ppa025482m, ppa025482m (mRNA) Prunus persica

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRE-LLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXL-PLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNY---XXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHCD-------------------LFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLIS------CFGKSHKS-RFCPSESRAANCYKHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTPG 1659
            FRE+LGKGAMKTVYKAFDE LGMEVAWNQVKL DVF SPD+LQRLYSEVHLLKNL+HDSI++++ SWID +  TFNFI+EMFTSGTLREYRQKY+RV+IGAVKNWARQIL GLAYLH  DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRGS HAHSVIGTPEFMAPELYEEEY+ELVD+Y+FGMCVLEMLTSEYPY ECSNPAQIYKKVTSGKLP AFY+IED+EA+ FVG+CLE+ +KRLPA ELL+DPFLA D  E +L   +I  Q   PN                         ++  D TIFLKV ISD+DG  +RNIYFPFDI +DT I VA EMV+ELEI+DWEP EIA+MIE+EI +L+P  K+  +P++   H+HSF Y               PFY           L   S  C+                   L INDDA               Y S TE+D   L            +HKS RFCP E  ++  +  CN     +RP++ N   CH  RKL RI+S +DVRSQLL RSL+E INKRRLFKT+GAVENIG+Q PG
Sbjct:   31 FREILGKGAMKTVYKAFDEFLGMEVAWNQVKLNDVFNSPDDLQRLYSEVHLLKNLDHDSIMRFHTSWIDLDGGTFNFISEMFTSGTLREYRQKYKRVDIGAVKNWARQILHGLAYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQHAHSVIGTPEFMAPELYEEEYDELVDVYSFGMCVLEMLTSEYPYCECSNPAQIYKKVTSGKLPEAFYRIEDVEAREFVGRCLEHVAKRLPAKELLMDPFLAVDHGEQMLPMLKISSQKPSPNGTVEKIPSFQTNPRKRSTDMTITGTINPDDYTIFLKVAISDKDGL-SRNIYFPFDIGSDTPIDVAAEMVRELEITDWEPFEIAKMIEEEIFALVPSWKQCTSPEN---HQHSFEYEEEEEEEDDDDETYHPFY-CYASESSRVALQDLSISCEIQSQHRNHMISGEDWFQEGLLINDDASSQSSLNSDKYSTLVYCSVTENDIDHLAPKRVEPIFTASTHKSTRFCPEEGTSS--WNQCNGS---RRPYDSN---CH--RKLSRIKSFVDVRSQLLRRSLMEMINKRRLFKTIGAVENIGYQEPG 599          

Query:    7 EMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXL---HAFSSHC--------DLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLISCF-------GKSHKS-RFCPSESRA------ANCYKHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            E+LGKGAMKTVYKA DEVLGMEVAWNQVKL +V  SPDELQRLYSEVHLL  LNHDSIIQ+Y SWID  R+TFNFITE FTSGTLREYR+KY+RV+I A+K WARQILRGL YLH  DPPVIHRDLKCDNIFVNGHLG+VKIGDLGLAA+LRGS  AHSVIGTPEFMAPELYEE YNELVD+Y+FGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLP AFY+I+DLEAQRF+GKCL  ASKRLPA ELLLDPFLASD+ + L  P++  Q    ND                       L+  DDTIFLKVQ +D+DG +ARNIYFPFDIV DT I VA EMVKELEI+DWEP EIA+MI+ EIS+L+P  KKW  PQ +H   ++F+Y             F            L   H   +          DLF  DD                YFSG E  H    S          K+ KS RFCP E+ +         YK        QR             +L R +SL+DVRSQLLHR+LVEE++KRRL KTVGAVENIGFQ P
Sbjct:   33 EVLGKGAMKTVYKAIDEVLGMEVAWNQVKLNEVLRSPDELQRLYSEVHLLSALNHDSIIQFYTSWIDVERKTFNFITEFFTSGTLREYRKKYKRVDIRAIKCWARQILRGLVYLHGHDPPVIHRDLKCDNIFVNGHLGEVKIGDLGLAAILRGSQSAHSVIGTPEFMAPELYEENYNELVDVYSFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPGAFYRIQDLEAQRFIGKCLVTASKRLPAKELLLDPFLASDEAKRLPKPKLGSQKPFLNDIRIEKLRLSDDRVRTNMTITG-TLNPDDDTIFLKVQTADKDG-SARNIYFPFDIVTDTPIDVAMEMVKELEITDWEPFEIADMIDGEISALVPQWKKWDMPQQHH---YAFDYQEEDEGHNHPFRSFSSCSSSQASFPCLSTSHRLDTMAQGGDWLKDDLF--DDTSSESSAHSGKYSNLNYFSGNE--HCSETSTLRREQHPGAKTQKSTRFCPEENSSTRKALPGKSYKQGKVLQESQRAPGSKDKFAMETIRLTRNRSLVDVRSQLLHRTLVEEVHKRRLSKTVGAVENIGFQAP 598          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDL-----GDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHK 1125
            + E+LGKGA KTVY+AFDE  G+EVAWNQVKL D   SP++L+RLY E+HLLK + H++I+++Y SW+D   R  NF+TEMFTSGTLR+YRQK++RVNI AVK+W RQILRGL YLH  DPPVIHRDLKCDNIFVNG+ G+VKIGDLGLAA+LR SH AH V GTPEFMAPE+YEEEYNELVDIY+FGMC+LEM+T EYPYSEC++PAQIYKKV SGK P+A YK++D E + FV KCL + S RL A ELL DPFL  DD E   +   P +     DD                    + + +      DD IFL+++I+D++  + RNIYFPFDI  DTA++VATEMV EL+I+D + ++IA+MI+ EI+SL+P  K
Sbjct:   27 YNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTMKHNNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRQKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVREFVEKCLASVSLRLSARELLQDPFLRIDDCE---SDLRPIECRREPDDMMEPTGIELFEYHEDEHPANVDISIKGKRREDDGIFLRLRIADKE-DHIRNIYFPFDIEMDTALSVATEMVAELDITDQDVTKIADMIDGEIASLVPEWK 401          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDD--------------RELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLD---LGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHK 1125
            + E+LGKGA KTVY+AFDE  G+EVAWNQVKL D   SP+EL+RLY E+HLLK L H++I+++Y SW+D   R  NF+TEMFTSGTLR+YR K++RVNI AVK+W RQILRGL YLH   PPVIHRDLKCDNIFVNG+ G+VKIGDLGLAA+LR SH AH V GTPEFMAPE+YEEEYNELVDIY+FGMC+LEM+T EYPYSEC++PAQIYKKV SGK P+A YK++D E ++FV KCL   + RL A ELL DPFL SDD               E+   PR+P   +   +                     + ++     D  IFL+++ISD++G+  RNIYFPFD+  DTA++VA EMV EL+I+D + ++IA+MI+ EI+SL+PG K
Sbjct:   26 YNEILGKGASKTVYRAFDEYEGIEVAWNQVKLNDFLQSPEELERLYCEIHLLKTLKHNNIMKFYTSWVDPANRNINFVTEMFTSGTLRQYRLKHRRVNIRAVKHWCRQILRGLLYLHNHKPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVRQFVEKCLATVTLRLSARELLKDPFLQSDDYGSDLRPIEYQRDLGEVGPLPRLPHYGIHHIEFERNEIDLFTYQEDEHLENVDISIEGRKRDDHGIFLRLRISDKEGR-VRNIYFPFDMETDTALSVAMEMVSELDITDQDVTKIADMIDDEIASLVPGWK 415          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRE-LLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGD-DTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLI 1113
            ++E+LGKGA K VY+AFDE+ G+EVAWNQVK+ D+  + +E +RLYSEVHLLK L H +II++Y+SW+D      NFITE+FTSGTLR+YR+K++ V++ A+K W+RQIL GL YLH  DPPVIHRDLKCDNIFVNG+ G+VKIGDLGLAA+LR +  AHSVIGTPEFMAPELYEEEYNELVDIYAFGMC+LE++T EYPY EC+N AQIYKKVTSG  P +  K++D   + F+ KC+ N S RL A ELL DPFL SD+    +     P  +   + D                    +     D +TIFLK++I+D  G + RNI+FPFDI  DTAI+VA EMV+EL+++D + S IA MI+ EI S+I
Sbjct:   30 YKEVLGKGAFKKVYRAFDELEGIEVAWNQVKVADLLRNSEEFERLYSEVHLLKTLKHKNIIKFYISWVDTRNENINFITEIFTSGTLRQYRKKHKHVDLRALKKWSRQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCLLELVTFEYPYVECANAAQIYKKVTSGIKPASLAKVKDPRVRAFIDKCIANVSDRLSAKELLRDPFLQSDEENGSVGRSLQPHPHHSGSHDHFNTGTSSKVSLPESSRDFKVQGQRRDVNTIFLKLRIADSKG-HIRNIHFPFDIGADTAISVAGEMVEELDLTDQDVSTIAAMIDSEIRSII 401          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDD-RELLSTPRIP------FQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQD 1146
            F+E+LGKGA KTVYKAFDEV G+E+AWNQVK+ DV  SP++L++LYSEVHLLK+L H++II++Y SW+D  ++T N ITE+FTSG+LR+YR+K++ V++ A+KNWARQ+LRGL YLH  +PP+IHRDLKCDNIFVNG+ G+VKIGDLGLA V++    A SVIGTPEFMAPELYEEEYNELVDIY+FGMC+LEM+T EYPY+EC NPAQIYKKVTSG  P +  K+ DL+ + F+ KCL  AS+RLPA ELL DPF  S++ +E +  P  P      FQ +  + +                        + D++I L ++  D  G   +NI+FPF +  DT  +V  EMV++LE+++ E + IA+ I+  I  L+PG   W  P+D
Sbjct:   32 FKEILGKGAFKTVYKAFDEVDGIEIAWNQVKIDDVLRSPEDLEKLYSEVHLLKSLKHENIIKFYNSWVDDKKKTVNMITELFTSGSLRQYRKKHKNVDMKAIKNWARQVLRGLVYLHSHNPPIIHRDLKCDNIFVNGNHGEVKIGDLGLAIVMQ-QPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTFEYPYNECKNPAQIYKKVTSGIKPASLCKVTDLQIKEFIVKCLAPASERLPAKELLKDPFFQSENPKEPIRVPLHPDFPVLEFQRMYKSSEFRLRAKK-----------------INDNSISLTLRTVDSYGP-VKNIHFPFSLDTDTVHSVVGEMVEQLELAEHEVAFIADFIDYVIMRLLPG---WKPPRD 398          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASD----DRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDD--TIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHK 1125
            F+++LGKGA KTVYKAFD+V G+EVAWNQV++ +V  SPDEL+RLYSEVHLLK+L H +II++Y SWID   +T N ITE+FTSG+LR+YR+K+++V++ AVK WARQIL GL YLH  +PP+IHRDLKCDNIF+NG+ G+VKIGDLGLA V++ + +A +VIGTPEFMAPELY+E YNEL DIY+FGMC+LEM+T EYPYSEC N AQIYKKV++G  P A  KI+DLE + F+ KCL  AS+RL A +LL DPF   D    +  L     +P    M N                      L    G+D  +I L ++I+D++G+  RNI+F F + +DTA++V++EMV++LE++D   + IAE+I+  +  LIP  K
Sbjct:   35 FKDILGKGAFKTVYKAFDQVDGIEVAWNQVRIDEVLQSPDELERLYSEVHLLKSLKHKNIIKFYNSWIDDGNKTVNIITELFTSGSLRQYRKKHKKVDMKAVKGWARQILMGLNYLHNHNPPIIHRDLKCDNIFINGNQGEVKIGDLGLATVMQQA-NARTVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTLEYPYSECRNSAQIYKKVSNGIKPAALSKIKDLEVKMFIEKCLVPASQRLSAKKLLNDPFFQVDGLTKNHPLQLPDILPIITSMDNSVDGGPYSLCMEVQRAKGGNFFLLKGEGNDENSISLILRIADQNGR-LRNIHFMFYLDSDTALSVSSEMVEQLELADQNVTFIAELIDLLLIMLIPTWK 413          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRE---LLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHK 1125
            + E LGKGA KTVYKAFDEV G+EVAW QV+++D+  SP +L+RLYSEVHLLK+L HD+II++Y SW+D   +T N ITE+FTSG+LR+YR+K++ V++ A+KNWA+QILRGL YLH  +PP+IHRDLKCDNIFVNG+ G+VKIGDLGLA V++    A SVIGTPEFMAPELYEEEYNELVDIY+FGMC+LE++T EYPY+EC NPAQIYKKV+SG  P +  K+ D + ++F+ KCL  AS RL A ELL D F A+++ +    +ST +    ++     +                       + D++I + + I+D  G+ A+NI+F F + +DTA+++A EMV++L++ + + + IAE+I+  IS L+P  K
Sbjct:  164 YNEFLGKGAFKTVYKAFDEVDGIEVAWGQVEIEDLLQSPQQLERLYSEVHLLKSLKHDNIIKFYNSWVDDTNKTINLITELFTSGSLRQYRKKHKNVDLKAIKNWAKQILRGLHYLHSHNPPIIHRDLKCDNIFVNGNNGEVKIGDLGLAIVMQ-QPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCILELVTCEYPYNECKNPAQIYKKVSSGIKPASLGKVSDPQVKQFIEKCLVPASLRLSAQELLKDAFFATENSKEPLSVSTHKSMSTHMKSISGTPHFRALQFERFNKNNLFKLRGEKIDDNSISMTLHIADPCGR-AKNIHFAFYLDSDTALSIAGEMVEQLDLYNEDVAVIAELIDVMISELVPTWK 539          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLA 774
            + ++LG GA+K VY+AFD+  G+EVAWNQV+L++       + RL+SEV LL  L ++SII  Y  W D    T NFITE+ TSG LR+YR++++ V+I A+K W+RQ+L+GL YLH  DP +IHRDL C NIF+NG++GQVKIGDLGLAA++  +H AHSV+GTPE+MAPELYEE+Y E+VDIY+FGMC+LEM+T E PYSEC N A+IYKKVTSG  P A  K+ D E + F+ KC+     R  A ELL DPF +
Sbjct:  558 YSDLLGHGAVKKVYRAFDQEEGIEVAWNQVQLRNFSEDKSMVDRLHSEVKLLSTLKNESIIVLYSVWKDNEHNTLNFITEVCTSGNLRDYRKRHRHVSIKALKKWSRQVLKGLEYLHTHDPCIIHRDLNCSNIFINGNIGQVKIGDLGLAAIVGKNHLAHSVLGTPEYMAPELYEEDYTEMVDIYSFGMCLLEMVTMEIPYSECDNIAKIYKKVTSGVGPLAMNKVSDPEVKFFIEKCIAQPRARPSASELLNDPFFS 815          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFL-ASDDREL 792
            + E+LG GA+K VY+AFD+  G+EVAWNQVKL+        + RL+SEV LLK L   +II  Y  W + +  T NFITE+ TSG LREYR+K++ V++ A+K W++QIL+GL YLH+ +P +IHRDL C N+F+NG++G+VKIGD GLAA +  SH AHSV+GTPEFMAPELYEE+Y ELVDIY+FGMC LEM+T E PYSEC N A+IYKKV SG  P A  K+ D E + F+ KCL     R  A ELL DPF    DD E+
Sbjct:   28 YNELLGCGAVKRVYRAFDQEEGIEVAWNQVKLRAFSDDKPMIDRLFSEVRLLKTLKDKNIIALYNVWRNEDHNTLNFITEVCTSGNLREYRKKHRHVSMKALKKWSKQILKGLDYLHRHEPCIIHRDLNCSNVFINGNVGKVKIGDFGLAATVGKSHVAHSVLGTPEFMAPELYEEDYTELVDIYSFGMCFLEMVTLEIPYSECDNIAKIYKKVISGARPRAMDKVRDPEVKAFIEKCLAKPRARPSASELLNDPFFHGIDDDEI 292          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPN-DDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNY--XXXXXXXXXXXXPFYXXXXXXXXXXXLHAF-----SSHCDLFINDDAXXXXXXXXXXXXXXXYFSGTEDDH----HDLISCFGKSHKS-RFCPSESRAANCYKHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTPG 1659
            FRE+LGKGAMKTVYKAFDEVLGMEVAWNQVKL DVF SP+ELQRLYSEVHLLKNLNHDSII++Y SWID +RR FNFITEMFTSGTLR YR+KYQRV+I A+KNW+RQILRGLA+LH  DPPVIHRDLKCDNIF+NGHLG VKIGDLGLAAVL+GS HAHSVIGTPEFMAPELYEE+Y+ELVDIY+FGMCVLEMLT EYPYSECSNPAQIYKKVTSGKLP AFY+IED+EAQ F+GKCL  ASKRLPA ELLLDPFLASD+ EL + P++P     P   +                      ++  DDTIFLKV+IS++DGQ  RNIYFPFDI+NDTAI VA EMVKELEI+DWEP EIA+MIE++ISSLIPG K+  + Q +H  +H F+Y              PF+           L AF     +  C+LFI+DDA               Y SG EDD+     ++   FGK HKS RFCP++S +A  YKH N++L        N      QRKL RI+S +DVR+QLLHRSL+EEINKRRLFKTVGAVENIG+  PG
Sbjct:   31 FREVLGKGAMKTVYKAFDEVLGMEVAWNQVKLHDVFRSPEELQRLYSEVHLLKNLNHDSIIKFYTSWIDIDRRAFNFITEMFTSGTLRAYRKKYQRVDIRAIKNWSRQILRGLAFLHGHDPPVIHRDLKCDNIFINGHLGHVKIGDLGLAAVLQGSQHAHSVIGTPEFMAPELYEEDYDELVDIYSFGMCVLEMLTFEYPYSECSNPAQIYKKVTSGKLPEAFYRIEDVEAQEFIGKCLATASKRLPARELLLDPFLASDEAELGTIPKVPSPWSSPKVTEEKIMPSLLADPTKATEMTVTGTMNPQDDTIFLKVKISEKDGQ-TRNIYFPFDIMNDTAIDVAMEMVKELEITDWEPFEIADMIEEQISSLIPGWKQCSSSQIHHP-QHCFSYEDDDDDDHNDGPRHPFFASSSHSSSQASLLAFNCSFQTKPCELFIDDDASSQSSLNSFKYSTLNYSSGNEDDYDASLREVPLGFGKIHKSTRFCPADSLSAKQYKHRNARLDSGGCCSSN-----PQRKLSRIRSQVDVRNQLLHRSLLEEINKRRLFKTVGAVENIGYHEPG 589          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNY-XXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSS----------------------HCDLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLIS-----CFGKSHKS-RFCPSESRAANCYKHCNSQLHHQRPHELNHPLC---HHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTPG 1659
            FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKL DV  S DEL RLYSEVHLLKNL H+SII++Y SWID +RRTFNFITEMFTSGTLREYR+KYQ V+I AVKNWARQIL+GLAYLH  DPPVIHRDLKCDNIF+NGHLGQVKIGDLGLAA+LRGS HA SVIGTPEFMAPELYEEEYNELVDIY+FGMCVLEM TSEYPYSECSNPAQIYKKVTSGKLP AFYKI+D EAQ+FVGKCLE+ASKRLPA ELLLDPFL+SD+ +LL   +IP Q    N                        ++  DDT+FLKVQISD+DG + RNIYFP+D +NDTAI VA EMVKELEI+DWE  +IAEMIE++I+SLIP  K+WG  Q     +HSFNY             PF+           L A SS                        +LF NDD                Y SG ED             F K+HKS RFCP++S        C+ Q H QR  +L    C     Q KL R +SL+DVRSQLLH+SL+E+I+KRRLFKTVGAVENIGF  PG
Sbjct:   33 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLNDVLSSADELHRLYSEVHLLKNLKHESIIKFYSSWIDIDRRTFNFITEMFTSGTLREYRKKYQHVDIRAVKNWARQILQGLAYLHGHDPPVIHRDLKCDNIFINGHLGQVKIGDLGLAAILRGSQHARSVIGTPEFMAPELYEEEYNELVDIYSFGMCVLEMFTSEYPYSECSNPAQIYKKVTSGKLPEAFYKIKDTEAQKFVGKCLESASKRLPARELLLDPFLSSDEGKLLPVTKIPIQRSSSNASEEIIPSLLADPTKDTEMTITGTMNPDDDTVFLKVQISDKDG-HTRNIYFPYDTMNDTAIDVAVEMVKELEITDWESLDIAEMIEEQIASLIPSSKEWGLFQ----QQHSFNYDDDDEYDNDGNHHPFHSFSSRSSSQASLLALSSPYENPHLHGGSNTNVTCSLDWLQGELFTNDDTSSQSSFNSIKYSNLNYCSGNEDSCETSTRGGEHLSFAKAHKSTRFCPADSNL------CSKQ-HKQRNAQLGSWECSSSSSQPKLSRHRSLVDVRSQLLHKSLLEQIHKRRLFKTVGAVENIGFHEPG 605          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRE-LLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXL-PLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNY---XXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHCD-------------------LFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLIS------CFGKSHKS-RFCPSESRAANCYKHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTPG 1659
            FRE+LGKGAMKTVYKAFDE LGMEVAWNQVKL DVF SPD+LQRLYSEVHLLKNL+HDSI++++ SWID +  TFNFI+EMFTSGTLREYRQKY+RV+IGAVKNWARQIL GLAYLH  DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRGS HAHSVIGTPEFMAPELYEEEY+ELVD+Y+FGMCVLEMLTSEYPY ECSNPAQIYKKVTSGKLP AFY+IED+EA+ FVG+CLE+ +KRLPA ELL+DPFLA D  E +L   +I  Q   PN                         ++  D TIFLKV ISD+DG  +RNIYFPFDI +DT I VA EMV+ELEI+DWEP EIA+MIE+EI +L+P  K+  +P++   H+HSF Y               PFY           L   S  C+                   L INDDA               Y S TE+D   L            +HKS RFCP E  ++  +  CN     +RP++ N   CH  RKL RI+S +DVRSQLL RSL+E INKRRLFKT+GAVENIG+Q PG
Sbjct:   31 FREILGKGAMKTVYKAFDEFLGMEVAWNQVKLNDVFNSPDDLQRLYSEVHLLKNLDHDSIMRFHTSWIDLDGGTFNFISEMFTSGTLREYRQKYKRVDIGAVKNWARQILHGLAYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQHAHSVIGTPEFMAPELYEEEYDELVDVYSFGMCVLEMLTSEYPYCECSNPAQIYKKVTSGKLPEAFYRIEDVEAREFVGRCLEHVAKRLPAKELLMDPFLAVDHGEQMLPMLKISSQKPSPNGTVEKIPSFQTNPRKRSTDMTITGTINPDDYTIFLKVAISDKDGL-SRNIYFPFDIGSDTPIDVAAEMVRELEITDWEPFEIAKMIEEEIFALVPSWKQCTSPEN---HQHSFEYEEEEEEEDDDDETYHPFY-CYASESSRVALQDLSISCEIQSQHRNHMISGEDWFQEGLLINDDASSQSSLNSDKYSTLVYCSVTENDIDHLAPKRVEPIFTASTHKSTRFCPEEGTSS--WNQCNGS---RRPYDSN---CH--RKLSRIKSFVDVRSQLLRRSLMEMINKRRLFKTIGAVENIGYQEPG 599          

