ppa002429m, ppa002429m (mRNA) Prunus persica

Query:  109 DCGPLRNLSYPF-TGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTS-TCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNS----TITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPI-MSTFKCEIGITVPILKTTAAKLVAN--RSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNR----VCDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTD 1983
            +CG   N+SYPF     + +YCG P F I C ++ P LTIS   Y + ++     +  ++ S ++   +C   + N ++    F Y+ S    + +FY C S    T+T P       C ++     S+       L+ +  ST  C+  + VP+      +   N     F E + EGF +++T    N C+ C    G CGF+++  E +C C +R     C   GL                               + K  P PL S++++             S PS  SK+ ++   +  GV +F+Y ELEEAT NF+ +KELGDGGFGTVY+GKL+DGRVVAVKRLYENN+KRVEQFMNEVEIL  L HRNLV LYGCTSR SRELLLVYEY+PNGTVADHLHG++ + G L+WP R+ IAIETA AL +LH +D+IHRDVKTNNIL+D++F VKVADFGLSRLFP DVTHVSTAPQGTPGYVDP+Y+QCYQLT KSDVYSFGVVLIELISS+ AVD  RHRH+INL+NMAINKIQNH ++ELVD  L F+++  +RRM  AVAELAF+CLQ E++MRP MDEVL+ L  I++E  G    +   ++I AD VGLL++  PP SPDS  T+
Sbjct:  355 NCGTGPNVSYPFWIPKEQESYCGFPNFSITCNDEKPVLTISDDYYVIREIFYTNHSFLMSNSAVYDGDSCPTPLHNFSLDRTPFNYSPSH-YDLLLFYNCTSVPVETLTIP-----IDCMSNATLH-SFASFHEEALEYMNFSTESCQSMVNVPV-DIDGEEGFGNLLNWNFTEILREGFVLSWTA---NNCSSCERSGGRCGFENN--EFICFCQDRPHLRTCHDEGLNYHRKVIIGVCAGLGTLLISSIFFLMYLRRYK-KRYPPPLFSRNIS-------------SDPS--SKTIFESQGSLHGVHIFTYEELEEATNNFDSSKELGDGGFGTVYHGKLRDGRVVAVKRLYENNYKRVEQFMNEVEILQLLRHRNLVSLYGCTSRHSRELLLVYEYVPNGTVADHLHGEQAKPGSLTWPTRMKIAIETASALKYLHASDIIHRDVKTNNILLDSNFSVKVADFGLSRLFPTDVTHVSTAPQGTPGYVDPDYHQCYQLTSKSDVYSFGVVLIELISSMPAVDITRHRHEINLSNMAINKIQNHALHELVDRSLGFDSDQNIRRMIMAVAELAFQCLQNEKEMRPAMDEVLEVLMGIESE--GCNIVKTEEVEIPADSVGLLKSKQPPASPDSVTTN 961          

Query:   76 NANLSNC-SRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDS-PELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTI-----TTPKLSNWFHC-----NNSLAFQDSYYLLGPVPLDPIMSTFK-CEIGITVPILKTTAAKLVANRS--------LFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNR 735
            N     C S +++CG ++ + YPF G  R  +CG   F + C ND  P + I SL +RVL +      +++AR D W  TC  +  ++T+    F Y    D  +++FYGC   +      T  +SN F C     N++ AF      LG   LD  ++  + C+I +T+P+L     +L ANR+          ++A+N GF V+Y +     C  C    G+CG  S SS   C+C ++
Sbjct:   33 NQQYEECTSSLYECGDMKGIGYPFWGDGRPKFCGQQGFELKCQNDDYPLIDIGSLEFRVLNISNSTYAMRIARKDFWDQTCPKEFQSTTLNYTLFDY-AGTDRNLTLFYGCPDDVLSQLPATWNISNNFTCSVEDINDTTAFYADEAFLG---LDQHLAILRTCKINVTLPVLGAAIDELNANRTGGEFSNGERLEKAMNMGFDVDY-SVVRGLCVHCNTTGGICGSSSTSSFS-CLCRDK 267          

Query:  949 TSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPP-PLSPDSAGTDKLVSSSTPPS 2013
            +SKS+ +    YFG+ +F YTELEEAT  F+P +E+GDGGFGTVY+G+L+DGR VAVKRLYENN +RVEQFMNEV+ILTRL HRNLV LYGCTSR SRELLLVYE+IPNGTVADHLHG R +SG L+WP+RLSIAIETA AL +LH +DV+HRDVKT NIL+D+ FCVKVADFGLSRLFP DVTHVSTAPQGTPGYVDPEY+QCYQLTDKSDVYSFGVVLIELISSL AVD NRHRH+INL+N AINKIQ    +EL+DP L F+++  V RM T VAELAFRCLQ +++MRP+MDEVL+ L+ I+++   SE+     +DI  D VG   + PP P SPD      L S    PS
Sbjct:  307 SSKSELEITGAYFGIPIFPYTELEEATNYFDPDREIGDGGFGTVYHGQLRDGREVAVKRLYENNHRRVEQFMNEVQILTRLRHRNLVSLYGCTSRHSRELLLVYEFIPNGTVADHLHGDRADSGLLTWPIRLSIAIETATALCYLHASDVVHRDVKTKNILLDDSFCVKVADFGLSRLFPTDVTHVSTAPQGTPGYVDPEYHQCYQLTDKSDVYSFGVVLIELISSLPAVDINRHRHEINLSNYAINKIQKCAFHELIDPRLGFDSDLAVNRMTTLVAELAFRCLQPDKEMRPSMDEVLEILKEIESDKHESEN-----MDIATDSVGSSMHEPPLPPSPDCDEVGLLKSVQLMPS 657          

Query:  901 STNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTDKLVSSSTPPS 2013
            ST LS++ S  S PS  S+   +   TYFG+ +F Y+ELEEAT +F P +E+GDGGFGTVY+G+L+DGR VAVKRLYENN++RVEQFMNEV+ILTRL HRNLV LYGCTSR SRELLLVYE+IPNGTVADHLHG R +SG L+WP+RLSIAIETA AL +LH +DV+HRDVKT NIL+DN FCVKVADFGLSRLFP DVTHVSTAPQGTPGYVDPEY+ C+QLTDKSDVYSFGVVLIELISSL AVD +R +H+INL+N AINKIQ    +EL+DP L F ++  V RM T VAELAFRCLQ +++MRP+MDEVL+ L+ I++     E+     +D  AD VG     PPP SPD      L S    PS
Sbjct:  977 STFLSRNTS--SDPS--SQPGLETTGTYFGIPIFPYSELEEATYHFVPDREIGDGGFGTVYHGQLRDGREVAVKRLYENNYRRVEQFMNEVQILTRLRHRNLVSLYGCTSRHSRELLLVYEFIPNGTVADHLHGNRADSGLLTWPIRLSIAIETASALCYLHASDVVHRDVKTKNILLDNSFCVKVADFGLSRLFPTDVTHVSTAPQGTPGYVDPEYHLCHQLTDKSDVYSFGVVLIELISSLPAVDFSRLKHEINLSNYAINKIQKCAFHELIDPHLGFNSDLAVNRMTTLVAELAFRCLQPDKEMRPSMDEVLEILKEIESNRHELEN-----MDAAADSVGSSMREPPPPSPDCDEVGLLKSVQLMPS 1338          

Query:  169 CGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYG-CNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRVCDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNE 1872
            CG   F+++C++++  LTIS   Y + Q+    +N  L  S+   + C     +  +  E F     D      F   C++ +    +    +C+           +     + ++++ KC   +  P  +        +  + +E +  GF + +     + C+ C    G CGF+       C C +R      +++                             + +        +     ST LS++ S  S PS  S+   +    YFG+ +F YTELEEAT  F+P +E+GDGGFG+VY+G+L+DGR VAVKRLYENN++RVEQFMNEV+ILTRL HRNLV LYGCTSR SRELLLVYE+IPNGTVADHLHG R +SG L+WP+RLSIAIETA AL +LH +DV+HRDVKT+NIL+DN FCVKVADFGLSRLFP DVTHVSTAPQGTPGYVDPEY+QCYQLTDKSDVYSFGVVLIELISSL AVD +RHRH+INL+N AINKIQ    +EL+DP L F+++  V RM T VAELAFRCLQ +++MRP+MDEVL+ L+ I+++
Sbjct:   30 CGYLGFNVSCLHNTTILTISENPYIIHQI--FYQNQTLRVSNALGNGCLPLGRDLLLPNEEFELAHPDGTDFFFFLSNCSAPLPDNLVRYKINCSGDDG-ASPVLAMSKGDSNWVLASEKCGREVKAPFEEKADD---GSNEIGEELVRRGFMLKWRA---SDCSVCEESGGKCGFNISDYHFKCFCPDRPHAKHCVSISRNDKTLKLALGLGIVGSIPFLIICFFIIRQR--------RKGKYASTFLSRNTS--SDPS--SQPGLETAGAYFGIAIFPYTELEEATNYFDPDREIGDGGFGSVYHGQLRDGREVAVKRLYENNYRRVEQFMNEVQILTRLRHRNLVSLYGCTSRHSRELLLVYEFIPNGTVADHLHGDRADSGLLTWPIRLSIAIETATALCYLHASDVVHRDVKTSNILLDNSFCVKVADFGLSRLFPTDVTHVSTAPQGTPGYVDPEYHQCYQLTDKSDVYSFGVVLIELISSLPAVDISRHRHEINLSNYAINKIQKCAFHELMDPHLGFDSDLAVNRMTTLVAELAFRCLQPDKEMRPSMDEVLEILKEIESD 577          

Query:  223 ISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNST-ITTPKLSNWFHCNNSLAFQDS----YYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRVCD---------PAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLH 1299
            + SL YRVL++D    NL L R DLW +TC  +  NST+    F Y   ++  +++FYGC+S  + TP     F+CN S +   +    YYL+GPVP DPI+   +C   + +P+L++ A  L AN     E +  GF VNY+NP + +C+ C+     CG+D D  EP+CIC +R+C          P  +                               +SK++PTP +SK +A   T  S+S  IPSYP   +KSD +KGSTYFGVQVFSY ELEEAT NF+P++ELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEV+ILTRL+H+NLVKLYGCTSRRSRELLLVYEYIPNGTVADHLH
Sbjct:    1 MKSLIYRVLRIDQTGENLTLTRLDLWNNTCPSQFANSTLNFTIFNYGMGNED-LNLFYGCDSVKLITPYKQ--FNCNASGSASGNSSYAYYLIGPVP-DPILKIIRCNTSLRIPVLQSAANSLTANNITLGEVLTVGFNVNYSNPCEAKCSACIAYGAQCGYDYDKEEPICICSDRICHVRGTGGNNVPKTVGYSVLGAVLLGIFLGCLFYFLAQRRRRASKAKSKDLPTPPSSKGIAPSLTGFSES--IPSYPY--TKSDIEKGSTYFGVQVFSYMELEEATNNFDPSRELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVQILTRLQHQNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLH 365          

Query:  991 VQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLH---RNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQ 1866
            + ++ Y  +E+AT +F+  + LG G +GTVY GKL + + VA+KR+   +   +E+ +NE+++++ + H NLV+L GC+  +  E +LVYE++ NGT++ HL  +R     L W VRLSIA +TA A+A LH      + HRD+K++NIL+D++F  K+ADFGLSRL   + +H+STAPQGTPGY+DP+Y+Q + L+DKSDVYSFGVVL+E+I++L+ VD +R ++++NLA +AI++I    ++E++DP LE   +         VAELAFRCL   RDMRP+M EV   L  I+
Sbjct:  309 IPIYPYRAIEKATSSFSEKQRLGTGAYGTVYSGKLHN-QWVAIKRIKHRDTDSIEEVLNEIKLISSVSHPNLVRLLGCSIEKG-EQILVYEFMANGTLSQHLQRERGNG--LVWAVRLSIATQTAQAIAHLHSALNPPIYHRDIKSSNILLDHNFIPKLADFGLSRLGMAESSHISTAPQGTPGYLDPQYHQNFHLSDKSDVYSFGVVLVEIITALKVVDFSRPQNEVNLAALAIDRIGKGRLDEIIDPFLEPHRDAWSLSSLHKVAELAFRCLAFHRDMRPSMMEVAAELEQIK 599          

Query: 1000 FSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVES-GFLSWPVRLSIAIETADALAFLHRNDV---IHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLD 1848
            F+  E++ AT +F+  + LG GG+G VY G L DG +VA+K     N K  +Q +NEV IL ++ HR+LV+L GC     + ++ VYE+IPNGT+ +HL G+R    G L+W  RL IA +TA+ LA+LH + V    HRDVK++NIL+D     KVADFGLSRL   D++HVST  QGT GY+DPEYY+ YQLTDKSDVYSFGVVL+EL++S +A+D NR   D+NLA      ++   + + +DPLL+ + + +      A+  LA  CL++ R  RP+M EV +
Sbjct:  328 FTGKEIKRATNSFSHDRLLGAGGYGEVYKGILDDGTIVAIKCAKLGNAKGTDQVLNEVGILCQVNHRSLVRLLGCCVELEQPIM-VYEFIPNGTLLEHLQGQRPGGRGSLTWSHRLRIAHDTAEGLAYLHSSAVPPIYHRDVKSSNILLDEKMNAKVADFGLSRLAHTDMSHVSTCAQGTLGYLDPEYYRNYQLTDKSDVYSFGVVLLELLTSQKAIDFNRPADDVNLAVYVQRTVEEERLMDAIDPLLKEQASSLELETMKAMGFLAVGCLEERRQNRPSMKEVTE 613          

Query:  994 QVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESG-FLSWPVRLSIAIETADALAFLHRNDV---IHRDVKTNNILIDNDFCVKVADFGLSRLF---PNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAI 1863
            ++FS  E++ AT NF+    +G GGF  V+ G L DG V AVKR    N K  +Q +NEV IL ++ HR LV+L GC     + ++ +YEYIPNGT+ DHLHG        L+W  RLSIA++TA+ LA+LH + V    HRDVK++NIL+D     KV+DFGLSRL      + +H++T  QGT GY+DPEYY+ +QLTDKSDVYSFGVVL+EL++S +A+D NR   D+NL       ++   + +++DP+L+   + V      A+  LA  CL + R  RP+M E  + +  I
Sbjct:  332 KIFSGKEIKRATNNFSKDNFIGSGGFSEVFKGILDDGTVTAVKRAKLGNTKGTDQVLNEVRILCQVNHRCLVRLLGCCVELEQPIM-IYEYIPNGTLFDHLHGHHSRKWPALTWRRRLSIALQTAEGLAYLHSSAVPPIYHRDVKSSNILLDEKLDAKVSDFGLSRLAVVSEANASHITTCAQGTLGYLDPEYYRNFQLTDKSDVYSFGVVLLELLTSKKAIDFNREEEDVNLVLYIKKIMKEEKLMDVIDPVLKDGASKVDMESVKALGLLAAACLDERRQSRPSMKEAAEEIEYI 627          

Query:   76 NANLSNCSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANR---SLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRVCDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLH--GKRVESGFLSWPVRLSIAIETADALAFLHR---NDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVS-TAPQGTPGYVDPEYYQCYQ---LTDKSDVYSFGVVLIELISSLQAVD 1641
            N    +C   ++CG +  +SYPF GGSR  YCG P F + C  ++PE T+   SYR+L ++     L +AR+D W S C     N+T+    F+YN +    V+++Y C      P  SN F+C N   +  +      + L+  +S   C + +TVPI ++ A  +V+     +L  EA+  GF + + N  ++ C +C+   G CG+ S+     C C N     +                                   + I  PL  K++          +++ ++         + GS     + ++Y+++++ T +F    +LG+GGFG VY GKL DGR++AVK L ++     + F+NEV  ++R  H N+V   G    RSR   L+YE++PNG++   ++  G   ES  L W     IA+  A  L +L+R     ++H D+K +NIL+D +F  K++DFGL++L     + VS T  +GT GY+ PE + C     ++ KSDVYS+G++++E++   + +D
Sbjct:   28 NQQFVSCGAQYECGNMV-ISYPFWGGSRPPYCGHPGFELTCDGEAPEFTMKEASYRILDINNSFHTLTVARADYWDSYCPPTYVNTTLNESIFSYNATYTD-VTLYYDCPQLTIAP--SNQFNCTNITGYYTT------LDLNLSVSPGSCGVYVTVPIFQSAATAIVSGGGTLTLLTEALKGGFGLEW-NASNSLCTECVESGGQCGYTSNQF--TCYCRNGYPLSSCQTTRSGSNVLRKIIIGIVAGVATLILVLAMLGCLRIIKCPLACKTLVFWKKESEDDENVEAFIR-------NYGS--LAPKRYNYSDVKKMTNSFT--SKLGEGGFGCVYKGKLPDGRMMAVKLLSKSK-GNGQDFINEVASISRTSHVNIVTFMGFCFERSRR-ALIYEFMPNGSLDKFIYNRGSSNESLNLEWKTMYQIAVGIARGLEYLYRGCNTRILHFDIKPHNILLDQNFIPKISDFGLAKLCQKTESMVSMTHARGTTGYIAPEVF-CRNFGGVSHKSDVYSYGMLVLEMVGGRKNID 534          

Query: 1000 FSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRN---DVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDI-NLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSP--DSAGTDKLVSSSTP 2007
            FS +E+E+AT  F   K++G GGFG VYYGK++DG+ +AVK L  N+++   +F NEV +L+R+ HRNLV+  G      R +L VYE++ NGT+ +HL+G       +SW  RL IA + A  + +LH      +IHRD+K++NIL+D     KV+DFGLS+L  +  +HVS+  +GT GY+DPEYY   QLTDKSDVYSFGV+L+ELIS  +A+       +  N+   A   I++  +  ++DP L  E  + ++ M   +AE A  C+Q    MRP + EV+  ++   + + G+E  +    D   + +    NM   + P  +    D+ ++  TP
Sbjct:  588 FSLSEIEDATRKFE--KKIGSGGFGVVYYGKMKDGKEIAVKVLINNSYQGNREFSNEVTLLSRIHHRNLVQFLGYCQEEGRSML-VYEFMHNGTLKEHLYGPLTRERAISWIKRLEIAEDAAKGIEYLHTGCVPSIIHRDLKSSNILLDKYMKAKVSDFGLSKLAVDGSSHVSSVVRGTVGYLDPEYYISQQLTDKSDVYSFGVILLELISGQEAISNESFGVNCRNIVQWAKLHIESGDIQGIIDPSLRDE--YDIQSM-WKIAEKALMCVQPHGSMRPPISEVIKEIQEAISIERGAEAAREGNSDASRNSIHSSINMGIDVGPTENYLSFDESIARPTP 923          

Query: 1003 SYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRN---DVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSE 1887
            S ++LEEAT+NF  AK++G G FG VYYGK+ DG+ +AVK + +++    +QF+ EV +L+R+ HRNLV L G      + LL VYEY+ NGT+ +H+H    +   L W  RL +A + A  L +LH      +IHRDVKT+NIL+D +   KV+DFGLSR    D+THVS+  +GT GY+DPEYY   QLT+KSDVYSFG+VL+ELIS  + V    +  + N+ + A + I N  V  +VDP L     +V       +AE+A  C++Q    RP M E++  ++     + G+E
Sbjct:  595 SLSDLEEATKNF--AKQIGRGSFGPVYYGKMPDGKEIAVKIMADSSSHGTQQFVTEVALLSRIHHRNLVPLIGYCEDEHQHLL-VYEYMHNGTLRNHIHDSTNQK-CLDWLGRLYVAEDAAKGLEYLHTGCNPSIIHRDVKTSNILLDINMRAKVSDFGLSRQAEEDLTHVSSVARGTVGYLDPEYYANQQLTEKSDVYSFGIVLLELISGRKPVSPEDYGAEWNIVHWARSLICNGDVISIVDPFL---LGNVKIESIWRIAEIAILCVEQHGTSRPKMQEIILAIQDAIKIERGNE 885          

Query:   58 TTSFPSNANLSNCSRV-FDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNST-ITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNG-LCGFDSDSSEPVCICGNRVCDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLS------------QSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTDKLVSSSTPPSS 2016
            TTS PS+A+LS+C+   F+CG +  LSYPFTGG R +YCGPP+FH+NC N+ PEL ISS+SYRVLQ++ V  +L LAR DLW  TCT    NST     F+ N   +  +++FYGC  T + T K  N F+C+++    +SY L+GP PLDP++   +C+ G+ VPIL+  A +   NRSL +E + EGF VNY NP++N C +C+   G  CGFDSD +E +CICGN +C P+G +                              + K    P+++     PS+  S             SQSIPSYPS  SK+     S YFGVQVF+Y ELEEAT NF+ +KELG+GGFGTVY G L+DGRVVAVKR YE+NFKRV QFMNEVEIL RL H+NLV LYGCTS+ SRELLLVYEYI NGTVADHLHG R  S  L W VRL IA+ETA+ALA+LH +DV+HRDVK+NNIL+D  F VKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVL+ELISSLQAVD  RHR+D+NLANMA+NKIQ+  + +LVDP L +E ++ V+RM TAVAELAFRCLQQ+RD+RP+MDE+++ LRAI++++  +++ + + + +  D++ LL+  P P SPDS     +  SST  SS
Sbjct:  519 TTSLPSHASLSSCNNTTFNCGHITKLSYPFTGGDRPSYCGPPQFHLNCKNNVPELNISSVSYRVLQVNSVTHSLTLARLDLWNETCTHHYVNSTFGGTSFS-NGLGNSKITLFYGCQPTSLFTEKPHNLFYCDSNGYKNNSYTLIGPFPLDPVLKFVQCDYGVGVPILEEQANRFAGNRSLLREVLMEGFNVNYNNPFENDCLECISSGGQQCGFDSDENEHICICGNGLC-PSGNSSTNGGLIGGVVGGVAALCLLGFVACFVVRRRRKNAKKPISNDLYMPPSSTTSGTNTGTLTSTTNSSQSIPSYPS--SKTSTMPKSFYFGVQVFTYEELEEATNNFHTSKELGEGGFGTVYKGDLKDGRVVAVKRHYESNFKRVAQFMNEVEILARLRHKNLVTLYGCTSKHSRELLLVYEYISNGTVADHLHGDRSSSCLLPWSVRLDIALETAEALAYLHASDVMHRDVKSNNILLDEKFHVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLVELISSLQAVDITRHRNDVNLANMAVNKIQSQELYDLVDPNLGYEKDNSVKRMTTAVAELAFRCLQQQRDLRPSMDEIVEVLRAIKSDEPETQESKVLDVVVRTDELVLLKKGPYPTSPDSVAEKWVSGSSTSTSS 1182          

