MDP0000250455, MDP0000250455 (mRNA) Malus spp. (apple)

Query:   28 DLWKSKALSVQLRLRQRFRVEVDRRLRHHPIFSNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLA--XVTQPQNLPXXDTDRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAA-PPYTEEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEAN 1428
            DLWKS+A S+QLRLR RFR+ VDR  R  P+FS DGYFSST QRWL+R RDFRRDSLPSS+ FY KRVGK+  AEE+S+ +RMLQA+AVPVIGNVC+VFM+GLN+VQVYG EKLH+ +L RP+ KPLITVSNHVAS+DDPLV+++LLP  VLLD ++LRWT+CA+DRCF NPVTSAFF+ VKVLPVSRG+GIYQK                    GMD+A+SKLN GGWVHIFPEG RSRDGGKT+GS KRGVGRLVLDADN P+VVPFVH+GMQ++MPIGA+ PRIG  VTV+IGDPI+FDDLLN +  +H+SRGKLYDAVSSR+ HRL+ELKVQVDKLA     Q QN     T+RA  IL QVDWESFGMG+   SE+D S+  E +  +      T+E   ++  + +GFS EGGI S +R +MD +E MGFAARG+F+NRRAEE   S + + PLKAW+++LEAN
Sbjct:    3 DLWKSRARSLQLRLRDRFRIAVDRH-RRLPMFSTDGYFSSTLQRWLRRVRDFRRDSLPSSSAFYRKRVGKDIGAEEDSVFVRMLQALAVPVIGNVCYVFMHGLNRVQVYGAEKLHEVLLHRPENKPLITVSNHVASVDDPLVIASLLPPSVLLDARSLRWTMCATDRCFKNPVTSAFFQCVKVLPVSRGEGIYQK--------------------GMDMAVSKLNSGGWVHIFPEGSRSRDGGKTMGSAKRGVGRLVLDADNTPIVVPFVHTGMQEVMPIGANFPRIGQAVTVLIGDPIHFDDLLNEQQTQHMSRGKLYDAVSSRVSHRLQELKVQVDKLALEHSIQLQNHDMQTTERAAGILHQVDWESFGMGSYITSENDSSSRLEIQSPMKLNVTNTQEHAPSERYFGMGFSYEGGIVSRIRGYMDPTELMGFAARGLFLNRRAEEKLASIQEIRPLKAWKQFLEAN 451          

Query:   28 DLWKSKALSVQLRLRQRFRVEVDRRLRHHPIFSNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLA--XVTQPQNLPXXDTDRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAA-PPYTEEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEAN 1428
            DLWKS+A S+QLRLR RFR+ VDR  R  P+FS DGYFSST QRWL+R RDFRRDSLPSS+ FY KRVGK+  AEE+S+ +RMLQA+AVPVIGNVC+VFM+GLN+VQVYG EKLH+ +L RP+ KPLITVSNHVASMDDPLV+++LLP  VLLD ++LRWT+CA+DRCF NPVTSAFF+ VKVLPVSRG+GIYQK                    GMD+A+SKLN GGWVHIFPEG RSRDGGKT+GS KRGVGRLVLDADN P+VVPFVH+GMQ++MPIGA+ PRIG  VTV+IGDPI+FDDLLN E  +H+SRGKLYDAVSSR+  RL+ELKVQVDKLA     Q QN     T+ A  IL QVDWESFGMG+   SEDD S+  E +  +      T+E   ++  + +GFS EGGI S +R +MD +E MGFAARG+F+NRRAEE   S + + PLKAW+++LEAN
Sbjct:    3 DLWKSRARSLQLRLRDRFRIAVDRH-RRLPMFSTDGYFSSTLQRWLRRVRDFRRDSLPSSSAFYRKRVGKDIGAEEDSVFVRMLQALAVPVIGNVCYVFMHGLNRVQVYGAEKLHEVLLHRPENKPLITVSNHVASMDDPLVIASLLPPSVLLDARSLRWTMCATDRCFKNPVTSAFFQCVKVLPVSRGEGIYQK--------------------GMDMAVSKLNSGGWVHIFPEGSRSRDGGKTMGSAKRGVGRLVLDADNTPIVVPFVHTGMQEVMPIGANFPRIGQAVTVLIGDPIHFDDLLNEEQTQHMSRGKLYDAVSSRVSRRLQELKVQVDKLALEHSIQLQNHDMQTTEWAAGILHQVDWESFGMGSYITSEDDSSSRLEIQSPMKLNVTNTQEHAPSERYFGMGFSYEGGIVSRIRGYMDPTELMGFAARGLFLNRRAEEKLASIQEIRPLKAWKQFLEAN 451          

Query:    1 MAAARVERGDLWKSKALSVQLRLRQRFRVEVDRRLRHHPIFSNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAXVTQPQNLPXXDTDRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAAPPYT--EEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEAN 1428
            MA  R+ER DLWKSKA  +QLRLR RFRV VDR  R  PI+ +D YF S  QRW+ RFRDFR  SL S + FY KRV +EFNAEEES+I+RMLQ+VAVP+IGN+C+VFMNGLN+VQVYG+EKLHDA+L RP+ KPL+TVSNHVAS+DDP V+++LLP  VL+D QNLRWTLCA+DRCF NPVTSAFFRSVKVLPVSRGDGIYQK                    GMD+AI+KLN GGWVHIFPEG RSRDGGKT+GS KRGVGRL+LDAD +PMV+PFVH+GMQ+IMPIGA  PRIG TVTV++GDPI FDDL N+E  + VSRGKLYDAV+SRIG +L ELKVQV+ LA     ++     T+RA  IL QVDW+SFGMG+    +DD S   ++EI L  P +T  +EP S+D  +R   S E GI S M  FMD +E + FAA+G+FMN R +E   S   V+P++AWR YL AN
Sbjct:    1 MAVHRIERADLWKSKARILQLRLRDRFRVAVDRHRRRPPIYLDDDYFLSKVQRWITRFRDFREGSLHSRSAFYRKRVSREFNAEEESVIIRMLQSVAVPLIGNMCYVFMNGLNRVQVYGLEKLHDALLHRPRNKPLLTVSNHVASVDDPFVIASLLPPGVLMDAQNLRWTLCATDRCFRNPVTSAFFRSVKVLPVSRGDGIYQK--------------------GMDMAIAKLNSGGWVHIFPEGSRSRDGGKTMGSSKRGVGRLILDADTVPMVIPFVHTGMQEIMPIGAKFPRIGKTVTVLVGDPIIFDDLFNAEEREQVSRGKLYDAVASRIGSQLLELKVQVENLAFQQSIKHQHPSATERAADILHQVDWDSFGMGSHVIRKDDTS---DSEI-LPKPNFTSHQEPISSDGYFRTRSSPEVGIISRMHSFMDSTELLSFAAKGLFMNLRRKENRSSFGDVSPVRAWRHYLLAN 454          

Query:    1 MAAARVE--RGDLWKSKALSVQLRLRQRFRVEVDRRLRHHPIFS--NDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLA--XVTQPQNLPXXDTDRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAAPPYTEEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEAN 1428
            MA  R+E  RGDLWKSKA ++QLRLR RFRV VDR  R   IFS  +DGYFSST QRWL  FRDFRRDSL S + FY KRV K+FNA+EES+I+RM+Q+VAVP++GN+CHVFM+GLN+VQVYGVEKLHDA+L RPK KPL+TVSNHVAS+DDP ++++LLP  VL+D QNLRWTLCASDRCF NPV+SAFF+SVKVLPV+RG+GIYQK                    GMD+AI+KLN G WVHIFPEG RSRDGGKT+GS KRGVGRL+LDAD +P+V+PFVH+GMQ+IMPIGA++PRIG  VTV++GDPI+FDD+L++EG +++SRGK+YDAVSSRIG RL++LKVQV+KLA     + Q      T+RA  +LQQVDW SFG G+   +E+     +        P  ++E  S+   +R+GFS +  I S MR +MD +E +GFAARG+FMN RA E + S R V P++AW+++LEAN
Sbjct:    1 MAVQRIELGRGDLWKSKAKALQLRLRDRFRVVVDRHRRRPHIFSAASDGYFSSTVQRWLNHFRDFRRDSLHSHSAFYRKRVSKDFNADEESVIIRMVQSVAVPLLGNMCHVFMHGLNRVQVYGVEKLHDALLHRPKNKPLLTVSNHVASVDDPFIIASLLPPSVLMDAQNLRWTLCASDRCFKNPVSSAFFQSVKVLPVARGEGIYQK--------------------GMDMAIAKLNSGSWVHIFPEGSRSRDGGKTMGSSKRGVGRLILDADTVPLVIPFVHTGMQEIMPIGATLPRIGKRVTVLLGDPIHFDDILDAEGVENISRGKMYDAVSSRIGQRLQQLKVQVEKLALEQSVEFQQAAAGITERAADMLQQVDWGSFGAGSHVSTEERDLPCE--------PRPSQELLSSGRYFRIGFSYDSIIISRMRGYMDSTELLGFAARGLFMNFRAREHTASIRDVGPVRAWKQFLEAN 454          

Query:   16 VERGDLWKSKALSVQLRLRQRFRVEVDRRLR----HHPIF-SNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLL--NSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLA--XVTQPQNLPXXDTDRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAAPPYTEEPQS--ADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEAN 1428
            ++RGD+WKSKA S+QL+LR RFRV VDR  R    HH    S DGYFSST QRWL RFRDFRRDSLPSST+FY KRV K+F++EE+S ++RM+QAVAVPV+GNVCHVFMNGLN VQVYG+EKLH A+L+RPKGKPL+TVSNHVASMDDPLV+++LLP  VLLD +NLRWTLCA+DRCF NPVTSAFFRSVKVLPVSRGDGIYQ+                    GMDLAISKLN GGWVHIFPEG RSRDGGKT+GS KRGVGRLVLD D++P+VVPFVH+GMQ+IMP+GA+ PRIG  VTV+IGDPI FDD++  + +   +V R +LYDAV+SRIG RL E+KVQVD +A     Q Q+     T+R + ILQQVDWE FGM +    EDD    QET + L+    ++  Q   +D S+R GFS        MR ++DQ E + FAARGIF+N   +  +   R + PLKAW+++LEAN
Sbjct:    4 LDRGDVWKSKARSLQLQLRDRFRVAVDRHWRRRHNHHTFIPSADGYFSSTIQRWLSRFRDFRRDSLPSSTSFYRKRVIKDFSSEEDSTLVRMMQAVAVPVLGNVCHVFMNGLNSVQVYGLEKLHSALLQRPKGKPLLTVSNHVASMDDPLVIASLLPPSVLLDARNLRWTLCATDRCFKNPVTSAFFRSVKVLPVSRGDGIYQE--------------------GMDLAISKLNHGGWVHIFPEGSRSRDGGKTMGSSKRGVGRLVLDGDSMPLVVPFVHTGMQEIMPVGANFPRIGKMVTVLIGDPINFDDIIEFDKDKGSNVPRRRLYDAVASRIGDRLHEMKVQVDTIAIDQEMQLQDKSSHSTERTSKILQQVDWELFGMDSFMSVEDDSKQRQET-VALSNVSVSQHHQQSHSDQSWRAGFSYR------MRGYIDQMELVSFAARGIFLNNDTKNSARPSREMGPLKAWKQFLEAN 458          

Query:   16 VERGDLWKSKALSVQLRLRQRFRVEVDR--RLRHHPIF--SNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLL--NSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLA--XVTQPQNLPXXDTDRATVILQQVDWESFGMGNLTYSEDDGSAVQETE-IQLAAPPYTEEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEAN 1428
            ++RGD+WKSKA S+QL+ R RFRV VD   R RHH  F  S DGYFSST QR L RFRDFRRDSLPSST+FY KRV K+F++EE+S ++R +QAVAVPV+GNVCHVFMNGLNQVQVYG+EKLH A+L RPKGKPL+TVSNHVASMDDPLV+++LLP  VLLD +NLRWTLCA+DRCF NPVTSAFFRSVKVLPVSRGDGIYQ+                    GMDLA+SKLN GGWVHIFPEG RSRDGGKT+GS KRGVGRLVLD D++P+VVPFVH+GMQ+IMP+GA+ PRIG  VTV+IGDPI FDD+L  + E   +V R +L+DAV+SRIG RL E+KVQVD +A     Q Q+     TDR + ILQQVDWE FGM +    EDD    QET  ++  +     +   +D S+R GFS        MR ++DQ E + FAARGIFMN   +  +   R + PLKAW+++LEAN
Sbjct:    4 LDRGDVWKSKARSLQLQFRDRFRVAVDHHWRRRHHHTFIPSADGYFSSTIQRCLSRFRDFRRDSLPSSTSFYRKRVIKDFSSEEDSALVRTMQAVAVPVLGNVCHVFMNGLNQVQVYGLEKLHSALLHRPKGKPLLTVSNHVASMDDPLVIASLLPPSVLLDARNLRWTLCATDRCFKNPVTSAFFRSVKVLPVSRGDGIYQE--------------------GMDLALSKLNHGGWVHIFPEGSRSRDGGKTMGSSKRGVGRLVLDGDSMPLVVPFVHTGMQEIMPVGANFPRIGKMVTVLIGDPINFDDILEFDMEKGSNVPRRRLFDAVASRIGDRLHEMKVQVDTIAIEQEMQLQDNSSHSTDRTSEILQQVDWELFGMDSFMSVEDDSKQRQETVLLRNVSVSQHHQKSHSDQSWRAGFSYR------MRDYIDQMELVSFAARGIFMNNETKNSAGRSREMGPLKAWKQFLEAN 457          

Query:   13 RVERGDLWKSKALSVQLRLRQRFRVEVDR--RLRHHPIFSND--GYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLA--XVTQPQNLPXXDTDRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAAPPYTEEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFM-NRRAEEPSPSGRGVAPLKAWRRYLEAN 1428
            R++RGD+WK+KA S+QL+LR RFRV VDR  R RH+   S D  GYFSST QRWL R RDFRRDSLPSST+FY KRV ++F++EEES ILRM+QAVAVP++GNVCHVFMNGLN+VQVYG+EKLH A+L RPKGKPL+TVSNHVASMDDPLV+++LLP  VLL+ +NLRWTLCA+DRCF NPVTSAFFRSVKVLPV+RGDGIYQ+                    GMDLA+SKLN GGWVHIFPEG RSRDGGKT+GS KRGV R VLD D++P+V+PFVH+GMQ+IMPIGASIPRIG  VTV++GDPI FDD+LN E    V R +LYDAV++RIG RL ELK QVD LA    T+ Q+     ++R + ILQQVDWE FGM +   S DD S      + L     +E+ Q +  S RVGFS        MR +MDQ E M FAARG+FM N   ++ S   R + PLKAW+++ +A+
Sbjct:    3 RLDRGDVWKNKARSLQLQLRDRFRVAVDRHWRRRHNRTISPDADGYFSSTLQRWLNRIRDFRRDSLPSSTSFYRKRVMRDFSSEEESTILRMMQAVAVPILGNVCHVFMNGLNRVQVYGLEKLHTALLERPKGKPLLTVSNHVASMDDPLVIASLLPPQVLLNARNLRWTLCATDRCFKNPVTSAFFRSVKVLPVARGDGIYQE--------------------GMDLALSKLNNGGWVHIFPEGSRSRDGGKTMGSCKRGVARFVLDGDSMPVVIPFVHTGMQEIMPIGASIPRIGKMVTVIVGDPINFDDILNMEKGPDVPRKRLYDAVAARIGDRLYELKAQVDTLAMEQETRLQDRSPHSSERVSGILQQVDWELFGMNDFLSSADDDSMQTPETVVLPNTSVSEQHQQSH-SKRVGFSYR------MRGYMDQMELMSFAARGLFMNNNETKDSSGFSREIRPLKAWKQFFDAH 454          