Query:    7 EMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXL---HAFSSHC--------DLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLISCF-------GKSHKS-RFCPSESRA------ANCYKHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            E+LGKGAMKTVYKA DEVLGMEVAWNQVKL +V  SPDELQRLYSEVHLL  LNHDSIIQ+Y SWID  R+TFNFITE FTSGTLREYR+KY+RV+I A+K WARQILRGL YLH  DPPVIHRDLKCDNIFVNGHLG+VKIGDLGLAA+LRGS  AHSVIGTPEFMAPELYEE YNELVD+Y+FGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLP AFY+I+DLEAQRF+GKCL  ASKRLPA ELLLDPFLASD+ + L  P++  Q    ND                       L+  DDTIFLKVQ +D+DG +ARNIYFPFDIV DT I VA EMVKELEI+DWEP EIA+MI+ EIS+L+P  KKW  PQ +H   ++F+Y             F            L   H   +          DLF  DD                YFSG E  H    S          K+ KS RFCP E+ +         YK        QR             +L R +SL+DVRSQLLHR+LVEE++KRRL KTVGAVENIGFQ P
Sbjct:   33 EVLGKGAMKTVYKAIDEVLGMEVAWNQVKLNEVLRSPDELQRLYSEVHLLSALNHDSIIQFYTSWIDVERKTFNFITEFFTSGTLREYRKKYKRVDIRAIKCWARQILRGLVYLHGHDPPVIHRDLKCDNIFVNGHLGEVKIGDLGLAAILRGSQSAHSVIGTPEFMAPELYEENYNELVDVYSFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPGAFYRIQDLEAQRFIGKCLVTASKRLPAKELLLDPFLASDEAKRLPKPKLGSQKPFLNDIRIEKLRLSDDRVRTNMTITG-TLNPDDDTIFLKVQTADKDG-SARNIYFPFDIVTDTPIDVAMEMVKELEITDWEPFEIADMIDGEISALVPQWKKWDMPQQHH---YAFDYQEEDEGHNHPFRSFSSCSSSQASFPCLSTSHRLDTMAQGGDWLKDDLF--DDTSSESSAHSGKYSNLNYFSGNE--HCSETSTLRREQHPGAKTQKSTRFCPEENSSTRKALPGKSYKQGKVLQESQRAPGSKDKFAMETIRLTRNRSLVDVRSQLLHRTLVEEVHKRRLSKTVGAVENIGFQAP 598          

Query:    7 EMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHC---DLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLISCFGKSHK---------SRFCPSESR--------AANCYKHCNSQLHHQR-PHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            E+LGKGAMKTVYKA DEVLGMEVAWNQVKL +V  SP++LQRLYSEVHLL  LNHDSIIQ+Y SWID +R+TFNFITEMFTSGTLREYR+KY+RVNI A+KNWARQIL+GL YLH  DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRGS  AHSVIGTPEFMAPELYEEEYNELVD+Y+FGMCVLEMLTSEYPYSEC NPAQIYKKVTSGKLP AFY+++DLEAQ+F+GKCL  ASKRL A ELLLDPFLASD+ E     R   Q    ND                     L  +  DDTIFLKVQI+++DG + RNIYFPFDI+NDT++ VA EMVK+L+I DWEP EIAEMI+ EI SL+P  KKW  PQ   A+ H+FNY            PF+           L    +     DL   DD                Y S   DDH    S   +  K         +RFCP ++         A + YK+C   L  Q              R+L R +SL+D+RSQLLHRSLVEE+NKRRLFKTVG VEN+GFQ P
Sbjct:   33 EVLGKGAMKTVYKAIDEVLGMEVAWNQVKLNEVLRSPEDLQRLYSEVHLLSTLNHDSIIQFYTSWIDVHRKTFNFITEMFTSGTLREYRRKYKRVNIQAIKNWARQILQGLVYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQLAHSVIGTPEFMAPELYEEEYNELVDVYSFGMCVLEMLTSEYPYSECVNPAQIYKKVTSGKLPAAFYRVQDLEAQKFIGKCLVAASKRLSAKELLLDPFLASDEAESPPLSRSENQKPFLNDSEMKKLHLNDPPRTDMTITGKLKSE--DDTIFLKVQIANKDG-SLRNIYFPFDILNDTSMDVAMEMVKDLDIDDWEPFEIAEMIDGEICSLVPNWKKWDLPQ-IEAY-HTFNY----QEDDGLDHPFHSSSSCSSSQASLSGLMAQWVPDDLI--DDTSSESSSHSGSYSNLNYVS--SDDHKFNTSTTRRPDKHPMTRNQNSTRFCPRDNSSSYIGQAIARDAYKYCKVLLESQSGASSSKQKRVMDGRRLTRNRSLVDIRSQLLHRSLVEEVNKRRLFKTVGDVENVGFQAP 590          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHC---DLFINDDAXXXXXXXXXXXXXXXYFSGTEDDH-HDLISCFGKSH-------KSRFCPSESR--------AANCYKHCNSQLHHQ-RPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            F E+LGKGAMKTVYKA DE LG+EVAWN+VKL  V  SPD+LQRLYSEVHLL  LNHDSII++Y SWID  R+TFNFITEMFTSGTLREYR+KY RVNI A+K WARQIL G+ YLH  DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRGS  AHSVIGTPEFMAPELYEE YNELVD+Y+FGMCVLEMLTSEYPYSEC+NPAQIYKKVTSGKLP  F++I+DLEAQRF+GKCL  A+KRL A ELLLDPFLASD+ EL   PR   Q    ND                       L+  DDTIFLKVQI++ DG   RNI+FPFDI++DT I VA EMVKELEI DWEP EIA+MI+  IS+L+P  KKW  P  +    H+F+Y            PF+           L     H    DLF  DD                Y SG  D+H  DL S     H        +RFCP E+         A N Y HC   L  Q R            R+L R +SL+D+RSQLLHRSLVEE++KRRL KTVG VE++GFQ P
Sbjct:   33 FEEVLGKGAMKTVYKAIDEFLGIEVAWNRVKLNQVLCSPDDLQRLYSEVHLLSTLNHDSIIKFYTSWIDVRRKTFNFITEMFTSGTLREYRKKYTRVNIRAIKKWARQILEGIVYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQSAHSVIGTPEFMAPELYEENYNELVDVYSFGMCVLEMLTSEYPYSECTNPAQIYKKVTSGKLPAVFHRIQDLEAQRFIGKCLVTAAKRLSAKELLLDPFLASDEAELPHVPRFRKQKPFLNDREMEKLQLNDHPPRTDMTITG-KLNPEDDTIFLKVQIANEDG-TLRNIFFPFDILHDTPIDVAMEMVKELEIDDWEPFEIADMIDGAISALVPNWKKWDLP--HIESHHTFDY----QEDDGHDHPFHSSSSCSSSPASLSGLMPHLLQDDLF--DDTSSQSSSHSGSYSCLNYISG--DEHKFDLSSTRRDKHLITRTQNSTRFCPQENSNSNIGQALATNAYNHCKVLLESQTRASSSKSKRMMDSRRLTRNRSLVDIRSQLLHRSLVEEVHKRRLSKTVGDVEDVGFQKP 592          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDREL-LSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPL----DLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXLHAF-------SSH--------------CDLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLISCFGKSH----------KSRFCPSESRAANCY--KHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            FR++LGKGA+K VY+AFDEVLG EVAWNQVKL DVF SPD L RLYSEVHLLKNL HDSI+ ++ SWID + RTFNFITE+FTSGTLREYR+KYQRV+I AVKNWARQIL GL YLH  DPPVIHRDLKCDNIF+NGHLGQVKIGDLGLAA+LRGS HAHSVIGTPEFMAPELYEEEYNELVDIY+FGMC++E+ TSE+PYSECSNPAQIYKKVTSGKLP A+Y+I DLEAQ+FVGKC  N S+RL A ELLLDPFLA++  +  L +P +P +     + +A                  + +    +  +DT+FLKVQIS+++GQ  RNI+FPFD +NDTAI VA EMVKELEISD EP EIAEMIE+EIS+L+P  + WG+ +  +  +HSF+Y            PF+           L  F       SSH               +LF+NDDA                     +D HD     G  H           +RFCP E    + +  + CN ++   R        CH   +L RI+S +D+R Q   RSLVEEI+KRR+FKTVGA+ENIGFQ P
Sbjct:   26 FRDILGKGAVKVVYRAFDEVLGREVAWNQVKLGDVFHSPDLLPRLYSEVHLLKNLEHDSIMTFHDSWIDVHCRTFNFITELFTSGTLREYRKKYQRVDIRAVKNWARQILSGLEYLHSHDPPVIHRDLKCDNIFINGHLGQVKIGDLGLAAILRGSQHAHSVIGTPEFMAPELYEEEYNELVDIYSFGMCMIEIFTSEFPYSECSNPAQIYKKVTSGKLPEAYYRIHDLEAQKFVGKCSANVSERLSAKELLLDPFLATEQLDSPLPSPTLPKKQTPTLNFTALLAKELPPPKSNQTKDTHMTITGSTNEENDTVFLKVQISNKNGQK-RNIFFPFDTINDTAIDVAMEMVKELEISDLEPLEIAEMIEEEISALVPTWRDWGSAK--YQKQHSFSY--EEAYDMSNHHPFFSPTSRSSSHASLPVFGSSSYKNSSHHRENHYPFAQDWPQDELFMNDDASSQSSMNSFKCFNLNCCDPGNEDEHDPTLALGAEHLFYTPKGNEKYTRFCPREEVMESDFTKQFCNMRMDSHR--------CHGMHRLTRIRSFVDLRRQQQQRSLVEEIHKRRMFKTVGAIENIGFQDP 602          

