+PPIIHRDLKCDNIF+NGNHGEVKIGDLGLA VMQ PTA+SVIGTPEFMAPELYEEEYNELVDIYSFGMC+LE+VT  YPYSEC++ AQI+KKVTSGIKPASL  V + QIKEFIEKCL+ ASERLSAKELLK PFLQ++ P +E I DPL +P+Q    ++LPKSGPL MD+D D KQLS STC GSNNGSP+  VLE+QR +KNN+F L GMKNDD+S SLTLRI+   G+VRNIHF FYL +DTA+SV SEMVEQL+L DHDVAFIAE ID LI+KLLPGWK
Sbjct:    1 MEPSDAGADLVEKDPTGRYVRYDDVLGKGAFKTVYRAFDEVDGIEVAWNQVRIDDVLRSPEDFEKLYSEVYLLRSLRHENIIKFSNSWVDDKNKTINMITELFTSGNLRQYRRKHRNIDIKAIKNWARQILRGLVYLHGHSPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQNPTAKSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCNYPYSECRNAAQIYKKVTSGIKPASLKTVGNTQIKEFIEKCLLPASERLSAKELLKHPFLQLEIPILEQICDPLPVPDQFPISLSLPKSGPLFMDMDIDEKQLSESTCTGSNNGSPKSPVLEYQRAHKNNEFGLKGMKNDDNSASLTLRISDLGGRVRNIHFIFYLDSDTAISVASEMVEQLELADHDVAFIAELIDSLIVKLLPGWK 425          

Query:   70 EEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEP------IRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSP--QVLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSLWGSALSGVPASSGVEQDGSCCDNPETVNCNGGITSYPS---FADFADEHSKVSVESAV----LVDDASTKND----KVAESVDCSNTDGSCMCSFFYDIKF-------QSNYASNAEECSLVNGITDKLVFPLLE-IEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKKK 1935
            +++D+ E+DP+ RYVRYNE LGKGAFKTVYKAFDEVDGIEVAW QV+I+ +L+SP+ LE+LYSEVHLLKSL H+NIIKFYNSWVD+   TIN+ITELFTSGSLRQYRKK+KNVD KAI+NWA+QILRGL +LHSHNPPIIHRDLKCDNIF+NGN+GEVKIGDLGLA VMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMC+LE+VT EYPY+ECK+PAQI+KKV+SGIKPASLGKV+D Q+K+FIEKCLV AS RLSA+ELLKD F   +N  EP      + D LQ  N    ++NLPK     MD+D +YK+LS+ST   S +G+P  + L+F+R NKNN F+L G K DD+S+S+TL IA  CG+ +NIHF FYL +DTA+S+  EMVEQL L + DVA IAE ID +I +L+P WK                     S+   A S    S  +   G+   +P       G +   +    +  A+   + +VESA+      DDA+  +D    K  E  D    + S  C F  D +        +  Y  N  E   +NG T       +E                   AD D   ELK E+DTI++QY + F+EL RMRE+A+E  + RWI K +
Sbjct:    9 DDSDFEEKDPTGRYVRYNEFLGKGAFKTVYKAFDEVDGIEVAWGQVEIEDLLQSPQQLERLYSEVHLLKSLKHDNIIKFYNSWVDDTNKTINLITELFTSGSLRQYRKKHKNVDLKAIKNWAKQILRGLHYLHSHNPPIIHRDLKCDNIFVNGNNGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCEYPYNECKNPAQIYKKVSSGIKPASLGKVSDPQVKQFIEKCLVPASLRLSAQELLKDAFFATENSKEPVYNHMHVDDSLQSSNFMPNLMNLPKPELQPMDMDPNYKKLSVSTHMKSISGTPHFRALQFERFNKNNLFKLRGEKIDDNSISMTLHIADPCGRAKNIHFAFYLDSDTALSIAGEMVEQLDLYNEDVAVIAELIDVMISELVPTWK-----------------PAFESMLCGANSSCEDSLVLHNGGTSLRHPSDSGSAKGTSDAVTEHLISLSANGEEQSTVESALSGMSTKDDATVASDANDIKSLECPDDECYEASDRCCFNGDRQVLDHERHKEGRYNGNIGEPVAMNGFTKDWEISCIESCSGMSNSLSLSSICSLSLADKDPSDELKLEVDTIDTQYHQCFQELLRMREEAIEKAKNRWITKSR 640          