Query:   16 VERGDLWKSKALSVQLRLRQRFRVEVDRRLRHHPIFSNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAXVTQPQNLPXXDT--DRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAAPPYTEEPQSADWSYRV---GFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRG-VAPLKAWRRYLEAN 1428
            V++ DLWKS AL + L+LR RFR+ VD       +FS DGYFSST  RW+ RFR+FRR+SLPS   FY +RV K+  AEEES + RMLQAVAVP+IGN CHVFMNG N+VQVYG+EKLHDA+L RPK KPL+TVSNHVAS+DDP V+++LLP  +LLD +NLRWTLCA+DRCF NPVTSAFFRSVKVLPVSRG+GIYQ+                    GMD+AISKLN GGWVHIFPEG RSRDGGKT+GS KRG+GRL+LDAD +PMVVPFVH+GMQDIMP+GAS+PRIG TVTV+IGDPI+F+D+L++EGAKHVSR  LYDAVSSRIG RL +LKVQVD+++   Q       +T  D A  IL +VDW+SFGMG     E   S++++              Q+ D ++R      S EGG++  ++ FMD +E MGFAARG+ MN        +  G + PLKAWR YLE N
Sbjct:    6 VDKADLWKS-ALLLNLKLRDRFRIAVDDHRGRAAVFSPDGYFSSTIHRWVTRFRNFRRESLPSPPAFYRRRVSKDLTAEEESALFRMLQAVAVPLIGNACHVFMNGFNRVQVYGLEKLHDALLNRPKNKPLVTVSNHVASVDDPFVIASLLPPKLLLDARNLRWTLCATDRCFKNPVTSAFFRSVKVLPVSRGEGIYQQ--------------------GMDIAISKLNSGGWVHIFPEGSRSRDGGKTMGSAKRGIGRLILDADTLPMVVPFVHTGMQDIMPVGASVPRIGKTVTVIIGDPIHFNDILSTEGAKHVSRKHLYDAVSSRIGQRLYDLKVQVDRVSLEQQSMLSHDANTSSDHAAEILHRVDWDSFGMGAQFSEESSASSIKQI------------AQTDDGNFRSPRRRVSSEGGVSLKIKKFMDSTEMMGFAARGLLMNEYKSWGESANVGQIRPLKAWREYLEVN 449          

Query:   16 VERGDLWKSKALSVQLRLRQRFRVEVDRRLRHHPIFSNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAXVTQPQNLPXXDT--DRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAAPPYTEEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEANRG 1434
            V++ DLWKS AL   L+LR RFR+ VD       +FS DG FSST  RW+ RFR+FRR+SLPS   FY +RV K+  AEEES + RMLQ VAVP+IGN CHVFMNG N+VQVYG+EKLHDA+L RPK KPL+TVSNHVAS+DDP V+++LLP   LLD +NLRWTLCA+DRCF NPVTSAF RSVKVLP+SRG+GIYQ+                    GMD+AISKLN GGWVHIFPEG RSRDGGKT+GS KRG+GRL+LDAD +PMVVPFVH+GMQDIMP+GAS+PRIG TVTV+IGDPI+F+D+L++EGA+HVSR  LYDAVSSRIG RL +LK QVD++    Q        T  DRA  I  +VDW+SFGMG   +SE+            ++ P  +       S +   S EGG++  ++  MD +E MGFAARG+ MN        +  G  PLKAWR Y   NRG
Sbjct:    6 VDKADLWKS-ALLFNLKLRDRFRIAVDDHRGRATVFSPDGCFSSTIHRWVTRFRNFRRESLPSPPAFYRRRVSKDLTAEEESALFRMLQTVAVPLIGNACHVFMNGFNRVQVYGLEKLHDALLNRPKNKPLVTVSNHVASVDDPFVIASLLPPKFLLDARNLRWTLCATDRCFKNPVTSAFSRSVKVLPISRGEGIYQQ--------------------GMDIAISKLNNGGWVHIFPEGSRSRDGGKTMGSAKRGIGRLILDADTLPMVVPFVHTGMQDIMPVGASVPRIGKTVTVIIGDPIHFNDILSTEGAQHVSRKHLYDAVSSRIGQRLYDLKAQVDRVYIEQQSMMSHNAKTPSDRAAEIFHRVDWDSFGMG-AQFSEESSP---------SSKPIGQSDDRIVRSPKRRVSPEGGVSLKIKKLMDSTEMMGFAARGLLMNEYKSRVESANVG-RPLKAWREYF-MNRG 447          

Query:   16 VERGDLWKSKALSVQLRLRQRFRVEVDRRLRHHPIFSNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAXVTQPQNLPXXDT--DRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAAPPYTEEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEANRG 1434
            V++ DLWKS AL   L+LR RFR+ VD                               D    +T         +  AEEES + RMLQ VAVP+IGN CHVFMNG N+VQVYG+EKLHDA+L RPK KPL+TVSNHVAS+DDP V+++LLP   LLD +NLRWTLCA+DRCF NPVTSAF RSVKVLP+SRG+GIYQ+                    GMD+AISKLN GGWVHIFPEG RSRDGGKT+GS KRG+GRL+LDAD +PMVVPFVH+GMQDIMP+GAS+PRIG TVTV+IGDPI+F+D+L++EGA+HVSR  LYDAVSSRIG RL +LK QVD++    Q        T  DRA  I  +VDW+SFGMG   +SE+            ++ P  +       S +   S EGG++  ++  MD +E MGFAARG+ MN        +  G  PLKAWR Y   NRG
Sbjct:    6 VDKADLWKS-ALLFNLKLRDRFRIAVD-------------------------------DHRGRAT---------DLTAEEESALFRMLQTVAVPLIGNACHVFMNGFNRVQVYGLEKLHDALLNRPKNKPLVTVSNHVASVDDPFVIASLLPPKFLLDARNLRWTLCATDRCFKNPVTSAFSRSVKVLPISRGEGIYQQ--------------------GMDIAISKLNNGGWVHIFPEGSRSRDGGKTMGSAKRGIGRLILDADTLPMVVPFVHTGMQDIMPVGASVPRIGKTVTVIIGDPIHFNDILSTEGAQHVSRKHLYDAVSSRIGQRLYDLKAQVDRVYIEQQSMMSHNAKTPSDRAAEIFHRVDWDSFGMG-AQFSEESSP---------SSKPIGQSDDRIVRSPKRRVSPEGGVSLKIKKLMDSTEMMGFAARGLLMNEYKSRVESANVG-RPLKAWREYF-MNRG 407          

Query:   28 DLWKSKALSVQLRLRQRFRVEVDRRLRHHPIFSNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLA--XVTQPQNLPXXDTDRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAA-PPYTEEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEAN 1428
            DLWKS+A S+QLRLR RFR+ VDR  R  P+FS DGYFSST QRWL+R RDFRRDSLPSS+ FY KRVGK+  AEE+S+ +RMLQA+AVPVIGNVC+VFM+GLN+VQVYG EKLH+ +L RP+ KPLITVSNHVASMDDPLV+++LLP  VLLD ++LRWT+CA+DRCF NPVTSAFF+ VKVLPVSRG+GIYQK                    GMD+A+SKLN GGWVHIFPEG RSRDGGKT+GS KRGVGRLVLDADN P+VVPFVH+GMQ++MPIGA+ PRIG  VTV+IGDPI+FDDLLN E  +H+SRGKLYDAVSSR+  RL+ELKVQVDKLA     Q QN     T+ A  IL QVDWESFGMG+   SEDD S+  E +  +      T+E   ++  + +GFS EGGI S +R +MD +E MGFAARG+F+NRRAEE   S + + PLKAW+++LEAN
Sbjct:    3 DLWKSRARSLQLRLRDRFRIAVDRH-RRLPMFSTDGYFSSTLQRWLRRVRDFRRDSLPSSSAFYRKRVGKDIGAEEDSVFVRMLQALAVPVIGNVCYVFMHGLNRVQVYGAEKLHEVLLHRPENKPLITVSNHVASMDDPLVIASLLPPSVLLDARSLRWTMCATDRCFKNPVTSAFFQCVKVLPVSRGEGIYQK--------------------GMDMAVSKLNSGGWVHIFPEGSRSRDGGKTMGSAKRGVGRLVLDADNTPIVVPFVHTGMQEVMPIGANFPRIGQAVTVLIGDPIHFDDLLNEEQTQHMSRGKLYDAVSSRVSRRLQELKVQVDKLALEHSIQLQNHDMQTTEWAAGILHQVDWESFGMGSYITSEDDSSSRLEIQSPMKLNVTNTQEHAPSERYFGMGFSYEGGIVSRIRGYMDPTELMGFAARGLFLNRRAEEKLASIQEIRPLKAWKQFLEAN 451          

Query:  388 RPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHII 645
            RPK KPLIT+SNHVASMDDPLV+++LLP   LL+ Q+LRWT+CA+DRCF NP+T AFFR VKVLPVS GDGIYQ +    VV + +
Sbjct:   21 RPKNKPLITLSNHVASMDDPLVIASLLPPSALLNAQSLRWTMCATDRCFKNPMTHAFFRCVKVLPVSLGDGIYQTYYIYLVVVYTL 106          

Query: 1501 LPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYYLQDLNLNVPISLGLRHEYLDIAGHCHGIICLTD-------YSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQS--TGIAVGFGYDXKAKDYKVVRIVMHFEGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQMYFKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVPESLQD--TKECYGSLAVWNGSIA-LFSVHVESGVRKSIGIWEMNDLDGSWTKHLTIVPIAGFGMPLTFW-NSDELVMVAADGRVVSHNFVTKMLKELPVSG 2553
            LP KS++RFRCV KSW    ++P F+ +HL ++   S  S+  +LFK        + S++ + SL        S++ + +   L VP+    + +Y  I G  +G+ICLT+        S  +FL NPA++E + LPK          IN   S    + +GF +     DYKVVRIV     +++      A+VY++ + SWR++  +I    +    S+ +  G  +W A    K  +D    +ILSF+M  ++F +I +P+   D   ++C   LA + GS++ LF     S     + + E   +  SWTKH TI       +P  F+ N + ++     G  +S N      ++L VSG
Sbjct:   32 LPVKSIVRFRCVCKSWCTLFDDPDFISMHLRQA---SANSNGRLLFKHL------SSSEQEIYSL-------RSNIAFAEVRRLEVPVP--SKTDYYQIVGSSNGLICLTESNFKGSYLSLNLFLWNPAIREFQTLPK--------YHINNFTSPLMVVGLGFAFHPVINDYKVVRIV-----YFMRNKTSEADVYSLRTGSWRKVDANI-CCYIHSNVSRTFINGALHWLA--GKKNEMDNTDNLILSFDMAKDVFKEIMLPDFGYDELIRKC---LADYKGSLSVLFYDAYHSNENCDVWVMEEYGVAKSWTKHFTIRHEIEIIIPFEFFDNGEAILQKKKSGGFISWNPDGIRFRDLGVSG 358          

Query: 1405 WRRYLEANRGEKQKMAGFCEMPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYYLQDLNLNVPISLGLRHEYLDIAGHCHGIICLTDYSE-------XVFLCNPAL-KESKLLPKSCLRLPPPKEINILQSTGIAV--GFGYDXKAKDYKVVRIVMHFEGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQMYFKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVPESLQDTKECYGSLAVWNG--SIALFSVHVESGVRKSIGIWEMND--LDGSWTKHLTIVPIAGFGMPLTFWNSDELVMVAADGRVVSHNFVTKMLKELPVSG 2553
            W+  L+        M+G   + E +V  +L  LP KS++RF+CV +SW    N+P F++++L ++I +    + C +  +Y+     + S++ + SL         D  + +   L VP+    + +Y  I G  +G+ICLT+ +          FL NP++  + K LPK  +        N++ S  + V  GF +  +  DYKVVRIV     +++    +   VY++  ++W+ I   +    +    S+ +  G  +W A     Q   ++  +ILSF+M ++   ++ +PE   D       LA + G  S+ +++ H       +  IW M++  +  SWTK  T        + L F ++ E+V+   +G +V+ +     +++L V+G
Sbjct:    8 WKEMLD------NSMSGNFILSENLV-DVLLRLPVKSIIRFKCVCQSWQTLFNDPDFINMNLRRAITH----NNCCMLLKYL-----SSSEEEVYSL-------RCDKDFAEFRRLQVPVP--SKTDYYHIVGSSNGLICLTESNNKGSYVTVDTFLWNPSVTAQWKPLPKYLIN-------NMMTSPFMVVGLGFAFHPQIDDYKVVRIV-----YFLKSKTYEVHVYSLKQDAWKNIDAKVHCH-IHDTVSRTFVNGALHWLAAK-KNQGRGKSDDLILSFDMVEDNLREMILPEFGYDESSTQKCLADYKGLLSVLVYNAH---RCNDNCDIWVMDEYGVASSWTKRFTFCLDVEILILLDFLDNGEVVVQNKNGGLVACDPNGGKIRDLKVAG 362          

Query: 1465 MPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYYLQDLNLNVPISLGLRHEYLD-IAGHCHGIICLTDYSEXVFLCNPALKESKLLP--KSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHFEGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVV--WCPSSQMYFKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVP 2262
            +PE +++ ILS LP KSL+RFRCV K+W   I++P FV+ HL +                          K+ ++ L+     +  D  +  DL +++ + LG+ ++    +   C+G++C+ D     +   P  K     P  + C  +P P  +           F YD  + DYK+VRI       ++       +++T+ +N WR ++ +  SSV+  W   S  YF G  +W A        DE   ++ +F++ +E F ++ +P
Sbjct:    4 IPEVIMVDILSRLPVKSLLRFRCVCKAWCTLISHPQFVETHLRQQ------------------------HKRPVIGLV--VPHSVDDPLHKDDLAVDLELHLGIPNKRTTTVLDSCNGLLCVVDCYYGFYSLKPPQKLILWNPSTRQCNHIPCPSFVGY---QNCMYSFFYDPGSDDYKIVRIFT-----FLGKDKTGIDIFTLKTNKWRRVE-ETHSSVIGYW---SATYFNGNLHWLAFRYGGYGEDERSSMV-AFSLREEKFQEMELP 235          

Query: 1462 EMPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILL--SLIDLCNXNNSD------VYYLQDLNLNVPISLGLRHEYLDIAGHCHGIICLTDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHFEGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQMYFKGFYYWFA----IXLDKQTLDENKKVILSFNMDDELFSDIPVPESLQDTKECYGSLAVWNGSIALFSVHVESGVRKSIGIWEMND--LDGSWTK 2409
            E+P  ++  IL  LP KSL+R RCV K+W   I++P FV  HL +      ++  C       LN  + G    L+  +    C   + D        YL D+        G ++E + +   C G++CL D +  + L NP+ ++       C +LPP    N+L   G   GFGYD  A DYKV  + M    F  +      +V+++ SN W+ I+    +      ++ ++  G  +W A    +  D          I++F+ + E F ++ +P   ++ +E Y  L V  G +    VH   G +    +W M +  +D SW+K
Sbjct:    3 ELPLHIIENILLRLPVKSLIRSRCVCKAWRTLISHPHFVKSHL-RLPQTQARTQFC------TLNYGEPGDNYYLVVGASTKDCEAFSDDNGGALAFDYLFDIG-------GFKYEVV-LLDSCDGLLCLVDLANKIVLWNPSTRQ-------CNQLPP--NPNVLDFLG-CHGFGYDSFADDYKVFLVSMLNPNFETV-----VDVFSLKSNKWKRIQEKHHTRAARMCATVLH--GALHWVAYDPILGFD---------TIMAFDFEKERFREMAIP---REEEELYVKLRVVGGCLC---VH---GSKDPSKMWVMKEYGVDTSWSK 282          