Query:    7 EMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIG-TPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHCDLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLISCFGKSH-------KSRFCPSESR--------AANCYKHCNSQLHHQ-RPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            E+LG+GAMKTVYKA DE LG+EVAWNQ KL  V  SP++LQRLYSEVHLL+ LNHDSII++Y SWID   +TFNFITEMFTSGTLR+YRQKY RVNI A+K WARQIL G+ YLH  DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRGS  AHSVIG TPEFMAPELYEE YNELVD+Y+FGMCVLEMLT+EYPYSEC+NPAQIYKKVTSGKLP  FY+I+DLEAQRF+GKCLE ASKRLPA ELLLDPFLASD+ EL   PRI  Q    ND                       L+  DDTIFLKVQI++ DG   RNI+FPFDI++DT I VA EMVKELEI DWEP EIA+MI+  IS L+P  KKW  P  +   RH F+Y              Y            H      DLF  DD                Y SG E    DL +   + H        +RFCP E+         A N Y +C   L  + R            R+L R +SL+D+RSQLLHRSLVEE++KRRL KTVG VE++GFQ P
Sbjct:   34 EVLGRGAMKTVYKAIDEFLGIEVAWNQAKLSRVLCSPEDLQRLYSEVHLLRILNHDSIIKFYASWIDVRGKTFNFITEMFTSGTLRQYRQKYTRVNIRAIKKWARQILEGIEYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQSAHSVIGSTPEFMAPELYEENYNELVDVYSFGMCVLEMLTAEYPYSECTNPAQIYKKVTSGKLPAVFYRIQDLEAQRFIGKCLETASKRLPAKELLLDPFLASDEAELSRVPRIRNQKSFLNDREMEKLQLNDHPPRTDMIITG-KLN-RDDTIFLKVQIANEDG-TPRNIFFPFDILHDTPIDVAMEMVKELEIGDWEPFEIADMIDGAISDLVPNWKKWDLP--HTEPRHIFDYQEDDGHNHPFHSSSYSSSHSSLSGSTPHLLQD--DLF--DDTSSQSSSHSGSYSCLNYISGYE-HKLDLSTTRREKHLDTRTQNSTRFCPRENSNSNIGQVLATNAYNNCKVLLESKSRVSSSKSKRMMDSRRLTRNRSLVDIRSQLLHRSLVEEVHKRRLSKTVGDVEDVGFQAP 590          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHCDLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLISCFGKS---------HKSRFCPSE------SRAANCYKHCNSQLHHQRPHELNHPLCH-HQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            F E+LGKGAMKTVY+A DE+LGMEVAWNQ+KL D+  SP++++RLYSEVHLL  LNH SI+++Y SWID   RTFNFITEMFTSGTLR YR+KYQRV+I A+KNWARQIL GL YLH+ DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRGS  AHSVIGTPEFMAPELYEE YNELVD+Y+FGMC+LEMLT EYPYSEC NPAQIYKKVTSGK P AFYK++DL+AQRF+ KCLE ASKRL A EL++DPFL  ++ +  S   +  Q    ND  A                    L+  DDTI +KVQI+D+ G + RN+YFPFDIV DT   VA EMVKELEI+DW+P EIA MI+ EIS L+P  KKW   Q   A  H  +Y            PF            L       D+F  DD                YFS   DD +D ++   K          H SRFCP E      S A  CYK C   L  +R    +        R+L R +SL+D+RSQLLH++LVEE++KRRLFKTVGAVENIGFQ P
Sbjct:   31 FEEVLGKGAMKTVYRAIDELLGMEVAWNQIKLNDLLHSPEDMERLYSEVHLLSTLNHHSIMRFYTSWIDVEHRTFNFITEMFTSGTLRGYRKKYQRVDIRAIKNWARQILEGLVYLHEHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQRAHSVIGTPEFMAPELYEENYNELVDVYSFGMCMLEMLTGEYPYSECVNPAQIYKKVTSGKRPRAFYKVQDLDAQRFIRKCLEPASKRLSAKELMVDPFLVFNNVDGKSVTMMQLQKPFLNDKIAIEDLHLNEDAPRTNMTITGKLNPEDDTILIKVQIADKKG-DVRNVYFPFDIVTDTPTEVANEMVKELEITDWKPYEIANMIDGEISGLVPQWKKWN--QFESADYHVLSYKDDDNDHHN---PFRGFSSCSSSQVSLSG-----DMF--DDTSSQSSSHSANYSNFNYFS---DDENDPVTTSTKQSQPATAINHHTSRFCPGENSSTGQSLARMCYKQCKDMLELKRTSSTSKEKGKVDTRRLTRNKSLVDMRSQLLHKTLVEEVHKRRLFKTVGAVENIGFQQP 582          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWG--TPQDYHA---------HRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHCDLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLISCFGKS---------HKSRFCPSE------SRAANCYKHCNSQLHHQRPHELNHPLCH-HQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            F E+LGKGAMKTVY+A DE+LGMEVAWNQ+KL D+  SP++++RLYSEVHLL  LNH SI+++Y SWID   RTFNFITEMFTSGTLR YR+KYQRV+I A+KNWARQIL GL YLH+ DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRGS  AHSVIGTPEFMAPELYEE YNELVD+Y+FGMC+LEMLT EYPYSEC NPAQIYKKVTSGK P AFYK++DL+AQRF+ KCLE ASKRL A EL++DPFL  ++ +  S   +  Q    ND  A                    L+  DDTI +KVQI+D+ G + RN+YFPFDIV DT   VA EMVKELEI+DW+P EIA MI+ EIS L+P  KKW      DYH          H + F                             H    H D+F  DD                YFS   DD +D ++   K          H SRFCP E      S A  CYK C   L  +R    +        R+L R +SL+D+RSQLLH++LVEE++KRRLFKTVGAVENIGFQ P
Sbjct:   31 FEEVLGKGAMKTVYRAIDELLGMEVAWNQIKLNDLLHSPEDMERLYSEVHLLSTLNHHSIMRFYTSWIDVEHRTFNFITEMFTSGTLRGYRKKYQRVDIRAIKNWARQILEGLVYLHEHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQRAHSVIGTPEFMAPELYEENYNELVDVYSFGMCMLEMLTGEYPYSECVNPAQIYKKVTSGKRPRAFYKVQDLDAQRFIRKCLEPASKRLSAKELMVDPFLVFNNVDGKSVTMMQLQKPFLNDKIAIEDLHLNEDAPRTNMTITGKLNPEDDTILIKVQIADKKG-DVRNVYFPFDIVTDTPTEVANEMVKELEITDWKPYEIANMIDGEISGLVPQWKKWNQFESADYHVLSYKDDDNDHHNPFRGFSSCSSSQVSLSGLLSSQVIDTNTNGPHWL--HGDMF--DDTSSQSSSHSANYSNFNYFS---DDENDPVTTSTKQSQPATAINHHTSRFCPGENSSTGQSLARMCYKQCKDMLELKRTSSTSKEKGKVDTRRLTRNKSLVDMRSQLLHKTLVEEVHKRRLFKTVGAVENIGFQQP 601          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFL-ASDDRELLSTPRIP----FQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIP 1116
            FRE+LGKGAMKTVYKAFD+VLGMEVAWNQVKL +VF SP+ LQRLYSEVHLLKNLNH+SII+Y  SWID NRRTFNFITE+FTSGTLREYR+KYQ+V+I A+K+WARQIL GLAYLH  DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRGS +AHSVIGTPEFMAPELYEE+YNELVDIY+FGMCVLEMLT EYPYSEC+NPAQIYKKVTSGKLP++F+ I+  EAQRFVGKCLE  S+RLPA ELL DPFL A+D+R+L    R+P     QNL  N                        ++  D TIFL+VQI D DG + RNI FPF+I++DT + VA EMVKELEI+DW+P EIA MIE EIS L+P
Sbjct:   27 FREVLGKGAMKTVYKAFDQVLGMEVAWNQVKLNEVFRSPEPLQRLYSEVHLLKNLNHESIIRYCTSWIDVNRRTFNFITELFTSGTLREYRRKYQKVDIRAIKSWARQILNGLAYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQNAHSVIGTPEFMAPELYEEDYNELVDIYSFGMCVLEMLTGEYPYSECTNPAQIYKKVTSGKLPDSFHLIQHTEAQRFVGKCLETVSRRLPAKELLADPFLAATDERDLAPLFRLPQQLAIQNLAANGTVVEHLPSTTDPTRTTDMSITGKMNSEDHTIFLQVQILDGDG-HMRNIQFPFNILSDTPLEVALEMVKELEITDWDPLEIAAMIENEISLLVP 402          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLST-----PRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHK---KWGTPQDYHAHR-HSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHCDLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLISCFGKSHK-SRFCPSESR-----AANCYKHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            F E+LG+GAMKTVYKA DE LG+EVAW+QVKLK+V  S  +LQRLYSEVHLL  LNH SII++Y SWID +  T NFITE+FTSGTLR+Y+ KY R++I A+K+WARQIL GL YLH+ DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLA +LR  H AHS+IGTPEFMAPELYEE YNEL+D+Y+FGMC LEM+TSE+PYSEC++PAQIYKKV  GKLP AFY++ D+EAQRF+GKCL +ASKR+ A ELL DPFLASD+  ++ T     P+ PF N     ++                     L   D+ I L+VQI+  +G  A N++FPFDI+NDT+I VA EMVKELEI DWEP EIA+MI+  ISSL+   K      TP D+H HR  SF+               Y                      ++D+                Y +   D++        ++H  +RFCP ES       AN Y   +S          N  L    R L R +SL+DV+ QLLHRS  EE  KRRLFKTVG VE +GFQ+P
Sbjct:   21 FAEILGRGAMKTVYKAIDEKLGIEVAWSQVKLKEVLRSSVDLQRLYSEVHLLSTLNHKSIIRFYTSWIDVHNHTLNFITELFTSGTLRQYKNKYLRIDIRAIKSWARQILEGLVYLHEHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLARMLRDCHSAHSIIGTPEFMAPELYEENYNELIDVYSFGMCFLEMITSEFPYSECNHPAQIYKKVVGGKLPGAFYRVGDIEAQRFIGKCLVSASKRVSAKELLQDPFLASDESWMVYTSGAGNPK-PFLN-----ENEMDTLKLEDDELRTEMSIAGKLGAEDNKIDLEVQIAYDNGL-ANNVFFPFDIMNDTSIDVAKEMVKELEIIDWEPVEIAKMIDGAISSLVSDWKYEEDDETPHDHHRHRTDSFHSSSSHASSSQASLSNY----------MARGLQDWVQDDLHDETYSQSSSHSGSYSNLNYIA--VDEYSSQSPVMSRTHNMTRFCPEESSHLQSGQANAYAASSS---------TNRSLASDNRTLTRNRSLVDVQRQLLHRSPGEEARKRRLFKTVGDVETVGFQSP 559          

Query:    7 EMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLA----SDDRELL---STPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHCDL-FINDDAXXXXXXXXXXXXXXXYF-----SGTEDDHHD------LISCFGKSHKSRFCPSESR----AANCYKHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            E+LGKGAMKTVY+ FDE+ G+EVAWNQ  + DV  +PD L R+Y+EV LL +L HD+II ++ SW+  +RRTFNFITE+F+SGTLR YR +Y RV+  AV  WAR ILRGLAYLH     VIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRG   A SVIGTPEFMAPE+Y+E Y   VD+Y+FGMC+LEMLT+EYPYSEC NPAQIYKKVT+GKLP+AFY++ D +A+RF+G+CL +A+ R  A ELLLDPFL+     DD  ++   + P  P      N                        L+   DTIFLKVQI    G+N RNIYFPFD+ NDTA+ VATEMVKEL+I+D EP+EIA MIE+EI  L+PG+K+         H +S+              PFY             +  S C +   + +                Y+     S ++DD          +S      + + C + S     A+          H  RP +        +R++ R +S++D+RSQLLHR+LVEE+NKR  F TVGAV +IGF+ P
Sbjct:   39 EVLGKGAMKTVYRGFDELRGVEVAWNQATISDVLRTPDALHRMYAEVSLLADLRHDAIIAFHASWVHPSRRTFNFITELFSSGTLRSYRLRYPRVSRRAVAAWARAILRGLAYLHARG--VIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGCASARSVIGTPEFMAPEMYDECYGVGVDVYSFGMCMLEMLTNEYPYSECDNPAQIYKKVTAGKLPDAFYRLTDADARRFIGRCLVDAAHRPSAEELLLDPFLSPSQNHDDHNIIAHATAPPPPLPLACSNSSEEQEEAAPAPAAKTTDMAITGKLNKEHDTIFLKVQIG--GGRNVRNIYFPFDVANDTAMEVATEMVKELDIADREPTEIAAMIEQEIVRLVPGYKQ---------HEYSYADDNDDDDVSGHPNPFY-----YLSSSPTSSQGSLCGVGSTSSEGFPGPHGKVDWSRDYCYYPPSSVSVSDDDDSSTSSLSAAVSASSLHQQQQHCSASSSRLGPASASASEDGGGGHAGRPRQREGEEERRRRRMSRNRSMVDMRSQLLHRTLVEELNKRLFFNTVGAVHDIGFRDP 593          

