ppa002664m, ppa002664m (mRNA) Prunus persica

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKP 1419
            K  YKAFDEV+GIEVAW QV IED+LQSP+QLERLYSEVHLLKSLKH NI+KF NSWVDD NKTIN+ITELFTSGSLRQYRKKHKNVD+KAIKNWA+ ILRGLHYLHSHNPPIIHRDLKCDN+FVNGNNGE+KIGDLGLAIVMQQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMC+LE+VTCEYPY+ECKNPAQIY+KV+SGIKPASL KV +PQVKQFIEKCLVPAS+RL+A ELLKD F AT+N KE                        P+ + T+    S+ +  KS++ T +   L+F RF +NN F+LR E+  D ++S+TL IAD CGR +NIHF FYLDSDTA+SIAGEMVEQLDL +EDV+VIAELID +I +LVP WKP
Sbjct:  174 KTVYKAFDEVDGIEVAWGQVEIEDLLQSPQQLERLYSEVHLLKSLKHDNIIKFYNSWVDDTNKTINLITELFTSGSLRQYRKKHKNVDLKAIKNWAKQILRGLHYLHSHNPPIIHRDLKCDNIFVNGNNGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCEYPYNECKNPAQIYKKVSSGIKPASLGKVSDPQVKQFIEKCLVPASLRLSAQELLKDAFFATENSKE------------------------PLSVSTHK---SMSTHMKSISGTPHFRALQFERFNKNNLFKLRGEKIDDNSISMTLHIADPCGRAKNIHFAFYLDSDTALSIAGEMVEQLDLYNEDVAVIAELIDVMISELVPTWKP 540          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPA------HQNILS--------PLAYAEDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMNDACPDMSSICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKKKIA 1935
            K  YKAFDEV+GIE+AW QV I+DVL+SPE LE+LYSEVHLLKSLKH+NI+KF NSWVDDK KT+NMITELFTSGSLRQYRKKHKNVDMKAIKNWAR +LRGL YLHSHNPPIIHRDLKCDN+FVNGN+GE+KIGDLGLAIVMQQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMCMLEMVT EYPY+ECKNPAQIY+KVTSGIKPASL KV + Q+K+FI KCL PAS RL A ELLKDPF  ++N KE                        P+ +  +                 +  VLEF R  +++EFRLRA++  D ++SLTLR  D+ G V+NIHF F LD+DT  S+ GEMVEQL+L+  +V+ IA+ ID +IM+L+PGWKP              + P       H   +S         LA AEDQD+ A      SA      V  +  N K      Y+      GS+G  +S         +++S +    D  +  +              S +D+D    LK EL AID+QY              ++  KKRW+ KKK+A
Sbjct:   42 KTVYKAFDEVDGIEIAWNQVKIDDVLRSPEDLEKLYSEVHLLKSLKHENIIKFYNSWVDDKKKTVNMITELFTSGSLRQYRKKHKNVDMKAIKNWARQVLRGLVYLHSHNPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYNECKNPAQIYKKVTSGIKPASLCKVTDLQIKEFIVKCLAPASERLPAKELLKDPFFQSENPKE------------------------PIRVPLH----------------PDFPVLEFQRMYKSSEFRLRAKKINDNSISLTLRTVDSYGPVKNIHFPFSLDTDTVHSVVGEMVEQLELAEHEVAFIADFIDYVIMRLLPGWKPPRDDPLGGARSPNAEPPVLGNGNNHDCTISHGDGNSSPNLANAEDQDSLA------SAGLVTLTVDASKKNDKTVGFGDYNIGGNYKGSNGGHAS---------EQESRDPYHEDYKLQRNN-------------SNIDQD--PGLKQELDAIDLQYQHWFQELSRMRVEALEATKKRWMTKKKLA 551          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKP 1419
            K  YKAFD+V+GIEVAW QV I++VLQSP++LERLYSEVHLLKSLKH+NI+KF NSW+DD NKT+N+ITELFTSGSLRQYRKKHK VDMKA+K WAR IL GL+YLH+HNPPIIHRDLKCDN+F+NGN GE+KIGDLGLA VMQQ  A +VIGTPEFMAPELYDE YNEL DIYSFGMCMLEMVT EYPYSEC+N AQIY+KV++GIKPA+LSK+++ +VK FIEKCLVPAS RL+A +LL DPF   D L +                        P+ L   D    I S   SV+    S  +E  R    N F L+ E N + ++SL LRIAD  GR+RNIHF FYLDSDTA+S++ EMVEQL+L+ ++V+ IAELID L++ L+P WKP
Sbjct:   45 KTVYKAFDQVDGIEVAWNQVRIDEVLQSPDELERLYSEVHLLKSLKHKNIIKFYNSWIDDGNKTVNIITELFTSGSLRQYRKKHKKVDMKAVKGWARQILMGLNYLHNHNPPIIHRDLKCDNIFINGNQGEVKIGDLGLATVMQQANARTVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTLEYPYSECRNSAQIYKKVSNGIKPAALSKIKDLEVKMFIEKCLVPASQRLSAKKLLNDPFFQVDGLTKN----------------------HPLQLP--DILPIITSMDNSVDGGPYSLCMEVQRAKGGNFFLLKGEGNDENSISLILRIADQNGRLRNIHFMFYLDSDTALSVSSEMVEQLELADQNVTFIAELIDLLLIMLIPTWKP 414          

Query:  247 YKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQP-TAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQNILSPLAYAEDQDNQATMISD--TSAC 1554
            Y+AFDE+EGIEVAW QV + D+L++ E+ ERLYSEVHLLK+LKH+NI+KF  SWVD +N+ IN ITE+FTSG+LRQYRKKHK+VD++A+K W+R IL GL YLHSH+PP+IHRDLKCDN+FVNGN GE+KIGDLGLA +++Q  +AHSVIGTPEFMAPELY+EEYNELVDIY+FGMC+LE+VT EYPY EC N AQIY+KVTSGIKPASL+KV++P+V+ FI+KC+   S RL+A ELL+DPFL +D                         +  P    ++D   +  S + S+ E+S              +F+++ ++    T+ L LRIAD+ G +RNIHF F + +DTA+S+AGEMVE+LDL+ +DVS IA +ID  I  ++  W P             GD+ + +  +S +   E + +   ++++  TS+C
Sbjct:   43 YRAFDELEGIEVAWNQVKVADLLRNSEEFERLYSEVHLLKTLKHKNIIKFYISWVDTRNENINFITEIFTSGTLRQYRKKHKHVDLRALKKWSRQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCLLELVTFEYPYVECANAAQIYKKVTSGIKPASLAKVKDPRVRAFIDKCIANVSDRLSAKELLRDPFLQSDE---------------ENGSVGRSLQPHPHHSGSHDHFNTGTSSKVSLPESS-------------RDFKVQGQRRDVNTIFLKLRIADSKGHIRNIHFPFDIGADTAISVAGEMVEELDLTDQDVSTIAAMIDSEIRSIISDWPPSREVF--------GDNLSTEVAISDICPPESEGDALPLMNESATSSC 445          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTE-----NNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKP 1419
            K  Y+AFDE EGIEVAW QV + D LQSPE LERLY E+HLLK++KH NI+KF  SWVD  N+ IN +TE+FTSG+LRQYR+KHK V+++A+K+W R ILRGL YLHSH+PP+IHRDLKCDN+FVNGN GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+EEYNELVDIYSFGMC+LEMVT EYPYSEC +PAQIY+KV SG KP +L KV++P+V++F+EKCL   S+RL+A ELL+DPFL  D+ +                      + RP++            CR+  ++    + +E + + E     N +  ++ ++  D  + L LRIAD    +RNI+F F ++ DTA+S+A EMV +LD++ +DV+ IA++ID  I  LVP WKP
Sbjct:   37 KTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTMKHNNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRQKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVREFVEKCLASVSLRLSARELLQDPFLRIDDCES---------------------DLRPIE------------CRREPDDMMEPTGIELFEYHEDEHPANVDISIKGKRREDDGIFLRLRIADKEDHIRNIYFPFDIEMDTALSVATEMVAELDITDQDVTKIADMIDGEIASLVPEWKP 402          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWK 1416
            K  Y+AFDE EGIEVAW QV + D LQSPE+LERLY E+HLLK+LKH NI+KF  SWVD  N+ IN +TE+FTSG+LRQYR KH+ V+++A+K+W R ILRGL YLH+H PP+IHRDLKCDN+FVNGN GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+EEYNELVDIYSFGMC+LEMVT EYPYSEC +PAQIY+KV SG KP +L KV++P+V+QF+EKCL   ++RL+A ELLKDPFL +D   +   DL                E  P+        + I       NE    +  E     EN +  +   +  D  + L LRI+D  GRVRNI+F F +++DTA+S+A EMV +LD++ +DV+ IA++ID  I  LVPGWK
Sbjct:   36 KTVYRAFDEYEGIEVAWNQVKLNDFLQSPEELERLYCEIHLLKTLKHNNIMKFYTSWVDPANRNINFVTEMFTSGTLRQYRLKHRRVNIRAVKHWCRQILRGLLYLHNHKPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVRQFVEKCLATVTLRLSARELLKDPFLQSD---DYGSDL------RPIEYQRDLGEVGPL---PRLPHYGIHHIEFERNEIDLFTYQED-EHLENVDISIEGRKRDDHGIFLRLRISDKEGRVRNIYFPFDMETDTALSVAMEMVSELDITDQDVTKIADMIDDEIASLVPGWK 415          

Query:  232 SVKCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQ-QPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWK 1416
            ++K  YKA DEV G+EVAW QV + +VL+SP++L+RLYSEVHLL +L H +I++F  SW+D + KT N ITE FTSG+LR+YRKK+K VD++AIK WAR ILRGL YLH H+PP+IHRDLKCDN+FVNG+ GE+KIGDLGLA +++   +AHSVIGTPEFMAPELY+E YNELVD+YSFGMC+LEM+T EYPYSEC NPAQIY+KVTSG  P +  ++++ + ++FI KCLV AS RL A ELL DPFLA+D  K                        +P   D   +K  +   R   N T   ++                    D T+ L ++ AD  G  RNI+F F + +DT + +A EMV++L+++  +   IA++ID  I  LVP WK
Sbjct:   39 AMKTVYKAIDEVLGMEVAWNQVKLNEVLRSPDELQRLYSEVHLLSALNHDSIIQFYTSWIDVERKTFNFITEFFTSGTLREYRKKYKRVDIRAIKCWARQILRGLVYLHGHDPPVIHRDLKCDNIFVNGHLGEVKIGDLGLAAILRGSQSAHSVIGTPEFMAPELYEENYNELVDVYSFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPGAFYRIQDLEAQRFIGKCLVTASKRLPAKELLLDPFLASDEAKR--------------LPKPKLGSQKPFLNDIRIEKLRLSDDRVRTNMTITGTL-----------------NPDDDTIFLKVQTADKDGSARNIYFPFDIVTDTPIDVAMEMVKELEITDWEPFEIADMIDGEISALVPQWK 403          

Query:  232 SVKCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQ-QPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWK 1416
            ++K  YKAFDE  G+EVAW QV + DV  SP+ L+RLYSEVHLLK+L H +I++F  SW+D    T N I+E+FTSG+LR+YR+K+K VD+ A+KNWAR IL GL YLH H+PP+IHRDLKCDN+FVNG+ G++KIGDLGLA +++    AHSVIGTPEFMAPELY+EEY+ELVD+YSFGMC+LEM+T EYPY EC NPAQIY+KVTSG  P +  ++E+ + ++F+ +CL   + RL A ELL DPFLA D+ ++    L                E  P    TN +K       +S + T   ++                    D T+ L + I+D  G  RNI+F F + SDT + +A EMV +L+++  +   IA++I++ I  LVP WK
Sbjct:   39 AMKTVYKAFDEFLGMEVAWNQVKLNDVFNSPDDLQRLYSEVHLLKNLDHDSIMRFHTSWIDLDGGTFNFISEMFTSGTLREYRQKYKRVDIGAVKNWARQILHGLAYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQHAHSVIGTPEFMAPELYEEEYDELVDVYSFGMCVLEMLTSEYPYCECSNPAQIYKKVTSGKLPEAFYRIEDVEAREFVGRCLEHVAKRLPAKELLMDPFLAVDHGEQM---LPMLKISSQKPSPNGTVEKIP-SFQTNPRK-------RSTDMTITGTI-----------------NPDDYTIFLKVAISDKDGLSRNIYFPFDIGSDTPIDVAAEMVRELEITDWEPFEIAKMIEEEIFALVPSWK 406          

Query:  232 SVKCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGL-AIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDN 987
            +VK  Y+AFD+ EGIEVAW QV + +  +    ++RL+SEV LL +LK+++I+   + W D+++ T+N ITE+ TSG+LR YRK+H++V +KA+K W+R +L+GL YLH+H+P IIHRDL C N+F+NGN G++KIGDLGL AIV +   AHSV+GTPE+MAPELY+E+Y E+VDIYSFGMC+LEMVT E PYSEC N A+IY+KVTSG+ P +++KV +P+VK FIEKC+     R +A+ELL DPF +  N
Sbjct:  566 AVKKVYRAFDQEEGIEVAWNQVQLRNFSEDKSMVDRLHSEVKLLSTLKNESIIVLYSVWKDNEHNTLNFITEVCTSGNLRDYRKRHRHVSIKALKKWSRQVLKGLEYLHTHDPCIIHRDLNCSNIFINGNIGQVKIGDLGLAAIVGKNHLAHSVLGTPEYMAPELYEEDYTEMVDIYSFGMCLLEMVTMEIPYSECDNIAKIYKKVTSGVGPLAMNKVSDPEVKFFIEKCIAQPRARPSASELLNDPFFSELN 818          