Query:  103 VFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNST--ITTPKLSNWFHCNNSLAFQDSYYLLGPV-----PLDPIMSTFK-CEIGITVPILKTTAAKLVANRSL--FQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCIC 726
            +FDC  L+NL YPF G SR  YCG P F + C ++   +TI S +Y++L++      LK+ R+D W + C   + N+T+   FF Y  SD   ++++Y C  T  +     S  F+C+ +     +Y++L  V      LD    T + C+  + VP L++ A ++  N S+   ++ I+ GF V + N  ++ C +C    G CG++S S E  C C
Sbjct:  265 LFDCANLKNLRYPFWGSSRPQYCGHPSFELQCKDELASITIMSQNYKILEVSDSDHRLKVVRTDYWNNVCPTSLKNTTLDCTFFDYG-SDSHNLTLYYDCPHTPFLMPDSFSPQFNCSINGTQMVNYFMLESVADNAESLDSFSETLRTCKSRVVVPFLESEAERVATNSSVENLKDVIDNGFGVEW-NANNSLCHECQSSGGHCGYESSSREFTCFC 480          

Query:   88 SNCSRVFDCGP--LRNLSYPFTGGSRSAYCGP---PEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCT------DKVFNSTMK--PEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVC-------ICGNRVCDPAGLAV 762
            ++C+  F+CG   + NL YPF G +R   CG    P   + C    P++TI+ + YR+L+ D   + L +AR D W   CT      DK  NST +   +F  Y  S    +++ Y C++T+     S   +C  ++   +  Y L     DP   +  C + + + I    +   + N     EA+  GF + +   Y + C +C+   G CG +       C       ICG+R    + +++
Sbjct:   34 TDCNEAFECGSSSITNLKYPFWGNNREERCGSVSDPNMELTCEESVPKITINDVKYRILEWDNTTQKLTVARDDYWGGICTVSVSVSDKPNNSTFESADQFQPYG-SVSSQLNLLYNCDTTVLNVVYS--ANCGGNI---EVVYTLS----DPRSLSLTCNLSVIIAI--PISVTRITNLDDINEALQGGFDLRWMGNYAD-CQRCVDSGGACGNNGTEFRCFCNDGAYTDICGSRKAPTSSISL 265          

Query:   58 TTSFPSNANLSNCSRV-FDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNST-ITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNG-LCGFDSDSSEPVCICGNRVCDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLS------------QSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDS 1971
            TTS PS+A+LS+C+   F+CG +  LSYPFTGG R +YCGPP+FH+NC N+ PEL ISS+SYRVLQ++ V  +L LAR DLW  TCT    NST     F+ N   +  +++FYGC  T + T K  N F+C+++    +SY L+GP PLDP++   +C+ G+ VPIL+  A +   NRSL +E + EGF VNY NP++N C +C+   G  CGFDSD +E +CICGN +C P+G +                              + K    P+++     PS+  S             SQSIPSYPS  SK+     S YFGVQVF+Y ELEEAT NF+ +KELG+GGFGTVY G L+DGRVVAVKR YE+NFKRV QFMNEVEIL RL H+NLV LYGCTS+ SRELLLVYEYI NGTVADHLHG R  S  L W VRL IA+ETA+ALA+LH +DV+HRDVK+NNIL+D  F VKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVL+ELISSLQAVD  RHR+D+NLANMA+NKIQ+  + +LVDP L +E ++ V+RM TAVAELAFRCLQQ+RD+RP+MDE+++ LRAI++++  +++ + + + +  D++ LL+  P P SPDS
Sbjct:  519 TTSLPSHASLSSCNNTTFNCGHITKLSYPFTGGDRPSYCGPPQFHLNCKNNVPELNISSVSYRVLQVNSVTHSLTLARLDLWNETCTHHYVNSTFGGTSFS-NGLGNSKITLFYGCQPTSLFTEKPHNLFYCDSNGYKNNSYTLIGPFPLDPVLKFVQCDYGVGVPILEEQANRFAGNRSLLREVLMEGFNVNYNNPFENDCLECISSGGQQCGFDSDENEHICICGNGLC-PSGNSSTNGGLIGGVVGGVAALCLLGFVACFVVRRRRKNAKKPISNDLYMPPSSTTSGTNTGTLTSTTNSSQSIPSYPS--SKTSTMPKSFYFGVQVFTYEELEEATNNFHTSKELGEGGFGTVYKGDLKDGRVVAVKRHYESNFKRVAQFMNEVEILARLRHKNLVTLYGCTSKHSRELLLVYEYISNGTVADHLHGDRSSSCLLPWSVRLDIALETAEALAYLHASDVMHRDVKSNNILLDEKFHVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLVELISSLQAVDITRHRNDVNLANMAVNKIQSQELYDLVDPNLGYEKDNSVKRMTTAVAELAFRCLQQQRDLRPSMDEIVEVLRAIKSDEPETQESKVLDVVVRTDELVLLKKGPYPTSPDS 1167          

Query:  103 VFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNST--ITTPKLSNWFHCNNSLAFQDSYYLLGPV-----PLDPIMSTFK-CEIGITVPILKTTAAKLVANRSL--FQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCIC 726
            +FDC  L+NL YPF G SR  YCG P F + C ++   +TI S +Y++L++      LK+ R+D W + C   + N+T+   FF Y  SD   ++++Y C  T  +     S  F+C+ +     +Y++L  V      LD    T + C+  + VP L++ A ++  N S+   ++ I+ GF V + N  ++ C +C    G CG++S S E  C C
Sbjct:  265 LFDCANLKNLRYPFWGSSRPQYCGHPSFELQCKDELASITIMSQNYKILEVSDSDHRLKVVRTDYWNNVCPTSLKNTTLDCTFFDYG-SDSHNLTLYYDCPHTPFLMPDSFSPQFNCSINGTQMVNYFMLESVADNAESLDSFSETLRTCKSRVVVPFLESEAERVATNSSVENLKDVIDNGFGVEW-NANNSLCHECQSSGGHCGYESSSREFTCFC 480          

Query:   88 SNCSRVFDCGP--LRNLSYPFTGGSRSAYCGP---PEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCT------DKVFNSTMK--PEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVC-------ICGNRVCDPAGLAV 762
            ++C+  F+CG   + NL YPF G +R   CG    P   + C    P++TI+ + YR+L+ D   + L +AR D W   CT      DK  NST +   +F  Y  S    +++ Y C++T+     S   +C  ++   +  Y L     DP   +  C + + + I    +   + N     EA+  GF + +   Y + C +C+   G CG +       C       ICG+R    + +++
Sbjct:   34 TDCNEAFECGSSSITNLKYPFWGNNREERCGSVSDPNMELTCEESVPKITINDVKYRILEWDNTTQKLTVARDDYWGGICTVSVSVSDKPNNSTFESADQFQPYG-SVSSQLNLLYNCDTTVLNVVYS--ANCGGNI---EVVYTLS----DPRSLSLTCNLSVIIAI--PISVTRITNLDDINEALQGGFDLRWMGNYAD-CQRCVDSGGACGNNGTEFRCFCNDGAYTDICGSRKAPTSSISL 265          

Query:   58 TTSFPSNANLSNCSRV-FDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNST-ITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNG-LCGFDSDSSEPVCICGNRVCDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLS------------QSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDS 1971
            TTS PS+A+LS+C+   F+CG +  LSYPFTGG R +YCGPP+FH+NC N+ PEL ISS+SYRVLQ++ V  +L LAR DLW  TCT    NST     F+ N   +  +++FYGC  T + T K  N F+C+++    +SY L+GP PLDP++   +C+ G+ VPIL+  A +   NRSL +E + EGF VNY NP++N C +C+   G  CGFDSD +E +CICGN +C P+G +                              + K    P+++     PS+  S             SQSIPSYPS  SK+     S YFGVQVF+Y ELEEAT NF+ +KELG+GGFGTVY G L+DGRVVAVKR YE+NFKRV QFMNEVEIL RL H+NLV LYGCTS+ SRELLLVYEYI NGTVADHLHG R  S  L W VRL IA+ETA+ALA+LH +DV+HRDVK+NNIL+D  F VKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVL+ELISSLQAVD  RHR+D+NLANMA+NKIQ+  + +LVDP L +E ++ V+RM TAVAELAFRCLQQ+RD+RP+MDE+++ LRAI++++  +++ + + + +  D++ LL+  P P SPDS
Sbjct:  519 TTSLPSHASLSSCNNTTFNCGHITKLSYPFTGGDRPSYCGPPQFHLNCKNNVPELNISSVSYRVLQVNSVTHSLTLARLDLWNETCTHHYVNSTFGGTSFS-NGLGNSKITLFYGCQPTSLFTEKPHNLFYCDSNGYKNNSYTLIGPFPLDPVLKFVQCDYGVGVPILEEQANRFAGNRSLLREVLMEGFNVNYNNPFENDCLECISSGGQQCGFDSDENEHICICGNGLC-PSGNSSTNGGLIGGVVGGVAALCLLGFVACFVVRRRRKNAKKPISNDLYMPPSSTTSGTNTGTLTSTTNSSQSIPSYPS--SKTSTMPKSFYFGVQVFTYEELEEATNNFHTSKELGEGGFGTVYKGDLKDGRVVAVKRHYESNFKRVAQFMNEVEILARLRHKNLVTLYGCTSKHSRELLLVYEYISNGTVADHLHGDRSSSCLLPWSVRLDIALETAEALAYLHASDVMHRDVKSNNILLDEKFHVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLVELISSLQAVDITRHRNDVNLANMAVNKIQSQELYDLVDPNLGYEKDNSVKRMTTAVAELAFRCLQQQRDLRPSMDEIVEVLRAIKSDEPETQESKVLDVVVRTDELVLLKKGPYPTSPDS 1167          

Query:  103 VFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNST--ITTPKLSNWFHCNNSLAFQDSYYLLGPV-----PLDPIMSTFK-CEIGITVPILKTTAAKLVANRSL--FQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCIC 726
            +FDC  L+NL YPF G SR  YCG P F + C ++   +TI S +Y++L++      LK+ R+D W + C   + N+T+   FF Y  SD   ++++Y C  T  +     S  F+C+ +     +Y++L  V      LD    T + C+  + VP L++ A ++  N S+   ++ I+ GF V + N  ++ C +C    G CG++S S E  C C
Sbjct:  265 LFDCANLKNLRYPFWGSSRPQYCGHPSFELQCKDELASITIMSQNYKILEVSDSDHRLKVVRTDYWNNVCPTSLKNTTLDCTFFDYG-SDSHNLTLYYDCPHTPFLMPDSFSPQFNCSINGTQMVNYFMLESVADNAESLDSFSETLRTCKSRVVVPFLESEAERVATNSSVENLKDVIDNGFGVEW-NANNSLCHECQSSGGHCGYESSSREFTCFC 480          

Query:   88 SNCSRVFDCGP--LRNLSYPFTGGSRSAYCGP---PEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCT------DKVFNSTMK--PEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVC-------ICGNRVCDPAGLAV 762
            ++C+  F+CG   + NL YPF G +R   CG    P   + C    P++TI+ + YR+L+ D   + L +AR D W   CT      DK  NST +   +F  Y  S    +++ Y C++T+     S   +C  ++   +  Y L     DP   +  C + + + I    +   + N     EA+  GF + +   Y + C +C+   G CG +       C       ICG+R    + +++
Sbjct:   34 TDCNEAFECGSSSITNLKYPFWGNNREERCGSVSDPNMELTCEESVPKITINDVKYRILEWDNTTQKLTVARDDYWGGICTVSVSVSDKPNNSTFESADQFQPYG-SVSSQLNLLYNCDTTVLNVVYS--ANCGGNI---EVVYTLS----DPRSLSLTCNLSVIIAI--PISVTRITNLDDINEALQGGFDLRWMGNYAD-CQRCVDSGGACGNNGTEFRCFCNDGAYTDICGSRKAPTSSISL 265          

Query:  223 ISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNST-ITTPKLSNWFHCNNSLAFQDS----YYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRVCD---------PAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTDKLVSSSTPPS 2013
            + SL YRVL++D    NL L R DLW +TC  +  NST+    F Y   ++  +++FYGC+S  + TP     F+CN S +   +    YYL+GPVP DPI+   +C   + +P+L++ A  L AN     E +  GF VNY+NP + +C+ C+     CG+D D  EP+CIC +R+C          P  +                               +SK++PTP +SK +A   T  S+S  IPSYP   +KSD +KGSTYFGVQVFSY ELEEAT NF+P++ELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEV+ILTRL+H+NLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGK+  SG ++WPVRLSIAIETA+ALA+LH +++IHRDVKTNNIL+DN+F VKVADFGLSRLFP DVTHVSTAPQGTPGYVDPEY+QCYQLT KSDVYSFGVVL+ELISS QAVDTNRHRHDINLANMA+NKI NH ++ELVDP L FE++ +VRR  T VAELAFRCLQ ERDMRPTM EVL  LR I+NE+  S+  +A  +DI ++D+GLL++ PPP+SPDS   DK V+ +TP S
Sbjct:    1 MKSLIYRVLRIDQTGENLTLTRLDLWNNTCPSQFANSTLNFTIFNYGMGNED-LNLFYGCDSVKLITPYKQ--FNCNASGSASGNSSYAYYLIGPVP-DPILKIIRCNTSLRIPVLQSAANSLTANNITLGEVLTVGFNVNYSNPCEAKCSACIAYGAQCGYDYDKEEPICICSDRICHVRGTGGNNVPKTVGYSVLGAVLLGIFLGCLFYFLAQRRRRASKAKSKDLPTPPSSKGIAPSLTGFSES--IPSYPY--TKSDIEKGSTYFGVQVFSYMELEEATNNFDPSRELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVQILTRLQHQNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKQANSGSITWPVRLSIAIETANALAYLHESEIIHRDVKTNNILLDNNFQVKVADFGLSRLFPTDVTHVSTAPQGTPGYVDPEYHQCYQLTSKSDVYSFGVVLMELISSKQAVDTNRHRHDINLANMAVNKILNHTLHELVDPSLGFESDSLVRRKITLVAELAFRCLQHERDMRPTMGEVLKALRRIENEE--SDVQKAEEVDINSEDIGLLKSNPPPVSPDSVVADKGVNPTTPYS 601          

Query:   58 TTSFPSNANLSNCSRV-FDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDS-PELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNST---ITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRVCDPAGL-------------------------AVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVES-GFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNED-LGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTDKLVSSSTPPSS 2016
            TTS P +A LS+C    F+CG + NLSYPFTGG R ++CGPP+F +NC N    EL ISS+SYRV+ +D     L LAR DLW  TCTD   NST     F+Y   +   +++FY C  T   I TP+  N F+C ++    +SY L+GP PLDPI+   +C+  + VPILK  A +LV NRSL  E + +GF VNY NPY+++C +CL   G+CGFDSD+ E +CICG+ +C   G                           +                  Q          +S E+    +S      +TN SQS S  SY S ++       S YFGVQVF+Y ELEEAT+NF+ ++ELG+GGFGTVY G+L+DGRVVAVKR YE+N +R+EQFMNEV+IL RL H++LV L+GCTSR SRELLLVYE+IPNGTVADHL G+   S   L WPVRL+IA+ETA+ALA+LH NDVIHRDVKTNNIL+D++F VKVADFGLSR FPN VTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVL+ELISSLQAVD NR+R D+NLANMAINKIQN  ++ELVDP L FE ++ +RRM T VAELAFRCLQQER++RP+M+EV++ LR I+++D LG+ + +  VL++  D+  LL+ +  P+SPDS   DK  S S+  +S
Sbjct:   19 TTSLPPHATLSSCHVTSFNCGSITNLSYPFTGGDRPSFCGPPQFLLNCRNGVVAELNISSVSYRVIDIDSEDHTLTLARLDLWNETCTDVYVNSTFDGPVFSYGSGNQ-NLTLFYECKPTSRIIETPE--NLFNCWSNGDKNNSYSLVGPFPLDPILEVVECDEHVKVPILKVQADRLVENRSLLGEVLMKGFNVNYMNPYESECFECLDSGGVCGFDSDNDEHICICGDHLCATPGCFYYKINKVGVAIGNFLFVNFLNFTNVIIGAVVALVVILGCVYFVMQRRRKTAYNKQRSMELFIAPSSGDTFASTTNTSQSLS--SYQS-SNTDPMPPRSYYFGVQVFTYEELEEATKNFDSSRELGEGGFGTVYKGQLKDGRVVAVKRHYESNSRRIEQFMNEVQILARLRHKSLVTLFGCTSRHSRELLLVYEFIPNGTVADHLQGRSSNSTNLLPWPVRLNIAVETAEALAYLHANDVIHRDVKTNNILLDDNFRVKVADFGLSRDFPNHVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLVELISSLQAVDINRNRSDVNLANMAINKIQNQELHELVDPYLGFERDYAIRRMTTGVAELAFRCLQQEREIRPSMNEVVEILRGIKSDDGLGARE-ETEVLEVRIDEARLLKKV-SPVSPDSV-VDKCFSGSSVSNS 694          

Query:   58 TTSFPSNANLSNCSRV-FDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDS-PELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCN-STITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRVCDPAG---------LAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVES-GFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNED-LGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTDKLVSSSTPPSS 2016
            TTS P +A LS C    F+CG + NLSYPFTGG R ++CGPP+FH+NC N   PEL ISS+SYRV+ ++     L LAR DLW  TCT+   NST     F+Y   +   +++FY C  S+  T    N FHC ++    +SY L+GP PLDPI+   +C+  + VPIL   A +LV NRSL  E + +GF VNY NPY+ +C +CL   G+CGFDSD+ EP+CICG+++C   G          +V                  +           S ++  P +S      +TN SQS S  SY S ++       S YFGVQVF+Y ELEEAT+NF+ +KELG+GGFGTVY G+L+DGRVVAVKR YE+N +R+EQFMNEV+IL RL H++LV L+GCT R SRELLLVYE+IPNGTVADHL G+  +S   L WP+RL+IA+ETA+ALA+LH   VIHRDVKTNNIL+D++F VKVADFGLSR FPN VTHVSTAPQGTPGYVDPEYYQ YQLTDKSDVYSFGVVL+ELISSLQAVD NR+R D+NLANMAINKIQN  + E VDP L FE ++ +RRM T VAELAFRCLQQER++RP+M+EV++ LR I + D LG+ + +  VL++  D+  LL+    P+SPDS   DK VS S+  +S
Sbjct:   23 TTSLPPHAQLSTCHVTSFNCGTITNLSYPFTGGDRPSFCGPPQFHLNCQNGIVPELIISSVSYRVIHVNSEAHTLNLARLDLWNETCTNVYVNSTFDGPTFSYGSGNQ-NLTLFYECEASSRITETPENLFHCWSNGDKNNSYSLVGPFPLDPILEVVECDEHVKVPILIELADRLVKNRSLLGEVLMKGFNVNYMNPYETECFECLASGGVCGFDSDNDEPICICGDQLCATPGSSKVAVAIGASVGAVGALVVILGCVYFVLQRRRKIAYNKQRSSMDLFMPPSSGDTFASTTNTSQSLS--SYQS-SNTDPMPPRSNYFGVQVFTYEELEEATKNFDSSKELGEGGFGTVYKGELKDGRVVAVKRHYESNSRRIEQFMNEVQILARLRHKSLVTLFGCTHRHSRELLLVYEFIPNGTVADHLQGRSTKSTNLLPWPIRLNIAVETAEALAYLHAKGVIHRDVKTNNILLDDNFRVKVADFGLSRDFPNHVTHVSTAPQGTPGYVDPEYYQSYQLTDKSDVYSFGVVLVELISSLQAVDINRNRSDVNLANMAINKIQNQELLEFVDPYLGFERDYAIRRMTTGVAELAFRCLQQEREIRPSMNEVVEILRGINSSDGLGARE-ETKVLEVRTDEAILLK--VSPVSPDSV-VDKWVSGSSVSNS 681          

Query:   91 NCSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKL---SNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFK-CEIGITVPILKTTAAKLV--ANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDS-DSSEPVCICGNRVCDP--------AGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTDKLVSSST 2004
            NCS+ F+CG + ++ YPF G +R  YCG PEF +NC   +  +TI  L+Y+VL+++   + LK+AR+D   + C     ++T+   +F+Y  SD   ++++YGC  +   P L   +N F CN+S  F  +  L        +M+ F+ C++ + VP  ++ A  L    N+     A+ +GF + +    ++ C  C    G CG +S D S   C C N   DP        +G+ +                  Q          ++K++PTP +SKS   P  N SQ+   PSY S  SKSD +KGSTYFG +VFSY EL EAT+NF+P+KELGDGGFGTVYYG L DGRVVAVKRL+ENN KR EQFMNE+EILTRL H+NLV LYGCTS+RSREL+LVYEYIPNGT+ADH+HG R +SG L+W VRLSIAIETADALA+LH +DVIHRDVKTNNIL+DN+F VKVADFGLSRLFPND THVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVL+ELISSLQAVDTNRHR DINLANMA+NKIQNH +NELVDP+L ++ ++ VR+M T+VAELAFRCLQQE+DMRPTM EVL+ L+ I++ED GSE  +A  LDI  DDV LL ++ P    +S  TDK VSSS+
Sbjct:   38 NCSQKFECGNITDIGYPFWGSNRPQYCGHPEFELNCTGQTAVITIEELTYQVLEINSEEKTLKVARTDYIDNICPSNPVSTTLNFNYFSYT-SDIQNITLYYGCPQSNPMPTLQDFTNQFSCNDSNGFFVTRNLSNLTAA--LMTYFRTCDVEVIVPANQSAAQSLENRPNQENLVIALEQGFGLEWRE--NSTCETCNISGGQCGSNSTDPSLFACYCTNGP-DPFSCGRSQSSGVGIAGAVVIGIGLGCWIFLYVQRKKRIAAQT-KNKDLPTPPSSKSQPAPVINFSQTT--PSYSS--SKSDLEKGSTYFGTKVFSYEELVEATDNFDPSKELGDGGFGTVYYGILSDGRVVAVKRLFENNMKRAEQFMNEIEILTRLRHKNLVTLYGCTSKRSRELVLVYEYIPNGTLADHIHGNRSKSGLLTWKVRLSIAIETADALAYLHASDVIHRDVKTNNILLDNNFRVKVADFGLSRLFPNDCTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLVELISSLQAVDTNRHRLDINLANMAVNKIQNHAINELVDPMLGYDKDYAVRKMTTSVAELAFRCLQQEKDMRPTMAEVLEALKKIESEDYGSEKTEA--LDIKEDDVVLLNHVAPFSPDESVTTDKWVSSSS 677          