Query:    7 EMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLA----SDDRELL--STPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHCDLF-INDDAXXXXXXXXXXXXXXXYF-----SGTEDDHHDLISCFGK----SHKSRFCPSESR---AANCYKHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            E+LGKGAMKTVY+ FDE+ G+EVAWNQ  + DV  +PD L R+Y+EV LL +L HD+II ++ SW+  +RRTFNFITE+F+SGTLR YR +Y RV+  AV  WAR ILRGLAYLH     VIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRG   A SVIGTPEFMAPE+Y+E Y   VD+Y+FGMC+LEMLT+EYPYSEC NPAQIYKKVT+GKLP+AFY + D +A+RF+G+CL +A+ R  A ELLLDPFL+     DD   +  +T   P   L  ++ S                     L+   DTIFLKVQI    G N RNIYFPFD+ NDTA+ VATEMVKEL+I+D EP+EIA MIE+EI  L+PG+K+         H +S+              PFY             +  S C +   + +                Y+     S ++DD     S        S + + C + S     A+     +   H  RP +        +R++ R +S++D+RSQLLHR+LVEE+NKR  F TVGAV +IGF+ P
Sbjct:   39 EVLGKGAMKTVYRGFDELRGVEVAWNQATISDVLRTPDALHRMYAEVSLLADLRHDAIIAFHASWVHPSRRTFNFITELFSSGTLRSYRLRYPRVSRRAVAAWARAILRGLAYLHSRG--VIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGCTSARSVIGTPEFMAPEMYDECYGVGVDVYSFGMCMLEMLTNEYPYSECDNPAQIYKKVTAGKLPDAFYLLTDADARRFIGRCLVDAAHRPSAEELLLDPFLSPPQNHDDHNTIAHATAPPPPLPLACSNSSEEQEEEEAPAAKTTGMAITGKLNKEHDTIFLKVQIG--GGGNVRNIYFPFDVANDTAMEVATEMVKELDIADREPTEIAAMIEQEIVRLVPGYKQ---------HEYSYADDDDDDDVNGQPNPFY-----YLSSSPTSSQGSLCGVGPTSSEGFPGPHGKVDWSRDYCYYPPSSVSVSDDDDSSTSSLSAAVSAISLQQQHCSASSSRLGPASASASEDGGGHAGRPRQREGEEERRRRRMSRNRSMVDMRSQLLHRTLVEELNKRLFFNTVGAVHDIGFRDP 589          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASD---------DRELLSTPRIPF-------QNLMPN-------DDSAXXXXXXXXXXXXXXXXXXL-------PLDLGDDTI----------FLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIP 1116
            + ++LGKGA KTVY+AFDE  GMEVAWNQVKL D   SP++L+RLY E+HLLK L H +I+++Y SW+D +RR  NFITEMFTSGTLR+YRQK+ RVNI AVK+W RQIL GL YLH  DPP+IHRDLKCDNIFVNG+ G+VKIGDLGLAA+LR SH  H V GTPEFMAPE+YEEEYNELVDIY+FGMCVLEM+T EYPYSEC++P QIYKKV SG  P A YK++D   ++FV KCL  AS+RL A ELL DPFL  D         D  L++  R P+        ++M N       +D+                   L       PL   D TI          FL+++I+D DG + RNIYFPFDI  DTA++VATEMV EL+I+D E + IAEMI+ E+S+L+P
Sbjct:   29 YNDVLGKGASKTVYRAFDEYQGMEVAWNQVKLHDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDVSRRNINFITEMFTSGTLRQYRQKHMRVNIWAVKHWCRQILSGLLYLHSHDPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAVHCV-GTPEFMAPEVYEEEYNELVDIYSFGMCVLEMVTFEYPYSECTHPVQIYKKVISGTKPEALYKVKDPMVRQFVEKCLATASRRLSARELLKDPFLQVDDLVFCPGDGDYSLMNYLRQPYLEHAYSNVSMMSNGLSESIDEDTPTEDRWDCEDDDIKADGIDLFNGHEDEPLGNVDITIKGRKSEDGSIFLRLRIADNDG-HVRNIYFPFDIEADTALSVATEMVAELDITDHEVTRIAEMIDGEVSALVP 438          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASD---------DRELLSTPRIPF-------QNLMPN-------DDSAXXXXXXXXXXXXXXXXXXL-------PLDLGDDTI----------FLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIP 1116
            + ++LGKGA KTVY+AFDE  GMEVAWNQVKL D   SP++L+RLY E+HLLK L H +I+++Y SW+D +RR  NFITEMFTSGTLR+YRQK+ RVNI AVK+W RQIL GL YLH  DPP+IHRDLKCDNIFVNG+ G+VKIGDLGLAA+LR SH  H V GTPEFMAPE+YEEEYNELVDIY+FGMCVLEM+T EYPYSEC++P QIYKKV SG  P A YK++D   ++FV KCL  AS+RL A ELL DPFL  D         D  L++  R P+        ++M N       +D+                   L       PL   D TI          FL+++I+D DG + RNIYFPFDI  DTA++VATEMV EL+I+D E + IAEMI+ E+S+L+P
Sbjct:   29 YNDVLGKGASKTVYRAFDEYQGMEVAWNQVKLHDFLQSPEDLERLYCEIHLLKTLKHRNIMKFYTSWVDVSRRNINFITEMFTSGTLRQYRQKHMRVNIWAVKHWCRQILSGLLYLHSHDPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAVHCV-GTPEFMAPEVYEEEYNELVDIYSFGMCVLEMVTFEYPYSECTHPVQIYKKVISGTKPEALYKVKDPMVRQFVEKCLATASRRLSARELLKDPFLQVDDLVFCPGDGDYSLMNYLRQPYLEHAYSNVSMMSNGLSESIDEDTPTEDRWDCEDDDIKADGIDLFNGHEDEPLGNVDITIKGRKSEDGSIFLRLRIADNDG-HVRNIYFPFDIEADTALSVATEMVAELDITDHEVTRIAEMIDGEVSALVP 438          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQN--------------------------------LMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHK 1125
            + E+LGKGA KTVY+AFDE  G+EVAWNQVKL++   +P+EL++ + E+HLLK LNH +I+++Y SW+D N  + NF+TE+FTSGTLR+YR +++RVNI AVK W +QIL+GL YLH   PP+IHRDLKCDNIF+NG+ G+VKIGDLGLAA+LR S HA   +GTPEFMAPE+Y+EEYNELVD+YAFGMCVLEM+T +YPYSEC++PAQIYKKVTSGK P AFY ++D E + FV KCL N + RL A ELL DPFL  D+ +      I + N                                L  NDD                         GDD IFL+++ISD +G+  RNIYFPF+   DTA +VA EMV EL+I++ + ++IAEMI+ EI++L+P  K
Sbjct:   26 YDEILGKGASKTVYRAFDEYEGIEVAWNQVKLRNFTRNPEELEKFFREIHLLKTLNHQNIMKFYTSWVDTNNLSINFVTELFTSGTLRQYRLRHRRVNIRAVKQWCKQILKGLLYLHSRSPPIIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKS-HAVRCVGTPEFMAPEVYDEEYNELVDVYAFGMCVLEMVTFDYPYSECTHPAQIYKKVTSGKKPEAFYLVKDPEVREFVEKCLANVTCRLTALELLQDPFLQDDNMDGFVMRPIDYYNGYDETGVFLRHPLIDDPLYHDQFESSQICEIDLFANDDEDHVDISIKGKRN------------GDDGIFLRLRISDAEGR-IRNIYFPFETAIDTAWSVAVEMVSELDITNQDVAKIAEMIDAEIAALVPDWK 418          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLA--SDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEIS-DWEPSEIAEMIEKEISSLIP 1116
            ++E+LGKGA K VY+AFD++ G+EVAWNQVKL D F S ++L RLYSEVHLLK L H SII++Y SWID    T N ITE+FTSG LR+YR+K++ V++ A+K W+RQIL GL YLH  DPPVIHRDLKCDNIF+NG+ G+VKIGDLGLAA+L  +  AHSVIGTPEFMAPELYEE+YN LVDIYAFGMC+LE++T EYPYSEC+N AQIY+KVTSG  P A   + D + + F+ KC+   S+RL A ELL DPFL    ++ E +S+ +    N     D                       DL  +TIFLK++I+D  GQ  RNI+FPF+I  DT+ +VA EMV+EL+++ D + S IA+MI+ EI S IP
Sbjct:   24 YKEVLGKGAFKEVYRAFDQLEGIEVAWNQVKLDDKFCSSEDLDRLYSEVHLLKTLKHKSIIKFYTSWIDHQHMTINLITEVFTSGNLRQYRKKHKCVDLRALKKWSRQILEGLVYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILHRARSAHSVIGTPEFMAPELYEEDYNVLVDIYAFGMCLLELVTFEYPYSECTNAAQIYRKVTSGIKPAALLNVTDPQVRAFIEKCIAKVSQRLSAKELLDDPFLKCYKENTENVSSHKENGYNGNGIVDKLSDSEVGLLTVEGQRK------DL--NTIFLKLRITDSKGQ-IRNIHFPFNIETDTSFSVAIEMVEELDLTDDQDISTIAKMIDTEIHSHIP 389          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLG--------------------------DDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHK 1125
            + E+LG+GAMKTVYKAFDEV G+EVAW+QV++ +V  SPD L+RLYSEVHLLK+L H++++++Y  W+D  ++T N ITE+FTSG+LR+YRQK+ RV++ A+KNWARQ+LRGL YLH   PP+IHRDLKCDNIFVNG+ G+VKIGDLGLA V+  +  A SVIGTPEFMAPELY+E Y+ELVDIY+FGMC+LEM T EYPYSEC+N AQI+KKV+ G  P A  KI +++A++F+ KCL  AS+RL A ELL DPFL SD+  +L   + P       D S                      DLG                          D+++ L ++I+D  G +ARNI+F F + +DTA++VA EMV++LE++D + + IA+ I+  I +L+PG +
Sbjct:   27 YNEVLGRGAMKTVYKAFDEVEGIEVAWSQVEIDEVMQSPDNLERLYSEVHLLKSLKHENVMKFYNYWVDDQKKTINVITELFTSGSLRQYRQKHPRVDLKAIKNWARQVLRGLDYLHTHQPPIIHRDLKCDNIFVNGNHGEVKIGDLGLATVML-TPRAKSVIGTPEFMAPELYDENYDELVDIYSFGMCMLEMFTLEYPYSECTNAAQIFKKVSKGVKPAALAKITNIQAKQFIDKCLVPASERLSAKELLQDPFLCSDNSSVLVGTKFPSSLPKSVDVSLEALHMDVDTNESMCTSTCKRNDLGGPHRSVLEFTRTNKNTELKLTGEKLDDNSVSLVLRIADLCG-HARNIHFLFYLDSDTAMSVAAEMVEQLELADCDVTFIADFIDLLIVNLVPGQQ 425          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQ-------------------------------------NARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHK 1125
            ++E++GKGA KTVYKAFDEV G+EVAWNQV++ DV  SP+ L+RLYSEV LLK+L H++II++Y SWID   +T N ITE+FTSG+LR YR+K+++VN+ AVKNWARQIL GL YLH  +PP+IHRDLKCDNIF+NG+ G+VKIGDLGLA V+  + +A SVIGTPEFMAPELY+E YNEL DIY+FGMC+LEM+T +YPY EC N AQIYKKV+SG  P +  +++D E ++F+ KCL  AS+RL A ELLLDPFL  +   + +   +P   +MP + +                   L +DL +D+    V  SD  G                                        RNI+F F    DTA  V++EMV++LE++D   + IAE+I+  + ++IP  K
Sbjct:   30 YKEVIGKGAFKTVYKAFDEVDGIEVAWNQVRIDDVLQSPNCLERLYSEVRLLKSLKHNNIIRFYNSWIDDKNKTVNIITELFTSGSLRHYRKKHRKVNMKAVKNWARQILMGLRYLHGQEPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMEQA-NAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFDYPYCECKNSAQIYKKVSSGIKPASLSRVKDPEVKQFIEKCLLPASERLSAKELLLDPFLQLNGLTMNNPLPLP-DIVMPKEGAFGDRCLMSEGPPTTRPSKTLSIDLDEDSNLPIVTFSDNSGSRCIEVRRAKRGNFFVLKGEENDEQSVSLILRIVDENGRVRNIHFLFYQEGDTASKVSSEMVEQLELTDQNVTFIAELIDILLVNMIPTWK 439          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFL-ASDDRELLSTPRIP----FQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIP 1116
            FRE+LGKGAMKTVYKAFD+VLGMEVAWNQVKL +VF SP+ LQRLYSEVHLLKNLNH+SII+Y  SWID NRRTFNFITE+FTSGTLREYR+KYQ+V+I A+K+WARQIL GLAYLH  DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRGS +AHSVIGTPEFMAPELYEE+YNELVDIY+FGMCVLEMLT EYPYSEC+NPAQIYKKVTSGKLP++F+ I+  EAQRFVGKCLE  S+RLPA ELL DPFL A+D+R+L    R+P     QNL  N                        ++  D TIFL+VQI D DG + RNI FPF+I++DT + VA EMVKELEI+DW+P EIA MIE EIS L+P
Sbjct:   27 FREVLGKGAMKTVYKAFDQVLGMEVAWNQVKLNEVFRSPEPLQRLYSEVHLLKNLNHESIIRYCTSWIDVNRRTFNFITELFTSGTLREYRRKYQKVDIRAIKSWARQILNGLAYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQNAHSVIGTPEFMAPELYEEDYNELVDIYSFGMCVLEMLTGEYPYSECTNPAQIYKKVTSGKLPDSFHLIQHTEAQRFVGKCLETVSRRLPAKELLADPFLAATDERDLAPLFRLPQQLAIQNLAANGTVVEHLPSTTDPTRTTDMSITGKMNSEDHTIFLQVQILDGDG-HMRNIQFPFNILSDTPLEVALEMVKELEITDWDPLEIAAMIENEISLLVP 402          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFL-ASDDRELLSTPRIP----FQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIP 1116
            FRE+LGKGAMKTVYKAFD+VLGMEVAWNQVKL +VF SP+ LQRLYSEVHLLKNLNH+SII+Y  SWID NRRTFNFITE+FTSGTLREYR+KYQ+V+I A+K+WARQIL GLAYLH  DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRGS +AHSVIGTPEFMAPELYEE+YNELVDIY+FGMCVLEMLT EYPYSEC+NPAQIYKKVTSGKLP++F+ I+  EAQRFVGKCLE  S+RLPA ELL DPFL A+D+R+L    R+P     QNL  N                        ++  D TIFL+VQI D DG + RNI FPF+I++DT + VA EMVKELEI+DW+P EIA MIE EIS L+P
Sbjct:   27 FREVLGKGAMKTVYKAFDQVLGMEVAWNQVKLNEVFRSPEPLQRLYSEVHLLKNLNHESIIRYCTSWIDVNRRTFNFITELFTSGTLREYRRKYQKVDIRAIKSWARQILNGLAYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQNAHSVIGTPEFMAPELYEEDYNELVDIYSFGMCVLEMLTGEYPYSECTNPAQIYKKVTSGKLPDSFHLIQHTEAQRFVGKCLETVSRRLPAKELLADPFLAATDERDLAPLFRLPQQLAIQNLAANGTVVEHLPSTTDPTRTTDMSITGKMNSEDHTIFLQVQILDGDG-HMRNIQFPFNILSDTPLEVALEMVKELEITDWDPLEIAAMIENEISLLVP 402          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLST-----PRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHK---KWGTPQDYHAHR-HSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHCDLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLISCFGKSHK-SRFCPSESR-----AANCYKHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            F E+LG+GAMKTVYKA DE LG+EVAW+QVKLK+V  S  +LQRLYSEVHLL  LNH SII++Y SWID +  T NFITE+FTSGTLR+Y+ KY R++I A+K+WARQIL GL YLH+ DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLA +LR  H AHS+IGTPEFMAPELYEE YNEL+D+Y+FGMC LEM+TSE+PYSEC++PAQIYKKV  GKLP AFY++ D+EAQRF+GKCL +ASKR+ A ELL DPFLASD+  ++ T     P+ PF N     ++                     L   D+ I L+VQI+  +G  A N++FPFDI+NDT+I VA EMVKELEI DWEP EIA+MI+  ISSL+   K      TP D+H HR  SF+               Y                      ++D+                Y +   D++        ++H  +RFCP ES       AN Y   +S          N  L    R L R +SL+DV+ QLLHRS  EE  KRRLFKTVG VE +GFQ+P
Sbjct:   21 FAEILGRGAMKTVYKAIDEKLGIEVAWSQVKLKEVLRSSVDLQRLYSEVHLLSTLNHKSIIRFYTSWIDVHNHTLNFITELFTSGTLRQYKNKYLRIDIRAIKSWARQILEGLVYLHEHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLARMLRDCHSAHSIIGTPEFMAPELYEENYNELIDVYSFGMCFLEMITSEFPYSECNHPAQIYKKVVGGKLPGAFYRVGDIEAQRFIGKCLVSASKRVSAKELLQDPFLASDESWMVYTSGAGNPK-PFLN-----ENEMDTLKLEDDELRTEMSIAGKLGAEDNKIDLEVQIAYDNGL-ANNVFFPFDIMNDTSIDVAKEMVKELEIIDWEPVEIAKMIDGAISSLVSDWKYEEDDETPHDHHRHRTDSFHSSSSHASSSQASLSNY----------MARGLQDWVQDDLHDETYSQSSSHSGSYSNLNYIA--VDEYSSQSPVMSRTHNMTRFCPEESSHLQSGQANAYAASSS---------TNRSLASDNRTLTRNRSLVDVQRQLLHRSPGEEARKRRLFKTVGDVETVGFQSP 559          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQN--------------------------------LMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHK 1125
            + E+LGKGA KTVY+AFDE  G+EVAWNQVKL++   +P+EL++ + E+HLLK LNH +I+++Y SW+D N  + NF+TE+FTSGTLR+YR +++RVNI AVK W +QIL+GL YLH   PP+IHRDLKCDNIF+NG+ G+VKIGDLGLAA+LR S HA   +GTPEFMAPE+Y+EEYNELVD+YAFGMCVLEM+T +YPYSEC++PAQIYKKVTSGK P AFY ++D E + FV KCL N + RL A ELL DPFL  D+ +      I + N                                L  NDD                         GDD IFL+++ISD +G+  RNIYFPF+   DTA +VA EMV EL+I++ + ++IAEMI+ EI++L+P  K
Sbjct:   26 YDEILGKGASKTVYRAFDEYEGIEVAWNQVKLRNFTRNPEELEKFFREIHLLKTLNHQNIMKFYTSWVDTNNLSINFVTELFTSGTLRQYRLRHRRVNIRAVKQWCKQILKGLLYLHSRSPPIIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKS-HAVRCVGTPEFMAPEVYDEEYNELVDVYAFGMCVLEMVTFDYPYSECTHPAQIYKKVTSGKKPEAFYLVKDPEVREFVEKCLANVTCRLTALELLQDPFLQDDNMDGFVMRPIDYYNGYDETGVFLRHPLIDDPLYHDQFESSQICEIDLFANDDEDHVDISIKGKRN------------GDDGIFLRLRISDAEGR-IRNIYFPFETAIDTAWSVAVEMVSELDITNQDVAKIAEMIDAEIAALVPDWK 418          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLA--SDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEIS-DWEPSEIAEMIEKEISSLIP 1116
            ++E+LGKGA K VY+AFD++ G+EVAWNQVKL D F S ++L RLYSEVHLLK L H SII++Y SWID    T N ITE+FTSG LR+YR+K++ V++ A+K W+RQIL GL YLH  DPPVIHRDLKCDNIF+NG+ G+VKIGDLGLAA+L  +  AHSVIGTPEFMAPELYEE+YN LVDIYAFGMC+LE++T EYPYSEC+N AQIY+KVTSG  P A   + D + + F+ KC+   S+RL A ELL DPFL    ++ E +S+ +    N     D                       DL  +TIFLK++I+D  GQ  RNI+FPF+I  DT+ +VA EMV+EL+++ D + S IA+MI+ EI S IP
Sbjct:   24 YKEVLGKGAFKEVYRAFDQLEGIEVAWNQVKLDDKFCSSEDLDRLYSEVHLLKTLKHKSIIKFYTSWIDHQHMTINLITEVFTSGNLRQYRKKHKCVDLRALKKWSRQILEGLVYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILHRARSAHSVIGTPEFMAPELYEEDYNVLVDIYAFGMCLLELVTFEYPYSECTNAAQIYRKVTSGIKPAALLNVTDPQVRAFIEKCIAKVSQRLSAKELLDDPFLKCYKENTENVSSHKENGYNGNGIVDKLSDSEVGLLTVEGQRK------DL--NTIFLKLRITDSKGQ-IRNIHFPFNIETDTSFSVAIEMVEELDLTDDQDISTIAKMIDTEIHSHIP 389          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHS-------------------------------VIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQN--------------------------------LMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDG--------------------------QNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHK 1125
            + E+LGKGA KTVY+AFDE  G+EVAWNQVKL++   +P+EL++ + E+HLLK LNH +I+++Y SW+D N  + NF+TE+FTSGTLR+YR +++RVNI AVK W +QIL+GL YLH   PP+IHRDLKCDNIF+NG+ G+VKIGDLGLAA+LR SH                                   V GTPEFMAPE+Y+EEYNELVD+YAFGMCVLEM+T +YPYSEC++PAQIYKKVTSGK P AFY ++D E + FV KCL N + RL A ELL DPFL  D+ +      I + N                                L  NDD                         GDD IFL+++ISD +G                             RNIYFPF+   DTA +VA EMV EL+I++ + ++IAEMI+ EI++L+P  K
Sbjct:   26 YDEILGKGASKTVYRAFDEYEGIEVAWNQVKLRNFTRNPEELEKFFREIHLLKTLNHQNIMKFYTSWVDTNNLSINFVTELFTSGTLRQYRLRHRRVNIRAVKQWCKQILKGLLYLHSRSPPIIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAVRCVGTSKPSHHWNFIALIMFFTTLDLPLLCLCVVKGTPEFMAPEVYDEEYNELVDVYAFGMCVLEMVTFDYPYSECTHPAQIYKKVTSGKKPEAFYLVKDPEVREFVEKCLANVTCRLTALELLQDPFLQDDNMDGFVMRPIDYYNGYDETGVFLRHPLIDDPLYHDQFESSQICEIDLFANDDEDHVDISIKGKRN------------GDDGIFLRLRISDAEGIVSIFFDSFKIIGLKNVTRFRVLGNVGRIRNIYFPFETAIDTAWSVAVEMVSELDITNQDVAKIAEMIDAEIAALVPDWK 477          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQ-------------------------------------NARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHK 1125
            ++E++GKGA KTVYKAFDEV G+EVAWNQV++ DV  SP+ L+RLYSEV LLK+L H++II++Y SWID   +T N ITE+FTSG+LR YR+K+++VN+ AVKNWARQIL GL YLH  +PP+IHRDLKCDNIF+NG+ G+VKIGDLGLA V+  + +A SVIGTPEFMAPELY+E YNEL DIY+FGMC+LEM+T +YPY EC N AQIYKKV+SG  P +  +++D E ++F+ KCL  AS+RL A ELLLDPFL  +   + +   +P   +MP + +                   L +DL +D+    V  SD  G                                        RNI+F F    DTA  V++EMV++LE++D   + IAE+I+  + ++IP  K
Sbjct:   30 YKEVIGKGAFKTVYKAFDEVDGIEVAWNQVRIDDVLQSPNCLERLYSEVRLLKSLKHNNIIRFYNSWIDDKNKTVNIITELFTSGSLRHYRKKHRKVNMKAVKNWARQILMGLRYLHGQEPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMEQA-NAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFDYPYCECKNSAQIYKKVSSGIKPASLSRVKDPEVKQFIEKCLLPASERLSAKELLLDPFLQLNGLTMNNPLPLP-DIVMPKEGAFGDRCLMSEGPPTTRPSKTLSIDLDEDSNLPIVTFSDNSGSRCIEVRRAKRGNFFVLKGEENDEQSVSLILRIVDENGRVRNIHFLFYQEGDTASKVSSEMVEQLELTDQNVTFIAELIDILLVNMIPTWK 439          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQ-------------------------------------NARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHK 1125
            ++E++GKGA KTVYKAFDEV G+EVAWNQV++ DV  SP+ L+RLYSEV LLK+L H++II++Y SWID   +T N ITE+FTSG+LR YR+K+++VN+ AVKNWARQIL GL YLH  +PP+IHRDLKCDNIF+NG+ G+VKIGDLGLA V+  + +A SVIGTPEFMAPELY+E YNEL DIY+FGMC+LEM+T +YPY EC N AQIYKKV+SG  P +  +++D E ++F+ KCL  AS+RL A ELLLDPFL  +   + +   +P   +MP + +                   L +DL +D+    V  SD  G                                        RNI+F F    DTA  V++EMV++LE++D   + IAE+I+  + ++IP  K
Sbjct:   30 YKEVIGKGAFKTVYKAFDEVDGIEVAWNQVRIDDVLQSPNCLERLYSEVRLLKSLKHNNIIRFYNSWIDDKNKTVNIITELFTSGSLRHYRKKHRKVNMKAVKNWARQILMGLRYLHGQEPPIIHRDLKCDNIFINGNHGEVKIGDLGLATVMEQA-NAKSVIGTPEFMAPELYDENYNELADIYSFGMCMLEMVTFDYPYCECKNSAQIYKKVSSGIKPASLSRVKDPEVKQFIEKCLLPASERLSAKELLLDPFLQLNGLTMNNPLPLP-DIVMPKEGAFGDRCLMSEGPPTTRPSKTLSIDLDEDSNLPIVTFSDNSGSRCIEVRRAKRGNFFVLKGEENDEQSVSLILRIVDENGRVRNIHFLFYQEGDTASKVSSEMVEQLELTDQNVTFIAELIDILLVNMIPTWK 439          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRE 789
            + E+LGKGA KTVY+AFDE  G+EVAWNQVKL D   SP++L+RLY E+HLLK L H +I+++Y SW+D   R  NF+TE+FTSGTLR+YR +++RVNI A+K+W RQILRGL YLH  DPPVIHRDLKCDNIFVNG+ G+VKIGDLGLAA+LR SH AH V GTPEFMAPE+YEE YNELVDIY+FGMC+LEM+T +YPYSEC++PAQIYKKV SGK P+A YK++D E + F+ KCL   S R+ A ELL DPFL  DD E
Sbjct:   26 YNEVLGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTELFTSGTLRQYRLRHKRVNIRAMKHWCRQILRGLHYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFDYPYSECTHPAQIYKKVMSGKKPDALYKVKDPEVKCFIEKCLATVSLRVSARELLDDPFLRIDDGE 287          