Query:  232 SVKCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGL-AIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPF 972
            +VK  Y+AFD+ EGIEVAW QV +         ++RL+SEV LLK+LK +NI+   N W ++ + T+N ITE+ TSG+LR+YRKKH++V MKA+K W++ IL+GL YLH H P IIHRDL C NVF+NGN G++KIGD GL A V +   AHSV+GTPEFMAPELY+E+Y ELVDIYSFGMC LEMVT E PYSEC N A+IY+KV SG +P ++ KV +P+VK FIEKCL     R +A+ELL DPF
Sbjct:   36 AVKRVYRAFDQEEGIEVAWNQVKLRAFSDDKPMIDRLFSEVRLLKTLKDKNIIALYNVWRNEDHNTLNFITEVCTSGNLREYRKKHRHVSMKALKKWSKQILKGLDYLHRHEPCIIHRDLNCSNVFINGNVGKVKIGDFGLAATVGKSHVAHSVLGTPEFMAPELYEEDYTELVDIYSFGMCFLEMVTLEIPYSECDNIAKIYKKVISGARPRAMDKVRDPEVKAFIEKCLAKPRARPSASELLNDPF 283          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSC---------DLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQNILSPLAYAEDQ---------------------DNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMV--QARLKEKSYEAGSGDSVVMN-----------DACPDMS---SICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKKK 1929
            K  YKAFDEV+GIEVAW QV IED+LQSP+QLERLYSEVHLLKSLKH NI+KF NSWVDD NKTIN+ITELFTSGSLRQYRKKHKNVD+KAIKNWA+ ILRGLHYLHSHNPPIIHRDLKCDN+FVNGNNGE+KIGDLGLAIVMQQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMC+LE+VTCEYPY+ECKNPAQIY+KV+SGIKPASL KV +PQVKQFIEKCLVPAS+RL+A ELLKD F AT+N KE            D                 E +PMD+D N +K S+ +  KS++ T +   L+F RF +NN F+LR E+  D ++S+TL IAD CGR +NIHF FYLDSDTA+SIAGEMVEQLDL +EDV+VIAELID +I +LVP WKP            C D     N  + L +  D                      + Q+T+ S  S  S +     AS +    +S +   DEC   SD    + D  V    R KE  Y    G+ V MN           ++C  MS   S+ S+  LSL DKD  DELK E+  ID QYHQC           I+ AK RWI K +
Sbjct:   35 KTVYKAFDEVDGIEVAWGQVEIEDLLQSPQQLERLYSEVHLLKSLKHDNIIKFYNSWVDDTNKTINLITELFTSGSLRQYRKKHKNVDLKAIKNWAKQILRGLHYLHSHNPPIIHRDLKCDNIFVNGNNGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCEYPYNECKNPAQIYKKVSSGIKPASLGKVSDPQVKQFIEKCLVPASLRLSAQELLKDAFFATENSKEPLSVSTHKSSVDDSLQSSNFMPNLMNLPKPELQPMDMDPNYKKLSVSTHMKSISGTPHFRALQFERFNKNNLFKLRGEKIDDNSISMTLHIADPCGRAKNIHFAFYLDSDTALSIAGEMVEQLDLYNEDVAVIAELIDVMISELVPTWKPAFESMLCGANSSCEDSLVLHNGGTSLRHPSDSGSAKGTSDAVTEHLISLSANGEEQSTVESALSGMSTKDDATVAS-DANDIKSLECPDDECYEASDRCCFNGDRQVLDHERHKEGRYNGNIGEPVAMNGFTKDWEISCIESCSGMSNSLSLSSICSLSLADKDPSDELKLEVDTIDTQYHQCFQELLRMREEAIEKAKNRWITKSR 643          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGW--KPXXXXXXXXXXXXCGDHPAHQNILSPLAYAEDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMN----DACPDMSSICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKK 1926
            K  YKAFDEV+GIEVAW QV+IEDVLQS +QLERLYSEVHLLKSLKH+NI+KF +SWVDDKNKTIN+ITELFTSGS+RQYRKKHK VDMKAIKNWAR ILRGLHYLH+H+PPIIHRDLKCDN+FVNGN GE+KIGDLGLAIVMQQP A SVIGTPEFMAPELY+EEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIY+KV+SGIKPASL KV + QVK FIEKCLVPAS RL A ELLKDPFLAT+N KE                     E+  MD+D   +K S+GSC KS+NE+   S LE  RFTENNEFRLR  +N D TVSLTLRIAD CGR RNIHF FYLDSDTA+ IA EMVEQLDL  EDV+VIAELID LI KLVP W   P                   +    PL    D + + ++ SD    SA+Y +  AS +     +    S +CC  S+        +     K       S DS + +         MSSICS   LSL DKD   ELK EL +ID  Y+QC           I+NAKKR I KK
Sbjct:   36 KTVYKAFDEVDGIEVAWNQVNIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYSSWVDDKNKTINIITELFTSGSMRQYRKKHKTVDMKAIKNWARQILRGLHYLHTHSPPIIHRDLKCDNIFVNGNTGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVSSGIKPASLGKVSDHQVKVFIEKCLVPASTRLPAIELLKDPFLATENSKELVSSSLQLPNLISRQVHLLQSESHLMDIDC--KKLSVGSCTKSINESPQFSTLELSRFTENNEFRLRGAKNNDNTVSLTLRIADPCGRARNIHFTFYLDSDTAVLIAEEMVEQLDLLTEDVAVIAELIDNLIAKLVPSWNTSPSVRNGSSELENHSTSEAVKKPDFLPLTNMTDLETKQSVNSD---ISAEYNMAIASDS---GTNKSLGSSDCCLQSNMYDLEFGMLEDGISKHNKSTRNSNDSYIGSFSGMSRNASMSSICS---LSLADKDG-SELKQELDSIDSHYNQCLQELMKMREEAIENAKKRGITKK 592          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVP-----GWKPXXXXXXXXXXXXCGDHPAHQNILSPLAYAEDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMNDACPDMSSICSLSE--LSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKKKI 1932
            K  YKAFDE+ GIEVAW QVS+EDVLQSP+QLERLYSEVHLLKSLKH+NI+KF NSWVDD NKTINMITELFTSGSLR+YRKKHKNVD+KAIKNWAR ILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGE+KIGDLGLA VMQQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMC+LEMVTCEYPYSECKNPAQIY+KVTSGIKPASL KV +P VK+FIEKC+VPAS+RL A ELLKDPFLAT+N KE                     E+ PMD+D+N +K S+GSC KS++E+ + S  EF R T  NEFRLR E+N D T+SLTLRI D CG V+NIHF FYLDSDT +SIA EMVEQLDLS+EDV++IAELID LI+KLVP     G                    A ++   PLA  + Q+ Q +++S+ S          AS N K   S+ Y+ D                        +YE GS D ++  D           SE  L     +  D+LK EL AID+QY+QC           I+NAKK+WI +KK+
Sbjct:   35 KTVYKAFDEINGIEVAWNQVSVEDVLQSPDQLERLYSEVHLLKSLKHENIMKFYNSWVDDNNKTINMITELFTSGSLRKYRKKHKNVDIKAIKNWARQILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILEMVTCEYPYSECKNPAQIYKKVTSGIKPASLCKVNDPLVKRFIEKCIVPASMRLPALELLKDPFLATENPKELVFASLHLPDLMLKQVSRGQSESYPMDIDSNHKKLSVGSCTKSMDESLHFSTSEFQRLTVKNEFRLRGEKNDDNTISLTLRIVDRCGGVKNIHFTFYLDSDTTLSIAEEMVEQLDLSNEDVAIIAELIDALILKLVPHLSQSGSTSSMPNGFSELHNDATFKVASKHDFLPLADLKGQETQDSLLSELSTELPLTVASDASTN-KPLGSSDYTID----------------------FNTYEFGS-DFMMHGDGTFKYGKYTKHSEKHLPSAKGEVQDDLKLELDAIDMQYNQCFRELSMMREEAIENAKKKWITRKKV 582          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQN----ILSPLAYAEDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMNDACPDMSSICSLS---ELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEK 1923
            K  YKAFDEV+GIEVAW QV IEDVLQS +QLERLYSEVHLLKSLKH+NI+KF NSWVDDKNKTINMITEL TSG+LRQYRKKHK VDMKAIKNWAR ILRGL YLH+ +P IIHRDLKCDN+ VNGNNGE+KIGDLGLAIVMQQP A SVIGTPEFMAPELY+EEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIY+KVTSGIKPASL KV + QVK+FIEKCLVPAS+RL+A +LLKDPFLAT+N KE    LS               E+  MD+D   +  S+GSC KS+NE+     LE  RFTENNEFRLRAE+N D TVSLTLRIAD CGR RNIHF FYL+SDTA+SIA EMVEQLDLS EDV+VIAELID LI+KLVP W                +H   +       SPL    D +   ++ SD    SA+Y +  A             SD     S G+ S   C +Q+             +V   D+C  MS   SLS    L L DKD   ELK EL +ID  Y+QC           I+NAK+RWI K
Sbjct:   36 KTVYKAFDEVDGIEVAWNQVDIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYNSWVDDKNKTINMITELLTSGNLRQYRKKHKTVDMKAIKNWARQILRGLQYLHTRSPRIIHRDLKCDNILVNGNNGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVTSGIKPASLVKVNDLQVKEFIEKCLVPASVRLSAIDLLKDPFLATENSKEVVSSLSQLPNVICKQVHLPQSESHHMDIDC--KMLSLGSCPKSINESPQFLTLELRRFTENNEFRLRAEKNDDNTVSLTLRIADPCGRARNIHFTFYLNSDTAVSIAEEMVEQLDLSSEDVAVIAELIDSLIVKLVPCWNTSSSVRNGSSELE--NHATSETGKTPDFSPLTNITDHEALQSVNSD---ISAEYNMAIA-------------SDASTNKSLGSSS---CSLQS-------------NVFHIDSCSGMSRNASLSIICSLFLADKDG-SELKLELDSIDSHYNQCFQELMKTREEAIENAKRRWISK 567          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSN-SSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQ----------------NILSPLAYA----EDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMNDACPDMSSICSLSELSL--VDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKKKIAV 1938
            K  YKAFDEV+GIEVAW Q+SIEDV+QSP+ LE+LYSEVHLLKSLKH+NI+K  +SWVD+K+  INMITELFTSGSLRQYRKKHKNVDMKAIKNWAR ILRGL +LHSHNPP+IHRDLKCDN+FVNGNNG++KIGDLGLAIVMQQPTA SVIGTPEFMAPELY+EEYNELVD+YSFGMC+LEM+TCEYPYSECKNPAQIY+KVTSGIKPASL++V +P+VKQFIEKCLVPAS+RL A+ELLKDPFLAT N KE   D                 E  PM++D+N +  S  S  +   ETS  SS  +  R TENNEFRLR E+N D T+SLTLRIAD  G  RNIHF FY+DSDT +SIA EMVE L+L  EDV+VIAELI  +I KLVP WKP                P ++                ++   L ++    EDQD Q ++ SD    SA+YG   A+ + K  E   +   ECC GS+G  ++PD  +    +E      S +SVV    C    ++  LS+ SL  +D+D  DEL+ E+ AI++QY Q            I+N KKRW  KK I+V
Sbjct:   32 KTVYKAFDEVDGIEVAWNQISIEDVMQSPQNLEKLYSEVHLLKSLKHENIIKMYSSWVDEKSSNINMITELFTSGSLRQYRKKHKNVDMKAIKNWARQILRGLCFLHSHNPPVIHRDLKCDNIFVNGNNGQVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDVYSFGMCILEMITCEYPYSECKNPAQIYKKVTSGIKPASLARVNDPEVKQFIEKCLVPASMRLPASELLKDPFLATGNTKEIYHDNLLLPNPPSKSLNPPTCEPHPMEIDSNVKHTSPASTVERDKETSQVSSNHDILRKTENNEFRLRGEKNADRTISLTLRIADANGGARNIHFPFYIDSDTTISIAEEMVEHLELKDEDVAVIAELIHNMIFKLVPDWKPLCENSSGTDNLYRPLEPQNEQLNCHWTLGSNNFDMKSMYEDLGHSQLDGEDQDKQESVSSD---ISAEYGTVIAT-DAKGVEQNCFILHECCKGSNGLNTNPDVRICG--QEDGNSNQSENSVV--SCCSPSENLDRLSKCSLTALDQDHLDELQLEIEAIEIQYQQSFRELMKMREEAIENVKKRWTSKKNISV 613          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQN-------------------ILSPLAYA-----EDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLK-EKSYEAGSGDSVVMNDACP----DMSSICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEK 1923
            K  YKAFDEV+GIEVAW  +S+EDV+Q+P+QLE+LYSE+HLLKSLKH N++K  NSWVDD   TINMITELFTSGSLRQYR KHKNVDMKAIKNWAR ILRGL +LH H+PPI+HRDLKCDN+FVNGN+G +KIGDLGLAIVMQQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMC+LEMVTCEYPYSEC NPAQIY+KVTSGIKPA+L+KV +P+VKQFIEKCLVPAS+RL+A+ELLKDPFLAT+N KE + D+                E  PM++D+  ++ S GS    + ETS  S  +  R TENN+F LR E+N ++T+SLTLRIA+ CG  RNIHF FY++SDTA+SIA EMVE L+L++EDVSVIAELI+ +I KLVP  KP                   QN                   +   L ++     +D + Q +++SD    S + G+  AS + KV E   +  DE   G D   S+ D     +    K+    S  S++ +  CP    D+SSICS   L+L DKD  + L+ E+ AID  + Q            I++ K+R  EK
Sbjct:   28 KTVYKAFDEVDGIEVAWNMISVEDVVQTPQQLEKLYSEIHLLKSLKHDNVIKLYNSWVDDTTGTINMITELFTSGSLRQYRNKHKNVDMKAIKNWARQILRGLCFLHCHSPPIVHRDLKCDNIFVNGNSGLVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILEMVTCEYPYSECNNPAQIYKKVTSGIKPAALAKVNDPEVKQFIEKCLVPASMRLSASELLKDPFLATENTKEINHDILELPNPHTKLVNPPTCEPHPMEIDSKSRRTSPGSSMGRIEETSQVSFFDLVRMTENNKFMLRGEKNAESTISLTLRIANACGGARNIHFPFYINSDTAISIAEEMVEHLELTNEDVSVIAELINDMIAKLVPNLKPLSEKLSSGTDQLYRPSSEVQNGEQFNCHWPLQSSDYDMKPVFKDLVHSWPVDGDDLEKQESVMSD---ISVECGITVAS-DSKVVEPDIFIFDEFWEGFDAFNSTSDVRFCGQEDGHKNQSENSSGSLINSCCCPFKNFDISSICS---LTLADKDPSEGLRLEIEAIDTYFEQRFRELEMMRVAAIESLKRRHGEK 611          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQN------------------------ILSPLAYAEDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMNDACP----DMSSICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKR 1911
            K  YKAFDEV+GIEVAW ++ +EDV+Q+P+QL +LYSEVHLLKSLKH N++K  NSWVDD   TINMITELFTSGSLRQYRKKHKNVDMKAIKNWAR ILRGL +LHS +PPI+HRDLKCDN+FVNGN+G +KIGDLGLAIVMQQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMC+LEMVTCEYPYSECKNPAQIY+KVTSGIKPA+L+KV +P+VKQFIEKCLVPAS+RL+A+ELLKDPFLAT+N KE + D                 E  PM++D+  ++ S GS    + ETS  S  +  R T+NN+  LR E+N ++T+SLTLRI D CG  RNIHF FY+DSDTA+SIA EMVE L+L++EDVSVIAELI+ +I KLVP  KP                   QN                        + S     +DQ+ Q +++SD SA     G+  AS + KV E   +  DE   G   N +S           K+    S  S++ +  CP    DMSSICS   L+L DKD  + L+ ++ AID  + +            I++AK+R
Sbjct:   28 KTVYKAFDEVDGIEVAWNRIGVEDVVQTPQQLGKLYSEVHLLKSLKHDNVIKLYNSWVDDTAGTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARQILRGLCFLHSQSPPIVHRDLKCDNIFVNGNSGLVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILEMVTCEYPYSECKNPAQIYKKVTSGIKPAALAKVNDPEVKQFIEKCLVPASMRLSASELLKDPFLATENTKEINHDTLQLPNPHIKLVNLPKCEPHPMEIDSYSRRTSPGSSMGRIEETSQVSFFDLVRMTDNNKLMLRGEKNAESTISLTLRIPDACGGARNIHFPFYMDSDTAISIAEEMVEHLELTNEDVSVIAELINDMIAKLVPNSKPLCEKLSSETNLLYRPSSEVQNGEQFNCHWPLQSSDYDMKAMYKDLVHSRPVDGDDQEKQESVMSDISAAC---GITIAS-DSKVVEPDIFIFDEFWEGF-FNSTSDIRFCGQEDGHKNQSENSVGSLINSCCCPFKNFDMSSICS---LTLADKDPSEGLRLDIEAIDTYFDRRFLELEMMRQEAIKSAKRR 605          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPA------HQNILS--------PLAYAEDQDNQA-----TMISDTSACSAQ---YGVPTASCNVKVSESAKYSSDECCT------GSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMNDACPDMSSICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKKKIAV 1938
            K  YKAFDEV+GIE+AW QV I+DVL+SPE LE+LYSEVHLLKSLKH+NI+KF NSWVDDK KT+NMITELFTSGSLRQYRKKHKNVDMKAIKNWAR +LRGL YLHSHNPPIIHRDLKCDN+FVNGN+GE+KIGDLGLAIVMQQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMCMLEMVT EYPY+ECKNPAQIY+KVTSGIKPASL KV + Q+K+FI KCL PAS RL A ELLKDPF  ++N KE                         MD+D +  + S  +  ++ N + +  VLEF R  +++EFRLRA++  D ++SLTLR  D+ G V+NIHF F LD+DT  S+ GEMVEQL+L+  +V+ IA+ ID +IM+L+PGWKP              + P       H   +S         LA AEDQD+ A     T+  D S  + +   +G      N K S     S  E             N SS +        +KS      D   +++     S  CS S LSL D D+   LK EL AID+QY              ++  KKRW+ KKK+AV
Sbjct:   42 KTVYKAFDEVDGIEIAWNQVKIDDVLRSPEDLEKLYSEVHLLKSLKHENIIKFYNSWVDDKKKTVNMITELFTSGSLRQYRKKHKNVDMKAIKNWARQVLRGLVYLHSHNPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYNECKNPAQIYKKVTSGIKPASLCKVTDLQIKEFIVKCLAPASERLPAKELLKDPFFQSENPKEPIRVPLQLPSRSPKSIILSKSGPFSMDIDPDHPQLSSSTSTEN-NGSPDFPVLEFQRMYKSSEFRLRAKKINDNSISLTLRTVDSYGPVKNIHFPFSLDTDTVHSVVGEMVEQLELAEHEVAFIADFIDYVIMRLLPGWKPPRDDPLGGARSPNAEPPVLGNGNNHDCTISHGDGNSSPNLANAEDQDSLASAGLVTLTVDASKKNDKTVGFGDYNIGGNYKGSNGGHASEQESRDPYHEDYKLQRNNSSIEEFTPMNKFQKSTVLSFDDLSGLSNV---RSLTCSCSSLSLADIDQDPGLKQELDAIDLQYQHWFQELSRMRVEALEATKKRWMTKKKLAV 632          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATD-NLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWK 1416
            K  Y+AFDEV+GIEVAW QV I+DVL+SPE  E+LYSEV+LL+SL+H+NI+KF NSWVDDKNKTINMITELFTSG+LRQYR+KH+N+D+KAIKNWAR ILRGL YLH H+PPIIHRDLKCDN+FVNGN+GE+KIGDLGLAIVMQ PTA SVIGTPEFMAPELY+EEYNELVDIYSFGMC+LE+VTC YPYSEC+N AQIY+KVTSGIKPASL  V N Q+K+FIEKCL+PAS RL+A ELLK PFL  +  + E+ CD                     MD+D ++++ S  +C  S N +  S VLE+ R  +NNEF L+  +N D + SLTLRI+D  GRVRNIHF FYLDSDTA+S+A EMVEQL+L+  DV+ IAELID LI+KL+PGWK
Sbjct:   32 KTVYRAFDEVDGIEVAWNQVRIDDVLRSPEDFEKLYSEVYLLRSLRHENIIKFSNSWVDDKNKTINMITELFTSGNLRQYRRKHRNIDIKAIKNWARQILRGLVYLHGHSPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQNPTAKSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCNYPYSECRNAAQIYKKVTSGIKPASLKTVGNTQIKEFIEKCLLPASERLSAKELLKHPFLQLEIPILEQICDPLPVPDQFPISLSLPKSGPLFMDMDIDEKQLSESTCTGSNNGSPKSPVLEYQRAHKNNEFGLKGMKNDDNSASLTLRISDLGGRVRNIHFIFYLDSDTAISVASEMVEQLELADHDVAFIAELIDSLIVKLLPGWK 425          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWK 1416
            K  YK FDEV+GIEVAW QV I DVL+SP+ LE+L+SEVHLL+SLKH+NI++ CNSWVDDK KTINMITELFTSG+LRQYRKKHKNVDMKAIKNWAR IL+GL YLH HNPPIIHRDLKCDN+FVNG+NG +KIGDLGLAI+MQQPTA SVIGTPEFMA ELY+EEYNEL+DIYSFGMCMLEMVT EYPYSEC+NPAQIY+KVTSGIKPASL  V +PQVK+FI KCLVPAS RL+A ELLKDPFL   NL E   D                     MD+D + ++ S  +C  S NE +   V E+ R  +N  F+L+ +++ D +VSLTLRIAD+ GRV NIHF FYLDSDTA+S+A EMV+QL+L+  DV+ IAE ID LIMKL PGWK
Sbjct:   53 KTVYKGFDEVDGIEVAWNQVRIADVLRSPKDLEKLHSEVHLLRSLKHENIMELCNSWVDDKKKTINMITELFTSGNLRQYRKKHKNVDMKAIKNWARQILQGLVYLHGHNPPIIHRDLKCDNIFVNGHNGVVKIGDLGLAIIMQQPTATSVIGTPEFMATELYEEEYNELIDIYSFGMCMLEMVTFEYPYSECRNPAQIYKKVTSGIKPASLGNVSDPQVKEFILKCLVPASERLSAKELLKDPFLQPQNLVEPVRDPLLLPNQYPKSSSATKSGPLSMDIDADYKQISSSTCTGSNNEGTRFPVPEYQREHKNKVFKLKGKESDDNSVSLTLRIADSSGRVWNIHFLFYLDSDTALSVASEMVDQLELADHDVAFIAEFIDHLIMKLSPGWK 445          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSN---SSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQNILSPLAYAEDQD--NQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMNDACPDMSSICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKKKIAVN 1941
            K  YKAFDEV+GIEVAW  VSIEDV+Q P QLERLYSEVHLLK+LKH+NI+K   SWVD+KNKTINMITELFTSGSLR YRKKH+ VD KAIKNWAR IL+GL+YLHS NPP+IHRDLKCDN+FVNGN GE+KIGDLGLA V+QQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMCMLEMVTCEYPY+EC+N AQIY+KVTS IKP SL KV++PQV+QFIEKCL+PAS R TA EL KDPFLA D  K+ +  L                E  PMD+D N+         KSV+   +   S  +E  R  EN EFRLR E++ D T S+ LRIAD  G+ R +HF FYL+SDTA +IA EMVE+L L+ ++V VIA++ID  IM+L+                      +H N  SP    ED +  NQ T+ S     + Q        ++K   SA Y      + +DGN +           E   +A S  S +  D+C  MS+I +   LS+ D D  ++LK EL  I+ Q++Q            I+NAK++WI KK+ AVN
Sbjct:   41 KTVYKAFDEVDGIEVAWNLVSIEDVMQMPGQLERLYSEVHLLKALKHENIIKLFYSWVDEKNKTINMITELFTSGSLRVYRKKHRKVDPKAIKNWARQILKGLNYLHSQNPPVIHRDLKCDNIFVNGNTGEVKIGDLGLATVLQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYNECRNQAQIYKKVTSNIKPQSLGKVDDPQVRQFIEKCLLPASSRPTALELSKDPFLARDGGKDSA--LLASSSTSSKYVRPPQLEHLPMDVDHNE--------NKSVSSNEDYPWSQTIELQRIAENKEFRLRGERSDDVTASMVLRIADPSGKCRIVHFAFYLESDTATAIAEEMVEELHLTSQEVVVIADMIDDFIMQLL-----------------SDRTSSHHNQNSPRLTHEDHEAANQQTVNSKDEEAAGQ--------SMKSDISADYYFP--YSANDGNAA----------MEAGRDAESMSSYL--DSCSMMSTIYN---LSISDNDYPEDLKTELNLIESQFNQSFQDLLKLKEDAIENAKRKWITKKQKAVN 561          