Query: 1465 MPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYYLQDLNLNVPISLGLRHEYLDIAGHCHGIICLTDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTG-IAVGFGYDXKAKDYKVVRIVMHFEGFWILFHPHXAEVYTMSSNSWREIK-------VDIPSSVVWCPSSQMYFKGF-----YYWFAIXLD 2181
            +P+ ++L+IL  LP KSLMRF+CV KSW + I++P F    L+ +  +S +    +   R +++      K   LS +          +Y        P+   + HEY +              ++ +F+ NP+ +E +       RLPP   I+ +Q    +A GFGYD  A DYKV R+  +  G    ++ +   V+++  N WR+I+        D P   V   +  + F G      YYW  + LD
Sbjct:   26 IPDEIILEILCLLPVKSLMRFKCVSKSWREMISDPDFEKKQLAVAARDSGE----VYNSRLIMHYPSMKLKSCPLSCL----------FY-------EPVGHSVNHEYPE--------------NDIIFVWNPSTREFR-------RLPP---ISFMQCFHLVAYGFGYDSIADDYKVTRVGCYCIG---RYYEYQVRVFSLRGNVWRKIENFPCYLFTDEPGIHV---NGSINFGGVGDSENYYWSVVGLD 226          

Query: 1462 EMPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSD-----VYYLQDLNLNVPISLGLRHEYLDIAGHCHGIICLTDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVM 2010
            E+P  ++  IL  LP KSL+RFRCV K+W   I++P FV  H  +      ++  CI+         DN S  +  S  D    +++D       YL D+          +HE + +   C G++C+ D +  + L NP+ ++   LP      P P   N++   G   GFGYD  A DYK+  + M
Sbjct:    3 ELPLHIIENILLRLPVKSLIRFRCVCKAWRTLISHPHFVRSHF-RLPQTQARTRLCII---DYSERGDNHSMVVRASTKDCEAFSDNDGGSLAFDYLFDIG-------KFKHEVV-LLDSCDGLLCIADLANKIVLWNPSTRQFNQLP------PNP---NVVDFVG-CHGFGYDSSADDYKIFVVSM 168          

Query:  571 KVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMP----IG--ASIPRIGNTVTVVIGDPIYFD 933
            K +P++RG GIYQ+                     M+ A+ +L+ G W+H FPEG  S++    I   K G   L++ A   P+V+P VH G++++MP    +G     P     + +V+G+PI FD
Sbjct:   30 KCIPITRGAGIYQEH--------------------MNEALERLSDGAWLHTFPEGKVSQE-DSPIRRLKWGTASLIVRAPVTPIVLPIVHHGLEEVMPENFFVGRRPPFPLWNKKIKIVVGEPIEFD 135          

Query: 1840 EXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHFEGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQMYFKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVPESLQDTKECYGSLAVWNGSIALFSVHVESGVRKSIGIWEMND--LDGSWTKHLTIV----PI-AGFGMPLTFWNSDELVMVAADGRVVSHNFVTKMLKELPVSGVFLERFQAFVYVYSLVS 2604
            + +F+ NP++KESK LP       P +++  L    ++  FGYD    DYKVVR+V         +H    EV+++ SN+WR+I+   P   ++   +  +  G   W A+  DK   + +   I S ++  E +  +P P+   +T +    + V  G   +   + +      I +W M +  +  SW+K +T+     P+ A +  PL F+  +  +++   G ++ +NF         + GV     +  VY+ S+VS
Sbjct:    4 DTIFVWNPSIKESKRLPSK-----PFEQLFYL----VSYAFGYDSITDDYKVVRLVCCSINDSYEYH---VEVFSLRSNAWRKIR-SFP-YFLFTDEAGKHVNGSINW-AVSRDK---NNDHWFIASLDLATESYEVVPQPDCANETLK--PIIRVLGGQFCIIFEYDD-----IIDVWVMQEYGVKESWSKLVTVPFFSDPLDANYAKPL-FYLKEGAILIDFYGMLILYNFNRNESTSPMIYGVH-HYHEVEVYLESMVS 238          

Query:  274 MLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGAS-IPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAXVTQP 1065
            +  +V + ++G     +   +N + V+  E L++ +  R    PLITVSNH + MDDP +   L  RH+  +++ +RWT  A+D CF+  + S FF   K +PV RGDG+YQK                    GMD  + KLN G WVHIFPEG  +          K G+GRL+ +    P+++P  H GM D++P      PR G  +TV+IG P     +L    A++ S  ++  A++  I    + LK Q ++L    QP
Sbjct:   19 LASSVVMGLVGTYSCFWTKYMNHLTVHNKEVLYELIENRGPATPLITVSNHQSCMDDPHLWGILKLRHIW-NLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGDGVYQK--------------------GMDFILEKLNHGDWVHIFPEGKVNM--SSEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFSALPILERLRAENKSAVEMRKALTDFIQEEFQRLKTQAEQLHNHLQP 260          

Query:  274 MLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGAS-IPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAXVTQP 1065
            +  +V + ++G     +   +N + V+  E L++ +  R    PLITVSNH + MDDP +   L  RH+  +++ +RWT  A+D CF+  + S FF   K +PV RGDG+YQK                    GMD  + KLN G WVHIFPEG  +          K G+GRL+ +    P+++P  H GM D++P      PR G  +TV+IG P     +L    A++ S  ++  A++  I    + LK Q ++L    QP
Sbjct:   19 LASSVVMGLVGTYSCFWTKYMNHLTVHNKEVLYELIENRGPATPLITVSNHQSCMDDPHLWGILKLRHIW-NLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGDGVYQK--------------------GMDFILEKLNHGDWVHIFPEGKVNM--SSEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFSALPVLERLRAENKSAVEMRKALTDFIQEEFQRLKTQAEQLHNHLQP 260          

Query:  274 MLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGAS-IPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAXVTQP 1065
            +  +V + ++G     +   +N + V+  E L++ +  R    PLITVSNH + MDDP +   L  RH+  +++ +RWT  A+D CF+  + S FF   K +PV RGDG+YQK                    GMD  + KLN G WVHIFPEG  +          K G+GRL+ +    P+++P  H GM D++P      PR G  +TV+IG P     +L    A++ S  ++  A++  I    + LK Q ++L    QP
Sbjct:   19 LASSVVMGLVGTYSCFWTKYMNHLTVHNKEVLYELIENRGPATPLITVSNHQSCMDDPHLWGILKLRHIW-NLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGDGVYQK--------------------GMDFILEKLNHGDWVHIFPEGKVNM--SSEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFSALPVLERLRAENKSAVEMRKALTDFIQEEFQRLKTQAEQLHNHLQP 260          

Query:  292 VPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMP-IGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKL 1047
            V  +G    V +  LN+ +VY  E+L   + +RPKG PL+TVSNH +  DDP  L   LP  ++ +   +RW++ A D CF+N + S FF   K +PV RG G+Y                    Q  ++L I K   G W+H+FPEG  + D  K     K GVGR++ ++  IP+++P  H GM D++P +   + + G  VT+ +G P+  +D +     + V        ++ +I    R+L+ + +KL
Sbjct:  144 VSAVGIFSKVVLMFLNKPRVYNRERLIQLITKRPKGIPLVTVSNHYSCFDDP-GLWGCLPLGIVCNTYKIRWSMAAHDICFTNKLHSLFFMFGKCIPVVRGIGVY--------------------QDAINLCIEKAALGHWIHVFPEGKVNMD--KEELRLKWGVGRIIYESPKIPIILPMWHEGMDDLLPNVEPYVIQRGKQVTLNVGQPLDLNDFILDLKKRQVPEPTARKLITDKIQEAFRDLRAETEKL 373          

Query:  274 MLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVV----THIIANKTKR------LQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGAS-IPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAXVTQP 1065
            +  +V + ++G     +   +N + V+  E L++ + +R    PLITVSNH + MDDP +   L  RH+  +++ +RWT  A+D CF+  + S FF   K +PV RG   +Q       V     H+     +R       Q GMD  + KLN G WVHIFPEG  +          K G+GRL+ +    P+++P  H GM D++P      PR G  +TV+IG P     +L    A++ S  ++  A++  I    + LK Q ++L    QP
Sbjct:   19 LASSVVMGLVGTYSCFWTKYMNHLTVHNREVLYELIEKRGPATPLITVSNHQSCMDDPHLWGILKLRHI-WNLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGAEFFQAENEGKGVLDTGRHMPGAGKRREKGDGVYQKGMDFILEKLNHGDWVHIFPEGKVNM--SSEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFSALPVLERLRAENKSAVEMRKALTDFIQEEFQHLKTQAEQLHNHLQP 290          

Query:  274 MLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVV----THIIANKTKR------LQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGAS-IPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAXVTQP 1065
            +  +V + ++G     +   +N + V+  E L++ +  R    PLITVSNH + MDDP +   L  RH+  +++ +RWT  A+D CF+  + S FF   K +PV RG   +Q       V     H+     +R       Q GMD  + KLN G WVHIFPEG  +          K G+GRL+ +    P+++P  H GM D++P      PR G  +TV+IG P     +L    A++ S  ++  A++  I    + LK Q ++L    QP
Sbjct:   19 LASSVVMGLVGTYSCFWTKYMNHLTVHNKEVLYELIENRGPATPLITVSNHQSCMDDPHLWGILKLRHI-WNLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGAEFFQAENEGKGVLDTGRHMPGAGKRREKGDGVYQKGMDFILEKLNHGDWVHIFPEGKVNM--SSEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFSALPVLERLRAENKSAVEMRKALTDFIQEEFQHLKTQAEQLHNHLQP 290          

Query:  274 MLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVV----THIIANKTKR------LQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGAS-IPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAXVTQP 1065
            +  +V + ++G     +   +N + V+  E L++ +  R    PLITVSNH + MDDP +   L  RH+  +++ +RWT  A+D CF+  + S FF   K +PV RG   +Q       V     H+     +R       Q GMD  + KLN G WVHIFPEG  +          K G+GRL+ +    P+++P  H GM D++P      PR G  +TV+IG P     +L    A++ S  ++  A++  I    + LK Q ++L    QP
Sbjct:   19 LASSVVMGLVGTYSCFWTKYMNHLTVHNKEVLYELIENRGPATPLITVSNHQSCMDDPHLWGILKLRHI-WNLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGAEFFQAENEGKGVLDTGRHMPGAGKRREKGDGVYQKGMDFILEKLNHGDWVHIFPEGKVNM--SSEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFSALPVLERLRAENKSAVEMRKALTDFIQEEFQRLKTQAEQLHNHLQP 290          

Query:  274 MLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVV----THIIANKTKR------LQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGAS-IPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAXVTQP 1065
            +  +V + ++G     +   +N + V+  E L++ +  R    PLITVSNH + MDDP +   L  RH+  +++ +RWT  A+D CF+  + S FF   K +PV RG   +Q       V     H+     +R       Q GMD  + KLN G WVHIFPEG  +          K G+GRL+ +    P+++P  H GM D++P      PR G  +TV+IG P     +L    A++ S  ++   ++  I    + LK Q ++L    QP
Sbjct:   19 LASSVVMGLVGTYSCFWTKYMNHLTVHNKEVLYELIENRGPATPLITVSNHQSCMDDPHLWGILKLRHI-WNLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGAEFFQPENEGKGVLDTGRHMPGAGKRREKGDGVYQKGMDFILEKLNHGDWVHIFPEGKVNM--SSEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFSALPVLERLRAENKSAVEMRKVLTDFIQEEFQRLKTQAEQLHNHLQP 290          

Query:  298 VIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGK-PLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADN----IPMVVPFVHSGMQDIMPIG-ASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYD 987
            ++G +C  +++ +N V   G++KL + + +  + K P+IT++NH +++DDPL+   +LP  +L+D    RWTL AS+  F+N   S FF   K + + RGDGIY                    Q GM+ +I +L++G W+HIFPEG  S+     +   K G+GRLV +       +P+VVP  H GM+  MP+    IPR+G  + + +GD IY D ++    +K++   K+ D
Sbjct:   32 LVGVLCKFWIS-MNTVTTSGIDKLVNEIDKTHQLKRPMITIANHSSNLDDPLLWG-VLPNRILMDPSKQRWTLGASNILFTNWFYSKFFSLGKCIKIVRGDGIY--------------------QDGMNESIDRLSEGQWLHIFPEGRISQQ--TQLLYFKWGLGRLVGECYRRTGVVPLVVPIYHQGMEKSMPLAKLPIPRVGINLDIKVGDNIYCDQVI----SKYIDDNKISD 239          

Query: 1405 WRRYLEANRGEKQKMA--GFCEMPEAMVL------QILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVL----------NDADNGSKKILL-----------SLIDLCNXNNSDVYYLQDLNLNVPISL-GLRHEYLDIAGHCHGIICLTDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHFEGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQMYFKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVPESLQDTKECYGSLAVWNGSIALFSVHVESGVRKSIGIWEMNDLD--GSWTKHLTIVPIAGFGMPLTFWNSDELVMVAADGRVVSHNFVTKMLKELPVSGVFL-ERFQAFVYVYSLVS 2604
            W   +EA + E+++    G    PE++VL      +IL  LP KS+ RFRCV K +    ++P F  +HL   + N    S   L ++ ++          N   +G + +             S+      N    +   D  + + ++    R  +++I G  +G++C++     VFL NP   +SK LP++      PK +   +      GFG+D    DYK+V++V   E          A VY++ ++SWR I      ++ +  +   Y  G ++  AI         N++V+++F++  E F ++PVP+  +D    + +  V  GS+      V S       IW M++     SW++ + I  +     PL    +DE V++  DG +V +NF T     L + GV L + F+A  YV SL+S
Sbjct:    8 WEAIMEATKRERRREDDDGEKASPESLVLPPEIITEILLRLPAKSIGRFRCVSKLFCTLSSDPGFAKIHLDLILRNESVRS---LHRKLIVSSHNLYSLDFNSIGDGIRDLAAVEHNYPLKDDPSIFSEMIRNYVGDHLYDDRRVMLKLNAKSYRRNWVEIVGSSNGLVCISPGEGAVFLYNPTTGDSKRLPENF----RPKSVEYERDNFQTYGFGFDGLTDDYKLVKLVATSEDIL------DASVYSLKADSWRRI-----CNLNYEHNDGSYTSGVHFNGAIHWVFTESRHNQRVVVAFDIQTEEFREMPVPDEAEDCSHRFSNFVV--GSLNGRLCVVNSCYDVHDDIWVMSEYGEAKSWSR-IRINLLYRSMKPLCSTKNDEEVLLELDGDLVLYNFETNASSNLGICGVKLSDGFEANTYVESLIS 419          