Query:  919 DDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIP 1116
            D  +FL+++I+D++G+  RNIYFPFDI  DTA++VATEMV EL++ D   ++IA MI+ EISSL+P
Sbjct:  400 DGGLFLRLRIADKEGR-VRNIYFPFDIETDTALSVATEMVAELDMDDHGVTKIANMIDGEISSLVP 464          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASD---DRELLSTPRIPFQNLMP--------------------NDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLI----PGHKKWGTPQDYHAHRHSFN 1173
            + ++LG+GA KTVYKAFDEV G+EVAWN V ++DV   P +L+RLYSEVHLLK L H++II+ + SW+D   +T N ITE+FTSG+LR YR+K+++V+  A+KNWARQIL+GL YLH  +PPVIHRDLKCDNIFVNG+ G+VKIGDLGLA VL+    A SVIGTPEFMAPELYEEEYNELVDIY+FGMC+LEM+T EYPY+EC N AQIYKKVTS   P +  K++D + ++F+ KCL  AS R  A EL  DPFLA D   D  LL++     + + P                    N+D                          D T  + ++I+D  G+  R ++F F + +DTA A+A EMV+EL ++  E   IA+MI+  I  L+      H    +P+  H    + N
Sbjct:   31 YDDVLGRGAFKTVYKAFDEVDGIEVAWNLVSIEDVMQMPGQLERLYSEVHLLKALKHENIIKLFYSWVDEKNKTINMITELFTSGSLRVYRKKHRKVDPKAIKNWARQILKGLNYLHSQNPPVIHRDLKCDNIFVNGNTGEVKIGDLGLATVLQ-QPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYNECRNQAQIYKKVTSNIKPQSLGKVDDPQVRQFIEKCLLPASSRPTALELSKDPFLARDGGKDSALLASSSTSSKYVRPPQLEHLPMDVDHNENKSVSSNEDYPWSQTIELQRIAENKEFRLRGERSDDVTASMVLRIADPSGK-CRIVHFAFYLESDTATAIAEEMVEELHLTSQEVVVIADMIDDFIMQLLSDRTSSHHNQNSPRLTHEDHEAAN 446          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNY--XXXXXXXXXXXXPFYXXXXXXXXXXXLHAF---------------SSH----CDLFINDDAXXXXXXXXXXXXXXXYFSGTEDDH----HDLISCFGKSHKS-RFCPSESRAANCYKHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTPG 1659
            FRE+LGKGAMKTVYKAFDEVLGMEVAWNQVKL DVF SP+ELQRLYSEVHLLKNLNHDSII++Y SWID +RR FNFITEMFTSGTLR YR+KYQRV+I A+KNW+RQILRGLA+LH  DPPVIHRDLKCDNIF+NGHLG VKIGDLGLAAVL+GS HAHSVIGTPEFMAPELYEE+Y+ELVDIY+FGMCVLEMLT EYPYSECSNPAQIYKKVTSGKLP AFY+IED+EAQ F+GKCL  ASKRLPA ELLLDPFLASD+ EL S   I + NLM                                  FL  Q         RNIYFPFDI+NDTAI VA EMVKELEI+DWEP EIA+MIE++ISSLIPG K+  + Q +H  +H F+Y              PF+           L AF               S+H     +LFI+DDA               Y SG EDD+     ++   FGK HKS RFCP++S +A  YKH N++L        N      QRKL RI+S +DVR+QLLHRSL+EEINKRRLFKTVGAVENIG+  PG
Sbjct:   10 FREVLGKGAMKTVYKAFDEVLGMEVAWNQVKLHDVFRSPEELQRLYSEVHLLKNLNHDSIIKFYTSWIDIDRRAFNFITEMFTSGTLRAYRKKYQRVDIRAIKNWSRQILRGLAFLHGHDPPVIHRDLKCDNIFINGHLGHVKIGDLGLAAVLQGSQHAHSVIGTPEFMAPELYEEDYDELVDIYSFGMCVLEMLTFEYPYSECSNPAQIYKKVTSGKLPEAFYRIEDVEAQEFIGKCLATASKRLPARELLLDPFLASDEAELSSKSMI-YINLM----------------------------------FLVGQ--------TRNIYFPFDIMNDTAIDVAMEMVKELEITDWEPFEIADMIEEQISSLIPGWKQCSSSQIHHP-QHCFSYEDDDDDDHNDGPRHPFFASSSHSSSQASLLAFNCSFQTKPCQGRNMTSAHDWFEGELFIDDDASSQSSLNSFKYSTLNYSSGNEDDYDASLREVPLGFGKIHKSTRFCPADSLSAKQYKHRNARLDSGGCCSSN-----PQRKLSRIRSQVDVRNQLLHRSLLEEINKRRLFKTVGAVENIGYHEPG 539          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHC---DLFINDDAXXXXXXXXXXXXXXXYFSGTEDDH-HDLISCFGKSH-------KSRFCPSESR--------AANCYKHCNSQLHHQ-RPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            F E+LGKGAMKTVYKA DE LG+EVAWN+VKL  V  SPD+LQRLYSEVHLL  LNHDSII++Y SWID  R+TFNFITEMFTSGTLREYR+KY RVNI A+K WARQIL G+ YLH  DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRGS  AHSVIGTPEFMAPELYEE YNELVD+Y+FGMCVLEMLTSEYPYSEC+NPAQIYKKVTSGKLP  F++I DLEAQRF+GKCL  A+KRL A ELLLDPFLASD+ EL   PR   Q    ND                       L+  DDTIFLKVQI++ DG   RNI+FPFDI++DT I VA EMVKELEI DWEP EIA+MI+  IS+L+P  KKW  P  +    H+F+Y            PF+           L     H    DLF  DD                Y SG  D+H  DL S     H        +RFCP E+         A N Y HC   L  Q R            R+L R +SL+D+RSQLLHRSLVEE++KRRL KTVG VE++GFQ P
Sbjct:   33 FEEVLGKGAMKTVYKAIDEFLGIEVAWNRVKLNQVLCSPDDLQRLYSEVHLLSTLNHDSIIKFYTSWIDVRRKTFNFITEMFTSGTLREYRKKYTRVNIRAIKKWARQILEGIVYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQSAHSVIGTPEFMAPELYEENYNELVDVYSFGMCVLEMLTSEYPYSECTNPAQIYKKVTSGKLPAVFHRIPDLEAQRFIGKCLVTAAKRLSAKELLLDPFLASDEAELPHVPRFRKQKPFLNDREMEKLQLNDHPPRTDMTITG-KLNPEDDTIFLKVQIANEDG-TLRNIFFPFDILHDTPIDVAMEMVKELEIDDWEPFEIADMIDGAISALVPNWKKWDLP--HIESHHTFDY----QEDDGHDHPFHSSSSCSSSPASLSGLMPHLLQDDLF--DDTSSQSSSHSGSYSCLNYISG--DEHKFDLSSTRRDKHLITRTQNSTRFCPQENSNSNIGQALATNAYNHCKVLLESQTRASSSKSKRMMDSRRLTRNRSLVDIRSQLLHRSLVEEVHKRRLSKTVGDVEDVGFQKP 592          

Query:    7 EMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIG-TPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHCDLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHH-DLISCFGKSH-------KSRFCPSESR--------AANCYKHCNSQLHHQ-RPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            E+LG+GAMKTVYKA DE LG+EVAWNQ KL  V  SP++LQRLYSEVHLL+ LNHDSII++Y SWID   +TFNFITEMFTSGTLR+YRQKY RVNI A+K WARQIL G+ YLH  DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRGS  AHSVIG TPEFMAPELYEE YNELVD+Y+FGMCVLEMLT+EYPYSEC+NPAQIYKKVTSGKLP  FY+I+DLEAQRF+GKCLE ASKRLPA ELLLDPFLASD+ EL   PRI  Q    ND                       L+  DDTIFLKVQI++ DG   RNI+FPFDI++DT I VA EMVKELEI DWEP EIA+MI+  IS L+P  KKW  P  +   RH F+Y              Y            H      DLF  DD                Y SG  D+H  DL +   + H        +RFCP E+         A N Y +C   L  + R            R+L R +SL+D+RSQLLHRSLVEE++KRRL KTVG VE++GFQ P
Sbjct:   34 EVLGRGAMKTVYKAIDEFLGIEVAWNQAKLSRVLCSPEDLQRLYSEVHLLRILNHDSIIKFYASWIDVRGKTFNFITEMFTSGTLRQYRQKYTRVNIRAIKKWARQILEGIEYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQSAHSVIGSTPEFMAPELYEENYNELVDVYSFGMCVLEMLTAEYPYSECTNPAQIYKKVTSGKLPAVFYRIQDLEAQRFIGKCLETASKRLPAKELLLDPFLASDEAELSRVPRIRNQKSFLNDREMEKLQLNDHPPRTDMIITG-KLN-RDDTIFLKVQIANEDG-TPRNIFFPFDILHDTPIDVAMEMVKELEIGDWEPFEIADMIDGAISDLVPNWKKWDLP--HTEPRHIFDYQEDDGHNHPFHSSSYSSSHSSLSGSTPHLLQD--DLF--DDTSSQSSSHSGSYSCLNYISG--DEHKLDLSTTRREKHLDTRTQNSTRFCPRENSNSNIGQVLATNAYNNCKVLLESKSRVSSSKSKRMMDSRRLTRNRSLVDIRSQLLHRSLVEEVHKRRLSKTVGDVEDVGFQAP 590          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDD--------------RELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDL--------------------------GDD-TIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHK 1125
            + E+LGKGA KTVY+AFDE  G+EVAWNQVKL D   SP++L+RLY E+HLLK L H +I+++Y SW+D  +R  NF+TEMFTSGTLR+YR K++RVNI AVK+W RQILRGL YLH  DPPVIHRDLKCDNIFVNG+ G+VKIGDLGLAA+LR SH AH V GTPEFMAPE+YEE YNELVDIY+FGMC+LEM+T EYPYSEC++PAQIYKKV SGK P+A YK++D E ++FV KCL   S RL A ELL DPFL  D                 L    R+P+  L  N +S                    P+++                          GDD  IFL+++I+D++G+  RNIYFPFDI  DTA  VATEMV EL+I+D + ++IA+MI+ EI++L+P  K
Sbjct:   19 YNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTAKRNINFVTEMFTSGTLRQYRLKHRRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGKKPDALYKVKDPEVRQFVEKCLATVSLRLSAKELLNDPFLQIDGCGSDLRPSEPGIEVHGLGPMMRLPYLELHDNTNSYSNGYLNGYGYEAQNEWEYHPVEVEPNGIELFEHHDEHPANVDISIKGKWGDDGGIFLRIRIADKEGR-IRNIYFPFDIETDTASNVATEMVAELDINDQDVTKIADMIDGEIAALVPEWK 432          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRE---LLSTPRIPFQNLMP-------------NDDSAXXXXXXXXXXXXXXXXXXLPLDL------------------------GDD-TIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIP 1116
            + E+LG+GA K VY+AFDE  G+EVAWNQVKL D   SP++L+RLY E+HLLK L H +I+++Y SW+D   R  NF+TEMFTSGTLR+YR K++RVNI AVK+W RQILRGL YLH  DPPVIHRDLKCDNIFVNG+ G+VKIGDLGLAA+LR SH AH V GTPEFMAPE+YEE YNELVDIY+FGMC+LEM+T EYPYSEC++P QIYKKV SGK P+A YK++D E + FV KCL   S RL A ELL DPFL  D  E    L   RI    L P             N  S+                  + ++L                        GDD  IFL+++I+D++G+  RNIYFPFDI NDTA++VATEMV EL+I+D + ++IA+MI+ EI+SL+P
Sbjct:   27 YNEILGRGASKIVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPVQIYKKVISGKKPDALYKVKDPEVRHFVEKCLATVSLRLSARELLNDPFLQIDGCESDLRLLDHRIEVDGLGPLMRPPYLEHHDNNNSYSSGYLNGYDYEAQNEWEYHQVEVELSGIELFEYHDEHPANVDISIKGKRGDDGGIFLRLRIADKEGR-IRNIYFPFDIENDTALSVATEMVAELDITDQDVTKIADMIDGEIASLVP 437          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLS--------------TPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIP 1116
            ++E+LG+GA K VY+AFDE+ G+EVAWNQVK+ D+  +  +L+RL+SEVHLLK L H +II++Y SW+D      NFITE+FTSGTLR+YRQK++ V++ A+K W++QIL GL YLH  DPPVIHRDLKCDNIFVNG+ G+VKIGDLGLAA+L+ +  AHSVIGTPEFMAPELYEEEYNELVDIYAFGMC+LE++T EYPY ECSN AQIYKKVTSG  P +  K++D   + F+ KC+   S RLPA ELL+DPFL SD+  +                + ++       + DSA                         +TIFLK++I+D  G + RNI+FPFD+  DTAIAVA+EMV+EL+++D + S IA MI+ EI S IP
Sbjct:   30 YKEVLGRGAFKKVYRAFDELEGIEVAWNQVKVADLLRNSVDLERLFSEVHLLKTLKHKNIIKFYNSWVDTKNENINFITEIFTSGTLRKYRQKHKHVDLRALKKWSKQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILQQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCLLELVTVEYPYVECSNAAQIYKKVTSGIKPASLAKVKDPAVKAFIEKCIAKVSDRLPAKELLMDPFLRSDEENVSGGCSLRPKAHSSGGISDQLDVNESAKDKDSAAESSRDFSVQGQRKDI---------NTIFLKLRIADSTG-HFRNIHFPFDVKVDTAIAVASEMVEELDVTDQDVSTIAAMIDSEIRSHIP 405          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPL----------DLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPG 1119
            ++E+LG+GA K VY+AFDE  G+EVAWNQVK+ D+  +  +L+RLYSEVHLL  L H +II++Y SWID      NFITE+FTSGTLR+YRQK++ V + A+K W+RQIL GL YLH  DPPVIHRDLKCDNIFVNG+ G+VKIGDLGLAA+L+ +  AHSVIGTPEFMAPELYEEEYNELVDIYAFGMC+LE++T EYPY EC+N AQIYKKVTSG  P +  K++D   + F+ KC    S RLPA ELL+DPFL SD+            +  P   S+                   P+          D+  +TIFLK++I+D  G + RNI+FPFD+  DTAIAVA+EMV+EL+++D + S IA MI+ EI S IPG
Sbjct:   30 YKEVLGRGAFKKVYRAFDEFEGIEVAWNQVKVADLLRNSVDLERLYSEVHLLNTLKHKNIIKFYNSWIDTKNENINFITEIFTSGTLRQYRQKHKHVGLRALKKWSRQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILQQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCLLELVTVEYPYVECTNAAQIYKKVTSGIKPASLAKVKDPAVKAFIEKCTAKVSDRLPAKELLMDPFLQSDEEN-----ESVGHSFRPKAHSSGGSSDQIDVNEIAKDSSAEPIRDFTVQGQRKDI--NTIFLKLRIADSTG-HIRNIHFPFDVEVDTAIAVASEMVEELDLTDQDVSTIAAMIDSEIRSHIPG 404          