Query:  232 SVKCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWK----------PXXXXXXXXXXXXCGDHPA---HQNIL-SPLAYAEDQDNQATMISDTSACSAQYGVPTAS----CNVKVSESAK----YSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMNDACPDMSSICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKK 1926
            ++K  YKAFDEVEGIEVAW QV I++V+QSP+ LERLYSEVHLLKSLKH+N++KF N WVDD+ KTIN+ITELFTSGSLRQYR+KH  VD+KAIKNWAR +LRGL YLH+H PPIIHRDLKCDN+FVNGN+GE+KIGDLGLA VM  P A SVIGTPEFMAPELYDE Y+ELVDIYSFGMCMLEM T EYPYSEC N AQI++KV+ G+KPA+L+K+ N Q KQFI+KCLVPAS RL+A ELL+DPFL +DN    S  +                EA  MD+DTN +     +C+++     + SVLEF R  +N E +L  E+  D +VSL LRIAD CG  RNIHF FYLDSDTAMS+A EMVEQL+L+  DV+ IA+ ID LI+ LVPG +                          HP+   H  +L   + ++++ +   +   D+   +   G P +S     +V++  S+K    Y  DE  T   G     D   +   +       S  ++   D     S +   + +S+   +  D L GEL  I+ QY Q            ++ A+K+W+  K
Sbjct:   35 AMKTVYKAFDEVEGIEVAWSQVEIDEVMQSPDNLERLYSEVHLLKSLKHENVMKFYNYWVDDQKKTINVITELFTSGSLRQYRQKHPRVDLKAIKNWARQVLRGLDYLHTHQPPIIHRDLKCDNIFVNGNHGEVKIGDLGLATVMLTPRAKSVIGTPEFMAPELYDENYDELVDIYSFGMCMLEMFTLEYPYSECTNAAQIFKKVSKGVKPAALAKITNIQAKQFIDKCLVPASERLSAKELLQDPFLCSDN---SSVLVGTKFPSSLPKSVDVSLEALHMDVDTN-ESMCTSTCKRNDLGGPHRSVLEFTRTNKNTELKLTGEKLDDNSVSLVLRIADLCGHARNIHFLFYLDSDTAMSVAAEMVEQLELADCDVTFIADFIDLLIVNLVPGQQLMNDAVMSTSSESKMGESEHVITSQQHPSELTHDYVLVEGMMHSKEANASPSDYIDSLLNATNLGGPNSSEGSDISVQLDGSSKSLSEYGVDEYRTLECGAYKGTD---KLGCRHPLSNGSSNFAIFQMDQASHHSELVIGASVSIT--ENRDVLNGELGLIEAQYEQWFRELTRMREEALEGARKKWLPDK 612          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLD-TNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKL 1401
            K  YKAFDEVEGIEVAW  +SIEDVLQ P QL+RLYSEVHLL SLKH NI+K   SWVDD NK+INMITELFTSGSL  YRKKH+ VD KAI NWAR IL+GLHYLHS  PP+IHRDLKCDN+FVNGN G++KIGDLGLA VMQQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMCMLEMVTCEYPY EC+N AQIY+KVTSGIKP SLSKV++PQVKQFIEKCL+PA  R TA ELLKD  LA D  K+ +  L+               E RPMD++   +   SI S  KS  E +    +E  R  E+ EF+L  E+  D   S+ LRIA + G+ R + F+F L +DTA ++ GEMVE+LDLS  +V+VIAE+ID+LIMKL
Sbjct:   28 KTVYKAFDEVEGIEVAWNLMSIEDVLQMPGQLDRLYSEVHLLNSLKHDNIIKLFYSWVDDHNKSINMITELFTSGSLTLYRKKHRKVDPKAIMNWARQILKGLHYLHSQTPPVIHRDLKCDNIFVNGNTGKVKIGDLGLAAVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYRECRNQAQIYKKVTSGIKPQSLSKVDDPQVKQFIEKCLLPAPSRPTALELLKDQLLAVDGAKDST--LTASSNTTFKPAMPPQCEYRPMDVEYKKNTSVSICSSAKSSQECALLQTMEVQRVAESTEFKLSGERRDDVAASMALRIAGSSGQARKVDFDFNLKTDTARAVTGEMVEELDLSSHEVTVIAEMIDELIMKL 414          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNL------------KERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAH----QNILSPLAYAEDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSS 1662
            K  YKAFDEV+GIEVAW QV I+DVLQSP  LERLYSEV LLKSLKH NI++F NSW+DDKNKT+N+ITELFTSGSLR YRKKH+ V+MKA+KNWAR IL GL YLH   PPIIHRDLKCDN+F+NGN+GE+KIGDLGLA VM+Q  A SVIGTPEFMAPELYDE YNEL DIYSFGMCMLEMVT +YPY ECKN AQIY+KV+SGIKPASLS+V++P+VKQFIEKCL+PAS RL+A ELL DPFL  + L              +                    +   +DLD  D    I     + ++ S S  +E  R    N F L+ E+N + +VSL LRI D  GRVRNIHF FY + DTA  ++ EMVEQL+L+ ++V+ IAELID L++ ++P WK               DH  H    QN  S    A+ Q  + T+  DT        + + SCN     S +    +C   + G   S
Sbjct:   40 KTVYKAFDEVDGIEVAWNQVRIDDVLQSPNCLERLYSEVRLLKSLKHNNIIRFYNSWIDDKNKTVNIITELFTSGSLRHYRKKHRKVNMKAVKNWARQILMGLRYLHGQEPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFDYPYCECKNSAQIYKKVSSGIKPASLSRVKDPEVKQFIEKCLLPASERLSAKELLLDPFLQLNGLTMNNPLPLPDIVMPKEGAFGDRCLMSEGPPTTRPSKTLSIDLD-EDSNLPI----VTFSDNSGSRCIEVRRAKRGNFFVLKGEENDEQSVSLILRIVDENGRVRNIHFLFYQEGDTASKVSSEMVEQLELTDQNVTFIAELIDILLVNMIPTWKTDVTV----------DHLIHSQLNQNSRSHHNEAKPQKQEETVFHDTCE------LVSHSCNSDCPRSDE-EDKQCVDATKGEDKS 508          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNL--------------KERS----CDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWK 1416
            K  +K FDEV+GIEVAW QV I+D+LQSP+ LERLYSEV LLKSLKH+NI++F NSW+DDKNKT+N+ITELFTSGSLRQYRKKH+ V+MKA+K WAR IL GL YLHS +PPIIHRD+KCDN+F+NGN+GE+KIGDLGLA VM+Q  A SVIGTPEFMAPELYDE YNEL DIYSFGMCMLEMVT EYPY EC+N AQIY+KV+SGIKPASLSKV++P+V +FIEKCL+PAS RL+A ELL D FL  + L              KE S    C +S                   M+LD ++    + S     +  S ++ +E  R    N F L+ E+N + +VSL LRI D  GRVRNIHF F+ + DTA +++ EMVEQL+L+ ++V  IAELID L++ L+P WK
Sbjct:   40 KTVFKGFDEVDGIEVAWNQVRIDDLLQSPDCLERLYSEVRLLKSLKHKNIIRFYNSWIDDKNKTVNIITELFTSGSLRQYRKKHRKVNMKAVKCWARQILTGLKYLHSQDPPIIHRDIKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFEYPYCECRNSAQIYKKVSSGIKPASLSKVKDPEVMKFIEKCLLPASERLSAEELLLDSFLNVNGLVMNNPLPLPDIVMPKEGSFGERCLMS-------EGPPNARNRTMSMNLDEDNNLPIVIS-----SNNSGTNCIEVRRAKRGNFFVLKGEENDENSVSLILRIVDENGRVRNIHFLFFQEGDTASNVSSEMVEQLELTDKNVKFIAELIDVLLVNLIPNWK 438          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDN--LKERSCDLSXXXXXXXXXXXXXXXEAR-PMDLDTNDQKFSIG---SCRKSVN----------------------ETSNSSVLEFWRFTENN-----------EFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKP 1419
            K  Y+AFDE EGIEVAW QV + D LQSPE LERLY E+HLLK+LKH+NI+KF  SWVD  N+ IN +TELFTSG+LRQYR +HK V+++A+K+W R ILRGLHYLHSH+PP+IHRDLKCDN+FVNGN GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+E YNELVDIYSFGMC+LEMVT +YPYSEC +PAQIY+KV SG KP +L KV++P+VK FIEKCL   S+R++A ELL DPFL  D+     RS D+                    P +  + ++++S G   S   S+N                      ET  +  +E +    N+           +  ++ ++  D  + L LRIAD  GRVRNI+F F +++DTA+S+A EMV +LD+    V+ IA +ID  I  LVP W+P
Sbjct:   36 KTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTELFTSGTLRQYRLRHKRVNIRAMKHWCRQILRGLHYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFDYPYSECTHPAQIYKKVMSGKKPDALYKVKDPEVKCFIEKCLATVSLRVSARELLDDPFLRIDDGEFDLRSVDMEDSVGPLYRQPHHLPDYYNYPSNSSSLNRQYSNGNYPSNSSSLNRQYSNGYNSHHEYQNGWAYNPAETEETHGIELFESRNNDDQEEEKKSGNVDITIKGKRRDDGGLFLRLRIADKEGRVRNIYFPFDIETDTALSVATEMVAELDMDDHGVTKIANMIDGEISSLVPSWRP 468          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLK--ERSCDLSXXXXXXXXXXXXXXXEARPMD---LDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTE-----NNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKP 1419
            K  Y+AFDE +G+EVAW QV + D LQSPE LERLY E+HLLK+LKH+NI+KF  SWVD   + IN ITE+FTSG+LRQYR+KH  V++ A+K+W R IL GL YLHSH+PPIIHRDLKCDN+FVNGN GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+EEYNELVDIYSFGMC+LEMVT EYPYSEC +P QIY+KV SG KP +L KV++P V+QF+EKCL  AS RL+A ELLKDPFL  D+L       D S                   M     ++ D+           ++   +  ++ +   E     N +  ++  ++ D ++ L LRIAD  G VRNI+F F +++DTA+S+A EMV +LD++  +V+ IAE+ID  +  LVP W+P
Sbjct:   39 KTVYRAFDEYQGMEVAWNQVKLHDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDVSRRNINFITEMFTSGTLRQYRQKHMRVNIWAVKHWCRQILSGLLYLHSHDPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAVHCVGTPEFMAPEVYEEEYNELVDIYSFGMCVLEMVTFEYPYSECTHPVQIYKKVISGTKPEALYKVKDPMVRQFVEKCLATASRRLSARELLKDPFLQVDDLVFCPGDGDYSLMNYLRQPYLEHAYSNVSMMSNGLSESIDEDTPTEDRWDCEDDDIKADGIDLFNGHEDEPLGNVDITIKGRKSEDGSIFLRLRIADNDGHVRNIYFPFDIEADTALSVATEMVAELDITDHEVTRIAEMIDGEVSALVPDWRP 442          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLK--ERSCDLSXXXXXXXXXXXXXXXEARPMD---LDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTE-----NNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKP 1419
            K  Y+AFDE +G+EVAW QV + D LQSPE LERLY E+HLLK+LKH+NI+KF  SWVD   + IN ITE+FTSG+LRQYR+KH  V++ A+K+W R IL GL YLHSH+PPIIHRDLKCDN+FVNGN GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+EEYNELVDIYSFGMC+LEMVT EYPYSEC +P QIY+KV SG KP +L KV++P V+QF+EKCL  AS RL+A ELLKDPFL  D+L       D S                   M     ++ D+           ++   +  ++ +   E     N +  ++  ++ D ++ L LRIAD  G VRNI+F F +++DTA+S+A EMV +LD++  +V+ IAE+ID  +  LVP W+P
Sbjct:   39 KTVYRAFDEYQGMEVAWNQVKLHDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDVSRRNINFITEMFTSGTLRQYRQKHMRVNIWAVKHWCRQILSGLLYLHSHDPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAVHCVGTPEFMAPEVYEEEYNELVDIYSFGMCVLEMVTFEYPYSECTHPVQIYKKVISGTKPEALYKVKDPMVRQFVEKCLATASRRLSARELLKDPFLQVDDLVFCPGDGDYSLMNYLRQPYLEHAYSNVSMMSNGLSESIDEDTPTEDRWDCEDDDIKADGIDLFNGHEDEPLGNVDITIKGRKSEDGSIFLRLRIADNDGHVRNIYFPFDIEADTALSVATEMVAELDITDHEVTRIAEMIDGEVSALVPDWRP 442          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQP-TAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDN------LKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGW 1413
            K  YKAFD++EG+EVAW Q+ + D+L++ + LERL SEV LLK+LKH+NI+KF NSW+D KN  IN ITE+FTSG+LRQYR KHK VD++A+K W+R IL GL YLHSH+PP+IHRDLKCDN+FVNGN GE+KIGDLGLA ++    +AHS+IGTPEFMAPELYDEEYNELVDIY+FGMC+LE+VT EYPY EC N AQIY+KV+ G KP+SL+K+E+P+V+ FIEKC+  AS RL+A ELL DPFL  D       L+  +                   +A  M +  +   F+     +  ++    S ++  +        + ++     T+ L LRIAD+ G  +NIHF F +++DT++S+A EMV QLDL+ +DV+ IAE+ID  I   +P W
Sbjct:   40 KTVYKAFDQLEGLEVAWNQIKVGDILRNNDDLERLRSEVRLLKTLKHKNIIKFYNSWLDKKNNNINFITEVFTSGTLRQYRIKHKKVDVRALKKWSRQILSGLVYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLATILDNARSAHSIIGTPEFMAPELYDEEYNELVDIYAFGMCLLELVTFEYPYCECSNAAQIYKKVSDGEKPSSLAKIEDPEVRFFIEKCIAKASQRLSAQELLMDPFLRDDGEKIFYPLQSNTKASDGAGSSNSSMGYKYDRDASSMAIREHTGSFA----EEHPSDRYIHSTMD-PQAAAGRIITVESQMKDLNTIFLKLRIADSTGHAQNIHFPFDIEADTSISVATEMVVQLDLTDQDVTAIAEMIDAEIRAHIPDW 433          