Query:  106 FDCGPLRNLSYPF-TGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNW-----FHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRV----CDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSV------ATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDI--GADDVGLLRNMPPPLSPDSAGTDKLVSSSTPPSS 2016
            F CG + N+ YPF +   + +YCG P+F ++C  D+  + + S  + V+ +D   + LK+AR DLW   CT++  N  +  +FF Y  +DD Y ++ Y C   +T     N      F C     F+D+++ LG            C+  I V +L+      +   ++ ++    GF +N+T P    C  C    G CGFD +    +C C ++     C                                       ++P     K        +T  ++L+   + PS  S  + +D  K     GV +F Y ELEEAT  F+ +KELG+GGFGTVY+GKL+DGR VAVKRLYENNFKRV QFMNE++IL +L H NLVKLYGCTSR SRELLLVYEYIPNGTVADHLHG+R + G L W +R+ IA+ETA AL FLH  DVIHRDVKTNNIL+D+DFCVKVADFGLSRLFP+ VTHVSTAPQGTPGYVDPEY+QCYQLT +SDVYSFGVVL+ELISSL AVD  RHRH+INL+NMAINKI N  ++ELVDP L FE++  VR+M  AVAELAF+CLQ  ++MRP+M+EV++ L+ IQ++  G    Q  V+DI   ADDV LL++ PPP SPDS      VS ST P++
Sbjct:   40 FSCGEIDNIRYPFWSSDHQQSYCGHPKFKLDCQQDNVTIDMMSQRFHVIDIDQTSKVLKMARLDLWDDPCTNEYSNVKLDSDFFNYTSNDDDY-TLLYDCGPPVTYTSSVNIKGTISFSCPIDSGFRDAFFDLG------------CKHSINVSVLREAVKDALQVENVLEKGFEMGFVLNWTAP---DCHYCEKSGGRCGFDGNQF--LCFCKDKSYLKSCGSGNNTFWKYCDYTFVVCSAGTFLCNILTKVYQIVAFPFDLPLVKVHKYTCLCLLHSTTISSLNWHNANPSLLSLLTVADPRKLRLIIGVPLFLYDELEEATNYFDSSKELGEGGFGTVYFGKLRDGRSVAVKRLYENNFKRVAQFMNEIKILAKLVHPNLVKLYGCTSRHSRELLLVYEYIPNGTVADHLHGQRSKPGKLPWHIRMKIAVETASALNFLHHKDVIHRDVKTNNILLDSDFCVKVADFGLSRLFPDHVTHVSTAPQGTPGYVDPEYHQCYQLTKQSDVYSFGVVLVELISSLPAVDITRHRHEINLSNMAINKIHNQALHELVDPTLGFESDFKVRKMINAVAELAFQCLQSSKEMRPSMEEVVETLKDIQSD--GKHKSQPEVMDITSTADDVVLLKDDPPPPSPDS----NAVSKSTTPNA 670          

Query:  109 DCGPLRNLSYPF-TGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTS-TCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNS----TITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPI-MSTFKCEIGITVPILKTTAAKLVAN--RSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNR---------VCDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTD 1983
            +CG   N+SYPF     + +YCG P F I C ++ P LTIS   Y + ++     +  ++ S ++   +C   + N ++    F Y+ S    + +FY C S    T+T P       C ++     S+       L+ +  ST  C+  + VP+      +   N     F E + EGF +++T    N C+ C    G CGF+++  E +C C +R         VC  AGL                                 K  P PL S++++             S PS  SK+ ++   +  GV +F+Y ELEEAT NF+ +KELGDGGFGTVY+GKL+DGRVVAVKRLYENN+KRVEQFMNEVEIL  L HRNLV LYGCTSR SRELLLVYEY+PNGTVADHLHG++ + G L+WP R+ IAIETA AL +LH +D+IHRDVKTNNIL+D++F VKVADFGLSRLFP DVTHVSTAPQGTPGYVDP+Y+QCYQLT KSDVYSFGVVLIELISS+ AVD  RHRH+INL+NMAINKIQNH ++ELVD  L F+++  +RRM  AVAELAF+CLQ E++MRP MDEVL+ L  I++E  G    +   ++I AD VGLL++  PP SPDS  T+
Sbjct:  355 NCGTGPNVSYPFWIPKEQESYCGFPNFSITCNDEKPVLTISDDYYVIREIFYTNHSFLMSNSAVYDGDSCPTPLHNFSLDRTPFNYSPSH-YDLLLFYNCTSVPVETLTIP-----IDCMSNATLH-SFASFHEEALEYMNFSTESCQSMVNVPV-DIDGEEGFGNLLNWNFTEILREGFVLSWTA---NNCSSCERSGGRCGFENN--EFICFCQDRPHLRTCHDGVC--AGLGTLLI---------------SSIFFLMYLRRYKKRYPPPLFSRNIS-------------SDPS--SKTIFESQGSLHGVHIFTYEELEEATNNFDSSKELGDGGFGTVYHGKLRDGRVVAVKRLYENNYKRVEQFMNEVEILQLLRHRNLVSLYGCTSRHSRELLLVYEYVPNGTVADHLHGEQAKPGSLTWPTRMKIAIETASALKYLHASDIIHRDVKTNNILLDSNFSVKVADFGLSRLFPTDVTHVSTAPQGTPGYVDPDYHQCYQLTSKSDVYSFGVVLIELISSMPAVDITRHRHEINLSNMAINKIQNHALHELVDRSLGFDSDQNIRRMIMAVAELAFQCLQNEKEMRPAMDEVLEVLMGIESE--GCNIVKTEEVEIPADSVGLLKSKQPPASPDSVTTN 950          

Query:   76 NANLSNC-SRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDS-PELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTI-----TTPKLSNWFHC-----NNSLAFQDSYYLLGPVPLDPIMSTFK-CEIGITVPILKTTAAKLVANRS--------LFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNR 735
            N     C S +++CG ++ + YPF G  R  +CG   F + C ND  P + I SL +RVL +      +++AR D W  TC  +  ++T+    F Y    D  +++FYGC   +      T  +SN F C     N++ AF      LG   LD  ++  + C+I +T+P+L     +L ANR+          ++A+N GF V+Y +     C  C    G+CG  S SS   C+C ++
Sbjct:   33 NQQYEECTSSLYECGDMKGIGYPFWGDGRPKFCGQQGFELKCQNDDYPLIDIGSLEFRVLNISNSTYAMRIARKDFWDQTCPKEFQSTTLNYTLFDY-AGTDRNLTLFYGCPDDVLSQLPATWNISNNFTCSVEDINDTTAFYADEAFLG---LDQHLAILRTCKINVTLPVLGAAIDELNANRTGGEFSNGERLEKAMNMGFDVDY-SVVRGLCVHCNTTGGICGSSSTSSFS-CLCRDK 267          

Query:   91 NCSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFY-GCNSTITT------PKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSL--FQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRVCDP-----------AGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFT-----------SKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDI-GADDVGLLRN-MPPPLSPDSAGTDKLV--SSSTPPSSF 2019
            +CS  F CG    L YPF    R   CG P+F +NC  D  ELT+S++ +++L+++     ++LAR D   + C     N+++  +   +  S D  +S FY  C ST+         +L+   +      F  S    G       +S   CE G+ +P+ ++    +  N+SL   ++AI+EGF + +    +N+C+QC    G CGFD      VC C +   +            AGL+                              + K++ T  T+K ++T +T  S + ++ + P+ T           S S+   GS Y G+QVFSY ELEEATENF+  KELGDGGFGTVYYG L+DGR VAVKRL+E + KRVEQF NE++IL  L+H NLV LYGCT+R SRELLLVYEYI NGT+A+HLHG + +S  + WP RL IAIETA AL++LH + +IHRDVKT NIL+D+++ VKVADFGLSRLFP D TH+STAPQGTPGYVDPEYYQCY+L +KSDVYSFGVVL ELISS +AVD  RHRHDINLANMAI+KIQN  V+EL D  L F  +  V++M ++VAELAFRCLQQERD+RP+MDE+++ LR IQ + +       V +D+ G DDVGLL++ +PPPLSP+   TDK    SS+T  SSF
Sbjct:  317 HCSPRFKCGNQSELYYPFWISERKE-CGHPDFEVNCSGDFAELTVSTVKFQILEMNYEFEIIRLARMDYRNNLCPQHPANASINHDVLPF--SPDTKLSTFYHDCQSTVDVHPNDYIKQLNCEDYIGGKSYFVSSSSHSGDRATLAALSA-SCE-GVDIPVSRSALKTVEKNQSLEAMKKAIDEGFELGF----NNECSQCAISGGACGFDQRLKAFVCYCADEPHESTCYSEIVKKTHAGLSKKGKIGIGFASGFLGATLI-GGCLLCIFIRRRKKLATQYTNKGLST-TTPYSSNYTMSNTPTSTTISGSNHSLVPSISNLGNGSVYSGIQVFSYEELEEATENFS--KELGDGGFGTVYYGTLKDGRAVAVKRLFERSLKRVEQFKNEIDILKSLKHPNLVILYGCTTRHSRELLLVYEYISNGTLAEHLHGNQAQSRPICWPARLQIAIETASALSYLHASGIIHRDVKTTNILLDSNYQVKVADFGLSRLFPMDQTHISTAPQGTPGYVDPEYYQCYRLNEKSDVYSFGVVLSELISSKEAVDITRHRHDINLANMAISKIQNDAVHELADLSLGFARDPSVKKMMSSVAELAFRCLQQERDVRPSMDEIVEVLRVIQKDGISDSKDVVVEIDVNGGDDVGLLKHGVPPPLSPE---TDKTTASSSNTTASSF 978          

Query:   94 CSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVN--DSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEI-GITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVC 720
            C  +F CG L    +PF G +R   CG P   ++C    +S  L ISSL YRVL+++     LKL R D     C+     +T+ PE F     D   +S +Y CN ++  P     F C N          +G +  D +       I  ITVPI      +   N +  +  + +GF V  +   +  C +C    G+C +    + PVC
Sbjct:   38 CDTLFRCGDL-TAGFPFWGVARPQPCGHPSLGLHCQKQTNSTSLIISSLMYRVLEVNTTTSTLKLVRQDFSGPFCSASFSGATLTPELFEL-LPDYKTLSAYYLCNPSLHYPAK---FICPNK--------GVGSIHQDDLYHNHCGGIFNITVPI-GYAPEEGALNVTNLESVLKKGFEVKLSID-ERPCQECKTNGGICAY--HVATPVC 232          

Query:  112 CGPLRNLSYPF-TGGSRSAYCGPPEFHINCVNDS--PELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPL--DPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCIC--GNRVCDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQS-QSIPSYPSFTSKSDYDKGSTYF-GVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSE 1887
            CG    +SYPF   G + ++CG P F + C ++   P L IS   Y +  +  + ++ ++  S      C   + N T+    F  N S  I  +I Y C+  +     +    C  + +   S+ +     L  +  +++  C+  + VP+L +  + ++     + E +  GF +N+T    N C +C+   G CG  +D  E VC+C  G ++ D                                       +     +KS    S  L ++  S PS  SF    D +K      GV +FSY ELEEAT NF+P+KELGDGGFGTVYYGKL+DGR VAVKRLY+NNFKR EQF NEVEILT L H NLV L+GC+S++SR+LLLVYEY+ NGT+ADHLHG +     L W +RL IA+ETA AL +LH + +IHRDVK+NNIL+D +F VKVADFGLSRLFP D THVSTAPQGTPGYVDP+Y+ CYQL++KSDVYSF VVL+ELISSL AVD  R R +INL+NMA+ KIQNH + ++VDP L F+T+  VR+   AVAELAF+CLQ ++D+RP M  V D L  IQN   GSE
Sbjct:   39 CGKGPQISYPFYLSGKQESFCGYPSFELTCDDEEKLPVLGISGEEYVIKNISYLTQSFQVVNSKASHDPCPRPLNNLTLHRTPFFVNPSH-INFTILYNCSDHLLEDFRTYPLTCARNTSLLRSFGVFDRKKLGKEKQIASMSCQKLVDVPVLASNESDVMG--MTYVEILKRGFVLNWTA---NSCFRCITSGGRCG--TDQQEFVCLCPDGPKLHDTCTNGKNDKRRRVIVKITKSISGASAAVVGLIAASIFWYVYHRRKTKSYRNSSALLPRNISSDPSAKSF----DIEKAEELLVGVHIFSYEELEEATNNFDPSKELGDGGFGTVYYGKLKDGRSVAVKRLYDNNFKRAEQFRNEVEILTGLRHPNLVALFGCSSKQSRDLLLVYEYVANGTLADHLHGPQANPSSLPWSIRLKIAVETASALKYLHASKIIHRDVKSNNILLDQNFNVKVADFGLSRLFPMDKTHVSTAPQGTPGYVDPDYHLCYQLSNKSDVYSFAVVLMELISSLPAVDITRPRQEINLSNMAVVKIQNHELRDMVDPSLGFDTDTRVRQTVIAVAELAFQCLQSDKDLRPCMSHVQDTLTRIQNNGFGSE 627          

Query:  922 QSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRN---DVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQ------NEDLGSEDGQAVVLDIGAD------DVGLLRNMPPPLSPDSAGTDKLVSSSTPPS 2013
            +S P     ++K    + +    V  F Y E+E+AT+ F+  ++LG G +GTVY GKLQ+   VA+KRL   + + ++Q MNE+++L+ + H NLV+L GC   +  + +LVYEY+PNGT+++HL  +R     L W +RL++A +TA A+A+LH +    + HRD+K+ NIL+D DF  KVADFGLSRL   + +H+STAPQGTPGY+DP+Y+QC+ L+DKSDVYSFGVVL E+I+ L+ VD  R   +INLA +A++KI +  ++E++DP+L+ + +         VAELAFRCL    DMRPTM EV D L  I+      +  L S  G     D G++       +G  R + P   PD   + + +S S+P S
Sbjct:  310 RSTPLRSHLSAKRLLSEAAGNSSVAFFPYKEIEKATDGFSEKQKLGIGAYGTVYRGKLQNDEWVAIKRLRHRDSESLDQVMNEIKLLSSVSHPNLVRLLGCCIEQG-DPVLVYEYMPNGTLSEHL--QRDRGSGLPWTLRLTVATQTAKAIAYLHSSMNPPIYHRDIKSTNILLDYDFNSKVADFGLSRLGMTESSHISTAPQGTPGYLDPQYHQCFHLSDKSDVYSFGVVLAEIITGLKVVDFTRPHTEINLAALAVDKIGSGCIDEIIDPILDLDLDAWTLSSIHTVAELAFRCLAFHSDMRPTMTEVADELEQIRLSGWIPSMSLDSPAGSLRSSDRGSERSVKQSSIGSRRVVIPQKQPDCLASVEEISDSSPIS 685          

Query:  991 VQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRN---DVIHRDVKTNNILIDNDFCVKVADFGLSRLFPN---DVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQ 1896
            V  ++Y E+E+AT++F+    LG G +GTVY G+  +   VA+KRL   +   ++Q +NE+++L+ + H NLV+L GC      E  LVYE++PNGT+  HL  +R +   LSW +RL+IA +TA+A+A LH +    + HRD+K++NIL+D++F  K++DFGLSRL  +   + +H+STAPQGTPGY+DP+Y+Q +QL+DKSDVYSFGVVL+E+IS  + +D  R   ++NLA++A+++I    V +++DP L  E N  +      +AELAFRCL   R+MRPTM E+ + L  I+    G+E G+
Sbjct:  299 VPFYTYKEIEKATDSFSDKNMLGTGAYGTVYAGEFPNSSCVAIKRLKHKDTTSIDQVVNEIKLLSSVSHPNLVRLLGCCFADG-EPFLVYEFMPNGTLYQHLQHERGQPP-LSWQLRLAIACQTANAIAHLHSSVNPPIYHRDIKSSNILLDHEFNSKISDFGLSRLGMSTDFEASHISTAPQGTPGYLDPQYHQDFQLSDKSDVYSFGVVLVEIISGFKVIDFTRPYSEVNLASLAVDRIGRGRVVDIIDPCLNKEINPKMFASIHNLAELAFRCLSFHRNMRPTMVEITEDLHRIKLMHYGTESGK 604          

Query:  976 STYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSREL-LLVYEYIPNGTVADHLHGKRVESGF-LSWPVRLSIAIETADALAFLH---RNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFP-----NDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQN-HLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQN 1869
            ST    ++F+  E+ +AT NF+    +G GGFG V+   L+DG + A+KR   NN K  +Q +NEV IL ++ HR+LV+L GC      EL LL+YE+IPNGT+ +HLHG    +   L+W  RL IA +TA+ LA+LH   +  + HRDVK++NIL+D     KV+DFGLSRL       N+ +H+ T  QGT GY+DPEYY+ +QLTDKSDVYSFGVVL+E+++S +A+D  R   D+NL  M INK+ +   + E +DPLL+   N +  +    +  LA  CL + R  RP+M EV D +  I N
Sbjct:  343 STGKSSRIFTGREITKATNNFSKDNLIGTGGFGEVFKAVLEDGTITAIKRAKLNNTKGTDQILNEVRILCQVNHRSLVRLLGCCV--DLELPLLIYEFIPNGTLFEHLHGSSDRTWKPLTWRRRLQIAYQTAEGLAYLHSAAQPPIYHRDVKSSNILLDEKLNAKVSDFGLSRLVDLTETANNESHIFTGAQGTLGYLDPEYYRNFQLTDKSDVYSFGVVLLEMVTSKKAIDFTREEEDVNLV-MYINKMMDQERLTECIDPLLKKTANKIDMQTIQQLGNLASACLNERRQNRPSMKEVADEIEYIIN 648          

Query:  997 VFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRN---DVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEV---LDGLR----------AIQNEDLGSEDGQAVVLDI 1914
            VFS  ELE+ATENF+  + LG GG GTVY G L DGR+VAVK+    +  ++E+F+NEV IL+++ HRN+VKL GC    ++  +LVYE+IPNG + +HLH +  E+   +W +RL IAI+ A AL++LH +    + HRDVK+ NI++D  +  KV+DFG SR    D TH++T   GT GY+DPEY+Q  Q TDKSDVYSFGVVL+ELI+  +++   R + +  LA   I  ++ + + +++D  +    +  +    TA A++A +CL  +   RP+M EV   LD +R           +   + G E  + +V DI
Sbjct:  434 VFSSRELEKATENFSSNRILGQGGQGTVYKGMLVDGRIVAVKKSKVVDEDKLEEFINEVVILSQINHRNIVKLLGCCLE-TKVPVLVYEFIPNGNLFEHLHDEFDENIMATWNIRLRIAIDIAGALSYLHSSASSPIYHRDVKSTNIMLDEKYRAKVSDFGTSRTVTVDHTHLTTVVSGTVGYMDPEYFQSSQFTDKSDVYSFGVVLVELITGEKSISFLRSQENRTLATYFILAMKENKLFDIIDARIR---DGCMLSQVTATAKVARKCLNLKGRKRPSMREVSMELDSIRMPCGDMQLQECVSENEEGEEQNKGLVEDI 751          

Query:  994 QVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFL--SWPVR--LSIAIETADALAFLHRND---VIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTM 1833
            ++F+  E+ +AT+NF  +  LG GGFG V+ G L DG  VAVKR    N K + Q +NEV+IL ++ H+NLVKL GC       +L VYE++PNGT+ +H++G     G L    P+R  L IA +TA  L +LH +    + HRDVK++NIL+D +  VKVADFGLSRL  +DV+HV+T  QGT GY+DPEYY  +QLTDKSDVYSFGVVL EL++  +A+D NR   D+NL       ++   + +++DP++             A+  LA  C+++ R  RPTM
Sbjct:  340 RIFTGKEIVKATDNFAKSNLLGFGGFGEVFKGNLDDGTTVAVKRAKLGNEKSIYQIVNEVQILCQVSHKNLVKLLGCCIELEMPVL-VYEFVPNGTLFEHIYGGGGGGGGLYDHLPLRRRLMIAHQTAQGLDYLHSSSSPPIYHRDVKSSNILLDENLDVKVADFGLSRLGVSDVSHVTTCAQGTLGYLDPEYYLNFQLTDKSDVYSFGVVLFELLTCKKAIDFNREEEDVNLVVFVRKALKEGRLMDVIDPVIGIGATEKEIESMKALGVLAELCVKETRQCRPTM 625          

Query:  970 KGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHR---NDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQN--EDL----GSEDGQAVVLDIGADD 1926
            +G      ++FS  ELE+AT+NFN  + LG GG GTVY G L DGR+VAVKR    +  +VE+F+NEV +L+++ HRN+VKL GC    +   +LVYE+IPNG +   LH    +   ++W VRL I++E A ALA+LH      V HRDVKT NIL+D  +  KV+DFG SR    D TH++T   GT GY+DPEY+Q  Q TDKSDVYSFGVVL+ELI+  +     R   +  L +     ++ + V ++VD  ++            AVA+LA RCL  +   RP M EV   L  I++  EDL      ED +   ++I  DD
Sbjct:  399 RGGNVQSSKIFSSKELEKATDNFNMNRVLGQGGQGTVYKGMLVDGRIVAVKRSKVLDEDKVEEFINEVGVLSQINHRNIVKLMGCCLE-TEVPILVYEHIPNGDLFKRLHHDS-DDYTMTWDVRLRISVEIAGALAYLHSAASTPVYHRDVKTTNILLDEKYRAKVSDFGTSRSINVDQTHLTTLVAGTFGYLDPEYFQTSQFTDKSDVYSFGVVLVELITGEKPFSVMRPEENRGLVSHFNEAMKQNRVLDIVDSRIK---EGCTLEQVLAVAKLARRCLSLKGKKRPNMREVSVELERIRSSPEDLELHIEEEDEEECAMEINMDD 721          