Query:   28 DLWKSKALSVQLRLRQRFRVEVDRRLRHHPIFSNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLA--XVTQPQNLPXXDTDRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAA-PPYTEEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEAN 1428
            DLWKS+A S+QLRLR RFR+ VDR  R  P+FS DGYFSST QRWL+R RDFRRDSLPSS+ FY KRVGK+  AEE+S+ +RMLQA+AVPVIGNVC+VFM+GLN+VQVYG EKLH+ +L RP+ KPLITVSNHVAS+DDPLV+++LLP  VLLD ++LRWT+CA+DRCF NPVTSAFF+ VKVLPVSRG+GIYQK                    GMD+A+SKLN GGWVHIFPEG RSRDGGKT+GS KRGVGRLVLDADN P+VVPFVH+GMQ++MPIGA+ PRIG  VTV+IGDPI+FDDLLN +  +H+SRGKLYDAVSSR+ HRL+ELKVQVDKLA     Q QN     T+RA  IL QVDWESFGMG+   SE+D S+  E +  +      T+E   ++  + +GFS EGGI S +R +MD +E MGFAARG+F+NRRAEE   S + + PLKAW+++LEAN
Sbjct:    3 DLWKSRARSLQLRLRDRFRIAVDRH-RRLPMFSTDGYFSSTLQRWLRRVRDFRRDSLPSSSAFYRKRVGKDIGAEEDSVFVRMLQALAVPVIGNVCYVFMHGLNRVQVYGAEKLHEVLLHRPENKPLITVSNHVASVDDPLVIASLLPPSVLLDARSLRWTMCATDRCFKNPVTSAFFQCVKVLPVSRGEGIYQK--------------------GMDMAVSKLNSGGWVHIFPEGSRSRDGGKTMGSAKRGVGRLVLDADNTPIVVPFVHTGMQEVMPIGANFPRIGQAVTVLIGDPIHFDDLLNEQQTQHMSRGKLYDAVSSRVSHRLQELKVQVDKLALEHSIQLQNHDMQTTERAAGILHQVDWESFGMGSYITSENDSSSRLEIQSPMKLNVTNTQEHAPSERYFGMGFSYEGGIVSRIRGYMDPTELMGFAARGLFLNRRAEEKLASIQEIRPLKAWKQFLEAN 451          

Query:   28 DLWKSKALSVQLRLRQRFRVEVDRRLRHHPIFSNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLA--XVTQPQNLPXXDTDRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAA-PPYTEEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEAN 1428
            DLWKS+A S+QLRLR RFR+ VDR  R  P+FS DGYFSST QRWL+R RDFRRDSLPSS+ FY KRVGK+  AEE+S+ +RMLQA+AVPVIGNVC+VFM+GLN+VQVYG EKLH+ +L RP+ KPLITVSNHVASMDDPLV+++LLP  VLLD ++LRWT+CA+DRCF NPVTSAFF+ VKVLPVSRG+GIYQK                    GMD+A+SKLN GGWVHIFPEG RSRDGGKT+GS KRGVGRLVLDADN P+VVPFVH+GMQ++MPIGA+ PRIG  VTV+IGDPI+FDDLLN E  +H+SRGKLYDAVSSR+  RL+ELKVQVDKLA     Q QN     T+ A  IL QVDWESFGMG+   SEDD S+  E +  +      T+E   ++  + +GFS EGGI S +R +MD +E MGFAARG+F+NRRAEE   S + + PLKAW+++LEAN
Sbjct:    3 DLWKSRARSLQLRLRDRFRIAVDRH-RRLPMFSTDGYFSSTLQRWLRRVRDFRRDSLPSSSAFYRKRVGKDIGAEEDSVFVRMLQALAVPVIGNVCYVFMHGLNRVQVYGAEKLHEVLLHRPENKPLITVSNHVASMDDPLVIASLLPPSVLLDARSLRWTMCATDRCFKNPVTSAFFQCVKVLPVSRGEGIYQK--------------------GMDMAVSKLNSGGWVHIFPEGSRSRDGGKTMGSAKRGVGRLVLDADNTPIVVPFVHTGMQEVMPIGANFPRIGQAVTVLIGDPIHFDDLLNEEQTQHMSRGKLYDAVSSRVSRRLQELKVQVDKLALEHSIQLQNHDMQTTEWAAGILHQVDWESFGMGSYITSEDDSSSRLEIQSPMKLNVTNTQEHAPSERYFGMGFSYEGGIVSRIRGYMDPTELMGFAARGLFLNRRAEEKLASIQEIRPLKAWKQFLEAN 451          

Query:    1 MAAARVERGDLWKSKALSVQLRLRQRFRVEVDRRLRHHPIFSNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAXVTQPQNLPXXDTDRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAAPPYT--EEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEAN 1428
            MA  R+ER DLWKSKA  +QLRLR RFRV VDR  R  PI+ +D YF S  QRW+ RFRDFR  SL S + FY KRV +EFNAEEES+I+RMLQ+VAVP+IGN+C+VFMNGLN+VQVYG+EKLHDA+L RP+ KPL+TVSNHVAS+DDP V+++LLP  VL+D QNLRWTLCA+DRCF NPVTSAFFRSVKVLPVSRGDGIYQK                    GMD+AI+KLN GGWVHIFPEG RSRDGGKT+GS KRGVGRL+LDAD +PMV+PFVH+GMQ+IMPIGA  PRIG TVTV++GDPI FDDL N+E  + VSRGKLYDAV+SRIG +L ELKVQV+ LA     ++     T+RA  IL QVDW+SFGMG+    +DD S   ++EI L  P +T  +EP S+D  +R   S E GI S M  FMD +E + FAA+G+FMN R +E   S   V+P++AWR YL AN
Sbjct:    1 MAVHRIERADLWKSKARILQLRLRDRFRVAVDRHRRRPPIYLDDDYFLSKVQRWITRFRDFREGSLHSRSAFYRKRVSREFNAEEESVIIRMLQSVAVPLIGNMCYVFMNGLNRVQVYGLEKLHDALLHRPRNKPLLTVSNHVASVDDPFVIASLLPPGVLMDAQNLRWTLCATDRCFRNPVTSAFFRSVKVLPVSRGDGIYQK--------------------GMDMAIAKLNSGGWVHIFPEGSRSRDGGKTMGSSKRGVGRLILDADTVPMVIPFVHTGMQEIMPIGAKFPRIGKTVTVLVGDPIIFDDLFNAEEREQVSRGKLYDAVASRIGSQLLELKVQVENLAFQQSIKHQHPSATERAADILHQVDWDSFGMGSHVIRKDDTS---DSEI-LPKPNFTSHQEPISSDGYFRTRSSPEVGIISRMHSFMDSTELLSFAAKGLFMNLRRKENRSSFGDVSPVRAWRHYLLAN 454          

Query:    1 MAAARVE--RGDLWKSKALSVQLRLRQRFRVEVDRRLRHHPIFS--NDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLA--XVTQPQNLPXXDTDRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAAPPYTEEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEAN 1428
            MA  R+E  RGDLWKSKA ++QLRLR RFRV VDR  R   IFS  +DGYFSST QRWL  FRDFRRDSL S + FY KRV K+FNA+EES+I+RM+Q+VAVP++GN+CHVFM+GLN+VQVYGVEKLHDA+L RPK KPL+TVSNHVAS+DDP ++++LLP  VL+D QNLRWTLCASDRCF NPV+SAFF+SVKVLPV+RG+GIYQK                    GMD+AI+KLN G WVHIFPEG RSRDGGKT+GS KRGVGRL+LDAD +P+V+PFVH+GMQ+IMPIGA++PRIG  VTV++GDPI+FDD+L++EG +++SRGK+YDAVSSRIG RL++LKVQV+KLA     + Q      T+RA  +LQQVDW SFG G+   +E+     +        P  ++E  S+   +R+GFS +  I S MR +MD +E +GFAARG+FMN RA E + S R V P++AW+++LEAN
Sbjct:    1 MAVQRIELGRGDLWKSKAKALQLRLRDRFRVVVDRHRRRPHIFSAASDGYFSSTVQRWLNHFRDFRRDSLHSHSAFYRKRVSKDFNADEESVIIRMVQSVAVPLLGNMCHVFMHGLNRVQVYGVEKLHDALLHRPKNKPLLTVSNHVASVDDPFIIASLLPPSVLMDAQNLRWTLCASDRCFKNPVSSAFFQSVKVLPVARGEGIYQK--------------------GMDMAIAKLNSGSWVHIFPEGSRSRDGGKTMGSSKRGVGRLILDADTVPLVIPFVHTGMQEIMPIGATLPRIGKRVTVLLGDPIHFDDILDAEGVENISRGKMYDAVSSRIGQRLQQLKVQVEKLALEQSVEFQQAAAGITERAADMLQQVDWGSFGAGSHVSTEERDLPCE--------PRPSQELLSSGRYFRIGFSYDSIIISRMRGYMDSTELLGFAARGLFMNFRAREHTASIRDVGPVRAWKQFLEAN 454          

Query:   16 VERGDLWKSKALSVQLRLRQRFRVEVDRRLR----HHPIF-SNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLL--NSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLA--XVTQPQNLPXXDTDRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAAPPYTEEPQS--ADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEAN 1428
            ++RGD+WKSKA S+QL+LR RFRV VDR  R    HH    S DGYFSST QRWL RFRDFRRDSLPSST+FY KRV K+F++EE+S ++RM+QAVAVPV+GNVCHVFMNGLN VQVYG+EKLH A+L+RPKGKPL+TVSNHVASMDDPLV+++LLP  VLLD +NLRWTLCA+DRCF NPVTSAFFRSVKVLPVSRGDGIYQ+                    GMDLAISKLN GGWVHIFPEG RSRDGGKT+GS KRGVGRLVLD D++P+VVPFVH+GMQ+IMP+GA+ PRIG  VTV+IGDPI FDD++  + +   +V R +LYDAV+SRIG RL E+KVQVD +A     Q Q+     T+R + ILQQVDWE FGM +    EDD    QET + L+    ++  Q   +D S+R GFS        MR ++DQ E + FAARGIF+N   +  +   R + PLKAW+++LEAN
Sbjct:    4 LDRGDVWKSKARSLQLQLRDRFRVAVDRHWRRRHNHHTFIPSADGYFSSTIQRWLSRFRDFRRDSLPSSTSFYRKRVIKDFSSEEDSTLVRMMQAVAVPVLGNVCHVFMNGLNSVQVYGLEKLHSALLQRPKGKPLLTVSNHVASMDDPLVIASLLPPSVLLDARNLRWTLCATDRCFKNPVTSAFFRSVKVLPVSRGDGIYQE--------------------GMDLAISKLNHGGWVHIFPEGSRSRDGGKTMGSSKRGVGRLVLDGDSMPLVVPFVHTGMQEIMPVGANFPRIGKMVTVLIGDPINFDDIIEFDKDKGSNVPRRRLYDAVASRIGDRLHEMKVQVDTIAIDQEMQLQDKSSHSTERTSKILQQVDWELFGMDSFMSVEDDSKQRQET-VALSNVSVSQHHQQSHSDQSWRAGFSYR------MRGYIDQMELVSFAARGIFLNNDTKNSARPSREMGPLKAWKQFLEAN 458          

Query:   16 VERGDLWKSKALSVQLRLRQRFRVEVDR--RLRHHPIF--SNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLL--NSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLA--XVTQPQNLPXXDTDRATVILQQVDWESFGMGNLTYSEDDGSAVQETE-IQLAAPPYTEEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEAN 1428
            ++RGD+WKSKA S+QL+ R RFRV VD   R RHH  F  S DGYFSST QR L RFRDFRRDSLPSST+FY KRV K+F++EE+S ++R +QAVAVPV+GNVCHVFMNGLNQVQVYG+EKLH A+L RPKGKPL+TVSNHVASMDDPLV+++LLP  VLLD +NLRWTLCA+DRCF NPVTSAFFRSVKVLPVSRGDGIYQ+                    GMDLA+SKLN GGWVHIFPEG RSRDGGKT+GS KRGVGRLVLD D++P+VVPFVH+GMQ+IMP+GA+ PRIG  VTV+IGDPI FDD+L  + E   +V R +L+DAV+SRIG RL E+KVQVD +A     Q Q+     TDR + ILQQVDWE FGM +    EDD    QET  ++  +     +   +D S+R GFS        MR ++DQ E + FAARGIFMN   +  +   R + PLKAW+++LEAN
Sbjct:    4 LDRGDVWKSKARSLQLQFRDRFRVAVDHHWRRRHHHTFIPSADGYFSSTIQRCLSRFRDFRRDSLPSSTSFYRKRVIKDFSSEEDSALVRTMQAVAVPVLGNVCHVFMNGLNQVQVYGLEKLHSALLHRPKGKPLLTVSNHVASMDDPLVIASLLPPSVLLDARNLRWTLCATDRCFKNPVTSAFFRSVKVLPVSRGDGIYQE--------------------GMDLALSKLNHGGWVHIFPEGSRSRDGGKTMGSSKRGVGRLVLDGDSMPLVVPFVHTGMQEIMPVGANFPRIGKMVTVLIGDPINFDDILEFDMEKGSNVPRRRLFDAVASRIGDRLHEMKVQVDTIAIEQEMQLQDNSSHSTDRTSEILQQVDWELFGMDSFMSVEDDSKQRQETVLLRNVSVSQHHQKSHSDQSWRAGFSYR------MRDYIDQMELVSFAARGIFMNNETKNSAGRSREMGPLKAWKQFLEAN 457          

Query:   13 RVERGDLWKSKALSVQLRLRQRFRVEVDR--RLRHHPIFSND--GYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLA--XVTQPQNLPXXDTDRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAAPPYTEEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFM-NRRAEEPSPSGRGVAPLKAWRRYLEAN 1428
            R++RGD+WK+KA S+QL+LR RFRV VDR  R RH+   S D  GYFSST QRWL R RDFRRDSLPSST+FY KRV ++F++EEES ILRM+QAVAVP++GNVCHVFMNGLN+VQVYG+EKLH A+L RPKGKPL+TVSNHVASMDDPLV+++LLP  VLL+ +NLRWTLCA+DRCF NPVTSAFFRSVKVLPV+RGDGIYQ+                    GMDLA+SKLN GGWVHIFPEG RSRDGGKT+GS KRGV R VLD D++P+V+PFVH+GMQ+IMPIGASIPRIG  VTV++GDPI FDD+LN E    V R +LYDAV++RIG RL ELK QVD LA    T+ Q+     ++R + ILQQVDWE FGM +   S DD S      + L     +E+ Q +  S RVGFS        MR +MDQ E M FAARG+FM N   ++ S   R + PLKAW+++ +A+
Sbjct:    3 RLDRGDVWKNKARSLQLQLRDRFRVAVDRHWRRRHNRTISPDADGYFSSTLQRWLNRIRDFRRDSLPSSTSFYRKRVMRDFSSEEESTILRMMQAVAVPILGNVCHVFMNGLNRVQVYGLEKLHTALLERPKGKPLLTVSNHVASMDDPLVIASLLPPQVLLNARNLRWTLCATDRCFKNPVTSAFFRSVKVLPVARGDGIYQE--------------------GMDLALSKLNNGGWVHIFPEGSRSRDGGKTMGSCKRGVARFVLDGDSMPVVIPFVHTGMQEIMPIGASIPRIGKMVTVIVGDPINFDDILNMEKGPDVPRKRLYDAVAARIGDRLYELKAQVDTLAMEQETRLQDRSPHSSERVSGILQQVDWELFGMNDFLSSADDDSMQTPETVVLPNTSVSEQHQQSH-SKRVGFSYR------MRGYMDQMELMSFAARGLFMNNNETKDSSGFSREIRPLKAWKQFFDAH 454          