Query:  247 YKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQP-TAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLS-HEDVSVIAELIDKLIMKLVPGWKP 1419
            Y+AFD++EGIEVAW QV ++D   S E L+RLYSEVHLLK+LKH++I+KF  SW+D ++ TIN+ITE+FTSG+LRQYRKKHK VD++A+K W+R IL GL YLHSH+PP+IHRDLKCDN+F+NGN GE+KIGDLGLA ++ +  +AHSVIGTPEFMAPELY+E+YN LVDIY+FGMC+LE+VT EYPYSEC N AQIYRKVTSGIKPA+L  V +PQV+ FIEKC+   S RL+A ELL DPFL     KE + ++S                                      N  + + +++    +E     +  ++    T+ L LRI D+ G++RNIHF F +++DT+ S+A EMVE+LDL+  +D+S IA++ID  I   +P W P
Sbjct:   37 YRAFDQLEGIEVAWNQVKLDDKFCSSEDLDRLYSEVHLLKTLKHKSIIKFYTSWIDHQHMTINLITEVFTSGNLRQYRKKHKCVDLRALKKWSRQILEGLVYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILHRARSAHSVIGTPEFMAPELYEEDYNVLVDIYAFGMCLLELVTFEYPYSECTNAAQIYRKVTSGIKPAALLNVTDPQVRAFIEKCIAKVSQRLSAKELLDDPFLKC--YKENTENVS----------------------------------SHKENGYNGNGIVDKLSDSEVGLLTVEGQRKDLNTIFLKLRITDSKGQIRNIHFPFNIETDTSFSVAIEMVEELDLTDDQDISTIAKMIDTEIHSHIPDWTP 393          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSN---SSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQNILSPLAYAEDQD--NQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMNDACPDMSSICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKKKIAVN 1941
            K  YKAFDEV+GIEVAW  VSIEDV+Q P QLERLYSEVHLLK+LKH+NI+K   SWVD+KNKTINMITELFTSGSLR YRKKH+ VD KAIKNWAR IL+GL+YLHS NPP+IHRDLKCDN+FVNGN GE+KIGDLGLA V+QQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMCMLEMVTCEYPY+EC+N AQIY+KVTS IKP SL KV++PQV+QFIEKCL+PAS R TA EL KDPFLA D  K+ +  L                E  PMD+D N+         KSV+   +   S  +E  R  EN EFRLR E++ D T S+ LRIAD  G+ R +HF FYL+SDTA +IA EMVE+L L+ ++V VIA++ID  IM+L+                      +H N  SP    ED +  NQ T+ S     + Q        ++K   SA Y      + +DGN +           E   +A S  S +  D+C  MS+I +   LS+ D D  ++LK EL  I+ Q++Q            I+NAK++WI KK+ AVN
Sbjct:   41 KTVYKAFDEVDGIEVAWNLVSIEDVMQMPGQLERLYSEVHLLKALKHENIIKLFYSWVDEKNKTINMITELFTSGSLRVYRKKHRKVDPKAIKNWARQILKGLNYLHSQNPPVIHRDLKCDNIFVNGNTGEVKIGDLGLATVLQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYNECRNQAQIYKKVTSNIKPQSLGKVDDPQVRQFIEKCLLPASSRPTALELSKDPFLARDGGKDSA--LLASSSTSSKYVRPPQLEHLPMDVDHNE--------NKSVSSNEDYPWSQTIELQRIAENKEFRLRGERSDDVTASMVLRIADPSGKCRIVHFAFYLESDTATAIAEEMVEELHLTSQEVVVIADMIDDFIMQLL-----------------SDRTSSHHNQNSPRLTHEDHEAANQQTVNSKDEEAAGQ--------SMKSDISADYYFP--YSANDGNAA----------MEAGRDAESMSSYL--DSCSMMSTIYN---LSISDNDYPEDLKTELNLIESQFNQSFQDLLKLKEDAIENAKRKWITKKQKAVN 561          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLD-TNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKL 1401
            K  YKAFDEVEGIEVAW  +SIEDVLQ P QL+RLYSEVHLL SLKH NI+K   SWVDD NK+INMITELFTSGSL  YRKKH+ VD KAI NWAR IL+GLHYLHS  PP+IHRDLKCDN+FVNGN G++KIGDLGLA VMQQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMCMLEMVTCEYPY EC+N AQIY+KVTSGIKP SLSKV++PQVKQFIEKCL+PA  R TA ELLKD  LA D  K+ +  L+               E RPMD++   +   SI S  KS  E +    +E  R  E+ EF+L  E+  D   S+ LRIA + G+ R + F+F L +DTA ++ GEMVE+LDLS  +V+VIAE+ID+LIMKL
Sbjct:   28 KTVYKAFDEVEGIEVAWNLMSIEDVLQMPGQLDRLYSEVHLLNSLKHDNIIKLFYSWVDDHNKSINMITELFTSGSLTLYRKKHRKVDPKAIMNWARQILKGLHYLHSQTPPVIHRDLKCDNIFVNGNTGKVKIGDLGLAAVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYRECRNQAQIYKKVTSGIKPQSLSKVDDPQVKQFIEKCLLPAPSRPTALELLKDQLLAVDGAKDST--LTASSNTTFKPAMPPQCEYRPMDVEYKKNTSVSICSSAKSSQECALLQTMEVQRVAESTEFKLSGERRDDVAASMALRIAGSSGQARKVDFDFNLKTDTARAVTGEMVEELDLSSHEVTVIAEMIDELIMKL 414          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNL------------KERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAH----QNILSPLAYAEDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSS 1662
            K  YKAFDEV+GIEVAW QV I+DVLQSP  LERLYSEV LLKSLKH NI++F NSW+DDKNKT+N+ITELFTSGSLR YRKKH+ V+MKA+KNWAR IL GL YLH   PPIIHRDLKCDN+F+NGN+GE+KIGDLGLA VM+Q  A SVIGTPEFMAPELYDE YNEL DIYSFGMCMLEMVT +YPY ECKN AQIY+KV+SGIKPASLS+V++P+VKQFIEKCL+PAS RL+A ELL DPFL  + L              +                    +   +DLD  D    I     + ++ S S  +E  R    N F L+ E+N + +VSL LRI D  GRVRNIHF FY + DTA  ++ EMVEQL+L+ ++V+ IAELID L++ ++P WK               DH  H    QN  S    A+ Q  + T+  DT        + + SCN     S +    +C   + G   S
Sbjct:   40 KTVYKAFDEVDGIEVAWNQVRIDDVLQSPNCLERLYSEVRLLKSLKHNNIIRFYNSWIDDKNKTVNIITELFTSGSLRHYRKKHRKVNMKAVKNWARQILMGLRYLHGQEPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFDYPYCECKNSAQIYKKVSSGIKPASLSRVKDPEVKQFIEKCLLPASERLSAKELLLDPFLQLNGLTMNNPLPLPDIVMPKEGAFGDRCLMSEGPPTTRPSKTLSIDLD-EDSNLPI----VTFSDNSGSRCIEVRRAKRGNFFVLKGEENDEQSVSLILRIVDENGRVRNIHFLFYQEGDTASKVSSEMVEQLELTDQNVTFIAELIDILLVNMIPTWKTDVTV----------DHLIHSQLNQNSRSHHNEAKPQKQEETVFHDTCE------LVSHSCNSDCPRSDE-EDKQCVDATKGEDKS 508          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNL------------KERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAH----QNILSPLAYAEDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSS 1662
            K  YKAFDEV+GIEVAW QV I+DVLQSP  LERLYSEV LLKSLKH NI++F NSW+DDKNKT+N+ITELFTSGSLR YRKKH+ V+MKA+KNWAR IL GL YLH   PPIIHRDLKCDN+F+NGN+GE+KIGDLGLA VM+Q  A SVIGTPEFMAPELYDE YNEL DIYSFGMCMLEMVT +YPY ECKN AQIY+KV+SGIKPASLS+V++P+VKQFIEKCL+PAS RL+A ELL DPFL  + L              +                    +   +DLD  D    I     + ++ S S  +E  R    N F L+ E+N + +VSL LRI D  GRVRNIHF FY + DTA  ++ EMVEQL+L+ ++V+ IAELID L++ ++P WK               DH  H    QN  S    A+ Q  + T+  DT        + + SCN     S +    +C   + G   S
Sbjct:   40 KTVYKAFDEVDGIEVAWNQVRIDDVLQSPNCLERLYSEVRLLKSLKHNNIIRFYNSWIDDKNKTVNIITELFTSGSLRHYRKKHRKVNMKAVKNWARQILMGLRYLHGQEPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFDYPYCECKNSAQIYKKVSSGIKPASLSRVKDPEVKQFIEKCLLPASERLSAKELLLDPFLQLNGLTMNNPLPLPDIVMPKEGAFGDRCLMSEGPPTTRPSKTLSIDLD-EDSNLPI----VTFSDNSGSRCIEVRRAKRGNFFVLKGEENDEQSVSLILRIVDENGRVRNIHFLFYQEGDTASKVSSEMVEQLELTDQNVTFIAELIDILLVNMIPTWKTDVTV----------DHLIHSQLNQNSRSHHNEAKPQKQEETVFHDTCE------LVSHSCNSDCPRSDE-EDKQCVDATKGEDKS 508          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNL--------------KERS----CDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWK 1416
            K  +K FDEV+GIEVAW QV I+D+LQSP+ LERLYSEV LLKSLKH+NI++F NSW+DDKNKT+N+ITELFTSGSLRQYRKKH+ V+MKA+K WAR IL GL YLHS +PPIIHRD+KCDN+F+NGN+GE+KIGDLGLA VM+Q  A SVIGTPEFMAPELYDE YNEL DIYSFGMCMLEMVT EYPY EC+N AQIY+KV+SGIKPASLSKV++P+V +FIEKCL+PAS RL+A ELL D FL  + L              KE S    C +S                   M+LD ++    + S     +  S ++ +E  R    N F L+ E+N + +VSL LRI D  GRVRNIHF F+ + DTA +++ EMVEQL+L+ ++V  IAELID L++ L+P WK
Sbjct:   40 KTVFKGFDEVDGIEVAWNQVRIDDLLQSPDCLERLYSEVRLLKSLKHKNIIRFYNSWIDDKNKTVNIITELFTSGSLRQYRKKHRKVNMKAVKCWARQILTGLKYLHSQDPPIIHRDIKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFEYPYCECRNSAQIYKKVSSGIKPASLSKVKDPEVMKFIEKCLLPASERLSAEELLLDSFLNVNGLVMNNPLPLPDIVMPKEGSFGERCLMS-------EGPPNARNRTMSMNLDEDNNLPIVIS-----SNNSGTNCIEVRRAKRGNFFVLKGEENDENSVSLILRIVDENGRVRNIHFLFFQEGDTASNVSSEMVEQLELTDKNVKFIAELIDVLLVNLIPNWK 438          