Query:    7 EMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPN------------DDSAXXXXXXXXXXXXXXXXXXLPLDL----------------GDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGT 1137
            E LGKGA KTVYKAFDEV G+EVAWNQV ++DV  S  +L+RLYSEVHLLK+L H++II++Y SW+D   +T N ITE+FTSG++R+YR+K++ V++ A+KNWARQILRGL YLH   PP+IHRDLKCDNIFVNG+ G+VKIGDLGLA V++    A SVIGTPEFMAPELYEEEYNELVDIY+FGMC+LEM+T EYPYSEC NPAQIYKKV+SG  P +  K+ D + + F+ KCL  AS RLPA ELL DPFLA+++ + L +  +   NL+              D                       L+L                 D+T+ L ++I+D  G+ ARNI+F F + +DTA+ +A EMV++L++   + + IAE+I+  I+ L+P    W T
Sbjct:   28 EFLGKGAFKTVYKAFDEVDGIEVAWNQVNIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYSSWVDDKNKTINIITELFTSGSMRQYRKKHKTVDMKAIKNWARQILRGLHYLHTHSPPIIHRDLKCDNIFVNGNTGEVKIGDLGLAIVMQ-QPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVSSGIKPASLGKVSDHQVKVFIEKCLVPASTRLPAIELLKDPFLATENSKELVSSSLQLPNLISRQVHLLQSESHLMDIDCKKLSVGSCTKSINESPQFSTLELSRFTENNEFRLRGAKNNDNTVSLTLRIADPCGR-ARNIHFTFYLDSDTAVLIAEEMVEQLDLLTEDVAVIAELIDNLIAKLVP---SWNT 427          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDD-RELLST----PRIPFQNL-MPNDDS------AXXXXXXXXXXXXXXXXXXLPLDL----------------GDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIP 1116
            + E+LGKGA KTVYKAFDEV G+EVAWNQV ++DV  S  +L+RLYSEVHLLK+L H++II++Y SW+D   +T N ITE+ TSG LR+YR+K++ V++ A+KNWARQILRGL YLH   P +IHRDLKCDNI VNG+ G+VKIGDLGLA V++    A SVIGTPEFMAPELYEEEYNELVDIY+FGMC+LEM+T EYPYSEC NPAQIYKKVTSG  P +  K+ DL+ + F+ KCL  AS RL A +LL DPFLA+++ +E++S+    P +  + + +P  +S                         L L+L                 D+T+ L ++I+D  G+ ARNI+F F + +DTA+++A EMV++L++S  + + IAE+I+  I  L+P
Sbjct:   26 YDEILGKGAFKTVYKAFDEVDGIEVAWNQVDIEDVLQSSQQLERLYSEVHLLKSLKHENIIKFYNSWVDDKNKTINMITELLTSGNLRQYRKKHKTVDMKAIKNWARQILRGLQYLHTRSPRIIHRDLKCDNILVNGNNGEVKIGDLGLAIVMQ-QPIARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYSECKNPAQIYKKVTSGIKPASLGKVNDLQVKEFIEKCLVPASVRLSAIDLLKDPFLATENSKEVVSSLSQLPNVICKQVHLPQSESHHMDIDCKMLSLGSCPKSINESPRFLTLELRRFTENNEFRLRAEKNDDNTVSLTLRIADPCGR-ARNIHFTFYLNSDTAVSIAEEMVEQLDLSSEDVAVIAELIDSLIVKLVP 423          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDD 783
            + E+LGKGA KTVYKAFDE  G+EVAWNQVKL D   + ++L+RLY E+HLLK LNH++I+++Y SW+D + R  NF+TEMFTSGTLR+YR K++RVNI AVK+W RQIL GL YLH  DPPVIHRDLKCDNIFVNG+ G++KIGDLGLAA+L+ SH A  V GTPEFMAPE+YEEEYNELVDIY+FGMCVLEM+T EYPYSEC++ AQIYKKVTSGK P+A YK++D E Q+FV KCL   S RL A ELL DPFL  DD
Sbjct:   26 YNEILGKGASKTVYKAFDEYEGIEVAWNQVKLYDSLQTSEDLERLYCEIHLLKTLNHENIMKFYTSWVDTSNRNINFVTEMFTSGTLRQYRLKHRRVNIRAVKHWCRQILEGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEIKIGDLGLAAILKKSHAARCV-GTPEFMAPEVYEEEYNELVDIYSFGMCVLEMVTFEYPYSECNHAAQIYKKVTSGKKPDALYKVKDPELQKFVEKCLATVSTRLSARELLNDPFLQIDD 285          

Query:  919 DDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKK 1128
            DD+IFL+++I+D++G+  RNIYF FDI  DTAI+VATEM+ EL+I++ +  ++A+MI+ EIS+L+P  K+
Sbjct:  374 DDSIFLRLRIADKEGR-IRNIYFSFDIETDTAISVATEMIDELDITEQDVLKVAKMIDDEISTLVPEWKR 442          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXL---------PLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNY--XXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHC--------DLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLISCFGK-SHKS-RFCPSESRAANCYKHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTPGS 1662
            FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKL DVF SPDELQRLYSEVHLLKNLNHDSIIQYY SWID NRRTFNFITEMFTSGTLREYRQKYQ+VNIGAVKNW+RQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRG+ HAHSVIGTPEFMAPELY+EEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFY IEDLEAQRFVGKCLEN SKRLPAHELLLDPFLASDD EL S+PRIPF  L+P++D                               ++L DDTI LKV+ISD DG+N RNIYFPFDI+NDTAI VATEMVKELEI+DWEP EIA MIE EISSLI G KKWG+P+DYH H+HSFNY              PFY           LHA S HC        DLF+NDD                Y+SG EDD  D+   FGK +HKS RFCPS+SR AN YKHCNSQL + RP +LNH   HH+RKLP+IQSLIDV SQLLHRSLVEE+NKR LFKTVG +EN+GFQTPGS
Sbjct:   35 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLNDVFXSPDELQRLYSEVHLLKNLNHDSIIQYYASWIDVNRRTFNFITEMFTSGTLREYRQKYQQVNIGAVKNWSRQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGTQHAHSVIGTPEFMAPELYDEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYNIEDLEAQRFVGKCLENVSKRLPAHELLLDPFLASDDGELASSPRIPFLKLIPDNDPVVEAEDEEDELHFAAEVDLERSTNMIITGKMNLEDDTITLKVRISDLDGKNVRNIYFPFDILNDTAIEVATEMVKELEINDWEPPEIAGMIENEISSLIAGSKKWGSPRDYHPHQHSFNYEEEDDNNNGGITHHPFYAFSSCSSSQNSLHALSFHCKNHDSLQGDLFMNDDVSSQSSFDSCNYSNISYYSGNEDDLLDM--SFGKTTHKSTRFCPSKSRVANTYKHCNSQLDNHRPQKLNH---HHERKLPKIQSLIDVHSQLLHRSLVEEVNKRWLFKTVGTIENVGFQTPGS 604          

Query:   28 MKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXL---------PLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNY--XXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHC--------DLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLISCFGK-SHKS-RFCPSESRAANCYKHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTPGS 1662
            MKTVYKAFDEVLGMEVAWNQVKL DVF SPDELQRLYSEVHLLKNLNHDSIIQYY SWID NRRTFNFITEMFTSGTLREYRQKYQ+VNIGAVKNW+RQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRG+ HAHSVIGTPEFMAPELY+EEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFY IEDLEAQRFVGKCLEN SKRLPAHELLLDPFLASDD EL S+PRIPF  L+P++D                               ++L DDTI LKV+ISD DG+N RNIYFPFDI+NDTAI VATEMVKELEI+DWEP EIA MIE EISSLI G KKWG+P+DYH H+HSFNY              PFY           LHA S HC        DLF+NDD                Y+SG EDD  D+   FGK +HKS RFCPS+SR AN YKHCNSQL + RP +LNH   HH+RKLP+IQSLIDV SQLLHRSLVEE+NKR LFKTVG +EN+GFQTPGS
Sbjct:    1 MKTVYKAFDEVLGMEVAWNQVKLNDVFTSPDELQRLYSEVHLLKNLNHDSIIQYYASWIDVNRRTFNFITEMFTSGTLREYRQKYQQVNIGAVKNWSRQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGTQHAHSVIGTPEFMAPELYDEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYNIEDLEAQRFVGKCLENVSKRLPAHELLLDPFLASDDGELASSPRIPFLKLIPDNDPVVEAEDEEDELHFAAEVDLERSTNMIITGKMNLEDDTITLKVRISDLDGKNVRNIYFPFDILNDTAIEVATEMVKELEINDWEPPEIAGMIENEISSLIAGSKKWGSPRDYHPHQHSFNYEEEDDNNNGGITHHPFYAFSSCSSSQNSLHALSFHCKNHDSLQGDLFMNDDVSSQSSFDSCNYSNISYYSGNEDDLLDM--SFGKTTHKSTRFCPSKSRVANTYKHCNSQLDNHRPQKLNH---HHERKLPKIQSLIDVHSQLLHRSLVEEVNKRWLFKTVGTIENVGFQTPGS 561          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNY-XXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHC--------DLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLISCFGK-SHKS-RFCPSESRAANCYKHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTPGS 1662
            FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKL D F SPDELQRLYSEVHLLKNL HDSIIQYY SWID N RTFNFITEMFTSGTLREYR  YQRVNIGAVKNW+RQILRGLAYLH L PPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRG+ HAHS             +EEYNELVDIYAFGMCV EMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCL N S RLPAH LL DPFLASDD EL S PRI     +P   +                     ++  DDTI L V+ISD DG+NARNIYFPFDI+NDTAI VATEMVKELEISDWEP EIA MIEKEI SLIPG KKWG+P DYH H+HSFNY       X     PFY           LH+F SHC        DLF+NDD                Y+SG EDD HD+   FGK +HKS RFCPSESR AN YK CNSQL +QRPH+LNH   H +RKLP+IQSLIDVRSQLLHRSL EE+NKRRLFKTVG +EN+GFQTPGS
Sbjct:   35 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLNDXFSSPDELQRLYSEVHLLKNLKHDSIIQYYKSWIDVNHRTFNFITEMFTSGTLREYRHXYQRVNIGAVKNWSRQILRGLAYLHXLXPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGTQHAHS-------------DEEYNELVDIYAFGMCVXEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLXNVSXRLPAHXLLXDPFLASDDVELASPPRIS----IPKSTNMIITG---------------KMNPEDDTISLTVRISDLDGKNARNIYFPFDIMNDTAIDVATEMVKELEISDWEPPEIAGMIEKEIFSLIPGXKKWGSPXDYHPHQHSFNYEEEDDDDXGFNHHPFYSFSSCSSSQNSLHSFRSHCKNHNLLHGDLFMNDDVSSQSSFDSCNYSNINYYSGNEDDLHDV--SFGKATHKSTRFCPSESRGANSYKQCNSQLDNQRPHKLNH---HQERKLPKIQSLIDVRSQLLHRSLEEEVNKRRLFKTVGTIENVGFQTPGS 562          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRI----PFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXL------HAFSSHCDLF-----INDDAXXXXXXXXXXXXXXXYFSGTE---------DDHHDLISCFGKSHKS-RFCPSESR------AANCYKHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            F E+LGKGAMKTVYKA DE+LGMEVAWNQVKL  V  SP++LQRLYSEVHLL  LNHDSII++Y SWID   RTFNFITEMFTSGTLREYR+KY +V+I A+KNWARQILRGL YLH  DPPVIHRDLKCDNIF NGHLGQVKIGDLGLAA+LRGS  AHSVIGTPEFMAPELY+E+YNELVD+Y+FGMCVLEMLTSEYPYSEC N AQIYKKVT+GKLP AFY+IEDLEAQRFVGKCL NASKRL A ELLLDPFL     E L   ++    PF N     D                      L+  DDTIFLKVQI+D+DG + RNIYFPFD++NDT   VATEMVKELEI+DWEP EIA MIE EIS+L+P  K    P+ Y    H F Y              +           L      +  ++ CD       + D+                + S  E          D H    C    HKS RFCP E+R      A   ++ C + L      +         RKL R +SL D R QLLHRS+VEE+N+ RLFKTVGAVE IGFQ P
Sbjct:   21 FEEVLGKGAMKTVYKAIDELLGMEVAWNQVKLNQVLRSPEDLQRLYSEVHLLSTLNHDSIIRFYTSWIDIEHRTFNFITEMFTSGTLREYRKKYNQVDIRAIKNWARQILRGLVYLHGHDPPVIHRDLKCDNIFXNGHLGQVKIGDLGLAAILRGSQSAHSVIGTPEFMAPELYDEDYNELVDVYSFGMCVLEMLTSEYPYSECVNAAQIYKKVTAGKLPGAFYRIEDLEAQRFVGKCLVNASKRLSAKELLLDPFLDCGKDESLPLGKLGRPKPFLN-----DKEMEKLQLSDHPTRTDMTITGKLNSEDDTIFLKVQIADKDG-SLRNIYFPFDVLNDTPFDVATEMVKELEITDWEPFEIANMIEGEISALVPDWK----PEAY----HXFKYQDDDKDGPHRPSNSHSYSSSRSSLSGLINSRGINGMTNGCDXLQVADDLLDETSSQSSSHSVTSPNVSFISANEHGTKMFPAGGDKHPXSKC----HKSTRFCPEETRNAGKSIAKKYFERCKAFLASGSKDK----RIMDSRKLMRNRSLGDTRXQLLHRSVVEEVNRXRLFKTVGAVETIGFQAP 581          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKV-------TSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDD--------------RELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLG----------------------------DDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGH-KKWGTPQDYHAHRHSF 1170
            + E+LGKGA KTVY+AFDE  G+EVAWNQVKL D   +P++L+RLY E+HLLK L H++I+++Y SW+D   R  NF+TEMFTSGTLR+YR K++RVNI AVK+W RQIL+GL YLH  DPPVIHRDLKCDNIF+NG+ G+VKIGDLGLAAVLR S HA   +GTPEFMAPE+YEEEYNELVDIY+FGMC+LEM+T EYPYSEC+NPAQIYKKV       + GK P A +K++D E +RFV KCL   S RL A ELL DPFL  DD               E+    R P  +L  ++ S                    P+D G                            DD IFL+++I+D++G+  RNIYFPFD  NDTA++VA EMV EL+I+D + ++IAEMI+ EI++L+P   K  G  +  H +  SF
Sbjct:   26 YNEVLGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLRNPEDLERLYREIHLLKTLKHNNIMKFYTSWVDTTNRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCRQILKGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAVLRKS-HADRCVGTPEFMAPEVYEEEYNELVDIYSFGMCILEMVTFEYPYSECNNPAQIYKKVITVGTLNSQGKKPEALFKVKDPEVRRFVEKCLVTVSXRLSARELLRDPFLQVDDYGYNLRPTEDQRDMYEIGPLLRQPHSSLHQSNSSLSNGHGNYLGYETENDLDYNPIDYGLSEIDLFACQEDEHFGDVDLTIKGRRREDDDIFLRLRIADKEGR-IRNIYFPFDTENDTALSVAREMVSELDITDQDVTKIAEMIDGEITTLVPEWIKGRGIEEIPHCNNASF 463          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDD-RELLSTPRIP--FQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIP 1116
            ++E+LGKGA K VY+AFDE+ G+EVAWNQVK+ D+  + ++L RLYSEVHLLK L H +II++Y SW+DA     N ITE+FTSGTLR+YR+K++ V++ A+K W+RQIL GL YLH  DPPVIHRDLKCDNIFVNG+ G+VKIGDLGLAA+LR +  AHSVIGTPEF APELYEEEYNELVDIYAFGMC+LE++T EYPY ECSN AQI+KKVTSG  P +  K+ D   + F+ KC+   S+RLPA ELL+DPFL SDD RE +S    P  + +   + D                    +     DDTIFLK++I+D  G + RNI+FPFDI  DTAIAVA+EMV+EL+++D + S +AE+I+ EI S IP
Sbjct:   30 YKEVLGKGAFKKVYRAFDELEGLEVAWNQVKVADLLRNSEDLVRLYSEVHLLKTLKHKNIIKFYNSWVDAKHENINIITEIFTSGTLRQYRRKHKHVDLRALKKWSRQILEGLWYLHNHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQARSAHSVIGTPEFXAPELYEEEYNELVDIYAFGMCLLELVTFEYPYVECSNAAQIFKKVTSGVKPASLXKVTDPGVKAFIEKCIVKVSERLPAKELLMDPFLQSDDNRESISRSLRPTHYSDAEGSSDQTDIETKDTDPSHETSRDFSVQGQRKDDTIFLKLRIADSTG-HFRNIHFPFDIGEDTAIAVASEMVQELDLTDQDVSTLAEIIDSEIHSHIP 403          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRE--------------LLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQN-----ARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIP 1116
            + E+LGKGA KTVY+AFDE  GMEVAWNQVKL D   SP++L+RLY E+HLLK L H +I+++Y SW+D   R  NF+TEMFTSGTL++YR K++RVNI AVK+W RQILRGL YLH  DPPVIHRDLKCDNIF+NG+ G+VKIGDLGLAA+LR S  AH V GTPEFMAPE+YEE YNELVDIY+FGMC+LEM+T EYPYSECS+P QIYKKV SGK P+A YK++D E ++FV KCL  AS RL A ELL D FL  D+ E              +    R P   L  ++ S                    P+D+    I L     D   ++      RNIYF FD  NDTA++V+TEMV EL ++D + + IA+MI+  IS L+P
Sbjct:   26 YNEILGKGASKTVYRAFDEYEGMEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHGNIMKFYTSWVDPANRNINFVTEMFTSGTLKQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSQAAHCV-GTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECSHPVQIYKKVVSGKKPDALYKVKDPEVRQFVEKCLATASXRLSARELLNDRFLQXDECEYDLRSLDYSRQLDNMGPFVRQPLLELHXSNSSFSNGYSNGYNFDAPNEWGYQPVDVESTGIELFEHREDDHSEDVGMSRVRNIYFTFDTENDTALSVSTEMVAELVMTDQDVTRIADMIDGVISLLVP 415          