Query:   16 VERGDLWKSKALSVQLRLRQRFRVEVDRRLRHHPIFSNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAXVTQPQNLPXXDT--DRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAAPPYTEEPQSADWSYRV---GFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRG-VAPLKAWRRYLEAN 1428
            V++ DLWKS AL + L+LR RFR+ VD       +FS DGYFSST  RW+ RFR+FRR+SLPS   FY +RV K+  AEEES + RMLQAVAVP+IGN CHVFMNG N+VQVYG+EKLHDA+L RPK KPL+TVSNHVAS+DDP V+++LLP  +LLD +NLRWTLCA+DRCF NPVTSAFFRSVKVLPVSRG+GIYQ+                    GMD+AISKLN GGWVHIFPEG RSRDGGKT+GS KRG+GRL+LDAD +PMVVPFVH+GMQDIMP+GAS+PRIG TVTV+IGDPI+F+D+L++EGAKHVSR  LYDAVSSRIG RL +LKVQVD+++   Q       +T  D A  IL +VDW+SFGMG     E   S++++              Q+ D ++R      S EGG++  ++ FMD +E MGFAARG+ MN        +  G + PLKAWR YLE N
Sbjct:    6 VDKADLWKS-ALLLNLKLRDRFRIAVDDHRGRAAVFSPDGYFSSTIHRWVTRFRNFRRESLPSPPAFYRRRVSKDLTAEEESALFRMLQAVAVPLIGNACHVFMNGFNRVQVYGLEKLHDALLNRPKNKPLVTVSNHVASVDDPFVIASLLPPKLLLDARNLRWTLCATDRCFKNPVTSAFFRSVKVLPVSRGEGIYQQ--------------------GMDIAISKLNSGGWVHIFPEGSRSRDGGKTMGSAKRGIGRLILDADTLPMVVPFVHTGMQDIMPVGASVPRIGKTVTVIIGDPIHFNDILSTEGAKHVSRKHLYDAVSSRIGQRLYDLKVQVDRVSLEQQSMLSHDANTSSDHAAEILHRVDWDSFGMGAQFSEESSASSIKQI------------AQTDDGNFRSPRRRVSSEGGVSLKIKKFMDSTEMMGFAARGLLMNEYKSWGESANVGQIRPLKAWREYLEVN 449          

Query:   16 VERGDLWKSKALSVQLRLRQRFRVEVDRRLRHHPIFSNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAXVTQPQNLPXXDT--DRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAAPPYTEEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEANRG 1434
            V++ DLWKS AL   L+LR RFR+ VD       +FS DG FSST  RW+ RFR+FRR+SLPS   FY +RV K+  AEEES + RMLQ VAVP+IGN CHVFMNG N+VQVYG+EKLHDA+L RPK KPL+TVSNHVAS+DDP V+++LLP   LLD +NLRWTLCA+DRCF NPVTSAF RSVKVLP+SRG+GIYQ+                    GMD+AISKLN GGWVHIFPEG RSRDGGKT+GS KRG+GRL+LDAD +PMVVPFVH+GMQDIMP+GAS+PRIG TVTV+IGDPI+F+D+L++EGA+HVSR  LYDAVSSRIG RL +LK QVD++    Q        T  DRA  I  +VDW+SFGMG   +SE+            ++ P  +       S +   S EGG++  ++  MD +E MGFAARG+ MN        +  G  PLKAWR Y   NRG
Sbjct:    6 VDKADLWKS-ALLFNLKLRDRFRIAVDDHRGRATVFSPDGCFSSTIHRWVTRFRNFRRESLPSPPAFYRRRVSKDLTAEEESALFRMLQTVAVPLIGNACHVFMNGFNRVQVYGLEKLHDALLNRPKNKPLVTVSNHVASVDDPFVIASLLPPKFLLDARNLRWTLCATDRCFKNPVTSAFSRSVKVLPISRGEGIYQQ--------------------GMDIAISKLNNGGWVHIFPEGSRSRDGGKTMGSAKRGIGRLILDADTLPMVVPFVHTGMQDIMPVGASVPRIGKTVTVIIGDPIHFNDILSTEGAQHVSRKHLYDAVSSRIGQRLYDLKAQVDRVYIEQQSMMSHNAKTPSDRAAEIFHRVDWDSFGMG-AQFSEESSP---------SSKPIGQSDDRIVRSPKRRVSPEGGVSLKIKKLMDSTEMMGFAARGLLMNEYKSRVESANVG-RPLKAWREYF-MNRG 447          

Query:   16 VERGDLWKSKALSVQLRLRQRFRVEVDRRLRHHPIFSNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAXVTQPQNLPXXDT--DRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAAPPYTEEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEANRG 1434
            V++ DLWKS AL   L+LR RFR+ VD                               D    +T         +  AEEES + RMLQ VAVP+IGN CHVFMNG N+VQVYG+EKLHDA+L RPK KPL+TVSNHVAS+DDP V+++LLP   LLD +NLRWTLCA+DRCF NPVTSAF RSVKVLP+SRG+GIYQ+                    GMD+AISKLN GGWVHIFPEG RSRDGGKT+GS KRG+GRL+LDAD +PMVVPFVH+GMQDIMP+GAS+PRIG TVTV+IGDPI+F+D+L++EGA+HVSR  LYDAVSSRIG RL +LK QVD++    Q        T  DRA  I  +VDW+SFGMG   +SE+            ++ P  +       S +   S EGG++  ++  MD +E MGFAARG+ MN        +  G  PLKAWR Y   NRG
Sbjct:    6 VDKADLWKS-ALLFNLKLRDRFRIAVD-------------------------------DHRGRAT---------DLTAEEESALFRMLQTVAVPLIGNACHVFMNGFNRVQVYGLEKLHDALLNRPKNKPLVTVSNHVASVDDPFVIASLLPPKFLLDARNLRWTLCATDRCFKNPVTSAFSRSVKVLPISRGEGIYQQ--------------------GMDIAISKLNNGGWVHIFPEGSRSRDGGKTMGSAKRGIGRLILDADTLPMVVPFVHTGMQDIMPVGASVPRIGKTVTVIIGDPIHFNDILSTEGAQHVSRKHLYDAVSSRIGQRLYDLKAQVDRVYIEQQSMMSHNAKTPSDRAAEIFHRVDWDSFGMG-AQFSEESSP---------SSKPIGQSDDRIVRSPKRRVSPEGGVSLKIKKLMDSTEMMGFAARGLLMNEYKSRVESANVG-RPLKAWREYF-MNRG 407          

Query:   16 VERGDLWKSKALSVQLRLRQRFRVEVDRRLRHHPIFSNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAXVTQPQNLPXXDT--DRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAAPPYTEEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEANRG 1434
            V++ DLWKS AL   L+LR RFR+ VD       +FS DG FSST  RW+ RFR+FRR+SLPS   FY +RV K+  AEEES + RMLQ VAVP+IGN CHVFMNG N+VQVYG+EKLHDA+L RPK KPL+TVSNHVAS+DDP V+++LLP   LLD +NLRWTLCA+DRCF NPVTSAF RSVKVLP+SRG+GIYQ+                    GMD+AISKLN GGWVHIFPEG RSRDGGKT+GS KRG+GRL+LDAD +PMVVPFVH+GMQDIMP+GAS+PRIG TVTV+IGDPI+F+D+L++EGA+HVSR  LYDAVSSRIG RL +LK QVD++    Q        T  DRA  I  +VDW+SFGMG   +SE+            ++ P  +       S +   S EGG++  ++  MD +E MGFAARG+ MN        +  G  PLKAWR Y   NRG
Sbjct:    6 VDKADLWKS-ALLFNLKLRDRFRIAVDDHRGRATVFSPDGCFSSTIHRWVTRFRNFRRESLPSPPAFYRRRVSKDLTAEEESALFRMLQTVAVPLIGNACHVFMNGFNRVQVYGLEKLHDALLNRPKNKPLVTVSNHVASVDDPFVIASLLPPKFLLDARNLRWTLCATDRCFKNPVTSAFSRSVKVLPISRGEGIYQQ--------------------GMDIAISKLNNGGWVHIFPEGSRSRDGGKTMGSAKRGIGRLILDADTLPMVVPFVHTGMQDIMPVGASVPRIGKTVTVIIGDPIHFNDILSTEGAQHVSRKHLYDAVSSRIGQRLYDLKAQVDRVYIEQQSMMSHNAKTPSDRAAEIFHRVDWDSFGMG-AQFSEESSP---------SSKPIGQSDDRIVRSPKRRVSPEGGVSLKIKKLMDSTEMMGFAARGLLMNEYKSRVESANVG-RPLKAWREYF-MNRG 447          

Query:  274 MLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAXVTQPQNLPXXDT--DRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAAPPYTEEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEANRG 1434
            MLQ VAVP+IGN CHVFMNG N+VQVYG+EKLHDA+L RPK KPL+TVSNHVAS+DDP V+++LLP   LLD +NLRWTLCA+DRCF NPVTSAF RSVKVLP+SRG+GIYQ+                    GMD+AISKLN GGWVHIFPEG RSRDGGKT+GS KRG+GRL+LDAD +PMVVPFVH+GMQDIMP+GAS+PRIG TVTV+IGDPI+F+D+L++EGA+HVSR  LYDAVSSRIG RL +LK QVD++    Q        T  DRA  I  +VDW+SFGMG   +SE+            ++ P  +       S +   S EGG++  ++  MD +E MGFAARG+ MN        +  G  PLKAWR Y   NRG
Sbjct:    1 MLQTVAVPLIGNACHVFMNGFNRVQVYGLEKLHDALLNRPKNKPLVTVSNHVASVDDPFVIASLLPPKFLLDARNLRWTLCATDRCFKNPVTSAFSRSVKVLPISRGEGIYQQ--------------------GMDIAISKLNNGGWVHIFPEGSRSRDGGKTMGSAKRGIGRLILDADTLPMVVPFVHTGMQDIMPVGASVPRIGKTVTVIIGDPIHFNDILSTEGAQHVSRKHLYDAVSSRIGQRLYDLKAQVDRVYIEQQSMMSHNAKTPSDRAAEIFHRVDWDSFGMG-AQFSEESSP---------SSKPIGQSDDRIVRSPKRRVSPEGGVSLKIKKLMDSTEMMGFAARGLLMNEYKSRVESANVG-RPLKAWREYF-MNRG 357          

Query:  328 NGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGAS------IPRIGNTVTVVIGDPIYFD 933
            N  N+  V+  + L + V  RP G PLITVSNH++++DDP++        + LD +  RW L A D CF NP+ S  FR+ K +P++RG GIYQ+                     M+ A+ +L  G W+H FPEG   +D    I   K G   L+  +   P+V+P +H G +++MP   +      +P     + VV+G+PI FD
Sbjct:   35 NLCNKSSVHNADTLMNLVQSRPPGVPLITVSNHMSTLDDPVMWGAFKGL-LSLDPELARWVLAAEDICFRNPIFSYIFRTGKCIPITRGGGIYQE--------------------NMNEALQRLKDGSWLHTFPEGKVFQD-DVPIRRLKWGTASLIARSPVTPIVLPIIHRGFEEMMPENYNNGRRPLVPLPNKHLKVVVGEPIEFD 220          

Query: 1405 WRRYLEANRGEKQKMA--GFCEMPEAMVL------QILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVL----------NDADNGSKKILL-----------SLIDLCNXNNSDVYYLQDLNLNVPISL-GLRHEYLDIAGHCHGIICLTDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHFEGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQMYFKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVPESLQDTKECYGSLAVWNGSIALFSVHVESGVRKSIGIWEMNDLD--GSWTKHLTIVPIAGFGMPLTFWNSDELVMVAADGRVVSHNFVTKMLKELPVSGVFL-ERFQAFVYVYSLVS 2604
            W   +EA + E+++    G    PE++VL      +IL  LP KS+ RFRCV K +    ++P F  +HL   + N    S   L ++ ++          N   +G + +             S+      N    +   D  + + ++    R  +++I G  +G++C++     VFL NP   +SK LP++      PK +   +      GFG+D    DYK+V++V   E          A VY++ ++SWR I      ++ +  +   Y  G ++  AI         N++V+++F++  E F ++PVP+  +D    + +  V  GS+      V S       IW M++     SW++ + I  +     PL    +DE V++  DG +V +NF T     L + GV L + F+A  YV SL+S
Sbjct:    8 WEAIMEATKRERRREDDDGEKASPESLVLPPEIITEILLRLPAKSIGRFRCVSKLFCTLSSDPGFAKIHLDLILRNESVRS---LHRKLIVSSHNLYSLDFNSIGDGIRDLAAVEHNYPLKDDPSIFSEMIRNYVGDHLYDDRRVMLKLNAKSYRRNWVEIVGSSNGLVCISPGEGAVFLYNPTTGDSKRLPENF----RPKSVEYERDNFQTYGFGFDGLTDDYKLVKLVATSEDIL------DASVYSLKADSWRRI-----CNLNYEHNDGSYTSGVHFNGAIHWVFTESRHNQRVVVAFDIQTEEFREMPVPDEAEDCSHRFSNFVV--GSLNGRLCVVNSCYDVHDDIWVMSEYGEAKSWSR-IRINLLYRSMKPLCSTKNDEEVLLELDGDLVLYNFETNASSNLGICGVKLSDGFEANTYVESLIS 419          

Query: 1465 MPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVH-----LSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYYLQDLNLNVPISLGLRHEYLDIAGHCHGIICL-TDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHFEGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQ--MYFKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVP---------ESLQDTKECYGSLAVWNGSIALFSVHVESGVRKSIGIWEMNDLDG--SWTKHLTIVPIAGFGMPLTFWNSDELVMV 2484
            +P  M+ +IL  LP KSL RF+CV  SW   I+   F   H      SK+  ++      I   RY L                + +  N+   Y+ + +  +     L  +Y  + G CHG++C   DY + ++L NP +K  + L  S L     + +       +  GFGYD    DYKVV ++       I       ++Y+     WR      PS VV    S+  +Y  G   W A      T   +   I+S++M  + F ++P P          +L D + C   +    G+ A               +W M +     SW+K L+I  +  F  PL  W SD LV++
Sbjct:   14 LPLEMMEEILLRLPVKSLTRFKCVCSSWRSLISETLFALKHALILETSKATTSTKSPYGVITTSRYHLKSC------------CIHSLYNASTVYVSEHDGEL-----LGRDYYQVVGTCHGLVCFHVDYDKSLYLWNPTIKLQQRLSSSDLETSDDECV-------VTYGFGYDESEDDYKVVALLQQRHQVKI-----ETKIYSTRQKLWRS-NTSFPSGVVVADKSRSGIYINGTLNWAA------TSSSSSWTIISYDMSRDEFKELPGPVCCGRGCFTMTLGDLRGCLSMVCYCKGANA--------------DVWVMKEFGEVYSWSKLLSIPGLTDFVRPL--WISDGLVVL 320          

Query: 1477 MVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNS---FQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYYLQDLNLNVPISLGLRHEYLDIAGHCHGIICLTDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVM---HFEGFWILFHPHXAEVYTMSSNS-----WREIKVDIPSSVVWCPSSQMYFKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVPESLQDTKECYGSLAVWNGSIALFSVHVESGVRKSI-GIWEMNDLDGSWTKHLTIVP 2427
            M ++IL+ LP K LMR  CV K W   I    F   +L +S+      F +S    F R     +      +LLS              L D ++  P+          ++    G++C   Y+  + +CNP LK+ + LP          +I + +   +   FGYD   K +KV+ + +    F   W    P   +VYT+ S+      WR I  +   SVV      ++  GF Y+ A          NK +++ FN+  E F+ I +PE +    + +  L  + G +AL +          +  IW  N++D  W K +  +P
Sbjct:   13 MQIEILARLPLKYLMRCMCVSKKWASLIRGEDFRSAYLLRSMARPRLLFVASRSRKFTRETCFHSVYQEPPLLLS---------GKRQMLTDNHI-APV--------FTVSNPILGLLCHQGYNNEIVICNPGLKKFRNLP----------QIQVPEGASVRSFFGYDKVDKVFKVLCVCVPQTQFGAGWTSKEPKKYQVYTVRSDHEKPSFWRPIICNDDHSVV--TDEGLFNGGFLYYGA------RSSCNKPMVMRFNVSSEAFAVIKLPEEVD--IDYHWRLVNYKGKVALVNTFDSKFKFNGVFEIWVRNEVDRKWDKDIIKIP 303          