Query:  247 YKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNL--------------KERS----CDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWK 1416
            +K FDEV+GIEVAW QV I+D+LQSP+ LERLYSEV LLKSLKH+NI++F NSW+DDKNKT+N+ITELFTSGSLRQYRKKH+ V+MKA+K WAR IL GL YLHS +PPIIHRD+KCDN+F+NGN+GE+KIGDLGLA VM+Q  A SVIGTPEFMAPELYDE YNEL DIYSFGMCMLEMVT EYPY EC+N AQIY+KV+SGIKPASLSKV++P+V +FIEKCL+PAS RL+A ELL D FL  + L              KE S    C +S                   M+LD ++    + S     +  S ++ +E  R    N F L+ E+N + +VSL LRI D  GRVRNIHF F+ + DTA +++ EMVEQL+L+ ++V  IAELID L++ L+P WK
Sbjct:   25 FKGFDEVDGIEVAWNQVRIDDLLQSPDCLERLYSEVRLLKSLKHKNIIRFYNSWIDDKNKTVNIITELFTSGSLRQYRKKHRKVNMKAVKCWARQILTGLKYLHSQDPPIIHRDIKCDNIFINGNHGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFEYPYCECRNSAQIYKKVSSGIKPASLSKVKDPEVMKFIEKCLLPASERLSAEELLLDSFLNVNGLVMNNPLPLPDIVMPKEGSFGERCLMS-------EGPPNARNRTMSMNLDEDNNLPIVIS-----SNNSGTNCIEVRRAKRGNFFVLKGEENDENSVSLILRIVDENGRVRNIHFLFFQEGDTASNVSSEMVEQLELTDKNVKFIAELIDVLLVNLIPNWK 420          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDN--LKERSCDLSXXXXXXXXXXXXXXXEAR-PMDLDTNDQKFSIG---SCRKSVN----------------------ETSNSSVLEFWRFTENN-----------EFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKP 1419
            K  Y+AFDE EGIEVAW QV + D LQSPE LERLY E+HLLK+LKH+NI+KF  SWVD  N+ IN +TELFTSG+LRQYR +HK V+++A+K+W R ILRGLHYLHSH+PP+IHRDLKCDN+FVNGN GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+E YNELVDIYSFGMC+LEMVT +YPYSEC +PAQIY+KV SG KP +L KV++P+VK FIEKCL   S+R++A ELL DPFL  D+     RS D+                    P +  + ++++S G   S   S+N                      ET  +  +E +    N+           +  ++ ++  D  + L LRIAD  GRVRNI+F F +++DTA+S+A EMV +LD+    V+ IA +ID  I  LVP W+P
Sbjct:   36 KTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTELFTSGTLRQYRLRHKRVNIRAMKHWCRQILRGLHYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFDYPYSECTHPAQIYKKVMSGKKPDALYKVKDPEVKCFIEKCLATVSLRVSARELLDDPFLRIDDGEFDLRSVDMEDSVGPLYRQPHHLPDYYNYPSNSSSLNRQYSNGNYPSNSSSLNRQYSNGYNSHHEYQNGWAYNPAETEETHGIELFESRNNDDQEEEKKSGNVDITIKGKRRDDGGLFLRLRIADKEGRVRNIYFPFDIETDTALSVATEMVAELDMDDHGVTKIANMIDGEISSLVPSWRP 468          

Query:  247 YKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDN--LKERSCDLSXXXXXXXXXXXXXXXEAR-PMDLDTNDQKFSIG---SCRKSVN----------------------ETSNSSVLEFWRFTENN-----------EFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKP 1419
            Y+AFDE EGIEVAW QV + D LQSPE LERLY E+HLLK+LKH+NI+KF  SWVD  N+ IN +TELFTSG+LRQYR +HK V+++A+K+W R ILRGLHYLHSH+PP+IHRDLKCDN+FVNGN GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+E YNELVDIYSFGMC+LEMVT +YPYSEC +PAQIY+KV SG KP +L KV++P+VK FIEKCL   S+R++A ELL DPFL  D+     RS D+                    P +  + ++++S G   S   S+N                      ET  +  +E +    N+           +  ++ ++  D  + L LRIAD  GRVRNI+F F +++DTA+S+A EMV +LD+    V+ IA +ID  I  LVP W+P
Sbjct:   16 YRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTELFTSGTLRQYRLRHKRVNIRAMKHWCRQILRGLHYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFDYPYSECTHPAQIYKKVMSGKKPDALYKVKDPEVKCFIEKCLATVSLRVSARELLDDPFLRIDDGEFDLRSVDMEDSVGPLYRQPHHLPDYYNYPSNSSSLNRQYSNGNYPSNSSSLNRQYSNGYNSHHEYQNGWAYNPAETEETHGIELFESRNNDDQEEEKKSGNVDITIKGKRRDDGGLFLRLRIADKEGRVRNIYFPFDIETDTALSVATEMVAELDMDDHGVTKIANMIDGEISSLVPSWRP 445          

Query:  247 YKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQP-TAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLS-HEDVSVIAELIDKLIMKLVPGWKP 1419
            Y+AFD++EGIEVAW QV ++D   S E L+RLYSEVHLLK+LKH++I+KF  SW+D ++ TIN+ITE+FTSG+LRQYRKKHK VD++A+K W+R IL GL YLHSH+PP+IHRDLKCDN+F+NGN GE+KIGDLGLA ++ +  +AHSVIGTPEFMAPELY+E+YN LVDIY+FGMC+LE+VT EYPYSEC N AQIYRKVTSGIKPA+L  V +PQV+ FIEKC+   S RL+A ELL DPFL     KE + ++S                                      N  + + +++    +E     +  ++    T+ L LRI D+ G++RNIHF F +++DT+ S+A EMVE+LDL+  +D+S IA++ID  I   +P W P
Sbjct:   37 YRAFDQLEGIEVAWNQVKLDDKFCSSEDLDRLYSEVHLLKTLKHKSIIKFYTSWIDHQHMTINLITEVFTSGNLRQYRKKHKCVDLRALKKWSRQILEGLVYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILHRARSAHSVIGTPEFMAPELYEEDYNVLVDIYAFGMCLLELVTFEYPYSECTNAAQIYRKVTSGIKPAALLNVTDPQVRAFIEKCIAKVSQRLSAKELLDDPFLKC--YKENTENVS----------------------------------SHKENGYNGNGIVDKLSDSEVGLLTVEGQRKDLNTIFLKLRITDSKGQIRNIHFPFNIETDTSFSVAIEMVEELDLTDDQDISTIAKMIDTEIHSHIPDWTP 393          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNET------SNSSVLEFWRFTENNE----FRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWK 1416
            K  Y+AFDE EGIEVAW QV + +  ++PE+LE+ + E+HLLK+L HQNI+KF  SWVD  N +IN +TELFTSG+LRQYR +H+ V+++A+K W + IL+GL YLHS +PPIIHRDLKCDN+F+NGN GE+KIGDLGLA ++++  A   +GTPEFMAPE+YDEEYNELVD+Y+FGMC+LEMVT +YPYSEC +PAQIY+KVTSG KP +   V++P+V++F+EKCL   + RLTA ELL+DPFL  DN+                         RP+D      +  +      +++        +S + E   F  ++E      ++ ++N D  + L LRI+D  GR+RNI+F F    DTA S+A EMV +LD++++DV+ IAE+ID  I  LVP WK
Sbjct:   36 KTVYRAFDEYEGIEVAWNQVKLRNFTRNPEELEKFFREIHLLKTLNHQNIMKFYTSWVDTNNLSINFVTELFTSGTLRQYRLRHRRVNIRAVKQWCKQILKGLLYLHSRSPPIIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAVRCVGTPEFMAPEVYDEEYNELVDVYAFGMCVLEMVTFDYPYSECTHPAQIYKKVTSGKKPEAFYLVKDPEVREFVEKCLANVTCRLTALELLQDPFLQDDNM--------------------DGFVMRPIDYYNGYDETGVFLRHPLIDDPLYHDQFESSQICEIDLFANDDEDHVDISIKGKRNGDDGIFLRLRISDAEGRIRNIYFPFETAIDTAWSVAVEMVSELDITNQDVAKIAEMIDAEIAALVPDWK 418          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGW--KPXXXXXXXXXXXXCGDHPAHQNILSPLAYAEDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMN----DACPDMSSICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKK 1926
            K  YKAFDEV+GIEVAW QV+IEDVLQS +QLERLYSEVHLLKSLKH+NI+KF +SWVDDKNKTIN+ITELFTSGS+RQYRKKHK VDMKAIKNWAR ILRGLHYLH+H+PPIIHRDLKCDN+FVNGN GE+KIGDLGLAIVMQQP A SVIGTPEFMAPELY+EEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIY+KV+SGIKPASL KV + QVK FIEKCLVPAS RL A ELLKDPFLAT+N KE                     E+  MD+D   +K S+GSC KS+NE+   S LE  RFTENNEFRLR  +N D TVSLTLRIAD CGR RNIHF FYLDSDTA+ IA EMVEQLDL  EDV+VIAELID LI KLVP W   P                   +    PL    D + + ++ SD    SA+Y +  AS +     +    S +CC  S+        +     K       S DS + +         MSSICS   LSL DKD   ELK EL +ID  Y+QC           I+NAKKR I KK
Sbjct:   36 KTVYKAFDEVDGIEVAWNQVNIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYSSWVDDKNKTINIITELFTSGSMRQYRKKHKTVDMKAIKNWARQILRGLHYLHTHSPPIIHRDLKCDNIFVNGNTGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVSSGIKPASLGKVSDHQVKVFIEKCLVPASTRLPAIELLKDPFLATENSKELVSSSLQLPNLISRQVHLLQSESHLMDIDC--KKLSVGSCTKSINESPQFSTLELSRFTENNEFRLRGAKNNDNTVSLTLRIADPCGRARNIHFTFYLDSDTAVLIAEEMVEQLDLLTEDVAVIAELIDNLIAKLVPSWNTSPSVRNGSSELENHSTSEAVKKPDFLPLTNMTDLETKQSVNSD---ISAEYNMAIASDS---GTNKSLGSSDCCLQSNMYDLEFGMLEDGISKHNKSTRNSNDSYIGSFSGMSRNASMSSICS---LSLADKDG-SELKQELDSIDSHYNQCLQELMKMREEAIENAKKRGITKK 592          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQNI----LSPLAYAEDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMNDACPDMSSICSLS---ELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEK 1923
            K  YKAFDEV+GIEVAW QV IEDVLQS +QLERLYSEVHLLKSLKH+NI+KF NSWVDDKNKTINMITEL TSG+LRQYRKKHK VDMKAIKNWAR ILRGL YLH+ +P IIHRDLKCDN+ VNGNNGE+KIGDLGLAIVMQQP A SVIGTPEFMAPELY+EEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIY+KVTSGIKPASL KV + QVK+FIEKCLVPAS+RL+A +LLKDPFLAT+N KE    LS               E+  MD+D   +  S+GSC KS+NE+     LE  RFTENNEFRLRAE+N D TVSLTLRIAD CGR RNIHF FYL+SDTA+SIA EMVEQLDLS EDV+VIAELID LI+KLVP W                +H   + +     SPL    D +   ++ SD    SA+Y +  A             SD     S G+ S   C +Q+             +V   D+C  MS   SLS    L L DKD   ELK EL +ID  Y+QC           I+NAK+RWI K
Sbjct:   36 KTVYKAFDEVDGIEVAWNQVDIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYNSWVDDKNKTINMITELLTSGNLRQYRKKHKTVDMKAIKNWARQILRGLQYLHTRSPRIIHRDLKCDNILVNGNNGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVTSGIKPASLGKVNDLQVKEFIEKCLVPASVRLSAIDLLKDPFLATENSKEVVSSLSQLPNVICKQVHLPQSESHHMDIDC--KMLSLGSCPKSINESPRFLTLELRRFTENNEFRLRAEKNDDNTVSLTLRIADPCGRARNIHFTFYLNSDTAVSIAEEMVEQLDLSSEDVAVIAELIDSLIVKLVPCWNTSSSVRNGSSELE--NHATSETVKTPDFSPLTNITDHEALQSVNSD---ISAEYNMAIA-------------SDASTNKSLGSSS---CSLQS-------------NVFHIDSCSVMSRNASLSIICSLFLADKDG-SELKLELDSIDSHYNQCFQELMKTREEAIENAKRRWISK 567          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATD-NLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQNILSPLAY--------------AEDQD-------------------------------------NQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDG---NGSSPDCMVQARL-KEKSYEAGSGDSVVMNDACPD--------------MSSICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKKKIAVN 1941
            K  Y+AFDEV+GIEVAW QV I+DVL+SPE  E+LYSEV+LL+SL+H+NI+KF NSWVDDKNKTINMITELFTSG+LRQYR+KH+N+D+KAIKNWAR ILRGL YLH H+PPIIHRDLKCDN+FVNGN+GE+KIGDLGLAIVMQ PTA SVIGTPEFMAPELY+EEYNELVDIYSFGMC+LE+VTC YPYSEC+N AQIY+KVTSGIKPASL  V N Q+K+FIEKCL+PAS RL+A ELLK PFL  +  + E+ CD                     MD+D ++++ S  +C  S N +  S VLE+ R  +NNEF L+  +N D + SLTLRI+D  GRVRNIHF FYLDSDTA+S+A EMVEQL+L+  DV+ IAELID LI+KL+PGWKP            C + P  +N    +AY              AE  D                                     N     S +S  S       +S N + SE   Y++D    G++G        D  +  +L ++ SY    G+ V MN++  +              MS   S S  SL DKD YD+LK  L AI+ QYH             ++  +KRW EKKK+A +
Sbjct:   32 KTVYRAFDEVDGIEVAWNQVRIDDVLRSPEDFEKLYSEVYLLRSLRHENIIKFSNSWVDDKNKTINMITELFTSGNLRQYRRKHRNIDIKAIKNWARQILRGLVYLHGHSPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQNPTAKSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCNYPYSECRNAAQIYKKVTSGIKPASLKTVGNTQIKEFIEKCLLPASERLSAKELLKHPFLQLEIPILEQICDPLPVPDQFPISLSLPKSGPLFMDMDIDEKQLSESTCTGSNNGSPKSPVLEYQRAHKNNEFGLKGMKNDDNSASLTLRISDLGGRVRNIHFIFYLDSDTAISVASEMVEQLELADHDVAFIAELIDSLIVKLLPGWKPSSYGSSNVAIGPCTESPVFENGEKSIAYPWNSMLSSVPVGTLAEQDDLSGLTRSHCLQADDSNISDSPNNEISQFVYNSSPSLANMGDQESQSSIVSEILVQGASSINSRTSE--YYNNDGSFKGTNGYVTESKLGDAYLNCKLDRQDSY---VGEFVSMNESTENSEWSFPKQSGASNVMSLTSSCSSQSLADKDGYDDLKLGLDAIEAQYHNWFVELTRMKEEALEATRKRWTEKKKLAAH 664          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERS---------CDLSXXXXXXXXXXXXXXXEARP--MDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCG-RVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKP 1419
            K  YKAFDEV GIEVAW QV I++VLQSP+ LERLYSE+HLLK+LK+ NIV+F NSW+DDK KT+N+ITELFTSGSLRQY KKH+ ++MKA+K WAR IL GL+YLH+H+PPIIHRDLKCDN+F+NGN GE+KIGDLGLA VM+Q  A SVIGTPEFMAPELYDE YNEL DIYSFGMCMLEMVT EYPYSEC+N AQIY+KV+SGIKPASLSKV++P +KQFIEKCL+PAS RL A ELL DPFL  +     S           ++                 +P  MDL  + +  +I S   SV+E ++S  LE  R    N F LR E N + +VSL LR+AD  G RVRNIHF FYLD DTA+S++ EMVEQL+L  E+V  IAELID L++KL+P WKP
Sbjct:   40 KTVYKAFDEVNGIEVAWNQVRIDEVLQSPDDLERLYSEMHLLKTLKNSNIVRFYNSWIDDKKKTVNIITELFTSGSLRQYCKKHRKIEMKAVKGWARQILNGLNYLHNHDPPIIHRDLKCDNIFINGNQGEVKIGDLGLATVMEQANAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFEYPYSECRNSAQIYKKVSSGIKPASLSKVKDPDLKQFIEKCLLPASERLPAKELLMDPFLDVNGFARNSSMSRSDILMSKMTAIGDRCLMSEGPATARNKPPSMDLSHDPEMPTITSFNNSVDEDTHSLCLEVRRAKRGNVFLLRGEGNDENSVSLILRMADQNGARVRNIHFLFYLDGDTALSVSSEMVEQLELEVENVKFIAELIDLLLLKLIPNWKP 445          

Query:  232 SVKCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADT-CGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWK 1416
            +VK  Y+AFDEV+G+EVAW Q ++EDV Q  +QLER  SE  LLKSLK++NI+KF + W+DD+ KT+NMITE+F SGSL QY KKHK+VD KAIKNWAR ILRGLHYLH+H PPII  +LKCD++FVNGNNGE+KIGDLGLAIV QQPT  S +GTP +MAPEL ++EYNELVD+YSFGMCMLEMVTCEYPY E KNP Q+Y+KV SG+KPASL+KV +PQVKQFIEKCLVPAS+RL A ELLKDPFLAT+N K+                      +    +D +D+K  +GSC++S++E    S LE  +FTE NEFRLR E+    T+SL L I +T C   R + F F+LDSDTA+S+A EMVEQL LS ED +  AELID L+MKLVP WK
Sbjct:   28 TVKTVYRAFDEVDGVEVAWKQANVEDVSQ--KQLERWTSEARLLKSLKNKNIIKFYDFWIDDEKKTLNMITEIFVSGSLSQYCKKHKDVDTKAIKNWARQILRGLHYLHNHEPPIILGNLKCDSIFVNGNNGEVKIGDLGLAIVTQQPTGSSDLGTPAYMAPELCEDEYNELVDVYSFGMCMLEMVTCEYPYCEIKNPGQVYKKVISGVKPASLNKVNDPQVKQFIEKCLVPASLRLPAIELLKDPFLATENSKDTVSGSMKLPNNLMPKQVINLPHSESRSMDIDDKKLLVGSCKESIDEKLQFSTLEICKFTEKNEFRLRGEKIDSNTISLNLNITETSCSLERKVEFPFHLDSDTAVSVAEEMVEQLGLSPEDAAYNAELIDILVMKLVPSWK 421          