Query:  994 QVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRN---DVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQN---------EDLGSEDGQAVVL------DIGADDVGLLRNMPPPLS 1962
            ++FS  ELE+AT+NFN  + LG GG GTVY G L DGR+VAVKR    +  RVE+F+NEV +L ++ HRN+VKL GC    +   +LVYE++PNG +   LH +  +   ++W VRL IAIE A AL++LH      + HRD+KT NIL+D     KV+DFG SR    D TH++T   GT GYVDPEY+Q  + T+KSDVYSFGVVL+EL++  +     R   +  LA   +  ++ + V ++VD  ++ E N        +VA LA RCL ++   RP M EV   L  I++         ED   ED QA+ L      ++GA     + N   P S
Sbjct:  402 RIFSSHELEKATDNFNKNRVLGQGGQGTVYKGMLVDGRIVAVKRSKAVDEDRVEEFINEVVVLAQINHRNIVKLLGCCLE-TEVPVLVYEFVPNGDLCKRLHDES-DDYTMTWEVRLHIAIEIAGALSYLHSAASFPIYHRDIKTTNILLDERNRAKVSDFGTSRSVTIDQTHLTTQVAGTFGYVDPEYFQSSKFTEKSDVYSFGVVLVELLTGEKPSSRVRSEENRGLAAHFVEAVKENRVLDIVDDRIKDECN---MDQVMSVANLARRCLNRKGKKRPNMREVSIELEMIRSSHYDSGIHIEDDDEEDDQAMELNFNDTWEVGATAPASMFNNASPTS 737          

Query:  994 QVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRN---DVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQ--------------NEDLGSEDGQAVVLDIGAD-DVGL 1935
            ++FS  ELE+AT+NFN  + LG GG GTVY G L DGR+VAVKR    +  +VE+F+NEV +L ++ HRN+VKL GC    +   +LVYE++PNG +   L  +  +   ++W VRL IAIE A AL++LH      + HRD+KT NIL+D  + VKV+DFG SR    D TH++T   GT GYVDPEY+Q  + TDKSDVYSFGVVL+ELI+        +   +   A   +  ++ +   ++VD  ++ E N        AVA+LA RCL ++   RP M EV   L  I+              ++D   ED QA+ L+I    DVG+
Sbjct:  410 KIFSSNELEKATDNFNTNRVLGQGGQGTVYKGMLVDGRIVAVKRSKAMDEDKVEEFINEVVVLAQINHRNIVKLLGCCLE-TEVPVLVYEFVPNGDLCKRLRDE-CDDYIMTWEVRLHIAIEIAGALSYLHSAASFPIYHRDIKTTNILLDEKYQVKVSDFGTSRSVTIDQTHLTTQVAGTFGYVDPEYFQSSKFTDKSDVYSFGVVLVELITGKNPSSRVQSEENRGFAAHFVAAVKENRFLDIVDERIKDECN---LDQVMAVAKLAKRCLNRKGKKRPNMREVSVELERIRSSSYKSEIHNDDDDDDDDDDEDDQAMELNIEETWDVGM 736          

Query:  994 QVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRN---DVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSE 1887
            +VFS  +LE AT+ FN ++ LG GG GTVY G L+DG +VAVK+      + +E+F+NE+ +L+++ HRN+VK+ GC    +   +LVYE+IPN  + DHLH    E   +SW VRL IA E ADAL++LH      + HRDVK+ NIL+D     KV+DFG+SR    D TH++T  QGT GYVDPEY Q    T KSDVYSFGV+LIEL++  + V   R +    L    +  ++N  ++E++D  ++ E +   R    AVA+LA RCL    + RPTM +V   L  +Q++  G++
Sbjct:  376 KVFSSNDLENATDRFNASRILGQGGQGTVYKGMLEDGMIVAVKKSKALKEENLEEFINEIILLSQINHRNVVKILGCCLE-TEVPILVYEFIPNRNLFDHLHNPS-EDFPMSWEVRLCIACEVADALSYLHSAVSIPIYHRDVKSTNILLDEKHRAKVSDFGISRSVAIDDTHLTTIVQGTIGYVDPEYLQSNHFTGKSDVYSFGVLLIELLTGEKPVSLLRRQEVRMLGAYFLEAMRNDRLHEILDARIKEECD---REEVLAVAKLARRCLSLNSEHRPTMRDVFIELDRMQSKRKGTQ 671          

Query:   94 CSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHIN-CVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNW--FHCNNSLAFQDSYYLLGPVPLDPIMS--------TFKCEIGITVPILKTTAAKLVANRSL--FQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRVCDP------------------AGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIP-TPLTSKSVATPSTNLSQSQS-----IPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNED-----LGSEDGQAVVLDI---GADDVGLLRN-MPPPLSPDSAGTDKLVSSSTPPSS 2016
            C+  F CG  R L YPF    R   CG P+F ++ C     EL+ISS+ +R+L        ++L RS+     C     N+        +  + ++ ++IFY C+      +++N+  F C +      SYY+   +   P+          +  C+  +++P   +T   L +  S    ++A+  GF +      +  C  C+   G CG+   SS  VC        P                  AG+AV                  +           SK +P T  +S+  +   T+ + S S     +PS  +  ++SDY       GVQVFSY ELEEATENF+  +ELGDGGFGTVYYG L+DGR VAVKRLYE + KRVEQF NE+EIL  L+H NLV LYGCTSR SRELLLVYEYI NGT+A+HLHG R E+  L W  RL+IAIETA AL+FLH   +IHRD+KT NIL+D+++ VKVADFGLSRLFP D TH+STAPQGTPGYVDPEYYQCYQL +KSDVYSFGVVL ELISS +AVD  RHRHDINLANMA++KIQN+ ++ELVD  L ++ +  VRR   AVAELAFRCLQQERD+RP MDE+++ LR I++++     + S D    V+DI   G DDVGLLRN +PPP+SP+   TDK  SSS   +S
Sbjct:  631 CNGTFSCGDQRELFYPFWTSGRED-CGHPDFKLDDCSGRFAELSISSVKFRILASVYGSNIIRLGRSEYIGDLCPQDPINAPFSESVLPFAPNTEL-LTIFYNCSRDFPQ-QVTNFGDFACGDDSDDDRSYYVTRNLSFPPLSEINDLLYDFSQSCDRNVSIPASGSTLNILQSTPSNDNLKKALEYGFELEL----NQDCRTCIDSKGACGYSQTSSRFVCYSIEEPQTPTPPNPTRNKDTSLSIGAKAGIAVASVSGLAILLLAGLFLCIRRRRKTQDAQYTSKSLPITSYSSRDTSRNPTSTTISSSSNHSLLPSISNLANRSDY------CGVQVFSYEELEEATENFS--RELGDGGFGTVYYGVLKDGRAVAVKRLYERSLKRVEQFKNEIEILKSLKHPNLVILYGCTSRHSRELLLVYEYISNGTLAEHLHGNRAEARPLCWSTRLNIAIETASALSFLHIKGIIHRDIKTTNILLDDNYQVKVADFGLSRLFPMDQTHISTAPQGTPGYVDPEYYQCYQLNEKSDVYSFGVVLTELISSKEAVDITRHRHDINLANMAVSKIQNNALHELVDSSLGYDNDPEVRRKMMAVAELAFRCLQQERDVRPAMDEIVEILRGIKDDEKKRVLVKSPD----VVDIECGGGDDVGLLRNSVPPPISPE---TDKWTSSSDTAAS 1295          

Query:  109 DCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFD 696
            +CG +    +PF GG+R  +CG P   ++C  +   L ISS  + VL L+   + LKLAR+DL  S C       T+ P  F  + +    +++FY C   + T  +S++        F    +    +  D    TF     + VP  +  A +   N +  +  +++GF V      D  C +CL  +G CGF+
Sbjct:   25 ECGNI-TAGFPFWGGNRLKHCGLPSLELHCSKNITSLFISSQEFYVLHLNQTSKTLKLARTDLLGSICNSTFTTITLPPNIFELSPTYK-RLTVFYYC--FLLTHYVSSYKCPMRGFIFVSENHEYHKICGD----TFT----VIVP-TRFGAGEKELNMTNLESVLSKGFEVK-VKIDDTSCQECLSSHGSCGFN 206          

Query:  106 FDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMST---FKCEIGITVPILKT-TAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDS 705
            F CG +    +PF+GG+R   CG P   ++C N+   + IS   Y VL +D     L+LAR++L  S C      +T+  + F  +                 T   L+ ++ C+  ++++ SY   G   +    ++     C+   T+ + K+    +   + +  + A+ EGF V      +  C +C    G CGF + +
Sbjct:  416 FQCGNI-TAGFPFSGGNRPQICGHPSLELHCYNNMASIIISDHFYNVLHIDQTSNTLRLARAELEGSFCNATYTATTLPSKIFEISS----------------TYKSLTVFYLCDPKVSYRSSYTCPGRGLVSVSQNSDYHNSCQDSFTINVPKSFVPEEKELDVTNLESALREGFEVK-VKVDEKTCQKCTSSGGTCGFQNST 601          

Query:  112 CGPLRNLSYPFTG-GSRSAYCGPPEFHINC-VNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSI-FYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLD---PIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSD 702
            C PL   + P    G R  +CG P   + C  N S  L IS   + VL +D    +L LAR DL  S C+    N+T+ PE F   E    Y S+ FY C   +  P LSN+           +  ++GP+ +        T        VP    T  K + N +  +  + +GF VN  N     C  C   N  CGFD +
Sbjct:  215 CSPLNPTTQPPPQPGDRHKHCGHPLLELRCDQNKSTSLFISDQEFFVLHVDQTSYSLTLARPDLLHSFCSLTFTNTTLPPEIF---ELSPAYKSVTFYHCYPVL--PDLSNY-----------TCPVIGPISVSGNPEDHETCFPNFAANVPTSFVTKEKKL-NIANLESVLEKGFEVN-MNVIMKACQACSYSNESCGFDEN 399          

Query:   94 CSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVN--DSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEI-GITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRV----CDP---------AGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFT-----------SKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDI-GADDVGLLRN-MPPPLSPDSAGTDKLV--SSSTPPSSF 2019
            C  +F CG L    +PF G +R   CG P   ++C    +S  L ISSL YRVL+++     LKL R D     C+     +T+ PE F     D   +S +Y CN ++  P     F C N          +G +  D +       I  ITVPI      +   N +  +  + +GF V  +   +  C +C    G+C +    + PVC   N      C P         AGL+                              + K++ T  T+K ++T +T  S + ++ + P+ T           S S+   GS Y G+QVFSY ELEEATENF+  KELGDGGFGTVYYG L+DGR VAVKRL+E + KRVEQF NE++IL  L+H NLV LYGCT+R SRELLLVYEYI NGT+A+HLHG + +S  + WP RL IAIETA AL++LH + +IHRDVKT NIL+D+++ VKVADFGLSRLFP D TH+STAPQGTPGYVDPEYYQCY+L +KSDVYSFGVVL ELISS +AVD  RHRHDINLANMAI+KIQN  V+EL D  L F  +  V++M ++VAELAFRCLQQERD+RP+MDE+++ LR IQ + +       V +D+ G DDVGLL++ +PPPLSP+   TDK    SS+T  SSF
Sbjct:   38 CDTLFRCGDL-TAGFPFWGVARPQPCGHPSLGLHCQKQTNSTSLIISSLMYRVLEVNTTTSTLKLVRQDFSGPFCSASFSGATLTPELFELLP-DYKTLSAYYLCNPSLHYPAK---FICPNKG--------VGSIHQDDLYHNHCGGIFNITVPI-GYAPEEGALNVTNLESVLKKGFEVKLSID-ERPCQECKTNGGICAYHV--ATPVCCKTNSSSEVNCTPMMPSGSSAHAGLSKKGKIGIGFASGFLGATLI-GGCLLCIFIRRRKKLATQYTNKGLST-TTPYSSNYTMSNTPTSTTISGSNHSLVPSISNLGNGSVYSGIQVFSYEELEEATENFS--KELGDGGFGTVYYGTLKDGRAVAVKRLFERSLKRVEQFKNEIDILKSLKHPNLVILYGCTTRHSRELLLVYEYISNGTLAEHLHGNQAQSRPICWPARLQIAIETASALSYLHASGIIHRDVKTTNILLDSNYQVKVADFGLSRLFPMDQTHISTAPQGTPGYVDPEYYQCYRLNEKSDVYSFGVVLSELISSKEAVDITRHRHDINLANMAISKIQNDAVHELADLSLGFARDPSVKKMMSSVAELAFRCLQQERDVRPSMDEIVEVLRVIQKDGISDSKDVVVEIDVNGGDDVGLLKHGVPPPLSPE---TDKTTASSSNTTASSF 686          

Query:  112 CGPLRNLSYPF-TGGSRSAYCGPPEFHINCVNDS--PELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPL--DPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCIC--GNRVCDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQS-QSIPSYPSFTSKSDYDKGSTYF-GVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSE 1887
            CG    +SYPF   G + ++CG P F + C ++   P L IS   Y +  +  + ++ ++  S      C   + N T+    F  N S  I  +I Y C+  +     +    C  + +   S+ +     L  +  +++  C+  + VP+L +  + ++     + E +  GF +N+T    N C +C+   G CG  +D  E VC+C  G ++ D                                       +     +KS    S  L ++  S PS  SF    D +K      GV +FSY ELEEAT NF+P+KELGDGGFGTVYYGKL+DGR VAVKRLY+NNFKR EQF NEVEILT L H NLV L+GC+S++SR+LLLVYEY+ NGT+ADHLHG +     L W +RL IA+ETA AL +LH + +IHRDVK+NNIL+D +F VKVADFGLSRLFP D THVSTAPQGTPGYVDP+Y+ CYQL++KSDVYSF VVL+ELISSL AVD  R R +INL+NMA+ KIQNH + ++VDP L F+T+  VR+   AVAELAF+CLQ ++D+RP M  V D L  IQN   GSE
Sbjct:   39 CGKGPQISYPFYLSGKQESFCGYPSFELTCDDEEKLPVLGISGEEYVIKNISYLTQSFQVVNSKASHDPCPRPLNNLTLHRTPFFVNPSH-INFTILYNCSDHLLEDFRTYPLTCARNTSLLRSFGVFDRKKLGKEKQIASMSCQKLVDVPVLASNESDVMG--MTYVEILKRGFVLNWTA---NSCFRCITSGGRCG--TDQQEFVCLCPDGPKLHDTCTNGKNDKRRRVIVKITKSISGASAAVVGLIAASIFWYVYHRRKTKSYRNSSALLPRNISSDPSAKSF----DIEKAEELLVGVHIFSYEELEEATNNFDPSKELGDGGFGTVYYGKLKDGRSVAVKRLYDNNFKRAEQFRNEVEILTGLRHPNLVALFGCSSKQSRDLLLVYEYVANGTLADHLHGPQANPSSLPWSIRLKIAVETASALKYLHASKIIHRDVKSNNILLDQNFNVKVADFGLSRLFPMDKTHVSTAPQGTPGYVDPDYHLCYQLSNKSDVYSFAVVLMELISSLPAVDITRPRQEINLSNMAVVKIQNHELRDMVDPSLGFDTDTRVRQTVIAVAELAFQCLQSDKDLRPCMSHVQDTLTRIQNNGFGSE 627          

Query:   52 EVTTSFPSNANLSNC-SRVFDCGP----LRNLSYPFTGG-SRSAYCGPPEFHINCVNDSP-ELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRV----CDP---AGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYF-GVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSE 1887
            ++ + F ++     C SR   CG       + +YPF GG ++  +CG   F ++C  D    L I +++ RV+  +     + +A   L    C + ++N   K +F   + ++ I   +F  C S +   ++S    C  S     +Y++L     D       C     +P+L++   +L  +   F EA+ +GF + Y    D  C +C+   G+CG   DS    C+C +R     CD     G                                  +       + S   P  N+S   S  S+       D +K      GV +FSY ELEEAT NF+P+KELGDGGFGTVYYGKL+DGR VAVKRLY+NNFKR EQF NEVEILT L H NLV L+GC+S++SR+LLLVYEY+ NGT+ADHLHG +     L W +RL IA+ETA AL +LH + +IHRDVK+NNIL+D +F VKVADFGLSRLFP D THVSTAPQGTPGYVDP+Y+ CYQL++KSDVYSF VVL+ELISSL AVD  R R +INL+NMA+ KIQNH + ++VDP L F+T+  VR+   AVAELAF+CLQ ++D+RP M  V D L  IQN   GSE
Sbjct:   17 DLPSCFSADQQYEECRSRNLTCGSGHRVFESTTYPFWGGFNKPKFCGHSSFKLSCEGDQNLTLAIGNITLRVVSANLEDHKISVADDSLLDGGCLN-IWNFNGKNQFTLDSNTETI--DVFVNC-SGVAPLQIS----CEESYEDPVTYHVLRSSDSDE-----GCMKYAEIPMLRSAKDELQRSELTFVEALRKGFDLRYIME-DKACRRCIDSGGICGSALDSESFRCLCADRPHNSSCDDNTNQGKNDKRRRVIVKVLIGASAAVVGLIAASIFWYVYHRRKTKSYRNSSALLPR-NISSDPSAKSF-------DIEKAEELLVGVHIFSYEELEEATNNFDPSKELGDGGFGTVYYGKLKDGRSVAVKRLYDNNFKRAEQFRNEVEILTGLRHPNLVALFGCSSKQSRDLLLVYEYVANGTLADHLHGPQANPSSLPWSIRLKIAVETASALKYLHASKIIHRDVKSNNILLDQNFNVKVADFGLSRLFPMDKTHVSTAPQGTPGYVDPDYHLCYQLSNKSDVYSFAVVLMELISSLPAVDITRPRQEINLSNMAVVKIQNHELRDMVDPSLGFDTDTRVRQTVIAVAELAFQCLQSDKDLRPCMSHVQDTLTRIQNNGFGSE 621          

Query:  952 SKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRV-ESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSED----GQAVVLDIGADDVG---LLRNMPPPLSPDSAGTDKLVSSSTPPSS 2016
            SKSD +    +F + +FSY EL+ AT+NF+  + LGDGGFGTVYYGK++DGR VAVKRLYE+N++R+EQFMNE+EILTRL H+NLV LYGCTSRRSRELLLVYE+IPNGTVADHL+G+     GFL+W +RLSIAIETA ALA+LH +D+IHRDVKT NIL+D +F VKVADFGLSRL P+DVTHVSTAPQGTPGYVDPEY++CY LTDKSDVYSFGVVL+ELISS  AVD +R + +INL+++AINKIQNH  +EL+D  L + TN  VR+M T VAELAF+CLQQ+  MRPTM++V+  L+ IQNE+          + ++      D G   LL+NM  P SP S  TD+  S ST P++
Sbjct:  263 SKSDVEFSQVFFKIPIFSYKELQAATDNFSKDRLLGDGGFGTVYYGKVRDGREVAVKRLYEHNYRRLEQFMNEIEILTRLHHKNLVSLYGCTSRRSRELLLVYEFIPNGTVADHLYGENTPHQGFLTWSMRLSIAIETASALAYLHASDIIHRDVKTTNILLDRNFGVKVADFGLSRLLPSDVTHVSTAPQGTPGYVDPEYHRCYHLTDKSDVYSFGVVLVELISSKPAVDISRCKSEINLSSLAINKIQNHATHELIDQNLGYATNEGVRKMTTMVAELAFQCLQQDNTMRPTMEQVVHELKGIQNEEQKCPTYDYREETIIPHPSPPDWGEAALLKNMKFPRSPVSV-TDQWTSKSTTPNT 624          

Query:  922 QSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRN---DVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQ------NEDLGSEDGQAVVLDIGAD------DVGLLRNMPPPLSPDSAGTDKLVSSSTPPS 2013
            +S P     ++K    + +    V  F Y E+E+AT+ F+  ++LG G +GTVY GKLQ+   VA+KRL   + + ++Q MNE+++L+ + H NLV+L GC   +  + +LVYEY+PNGT+++HL  +R     L W +RL++A +TA A+A+LH +    + HRD+K+ NIL+D DF  KVADFGLSRL   + +H+STAPQGTPGY+DP+Y+QC+ L+DKSDVYSFGVVL E+I+ L+ VD  R   +INLA +A++KI +  ++E++DP+L+ + +         VAELAFRCL    DMRPTM EV D L  I+      +  L S  G     D G++       +G  R + P   PD   + + +S S+P S
Sbjct:  310 RSTPLRSHLSAKRLLSEAAGNSSVAFFPYKEIEKATDGFSEKQKLGIGAYGTVYRGKLQNDEWVAIKRLRHRDSESLDQVMNEIKLLSSVSHPNLVRLLGCCIEQG-DPVLVYEYMPNGTLSEHL--QRDRGSGLPWTLRLTVATQTAKAIAYLHSSMNPPIYHRDIKSTNILLDYDFNSKVADFGLSRLGMTESSHISTAPQGTPGYLDPQYHQCFHLSDKSDVYSFGVVLAEIITGLKVVDFTRPHTEINLAALAVDKIGSGCIDEIIDPILDLDLDAWTLSSIHTVAELAFRCLAFHSDMRPTMTEVADELEQIRLSGWIPSMSLDSPAGSLRSSDRGSERSVKQSSIGSRRVVIPQKQPDCLASVEEISDSSPIS 685          