Query: 1465 MPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSD----VYYLQDLNLNVPISLGLRHEYLDIAGHCHGIICLTDYSEXVFLCNPALKESKLL-PKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHFEGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQMYFKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVPESLQD 2277
            +PE +VL+ILS +P  SL RFR   + W   + + SF   H +            I F+ Y+++             IDL   NN++           +L  P+S       +  A HC G++        + + NP   E+K + P++       KE ++          GYD ++  YK++R  MH  G    FH   +EVY  +S+SWR + V     +    S  M  KG  YWFA+  D  + D+ ++ +LSF+   E F  +P+P  +++
Sbjct:    3 LPEDLVLEILSKVPAVSLARFRSTCRRWNALVVDGSFAKKHYAYGPRQYPIVIMLIEFRVYLVS-------------IDLHGINNNNGAPSAKLTGQFSLKDPLSNSSEEVDIRNAFHCDGLLLCCTKDRRLVVWNPCSGETKWIQPRNSY-----KESDLY-------ALGYDNRSSSYKILR--MHPVGN--PFHIE-SEVYDFASHSWRSVGVTTDFHIQTNESYGMNVKGTTYWFALSKDWWSSDD-RRFLLSFDFSRERFQCLPLPADVKN 247          

Query: 1420 EANRGEKQKMAGFCEMPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYYLQDLNLNVPISLGLRHEYLDIAGHCHGIICL-TDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTG--IAVGFGYDXKAKDYKVVRIVMHFEGFWI----LFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQMYFKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVPESLQDTKECYGSLAVWNGSIALFSVHVESGVRKSIGIWEMNDLDGSWTKHLTIVPIA----------GFGMP-LTFWNSDEL------VMVAADGRVV-SHNFVTKMLKELPV 2547
            +  R  K+ M     +P+ +V +I   LP K+LMRF+ + K W   + +  F   HL K  + S      ++    ++ +  N   +I    I L       V +L     N P      H  +  +  C GI C+ +  ++ +++ NPA +  + LP +  ++   K    L +    I V      KA DYK+V         W+           EV+   +N+WR +   IPS  ++         G  YWF      +T +   KVI + ++  E+F  +P P  +  ++  +  + + + S+ ++    +  + +   IW +   + +W K  TI  ++          G+ +  L +W   +L      V +  D +++ SH +   + K L V
Sbjct:   18 QRKRRYKKLMIASSSLPDDVVEEIFLKLPVKALMRFKSLSKQWRSTLESCYFSQRHL-KIAERSHVDHPKVM----IITEKWNPDIEISFRTISL-----ESVSFLSSALFNFPRGF---HHPIYASESCDGIFCIHSPKTQDIYVVNPATRWFRQLPPARFQIFMHKLNPTLDTLRDMIPVNHLAFVKATDYKLV---------WLYNSDASRVTKCEVFDFKANAWRYLTC-IPSYRIYHDQKPASANGTLYWFT-----ETYNAEIKVI-ALDIHTEIFRLLPKPSLIASSEPSHIDMCIIDNSLCMYETEGDKKIIQE--IWRLKSSEDAWEKIYTINLLSSSYCHFHVLDGYNLTRLCYWTQKDLVESSTPVAIYKDKKIILSHRYTCNLGKRLEV 387          

Query: 1435 EKQKMAGFCEMPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDV-YYLQDLNLNVPISLGLRHEYLDIAGHCHGIICLTDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQS-TGIAVGFGYDXKAKDYKVVRIVMHFEGFW-------ILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQ-MYFKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVP 2262
            +K+ +    E+PE M++ IL  LP KSLMRF+CV K W   I +  F +     S      S +C+      L D +N SK +LL        ++SD    + D +  +PI  G       +     G++C       V +CNP+ ++   LP             I++S T +   FG+D    +YKV+ +      FW       ++   H   V  + + SWR  K        + P S+ M   G  Y+ A        D N+ V++SF++  E F+ I +P
Sbjct:   17 QKKTVVFLPEIPEEMLIDILIRLPAKSLMRFKCVSKLWLSLITSRYFTNRFFKPS------SPSCLF---AYLVDRENQSKYLLLQSSSSSRHDHSDTSVSVIDQHSTIPIMGGY------LVNAARGLLCYRT-GRRVKVCNPSTRQIVELP-------------IMRSKTNVWNWFGHDPFHDEYKVLSL------FWEVTKEQTVVRSEHQVLVLGVGA-SWRNTKSHHTPHRPFHPYSRGMTIDGVLYYSA------RTDANRCVLMSFDLSSEEFNLIELP 260          

Query: 1465 MPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNN-SDVYYLQDLNLNVPISLGLRHEYLDIAGHCHGIICLTDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIV---MHFEGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQMYFKGFYYWFAIXLDKQTLDENK--------------KVILSFNMDDELFSDIPVPESLQD-TKECYGSLAVWNGSIALFSVHVESGVRKSIGIWEMNDLD--GSWTKHLTI 2421
            +P  +V  I   LP K+L+R R + K  Y  IN+P F++ HL + +         ++  R  L           L  +DL + ++ SDV +        P+  G   E   + G  +G+I L++    + + NP+ ++   LP S + LP            +  G GYD  + DYKVVR+V   +  E       P+  +V+++  NSW+ I+  + SS+      Q+ F  FYY          L  N                +I+ F++  E F  +  PE++ +   +    + V +G + L   + +S     + +W M + +   SWTK  T+
Sbjct:    4 IPMDIVNDIFLRLPAKTLVRCRALSKPCYHLINDPDFIESHLHRVLQTG---DHLMILLRGALR----------LYSVDLDSLDSVSDVEH--------PMKRGGPTE---VFGSSNGLIGLSNSPTDLAVFNPSTRQIHRLPPSSIDLPDGSSTRGY----VFYGLGYDSVSDDYKVVRMVQFKIDSEDELGCSFPYEVKVFSLKKNSWKRIE-SVASSI------QLLFY-FYYHLLYRRGYGVLAGNSLHWVLPRRPGLIAFNLIVRFDLALEEFEIVRFPEAVANGNVDIQMDIGVLDGCLCLMCNYDQS----YVDVWMMKEYNVRDSWTKVFTV 303          

Query:    1 MAAARVE--RGDLWKSKALSVQLRLRQRFRVEVDRRLRHHPIFS--NDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLA--XVTQPQNLPXXDTDRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAAPPYTEEPQSADWSYRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEAN 1428
            MA  R+E  RGDLWKSKA ++QLRLR RFRV VDR  R   IFS  +DGYFSST QRWL  FRDFRRDSL S + FY KRV K+FNA+EES+I+RM+Q+VAVP++GN+CHVFM+GLN+VQVYGVEKLHDA+L RPK KPL+TVSNHVAS+DDP ++++LLP  VL+D QNLRWTLCASDRCF NPV+SAFF+SVKVLPV+RG+GIYQK                    GMD+AI+KLN G WVHIFPEG RSRDGGKT+GS KRGVGRL+LDAD +P+V+PFVH+GMQ+IMPIGA++PRIG  VTV++GDPI+FDD+L++EG +++SRGK+YDAVSSRIG RL++LKVQV+KLA     + Q      T+RA  +LQQVDW SFG G+   +E+     +        P  ++E  S+   +R+GFS +  I S MR +MD +E +GFAARG+FMN RA E + S R V P++AW+++LEAN
Sbjct:    1 MAVQRIELGRGDLWKSKAKALQLRLRDRFRVVVDRHRRRPHIFSAASDGYFSSTVQRWLNHFRDFRRDSLHSHSAFYRKRVSKDFNADEESVIIRMVQSVAVPLLGNMCHVFMHGLNRVQVYGVEKLHDALLHRPKNKPLLTVSNHVASVDDPFIIASLLPPSVLMDAQNLRWTLCASDRCFKNPVSSAFFQSVKVLPVARGEGIYQK--------------------GMDMAIAKLNSGSWVHIFPEGSRSRDGGKTMGSSKRGVGRLILDADTVPLVIPFVHTGMQEIMPIGATLPRIGKRVTVLLGDPIHFDDILDAEGVENISRGKMYDAVSSRIGQRLQQLKVQVEKLALEQSVEFQQAAAGITERAADMLQQVDWGSFGAGSHVSTEERDLPCE--------PRPSQELLSSGRYFRIGFSYDSIIISRMRGYMDSTELLGFAARGLFMNFRAREHTASIRDVGPVRAWKQFLEAN 454          

Query: 1465 MPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYYLQDLNLNVPISLGLRHEYLDIAGHCHGIICLTDYS--EXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHFEGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQMY--FKGFYYWFAIXLD-KQTLDENKKVILSFNMDDELFSDIPVPESLQDTKECYGSLAVWNGSIALFSVHVESGVRKSIGIWEMNDLDGSWTKHLTI-VPIAGFGMPLTFWNSDELVMVAADGRVVSH 2511
            +PE ++ +ILSWLP K+L++F+CV KSWY  I + +F+  HL+   DN +  S   L + +V       +K   L+L +      S +   ++L  + PI          I G C+GI  L  YS  +   L NPA  E K LP   +R P    ++         GFG+D   KDYKV+ I    +    + +P    VY++S++SWR    D+P +     +++ Y    G +YW        +T DE    I+SF+M  +L  D+ +P   +  +E    L+V++ S+AL +VH    ++  + IW +   +G WTK  TI     G   P+  W +   + +     ++S+
Sbjct:   13 LPEDLITEILSWLPVKALLQFKCVCKSWYAIITSQTFISRHLNNYYDN-YDDSDTFLAQYFV-------TKLGELALYEFLVDETSTILSYEELR-DRPIYNSF------ICGPCNGIFYLDRYSYRDHRALWNPATNELKTLP-PLIRKPNLPSLSFYAGVKEVFGFGFDRVTKDYKVIVIKSWSKTNSKIRYPLSVFVYSLSTDSWR-YWGDLPQNYKLLSNNKCYICLNGVFYWLGSDYSGGKTYDE---AIISFDMATDLIQDMQLPNYDKPARETV--LSVYHDSLALLTVH---DIKHFLEIWTLK--EGCWTKQFTIGTSSYGRISPIAHWKNTTKLFLIIQRNILSN 340          

Query: 1465 MPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYYLQDLNLNVPISLGLRHEYLDIAGHCHGIICLTDYS--EXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHFEGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQMY--FKGFYYWFAIXLD-KQTLDENKKVILSFNMDDELFSDIPVPESLQDTKECYGSLAVWNGSIALFSVHVESGVRKSIGIWEMNDLDGSWTKHLTIVPIAGFG--MPLTFWNS 2466
            +PE ++ +ILSWLP K+L++F+CV KSWY  I + +F+  HL+   DN +      L + +V       +K   L+L +      S +   ++L  + PI          I G C+GI  L  YS  +   L NPA  E K LP   +R P    ++         GFG+D   KDYKV+ I    +    + +P    VY++S++SWR    D+P +     +++ Y    G +YW        +T DE    I+SF+M  +L  D+ +P+  +  +E    L+V++ S+AL +VH    ++  + IW +   +G WTK  T V  + +G   P+  W +
Sbjct:   13 LPEDLITEILSWLPVKALLQFKCVCKSWYAIITSQAFISKHLNNYYDN-YNDIDTFLAQYFV-------TKLGELALYEFLVDETSTILSYEELR-DRPIYNSF------ICGPCNGIFYLDRYSYRDHRALWNPATNELKTLP-PLIRKPNLPSLSFYAGVKEVFGFGFDRVTKDYKVIVIKSWSKTNSKIRYPLSVFVYSLSTDSWR-YWGDLPQNYKLLSNNKCYICLNGVFYWLGSDYSGGKTYDE---AIISFDMATDLIQDMQLPDYDKPARETV--LSVYHDSLALLTVH---DIKHFLEIWTLK--EGCWTKQFT-VGTSSYGRISPIAHWKN 325          

Query:  286 VAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIG------ASIPRIGNTVTVVIGDPIYFD----------------------DLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLA 1050
            + +  +G       N LN   V+  + L + V  RP G PLITVSNH++++DDP++         + D    RW L A D CF N + S FFR  K +P++RG GIYQK                     M+ A+ +L+ G W+H FPEG  S++    I   K G   L++ +   P+V+P VH G +++MP           P    ++ +VIG+P+ F+                       +L+  G    ++  LY ++S +I   +  L+    KL+
Sbjct:   21 MVIMAVGAFAKAVANLLNTTTVHNADTLINLVRSRPLGVPLITVSNHMSTLDDPVMWG--FKGFPIFDSNLARWALAAEDICFKNSLLSYFFRIGKCIPITRGGGIYQKH--------------------MNEALERLSDGEWLHTFPEGKVSQEDA-PIRRLKWGTASLIVRSPVTPIVLPIVHHGFEEVMPENFWFGRRPPFPLCNKSINIVIGEPMEFNLPKMTQMAISTSHNLHNPTRGWPILSPSGLDEAAQRCLYTSISDQIQTSMESLRSSSKKLS 280          

Query: 1459 CEMPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYYLQDLNLNVPISLGLRHEYLD------IAGHCHGIICL-TDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHFEGFWIL--FHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQMY----------FKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVPESLQDTKECYGS-LAVWNGSIALFSVHVESGVRKSIGIWEMNDLDGSWTKHLTIVPIAGFGMPLTFWNSDELVMVAADGRVVSHNFVTKMLKELPVSGVFLERFQAFVYVYSLVSVK 2610
            C +PE ++++ILS LP K+L++F+CV KSWY  I + +F+ +HL+   +N         F              +   L++L           QD +L       L H+ LD      + G C+GI  + ++ S    L NPA KE KLLP+   ++     + +      + GFG+D    DYKVV I   +   + L  F      VYT+ ++SWR           W    Q Y            G YYW A          +  VILSFNM  + F +I  P+     K  Y + L +++ SIA  +VH    V K + IW +N  +G W +     P+     P+  W +  +++ + + +++ ++   + LK+L   G  +  ++  VY  SLVS+K
Sbjct:    7 CLLPEDVIIEILSLLPVKTLLQFKCVCKSWYGIITSSNFISLHLNNHYNNIKSGHLLAHF--------------VCPQLLEL----------FQDESLT-----DLSHQGLDPPIRGRLCGPCNGIFYVDSEDSSGSGLWNPATKEFKLLPE---KIRNKSSLPLYYED--SYGFGFDPVTNDYKVVVIRESYTREYYLEKFPSSLVIVYTLRTDSWR----------CWGSLDQGYTLLGNYCYTNVDGVYYWQA------GHGVHMNVILSFNMATDAFQEIQEPDY---DKPAYSTRLILYHDSIAFSTVH---NVEKFLDIWVLN--EGCWIRQFKSRPLLELRNPVAHWKNGNVILDSDNDQLMLYDTNKQELKDLRFKGTGV-CYEILVYRESLVSIK 351          