Query:  235 VKCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAP-ELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADT-CGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWK 1416
            VK  Y+AFDEV+G+EVAW QV++E V  SP+QLERL +E  LLKSLK +NI+K  + W+DD+ KT+NMITE+F SGSL QY KKHK V+ KA+KNWAR ILRGLHYLH+H PPIIH DL+CDN+FVNGNNGE+KIGDLGLAIVMQ+PT    +GTP +MAP +L +EEYNELVD+YSFGMCMLEMVT EYP  ECKNP QIY+KV SG+KPASL KV +PQVKQFIEKCLVPAS+RL+A ELLKDPFLAT+N K+                        P +L    +K  +GSC++S+NE    S  E  +  E NEFRLR E+  + T+SLTL I +T C + R + F+FYLDSDTA+S+A EMVEQL+LS ED +  A+LID L+MKLVP  K
Sbjct:   27 VKTAYRAFDEVDGVEVAWKQVNVEHV--SPKQLERLTTEARLLKSLKDKNIIKIYDFWIDDEKKTLNMITEIFVSGSLSQYCKKHKGVNAKAVKNWARQILRGLHYLHTHEPPIIHGDLRCDNIFVNGNNGEVKIGDLGLAIVMQRPTGLCDLGTPAYMAPDQLCEEEYNELVDVYSFGMCMLEMVTREYPCCECKNPGQIYKKVISGVKPASLDKVNDPQVKQFIEKCLVPASLRLSAIELLKDPFLATENSKDTVSSSMKL----------------PNNLMPKQKKLLVGSCKESINEQLQFSTPEICKVNEKNEFRLRGEKIDNNTISLTLNITETSCCQSREVEFSFYLDSDTAVSVAEEMVEQLELSPEDAACSAKLIDALVMKLVPSLK 404          

Query:  247 YKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQP-TAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQNILSPLAYAEDQDNQATMISDTSACSAQYGVPTASCNV--KVSESAKYSSDECCTGSDGNGSSPDCMVQARL 1689
            Y+AFDE EGIEVAW QV + D+L++   LERLYSEVHLL +LKH+NI+KF NSW+D KN+ IN ITE+FTSG+LRQYR+KHK+V ++A+K W+R IL GL YLHSH+PP+IHRDLKCDN+FVNGN GE+KIGDLGLA ++QQ  +AHSVIGTPEFMAPELY+EEYNELVDIY+FGMC+LE+VT EYPY EC N AQIY+KVTSGIKPASL+KV++P VK FIEKC    S RL A ELL DPFL +D   E                       RP    +      I      VNE +  S  E  R     +F ++ ++    T+ L LRIAD+ G +RNIHF F ++ DTA+++A EMVE+LDL+ +DVS IA +ID  I   +PGW                   A  N+      AED +       D+S  S +  +P+    V  ++    KY SD   +  D +G+SP  + ++ L
Sbjct:   43 YRAFDEFEGIEVAWNQVKVADLLRNSVDLERLYSEVHLLNTLKHKNIIKFYNSWIDTKNENINFITEIFTSGTLRQYRQKHKHVGLRALKKWSRQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILQQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCLLELVTVEYPYVECTNAAQIYKKVTSGIKPASLAKVKDPAVKAFIEKCTAKVSDRLPAKELLMDPFLQSDEENE-----------------SVGHSFRPKAHSSGGSSDQI-----DVNEIAKDSSAEPIR-----DFTVQGQRKDINTIFLKLRIADSTGHIRNIHFPFDVEVDTAIAVASEMVEELDLTDQDVSTIAAMIDSEIRSHIPGW-------------------ASHNVSLENLVAEDSEPPFETKDDSSPLSNE-SIPSPGSLVLERLPSGRKYWSD---SPKDVDGNSPSKLGRSNL 476          

Query:  247 YKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQP-TAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLK-ERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQNILSPLAYAEDQDNQATMISDTSACSAQYGVPTASCNV-KVSESAKYSSDECCTGSDGNGSSP 1665
            Y+AFDE+EGIEVAW QV + D+L++   LERL+SEVHLLK+LKH+NI+KF NSWVD KN+ IN ITE+FTSG+LR+YR+KHK+VD++A+K W++ IL GL YLHSH+PP+IHRDLKCDN+FVNGN GE+KIGDLGLA ++QQ  +AHSVIGTPEFMAPELY+EEYNELVDIY+FGMC+LE+VT EYPY EC N AQIY+KVTSGIKPASL+KV++P VK FIEKC+   S RL A ELL DPFL +D       C L                      LD N+      S  +S                 + +F ++ ++    T+ L LRIAD+ G  RNIHF F +  DTA+++A EMVE+LD++ +DVS IA +ID  I   +P W                      N+      AED +  +    D+S  S +  +   S  + K+S   KY  D   +  D +G SP
Sbjct:   43 YRAFDELEGIEVAWNQVKVADLLRNSVDLERLFSEVHLLKTLKHKNIIKFYNSWVDTKNENINFITEIFTSGTLRKYRQKHKHVDLRALKKWSKQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILQQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCLLELVTVEYPYVECSNAAQIYKKVTSGIKPASLAKVKDPAVKAFIEKCIAKVSDRLPAKELLMDPFLRSDEENVSGGCSLRPKAHSSGGISD---------QLDVNESAKDKDSAAES-----------------SRDFSVQGQRKDINTIFLKLRIADSTGHFRNIHFPFDVKVDTAIAVASEMVEELDVTDQDVSTIAAMIDSEIRSHIPDWD-------------------SNNVSPENLAAEDSEPPSETKDDSSPLSNESSLSPGSLVLEKLSSGHKYWRD---SPKDVDGDSP 470          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNS----------SVLEFWRFTE----NNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKP 1419
            K  Y+AFDE EGIEVAW QV + D LQSPE LERLY E+HLLK+LKH+NI+KF  SWVD  N+ IN +TE+FTSG+LRQYR KHK V+++A+K+W R ILRGL YLHSH+PP+IHRDLKCDN+FVNGN GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+E YNELVDIYSFGMC+LEMVT EYPYSEC +P QIY+KV SG KP +L KV++P+V+ F+EKCL   S+RL+A ELL DPFL  D  +    DL                    ++   N+  +S G       E  N           S +E + + +    N +  ++ ++  D  + L LRIAD  GR+RNI+F F +++DTA+S+A EMV +LD++ +DV+ IA++ID  I  LVP W+P
Sbjct:   37 KIVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPVQIYKKVISGKKPDALYKVKDPEVRHFVEKCLATVSLRLSARELLNDPFLQIDGCES---DLRLLDHRIEVDGLGPLMRPPYLEHHDNNNSYSSGYLNGYDYEAQNEWEYHQVEVELSGIELFEYHDEHPANVDISIKGKRGDDGGIFLRLRIADKEGRIRNIYFPFDIENDTALSVATEMVAELDITDQDVTKIADMIDGEIASLVPEWRP 441          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNS----------SVLEFWRFTE----NNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWK 1416
            K  Y+AFDE EGIEVAW QV + D LQSPE LERLY E+HLLK+LKH+NI+KF  SWVD   + IN +TE+FTSG+LRQYR KH+ V+++A+K+W R ILRGL YLHSH+PP+IHRDLKCDN+FVNGN GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+E YNELVDIYSFGMC+LEMVT EYPYSEC +PAQIY+KV SG KP +L KV++P+V+QF+EKCL   S+RL+A ELL DPFL  D       DL                    ++L  N   +S G       E  N           + +E +   +    N +  ++ +   D  + L +RIAD  GR+RNI+F F +++DTA ++A EMV +LD++ +DV+ IA++ID  I  LVP WK
Sbjct:   29 KTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTAKRNINFVTEMFTSGTLRQYRLKHRRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVRQFVEKCLATVSLRLSAKELLNDPFLQIDGC---GSDLRPSEPGIEVHGLGPMMRLPYLELHDNTNSYSNGYLNGYGYEAQNEWEYHPVEVEPNGIELFEHHDEHPANVDISIKGKWGDDGGIFLRIRIADKEGRIRNIYFPFDIETDTASNVATEMVAELDINDQDVTKIADMIDGEIAALVPEWK 432          

Query:    1 MAESRIGLTMWSSVANRNSGTEFRDMWFIGCRFRLRSAVDSYSVACEAFSEHRLLLIPAGG---SQXXXXXXXXXXXXVCSVKCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQNILSPLAYAEDQDNQATMISDTSACSAQYGVPTAS--CNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMNDACPDMSSICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKKKIAVN 1941
            MAESRIGLTMWSSVANRNSGTEF DMWFIGCRFRLRSA D YSVACEAFSEH  L IP                         C YKAFDE EGIEVAWCQV+IE+VLQSPEQLERLYSEVHLLKSLKHQNIVKF NSWVDDKNKTIN+ITELFTSGSLRQYRKKHKNVDMKAIKNWAR ILRGLHYLHSHNPPIIHRDLKCDN+FVNGN GEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIY+KVTSG+KPASLSKV+NPQ+K+FIEKCLVPAS+RL+A ELLKDPFLATDNLKE +C  S               EA PMD+DTN QK S G CR+S NE SN SVLE   FTENNEFRL+AE+N+D TVSLTLRIADTCGRVRNIHF FYLDSDTA+SIAGEMVEQLDL HEDVSVIAELID LIMKLVPGWKP            C DH A QN+LS +A+AED+DNQ++MISDTS  SA++GVPTAS   NVKV ESAKYSSDECC  SDG  SSPDCMV+  +KEKSYEA SGDS VMN+AC DMSSICSLSELSL +KD Y ELKGEL AID+ Y +C           I++AKKRWIEKKKIAVN
Sbjct:  494 MAESRIGLTMWSSVANRNSGTEFGDMWFIGCRFRLRSAFDPYSVACEAFSEHCGLWIPVVVLLVEILLATMVALWRKIRLGNTCGYKAFDEEEGIEVAWCQVNIEEVLQSPEQLERLYSEVHLLKSLKHQNIVKFHNSWVDDKNKTINIITELFTSGSLRQYRKKHKNVDMKAIKNWARQILRGLHYLHSHNPPIIHRDLKCDNIFVNGNTGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVTSGVKPASLSKVDNPQIKEFIEKCLVPASMRLSAVELLKDPFLATDNLKEPNCIPS----QLEKLVNLPQPEACPMDVDTNYQKSSSGFCRRSTNEISNPSVLELQSFTENNEFRLKAEKNSDRTVSLTLRIADTCGRVRNIHFEFYLDSDTAISIAGEMVEQLDLPHEDVSVIAELIDNLIMKLVPGWKPSSEGSSCGTNSSCVDHAALQNVLSHVAHAEDRDNQSSMISDTSVTSAEHGVPTASGASNVKVMESAKYSSDECCKASDGYASSPDCMVKGVVKEKSYEADSGDSFVMNEACTDMSSICSLSELSLANKDGYGELKGELDAIDMHYRRCLVELLRSREEEIRSAKKRWIEKKKIAVN 1141          

Query:  502 MKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQNILSPLAYAEDQDNQATMISDTSACSAQYGVPTAS--CNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMNDACPDMSSICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKKKIAV 1938
            MKAIKNWAR ILRGLHYLHSHNPPIIHRDLKCDN+FVNGN GE KIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIY+KVTSG+KPASLSKV+NPQVKQFIEKCLVP S+RL+A ELLKDPFL TDNLKE +C                  EARPMD+DTN QK S+GSC +S NE SN SV E    TENNEFRLRA +  D TVSLTLRIADTCGRVRNIHF FYLDSDTA+S AGEMVEQLDL HEDVSVIAELID LIMKLVPGWKP            CGDHPA QN++S   +AED+DNQA+MI DTSA SA+Y VPT+S   NVKV +SAKYSSDECC GSDG G SPD +VQ  ++EKS EA S DSVVMN+A PDMSSI SLSELSL +K RY+ELKGEL AID QYH+C           IQ+A KRW+ KK ++V
Sbjct:    1 MKAIKNWARQILRGLHYLHSHNPPIIHRDLKCDNIFVNGNTGEXKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVTSGVKPASLSKVDNPQVKQFIEKCLVPXSMRLSAVELLKDPFLXTDNLKEPNC----VVLQSEKMVNLPQPEARPMDIDTNYQKSSVGSCARSTNENSNPSVXELQSLTENNEFRLRATKXADNTVSLTLRIADTCGRVRNIHFEFYLDSDTAISXAGEMVEQLDLLHEDVSVIAELIDNLIMKLVPGWKPSSEGSSCGTNSSCGDHPAPQNVVSHFVHAEDRDNQASMILDTSATSAEYXVPTSSGAXNVKVMKSAKYSSDECCKGSDGYGCSPD-IVQGAVREKSNEADSXDSVVMNEARPDMSSIWSLSELSLANKXRYNELKGELDAIDRQYHRCLLELLTLREEEIQSAXKRWMAKKILSV 476          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKP 1419
            K  YKAFDEVEG+EVAWCQV+I+ V    E++ERLYSEVHLLKSLKHQNIV+F NSWVDDKN TINMITELFTSGSLRQYR KHK VDMKAIKNWAR ILRGL YLHSHNPPIIHRDLKCDN+FVNG NGE+KIGDLGLAIVMQQPTAHS+IGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKN AQIY++VTSG+KPASLSKV+NPQ+KQFIEKCLVPAS+RL+A ELLKDP LATDNL E SCDLS                          + F++         TSNSSVLE   F++NNEFRLRA +N D TVSLTLRIADTCG VRNI F+FYLDSDT +SIA EMVEQLDLSHEDVSV+AEL D  I+KLVPGWKP
Sbjct:   34 KTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAIVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNLAQIYKRVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQL-----------------------QKLFTL------PEPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKP 394          

Query:    1 MAESRIGLTMWSSVANR-NSGTEFRDMWFIGCRFRLRSAVDSYSVACEAFSEHRLLLIPAGGSQXXXXXXXXXXXXVCSVKCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKP 1419
            MA+SRI LT  SS ANR NSGT+ + +       R    +DS    C    +  ++     G                + K  YKAFDEVEG+EVAWCQV+I+ V    E++ERLYSEVHLLKSLKHQNIV+F NSWVDDKN TINMITELFTSGSLRQYR KHK VDMKAIKNWAR ILRGL YLHSHNPPIIHRDLKCDN+FVNG NGE+KIGDLGLA VMQQPTAHS+IGTPEFMAPELYDEEYNELVDIYSFGMCMLEMV CEYPYSECKN AQIY+ VTSG+KPASLSKV+NPQ+KQFIEKCLVPAS+RL+A ELLKDP LATDNL E SCDLS                          + F++         TSNSSVLE   F++NNEFRLRA +N D TVSLTLRIADTCG VRNI F+FYLDSDT +SIA EMVEQLDLSHEDVSV+AEL D  I+KLVPGWKP
Sbjct:    1 MAKSRIVLTTGSSAANRRNSGTKEKIV-----PLRRFKVMDS----CSGLEDAGVVEKDPTGRYLRYDEVLGRG----AFKTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAXVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQL-----------------------QKLFTL------PEPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKP 428          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKP 1419
            K  YKAFDEVEG+EVAWCQV+I+ V    E++ERLYSEVHLLKSLKHQNIV+F NSWVDDKN TINMITELFTSGSLRQYR KHK VDMKAIKNWAR ILRGL YLHSHNPPIIHRDLKCDN+FVNG NGE+KIGDLGLA VMQQPTAHS+IGTPEFMAPELYDEEYNELVDIYSFGMCMLEMV CEYPYSECKN AQIY+ VTSG+KPASLSKV+NPQ+KQFIEKCLVPAS+RL+A ELLKDP LATDNL E SCDLS                          + F++         TSNSSVLE   F++NNEFRLRA +N D TVSLTLRIADTCG VRNI F+FYLDSDT +SIA EMVEQLDLSHEDVSV+AEL D  I+KLVPGWKP
Sbjct:   34 KTVYKAFDEVEGVEVAWCQVNIKGV----EEVERLYSEVHLLKSLKHQNIVQFHNSWVDDKNMTINMITELFTSGSLRQYRNKHKKVDMKAIKNWARQILRGLDYLHSHNPPIIHRDLKCDNLFVNGFNGELKIGDLGLAXVMQQPTAHSIIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVXCEYPYSECKNLAQIYKXVTSGVKPASLSKVDNPQIKQFIEKCLVPASMRLSAAELLKDPILATDNLNESSCDLSQL-----------------------QKLFTL------PEPTSNSSVLELXXFSKNNEFRLRAGKNPDNTVSLTLRIADTCGLVRNIRFDFYLDSDTVISIAWEMVEQLDLSHEDVSVVAELXDNSIVKLVPGWKP 394          