Query:  922 QSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRN---DVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQ------NEDLGSEDGQAVVLDIGAD------DVGLLRNMPPPLSPDSAGTDKLVSSSTPPS 2013
            +S P     ++K    + +    V  F Y E+E+AT+ F+  ++LG G +GTVY GKLQ+   VA+KRL   + + ++Q MNE+++L+ + H NLV+L GC   +  + +LVYEY+PNGT+++HL  +R     L W +RL++A +TA A+A+LH +    + HRD+K+ NIL+D DF  KVADFGLSRL   + +H+STAPQGTPGY+DP+Y+QC+ L+DKSDVYSFGVVL E+I+ L+ VD  R   +INLA +A++KI +  ++E++DP+L+ + +         VAELAFRCL    DMRPTM EV D L  I+      +  L S  G     D G++       +G  R + P   PD   + + +S S+P S
Sbjct:  310 RSTPLRSHLSAKRLLSEAAGNSSVAFFPYKEIEKATDGFSEKQKLGIGAYGTVYRGKLQNDEWVAIKRLRHRDSESLDQVMNEIKLLSSVSHPNLVRLLGCCIEQG-DPVLVYEYMPNGTLSEHL--QRDRGSGLPWTLRLTVATQTAKAIAYLHSSMNPPIYHRDIKSTNILLDYDFNSKVADFGLSRLGMTESSHISTAPQGTPGYLDPQYHQCFHLSDKSDVYSFGVVLAEIITGLKVVDFTRPHTEINLAALAVDKIGSGCIDEIIDPILDLDLDAWTLSSIHTVAELAFRCLAFHSDMRPTMTEVADELEQIRLSGWIPSMSLDSPAGSLRSSDRGSERSVKQSSIGSRRVVIPQKQPDCLASVEEISDSSPIS 685          

Query:  991 VQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRN---DVIHRDVKTNNILIDNDFCVKVADFGLSRLFPN---DVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQ 1896
            V  ++Y E+E+AT++F+    LG G +GTVY G+  +   VA+KRL   +   ++Q +NE+++L+ + H NLV+L GC      E  LVYE++PNGT+  HL  +R +   LSW +RL+IA +TA+A+A LH +    + HRD+K++NIL+D++F  K++DFGLSRL  +   + +H+STAPQGTPGY+DP+Y+Q +QL+DKSDVYSFGVVL+E+IS  + +D  R   ++NLA++A+++I    V +++DP L  E N  +      +AELAFRCL   R+MRPTM E+ + L  I+    G+E G+
Sbjct:  299 VPFYTYKEIEKATDSFSDKNMLGTGAYGTVYAGEFPNSSCVAIKRLKHKDTTSIDQVVNEIKLLSSVSHPNLVRLLGCCFADG-EPFLVYEFMPNGTLYQHLQHERGQPP-LSWQLRLAIACQTANAIAHLHSSVNPPIYHRDIKSSNILLDHEFNSKISDFGLSRLGMSTDFEASHISTAPQGTPGYLDPQYHQDFQLSDKSDVYSFGVVLVEIISGFKVIDFTRPYSEVNLASLAVDRIGRGRVVDIIDPCLNKEINPKMFASIHNLAELAFRCLSFHRNMRPTMVEITEDLHRIKLMHYGTESGK 604          

Query:  997 VFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKR-----------VEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRN---DVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVT---------HVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRM----ATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQA 1899
            VF++ ELE AT  F+P +++GDGGFG+VY G+L DG+++AVK L+ ++              ++ F NE+ IL+ + H NLVKL+G  S   R LLLV++Y+ NGT+ADHLHG+  +   ++W VRL IA++TA A+ +LH +    V+HRD+ ++NI ++ D  +KV DFGLSRL     T         +V T PQGTPGY+DP+Y++ ++LT+KSDVYS+GVVL+ELI+ ++AVD  R + D+ LA++ ++KIQ  L+++++DPLL  + + V          AVAELAFRC+  ++D RP   E++  LR I++    ++D  A
Sbjct:  311 VFTFEELESATNKFDPKRKIGDGGFGSVYLGQLSDGQLLAVKFLHHHHGATAAATEHCKAFSMKSFCNEILILSSINHPNLVKLHGYCSD-PRGLLLVHDYVTNGTLADHLHGRGPK---MTWRVRLDIALQTALAMEYLHFDIVPPVVHRDITSSNIFVEKDMKIKVGDFGLSRLLVFSETTVNSATSSDYVCTGPQGTPGYLDPDYHRSFRLTEKSDVYSYGVVLMELITGMKAVDQRREKRDMALADLVVSKIQMGLLDQVIDPLLALDGDDVAAVSDGFGVAAVAELAFRCVATDKDDRPDAKEIVQELRRIRSHTRVADDDVA 634          

Query:  976 STYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSREL-LLVYEYIPNGTVADHLHGKRVESGF-LSWPVRLSIAIETADALAFLH---RNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFP-----NDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQN-HLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQN 1869
            ST    ++F+  E+ +AT NF+    +G GGFG V+   L+DG + A+KR   NN K  +Q +NEV IL ++ HR+LV+L GC      EL LL+YE+IPNGT+ +HLHG    +   L+W  RL IA +TA+ LA+LH   +  + HRDVK++NIL+D     KV+DFGLSRL       N+ +H+ T  QGT GY+DPEYY+ +QLTDKSDVYSFGVVL+E+++S +A+D  R   D+NL  M INK+ +   + E +DPLL+   N +  +    +  LA  CL + R  RP+M EV D +  I N
Sbjct:  343 STGKSSRIFTGREITKATNNFSKDNLIGTGGFGEVFKAVLEDGTITAIKRAKLNNTKGTDQILNEVRILCQVNHRSLVRLLGCCV--DLELPLLIYEFIPNGTLFEHLHGSSDRTWKPLTWRRRLQIAYQTAEGLAYLHSAAQPPIYHRDVKSSNILLDEKLNAKVSDFGLSRLVDLTETANNESHIFTGAQGTLGYLDPEYYRNFQLTDKSDVYSFGVVLLEMVTSKKAIDFTREEEDVNLV-MYINKMMDQERLTECIDPLLKKTANKIDMQTIQQLGNLASACLNERRQNRPSMKEVADEIEYIIN 648          

Query:   46 SFEVTTSFPSN--ANLSNCSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPE-LTISSLSYRVLQLDPVRRNLKLARSDLWTS-TCTDKVFNSTMKPEFFAYNESDDIYVSIFYGC---NSTIT----TPKLSNWFHCNNSLAFQDSYY-LLGPVPLD-PIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVN--GLCGFDSDSSEPVCICGNRVCDPA---------GLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIP--TPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDY-DKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPP--LSPDSAGTDKLVSSST 2004
            S  +TTS PSN  +NLSNC++ F CG L N++YPFTGG R ++CGPPEF + C ++S   L  +SLSYRV  LD   + L+L+RSDL+    CT +  N+T+    F+   S ++Y  +FYGC   N ++      PK+S  F C+     ++ ++ ++ P   +    +TF+C+  I VPI  T A +L  N S+  E + EGF V+Y+NPY   C +C   +  G CGFD+   +P+CIC +++C            GL+                   Q          +SK +P  TP +SK + T STNLSQ+ +     S TS   Y +KGSTYFGV VFSY+ELEEAT  F+P+KELGDGGFGTVY+G L+DGRVVAVKRLYENN +R EQFMNE+EIL  L H+NLV LYGCT+R S ELLLVYEYIPNGTVADHLHG++  SG L+WPVRLSIAIETA ALA+LH +DVIHRDVKT NIL+DNDF VKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLT+KSDVYSFGVVLIELISSLQAVDTNRHRHDINL+NMA+NKIQNH +NELVDP L F+ + VVRRM T+VAELAFRCLQQ+R+MRP M+EVL+ L+ I+ E+ G+  G A VLDI  DDVGLL++ PPP  LSPDS        SS+
Sbjct:   18 SLHLTTSLPSNDISNLSNCNQNFSCGDLTNVTYPFTGGLRPSHCGPPEFGLTCEDESVTILKANSLSYRVTHLDQTSQTLRLSRSDLYDDGKCTRQFTNTTLDDRIFSLGSSHELY--LFYGCKKINDSVMGSDQLPKISR-FSCDYHGVTEEGFFSIVYPYGTEYSFPNTFECQTTIRVPIPSTRAQQLFDNESVVGEVLKEGFDVSYSNPYSANCTECYKEHPGGYCGFDTQLGKPICICNDKLCPEKKTKDRTLVIGLSTAGAVVIGIFFGCWVLFVVQRRKRKSAQV-KSKGLPVATPPSSKGLTT-STNLSQATT-----SLTSSKSYLEKGSTYFGVPVFSYSELEEATNCFDPSKELGDGGFGTVYHGVLKDGRVVAVKRLYENNMRRAEQFMNEIEILAHLRHKNLVILYGCTTRHSHELLLVYEYIPNGTVADHLHGRQSNSGLLTWPVRLSIAIETASALAYLHTSDVIHRDVKTTNILLDNDFHVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTNKSDVYSFGVVLIELISSLQAVDTNRHRHDINLSNMAVNKIQNHALNELVDPFLGFDKDIVVRRMVTSVAELAFRCLQQDREMRPAMEEVLEALKRIEKENYGA--GNAEVLDIRDDDVGLLKHAPPPVQLSPDSLSDPFWADSSS 687          

Query:   94 CSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTI-TTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPIL-KTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRV----CDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLT--SKSVATPSTNLSQSQSIPSYPSFT-SKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPP--LSPDS 1971
            C  +FDCG ++ + YPF+G +R  YCG P F +NC N  PE+TI+  +Y+VL ++   R L +AR+D   + C   + N+T+ P    Y  +DD  ++I+YGC +   +T  L   F C+ +      Y+       D      +       PI+   T AKL+        A+N+GF + + N  D  C  C    G CG+D  +    C C +R     C P+   +                             +SK++P   T  SK +AT STNLSQ+      PS T SKSD DKGSTYFGV+VFSY ELEEAT  F+ +KELGDGGFGTVYYG L+DGRVVAVKRLYE+N +R EQFMNE+EIL  L H+NLV+LYGCTSR SRELLLVYEY+PNGTVADHLHG++  SG L+WPVRLSIAIETA ALA+LH +DVIHRDVKTNNIL+DNDF VKVADFGLSRLFP DVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELIS+L+AVDTNRHRHDINL+ MA+ KIQN  +NELVDP L F+ + VVR+M T+VAELAFRCLQQ+R+MRPTM+EVL+ LR I+ E+ G+E  +A VLDI  DDVGLL++ PPP  LSPDS
Sbjct:  308 CRNLFDCGNIKGIGYPFSGSNRPDYCGYPGFGLNCSNQVPEITITQSTYKVLAINNQSRTLNVARTDYRENLCPTLLLNTTLNPSLLNYT-TDDHNITIYYGCPAQAPSTSYLLTQFPCSINTTEMTGYF----TATDDFSFLVQVRQSALEPIIGNATEAKLLG-------ALNQGFGLVW-NANDTLCDTCNSSGGQCGYDQTTKAFACYCADRPRDFNCLPSPPRLSIAGTVVGVFLGCWIMTIIQLKRRKAALLKSKDLPIAATPSSKGLAT-STNLSQTT-----PSLTPSKSDIDKGSTYFGVRVFSYNELEEATNCFDSSKELGDGGFGTVYYGVLRDGRVVAVKRLYESNMRRAEQFMNEIEILAHLRHKNLVELYGCTSRHSRELLLVYEYMPNGTVADHLHGRQSNSGLLTWPVRLSIAIETASALAYLHASDVIHRDVKTNNILLDNDFHVKVADFGLSRLFPTDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISALEAVDTNRHRHDINLSIMAVKKIQNQALNELVDPFLGFDKDFVVRKMVTSVAELAFRCLQQQREMRPTMEEVLEILRRIEKENYGAE--KADVLDIREDDVGLLKHPPPPLQLSPDS 923          

Query:   55 VTTSFPSNANLSNCSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYV--SIFYGC-NSTITTPKLSNWFHCN-NSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNR 735
            +  S  +N   S+CS  F CG +    +PF G +R + CG PE  + C N+  ++ I+ + YRVL +      L++AR D     C  +  NST  P  F   ES   Y+  +  YGC    +  P L   F C  N + +Q  + L  P    P        +    P++   A   + +    ++ + +GF + +       C +CL   G CG+DS S+E  C   N+
Sbjct:   25 IPLSLSNNDLFSDCSNQFVCGNI-TADFPFWGSARPSSCGIPELELKCENNITKMNINEVRYRVLDIKQDTEILRIAREDSLVGLCPPQFVNSTFDPMMF---ESVTGYMNFTFVYGCLPFDLDGPAL---FTCRINGVNYQSGFVL--PKASGP--GACYSSVFFPAPVI---ALPSILDVPALKQYLKKGFEIRW-KVDSTACRECLRSAGACGYDSTSNETTCYWPNQ 240          

Query:   94 CSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNST-ITTPKLSNWFHCNNSLAFQDSYY-------LLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQ--EAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRVCD--------PAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLT--SKSVATPSTNLSQSQSIPSYPSFT-SKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPP--LSPDS 1971
            C  +FDCG ++ + YPF+G +R  YCG P F INC N  PE+TI+  +Y+VL ++   R + +AR+D   + C   + N+T+ P    Y  +DD  ++I+YGC +    T  L   F C+ +      Y+        L  +  + I     C+  + V + ++    ++ N ++ +   A+N+GF + + N  D  C  C    G CG+D  +    C C ++  D             +                             +SK++P   T   K +AT STNLSQ+      PS T SKS+ DKGSTYFGV+VFSY ELEEAT  F+ +KELGDGGFGTVYYG L+DGRVVAVKRLYE+N +R EQFMNE+EIL  L H NLV+LYGCTSR SRELLLVYEYIPNGTVADHLHG++  SG L+WP RLSIAIETA ALA+LH +DVIHRDVKTNNIL+DNDF VKVADFGLSRLFP DVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELIS+L+AVDTNRHRHDINL+ MA+NKIQNH +NELVDP L F+ + VVR+M T+VAELAFRCLQQ+R+MRPTM+EVL+ LR I+ E+ G+E  +A VLDI  DDVGLL++ PPP  LSPDS
Sbjct:   38 CRNLFDCGNIKGIGYPFSGSNRPDYCGYPGFEINCSNQIPEITITQSTYKVLAINNQSRTINVARTDYRENLCPTLLLNTTLNPSLLNYT-TDDHNITIYYGCPAQGPPTSHLLTQFPCSINTTEMTGYFTATDDFSFLANLASNLIRYLESCDNSLKVQVRQSALEPIIGNATVAKLLGALNQGFGLVW-NANDTLCDTCNSSGGQCGYDQTTKAFACYCADQPRDFNCLRSPPSQSTRLSIAGTVVGVFLGCWIMTIIQRKRRKAALLKSKDLPIAATPSGKGLAT-STNLSQTT-----PSLTPSKSEIDKGSTYFGVRVFSYNELEEATNCFDSSKELGDGGFGTVYYGVLRDGRVVAVKRLYESNMRRAEQFMNEIEILAHLRHMNLVELYGCTSRHSRELLLVYEYIPNGTVADHLHGRQSNSGLLTWPFRLSIAIETASALAYLHASDVIHRDVKTNNILLDNDFHVKVADFGLSRLFPTDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISALEAVDTNRHRHDINLSIMAVNKIQNHALNELVDPFLGFDKDFVVRKMVTSVAELAFRCLQQQREMRPTMEEVLEILRRIEKENYGAE--KADVLDIREDDVGLLKHPPPPLQLSPDS 676          

Query:   91 NCSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPL----DPIMSTF--KCEIGITVPILKTTAAKLV--ANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRVCD---------PAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKE---IPTPLTSKSVATPSTNLSQSQSIPSYPSFTS-KSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPP--LSPDSAGTDKLVSSST 2004
            NC + FDCG ++++ YPF+G  R  YCG P F + C N  PE+TI   +Y++L ++   R L ++RSD   + C   + N+++ P   + + SD   V+++YGC S  +    S  F CN +      Y++   + +    DP + ++   C   + VP L++    ++  +N S F EAIN+GF + ++   D+ C  C    G CG++  ++   C C ++  D         P+   +                             +  E   I TP +SK +AT ST LS++      PS TS KSD DKGSTYFGV+VFSY ELEEAT  F+ ++ELGDGGFGTVYYG L+DG  VAVKRLYENN KR EQFMNE+EIL  L+HRNLVKL+GCTSR SRELLLVYEYIPNGTVADHLHG++  SG L+ PVRLSIAIETA AL +LH +DVIHRDVKTNNIL+DNDFCVKVADFGLSRLFP +VTH++TAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELIS+LQAVDTNR RHDINL+NMA+NKIQNH +NELVDP L F+ + VVRRM T+VAELAFRCLQQ+R+MRPTM+EVL+ L+ I+NE+ G+E  +A VLDI  DDVGLL++   P  LS DS     L SSS+
Sbjct:   29 NCMKSFDCGDIKDVGYPFSGSDRPDYCGYPGFELGCSNQDPEITIMQSTYKLLGINNQSRTLNVSRSDYTENLCPTLLSNTSLNPNLLS-STSDHAEVTLYYGCPSP-SPAGFSAQFTCNINNTVMMGYFITVNLSVISMTDPSLISYLTTCNNSVKVPALQSAIVPILVSSNVSQFLEAINQGFELEWS-ANDSLCDTCESSGGQCGYNKTTTAFTCYCADQPQDFECSSSPQAPSQSTILSSAGAVVGAFVGCWIMAFIQRKRRKAALEKTEELPIATP-SSKGLAT-STTLSRTT-----PSLTSLKSDIDKGSTYFGVRVFSYDELEEATNFFDSSRELGDGGFGTVYYGVLRDGHEVAVKRLYENNMKRTEQFMNEIEILAHLQHRNLVKLHGCTSRHSRELLLVYEYIPNGTVADHLHGRQSSSGLLTLPVRLSIAIETASALVYLHASDVIHRDVKTNNILLDNDFCVKVADFGLSRLFPTNVTHLTTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISALQAVDTNRRRHDINLSNMAVNKIQNHALNELVDPFLGFDKDFVVRRMVTSVAELAFRCLQQQREMRPTMEEVLEILKRIENENYGAE--KADVLDISEDDVGLLKHASSPLQLSADSMSDQFLGSSSS 677          

Query:   55 VTTSFPSN--ANLSNCSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCV-NDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTST-CTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKL-VANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGL-CGFDSDSSEPVCICGNRVCD------PAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIP--TPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDG 1893
            +T SFPSN  +NLSNC++ F CG L N++YPFTGG R   CGP EF + C  N    L + SL YRV ++    + L+L+  D +    CT    ++T     F+   + +  +++FYGC +   + K      C       + ++++G  P        +C+    VP L++   +L +   SL  E + EGF V Y++PY   C +C   +G  CGFD     P+CIC +++C       P  + V                  +          QS+ +   TP +S  +AT   +++  ++ PS  +   KSD D+GSTY GV+VFSY ELEEAT  F+ +KELGDGGFGTVYYG L+DGRVVAVKRLYE+N +R EQFMNE+EIL  L H+NLV+LYGCTSR SRELLLVYEY+PNGTVADHLHG++  SG L+WPVRLSIAIETA ALA+LH +DVIHRDVKTNNIL+DNDF VKVADFGLSRLFP DVTHVSTAPQGTPGYVDPEYYQCY LT+KSDVYS+GVVLIELIS+L+AVD  RHRHDINL+NMA+NKIQNH +NELVDP L F+ + VVR M ++VAELAF CLQ ER+MRPTM+EVL+ LR I+ E+ G+  G
Sbjct:   22 LTASFPSNYMSNLSNCNQNFSCGALTNIAYPFTGGERPPLCGPREFWLTCDGNSQTTLKVKSLPYRVTRIHQTTQTLRLSPLDFYADRPCTYPSTSTTFDNGIFSLASNHET-LTLFYGCKNLSDSVKAIK-IPCPMPGDSGEGFFMIGDHP-----PMERCQTRFQVPFLRSREEELQIEGSSLLGEVLKEGFDVRYSDPYSADCQKCSKHSGRQCGFDG--KVPICICNDQLCTEKSNRKPLIIGVSLASGALVIFVGCWIMVVKQMKKRKSALVQSEGLRAVTPTSSNGLAT---SINFFRTTPSLANL--KSDLDRGSTYLGVRVFSYNELEEATNCFDSSKELGDGGFGTVYYGVLRDGRVVAVKRLYESNMRRAEQFMNEIEILAHLRHKNLVELYGCTSRHSRELLLVYEYLPNGTVADHLHGRQSNSGLLTWPVRLSIAIETASALAYLHASDVIHRDVKTNNILLDNDFHVKVADFGLSRLFPTDVTHVSTAPQGTPGYVDPEYYQCYHLTNKSDVYSYGVVLIELISALEAVDITRHRHDINLSNMAVNKIQNHALNELVDPFLGFDKDFVVREMVSSVAELAFMCLQHEREMRPTMEEVLEVLRGIERENYGAGKG 634          

Query:   64 SFPSNANLSNCSRVFDCGPLR------NLSYPF-TGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPI-----MSTFKCEIGITVPIL--KTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRV----CDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTDKLVSSSTPPSS 2016
            ++ +N  +S   +   C P        N+SYPF     + ++CG P F +NC +  P L IS+  Y +  +     +L +A + ++  TC   + N  +    F  +      +S FY C S    PK  N+ + N S A   ++Y       + I      S   C   +  PI   +   + L  N   ++E +  GF +N+T P    C+ C    G CGF++   E +C C +R     CD   + +                             + K     + S+S+          +S+PS     SK+  +  S+Y G  +FSY ELEEAT NF+  +ELGDGGFGTVYYGKL DG  VAVKRLYENNFKR+EQF+NEV+ILT L H+NLV L+GCTSR SRELLLVY+YIPNGT+ADHLHG+R + G L W  R++IA+ETA ALA+LH + ++HRDVKT+NIL+DN+FCVKVADFGLSRLFP DVTHVSTAPQGTPGYVDPEY++CYQLTDKSDVYSFGVVLIELISS+ AVD +RHRH+INL+ MAINKIQ+  +NELVDP L FE+++  R+M  AVAELAF+CLQ  +++RP+M++V   L+ IQ+ D  +E  +A  ++  +DDV LL++ P P SPD+     + +SSTP +S
Sbjct:   23 TYLANQTVSQHPKFKSCEPKNCGGAGPNISYPFWLSQEQESFCGYPNFMLNCSDKGPVLAISNDVYIIKSISYANNSLLVANAAVYEETCPTPLHNINLDRTPFTISPGYT-NLSFFYSCTSK---PKDYNYLY-NLSCATNSTHYSFAGFHFEEIEKHSNYSLKSCHDFVIAPIHTGEDNGSLLGEN---YREVLKMGFLMNWTAP---NCSTCESSGGRCGFENH--ECICFCRDRPRLKSCDAVTMLIAFFFWYR----------------------RKKRQYESIFSRSI----------KSLPS-----SKAHTEMRSSYNGAHLFSYEELEEATNNFDKTRELGDGGFGTVYYGKLPDGLEVAVKRLYENNFKRLEQFLNEVDILTPLRHQNLVLLHGCTSRDSRELLLVYQYIPNGTLADHLHGERAKPGALPWSTRMNIAVETACALAYLHASVIVHRDVKTSNILLDNNFCVKVADFGLSRLFPTDVTHVSTAPQGTPGYVDPEYHECYQLTDKSDVYSFGVVLIELISSMPAVDISRHRHEINLSTMAINKIQSDSLNELVDPSLGFESDYAARKMIRAVAELAFQCLQNAKELRPSMEKVFHILKEIQSRDYNAE--KAENINSPSDDVVLLKSGPIPPSPDTVTVTWMSTSSTPHAS 639          