Query: 1465 MPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYYLQDLNLNVPISLGLRHEYLDIAGHCHGIICL-TDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHF----EGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQMYF----------KGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVPESLQDTKECYGSLAVWNGSIALFSVHVESGVRKSIGIWEMNDLDGSWTKHLTIVPIAGFGMPLTFWNSDELVMVAADGRVVSHNFVTKMLKELPVSGVFLERF----QAFVYVYSLVSV 2607
            +PE +V++ILS LP K+L++F+CV KSWY  I +P+F+  HL      S   S C+L +  V    +  S ++LL            V     L  N+P           + G C GI  +  DY +     NPA+ E K LP     LP P           A GFG     KDY+VV +  ++    E      +P    VY+ S+ SWR           W   S+ Y+           G ++W       +   + +KVI+SF+M  E   +I +P+    +  C   LA +  S+A+  VH      K + +W +N  +  W K  +I P+     P+  W + +L++V+  G ++  +  T+      +SG+ L R+      F Y  SLV V
Sbjct:   42 LPEDVVIEILSRLPVKNLLQFKCVCKSWYAIITSPNFISKHLRNYYSKS-DDSDCLLVQYCVTQAGELESLELLLD-------ETPKVLSYASLG-NMPFHSPF------LCGPCDGIFYMYRDYYDFRAFWNPAVNEFKFLPP----LPNPPSNFSYSPQYDAYGFGLHPVTKDYEVVVMKDYWREKQEERGGCRYPLRVFVYSSSTGSWRH----------WGDLSRYYYLQNNKCYICMNGVFFWLG---SYEIFGDPEKVIISFDMATETCQEIQLPD-CGKSHNCQ-CLATYQDSLAILDVH-----EKFLHMWTLN--ERCWVKCFSIGPLPEISYPIGHWKNSKLILVSDSGELILCDPSTQ-----EISGLGLTRWVRCVGVFAYKESLVLV 395          

Query: 1465 MPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYYL----QDLNLNVPISLGLR--HEYLDIAGHCHGIICLTDYSEXV----FLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHFEGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPS-SQMYFKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVPESLQDTKECYGSLAVW-NGSIALFSVHVESGVRKSIGIWEMNDLDGSWTKHLTIVPIAGFGMPLTFW-NSDELVMVAADGRVVSHNFVTKMLKELPVSGVFLERFQAFV--YVYSLV 2601
            + E ++ +IL  LP KSL+R   + KSW   I +P+F+  HL  +I ++               D  N      L L+ LC+    + Y L    QD N ++ +    +    Y  + G  +G+ICL +    +     L NP +++  ++           +  IL      VGFGYD +A DYK++R+V   +  +   +     +Y+++  SWR I+   P         S  +  G  +W A   D+     N  V+L F+M DE+F +I +P  L + +    SL V+   SI++      S V+  I + +   +  SWTK +  +   G G+P       +EL+M    G +VS +  ++++++L + G   E  + F+  Y+ SLV
Sbjct:    5 LSEDLIQEILYKLPIKSLLRCTSLCKSWNSLIKSPTFIFKHLQHTISST---------------DRQN------LFLLRLCSREREEQYSLRLDNQDFNEHMQLHFPFKSSESYFHVIGSSNGLICLANIFRSLIVSFILWNPLIQKYMIV-----------KPRILGPVYSFVGFGYDSRANDYKLIRMVSFQKSKFRSENFPEIALYSLNEGSWRGIRQTGPLRYDTDQRVSSAFLNGVVHWIAYRADQHEGVSN--VVLGFDMSDEIFLEIALPSCLANVRPSCMSLMVYKESSISVCQASFLSSVQFHIWVMKEYGVVESWTKLVLTLAAQGEGVPRALGIRKEELLMEKKRGWIVSGDLESQLVRDLRIWG---EPSRTFIGSYLESLV 361          

Query: 1465 MPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYYLQDLNLNVPISLGLRHEYLDIAGHCHGIICL-TDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHF---EGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQMY----------FKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVPESLQDTKECYGSLAVWNGSIALFSVHVESGVRKSIGIWEMNDLDGSWTKHLTIVPIAGFGMPLTFWNSDELVMVAADGRVVSHNFVTKMLKELPVSGVFLERFQAFVYVYSLVSVK 2610
            +PE ++++ILS LP K+L++F+CV KSW+  I +P  +  HL    D +   S C+L +  V    +  S ++L+           D    + L+  +   +  +  Y  I G C GI  L   + +   L NPA+ E K LP     +P P           A GF      KD +V+ +  ++   EG W   +P    VYT+SS+SWR           W   S+ Y           +G +YW    L       + +V+++F+M   +  +I +P+   D      SLAV+N SIAL  V         + +W ++  +  WTK   + P+ G   P+  W ++ +++++    ++  +  T+ +  L   G  +     F Y  SLV VK
Sbjct:   45 LPEDVIIEILSRLPVKNLLQFKCVCKSWHAIITSPKLISKHLRNYYDKN--DSDCLLAQYRVTQAGEIASFELLV-----------DETPTRALSYGLLDRMPFQSPY--IYGPCDGIFYLYGHFYDFHALWNPAINELKTLPP----IPNPPFSFSYSPLWNAYGFRLHPVTKDCEVIVMREYWREEEGAWEDRYPLSVFVYTLSSDSWR----------YWGDLSRYYHLRNNKCYICVEGVFYW----LGSYGACGDPEVVINFDMATNVCQEIQLPD--YDKSINSESLAVYNDSIALLVVQ-----ESVLHVWTLD--ERCWTKKFVVGPLLGVQYPVGHWQNNTIILISDSYELLLCDPRTQEMSGLGFEGGTIRCEGIFAYKESLVPVK 398          

Query: 1489 ILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYYLQDLNLNVPISLGLRHEYLDIAGHCHGIICLTDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHF-----EGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQ----------MYFKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVPESLQDTKECYGSLAVWNGSIALFSVHVESGVRKSIGIWEMND--LDGSWTKHLTIV---PIAGFGM---PLTFWNSDELVMVAADGR 2499
            ILS LP KSL RFRCV KSW K I++P F++ HL +S     Q+ T +     +L DA N      L  +DL + + + +    +L  N   S     E   + G C+G++ L +    + L NP+ +E K++P S L LP   + + + S     GFG+D   +DYKVVR + HF     +GF   FH    +VY++ SNSW+ I  D P  + +               ++     +W A  + K   +    +I++F++  E F  IP P+   +  E   ++ V  G + +F     +   K + IW M +  +  SWT   T++    +  F +   PL +    + +++  D R
Sbjct:   11 ILSRLPVKSLKRFRCVSKSWCKEIDSPYFINTHLKRSS----QAHTHL---NLILRDATN------LCTVDLDSPDFTSI----ELKNNPLKSDDCATE---VMGSCNGLLALLNSDFSIALYNPSTREKKMIPVSPLELPNDLDDSKVSSLFNFYGFGHDPINEDYKVVRFI-HFYGDSPDGF---FHCE-VKVYSLKSNSWKRID-DYPYDLRFILPPDYHPRCRRGYGVFANSAVHWKATVVGKGK-ENGSDLIVAFDLGAEEFKIIPQPDYSSNEHEM--NVGVLGGCLCVFC----NKNCKQVEIWVMKEYGVKESWTHLCTVIAQLQVKAFWLHARPLAYSKGGDKILLELDNR 337          

Query: 1489 ILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYYLQDLNLNVPISLGLRHEYLDIAGHCHGIICLTDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHF-----EGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQ----------MYFKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVPESLQDTKECYGSLAVWNGSIALFSVHVESGVRKSIGIWEMND--LDGSWTKHLTIV---PIAGFGM---PLTFWNSDELVMVAADGR 2499
            ILS LP KSL RFRCV KSW K I++P F++ HL +S     Q+ T +     +L DA N      L  +DL + + + +    +L  N   S     E   + G C+G++ L +    + L NP+ +E K++P S L LP   + + + S     GFG+D   +DYKVVR + HF     +GF   FH    +VY++ SNSW+ I  D P  + +               ++     +W A  + K   +    +I++F++  E F  IP P+   +  E   ++ V  G + +F     +   K + IW M +  +  SWT   T++    +  F +   PL +    + +++  D R
Sbjct:   11 ILSRLPVKSLKRFRCVSKSWCKEIDSPYFINTHLKRSS----QAHTHL---NLILRDATN------LCTVDLDSPDFTSI----ELKNNPLKSDDCATE---VMGSCNGLLALLNSDFSIALYNPSTREKKMIPVSPLELPNDLDDSKVSSLFNFYGFGHDPINEDYKVVRFI-HFYGDSPDGF---FHCE-VKVYSLKSNSWKRID-DYPYDLRFILPPDYHPRCRRGYGVFANSAVHWKATVVGKGK-ENGSDLIVAFDLGAEEFKIIPQPDYSSNEHEM--NVGVLGGCLCVFC----NKNCKQVEIWVMKEYGVKESWTHLCTVIAQLQVKAFWLHARPLAYSKGGDKILLELDNR 337          

Query:    1 MAAARVERGDLWKSKALSVQLRLRQRFRVEVDRRLRHHPIFSNDGYFSSTFQRWLQRFRDFRRDSLPSSTTFYLKRVGKEFNAEEESIILRMLQAVAVPVIGNVCHVFMNGLNQVQVYGVEKLHDAVLRRPKGKPLITVSNHVASMDDPLVLSTLLPRHVLLDVQNLRWTLCASDRCFSNPVTSAFFRSVKVLPVSRGDGIYQKFVRSAVVTHIIANKTKRLQHGMDLAISKLNQGGWVHIFPEGXRSRDGGKTIGSXKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGNTVTVVIGDPIYFDDLLNSEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAXVTQPQNLPXXDTDRATVILQQVDWESFGMGNLTYSEDDGSAVQETEIQLAAPPYTEEPQSADWS--YRVGFSREGGIASXMRCFMDQSEFMGFAARGIFMNRRAEEPSPSGRGVAPLKAWRRYLEAN 1428
            MAAARVERGDLWK+KALSVQLRLR+RFRVEVDRRL+ HPIF++DGYFSSTFQRWLQRFRDFRRDSLPSST FY KRVGKEFNAEEES++LRMLQAVAVPVIGNVCHVFMNGLN +QVYGVEKLHDAVL RPKG+PLITVSNHVASMDDPLVL+ LLPRHVLLD QNLRWTLCA+DRCF+NP TSAFFRSV+VLPVSRGDGIYQK                    GMD AISKLNQGGWVHIFPEG RSRDGGKT+GS KRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIG TVTVVIGDPIYFDDLLN EGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLA VT+PQNLP  +T+RA VILQQVDWESFGMGNL  SEDDGS V ET++QL +  +T+EP+S D    +RVGFSREGGIAS MR FMD  + MGFAARG+FMNRR  E +PSGRGV PLKAW++YLEAN
Sbjct:    1 MAAARVERGDLWKNKALSVQLRLRERFRVEVDRRLKLHPIFTDDGYFSSTFQRWLQRFRDFRRDSLPSSTVFYRKRVGKEFNAEEESVLLRMLQAVAVPVIGNVCHVFMNGLNHIQVYGVEKLHDAVLHRPKGQPLITVSNHVASMDDPLVLAALLPRHVLLDAQNLRWTLCATDRCFANPATSAFFRSVRVLPVSRGDGIYQK--------------------GMDTAISKLNQGGWVHIFPEGSRSRDGGKTMGSSKRGVGRLVLDADNIPMVVPFVHSGMQDIMPIGASIPRIGKTVTVVIGDPIYFDDLLNCEGAKHVSRGKLYDAVSSRIGHRLRELKVQVDKLAQVTRPQNLPAQNTERAAVILQQVDWESFGMGNLVSSEDDGSQVPETQVQLVS-THTQEPRSTDTDRRFRVGFSREGGIASRMRSFMDHPDLMGFAARGLFMNRRVHETTPSGRGVGPLKAWKQYLEAN 457          

Query: 1465 MPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQS--STCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYY----LQDLNLN--VPISLGLRHEYLDIAGHCHGIICLTDYSEXVFLCNPALKESKLLPKSCLRLP--PPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHFEGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSS-QMYFKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVPESLQDTKECYGSLAVWNGSIALFSVHVESGVRKSIGIWEMNDL---DGSWTKHLTIVPIAGFGMPLTFWNSDELVMVAADGRVVSHNFVTKMLKELPVSGVFLERFQAFVYVYSLVSV 2607
            MPE MV+QILS LPPKSLMRFRCV KSWY FIN+P+FVDVHLSKSIDN F S  STC+LFKR VLN   N +  ILLSL+DL N +N DV      ++DLNLN   P+S+GLRH+ LDIAGHCHGIICLTD+SE VFLCNPALK+ KLLPKSCLRLP  PP  +N LQSTG+AVGFGYD +A+ YKVVRIVMHFEGFWILF PH AEVYTMSSNSWREIK DIPS+VVW  SS Q+YFKG YYWFA+ LDK+TLDENKKV+LSF+MDDELF   PVP+SLQD++E YGSL VWN SIALFS HVESGV K I IW M+      G WTKHLTI PIAG GMPLTFWNSDEL++VA DG VVSHNF TK+L+ LP+ GV  E FQA +Y  SL+SV
Sbjct:    1 MPEEMVVQILSRLPPKSLMRFRCVHKSWYNFINDPNFVDVHLSKSIDNRFSSKTSTCVLFKRCVLN---NEANHILLSLVDLSN-DNDDVQIQSNSIRDLNLNNVPPLSVGLRHDCLDIAGHCHGIICLTDFSENVFLCNPALKQLKLLPKSCLRLPQPPPNTLNRLQSTGVAVGFGYDSRARVYKVVRIVMHFEGFWILFFPHMAEVYTMSSNSWREIKTDIPSTVVWSSSSSQIYFKGVYYWFALELDKETLDENKKVMLSFDMDDELFFHTPVPDSLQDSEENYGSLGVWNESIALFSYHVESGVSKFIDIWVMDGFCGTKGCWTKHLTIEPIAGIGMPLTFWNSDELLLVATDGYVVSHNFDTKVLRNLPIHGVLFEHFQAVLYTSSLISV 391          

Query: 1447 MAGFCEMPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDAD-NGSKKILLSLIDLCNXNNSDVYYLQDLNLNVPISLGLRHE-------------YLDIAGHCHGIICLTDY-SEXVFLCNPALKESKLLPKSCLRLPP--PKEI--------------NILQSTGIAVGFGYDXKAKDYKVVRIVMHFEGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQMYFKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVPESLQDTKECYGSLAVWNGSIALFSVHVESGVRKSIGIW----EMNDLDGSWTKHLTIVPIA-GFGMPLTFWNSDELVMVAADGRVVSHNFVTKMLKELPVSGV-FLERFQAFVYVYSLVSVK 2610
            MA   +  E M+  ILS LPPKSLMRFRCV KSW+  I+ PSFVD HLS S+DN   SSTC+L K  VL D      +K + + +   + N  D+  L  LNL   +  GL  E              L+I+G C G+ICL  + SE + LCNPAL+E ++LPKSC+ LPP  P+++              + ++S    VGFGYD  +KDYKVVR      G +   HP   EVY++++++WREI VDI       PS QMYF GF+YW A         E + VILSF+M +E+F DI +PES  D  E Y S+AVW  S+ L +  VE+   K++ +W    E+    G WTKHL I P+A G   PL FW  +EL+MV  +G VV+++  T+MLK +P  G+      QA  YV S+VS+K
Sbjct:    1 MATLSKFSEDMMGNILSRLPPKSLMRFRCVLKSWHDLIDKPSFVDQHLSTSMDNKVTSSTCVLLKHNVLTDPTIKDDEKAVRATLFNPDSNQRDI-LLSSLNLGSLVDDGLEIENHVVPPPMRGYALSLEISGSCDGLICLNTFNSEDIVLCNPALEEYRVLPKSCILLPPRVPRQVEENEDDDYYEEDDDDEIESNPKCVGFGYDPNSKDYKVVRAAQFVSGVFTQ-HPSKVEVYSLAADTWREIPVDIQPHGSLNPSYQMYFNGFFYWIAYW------TEERNVILSFDMSEEVFHDIALPESGPDAYE-YTSIAVWKDSLVLLTSPVENEAPKTLDLWVLDEELKGAKGLWTKHLAIGPLAKGVEAPLVFWKDEELLMVTTNGDVVNYSLDTQMLKHVPRHGLGEPTNIQAVPYVNSIVSIK 416          