Query:   79 DYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSLWGSALSGVPASSGVEQDGSCCDNPETVNCNGGITSYPSFADFADEHSKVSVESAVLVDDASTKNDKVAESVDCSNTDGSCMCSFFYDIKFQSNYASNAEECSLVNGITDKLVFPLLEIEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEK 1929
            ++ E+DP+ RYVRY+EILGKGAFKTVYKAFDEVDGIEVAWNQV I+ VL+S + LE+LYSEVHLLKSL HENIIKFYNSWVD+   TINMITEL TSG+LRQYRKK+K VD KAI+NWARQILRGL +LH+ +P IIHRDLKCDNI +NGN+GEVKIGDLGLA VMQQP ARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVT EYPYSECK+PAQI+KKVTSGIKPASL KVNDLQ+KEFIEKCLV AS RLSA +LLKDPFL  +N  E +    QLPN   K ++LP+S    MDID   K LS+ +C  S N SPQ   LE +R  +NN+FRL   KNDD++VSLTLRIA  CG+ RNIHF FYL +DTAVS+  EMVEQL L+  DVA IAE ID LI+KL+P W                                  SS V    S  +N  T    G    +    +  D  +  SV S    D ++  N  +A     + + GS  CS       QSN   + + CS   G++      ++                   AD D  +ELK ELD+I+S Y + F+EL + RE+A+E  ++RWI K
Sbjct:   13 EFAEKDPTGRYVRYDEILGKGAFKTVYKAFDEVDGIEVAWNQVDIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYNSWVDDKNKTINMITELLTSGNLRQYRKKHKTVDMKAIKNWARQILRGLQYLHTRSPRIIHRDLKCDNILVNGNNGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVTSGIKPASLVKVNDLQVKEFIEKCLVPASVRLSAIDLLKDPFLATENSKEVVSSLSQLPNVICKQVHLPQSESHHMDIDC--KMLSLGSCPKSINESPQFLTLELRRFTENNEFRLRAEKNDDNTVSLTLRIADPCGRARNIHFTFYLNSDTAVSIAEEMVEQLDLSSEDVAVIAELIDSLIVKLVPCWN--------------------------------TSSSVRNGSSELENHATSE-TGKTPDFSPLTNITDHEALQSVNS----DISAEYNMAIASDASTNKSLGSSSCS------LQSN-VFHIDSCS---GMSRNASLSII--------------CSLFLADKD-GSELKLELDSIDSHYNQCFQELMKTREEAIENAKRRWISK 567          

Query:   82 YVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQ--VLEFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSLWGSALSGVPASSGVEQDGSCCDNPETVNCNGGITSYPSF---ADFADEHSKVSVESAVLVDDASTKNDKVAESVDCSNTDGS---CMCSFFYDIKFQSNYASNAEECSLVNGITDKLVFPLLEIEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKK 1932
            + E+DP+ RY+R +E LGKGAFKTVYKAFDEVDGIEVAWNQV I+ VL+S + LE+LYSEVHLLKSL HENIIKFY+SWVD+   TIN+ITELFTSGS+RQYRKK+K VD KAI+NWARQILRGL +LH+H+PPIIHRDLKCDNIF+NGN GEVKIGDLGLA VMQQP ARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVT EYPYSECK+PAQI+KKV+SGIKPASLGKV+D Q+K FIEKCLV AS RL A ELLKDPFL  +N  E +   LQLPN   + ++L +S    MDID   K+LS+ +C  S N SPQ   LE  R  +NN+FRL G KN+D++VSLTLRIA  CG+ RNIHF FYL +DTAV +  EMVEQL L   DVA IAE ID LI KL+P W                                  S  V    S  +N  T          P F    +  D  +K SV S    D ++  N  +A     + + GS   C+ S  YD++F       ++         D  +     +     M           AD D  +ELK ELD+I+S Y +  +EL +MRE+A+E  +KR I KK