Query:   55 VTTSF-PSNANLSNCSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDS-PELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKV---FNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYD---NQCAQCLGVNGLCGFDSDSSE----------PVCICGNRVCD---------PAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTDKLVSSSTPPSS 2016
            V+TS+   + + ++C + F CG L  LSYPF GG R   CG   F + C     P +   +L +R+L L    R + L   +     C  ++    +S      F Y+ S    +++ Y C+ + +     N     N       Y     +     +   +C + I +PI K+    LV +R+  +E + EGF V+Y   YD   + C  C+   G+CG +    +            C   N+  +          AG ++                             + K     + S+S+ +  ++ + ++   SY           G+  F  +     ELEEAT NF+  +ELG+GGFGTVYYGKL DG  VAVKR YENN+KR+EQF+NEV+ILTRL H+NLV L+GCTSR SRELLLVY+YIPNGT+ADHLHG+R + G L W  R++IA+ETA ALA+LH + ++HRDVKT NIL+DN+FCVKVADFGLSRLFP DVTHVSTAPQGTPGYVDPEY+QCYQLTDKSDVYSFGVVLIELISS+ AVD +RHRH+INL+ MAINKIQ++ +NELVDP L FE+++  R+M  AVAELAF+CLQ  +++RP+M+EVL  L+ IQ+ D  +E  +A  ++  +DDVG+L++ P P SPD+     + +SSTP +S
Sbjct:   25 VSTSYGDDDKDYTDCEKPFSCGLLPELSYPFWGGDRPEVCGHKAFQLRCEEGQLPIIASDTLEFRLLNLKQSSRWMALQLVNFEEYICPTQIRTNSSSGSDIHIFGYDLSLQ-NLNLLYNCSISSSEVLSKNTISFCNGYTGSSFYGNYDILVNSSGLDVMQCSMRIRIPIAKSFGELLVGDRAELEEVLGEGFNVSY--EYDQGPSICEGCMASRGICGTNMTHPDKEFMKHCNTFKSCCFRNKYPEYIYLWFPFSHAGTSLNVGRKVAIGLGASLGTLVTMLIAFFFWYRRKKRQYESIFSRSIKSVPSSKAHTEKRSSY----------NGAHLFSYE-----ELEEATNNFDKTRELGNGGFGTVYYGKLPDGLEVAVKRSYENNYKRLEQFLNEVDILTRLRHQNLVLLHGCTSRDSRELLLVYQYIPNGTLADHLHGERAKPGALPWSTRMNIAVETAYALAYLHASVIVHRDVKTTNILLDNNFCVKVADFGLSRLFPTDVTHVSTAPQGTPGYVDPEYHQCYQLTDKSDVYSFGVVLIELISSMPAVDISRHRHEINLSTMAINKIQSNSLNELVDPSLGFESDYAARKMIRAVAELAFQCLQNAKELRPSMEEVLQILKEIQSRDYNAE--KAEDINSPSDDVGMLKSGPIPPSPDTVTVTWISTSSTPHAS 685          

Query:  919 SQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPL 1959
            S+SI S PS  SK+  +K  +Y GV +FSY ELEEAT NF+  +ELGDGGFGTVYYGKL DGR VAVKRLYENN+KR+EQF+NEV+ILTRL H+NLV LYGCTSR SRELLLVYEYIPNGT+ADHLHG+R + G L+   R++IA+ETA ALA+LH +D++HRDVKT NIL+ NDFCVKVADFGLSRLFP DVTHVSTAPQGTPGYVDP+Y+QCYQLTDKSDVYSFGVVLIELISS+ AVD +RHRH+INL+NMAINKIQ++ +NELVDP L FE+++  R+M +AVAELAF+CLQ  R++RP+M++V++ L+ IQ+ D  +E  +A  +DI +DDV LL++ P PL
Sbjct:   21 SRSIKSVPS--SKAYMEKRGSYNGVHLFSYDELEEATNNFDETRELGDGGFGTVYYGKLPDGREVAVKRLYENNYKRLEQFLNEVDILTRLRHKNLVLLYGCTSRHSRELLLVYEYIPNGTLADHLHGQRAKPGALTCRTRMNIAVETASALAYLHASDIVHRDVKTTNILLGNDFCVKVADFGLSRLFPLDVTHVSTAPQGTPGYVDPDYHQCYQLTDKSDVYSFGVVLIELISSMPAVDISRHRHEINLSNMAINKIQSNALNELVDPSLGFESDYAARKMISAVAELAFQCLQSARELRPSMEKVVEILKDIQSRDYTAE--RAEEIDIPSDDVVLLKSGPIPL 363          

Query:  991 VQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDG 1893
            V+VFSY ELEEAT  F+ +KELGDGGFGTVYYG L+DG VVAVKRLYE+N +R EQFMNE+EIL  L H+NLV+LYGCTSR SRELLLVYEYIPNGTVADHLHG++  SG L+WPVRLSIAIETA ALA+LH +DVIHRDVKTNNIL+DNDF VKVADFGLSRLFP DVTHVSTAPQGTPGYVDPEYYQCY LT+KSDVYS+GVVLIELIS+L+AVD  RHRHDINL+NMA+NKIQNH +NELVDP L F+ + VVR M ++VAELAF CLQ ER+MRPTM+EVL+ LR I+ E+ G+  G
Sbjct:  250 VRVFSYNELEEATNCFDSSKELGDGGFGTVYYGVLRDGCVVAVKRLYESNMRRAEQFMNEIEILAHLRHKNLVELYGCTSRHSRELLLVYEYIPNGTVADHLHGRQSNSGLLTWPVRLSIAIETASALAYLHASDVIHRDVKTNNILLDNDFHVKVADFGLSRLFPTDVTHVSTAPQGTPGYVDPEYYQCYHLTNKSDVYSYGVVLIELISALEAVDITRHRHDINLSNMAVNKIQNHALNELVDPFLGFDKDFVVREMVSSVAELAFMCLQHEREMRPTMEEVLEVLRGIERENYGAGKG 550          

Query:   55 VTTSFPSN--ANLSNCSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDS-PELTISSLSYRVLQLDPVRRNLKLARSDLW-TSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVA-NRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNG-LCGFDSDSSEPVCICGNRVC 741
            +T + PSN  +NLSNC++ F CG L N++YPFTGG R  +CGPPEF + C  +S   L  +S +YRV Q+D   + L+L+  D +  + CT    ++T     F+   + +  +S+FYGC +     + ++ F C      ++ ++++G  P        +C+    VP  ++ A +  A   SL  + + EGF V+Y NPY   C +C   +G  CGF  D   P+CIC +++C
Sbjct:   22 LTATSPSNDMSNLSNCNQTFSCGALTNITYPFTGGERPYHCGPPEFQLTCDGNSLTTLKANSQTYRVTQVDQANQTLRLSPLDFYGDNPCTYPSTSTTFDNVIFSLGSNHET-LSLFYGCKNLGGYVEANSKFSCGGPGDSEEGFFIIGDHP-----PVDRCQTSFQVPFPRSWAQQPQAEGLSLLVKVLKEGFDVSYRNPYSADCQKCYKHSGRQCGF--DGKVPICICDDQLC 248          

Query:  901 STNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGS 1884
            S+NL    S  S PS  SK+D +    Y  + +FSYTEL +AT NF+  KE+GDGGFGTVYYGKLQDGR VAVKRLYE+N+KRV+QFMNE+EILTRL H+NLV LYGCTSRRSRELLLVYEYIPNGTVADHLHG + +S  L+WP+R+SIAIETA ALA+LH +D+IHRDVKTNNIL+DN+F VKVADFGLSRLFP DVTHVST PQGTPGYVDPEY+Q YQLTDKSDVYSFGVVLIELISS+ AVD  RHRH+INL+N+AI+KIQ    +EL+D  L + ++  V+RM T+VAELAF+CLQQ+++ RP+M+ VL  L+ IQ  ++ +
Sbjct:   20 SSNLLSMNS-SSDPS--SKADLEGDGVYLSIPIFSYTELGQATNNFDSEKEVGDGGFGTVYYGKLQDGREVAVKRLYEHNYKRVKQFMNEIEILTRLHHKNLVCLYGCTSRRSRELLLVYEYIPNGTVADHLHGDQAKSSPLTWPIRMSIAIETASALAYLHASDIIHRDVKTNNILLDNNFSVKVADFGLSRLFPKDVTHVSTVPQGTPGYVDPEYHQSYQLTDKSDVYSFGVVLIELISSMPAVDITRHRHEINLSNLAISKIQKCAFDELIDSRLGYNSDEEVKRMTTSVAELAFQCLQQDKETRPSMENVLQQLKIIQGGEISN 344          

Query:   46 SFEVTTSFPSNANLSNCSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRVCDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYD-KGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTDKL 1989
            S +VT SFP++A+LSNC++ FDCGP RNL+YPFTG +R +YCGPPEFH++C++D+PELTI++LSYRVL+LDPV  NL LARSDLW STCTDK+ NST++ EFF Y++ DD+ V+IFYGCNST+ +PK  NWF C+ +L F D+YY++GP PLDPIMS FKC +GITVPILKTTAA LVANRSLF EAI  GF VNYTNPY+ QCA+CL VNGLCGFDSD + PVCICGNRVC+PAGLAV                  Q          QSKE+PTPLTSK VATPST+LSQ QSIPSY SFT KSDYD KGSTYFGVQVFSY ELEEATENFNPAKELGDGGFGTVYYGKL DGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESG LSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIEL+SSLQAVDTNRHRHDINLAN+A+NKIQNHLVNELVDP L +ETN+ VR+M TAVAELAFRCLQQERDMRPTMDEVL+GL+A+QNEDLGSE+G+AVVLDI +D+VGLLRNMPPPLSPDS G DKL
Sbjct:   13 SVDVTRSFPADADLSNCTQTFDCGPFRNLTYPFTGRARPSYCGPPEFHLSCIDDTPELTIAALSYRVLKLDPVHENLTLARSDLWNSTCTDKLGNSTLESEFFTYDDDDDMDVTIFYGCNSTLISPKPENWFFCDLNLTFDDAYYVIGPAPLDPIMSGFKCSVGITVPILKTTAAVLVANRSLFGEAIMTGFNVNYTNPYEKQCAKCLNVNGLCGFDSDKNRPVCICGNRVCNPAGLAVGGAILFGVFVGFYVYYFIQRKKKKLAAQTQSKELPTPLTSKGVATPSTDLSQFQSIPSYXSFTXKSDYDNKGSTYFGVQVFSYNELEEATENFNPAKELGDGGFGTVYYGKLHDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGCLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELLSSLQAVDTNRHRHDINLANLAVNKIQNHLVNELVDPHLGYETNYSVRQMTTAVAELAFRCLQQERDMRPTMDEVLEGLKAVQNEDLGSENGEAVVLDIRSDEVGLLRNMPPPLSPDSNGADKL 661          

Query:  382 VSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRVCDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYD-KGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTDKL 1989
            V+IFYGCNST+ +PK  NWF C+ +L F D+YY++GPVPLDPIMS FKC +GITVPILKTTAA LVANRSLF EAI  GF VNYTNPY+ QCA+CL VNGLCGFDSD + PVCICGNRVC+PAGLAV                  Q          QSKE+PTPLTSK VATPST+LSQ QSIPSYPSFT KSDYD KGSTYFGVQVFSY ELEEATENFNPAKELGDGGFGTVYYGKL DGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESG LSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIEL+SSLQAVDTNRHRHDINLAN+A+NKIQNHLVNELVDP L +ETN+ VR+M TAVAELAFRCLQQERDMRPTMDEVL+GL+A+QNEDLGSE+G+AVVLDI +D+VGLLRNMPPPLSPDS G DKL
Sbjct:    3 VTIFYGCNSTLISPKPKNWFFCDLNLTFDDAYYVIGPVPLDPIMSGFKCSVGITVPILKTTAAVLVANRSLFGEAIMTGFNVNYTNPYEKQCAKCLNVNGLCGFDSDKNRPVCICGNRVCNPAGLAVGGAILFGVFVGFYVYYFIQRKKKKLAAQTQSKELPTPLTSKGVATPSTDLSQFQSIPSYPSFTCKSDYDNKGSTYFGVQVFSYNELEEATENFNPAKELGDGGFGTVYYGKLHDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGCLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELLSSLQAVDTNRHRHDINLANLAVNKIQNHLVNELVDPHLGYETNYSVRQMTTAVAELAFRCLQQERDMRPTMDEVLEGLKAVQNEDLGSENGEAVVLDIRSDEVGLLRNMPPPLSPDSNGADKL 539          

Query:  850 QSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYD-KGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTDKLVSSSTPPSSF 2019
            QSKE+PTPLTS SVATPSTNLSQSQSIPSYPSFTSK DYD K STYFGVQVF+YTELEEATENFNPAKELGDGGFGTVYYGKL DGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTS+RSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAI+TADALA+LHRNDVIHRDVK NNIL+D+DFCVKVADFGLSRLFPND THVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIEL+SSLQAVDTNRHR DINLAN+A+NKIQNHLVNELVDPLL FETN  VRRM TAVAELAFRCLQQE+DMRPTMDEVL GL+A+QNEDLGSE+G+AVVLDIGAD+VGLLRNMPPPLSPDS GTDKLVSSST PSSF
Sbjct:   49 QSKEVPTPLTSTSVATPSTNLSQSQSIPSYPSFTSKXDYDNKASTYFGVQVFTYTELEEATENFNPAKELGDGGFGTVYYGKLHDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSKRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIDTADALAYLHRNDVIHRDVKXNNILLDDDFCVKVADFGLSRLFPNDATHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELLSSLQAVDTNRHRLDINLANLAVNKIQNHLVNELVDPLLGFETNVSVRRMTTAVAELAFRCLQQEKDMRPTMDEVLKGLKAVQNEDLGSENGEAVVLDIGADEVGLLRNMPPPLSPDSNGTDKLVSSSTTPSSF 439          

Query:  925 SIPSYPSFTSKSDYD-KGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTDKLVSSSTPPSSF 2019
            SIPSY SFT KSDYD KGSTYFGVQVFSY ELEEATENFNPAKELGDGGFGTVYYGKL DGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESG LSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIEL+SSLQAVDTNRHRHDINLAN+A+NKIQNHLVNELVDP L +ETN+ VR+M TAVAELAFRCLQQERDMRPTMDEVL+GL+A+QNEDLGSE+G+AVVLDI +D+VGLLRNMPPPLSPDS G DKLVS ST PSSF
Sbjct:   55 SIPSYXSFTXKSDYDNKGSTYFGVQVFSYNELEEATENFNPAKELGDGGFGTVYYGKLHDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGCLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELLSSLQAVDTNRHRHDINLANLAVNKIQNHLVNELVDPHLGYETNYSVRQMTTAVAELAFRCLQQERDMRPTMDEVLEGLKAVQNEDLGSENGEAVVLDIRSDEVGLLRNMPPPLSPDSNGADKLVSGSTTPSSF 420          

Query:  511 MSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCL 669
            MS FKC + ITVPILKT  A LVANRSLF EAI  GF VNYTNPYD QCA+CL
Sbjct:    1 MSGFKCYVRITVPILKTMVAVLVANRSLFGEAIMTGFNVNYTNPYDKQCAKCL 53          

Query:  112 CGPLRNLSYPF-TGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSD-LWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNR----VCDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTDKLVSSSTPPSS 2016
            CG   N+SYPF   G++ ++CG P F I C    P L+IS   Y V ++     +  LA +  ++   C   + N +++   F Y+ S+ +  S FYGC        L     C ++ +          V      S   C+  + +P         +   + + E +  GF +N+T      C+ C    G CGFD++  E VC C +R     CD                  X       X          K    P    S  T     S         +++   D +KGSTY GV +FSY ELEEAT  F+ AKELGDGGFGTVY+G + DGR VAVKRLYENN+KRVEQFMNE+EIL RL H+NLV LYGCTSR+SRELLLVYEYIPNGT+A+HLHG R + G L W  R++IAIETA AL++LH +D+IHRDVKT NIL+DN+F VKVADFGLSRLFP +VTH+STAPQGTPGYVDPEY QCYQLT KSDVYSFGVVLIELISS+ AVD  RHRH+INL+ MAINKI+NH ++ELVDP L FE++   R+M  AVAELAFRCLQ ++D+RP+M EVL+ L+ IQ++D   +  +A  +DI ADD+  L++ P P SPDS   +    S+TP  S
Sbjct:   35 CGXGPNISYPFWLSGNQDSFCGYPSFKITCNGRFPVLSISGDEYIVKEIFYSNHSFVLANAAAVYDEKCPLPLHNFSLERTPFKYS-SNHVNFSFFYGCPEEPLEYMLPYPIDCASNGSHHSFAIFHMEVVERMSYSLDSCQSSVHLPFDDAVXVDALMQMN-YTEILKMGFILNWTA---QNCSNCQRSGGRCGFDNN--EFVCFCSDRPHVKTCDDDNPWNWKRKVIVGVCTAXATVAIMCXIFFVYQRRNRK----PYDXSSFVTRGILSS---------TYSMDDDMEKGSTYLGVHIFSYKELEEATNYFDSAKELGDGGFGTVYHGNVHDGRAVAVKRLYENNWKRVEQFMNEIEILARLRHQNLVLLYGCTSRQSRELLLVYEYIPNGTLAEHLHGGRAKPGALPWLTRINIAIETASALSYLHASDIIHRDVKTTNILLDNNFGVKVADFGLSRLFPMNVTHISTAPQGTPGYVDPEYNQCYQLTSKSDVYSFGVVLIELISSMPAVDITRHRHEINLSTMAINKIKNHTLHELVDPYLGFESDSRTRKMIIAVAELAFRCLQTDKDVRPSMVEVLNELKWIQSDDFNIQ--KAEEIDILADDIVPLKSDPLPPSPDSVALNLTSXSTTPNGS 653          

Query:  904 TNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQN-----EDLGSE-DGQAVVLDI------GADDVGLLRNMPPPLSPDSAGTDKLVSSSTPPSS 2016
            ++L  S++I S P   + SD + G  Y G  VFSY EL+EAT  F+   ELGDGGFGTVY GKL+DGR VAVKRLYE+N+KRVEQF+NE+EILTRL HRNLV LYGCTSRRSRELLLVYEYI NGTVADHLHG R + G L+WP+R+SIAIETADAL++LH ++++HRDVKTNNIL+D++FCVKVADFGLSRLFP DVTHVSTAPQGTPGYVDPEY++CYQLT KSDVYSFGVVLIELISSL AVD  RHRH+INLAN+AI+KIQ  L NELVD  L FE++  VRRM  AVAELAF+CLQQ+ ++RPTM+EVL+ L+ I++     E+L  E D ++V   +       +D++GLL   PPP SP S       + ST P++
Sbjct:  299 SSLFLSRNISSQPX--TNSDIEXGGAYCGXPVFSYXELDEATNXFDSEXELGDGGFGTVYXGKLKDGREVAVKRLYEHNYKRVEQFINEIEILTRLRHRNLVSLYGCTSRRSRELLLVYEYISNGTVADHLHGDRADPGSLTWPIRMSIAIETADALSYLHASEIVHRDVKTNNILLDDNFCVKVADFGLSRLFPXDVTHVSTAPQGTPGYVDPEYHECYQLTSKSDVYSFGVVLIELISSLPAVDIMRHRHEINLANLAISKIQKGLFNELVDQRLGFESDGEVRRMIIAVAELAFQCLQQDNNVRPTMNEVLEALKMIESGSYVPENLKPEXDSESVKTSVQPPASPDSDEIGLLNVRPPP-SPVSVTQKWPSTRSTSPNA 678          

Query:  904 TNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQN-----EDLGSE-DGQAVVLDI------GADDVGLLRNMPPPLSPDSAGTDKLVSSSTPPSS 2016
            ++L  S++I S P   + SD + G  Y G  VFSY EL+EAT  F+   ELGDGGFGTVY GKL+DGR VAVKRLYE+N+KRVEQF+NE+EILTRL HRNLV LYGCTSRRSRELLLVYEYI NGTVADHLHG R + G L+WP+R+SIAIETADAL++LH ++++HRDVKTNNIL+D++FCVKVADFGLSRLFP DVTHVSTAPQGTPGYVDPEY++CYQLT KSDVYSFGVVLIELISSL AVD  RHRH+INLAN+AI+KIQ  L NELVD  L FE++  VRRM  AVAELAF+CLQQ+ ++RPTM+EVL+ L+ I++     E+L  E D ++V   +       +D++GLL   PPP SP S       + ST P++
Sbjct:  325 SSLFLSRNISSQPX--TNSDIEXGGAYCGXPVFSYXELDEATNXFDSEXELGDGGFGTVYXGKLKDGREVAVKRLYEHNYKRVEQFINEIEILTRLRHRNLVSLYGCTSRRSRELLLVYEYISNGTVADHLHGDRAD-GSLTWPIRMSIAIETADALSYLHASEIVHRDVKTNNILLDDNFCVKVADFGLSRLFPXDVTHVSTAPQGTPGYVDPEYHECYQLTSKSDVYSFGVVLIELISSLPAVDIMRHRHEINLANLAISKIQKGLFNELVDQRLGFESDGEVRRMIIAVAELAFQCLQQDNNVRPTMNEVLEALKMIESGSYVPENLKPEXDSESVKTSVQPPASPDSDEIGLLNVRPPP-SPVSVTQKWPSTRSTSPNA 703          