Query:   16 GKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLAS-DDRELLSTPRIP-------------------------FQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIP 1116
            G+   +  Y+AFDE+ G+EVAWNQVK+ D+  + ++L+RLYSEVHLLK L H +II++Y SW+DA     N ITE+FTSGTLR+YR+K++ V++ A+K W+RQIL GL YLH  DPPVIHRDLKCDNIFVNG+ G+VKIGDLGLAA+LR +  AHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLE++T EYPY ECSN AQI+KKVTSG  P +  K+ D   + F+ KC+   S+RLPA ELL+DPFL S DDRE ++    P                           +   + D                    +     DDTIFLK++I+D  G + RNI+FPFDI  DTAIAVA+EMV+EL+++D + S IAE+I+ EI S IP
Sbjct:  408 GRYGRELRYRAFDELEGIEVAWNQVKVADLLRNSEDLERLYSEVHLLKTLKHKNIIKFYNSWVDAKHENINLITEIFTSGTLRQYRRKHKHVDLRALKKWSRQILEGLWYLHNHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQARSAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLELVTFEYPYVECSNAAQIFKKVTSGVKPASLAKVTDPGVKAFIEKCIVKVSERLPAKELLMDPFLQSDDDRESITRSLRPTHYSGKVSFLSSAQRLFVSFSSHCDMLDAEGSSDQIDIETKDMDPSHETNRDFSVQGQRKDDTIFLKLRIADSTG-HFRNIHFPFDIGEDTAIAVASEMVQELDLTDQDVSTIAELIDSEIHSHIP 799          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKV-------TSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTP--------------RIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLD----------------LGD------------DTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIP 1116
            + E+LGKGA KTVY+AFDE  G+EVAWNQVKL D   +P++L+RLY E+HLLK L H +I+++Y SW+D   R  NF+TE+F       YR K++RVNI AVK+W +QIL+GL YLH  DPPVIHRDLKCDNIF+NG+ G+VKIGDLGLAAVLR S HA   +GTPEFMAPE+YEEEYNELVDIY+ GMC+LEM+T EYPYSEC++PAQIYKKV       + GK P A +K++D E  RFV KCL   S+RL A ELL DPFL  D+      P              R P   L  ++ S                    P+D                LGD            D IFL+++I+D +G+  RNIYFPFD  NDTA +VA EMV EL+I+  + ++IAEMI+ EI+SL+P
Sbjct:   26 YNEVLGKGASKTVYRAFDEYEGIEVAWNQVKLYDFQRNPEDLERLYCEIHLLKTLKHSNIMKFYSSWVDTANRNINFVTEIFFW-----YRLKHKRVNIRAVKHWCKQILKGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAVLRKS-HADRCVGTPEFMAPEVYEEEYNELVDIYSLGMCILEMVTFEYPYSECTHPAQIYKKVITVGTQNSQGKKPEALFKVKDPEVXRFVEKCLVTVSRRLSARELLRDPFLQVDEYGYDLRPIEYQGDMYVIGPLLRQPHSALHQSNSSFSNGYGNYLGYETENDLDYNPVDYRLSEIDLLACQEDEHLGDVDLTIKGRRREDDGIFLRLRIADNEGR-IRNIYFPFDTENDTAXSVAREMVSELDITYQDVTKIAEMIDGEIASLVP 439          

Query:   64 GMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTP--------------RIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLD----------------LGD------------DTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIP 1116
            G+EVAWNQVKL D   +P++L+RLY E+HLLK L H +I+++Y SW+D   R  NF+TEMFTSGTLR+YR K++RVNI AVK+W +QIL+GL YLH  DPPVIHRDLKCDNIF+NG+ G+VKIGDLGLAAVLR S HA   +GTPEFMAPE+YEEEYNELVDIY+ GMC+LEM+T EYPYSEC++PAQIYKKV +GK P A +K++D E  RFV KCL   S+RL A ELL DPFL  D+      P              R P   L  ++ S                    P+D                LGD            D IFL+++I+D +G+  RNIYFPFD  NDTA +VA EMV EL+I+  + ++IAEMI+ EI+SL+P
Sbjct:   28 GIEVAWNQVKLYDFQRNPEDLERLYXEIHLLKTLKHSNIMKFYSSWVDTANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCKQILKGLLYLHSHDPPVIHRDLKCDNIFINGNQGEVKIGDLGLAAVLRKS-HADRCVGTPEFMAPEVYEEEYNELVDIYSLGMCILEMVTFEYPYSECTHPAQIYKKVITGKKPEALFKVKDPEVXRFVEKCLVTVSRRLSARELLRDPFLQVDEYGYDLRPIEYQGDMYVIGPLLRQPHSALHQSNSSFSNGYGNYLGYETENDLDYNPVDYRLSEIDLLACQEDEHLGDVDLTIKGRRREDDGIFLRLRIADNEGR-IRNIYFPFDTENDTAXSVAREMVSELDITYQDVTKIAEMIDGEIASLVP 418          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPN-DDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNY--XXXXXXXXXXXXPFYXXXXXXXXXXXLHAF-----SSHCDLFINDDAXXXXXXXXXXXXXXXYFSGTEDDH----HDLISCFGKSHKS-RFCPSESRAANCYKHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTPG 1659
            FRE+LGKGAMKTVYKAFDEVLGMEVAWNQVKL DVF SP+ELQRLYSEVHLLKNLNHDSII++Y SWID +RR FNFITEMFTSGTLR YR+KYQRV+I A+KNW+RQILRGLA+LH  DPPVIHRDLKCDNIF+NGHLG VKIGDLGLAAVL+GS HAHSVIGTPEFMAPELYEE+Y+ELVDIY+FGMCVLEMLT EYPYSECSNPAQIYKKVTSGKLP AFY+IED+EAQ F+GKCL  ASKRLPA ELLLDPFLASD+ EL + P++P     P   +                      ++  DDTIFLKV+IS++DGQ  RNIYFPFDI+NDTAI VA EMVKELEI+DWEP EIA+MIE++ISSLIPG K+  + Q +H  +H F+Y              PF+           L AF     +  C+LFI+DDA               Y SG EDD+     ++   FGK HKS RFCP++S +A  YKH N++L        N      QRKL RI+S +DVR+QLLHRSL+EEINKRRLFKTVGAVENIG+  PG
Sbjct:   31 FREVLGKGAMKTVYKAFDEVLGMEVAWNQVKLHDVFRSPEELQRLYSEVHLLKNLNHDSIIKFYTSWIDIDRRAFNFITEMFTSGTLRAYRKKYQRVDIRAIKNWSRQILRGLAFLHGHDPPVIHRDLKCDNIFINGHLGHVKIGDLGLAAVLQGSQHAHSVIGTPEFMAPELYEEDYDELVDIYSFGMCVLEMLTFEYPYSECSNPAQIYKKVTSGKLPEAFYRIEDVEAQEFIGKCLATASKRLPARELLLDPFLASDEAELGTIPKVPSPWSSPKVTEEKIMPSLLADPTKATEMTVTGTMNPQDDTIFLKVKISEKDGQ-TRNIYFPFDIMNDTAIDVAMEMVKELEITDWEPFEIADMIEEQISSLIPGWKQCSSSQIHHP-QHCFSYEDDDDDDHNDGPRHPFFASSSHSSSQASLLAFNCSFQTKPCELFIDDDASSQSSLNSFKYSTLNYSSGNEDDYDASLREVPLGFGKIHKSTRFCPADSLSAKQYKHRNARLDSGGCCSSN-----PQRKLSRIRSQVDVRNQLLHRSLLEEINKRRLFKTVGAVENIGYHEPG 589          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNY-XXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSS----------------------HCDLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLIS-----CFGKSHKS-RFCPSESRAANCYKHCNSQLHHQRPHELNHPLC---HHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTPG 1659
            FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKL DV  S DEL RLYSEVHLLKNL H+SII++Y SWID +RRTFNFITEMFTSGTLREYR+KYQ V+I AVKNWARQIL+GLAYLH  DPPVIHRDLKCDNIF+NGHLGQVKIGDLGLAA+LRGS HA SVIGTPEFMAPELYEEEYNELVDIY+FGMCVLEM TSEYPYSECSNPAQIYKKVTSGKLP AFYKI+D EAQ+FVGKCLE+ASKRLPA ELLLDPFL+SD+ +LL   +IP Q    N                        ++  DDT+FLKVQISD+DG + RNIYFP+D +NDTAI VA EMVKELEI+DWE  +IAEMIE++I+SLIP  K+WG  Q     +HSFNY             PF+           L A SS                        +LF NDD                Y SG ED             F K+HKS RFCP++S        C+ Q H QR  +L    C     Q KL R +SL+DVRSQLLH+SL+E+I+KRRLFKTVGAVENIGF  PG
Sbjct:   33 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLNDVLSSADELHRLYSEVHLLKNLKHESIIKFYSSWIDIDRRTFNFITEMFTSGTLREYRKKYQHVDIRAVKNWARQILQGLAYLHGHDPPVIHRDLKCDNIFINGHLGQVKIGDLGLAAILRGSQHARSVIGTPEFMAPELYEEEYNELVDIYSFGMCVLEMFTSEYPYSECSNPAQIYKKVTSGKLPEAFYKIKDTEAQKFVGKCLESASKRLPARELLLDPFLSSDEGKLLPVTKIPIQRSSSNASEEIIPSLLADPTKDTEMTITGTMNPDDDTVFLKVQISDKDG-HTRNIYFPYDTMNDTAIDVAVEMVKELEITDWESLDIAEMIEEQIASLIPSSKEWGLFQ----QQHSFNYDDDDEYDNDGNHHPFHSFSSRSSSQASLLALSSPYENPHLHGGSNTNVTCSLDWLQGELFTNDDTSSQSSFNSIKYSNLNYCSGNEDSCETSTRGGEHLSFAKAHKSTRFCPADSNL------CSKQ-HKQRNAQLGSWECSSSSSQPKLSRHRSLVDVRSQLLHKSLLEQIHKRRLFKTVGAVENIGFHEPG 605          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRE-LLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXL-PLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNY---XXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHCD-------------------LFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLIS------CFGKSHKS-RFCPSESRAANCYKHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTPG 1659
            FRE+LGKGAMKTVYKAFDE LGMEVAWNQVKL DVF SPD+LQRLYSEVHLLKNL+HDSI++++ SWID +  TFNFI+EMFTSGTLREYRQKY+RV+IGAVKNWARQIL GLAYLH  DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRGS HAHSVIGTPEFMAPELYEEEY+ELVD+Y+FGMCVLEMLTSEYPY ECSNPAQIYKKVTSGKLP AFY+IED+EA+ FVG+CLE+ +KRLPA ELL+DPFLA D  E +L   +I  Q   PN                         ++  D TIFLKV ISD+DG  +RNIYFPFDI +DT I VA EMV+ELEI+DWEP EIA+MIE+EI +L+P  K+  +P++   H+HSF Y               PFY           L   S  C+                   L INDDA               Y S TE+D   L            +HKS RFCP E  ++  +  CN     +RP++ N   CH  RKL RI+S +DVRSQLL RSL+E INKRRLFKT+GAVENIG+Q PG
Sbjct:   31 FREILGKGAMKTVYKAFDEFLGMEVAWNQVKLNDVFNSPDDLQRLYSEVHLLKNLDHDSIMRFHTSWIDLDGGTFNFISEMFTSGTLREYRQKYKRVDIGAVKNWARQILHGLAYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQHAHSVIGTPEFMAPELYEEEYDELVDVYSFGMCVLEMLTSEYPYCECSNPAQIYKKVTSGKLPEAFYRIEDVEAREFVGRCLEHVAKRLPAKELLMDPFLAVDHGEQMLPMLKISSQKPSPNGTVEKIPSFQTNPRKRSTDMTITGTINPDDYTIFLKVAISDKDGL-SRNIYFPFDIGSDTPIDVAAEMVRELEITDWEPFEIAKMIEEEIFALVPSWKQCTSPEN---HQHSFEYEEEEEEEDDDDETYHPFY-CYASESSRVALQDLSISCEIQSQHRNHMISGEDWFQEGLLINDDASSQSSLNSDKYSTLVYCSVTENDIDHLAPKRVEPIFTASTHKSTRFCPEEGTSS--WNQCNGS---RRPYDSN---CH--RKLSRIKSFVDVRSQLLRRSLMEMINKRRLFKTIGAVENIGYQEPG 599          