Query:  247 YKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQN 1482
            YKAFDEV+GIEVAW QV I+ VL+SPE LE+LYSEVHLLKS+KH NI+KF NSWVDD+  TINMITELFTSGSLR+YRKKHKNVDMKAI+NWAR IL GL +LHSHNPPIIHRDLKCDN+F+NGN GE+KIGDLGLA VMQQPTA SVIGTPEFMAPELY+EEYNELVD+YSFGMCMLEMVT EYPY ECK+PAQI++KVTSG+KPA+L K           KCLVPAS RL+A ELLKD FL  DN KE   D                     MD+DT+ ++ SI +C +S N   +  VLEF R  +NNEFRL   +N D +VSLTLRIAD CG+ RNIHF FY+ SDTA+S+A EMVEQL+L++ DV+ IAE ID LIMKL+PGWKP            CG  P ++N
Sbjct:   62 YKAFDEVDGIEVAWNQVKIDAVLRSPEDLEKLYSEVHLLKSVKHDNIIKFYNSWVDDQKNTINMITELFTSGSLRRYRKKHKNVDMKAIRNWARQILGGLVFLHSHNPPIIHRDLKCDNIFINGNLGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDVYSFGMCMLEMVTFEYPYCECKSPAQIFKKVTSGVKPAALGK-----------KCLVPASERLSAKELLKDAFLQVDNPKEPIRDPFQLPNQSLKATNLPKSGPLSMDIDTDYKQLSISTCAESNN--GSPQVLEFQRAHKNNEFRLSGIKNDDDSVSLTLRIADACGKARNIHFLFYIASDTAVSVASEMVEQLELTNHDVAFIAEFIDYLIMKLLPGWKPSIDYSSSGPTSLCGGSPVYRN 460          

Query:  244 RYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQP-TAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTN-DQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQNILSPLAYAEDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSG 1719
            RY+AFDE+EGIEVAW QV + D+L++ E LERLYSEVHLLK+LKH+NI+KF NSWVD K++ IN+ITE+FTSG+LRQYR+KHK+VD++A+K W+R IL GL YLH+H+PP+IHRDLKCDN+FVNGN GE+KIGDLGLA +++Q  +AHSVIGTPEFMAPELY+EEYNELVDIY+FGMC+LE+VT EYPY EC N AQI++KVTSG+KPASL+KV +P VK FIEKC+V  S RL A ELL DPFL +D+ +E                     +   +   ++ D   + GS  +   ET +           N +F ++  Q  D T+ L LRIAD+ G  RNIHF F +  DTA+++A EMV++LDL+ +DVS IAELID  I   +P W               GDH       +P ++A + +  A+ +      S+   +       ++    KY    C +  +G G+SP   V   L   +    +G
Sbjct:  415 RYRAFDELEGIEVAWNQVKVADLLRNSEDLERLYSEVHLLKTLKHKNIIKFYNSWVDAKHENINLITEIFTSGTLRQYRRKHKHVDLRALKKWSRQILEGLWYLHNHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLELVTFEYPYVECSNAAQIFKKVTSGVKPASLAKVTDPGVKAFIEKCIVKVSERLPAKELLMDPFLQSDDDRESITRSLRPTHYSGKVSFLSSAQRLFVSFSSHCDMLDAEGSSDQIDIETKDMDP----SHETNRDFSVQG-QRKDDTIFLKLRIADSTGHFRNIHFPFDIGEDTAIAVASEMVQELDLTDQDVSTIAELIDSEIHSHIPDW---------PIGENSGDH-IDGEASTPYSHASEYNEDASPLIHEDLLSSNLALE------RLPSGRKY---WCESPKEGGGNSPGKYVITNLNSPADPVTAG 884          