Query:   46 SFEVTTSFPSNANLSNCSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRVCDPAGLA 759
            S +VT SFP++A+LSNC++ FDCGP RNL+YPFTGGSR +YCGPPEFH++CV+DSPELTI+SLSYRVL+L PV +NL LARSDLW STCTDK+ NST++  FF+Y+E DD+ V+IFYGCNST+  PK  NWF C+ +L F D+YY++GPVP+DPIMS FKC +GITVPILKTTAA LVANRSLF EAI  GF VNYTNPY+ QCA+CL VNGLCGFDSD + PVCICGNRVC+PAG++
Sbjct:   91 SVDVTXSFPADADLSNCTQTFDCGPFRNLTYPFTGGSRPSYCGPPEFHLSCVDDSPELTIASLSYRVLKLXPVHQNLTLARSDLWNSTCTDKLANSTLESVFFSYDEDDDMDVTIFYGCNSTLIXPKPKNWFXCDLNLTFDDAYYVIGPVPVDPIMSGFKCSVGITVPILKTTAAVLVANRSLFGEAIMTGFNVNYTNPYEKQCAKCLNVNGLCGFDSDKNRPVCICGNRVCNPAGIS 328          

Query:   46 SFEVTTSFPSNANLSNCSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRVCDPAGLA 759
            S +VT SFP++A+LSNC++ FDCGP RNL+YPFTG +R +YCGPPEFH++C++D+PELTI++LSYRVL+LDPV  NL LARSDLW STCTDK+ NST++ EFF Y++ DD+ V+IFYGCNST+ +PK  NWF C+ +L F D+YY++GP PLDPIMS FKC +GITVPILKTTAA LV NRSLF EAI  GF V+YTNPY+ QCA+CL VNGLCGFDSD + PVCICGNRVC+PAG++
Sbjct:   13 SVDVTRSFPADADLSNCTQTFDCGPFRNLTYPFTGRARPSYCGPPEFHLSCIDDTPELTIAALSYRVLKLDPVHENLTLARSDLWNSTCTDKLGNSTLESEFFTYDDDDDMDVTIFYGCNSTLISPKPENWFFCDLNLTFDDAYYVIGPAPLDPIMSGFKCSVGITVPILKTTAAVLVGNRSLFGEAIKTGFNVHYTNPYEKQCAKCLNVNGLCGFDSDKNRPVCICGNRVCNPAGIS 250          

Query:   46 SFEVTTSFPSNANLSNCSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRVCDPAGL 756
            S +V TSFP++A+LSNC++ FDCGPLRNL+YPFTGG+R +YCGPPEFH+ CV+DSPELTI  LSYR+L+LDP  +N+ +ARSDLW STCTDK+ NST++ EFF Y++ DD+ V+IFYGCNST   P   NWF C+ +  F+D+YYL+GPVPLDPI+S FKC +GITVPILKTTAA LV NRSLF+EAI  GF VNYTNPY+ QCA+CL VNGLCGFDSD + PVCICG R+CDPAG+
Sbjct:   16 SVDVATSFPAHADLSNCTQTFDCGPLRNLTYPFTGGTRPSYCGPPEFHLTCVDDSPELTIGLLSYRILKLDPAHQNMTVARSDLWNSTCTDKLANSTLESEFFXYDDDDDMDVTIFYGCNSTFIDPXPQNWFLCDLNFPFKDAYYLIGPVPLDPIVSXFKCXVGITVPILKTTAAVLVGNRSLFKEAIMAGFNVNYTNPYEKQCAECLNVNGLCGFDSDKNRPVCICGKRLCDPAGI 252          

Query:   58 TTSFPSNANLSNCSRV-FDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNST-ITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNG-LCGFDSDSSEPVCICGNRVCDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLS------------QSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTDKLVSSSTPPSS 2016
            TTS PS+A+LS+C+   F+CG +  LSYPFTGG R +YCGPP+FH+NC N+ PEL ISS+SYRVLQ++ V  +L LAR DLW  TCT    NST     F+ N   +  +++FYGC  T + T K  N F+C+++    +SY L+GP PLDP++   +C+ G+ VPIL+  A +   NRSL +E + EGF VNY NP++N C +C+   G  CGFDSD +E +CICGN +C P+G +                              + K    P+++     PS+  S             SQSIPSYPS  SK+     S YFGVQVF+Y ELEEAT NF+ +KELG+GGFGTVY G L+DGRVVAVKR YE+NFKRV QFMNEVEIL RL H+NLV LYGCTS+ SRELLLVYEYI NGTVADHLHG R  S  L W VRL IA+ETA+ALA+LH +DV+HRDVK+NNIL+D  F VKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVL+ELISSLQAVD  RHR+D+NLANMA+NKIQ+  + +LVDP L +E ++ V+RM TAVAELAFRCLQQ+RD+RP+MDE+++ LRAI++++  +++ + + + +  D++ LL+  P P SPDS     +  SST  SS
Sbjct:  519 TTSLPSHASLSSCNNTTFNCGHITKLSYPFTGGDRPSYCGPPQFHLNCKNNVPELNISSVSYRVLQVNSVTHSLTLARLDLWNETCTHHYVNSTFGGTSFS-NGLGNSKITLFYGCQPTSLFTEKPHNLFYCDSNGYKNNSYTLIGPFPLDPVLKFVQCDYGVGVPILEEQANRFAGNRSLLREVLMEGFNVNYNNPFENDCLECISSGGQQCGFDSDENEHICICGNGLC-PSGNSSTNGGLIGGVVGGVAALCLLGFVACFVVRRRRKNAKKPISNDLYMPPSSTTSGTNTGTLTSTTNSSQSIPSYPS--SKTSTMPKSFYFGVQVFTYEELEEATNNFHTSKELGEGGFGTVYKGDLKDGRVVAVKRHYESNFKRVAQFMNEVEILARLRHKNLVTLYGCTSKHSRELLLVYEYISNGTVADHLHGDRSSSCLLPWSVRLDIALETAEALAYLHASDVMHRDVKSNNILLDEKFHVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLVELISSLQAVDITRHRNDVNLANMAVNKIQSQELYDLVDPNLGYEKDNSVKRMTTAVAELAFRCLQQQRDLRPSMDEIVEVLRAIKSDEPETQESKVLDVVVRTDELVLLKKGPYPTSPDSVAEKWVSGSSTSTSS 1182          

Query:  103 VFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNST--ITTPKLSNWFHCNNSLAFQDSYYLLGPV-----PLDPIMSTFK-CEIGITVPILKTTAAKLVANRSL--FQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCIC 726
            +FDC  L+NL YPF G SR  YCG P F + C ++   +TI S +Y++L++      LK+ R+D W + C   + N+T+   FF Y  SD   ++++Y C  T  +     S  F+C+ +     +Y++L  V      LD    T + C+  + VP L++ A ++  N S+   ++ I+ GF V + N  ++ C +C    G CG++S S E  C C
Sbjct:  265 LFDCANLKNLRYPFWGSSRPQYCGHPSFELQCKDELASITIMSQNYKILEVSDSDHRLKVVRTDYWNNVCPTSLKNTTLDCTFFDYG-SDSHNLTLYYDCPHTPFLMPDSFSPQFNCSINGTQMVNYFMLESVADNAESLDSFSETLRTCKSRVVVPFLESEAERVATNSSVENLKDVIDNGFGVEW-NANNSLCHECQSSGGHCGYESSSREFTCFC 480          

Query:   88 SNCSRVFDCGP--LRNLSYPFTGGSRSAYCGP---PEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCT------DKVFNSTMK--PEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVC-------ICGNRVCDPAGLAV 762
            ++C+  F+CG   + NL YPF G +R   CG    P   + C    P++TI+ + YR+L+ D   + L +AR D W   CT      DK  NST +   +F  Y  S    +++ Y C++T+     S   +C  ++   +  Y L     DP   +  C + + + I    +   + N     EA+  GF + +   Y + C +C+   G CG +       C       ICG+R    + +++
Sbjct:   34 TDCNEAFECGSSSITNLKYPFWGNNREERCGSVSDPNMELTCEESVPKITINDVKYRILEWDNTTQKLTVARDDYWGGICTVSVSVSDKPNNSTFESADQFQPYG-SVSSQLNLLYNCDTTVLNVVYS--ANCGGNI---EVVYTLS----DPRSLSLTCNLSVIIAI--PISVTRITNLDDINEALQGGFDLRWMGNYAD-CQRCVDSGGACGNNGTEFRCFCNDGAYTDICGSRKAPTSSISL 265          

Query:   58 TTSFPSNANLSNCSRV-FDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNST-ITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNG-LCGFDSDSSEPVCICGNRVCDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLS------------QSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDS 1971
            TTS PS+A+LS+C+   F+CG +  LSYPFTGG R +YCGPP+FH+NC N+ PEL ISS+SYRVLQ++ V  +L LAR DLW  TCT    NST     F+ N   +  +++FYGC  T + T K  N F+C+++    +SY L+GP PLDP++   +C+ G+ VPIL+  A +   NRSL +E + EGF VNY NP++N C +C+   G  CGFDSD +E +CICGN +C P+G +                              + K    P+++     PS+  S             SQSIPSYPS  SK+     S YFGVQVF+Y ELEEAT NF+ +KELG+GGFGTVY G L+DGRVVAVKR YE+NFKRV QFMNEVEIL RL H+NLV LYGCTS+ SRELLLVYEYI NGTVADHLHG R  S  L W VRL IA+ETA+ALA+LH +DV+HRDVK+NNIL+D  F VKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVL+ELISSLQAVD  RHR+D+NLANMA+NKIQ+  + +LVDP L +E ++ V+RM TAVAELAFRCLQQ+RD+RP+MDE+++ LRAI++++  +++ + + + +  D++ LL+  P P SPDS
Sbjct:  519 TTSLPSHASLSSCNNTTFNCGHITKLSYPFTGGDRPSYCGPPQFHLNCKNNVPELNISSVSYRVLQVNSVTHSLTLARLDLWNETCTHHYVNSTFGGTSFS-NGLGNSKITLFYGCQPTSLFTEKPHNLFYCDSNGYKNNSYTLIGPFPLDPVLKFVQCDYGVGVPILEEQANRFAGNRSLLREVLMEGFNVNYNNPFENDCLECISSGGQQCGFDSDENEHICICGNGLC-PSGNSSTNGGLIGGVVGGVAALCLLGFVACFVVRRRRKNAKKPISNDLYMPPSSTTSGTNTGTLTSTTNSSQSIPSYPS--SKTSTMPKSFYFGVQVFTYEELEEATNNFHTSKELGEGGFGTVYKGDLKDGRVVAVKRHYESNFKRVAQFMNEVEILARLRHKNLVTLYGCTSKHSRELLLVYEYISNGTVADHLHGDRSSSCLLPWSVRLDIALETAEALAYLHASDVMHRDVKSNNILLDEKFHVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLVELISSLQAVDITRHRNDVNLANMAVNKIQSQELYDLVDPNLGYEKDNSVKRMTTAVAELAFRCLQQQRDLRPSMDEIVEVLRAIKSDEPETQESKVLDVVVRTDELVLLKKGPYPTSPDS 1167          

Query:  103 VFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNST--ITTPKLSNWFHCNNSLAFQDSYYLLGPV-----PLDPIMSTFK-CEIGITVPILKTTAAKLVANRSL--FQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCIC 726
            +FDC  L+NL YPF G SR  YCG P F + C ++   +TI S +Y++L++      LK+ R+D W + C   + N+T+   FF Y  SD   ++++Y C  T  +     S  F+C+ +     +Y++L  V      LD    T + C+  + VP L++ A ++  N S+   ++ I+ GF V + N  ++ C +C    G CG++S S E  C C
Sbjct:  265 LFDCANLKNLRYPFWGSSRPQYCGHPSFELQCKDELASITIMSQNYKILEVSDSDHRLKVVRTDYWNNVCPTSLKNTTLDCTFFDYG-SDSHNLTLYYDCPHTPFLMPDSFSPQFNCSINGTQMVNYFMLESVADNAESLDSFSETLRTCKSRVVVPFLESEAERVATNSSVENLKDVIDNGFGVEW-NANNSLCHECQSSGGHCGYESSSREFTCFC 480          

Query:   88 SNCSRVFDCGP--LRNLSYPFTGGSRSAYCGP---PEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCT------DKVFNSTMK--PEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVC-------ICGNRVCDPAGLAV 762
            ++C+  F+CG   + NL YPF G +R   CG    P   + C    P++TI+ + YR+L+ D   + L +AR D W   CT      DK  NST +   +F  Y  S    +++ Y C++T+     S   +C  ++   +  Y L     DP   +  C + + + I    +   + N     EA+  GF + +   Y + C +C+   G CG +       C       ICG+R    + +++
Sbjct:   34 TDCNEAFECGSSSITNLKYPFWGNNREERCGSVSDPNMELTCEESVPKITINDVKYRILEWDNTTQKLTVARDDYWGGICTVSVSVSDKPNNSTFESADQFQPYG-SVSSQLNLLYNCDTTVLNVVYS--ANCGGNI---EVVYTLS----DPRSLSLTCNLSVIIAI--PISVTRITNLDDINEALQGGFDLRWMGNYAD-CQRCVDSGGACGNNGTEFRCFCNDGAYTDICGSRKAPTSSISL 265          

Query:   58 TTSFPSNANLSNCSRV-FDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNST-ITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNG-LCGFDSDSSEPVCICGNRVCDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLS------------QSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDS 1971
            TTS PS+A+LS+C+   F+CG +  LSYPFTGG R +YCGPP+FH+NC N+ PEL ISS+SYRVLQ++ V  +L LAR DLW  TCT    NST     F+ N   +  +++FYGC  T + T K  N F+C+++    +SY L+GP PLDP++   +C+ G+ VPIL+  A +   NRSL +E + EGF VNY NP++N C +C+   G  CGFDSD +E +CICGN +C P+G +                              + K    P+++     PS+  S             SQSIPSYPS  SK+     S YFGVQVF+Y ELEEAT NF+ +KELG+GGFGTVY G L+DGRVVAVKR YE+NFKRV QFMNEVEIL RL H+NLV LYGCTS+ SRELLLVYEYI NGTVADHLHG R  S  L W VRL IA+ETA+ALA+LH +DV+HRDVK+NNIL+D  F VKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVL+ELISSLQAVD  RHR+D+NLANMA+NKIQ+  + +LVDP L +E ++ V+RM TAVAELAFRCLQQ+RD+RP+MDE+++ LRAI++++  +++ + + + +  D++ LL+  P P SPDS
Sbjct:  519 TTSLPSHASLSSCNNTTFNCGHITKLSYPFTGGDRPSYCGPPQFHLNCKNNVPELNISSVSYRVLQVNSVTHSLTLARLDLWNETCTHHYVNSTFGGTSFS-NGLGNSKITLFYGCQPTSLFTEKPHNLFYCDSNGYKNNSYTLIGPFPLDPVLKFVQCDYGVGVPILEEQANRFAGNRSLLREVLMEGFNVNYNNPFENDCLECISSGGQQCGFDSDENEHICICGNGLC-PSGNSSTNGGLIGGVVGGVAALCLLGFVACFVVRRRRKNAKKPISNDLYMPPSSTTSGTNTGTLTSTTNSSQSIPSYPS--SKTSTMPKSFYFGVQVFTYEELEEATNNFHTSKELGEGGFGTVYKGDLKDGRVVAVKRHYESNFKRVAQFMNEVEILARLRHKNLVTLYGCTSKHSRELLLVYEYISNGTVADHLHGDRSSSCLLPWSVRLDIALETAEALAYLHASDVMHRDVKSNNILLDEKFHVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLVELISSLQAVDITRHRNDVNLANMAVNKIQSQELYDLVDPNLGYEKDNSVKRMTTAVAELAFRCLQQQRDLRPSMDEIVEVLRAIKSDEPETQESKVLDVVVRTDELVLLKKGPYPTSPDS 1167          

Query:  103 VFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNST--ITTPKLSNWFHCNNSLAFQDSYYLLGPV-----PLDPIMSTFK-CEIGITVPILKTTAAKLVANRSL--FQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCIC 726
            +FDC  L+NL YPF G SR  YCG P F + C ++   +TI S +Y++L++      LK+ R+D W + C   + N+T+   FF Y  SD   ++++Y C  T  +     S  F+C+ +     +Y++L  V      LD    T + C+  + VP L++ A ++  N S+   ++ I+ GF V + N  ++ C +C    G CG++S S E  C C
Sbjct:  265 LFDCANLKNLRYPFWGSSRPQYCGHPSFELQCKDELASITIMSQNYKILEVSDSDHRLKVVRTDYWNNVCPTSLKNTTLDCTFFDYG-SDSHNLTLYYDCPHTPFLMPDSFSPQFNCSINGTQMVNYFMLESVADNAESLDSFSETLRTCKSRVVVPFLESEAERVATNSSVENLKDVIDNGFGVEW-NANNSLCHECQSSGGHCGYESSSREFTCFC 480          

Query:   88 SNCSRVFDCGP--LRNLSYPFTGGSRSAYCGP---PEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCT------DKVFNSTMK--PEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVC-------ICGNRVCDPAGLAV 762
            ++C+  F+CG   + NL YPF G +R   CG    P   + C    P++TI+ + YR+L+ D   + L +AR D W   CT      DK  NST +   +F  Y  S    +++ Y C++T+     S   +C  ++   +  Y L     DP   +  C + + + I    +   + N     EA+  GF + +   Y + C +C+   G CG +       C       ICG+R    + +++
Sbjct:   34 TDCNEAFECGSSSITNLKYPFWGNNREERCGSVSDPNMELTCEESVPKITINDVKYRILEWDNTTQKLTVARDDYWGGICTVSVSVSDKPNNSTFESADQFQPYG-SVSSQLNLLYNCDTTVLNVVYS--ANCGGNI---EVVYTLS----DPRSLSLTCNLSVIIAI--PISVTRITNLDDINEALQGGFDLRWMGNYAD-CQRCVDSGGACGNNGTEFRCFCNDGAYTDICGSRKAPTSSISL 265          

Query:   73 SNANLSNCSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSY-YLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANR---SLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGN--------RVCDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTDKLVSSSTPPS 2013
            +N    +C   ++CG + N+SYPF GGSR  YCG P F + C  ++P  T+   SYR+L ++     L +AR+D W S C     N+T+    F+YN +    V+++Y C      P  SN F+C N   +  +  + LG       +S   C + +TVPI K+ A  +V+     +L  EA+  GF + + N  ++ C +C+   G CG+ S+     C C N             +G +V                  Q          +SK++PTP +SK +A   T  S+S  IPSYP   +KSD +KGSTYFGVQVFSY ELEEAT NF+P++ELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEV+ILTRL+H+NLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGK+  SG ++WPVRLSIAIETA+ALA+LH +++IHRDVKTNNIL+DN+F VKVADFGLSRLFP DVTHVSTAPQGTPGYVDPEY+QCYQLT KSDVYSFGVVL+ELISS QAVDTNRHRHDINLANMA+NKI NH ++ELVDP L FE++ +VRR  T VAELAFRCLQ ERDMRPTM EVL  LR I+NE+  S+  +A  +DI ++D+GLL++ PPP+SPDS   DK V+ +TP S
Sbjct:   11 ANQQFVSCGAQYECGNM-NISYPFWGGSRPPYCGHPGFELTCNGEAPVFTMKEASYRILDINNSFHTLTVARADYWDSYCPPTYVNTTLNESIFSYNATYTD-VTLYYDCPQLTIAP--SNQFNCTNITGYYTTLDFNLG-------VSIGSCSVYVTVPIFKSAATAIVSGGGTLTLLTEALKGGFGLEW-NASNSLCTECVESGGQCGYTSNQF--TCYCRNGYSPSTCQNTTSASGYSVLGAVLLGIFLGCLFYFLAQRRRRASKA--KSKDLPTPPSSKGIAPSLTGFSES--IPSYPY--TKSDIEKGSTYFGVQVFSYMELEEATNNFDPSRELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVQILTRLQHQNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKQANSGSITWPVRLSIAIETANALAYLHESEIIHRDVKTNNILLDNNFQVKVADFGLSRLFPTDVTHVSTAPQGTPGYVDPEYHQCYQLTSKSDVYSFGVVLMELISSKQAVDTNRHRHDINLANMAVNKILNHTLHELVDPSLGFESDSLVRRKITLVAELAFRCLQHERDMRPTMGEVLKALRRIENEE--SDVQKAEEVDINSEDIGLLKSNPPPVSPDSVVADKGVNPTTPYS 647          