Query:    7 EMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXL---HAFSSHC--------DLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLISCF-------GKSHKS-RFCPSESRA------ANCYKHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            E+LGKGAMKTVYKA DEVLGMEVAWNQVKL +V  SPDELQRLYSEVHLL  LNHDSIIQ+Y SWID  R+TFNFITE FTSGTLREYR+KY+RV+I A+K WARQILRGL YLH  DPPVIHRDLKCDNIFVNGHLG+VKIGDLGLAA+LRGS  AHSVIGTPEFMAPELYEE YNELVD+Y+FGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLP AFY+I+DLEAQRF+GKCL  ASKRLPA ELLLDPFLASD+ + L  P++  Q    ND                       L+  DDTIFLKVQ +D+DG +ARNIYFPFDIV DT I VA EMVKELEI+DWEP EIA+MI+ EIS+L+P  KKW  PQ +H   ++F+Y             F            L   H   +          DLF  DD                YFSG E  H    S          K+ KS RFCP E+ +         YK        QR             +L R +SL+DVRSQLLHR+LVEE++KRRL KTVGAVENIGFQ P
Sbjct:   33 EVLGKGAMKTVYKAIDEVLGMEVAWNQVKLNEVLRSPDELQRLYSEVHLLSALNHDSIIQFYTSWIDVERKTFNFITEFFTSGTLREYRKKYKRVDIRAIKCWARQILRGLVYLHGHDPPVIHRDLKCDNIFVNGHLGEVKIGDLGLAAILRGSQSAHSVIGTPEFMAPELYEENYNELVDVYSFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPGAFYRIQDLEAQRFIGKCLVTASKRLPAKELLLDPFLASDEAKRLPKPKLGSQKPFLNDIRIEKLRLSDDRVRTNMTITG-TLNPDDDTIFLKVQTADKDG-SARNIYFPFDIVTDTPIDVAMEMVKELEITDWEPFEIADMIDGEISALVPQWKKWDMPQQHH---YAFDYQEEDEGHNHPFRSFSSCSSSQASFPCLSTSHRLDTMAQGGDWLKDDLF--DDTSSESSAHSGKYSNLNYFSGNE--HCSETSTLRREQHPGAKTQKSTRFCPEENSSTRKALPGKSYKQGKVLQESQRAPGSKDKFAMETIRLTRNRSLVDVRSQLLHRTLVEEVHKRRLSKTVGAVENIGFQAP 598          

Query:    7 EMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHC---DLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLISCFGKSHK---------SRFCPSESR--------AANCYKHCNSQLHHQR-PHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            E+LGKGAMKTVYKA DEVLGMEVAWNQVKL +V  SP++LQRLYSEVHLL  LNHDSIIQ+Y SWID +R+TFNFITEMFTSGTLREYR+KY+RVNI A+KNWARQIL+GL YLH  DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRGS  AHSVIGTPEFMAPELYEEEYNELVD+Y+FGMCVLEMLTSEYPYSEC NPAQIYKKVTSGKLP AFY+++DLEAQ+F+GKCL  ASKRL A ELLLDPFLASD+ E     R   Q    ND                     L  +  DDTIFLKVQI+++DG + RNIYFPFDI+NDT++ VA EMVK+L+I DWEP EIAEMI+ EI SL+P  KKW  PQ   A+ H+FNY            PF+           L    +     DL   DD                Y S   DDH    S   +  K         +RFCP ++         A + YK+C   L  Q              R+L R +SL+D+RSQLLHRSLVEE+NKRRLFKTVG VEN+GFQ P
Sbjct:   33 EVLGKGAMKTVYKAIDEVLGMEVAWNQVKLNEVLRSPEDLQRLYSEVHLLSTLNHDSIIQFYTSWIDVHRKTFNFITEMFTSGTLREYRRKYKRVNIQAIKNWARQILQGLVYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQLAHSVIGTPEFMAPELYEEEYNELVDVYSFGMCVLEMLTSEYPYSECVNPAQIYKKVTSGKLPAAFYRVQDLEAQKFIGKCLVAASKRLSAKELLLDPFLASDEAESPPLSRSENQKPFLNDSEMKKLHLNDPPRTDMTITGKLKSE--DDTIFLKVQIANKDG-SLRNIYFPFDILNDTSMDVAMEMVKDLDIDDWEPFEIAEMIDGEICSLVPNWKKWDLPQ-IEAY-HTFNY----QEDDGLDHPFHSSSSCSSSQASLSGLMAQWVPDDLI--DDTSSESSSHSGSYSNLNYVS--SDDHKFNTSTTRRPDKHPMTRNQNSTRFCPRDNSSSYIGQAIARDAYKYCKVLLESQSGASSSKQKRVMDGRRLTRNRSLVDIRSQLLHRSLVEEVNKRRLFKTVGDVENVGFQAP 590          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHC---DLFINDDAXXXXXXXXXXXXXXXYFSGTEDDH-HDLISCFGKSH-------KSRFCPSESR--------AANCYKHCNSQLHHQ-RPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            F E+LGKGAMKTVYKA DE LG+EVAWN+VKL  V  SPD+LQRLYSEVHLL  LNHDSII++Y SWID  R+TFNFITEMFTSGTLREYR+KY RVNI A+K WARQIL G+ YLH  DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRGS  AHSVIGTPEFMAPELYEE YNELVD+Y+FGMCVLEMLTSEYPYSEC+NPAQIYKKVTSGKLP  F++I+DLEAQRF+GKCL  A+KRL A ELLLDPFLASD+ EL   PR   Q    ND                       L+  DDTIFLKVQI++ DG   RNI+FPFDI++DT I VA EMVKELEI DWEP EIA+MI+  IS+L+P  KKW  P  +    H+F+Y            PF+           L     H    DLF  DD                Y SG  D+H  DL S     H        +RFCP E+         A N Y HC   L  Q R            R+L R +SL+D+RSQLLHRSLVEE++KRRL KTVG VE++GFQ P
Sbjct:   33 FEEVLGKGAMKTVYKAIDEFLGIEVAWNRVKLNQVLCSPDDLQRLYSEVHLLSTLNHDSIIKFYTSWIDVRRKTFNFITEMFTSGTLREYRKKYTRVNIRAIKKWARQILEGIVYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQSAHSVIGTPEFMAPELYEENYNELVDVYSFGMCVLEMLTSEYPYSECTNPAQIYKKVTSGKLPAVFHRIQDLEAQRFIGKCLVTAAKRLSAKELLLDPFLASDEAELPHVPRFRKQKPFLNDREMEKLQLNDHPPRTDMTITG-KLNPEDDTIFLKVQIANEDG-TLRNIFFPFDILHDTPIDVAMEMVKELEIDDWEPFEIADMIDGAISALVPNWKKWDLP--HIESHHTFDY----QEDDGHDHPFHSSSSCSSSPASLSGLMPHLLQDDLF--DDTSSQSSSHSGSYSCLNYISG--DEHKFDLSSTRRDKHLITRTQNSTRFCPQENSNSNIGQALATNAYNHCKVLLESQTRASSSKSKRMMDSRRLTRNRSLVDIRSQLLHRSLVEEVHKRRLSKTVGDVEDVGFQKP 592          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDREL-LSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXL----PLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSS--------------------HCDLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLISCFGKSHK----------SRFCPSES--RAANCYKHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            FR++LGKGA+K VY+AFDEVLG+EVAWNQVKL DVF SPD L RLYSEVHLLKNL HDSI+ ++ SWID N RTFNFITE+FTSGTLREYR+KYQRV+I AVKNWARQIL GL YLH  DPPVIHRDLKCDNIF+NGHLGQVKIGDLGLAA+LRGS HAHSVIGTPEFMAPELYEEEYNELVDIY+FGMC++E+ TSE+PYSECSNPAQIYKKVTSGKLP A+Y+I DLEAQRFVGKCL N S+RL A ELLLDPFLA +  +  L +P +P +     + +A                  +     ++  DDT+FLKVQIS++DGQ  RNI+FPFD + DTAI VA EMVKELEISD EP EIA+MIE+EIS+L+P  + WG+ +  +  +HSF+Y            PF+           L  F S                      +LF+NDDA                     +D HD     G  H            RFCP E    A    + CN ++   R        CH   +L RI+S +D+R Q L RSL+EEI+KRR+FKTVGAVENIGFQ P
Sbjct:   26 FRDILGKGAVKVVYRAFDEVLGIEVAWNQVKLGDVFHSPDLLPRLYSEVHLLKNLEHDSIMTFHDSWIDVNCRTFNFITELFTSGTLREYRKKYQRVDIRAVKNWARQILSGLEYLHSHDPPVIHRDLKCDNIFINGHLGQVKIGDLGLAAILRGSQHAHSVIGTPEFMAPELYEEEYNELVDIYSFGMCMIEIFTSEFPYSECSNPAQIYKKVTSGKLPEAYYRIHDLEAQRFVGKCLANVSERLSAKELLLDPFLAKEQLDSPLPSPTLPKKQAPTLNFTASLAKELSQPKSNQTKDSHMTITGSINEEDDTVFLKVQISNKDGQK-RNIFFPFDTIYDTAIDVAMEMVKELEISDLEPLEIAKMIEEEISALVPKWRDWGSAE--YQKQHSFSY--EEEYDMSNHHPFFSTSSRSSSHASLPVFGSSYKNNSHYRGNHYPFAQDWPQDELFMNDDASSQSSMNSFKCFNFNCCDPGNEDEHDPTLVLGAEHLYYTPKGNEKCIRFCPREEVMDADFTKQLCNMRMDSHR--------CHGMHRLTRIRSFVDLRRQQLQRSLMEEIHKRRMFKTVGAVENIGFQNP 601          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDREL-LSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPL----DLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXLHAF-------SSH--------------CDLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLISCFGKSH----------KSRFCPSESRAANCY--KHCNSQLHHQRPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            FR++LGKGA+K VY+AFDEVLG EVAWNQVKL DVF SPD L RLYSEVHLLKNL HDSI+ ++ SWID + RTFNFITE+FTSGTLREYR+KYQRV+I AVKNWARQIL GL YLH  DPPVIHRDLKCDNIF+NGHLGQVKIGDLGLAA+LRGS HAHSVIGTPEFMAPELYEEEYNELVDIY+FGMC++E+ TSE+PYSECSNPAQIYKKVTSGKLP A+Y+I DLEAQ+FVGKC  N S+RL A ELLLDPFLA++  +  L +P +P +     + +A                  + +    +  +DT+FLKVQIS+++GQ  RNI+FPFD +NDTAI VA EMVKELEISD EP EIAEMIE+EIS+L+P  + WG+ +  +  +HSF+Y            PF+           L  F       SSH               +LF+NDDA                     +D HD     G  H           +RFCP E    + +  + CN ++   R        CH   +L RI+S +D+R Q   RSLVEEI+KRR+FKTVGA+ENIGFQ P
Sbjct:   26 FRDILGKGAVKVVYRAFDEVLGREVAWNQVKLGDVFHSPDLLPRLYSEVHLLKNLEHDSIMTFHDSWIDVHCRTFNFITELFTSGTLREYRKKYQRVDIRAVKNWARQILSGLEYLHSHDPPVIHRDLKCDNIFINGHLGQVKIGDLGLAAILRGSQHAHSVIGTPEFMAPELYEEEYNELVDIYSFGMCMIEIFTSEFPYSECSNPAQIYKKVTSGKLPEAYYRIHDLEAQKFVGKCSANVSERLSAKELLLDPFLATEQLDSPLPSPTLPKKQTPTLNFTALLAKELPPPKSNQTKDTHMTITGSTNEENDTVFLKVQISNKNGQK-RNIFFPFDTINDTAIDVAMEMVKELEISDLEPLEIAEMIEEEISALVPTWRDWGSAK--YQKQHSFSY--EEAYDMSNHHPFFSPTSRSSSHASLPVFGSSSYKNSSHHRENHYPFAQDWPQDELFMNDDASSQSSMNSFKCFNLNCCDPGNEDEHDPTLALGAEHLFYTPKGNEKYTRFCPREEVMESDFTKQFCNMRMDSHR--------CHGMHRLTRIRSFVDLRRQQQQRSLVEEIHKRRMFKTVGAIENIGFQDP 602          

Query:    7 EMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIG-TPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHCDLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLISCFGKSH-------KSRFCPSESR--------AANCYKHCNSQLHHQ-RPHELNHPLCHHQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            E+LG+GAMKTVYKA DE LG+EVAWNQ KL  V  SP++LQRLYSEVHLL+ LNHDSII++Y SWID   +TFNFITEMFTSGTLR+YRQKY RVNI A+K WARQIL G+ YLH  DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRGS  AHSVIG TPEFMAPELYEE YNELVD+Y+FGMCVLEMLT+EYPYSEC+NPAQIYKKVTSGKLP  FY+I+DLEAQRF+GKCLE ASKRLPA ELLLDPFLASD+ EL   PRI  Q    ND                       L+  DDTIFLKVQI++ DG   RNI+FPFDI++DT I VA EMVKELEI DWEP EIA+MI+  IS L+P  KKW  P  +   RH F+Y              Y            H      DLF  DD                Y SG E    DL +   + H        +RFCP E+         A N Y +C   L  + R            R+L R +SL+D+RSQLLHRSLVEE++KRRL KTVG VE++GFQ P
Sbjct:   34 EVLGRGAMKTVYKAIDEFLGIEVAWNQAKLSRVLCSPEDLQRLYSEVHLLRILNHDSIIKFYASWIDVRGKTFNFITEMFTSGTLRQYRQKYTRVNIRAIKKWARQILEGIEYLHGHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQSAHSVIGSTPEFMAPELYEENYNELVDVYSFGMCVLEMLTAEYPYSECTNPAQIYKKVTSGKLPAVFYRIQDLEAQRFIGKCLETASKRLPAKELLLDPFLASDEAELSRVPRIRNQKSFLNDREMEKLQLNDHPPRTDMIITG-KLN-RDDTIFLKVQIANEDG-TPRNIFFPFDILHDTPIDVAMEMVKELEIGDWEPFEIADMIDGAISDLVPNWKKWDLP--HTEPRHIFDYQEDDGHNHPFHSSSYSSSHSSLSGSTPHLLQD--DLF--DDTSSQSSSHSGSYSCLNYISGYE-HKLDLSTTRREKHLDTRTQNSTRFCPRENSNSNIGQVLATNAYNNCKVLLESKSRVSSSKSKRMMDSRRLTRNRSLVDIRSQLLHRSLVEEVHKRRLSKTVGDVEDVGFQAP 590          

Query:    1 FREMLGKGAMKTVYKAFDEVLGMEVAWNQVKLKDVFGSPDELQRLYSEVHLLKNLNHDSIIQYYMSWIDANRRTFNFITEMFTSGTLREYRQKYQRVNIGAVKNWARQILRGLAYLHKLDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAVLRGSHHAHSVIGTPEFMAPELYEEEYNELVDIYAFGMCVLEMLTSEYPYSECSNPAQIYKKVTSGKLPNAFYKIEDLEAQRFVGKCLENASKRLPAHELLLDPFLASDDRELLSTPRIPFQNLMPNDDSAXXXXXXXXXXXXXXXXXXLPLDLGDDTIFLKVQISDRDGQNARNIYFPFDIVNDTAIAVATEMVKELEISDWEPSEIAEMIEKEISSLIPGHKKWGTPQDYHAHRHSFNYXXXXXXXXXXXXPFYXXXXXXXXXXXLHAFSSHCDLFINDDAXXXXXXXXXXXXXXXYFSGTEDDHHDLISCFGKS---------HKSRFCPSE------SRAANCYKHCNSQLHHQRPHELNHPLCH-HQRKLPRIQSLIDVRSQLLHRSLVEEINKRRLFKTVGAVENIGFQTP 1656
            F E+LGKGAMKTVY+A DE+LGMEVAWNQ+KL D+  SP++++RLYSEVHLL  LNH SI+++Y SWID   RTFNFITEMFTSGTLR YR+KYQRV+I A+KNWARQIL GL YLH+ DPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAA+LRGS  AHSVIGTPEFMAPELYEE YNELVD+Y+FGMC+LEMLT EYPYSEC NPAQIYKKVTSGK P AFYK++DL+AQRF+ KCLE ASKRL A EL++DPFL  ++ +  S   +  Q    ND  A                    L+  DDTI +KVQI+D+ G + RN+YFPFDIV DT   VA EMVKELEI+DW+P EIA MI+ EIS L+P  KKW   Q   A  H  +Y            PF            L       D+F  DD                YFS   DD +D ++   K          H SRFCP E      S A  CYK C   L  +R    +        R+L R +SL+D+RSQLLH++LVEE++KRRLFKTVGAVENIGFQ P
Sbjct:   31 FEEVLGKGAMKTVYRAIDELLGMEVAWNQIKLNDLLHSPEDMERLYSEVHLLSTLNHHSIMRFYTSWIDVEHRTFNFITEMFTSGTLRGYRKKYQRVDIRAIKNWARQILEGLVYLHEHDPPVIHRDLKCDNIFVNGHLGQVKIGDLGLAAILRGSQRAHSVIGTPEFMAPELYEENYNELVDVYSFGMCMLEMLTGEYPYSECVNPAQIYKKVTSGKRPRAFYKVQDLDAQRFIRKCLEPASKRLSAKELMVDPFLVFNNVDGKSVTMMQLQKPFLNDKIAIEDLHLNEDAPRTNMTITGKLNPEDDTILIKVQIADKKG-DVRNVYFPFDIVTDTPTEVANEMVKELEITDWKPYEIANMIDGEISGLVPQWKKWN--QFESADYHVLSYKDDDNDHHN---PFRGFSSCSSSQVSLSG-----DMF--DDTSSQSSSHSANYSNFNYFS---DDENDPVTTSTKQSQPATAINHHTSRFCPGENSSTGQSLARMCYKQCKDMLELKRTSSTSKEKGKVDTRRLTRNKSLVDMRSQLLHKTLVEEVHKRRLFKTVGAVENIGFQQP 582