Query:  247 YKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQP-TAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQNILSPLAYAEDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSP 1665
            Y+AFDE+EG+EVAW QV + D+L++ E L RLYSEVHLLK+LKH+NI+KF NSWVD K++ IN+ITE+FTSG+LRQYR+KHK+VD++A+K W+R IL GL YLH+H+PP+IHRDLKCDN+FVNGN GE+KIGDLGLA +++Q  +AHSVIGTPEF APELY+EEYNELVDIY+FGMC+LE+VT EYPY EC N AQI++KVTSG+KPASL KV +P VK FIEKC+V  S RL A ELL DPFL +D+ +E     S                +   D++T D   S        +ETS              +F ++  Q  D T+ L LRIAD+ G  RNIHF F +  DTA+++A EMV++LDL+ +DVS +AE+ID  I   +P W               GDH       +P ++A +    A+ +   +  S    +       ++    KY    C +  +G G+SP
Sbjct:   43 YRAFDELEGLEVAWNQVKVADLLRNSEDLVRLYSEVHLLKTLKHKNIIKFYNSWVDAKHENINIITEIFTSGTLRQYRRKHKHVDLRALKKWSRQILEGLWYLHNHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQARSAHSVIGTPEFXAPELYEEEYNELVDIYAFGMCLLELVTFEYPYVECSNAAQIFKKVTSGVKPASLXKVTDPGVKAFIEKCIVKVSERLPAKELLMDPFLQSDDNRE-----SISRSLRPTHYSDAEGSSDQTDIETKDTDPS--------HETS-------------RDFSVQG-QRKDDTIFLKLRIADSTGHFRNIHFPFDIGEDTAIAVASEMVQELDLTDQDVSTLAEIIDSEIHSHIPDW---------PHGEDSGDH-IDGEASTPYSHASESKEDASPLIHEALLSNSLALE------RLPSGRKY---WCDSPKEGGGNSP 470          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSN-------SSVLEFWRFTENN-----EFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWK 1416
            K  Y+AFDE EGIEVAW QV + D LQSPE LERLY E+HLLK+LKH+NI+KF  SWVD  N+ IN +TE+FTSG+L+QYR KHK V+++A+KNW R ILRGL YLHSH+PP+IHRDLKCDN+F+NGN GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+E YNELVDIYSFGMC+LEMVT EYPYSEC +PAQIY+KV SG KP +L KV++P+V++F+EKCL  AS+RL+A ELL D FL  D   E   DL                    ++L  ++  FS G       +  N       S+ +E +   E++     +  ++ ++  D  + L LRI D  G VRNI+F F  ++DTA+S+A EMV +LD++ +D + IA +ID  I  LVP W+
Sbjct:  372 KIVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKNWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCVLEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVREFVEKCLATASLRLSARELLNDRFLQID---ECEYDLRSLDYGRHLDDMGPLARQPLLELHRSNSSFSNGYSNDYDXDAPNEWTVDIESTGIELFEHHEDDHSDDVDISIKGKRGEDGGIFLRLRITDKEGXVRNIYFPFDTENDTALSVATEMVAELDITDQDETRIANMIDGEISMLVPDWQ 773          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSN-------SSVLEFWRFTENN-----EFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWK 1416
            K  Y+AFDE EGIEVAW QV + D LQSPE LERLY E+HLLK+LKH+NI+KF  SWVD  N+ IN +TE+FTSG+L+QYR KHK V+++A+KNW R ILRGL YLHSH+PP+IHRDLKCDN+F+NGN GE+KIGDLGLA ++++  A   +GTPEFMAPE+Y+E YNELVDIYSFGMC+LEMVT EYPYSEC +PAQIY+KV SG KP +L KV++P+V++F+EKCL  AS+RL+A ELL D FL  D   E   DL                    ++L  ++  FS G       +  N       S+ +E +   E++     +  ++ ++  D  + L LRI D  G VRNI+F F  ++DTA+S+A EMV +LD++ +D + IA +ID  I  LVP W+
Sbjct:   36 KIVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDTANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKNWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCVLEMVTFEYPYSECTHPAQIYKKVVSGKKPDALYKVKDPEVREFVEKCLATASLRLSARELLNDRFLQID---ECEYDLRSLDYGRHLDDMGPLARQPLLELHRSNSSFSNGYSNDYDXDAPNEWTVDIESTGIELFEHHEDDHSDDVDISIKGKRGEDGGIFLRLRITDKEGXVRNIYFPFDTENDTALSVATEMVAELDITDQDETRIANMIDGEISMLVPDWQ 437          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKE------RSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQNILSPLAYAEDQ---------------------DNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMV--QARLKEKSYEAGSGDSVVMN-----------DACPDMS---SICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKKK 1929
            K  YKAFDEV+GIEVAW QV IED+LQSP+QLERLYSEVHLLKSLKH NI+KF NSWVDD NKTIN+ITELFTSGSLRQYRKKHKNVD+KAIKNWA+ ILRGLHYLHSHNPPIIHRDLKCDN+FVNGNNGE+KIGDLGLAIVMQQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMC+LE+VTCEYPY+ECKNPAQIY+KV+SGIKPASL KV +PQVKQFIEKCLVPAS+RL+A ELLKD F AT+N KE         D                 E +PMD+D N +K S+ +  KS++ T +   L+F RF +NN F+LR E+  D ++S+TL IAD CGR +NIHF FYLDSDTA+SIAGEMVEQLDL +EDV+VIAELID +I +LVP WKP            C D     N  + L +  D                      + Q+T+ S  S  S +     AS +    +S +   DEC   SD    + D  V    R KE  Y    G+ V MN           ++C  MS   S+ S+  LSL DKD  DELK E+  ID QYHQC           I+ AK RWI K +
Sbjct:   35 KTVYKAFDEVDGIEVAWGQVEIEDLLQSPQQLERLYSEVHLLKSLKHDNIIKFYNSWVDDTNKTINLITELFTSGSLRQYRKKHKNVDLKAIKNWAKQILRGLHYLHSHNPPIIHRDLKCDNIFVNGNNGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCEYPYNECKNPAQIYKKVSSGIKPASLGKVSDPQVKQFIEKCLVPASLRLSAQELLKDAFFATENSKEPVYNHMHVDDSLQSSNFMPNLMNLPKPELQPMDMDPNYKKLSVSTHMKSISGTPHFRALQFERFNKNNLFKLRGEKIDDNSISMTLHIADPCGRAKNIHFAFYLDSDTALSIAGEMVEQLDLYNEDVAVIAELIDVMISELVPTWKPAFESMLCGANSSCEDSLVLHNGGTSLRHPSDSGSAKGTSDAVTEHLISLSANGEEQSTVESALSGMSTKDDATVAS-DANDIKSLECPDDECYEASDRCCFNGDRQVLDHERHKEGRYNGNIGEPVAMNGFTKDWEISCIESCSGMSNSLSLSSICSLSLADKDPSDELKLEVDTIDTQYHQCFQELLRMREEAIEKAKNRWITKSR 640          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGW--KPXXXXXXXXXXXXCGDHPAHQNILSPLAYAEDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMN----DACPDMSSICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKK 1926
            K  YKAFDEV+GIEVAW QV+IEDVLQS +QLERLYSEVHLLKSLKH+NI+KF +SWVDDKNKTIN+ITELFTSGS+RQYRKKHK VDMKAIKNWAR ILRGLHYLH+H+PPIIHRDLKCDN+FVNGN GE+KIGDLGLAIVMQQP A SVIGTPEFMAPELY+EEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIY+KV+SGIKPASL KV + QVK FIEKCLVPAS RL A ELLKDPFLAT+N KE                     E+  MD+D   +K S+GSC KS+NE+   S LE  RFTENNEFRLR  +N D TVSLTLRIAD CGR RNIHF FYLDSDTA+ IA EMVEQLDL  EDV+VIAELID LI KLVP W   P                   +    PL    D + + ++ SD    SA+Y +  AS +     +    S +CC  S+        +     K       S DS + +         MSSICS   LSL DKD   ELK EL +ID  Y+QC           I+NAKKR I KK
Sbjct:   36 KTVYKAFDEVDGIEVAWNQVNIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYSSWVDDKNKTINIITELFTSGSMRQYRKKHKTVDMKAIKNWARQILRGLHYLHTHSPPIIHRDLKCDNIFVNGNTGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVSSGIKPASLGKVSDHQVKVFIEKCLVPASTRLPAIELLKDPFLATENSKELVSSSLQLPNLISRQVHLLQSESHLMDIDC--KKLSVGSCTKSINESPQFSTLELSRFTENNEFRLRGAKNNDNTVSLTLRIADPCGRARNIHFTFYLDSDTAVLIAEEMVEQLDLLTEDVAVIAELIDNLIAKLVPSWNTSPSVRNGSSELENHSTSEAVKKPDFLPLTNMTDLETKQSVNSD---ISAEYNMAIASDS---GTNKSLGSSDCCLQSNMYDLEFGMLEDGISKHNKSTRNSNDSYIGSFSGMSRNASMSSICS---LSLADKDG-SELKQELDSIDSHYNQCLQELMKMREEAIENAKKRGITKK 592          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVP-----GWKPXXXXXXXXXXXXCGDHPAHQNILSPLAYAEDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMNDACPDMSSICSLSE--LSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKKKI 1932
            K  YKAFDE+ GIEVAW QVS+EDVLQSP+QLERLYSEVHLLKSLKH+NI+KF NSWVDD NKTINMITELFTSGSLR+YRKKHKNVD+KAIKNWAR ILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGE+KIGDLGLA VMQQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMC+LEMVTCEYPYSECKNPAQIY+KVTSGIKPASL KV +P VK+FIEKC+VPAS+RL A ELLKDPFLAT+N KE                     E+ PMD+D+N +K S+GSC KS++E+ + S  EF R T  NEFRLR E+N D T+SLTLRI D CG V+NIHF FYLDSDT +SIA EMVEQLDLS+EDV++IAELID LI+KLVP     G                    A ++   PLA  + Q+ Q +++S+ S          AS N K   S+ Y+ D                        +YE GS D ++  D           SE  L     +  D+LK EL AID+QY+QC           I+NAKK+WI +KK+
Sbjct:   35 KTVYKAFDEINGIEVAWNQVSVEDVLQSPDQLERLYSEVHLLKSLKHENIMKFYNSWVDDNNKTINMITELFTSGSLRKYRKKHKNVDIKAIKNWARQILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEVKIGDLGLATVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILEMVTCEYPYSECKNPAQIYKKVTSGIKPASLCKVNDPLVKRFIEKCIVPASMRLPALELLKDPFLATENPKELVFASLHLPDLMLKQVSRGQSESYPMDIDSNHKKLSVGSCTKSMDESLHFSTSEFQRLTVKNEFRLRGEKNDDNTISLTLRIVDRCGGVKNIHFTFYLDSDTTLSIAEEMVEQLDLSNEDVAIIAELIDALILKLVPHLSQSGSTSSMPNGFSELHNDATFKVASKHDFLPLADLKGQETQDSLLSELSTELPLTVASDASTN-KPLGSSDYTID----------------------FNTYEFGS-DFMMHGDGTFKYGKYTKHSEKHLPSAKGEVQDDLKLELDAIDMQYNQCFRELSMMREEAIENAKKKWITRKKV 582          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQN----ILSPLAYAEDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMNDACPDMSSICSLS---ELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEK 1923
            K  YKAFDEV+GIEVAW QV IEDVLQS +QLERLYSEVHLLKSLKH+NI+KF NSWVDDKNKTINMITEL TSG+LRQYRKKHK VDMKAIKNWAR ILRGL YLH+ +P IIHRDLKCDN+ VNGNNGE+KIGDLGLAIVMQQP A SVIGTPEFMAPELY+EEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIY+KVTSGIKPASL KV + QVK+FIEKCLVPAS+RL+A +LLKDPFLAT+N KE    LS               E+  MD+D   +  S+GSC KS+NE+     LE  RFTENNEFRLRAE+N D TVSLTLRIAD CGR RNIHF FYL+SDTA+SIA EMVEQLDLS EDV+VIAELID LI+KLVP W                +H   +       SPL    D +   ++ SD    SA+Y +  A             SD     S G+ S   C +Q+             +V   D+C  MS   SLS    L L DKD   ELK EL +ID  Y+QC           I+NAK+RWI K
Sbjct:   36 KTVYKAFDEVDGIEVAWNQVDIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYNSWVDDKNKTINMITELLTSGNLRQYRKKHKTVDMKAIKNWARQILRGLQYLHTRSPRIIHRDLKCDNILVNGNNGEVKIGDLGLAIVMQQPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVTSGIKPASLVKVNDLQVKEFIEKCLVPASVRLSAIDLLKDPFLATENSKEVVSSLSQLPNVICKQVHLPQSESHHMDIDC--KMLSLGSCPKSINESPQFLTLELRRFTENNEFRLRAEKNDDNTVSLTLRIADPCGRARNIHFTFYLNSDTAVSIAEEMVEQLDLSSEDVAVIAELIDSLIVKLVPCWNTSSSVRNGSSELE--NHATSETGKTPDFSPLTNITDHEALQSVNSD---ISAEYNMAIA-------------SDASTNKSLGSSS---CSLQS-------------NVFHIDSCSGMSRNASLSIICSLFLADKDG-SELKLELDSIDSHYNQCFQELMKTREEAIENAKRRWISK 567          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSN-SSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQ----------------NILSPLAYA----EDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMNDACPDMSSICSLSELSL--VDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKKKIAV 1938
            K  YKAFDEV+GIEVAW Q+SIEDV+QSP+ LE+LYSEVHLLKSLKH+NI+K  +SWVD+K+  INMITELFTSGSLRQYRKKHKNVDMKAIKNWAR ILRGL +LHSHNPP+IHRDLKCDN+FVNGNNG++KIGDLGLAIVMQQPTA SVIGTPEFMAPELY+EEYNELVD+YSFGMC+LEM+TCEYPYSECKNPAQIY+KVTSGIKPASL++V +P+VKQFIEKCLVPAS+RL A+ELLKDPFLAT N KE   D                 E  PM++D+N +  S  S  +   ETS  SS  +  R TENNEFRLR E+N D T+SLTLRIAD  G  RNIHF FY+DSDT +SIA EMVE L+L  EDV+VIAELI  +I KLVP WKP                P ++                ++   L ++    EDQD Q ++ SD    SA+YG   A+ + K  E   +   ECC GS+G  ++PD  +    +E      S +SVV    C    ++  LS+ SL  +D+D  DEL+ E+ AI++QY Q            I+N KKRW  KK I+V
Sbjct:   32 KTVYKAFDEVDGIEVAWNQISIEDVMQSPQNLEKLYSEVHLLKSLKHENIIKMYSSWVDEKSSNINMITELFTSGSLRQYRKKHKNVDMKAIKNWARQILRGLCFLHSHNPPVIHRDLKCDNIFVNGNNGQVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDVYSFGMCILEMITCEYPYSECKNPAQIYKKVTSGIKPASLARVNDPEVKQFIEKCLVPASMRLPASELLKDPFLATGNTKEIYHDNLLLPNPPSKSLNPPTCEPHPMEIDSNVKHTSPASTVERDKETSQVSSNHDILRKTENNEFRLRGEKNADRTISLTLRIADANGGARNIHFPFYIDSDTTISIAEEMVEHLELKDEDVAVIAELIHNMIFKLVPDWKPLCENSSGTDNLYRPLEPQNEQLNCHWTLGSNNFDMKSMYEDLGHSQLDGEDQDKQESVSSD---ISAEYGTVIAT-DAKGVEQNCFILHECCKGSNGLNTNPDVRICG--QEDGNSNQSENSVV--SCCSPSENLDRLSKCSLTALDQDHLDELQLEIEAIEIQYQQSFRELMKMREEAIENVKKRWTSKKNISV 613          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQN-------------------ILSPLAYA-----EDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLK-EKSYEAGSGDSVVMNDACP----DMSSICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEK 1923
            K  YKAFDEV+GIEVAW  +S+EDV+Q+P+QLE+LYSE+HLLKSLKH N++K  NSWVDD   TINMITELFTSGSLRQYR KHKNVDMKAIKNWAR ILRGL +LH H+PPI+HRDLKCDN+FVNGN+G +KIGDLGLAIVMQQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMC+LEMVTCEYPYSEC NPAQIY+KVTSGIKPA+L+KV +P+VKQFIEKCLVPAS+RL+A+ELLKDPFLAT+N KE + D+                E  PM++D+  ++ S GS    + ETS  S  +  R TENN+F LR E+N ++T+SLTLRIA+ CG  RNIHF FY++SDTA+SIA EMVE L+L++EDVSVIAELI+ +I KLVP  KP                   QN                   +   L ++     +D + Q +++SD    S + G+  AS + KV E   +  DE   G D   S+ D     +    K+    S  S++ +  CP    D+SSICS   L+L DKD  + L+ E+ AID  + Q            I++ K+R  EK
Sbjct:   28 KTVYKAFDEVDGIEVAWNMISVEDVVQTPQQLEKLYSEIHLLKSLKHDNVIKLYNSWVDDTTGTINMITELFTSGSLRQYRNKHKNVDMKAIKNWARQILRGLCFLHCHSPPIVHRDLKCDNIFVNGNSGLVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILEMVTCEYPYSECNNPAQIYKKVTSGIKPAALAKVNDPEVKQFIEKCLVPASMRLSASELLKDPFLATENTKEINHDILELPNPHTKLVNPPTCEPHPMEIDSKSRRTSPGSSMGRIEETSQVSFFDLVRMTENNKFMLRGEKNAESTISLTLRIANACGGARNIHFPFYINSDTAISIAEEMVEHLELTNEDVSVIAELINDMIAKLVPNLKPLSEKLSSGTDQLYRPSSEVQNGEQFNCHWPLQSSDYDMKPVFKDLVHSWPVDGDDLEKQESVMSD---ISVECGITVAS-DSKVVEPDIFIFDEFWEGFDAFNSTSDVRFCGQEDGHKNQSENSSGSLINSCCCPFKNFDISSICS---LTLADKDPSEGLRLEIEAIDTYFEQRFRELEMMRVAAIESLKRRHGEK 611          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQN------------------------ILSPLAYAEDQDNQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMNDACP----DMSSICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKR 1911
            K  YKAFDEV+GIEVAW ++ +EDV+Q+P+QL +LYSEVHLLKSLKH N++K  NSWVDD   TINMITELFTSGSLRQYRKKHKNVDMKAIKNWAR ILRGL +LHS +PPI+HRDLKCDN+FVNGN+G +KIGDLGLAIVMQQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMC+LEMVTCEYPYSECKNPAQIY+KVTSGIKPA+L+KV +P+VKQFIEKCLVPAS+RL+A+ELLKDPFLAT+N KE + D                 E  PM++D+  ++ S GS    + ETS  S  +  R T+NN+  LR E+N ++T+SLTLRI D CG  RNIHF FY+DSDTA+SIA EMVE L+L++EDVSVIAELI+ +I KLVP  KP                   QN                        + S     +DQ+ Q +++SD SA     G+  AS + KV E   +  DE   G   N +S           K+    S  S++ +  CP    DMSSICS   L+L DKD  + L+ ++ AID  + +            I++AK+R
Sbjct:   28 KTVYKAFDEVDGIEVAWNRIGVEDVVQTPQQLGKLYSEVHLLKSLKHDNVIKLYNSWVDDTAGTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARQILRGLCFLHSQSPPIVHRDLKCDNIFVNGNSGLVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILEMVTCEYPYSECKNPAQIYKKVTSGIKPAALAKVNDPEVKQFIEKCLVPASMRLSASELLKDPFLATENTKEINHDTLQLPNPHIKLVNLPKCEPHPMEIDSYSRRTSPGSSMGRIEETSQVSFFDLVRMTDNNKLMLRGEKNAESTISLTLRIPDACGGARNIHFPFYMDSDTAISIAEEMVEHLELTNEDVSVIAELINDMIAKLVPNSKPLCEKLSSETNLLYRPSSEVQNGEQFNCHWPLQSSDYDMKAMYKDLVHSRPVDGDDQEKQESVMSDISAAC---GITIAS-DSKVVEPDIFIFDEFWEGF-FNSTSDIRFCGQEDGHKNQSENSVGSLINSCCCPFKNFDMSSICS---LTLADKDPSEGLRLDIEAIDTYFDRRFLELEMMRQEAIKSAKRR 605          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKP 1419
            K  YKAFDEV+GIEVAW QV IED+LQSP+QLERLYSEVHLLKSLKH NI+KF NSWVDD NKTIN+ITELFTSGSLRQYRKKHKNVD+KAIKNWA+ ILRGLHYLHSHNPPIIHRDLKCDN+FVNGNNGE+KIGDLGLAIVMQQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMC+LE+VTCEYPY+ECKNPAQIY+KV+SGIKPASL KV +PQVKQFIEKCLVPAS+RL+A ELLKD F AT+N KE                        P+ + T+    S+ +  KS++ T +   L+F RF +NN F+LR E+  D ++S+TL IAD CGR +NIHF FYLDSDTA+SIAGEMVEQLDL +EDV+VIAELID +I +LVP WKP
Sbjct:  174 KTVYKAFDEVDGIEVAWGQVEIEDLLQSPQQLERLYSEVHLLKSLKHDNIIKFYNSWVDDTNKTINLITELFTSGSLRQYRKKHKNVDLKAIKNWAKQILRGLHYLHSHNPPIIHRDLKCDNIFVNGNNGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCEYPYNECKNPAQIYKKVSSGIKPASLGKVSDPQVKQFIEKCLVPASLRLSAQELLKDAFFATENSKE------------------------PLSVSTHK---SMSTHMKSISGTPHFRALQFERFNKNNLFKLRGEKIDDNSISMTLHIADPCGRAKNIHFAFYLDSDTALSIAGEMVEQLDLYNEDVAVIAELIDVMISELVPTWKP 540          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSNSSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPA------HQNILS--------PLAYAEDQDNQA-----TMISDTSACSAQ---YGVPTASCNVKVSESAKYSSDECCT------GSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMNDACPDMSSICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKKKIAV 1938
            K  YKAFDEV+GIE+AW QV I+DVL+SPE LE+LYSEVHLLKSLKH+NI+KF NSWVDDK KT+NMITELFTSGSLRQYRKKHKNVDMKAIKNWAR +LRGL YLHSHNPPIIHRDLKCDN+FVNGN+GE+KIGDLGLAIVMQQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMCMLEMVT EYPY+ECKNPAQIY+KVTSGIKPASL KV + Q+K+FI KCL PAS RL A ELLKDPF  ++N KE                         MD+D +  + S  +  ++ N + +  VLEF R  +++EFRLRA++  D ++SLTLR  D+ G V+NIHF F LD+DT  S+ GEMVEQL+L+  +V+ IA+ ID +IM+L+PGWKP              + P       H   +S         LA AEDQD+ A     T+  D S  + +   +G      N K S     S  E             N SS +        +KS      D   +++     S  CS S LSL D D+   LK EL AID+QY              ++  KKRW+ KKK+AV
Sbjct:   34 KTVYKAFDEVDGIEIAWNQVKIDDVLRSPEDLEKLYSEVHLLKSLKHENIIKFYNSWVDDKKKTVNMITELFTSGSLRQYRKKHKNVDMKAIKNWARQVLRGLVYLHSHNPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYNECKNPAQIYKKVTSGIKPASLCKVTDLQIKEFIVKCLAPASERLPAKELLKDPFFQSENPKEPIRVPLQLPSRSPKSIILSKSGPFSMDIDPDHPQLSSSTSTEN-NGSPDFPVLEFQRMYKSSEFRLRAKKINDNSISLTLRTVDSYGPVKNIHFPFSLDTDTVHSVVGEMVEQLELAEHEVAFIADFIDYVIMRLLPGWKPPRDDPLGGARSPNAEPPVLGNGNNHDCTISHGDGNSSPNLANAEDQDSLASAGLVTLTVDASKKNDKTVGFGDYNIGGNYKGSNGGHASEQESRDPYHEDYKLQRNNSSIEEFTPMNKFQKSTVLSFDDLSGLSNV---RSLTCSCSSLSLADIDQDPGLKQELDAIDLQYQHWFQELSRMRVEALEATKKRWMTKKKLAV 624          

Query:  238 KCRYKAFDEVEGIEVAWCQVSIEDVLQSPEQLERLYSEVHLLKSLKHQNIVKFCNSWVDDKNKTINMITELFTSGSLRQYRKKHKNVDMKAIKNWARHILRGLHYLHSHNPPIIHRDLKCDNVFVNGNNGEIKIGDLGLAIVMQQPTAHSVIGTPEFMAPELYDEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYRKVTSGIKPASLSKVENPQVKQFIEKCLVPASIRLTATELLKDPFLATDNLKERSCDLSXXXXXXXXXXXXXXXEARPMDLDTNDQKFSIGSCRKSVNETSN---SSVLEFWRFTENNEFRLRAEQNTDTTVSLTLRIADTCGRVRNIHFNFYLDSDTAMSIAGEMVEQLDLSHEDVSVIAELIDKLIMKLVPGWKPXXXXXXXXXXXXCGDHPAHQNILSPLAYAEDQD--NQATMISDTSACSAQYGVPTASCNVKVSESAKYSSDECCTGSDGNGSSPDCMVQARLKEKSYEAGSGDSVVMNDACPDMSSICSLSELSLVDKDRYDELKGELVAIDVQYHQCXXXXXXXXXXXIQNAKKRWIEKKKIAVN 1941
            K  YKAFDEV+GIEVAW  VSIEDV+Q P QLERLYSEVHLLK+LKH+NI+K   SWVD+KNKTINMITELFTSGSLR YRKKH+ VD KAIKNWAR IL+GL+YLHS NPP+IHRDLKCDN+FVNGN GE+KIGDLGLA V+QQPTA SVIGTPEFMAPELY+EEYNELVDIYSFGMCMLEMVTCEYPY+EC+N AQIY+KVTS IKP SL KV++PQV+QFIEKCL+PAS R TA EL KDPFLA D  K+ +  L                E  PMD+D N+         KSV+   +   S  +E  R  EN EFRLR E++ D T S+ LRIAD  G+ R +HF FYL+SDTA +IA EMVE+L L+ ++V VIA++ID  IM+L+                      +H N  SP    ED +  NQ T+ S     + Q        ++K   SA Y      + +DGN +           E   +A S  S +  D+C  MS+I +   LS+ D D  ++LK EL  I+ Q++Q            I+NAK++WI KK+ AVN
Sbjct:   41 KTVYKAFDEVDGIEVAWNLVSIEDVMQMPGQLERLYSEVHLLKALKHENIIKLFYSWVDEKNKTINMITELFTSGSLRVYRKKHRKVDPKAIKNWARQILKGLNYLHSQNPPVIHRDLKCDNIFVNGNTGEVKIGDLGLATVLQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYNECRNQAQIYKKVTSNIKPQSLGKVDDPQVRQFIEKCLLPASSRPTALELSKDPFLARDGGKDSA--LLASSSTSSKYVRPPQLEHLPMDVDHNE--------NKSVSSNEDYPWSQTIELQRIAENKEFRLRGERSDDVTASMVLRIADPSGKCRIVHFAFYLESDTATAIAEEMVEELHLTSQEVVVIADMIDDFIMQLL-----------------SDRTSSHHNQNSPRLTHEDHEAANQQTVNSKDEEAAGQ--------SMKSDISADYYFP--YSANDGNAA----------MEAGRDAESMSSYL--DSCSMMSTIYN---LSISDNDYPEDLKTELNLIESQFNQSFQDLLKLKEDAIENAKRKWITKKQKAVN 561