Query:   58 TTSFPSNANLSNCSRV-FDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDS-PELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNST---ITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRVCDPAGL--------AVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVES-GFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNED-LGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTDKLVSSSTPPSS 2016
            TTS P +A LS+C    F+CG + NLSYPFTGG R ++CGPP+F +NC N    EL ISS+SYRV+ +D     L LAR DLW  TCTD   NST     F+Y   +   +++FY C  T   I TP+  N F+C ++    +SY L+GP PLDPI+   +C+  + VPILK  A +LV NRSL  E + +GF VNY NPY+++C +CL   G+CGFDSD+ E +CICG+ +C   G         A                   Q          +S E+    +S      +TN SQS S  SY S ++       S YFGVQVF+Y ELEEAT+NF+ ++ELG+GGFGTVY G+L+DGRVVAVKR YE+N +R+EQFMNEV+IL RL H++LV L+GCTSR SRELLLVYE+IPNGTVADHL G+   S   L WPVRL+IA+ETA+ALA+LH NDVIHRDVKTNNIL+D++F VKVADFGLSR FPN VTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVL+ELISSLQAVD NR+R D+NLANMAINKIQN  ++ELVDP L FE ++ +RRM T VAELAFRCLQQER++RP+M+EV++ LR I+++D LG+ + +  VL++  D+  LL+ +  P+SPDS   DK  S S+  +S
Sbjct:  817 TTSLPPHATLSSCHVTSFNCGSITNLSYPFTGGDRPSFCGPPQFLLNCRNGVVAELNISSVSYRVIDIDSEDHTLTLARLDLWNETCTDVYVNSTFDGPVFSYGSGNQ-NLTLFYECKPTSRIIETPE--NLFNCWSNGDKNNSYSLVGPFPLDPILEVVECDEHVKVPILKVQADRLVENRSLLGEVLMKGFNVNYMNPYESECFECLDSGGVCGFDSDNDEHICICGDHLCATPGSSKVGVAIGASIGAVVALVVILGCVYFVMQRRRKTAYNKQRSMELFIAPSSGDTFASTTNTSQSLS--SYQS-SNTDPMPPRSYYFGVQVFTYEELEEATKNFDSSRELGEGGFGTVYKGQLKDGRVVAVKRHYESNSRRIEQFMNEVQILARLRHKSLVTLFGCTSRHSRELLLVYEFIPNGTVADHLQGRSSNSTNLLPWPVRLNIAVETAEALAYLHANDVIHRDVKTNNILLDDNFRVKVADFGLSRDFPNHVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLVELISSLQAVDINRNRSDVNLANMAINKIQNQELHELVDPYLGFERDYAIRRMTTGVAELAFRCLQQEREIRPSMNEVVEILRGIKSDDGLGARE-ETEVLEVRIDEARLLKKV-SPVSPDSV-VDKCFSGSSVSNS 1475          

Query:   55 VTTSFPSNANLSNCSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGC---------------NSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSL--FQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCIC 726
            +T+    + +   C   F C  L+NLSYPF G SR  YCG P F + C  +   +TI S +YRVL+++     +KL R+D W +TC   + N T+   FF Y  SD   ++++Y C               N ++   +++N+F   + LA  ++      V +  I+    C+  + VPIL++ A  L  N ++   + A+  GF V +    ++ C +C    G CG+D  SSE  C C
Sbjct:  564 LTSCAADDVHYLKCGSPFHCANLKNLSYPFWGFSRPLYCGHPAFKLQCTGEVATVTIMSENYRVLEVNDSDHRIKLVRTDYWNNTCPTSLRNFTIGCTFFDYG-SDSRNLTLYYDCSSPSFLQPDSFPPKFNCSVNGTQMNNYFVDESMLANAET-----SVSISEILGA--CKSRVVVPILESEAEVLETNSTVENLKAALENGFGVEW-EANNSLCDECQNSGGHCGYDPISSEFACHC 795          

Query:   76 NANLSNCSRVFDCGPLR-NLSYPFTGGSRSAYCGP-PEFH---INCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLW--TSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTIT-------TPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFK--CEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCG 690
            +A+ +NCS  F CG    NL YPF G +R  YCG  P      + C    P++TI+ + YRVL  +   + LK+AR D W   + C +   NST     F Y+    + V++FY C ++ +        P     F C         YY    +P     S+++  C+I + +PI +T    L  N     EA+  GF + +T  Y+ +C +C G  G CG
Sbjct:  272 DASYTNCSNAFSCGNNNFNLKYPFWGENRGNYCGGGPNLESEKLTCEAQVPKITINLIKYRVLGWENTSQILKVARDDYWDNNNICVNGDRNSTFDNSPFQYDYDGLVNVTLFYDCPASFSPSTIPSLPPSTVFSFPCGGG---SFVYYTAQALP-----SSYEAPCKI-VVIPIFQTNNDSL-ENSERIIEALQGGFEIEWTGNYE-KCEKCTGSGGECG 481          

Query:   97 SRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIY--VSIFYGCNS-TITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQC-LGVNGLCGFDSDSSEPVCICGNRVC 741
            +++  CG ++N+ +PF G  R   CG P   ++C  +   + I+   Y+VL+++P    L++ R D     C  K   +++  E + +   D  Y  +++FY  N    TT  L +     N +     Y    P+P     ++ K  +    P L  T     ++      AI +GF V +      +C +C +    +CG         C C +  C
Sbjct:   41 NQLISCGNIKNIGFPFWGEKRPRDCGHPRMQLSCEQEITYININDFRYKVLEVNPDNHTLRITREDYLEGICQPKFVTTSLDTELYVH---DSAYKNLTLFYCANDLPSTTGFLPSCVPNGNYV-----YPRFEPLPPPNYYASCKTVVVPVPPSLVDT-----SDADKIHNAIIDGFVVRWIVGI-GECEKCMISAGRVCGGIEWYPNQTCYCRDGPC 245          

Query:   91 NCSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKL---SNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFK-CEIGITVPILKTTAAKLV--ANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDS-DSSEPVCICGNRVCDP--------AGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTDKLVSSST 2004
            NCS+ F+CG + ++ YPF G +R  YCG PEF +NC   +  +TI  L+Y+VL+++   + LK+AR+D   + C     ++T+   +F+Y  SD   ++++YGC  +   P L   +N F CN+S  F  +  L        +M+ F+ C++ + VP  ++ A  L    N+     A+ +GF + +    ++ C  C    G CG +S D S   C C N   DP        +G+ +                  Q          ++K++PTP +SKS   P  N SQ+   PSY S  SKSD +KGSTYFG +VFSY EL EAT+NF+P+KELGDGGFGTVYYG L DGRVVAVKRL+ENN KR EQFMNE+EILTRL H+NLV LYGCTS+RSREL+LVYEYIPNGT+ADH+HG R +SG L+W VRLSIAIETADALA+LH +DVIHRDVKTNNIL+DN+F VKVADFGLSRLFPND THVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVL+ELISSLQAVDTNRHR DINLANMA+NKIQNH +NELVDP+L ++ ++ VR+M T+VAELAFRCLQQE+DMRPTM EVL+ L+ I++ED GSE  +A  LDI  DDV LL ++ P    +S  TDK VSSS+
Sbjct:   38 NCSQKFECGNITDIGYPFWGSNRPQYCGHPEFELNCTGQTAVITIEELTYQVLEINSEEKTLKVARTDYIDNICPSNPVSTTLNFNYFSYT-SDIQNITLYYGCPQSNPMPTLQDFTNQFSCNDSNGFFVTRNLSNLTAA--LMTYFRTCDVEVIVPANQSAAQSLENRPNQENLVIALEQGFGLEWRE--NSTCETCNISGGQCGSNSTDPSLFACYCTNGP-DPFSCGRSQSSGVGIAGAVVIGIGLGCWIFLYVQRKKRIAAQT-KNKDLPTPPSSKSQPAPVINFSQTT--PSYSS--SKSDLEKGSTYFGTKVFSYEELVEATDNFDPSKELGDGGFGTVYYGILSDGRVVAVKRLFENNMKRAEQFMNEIEILTRLRHKNLVTLYGCTSKRSRELVLVYEYIPNGTLADHIHGNRSKSGLLTWKVRLSIAIETADALAYLHASDVIHRDVKTNNILLDNNFRVKVADFGLSRLFPNDCTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLVELISSLQAVDTNRHRLDINLANMAVNKIQNHAINELVDPMLGYDKDYAVRKMTTSVAELAFRCLQQEKDMRPTMAEVLEALKKIESEDYGSEKTEA--LDIKEDDVVLLNHVAPFSPDESVTTDKWVSSSS 677          

Query:  106 FDCGPLRNLSYPF-TGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNW-----FHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRV----CDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSV------ATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDI--GADDVGLLRNMPPPLSPDSAGTDKLVSSSTPPSS 2016
            F CG + N+ YPF +   + +YCG P+F ++C  D+  + + S  + V+ +D   + LK+AR DLW   CT++  N  +  +FF Y  +DD Y ++ Y C   +T     N      F C     F+D+++ LG            C+  I V +L+      +   ++ ++    GF +N+T P    C  C    G CGFD +    +C C ++     C                                       ++P     K        +T  ++L+   + PS  S  + +D  K     GV +F Y ELEEAT  F+ +KELG+GGFGTVY+GKL+DGR VAVKRLYENNFKRV QFMNE++IL +L H NLVKLYGCTSR SRELLLVYEYIPNGTVADHLHG+R + G L W +R+ IA+ETA AL FLH  DVIHRDVKTNNIL+D+DFCVKVADFGLSRLFP+ VTHVSTAPQGTPGYVDPEY+QCYQLT +SDVYSFGVVL+ELISSL AVD  RHRH+INL+NMAINKI N  ++ELVDP L FE++  VR+M  AVAELAF+CLQ  ++MRP+M+EV++ L+ IQ++  G    Q  V+DI   ADDV LL++ PPP SPDS      VS ST P++
Sbjct:   40 FSCGEIDNIRYPFWSSDHQQSYCGHPKFKLDCQQDNVTIDMMSQRFHVIDIDQTSKVLKMARLDLWDDPCTNEYSNVKLDSDFFNYTSNDDDY-TLLYDCGPPVTYTSSVNIKGTISFSCPIDSGFRDAFFDLG------------CKHSINVSVLREAVKDALQVENVLEKGFEMGFVLNWTAP---DCHYCEKSGGRCGFDGNQF--LCFCKDKSYLKSCGSGNNTFWKYCDYTFVVCSAGTFLCNILTKVYQIVAFPFDLPLVKVHKYTCLCLLHSTTISSLNWHNANPSLLSLLTVADPRKLRLIIGVPLFLYDELEEATNYFDSSKELGEGGFGTVYFGKLRDGRSVAVKRLYENNFKRVAQFMNEIKILAKLVHPNLVKLYGCTSRHSRELLLVYEYIPNGTVADHLHGQRSKPGKLPWHIRMKIAVETASALNFLHHKDVIHRDVKTNNILLDSDFCVKVADFGLSRLFPDHVTHVSTAPQGTPGYVDPEYHQCYQLTKQSDVYSFGVVLVELISSLPAVDITRHRHEINLSNMAINKIHNQALHELVDPTLGFESDFKVRKMINAVAELAFQCLQSSKEMRPSMEEVVETLKDIQSD--GKHKSQPEVMDITSTADDVVLLKDDPPPPSPDS----NAVSKSTTPNA 670          

Query:  109 DCGPLRNLSYPF-TGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTS-TCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNS----TITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPI-MSTFKCEIGITVPILKTTAAKLVAN--RSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNR----VCDPAGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDIGADDVGLLRNMPPPLSPDSAGTD 1983
            +CG   N+SYPF     + +YCG P F I C ++ P LTIS   Y + ++     +  ++ S ++   +C   + N ++    F Y+ S    + +FY C S    T+T P       C ++     S+       L+ +  ST  C+  + VP+      +   N     F E + EGF +++T    N C+ C    G CGF+++  E +C C +R     C   GL                               + K  P PL S++++             S PS  SK+ ++   +  GV +F+Y ELEEAT NF+ +KELGDGGFGTVY+GKL+DGRVVAVKRLYENN+KRVEQFMNEVEIL  L HRNLV LYGCTSR SRELLLVYEY+PNGTVADHLHG++ + G L+WP R+ IAIETA AL +LH +D+IHRDVKTNNIL+D++F VKVADFGLSRLFP DVTHVSTAPQGTPGYVDP+Y+QCYQLT KSDVYSFGVVLIELISS+ AVD  RHRH+INL+NMAINKIQNH ++ELVD  L F+++  +RRM  AVAELAF+CLQ E++MRP MDEVL+ L  I++E  G    +   ++I AD VGLL++  PP SPDS  T+
Sbjct:  355 NCGTGPNVSYPFWIPKEQESYCGFPNFSITCNDEKPVLTISDDYYVIREIFYTNHSFLMSNSAVYDGDSCPTPLHNFSLDRTPFNYSPSH-YDLLLFYNCTSVPVETLTIP-----IDCMSNATLH-SFASFHEEALEYMNFSTESCQSMVNVPV-DIDGEEGFGNLLNWNFTEILREGFVLSWTA---NNCSSCERSGGRCGFENN--EFICFCQDRPHLRTCHDEGLNYHRKVIIGVCAGLGTLLISSIFFLMYLRRYK-KRYPPPLFSRNIS-------------SDPS--SKTIFESQGSLHGVHIFTYEELEEATNNFDSSKELGDGGFGTVYHGKLRDGRVVAVKRLYENNYKRVEQFMNEVEILQLLRHRNLVSLYGCTSRHSRELLLVYEYVPNGTVADHLHGEQAKPGSLTWPTRMKIAIETASALKYLHASDIIHRDVKTNNILLDSNFSVKVADFGLSRLFPTDVTHVSTAPQGTPGYVDPDYHQCYQLTSKSDVYSFGVVLIELISSMPAVDITRHRHEINLSNMAINKIQNHALHELVDRSLGFDSDQNIRRMIMAVAELAFQCLQNEKEMRPAMDEVLEVLMGIESE--GCNIVKTEEVEIPADSVGLLKSKQPPASPDSVTTN 961          

Query:   76 NANLSNC-SRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDS-PELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTI-----TTPKLSNWFHC-----NNSLAFQDSYYLLGPVPLDPIMSTFK-CEIGITVPILKTTAAKLVANRS--------LFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNR 735
            N     C S +++CG ++ + YPF G  R  +CG   F + C ND  P + I SL +RVL +      +++AR D W  TC  +  ++T+    F Y    D  +++FYGC   +      T  +SN F C     N++ AF      LG   LD  ++  + C+I +T+P+L     +L ANR+          ++A+N GF V+Y +     C  C    G+CG  S SS   C+C ++
Sbjct:   33 NQQYEECTSSLYECGDMKGIGYPFWGDGRPKFCGQQGFELKCQNDDYPLIDIGSLEFRVLNISNSTYAMRIARKDFWDQTCPKEFQSTTLNYTLFDY-AGTDRNLTLFYGCPDDVLSQLPATWNISNNFTCSVEDINDTTAFYADEAFLG---LDQHLAILRTCKINVTLPVLGAAIDELNANRTGGEFSNGERLEKAMNMGFDVDY-SVVRGLCVHCNTTGGICGSSSTSSFS-CLCRDK 267          

Query:   91 NCSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFY-GCNSTITT------PKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEIGITVPILKTTAAKLVANRSL--FQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVCICGNRVCDP-----------AGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIPTPLTSKSVATPSTNLSQSQSIPSYPSFT-----------SKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNEDLGSEDGQAVVLDI-GADDVGLLRN-MPPPLSPDSAGTDKLV--SSSTPPSSF 2019
            +CS  F CG    L YPF    R   CG P+F +NC  D  ELT+S++ +++L+++     ++LAR D   + C     N+++  +   +  S D  +S FY  C ST+         +L+   +      F  S    G       +S   CE G+ +P+ ++    +  N+SL   ++AI+EGF + +    +N+C+QC    G CGFD      VC C +   +            AGL+                              + K++ T  T+K ++T +T  S + ++ + P+ T           S S+   GS Y G+QVFSY ELEEATENF+  KELGDGGFGTVYYG L+DGR VAVKRL+E + KRVEQF NE++IL  L+H NLV LYGCT+R SRELLLVYEYI NGT+A+HLHG + +S  + WP RL IAIETA AL++LH + +IHRDVKT NIL+D+++ VKVADFGLSRLFP D TH+STAPQGTPGYVDPEYYQCY+L +KSDVYSFGVVL ELISS +AVD  RHRHDINLANMAI+KIQN  V+EL D  L F  +  V++M ++VAELAFRCLQQERD+RP+MDE+++ LR IQ + +       V +D+ G DDVGLL++ +PPPLSP+   TDK    SS+T  SSF
Sbjct:  317 HCSPRFKCGNQSELYYPFWISERKE-CGHPDFEVNCSGDFAELTVSTVKFQILEMNYEFEIIRLARMDYRNNLCPQHPANASINHDVLPF--SPDTKLSTFYHDCQSTVDVHPNDYIKQLNCEDYIGGKSYFVSSSSHSGDRATLAALSA-SCE-GVDIPVSRSALKTVEKNQSLEAMKKAIDEGFELGF----NNECSQCAISGGACGFDQRLKAFVCYCADEPHESTCYSEIVKKTHAGLSKKGKIGIGFASGFLGATLI-GGCLLCIFIRRRKKLATQYTNKGLST-TTPYSSNYTMSNTPTSTTISGSNHSLVPSISNLGNGSVYSGIQVFSYEELEEATENFS--KELGDGGFGTVYYGTLKDGRAVAVKRLFERSLKRVEQFKNEIDILKSLKHPNLVILYGCTTRHSRELLLVYEYISNGTLAEHLHGNQAQSRPICWPARLQIAIETASALSYLHASGIIHRDVKTTNILLDSNYQVKVADFGLSRLFPMDQTHISTAPQGTPGYVDPEYYQCYRLNEKSDVYSFGVVLSELISSKEAVDITRHRHDINLANMAISKIQNDAVHELADLSLGFARDPSVKKMMSSVAELAFRCLQQERDVRPSMDEIVEVLRVIQKDGISDSKDVVVEIDVNGGDDVGLLKHGVPPPLSPE---TDKTTASSSNTTASSF 978          

Query:   94 CSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINCVN--DSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSIFYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLDPIMSTFKCEI-GITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSSEPVC 720
            C  +F CG L    +PF G +R   CG P   ++C    +S  L ISSL YRVL+++     LKL R D     C+     +T+ PE F     D   +S +Y CN ++  P     F C N          +G +  D +       I  ITVPI      +   N +  +  + +GF V  +   +  C +C    G+C +    + PVC
Sbjct:   38 CDTLFRCGDL-TAGFPFWGVARPQPCGHPSLGLHCQKQTNSTSLIISSLMYRVLEVNTTTSTLKLVRQDFSGPFCSASFSGATLTPELFEL-LPDYKTLSAYYLCNPSLHYPAK---FICPNK--------GVGSIHQDDLYHNHCGGIFNITVPI-GYAPEEGALNVTNLESVLKKGFEVKLSID-ERPCQECKTNGGICAY--HVATPVC 232          

Query:   88 SNCSRVFDCGPLRNLSYPFTGGSRSAYCGPPEFHINC-VNDSPELTISSLSYRVLQLDPVRRNLKLARSDLWTSTCTDKVFNSTMKPEFFAYNESDDIYVSI-FYGCNSTITTPKLSNWFHCNNSLAFQDSYYLLGPVPLD---PIMSTFKCEIGITVPILKTTAAKLVANRSLFQEAINEGFTVNYTNPYDNQCAQCLGVNGLCGFDSDSS-EPVCICGNRVCDP-------AGLAVXXXXXXXXXXXXXXXXXXQXXXXXXXXXXQSKEIP-TPLTSKSVAT--PSTNLSQSQSIPSYPSFTSKSDYDKGSTYFGVQVFSYTELEEATENFNPAKELGDGGFGTVYYGKLQDGRVVAVKRLYENNFKRVEQFMNEVEILTRLEHRNLVKLYGCTSRRSRELLLVYEYIPNGTVADHLHGKRVESGFLSWPVRLSIAIETADALAFLHRNDVIHRDVKTNNILIDNDFCVKVADFGLSRLFPNDVTHVSTAPQGTPGYVDPEYYQCYQLTDKSDVYSFGVVLIELISSLQAVDTNRHRHDINLANMAINKIQNHLVNELVDPLLEFETNHVVRRMATAVAELAFRCLQQERDMRPTMDEVLDGLRAIQNED-----LGSEDGQAVVLDI---GADDVGLLRN-MPPPLSPDSAGTDKLVSSSTPPSS 2016
            S C  +F CG +   S+PF GG R  +CG P   + C  N S  L IS   + VL +D    +L LAR DL  S C+ K  N+T+ PE F   E    Y S+ FY C   +  P LSN+           +  ++GP+ +        T        VP    T  K + N +  +  + +GF VN  N     C +C   N  CGFD +   E  C   +   D        AG+AV                  +           SK +P T  +S+  +    ST +S S +    PS ++ ++   GS Y GVQVFSY ELEEATENF+  +ELGDGGFGTVYYG L+DGR VAVKRLYE + KRVEQF NE+EIL  L+H NLV LYGCTSR SRELLLVYEYI NGT+A+HLHG R E+  L W  RL+IAIETA AL+FLH   +IHRD+KT NIL+D+++ VKVADFGLSRLFP D TH+STAPQGTPGYVDPEYYQCYQL +KSDVYSFGVVL ELISS +AVD  RHRHDINLANMA++KIQN+ ++ELVD  L F+ +  VRR   AV+ELAFRCLQQERD+RP MDE+++ LR I++++     + S D    V+DI   G DDVGLLRN +PPP+SP+   TDK  SSS   +S
Sbjct:   26 SKCESLFQCGNI-TASFPFWGGDRHKHCGHPLLELRCDQNKSTSLFISDQEFYVLHVDQTSYSLTLARPDLLDSFCSLKFTNTTLPPEIF---ELSPAYKSVTFYHCYPVL--PDLSNY-----------TCPVIGPISVSGNPEDHETCFANFAANVPKSFVTKEKKL-NITNLESVLEKGFEVNM-NVIMKACQECSYSNESCGFDENFPFEVKCKPHHSPTDTGLSPGAKAGIAVASVSGLAILILAGLFLYIRRRRKTQDAQYTSKSLPITSYSSRDTSRNPTSTTISSSSNHSLLPSISNLAN---GSDYCGVQVFSYEELEEATENFS--RELGDGGFGTVYYGVLKDGRAVAVKRLYERSLKRVEQFKNEIEILKSLKHPNLVILYGCTSRHSRELLLVYEYISNGTLAEHLHGNRAEARPLCWSTRLNIAIETASALSFLHIKGIIHRDIKTTNILLDDNYQVKVADFGLSRLFPMDQTHISTAPQGTPGYVDPEYYQCYQLNEKSDVYSFGVVLTELISSKEAVDITRHRHDINLANMAVSKIQNNALHELVDSSLGFDNDPEVRRKMMAVSELAFRCLQQERDVRPAMDEIVEILRGIKDDEKKRVLVKSPD----VVDIECGGGDDVGLLRNSVPPPISPE---TDKWTSSSDTAAS 662