Query: 1465 MPEAMVL-QILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDV-----YYLQDLNLNVP----ISLGLRHEYLDIAGHCHGIICLTDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHFEGFWI--LFHPHXAEVYTMSSNSWREIKVDI--PSSVVWCPSS-QMYFKGFYYWFAIXLDKQTLD----ENKKVILSFNMDDELFSDIPVPESLQDTKE-----------CYGSLAV--WNGSIALFSVHVESGVRKSIGIWEMND-LDGSWTKHLTIVPIAGFGMPLTFWNSDELVMVAADGRVVSHNFVTKMLKELPVSGVFLERFQAFVYVYSLVSV 2607
            M E M L +IL  LP KSL+RF+CVRKSWY  I++P+FV+ HLS S+      STC+LF R++ +DA+ G K++  S + L N  + D      + ++D+   +     I LG+  E L +AGHCHGI+CL++ +  + LCNP +K+ KLLPKSCL              G AVGFGYD K+KDYKV RI  +    +   L  P   E+YT+S++SWREIK +     +  +CP   QMYF+G  YW      KQ+++    E K ++  F   DE+F +I +P+S    ++            Y  L +  WNG IALF  +  S    S G+W ++D   GSWT+HLT  P+ G    L FW SDE++MV  DG +VS+N  T+ LK LP +      F+  VYV SLVS+
Sbjct:    1 MWEEMALHRILPRLPSKSLIRFKCVRKSWYNLIDSPTFVENHLSISMHKIH--STCVLFNRFIYSDANTGEKELAFSFLYLRNDYDDDAENNVNFVVEDIKFPLSSRQYIGLGVI-ESLCMAGHCHGIVCLSESNSNLVLCNPGIKKIKLLPKSCLP----------DWWGCAVGFGYDPKSKDYKVSRIASYQADIYGDGLIPPPRVEIYTVSTDSWREIKNNSLETEATFFCPDYFQMYFQGICYWVGFEQPKQSVEYEDEEQKPMVFLFYTGDEIFHNILLPDSFYTYEDGSSYAYEMSYIMYTDLRIILWNGVIALFGFNRFSAFPDSYGVWVLDDGAKGSWTQHLTFEPLVGIKRVLEFWKSDEILMVTEDGDIVSYNLATEKLKNLPRNS--SSDFETIVYVNSLVSI 399          

Query: 1465 MPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYYLQDL--NLNVPISLGLRH------EYLDIAGHCHGIICLTDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHFEGFW---ILFHPHXAEVYTMSSNSWREIK---VDIPSSVVWCPSSQMYFKGFYYW--------FAIXLDKQTLDENKKVILSFNMDDELFSDIPVPESLQDTKECYGSLAV--WNGSIALFSVHVESGVRKSIGIWEMNDLD---GSWTKHLTIVPIAGFGMPLTFWNSDELVMVAADGRVVSHNFVTKMLKELPVSGVFLERFQAFVYVYSLVSV 2607
            M E MVL ILS LP KSLMRF+CVRKSWY  IN+P FV+ HLS S+ N  +S++CIL  R++ +D   G K++  S +  CN  + D + +     ++  P S G +       E L + G C GI+CL D  + + LCNPA+KE KLLPKSCL           Q    AVGFGYD K+KDYK+ RI    E  +   ++F P   E+YT++++SWREIK   ++  ++  W    +MY+KG  YW        F    D+   ++ K +I  F+  DE+  +I +P+ L +       + +  WN S+ALF +       +  G+W ++D D   GSWT+H T   +      L FWN+DE+++V   G +VS+N  T   K L +    L R +  VYV +LV +
Sbjct:    1 MSEEMVLHILSRLPSKSLMRFKCVRKSWYTMINDPMFVERHLSNSMHNK-RSTSCILVNRFLHSDTSTGEKELGFSFLYFCNDYDDDEHKVNSFVEDIKFPFSSGGQRSGFEVIESLSMIGQCDGIVCLCDRRDNIVLCNPAIKELKLLPKSCLP----------QLIQCAVGFGYDPKSKDYKIHRISCDGEEIYDQRLVFFPPRVEIYTLTTDSWREIKNNYLETENTFFWPEYFEMYWKGICYWLGYEQPKEFESYFDRLEDEKKKTMIFLFDTGDEVSHNILLPDCLYEAAVYRFDMRILLWNESVALFGLDSFGTFVECYGLWVLDDFDGAKGSWTRHCTFESVIDIKRVLAFWNNDEILLVDGCGNIVSYNLGTNNHKNLLIYTENLCRVETIVYVNTLVPI 397          

Query: 1465 MPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDV-YYLQDLN---LNVPISLGLRH-------------EYLDIAGHCHGIICLTDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHFEGFW----ILFHPHXAEVYTMSSNSWREIK---VDIPSSVVWCPSS-QMYFKGFYYWFAIXLDKQTL-------DENKKVILSFNMDDELFSDIPVPESLQDTKECYGSLAVWNGS---IALFSVHVESGVRKSIGIWEMNDLDGSWTKHLTIVPIAG--FGMPLTFWNSDELVMVAADGRVVSHNFVTKMLKELPVSGVFLERFQAFVYVYSL 2598
            M E M +QIL+ LPPKSLMRF+CV KSW+  +NNP FV  HL   + N+  SSTCILFKR VL+  ++  ++++ + ++L N N S+  + L + N   L+ P S+GL+              E + I GHC G+ CL+ Y+  +   NPA+KE ++LP+SCL            +    +GFGYD K KDY ++ I+ + E       ++ HP  AE+YT+S+NSWREI+   ++  ++  W   +   YF G +YW      K+ +       +E K+VI+ F+  DE+F ++P+P+   +      SL VWN S   IALF  +      ++  +W M++ DG WTKHL++VP       +PL  W  +E+++V  DGR+ S+NF T+ LK  PV      RF     +YSL
Sbjct:    1 MTEEMEVQILARLPPKSLMRFKCVCKSWHALLNNPHFVAKHL--HLYNNQPSSTCILFKRSVLSRTEHNKEELVFTFLNLRNDNKSNADHNLINCNVEDLHFPRSMGLKSRGQFIELPGLELGESVHIVGHCDGLFCLSLYTGELVFYNPAIKEFRVLPQSCLE----------DAFSCTLGFGYDPKRKDYVLLSIMSYGEEILDDERLVIHPPQAEIYTLSTNSWREIETHYLETETTYFWGNETFSTYFNGVFYWLGYEEKKEFVSFYDRLEEEKKQVIILFDTFDEVFHNMPLPDCFYEFPTHEMSLTVWNESIDTIALFGFY--RCEFETFEVWVMDEFDG-WTKHLSVVPKVDQEVDIPLALWRRNEVLLVDRDGRIFSYNFHTENLKFFPVHENERNRFCRGEGLYSL 400          

Query: 1456 FCEMPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQ---SSTCILFKRYVLNDADNGSKKILLSLIDLC--NXNNSDVY--------YLQDLNLNVPISLGLRHEY----LDIAGHCHGIICLTDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXK-AKDYKVVRIVMH----FEGFWILFHPHXAEVYTM-SSNSWREIKVD--IPSSVVWCP--SSQMYFKGFYYWFAIXLDKQTL-------------DEN---------------------------KKVILSFNMDDELFSDIPVPESL-QDTKECYGSLAVWNGSIALFSVHVESGVRKSIGIWEMNDL--DGSWTKHLTIVPIAGFGMPLTFWNSDELVMVAADGRV-VSHNFVTKMLKELPVSGVFLERFQAFVYVYSLVSVK 2610
            F ++ E +V  ILS LPPKSL+RF+C+RKSW   I  P FV++HLS       Q    ST ILFK ++L D +   K++L S+ +L   + +N D+           +DL ++    +    E+    +DI+ HC GI+CLTD+ + V LCNPA++E KLLP+S + L  P+E+ IL      VG G D K +K+YKVVR+V +     +    + HP  AEV+T+  S+SW+EI++   +  +  + P  +  +Y KG  YW A   D++ +             +EN                           K  ILSF+  +E+F  IP P  +     + +G   VW  S+A+F   + + +     IW M++    GSWTK+LT  P      PL  W S+E+VMVA D  V + +N  T+  K LP++GVF +R +A V   +LVS++
Sbjct:    6 FSKLSEELVTHILSRLPPKSLLRFKCIRKSWSVLITTPQFVEMHLSNFSSTRHQISTPSTTILFKHFILTDLNTDQKELLFSMFNLRTDDVDNDDMDGGDDHLRPVFEDLEVSCFRGVDTGGEFYRVGVDISSHCDGIVCLTDFHKKVALCNPAIREFKLLPESDVLLSSPEEVAIL-----GVGLGRDLKHSKNYKVVRLVTYGDKKVDDDRFVVHPPRAEVFTLQGSDSWKEIEIGNIVTKTGFFLPQHAVSVYCKGVVYWPATDKDREYVVSYNYTDDEYDYCEENEGEDEEDNPENNERRAREEEERKERDMKAGILSFDFGEEVFDIIPYPPDVGYYESKIFG---VWKESVAIF---IYASMPDCFDIWVMDESGEKGSWTKYLTFEPEKPL-FPLALWKSEEVVMVARDDVVLIFYNLETRKFKYLPLNGVFFDRTEAVVCASTLVSIQ 449          

Query: 1447 MAGFCEMPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSK-KILLSLIDLCNXNNSDVY-----YLQDLNLNVPISLGLRHEYLDIAGHCHGIICL-TDYSEXVFLCNPALKESKLLPK-------SCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHFEG------FWILFHPHXAEVYTM----SSNSWREIK---VDIPSSVVWCPSSQMYFKGFYYWFAIXLDKQTLDEN--------KKVILSFNMDDELFSD 2250
            MA  C++ E ++++IL+ LPPKSLMRF+C  K WY  INNP FV   LS    N   ++  I  KR V N   N S+ + + S++  C   +   +      ++D+N+ V +S+ +  E L I GHCHGIIC+  D    VFL NPA++E KLLP             P    +++    G A+GFGYD  +K YKVV I+ +         + ++ +P   +VYT+     S+SWR+IK   ++  ++ +W    ++Y KG  YW      K+ + E         ++V++SF+M DE+F +
Sbjct:    1 MAHSCKIGEDLLVKILTSLPPKSLMRFKCAAKWWYALINNPRFVGNQLS----NCLHNNQSIFLKRLVPNKDPNASETEYVFSVLTFCEDADGGAHRFLLSRVEDINVPVSMSVMIGGEELKIVGHCHGIICVHVDNYSKVFLWNPAIQEFKLLPSEKYLTDWESQVYPRAPYLSLGDRLGWAMGFGYDPISKAYKVVSIMFYGSQRHAHTLYSVVIYPLRVQVYTLGSSEESSSWRDIKTYSLETETTFLWPEGFEIYLKGMCYWLGTEQQKEFVHEEEIRYEERIRQVMVSFDMSDEVFDE 299          

Query: 1447 MAGFCEMPEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYYLQDLNLNVPISLGLRHEYLDIAGHCHGIIC--LTDYSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIVMHFEG------FWILFHPHXAEVYTM----SSNSWREIK---VDIPSSVVWCPSSQMYFKGFYYWFAIXLDKQTLD--------ENKKVILSFNMDDELFSDIPVPESLQDTKECYGS----LAVWN-GSIALFSVHVESGVRKSIGIWEMNDLDGS--WTKH----LTIVPIAGF---GMPLTFWNSDELVMVAADGRVVSHNFVTKMLKELPVSGVFLERFQ-AFVYVYSLVSV 2607
            MA  C++ E ++++ILS LPPKSLMRF+C  K W             L  + D +   +  +        D D G+   LLS +             +D+N+ V +S+    E L I GHCHGIIC  + +YS+  +  +    + +  P     LP    +        A+GFGYD  +K YKVV I+ +         + ++ +P   +VYT+     S+SWREIK   ++  ++ +W    Q++ KG  YW      K+ +D        + ++V++SF+M DE    + +P  L D    +      L VWN  SIAL   H    V    G+W M+D  G+  WTKH    L  +PI      G  L  W SDEL++V  DG  + +N  T+    LP   + +       VYV S+VS+
Sbjct:    1 MAHSCKIGEDLLVKILSSLPPKSLMRFKCAAK-W------------RLVPNKDPNASETESVFSVLTFCEDVDGGAHSFLLSRV-------------EDINVPVSMSVMSGGEELRIVGHCHGIICVHVDNYSKEKYFTDWESLDQQRAP----YLPLDYRLE------WAMGFGYDPISKAYKVVNIIFYGSQRHAHTLYSVVIYPLRVQVYTLGSSEESSSWREIKTYSLETETTFLWPERFQIHLKGMCYWLGSEQQKEFVDVEEMRYEEKIRQVMVSFDMSDE----VALPNELLDHDTTFFGLFVRLTVWNESSIALCVWHYSYDVSPYFGMWLMDDDFGACVWTKHAGFELASIPIMDLREGGWALALWKSDELLVVDKDGCTICYNLRTENRMSLPTIQICMSNLDPPIVYVNSIVSI 385          

Query: 1468 PEAMVLQILSWLPPKSLMRFRCVRKSWYKFINNPSFVDVHLSKSIDNSFQSSTCILFKRYVLNDADNGSKKILLSLIDLCNXNNSDVYYLQDLNLNVPISLGLRHEYLDIAGHCHGIICLTD------YSEXVFLCNPALKESKLLPKSCLRLPPPKEINILQSTGIAVGFGYDXKAKDYKVVRIV--MHFEGFWILFHPHXAEVYTMSSNSWREIKVDIPSSVVWCPSSQMYFKGFYYWFAIXLDKQTLDENKKVILSFNMDDELFSDIPVPE-SLQDTKECYGSLAVWNGSIALFSVHVESGVRKSIGIWEM--NDLDGSWTKHLTIVPIAGFGMPLTFWNSDELVMVAADGRVVSHNFVTKMLKELPVSGVFLERFQAFVYVYSLVSVK 2610
            PE +   ILS LP KSL+RF  VRK W   I +P F+  HL+ +I    QS       R ++    N ++K ++SL+     + +  Y L    L +P S+   H +L + G C+G++CL        +S  + L NPA++E  +LP S   +    + + +Q+ GIA GFGY     DYKVVRIV    F   WI      AEVY+   + W+E+             S     G  YW A          ++++I+SF+M D++F ++ +P+ S  DT  C   LA    S+ L  V+  SG ++ I +W+M  +D +  W +  TI P+ G   PL      E+ M +  G +V +N  ++  K +P+ G+     +   YV SLVS K
Sbjct:    4 PEHLTADILSRLPAKSLVRFSSVRKEWQALIRDPHFISQHLNLNIAKEDQSG------RLLVKYRCNVTRKNVISLL----LHGTHGYMLS--KLEIPSSVMDSH-HLKLVGSCNGLLCLAHDKSAHLWSPMILLWNPAIREFSVLPDSV--IDSVNDDDNVQARGIAHGFGYHPLIDDYKVVRIVSLSCFGNAWI-----RAEVYSSKMDCWQEVNT---FHFEIYEHSCTALNGLLYWIAYG------KGDRELIVSFDMCDDVFGELQLPDLSFLDTPMC-TKLAELKQSLYLI-VYTFSGRQREIYVWKMIEHDAEVFWKREWTIGPLLGIERPLGCGLYGEIYMESRKGDLVLYNPSSEEAKHIPICGLRCS-LEVHFYVESLVSTK 363