Sbjct:   14 FAEKDPTGRYIRNDEFLGKGAFKTVYKAFDEVDGIEVAWNQVNIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYSSWVDDKNKTINIITELFTSGSMRQYRKKHKTVDMKAIKNWARQILRGLHYLHTHSPPIIHRDLKCDNIFVNGNTGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVSSGIKPASLGKVSDHQVKVFIEKCLVPASTRLPAIELLKDPFLATENSKELVSSSLQLPNLISRQVHLLQSESHLMDIDC--KKLSVGSCTKSINESPQFSTLELSRFTENNEFRLRGAKNNDNTVSLTLRIADPCGRARNIHFTFYLDSDTAVLIAEEMVEQLDLLTEDVAVIAELIDNLIAKLVPSWN--------------------------------TSPSVRNGSSELENHSTSEA----VKKPDFLPLTNMTDLETKQSVNS----DISAEYNMAIASDSGTNKSLGSSDCCLQSNMYDLEFGMLEDGISKHNKSTRNSNDSYIGSFSGMSRNASM---SSICSLSLADKD-GSELKQELDSIDSHYNQCLQELMKMREEAIENAKKRGITKK 592          

Query:   70 EEADYVERDPSNRYVRYNEILGKGAFKTVYKAFDEVDGIEVAWNQVKIDTVLRSPEDLEKLYSEVHLLKSLNHENIIKFYNSWVDNHKNTINMITELFTSGSLRQYRKKYKNVDTKAIRNWARQILRGLVFLHSHNPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYSECKSPAQIFKKVTSGIKPASLGKVNDLQIKEFIEKCLVQASERLSAKELLKDPFLQVDNPMEPIRDPLQLPNQSLKVINLPKSGPLSMDIDTDYKQLSISTCAGSNNGSPQVL---EFQRTNKNNQFRLSGMKNDDDSVSLTLRIAYACGKVRNIHFFFYLATDTAVSVTSEMVEQLKLTDHDVAFIAEFIDYLIMKLLPGWKXXXXXXXXXXXXXXXXXXXMSSL---WGSALSGVPASSGVEQ------DGSCCDNPETVNCNGGITSYPSFADFADEHSKVSVESAVLVDDASTKNDKVAESVDCSNTDGSCMCSFFYDIKFQSNYASNAEECSLVNGITDKLVFPLLEIEAPKVMXXXXXXXXXXXADNDLDAELKSELDTIESQYQRWFEELSRMREKALEVTRKRWIEKKKVPV 1944
            ++   VE+DP+ RY RY+E+LGKGAFKTVYKAFDEVDGIEVAWNQ+ I+ V++SP++LEKLYSEVHLLKSL HENIIK Y+SWVD   + INMITELFTSGSLRQYRKK+KNVD KAI+NWARQILRGL FLHSHNPP+IHRDLKCDNIF+NGN+G+VKIGDLGLA VMQQPTARSVIGTPEFMAPELYEEEYNELVD+YSFGMC+LEM+T EYPYSECK+PAQI+KKVTSGIKPASL +VND ++K+FIEKCLV AS RL A ELLKDPFL   N  E   D L LPN   K +N P   P  M+ID++ K  S ++    +  + QV    +  R  +NN+FRL G KN D ++SLTLRIA A G  RNIHF FY+ +DT +S+  EMVE L+L D DVA IAE I  +I KL+P WK                      L   W    +     S  E       DG   D  E+V+           +D + E+  V     +  D    + +       C  ++G              N   +   C   +G +++    ++   +P               D D   EL+ E++ IE QYQ+ F EL +MRE+A+E  +KRW  KK + V
Sbjct:    6 DDVGVVEKDPTLRYARYDEMLGKGAFKTVYKAFDEVDGIEVAWNQISIEDVMQSPQNLEKLYSEVHLLKSLKHENIIKMYSSWVDEKSSNINMITELFTSGSLRQYRKKHKNVDMKAIKNWARQILRGLCFLHSHNPPVIHRDLKCDNIFVNGNNGQVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDVYSFGMCILEMITCEYPYSECKNPAQIYKKVTSGIKPASLARVNDPEVKQFIEKCLVPASMRLPASELLKDPFLATGNTKEIYHDNLLLPNPPSKSLNPPTCEPHPMEIDSNVKHTSPASTVERDKETSQVSSNHDILRKTENNEFRLRGEKNADRTISLTLRIADANGGARNIHFPFYIDSDTTISIAEEMVEHLELKDEDVAVIAELIHNMIFKLVPDWKPLCENSSGTDNLYRPLEPQNEQLNCHWTLGSNNFDMKSMYEDLGHSQLDGEDQDKQESVS-----------SDISAEYGTV-----IATDAKGVEQNCFILHECCKGSNG-------------LNTNPDVRICGQEDGNSNQSENSVVSCCSPSENLDRLSKCSLTALDQDHLDELQLEIEAIEIQYQQSFRELMKMREEAIENVKKRWTSKKNISV 613